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Mandibular prognathia AND surgery (LeFortI or BSSO), including avohilmo

Endpoint Browser

K11_MN_PROGN_AND_SURGRT_INCLAVO

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 — K07.11

1 out of 7 registries used, show all original rules.

267

4. Check minimum number of events

None

267

5. Include endpoints

452

6. Filter based on genotype QC (FinnGen only)

387

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF6

Case counts by codes

↥

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8708 3947 4747
Only index persons 7257 3299 3958
Unadjusted period prevalence (%)
Whole population 0.12 0.11 0.13
Only index persons 0.14 0.12 0.15
Median age at first event (years)
Whole population 12.20 12.16 12.17
Only index persons 13.34 13.35 13.33

-FinnGen-

Key figures

All Female Male
Number of individuals 387 232 155
Unadjusted period prevalence (%) 0.08 0.08 0.07
Median age at first event (years) 27.99 28.60 27.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
423
Matched controls
4230
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K07.11
ICD-10 Finland
Retrognathism (mandibular)(maxillary)
+∞
307.7
423
*
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
26.6
243.6
204
143
SJD00
NOMESCO Finland
Removal and/or reactivation of orthodontic arch wire
15.5
173.7
200
232
SBB10
NOMESCO Finland
Dental impressions
14.0
171.2
281
524
EEC05
NOMESCO Finland
Le Fort I osteotomy
1198.6
169.1
154
*
K07.14
ICD-10 Finland
Retrognaty, maxillary
316.8
166.4
159
8
EB1MA
NOMESCO Finland
Cephalometry with X-ray
15.2
165.2
187
210
SJD20
NOMESCO Finland
Placement of modified orthodontic arch wire
15.4
151.8
161
162
SJD10
NOMESCO Finland
Placement of orthodontic arch wire
13.3
150.8
188
240
SJC50
NOMESCO Finland
Removal of fixed orthodontic appliance with at least 7 brackets
13.7
145.0
170
198
SJD30
NOMESCO Finland
Demanding placement of orthodontic arch wire
18.7
142.0
127
95
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
13.5
138.2
160
182
SJC10
NOMESCO Finland
Orthodontic band in one tooth
12.8
136.2
166
203
SJD40
NOMESCO Finland
Placement of prefabricated palatal or lingual arch
10.6
119.2
170
252
SJB00
NOMESCO Finland
Fitting of removable appliance incl. patient instructions
9.8
106.5
158
243
EDC10
NOMESCO Finland
Sagittal osteotomy of ramus of mandible
231.8
105.8
105
6
SJX10
NOMESCO Finland
Orthodontic treatment/control appointment, short
8.5
100.3
177
330
K07.24
ICD-10 Finland
Open bite
19.7
94.9
78
48
SAA04
NOMESCO Finland
Special examination of mouth
8.2
86.9
147
258
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
12.4
84.8
93
94
SJC03
NOMESCO Finland
Positioning and fixed attachment of brackets, extensive
9.3
81.5
116
166
K07.13
ICD-10 Finland
Retrognaty, mandibular
15.5
79.7
74
57
SXC05
NOMESCO Finland
Other oral or dental procedure
5.7
64.1
168
439
K07.10
ICD-10 Finland
Asymmetry of jaw
129.9
62.9
66
6
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
7.1
61.6
111
203
SJC40
NOMESCO Finland
Removal of fixed orthodontic appliance with at most 6 brackets
5.7
50.5
114
256
SJC02
NOMESCO Finland
Positioning and fixed attachment of brackets
7.4
49.0
79
127
SJX20
NOMESCO Finland
Orthodontic treatment/control appointment
6.1
47.7
96
193
SJX21
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment
5.7
47.4
105
231
SAA03
NOMESCO Finland
Extended examination of mouth
4.9
45.1
329
1760
K07.1
ICD-10 Finland
Anomalies of jaw-cranial base relationship
244.8
43.8
44
*
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
4.6
41.5
123
343
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
4.1
41.3
297
1533
SJB60
NOMESCO Finland
Adjustment and grinding of removable appliance
5.8
40.1
83
170
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
5.8
39.3
81
165
SJC00
NOMESCO Finland
Bondable bracket or other fixed attachement
88.2
36.5
40
5
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
5.2
36.2
85
194
WZC00
NOMESCO Finland
Treatment plan or consultation
3.6
35.7
261
1317
SAC03
NOMESCO Finland
Separate planning of oral and dental treatment, very demanding
13.7
34.4
33
26
SJX11
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment, restricted
4.2
33.2
110
329
K07.18
ICD-10 Finland
Another anomaly in the relationship between jaw and skull base
178.5
32.2
33
*
K07.01
ICD-10 Finland
Hyperplasia, hypoplasia mandibular
92.3
31.2
34
*
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
4.5
31.1
88
233
K07.60
ICD-10 Finland
Snapping jaw
5.3
30.9
69
150
EFB40
NOMESCO Finland
Removal of internal or external fixation device from facial bones
61.4
29.6
34
6
SJA04
NOMESCO Finland
Very demanding workplan for orthodontic treatment
111.2
29.1
31
*
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
6.5
28.1
49
84
K07.21
ICD-10 Finland
Anomalies of dental arch relationship
30.1
27.2
36
13
SJA03
NOMESCO Finland
Demanding workplan for orthodontic treatment
53.6
25.6
30
6
K07.03
ICD-10 Finland
Micrognatia (hypoplasia) of the upper jaw
71.8
24.1
27
*
K07.19
ICD-10 Finland
Anomalies in the relationship between jaw and skull base UNS
220.4
20.8
21
*
SJX00
NOMESCO Finland
Reparation of orthodontic appliance by dentist
8.3
20.6
28
36
K07.30
ICD-10 Finland
Spacing, abnormal of tooth or teeth
3.4
19.6
80
269
EBB10
NOMESCO Finland
Insertion of dental implant
19.3
19.4
29
16
K07.12
ICD-10 Finland
Prognathism (mandibular)(maxillary)
57.8
19.1
22
*
SJD50
NOMESCO Finland
Placement of prefabricated palatal or lingual arch, dentist-made
7.0
18.5
29
44
SAC02
NOMESCO Finland
Separate planning of oral and dental treatment, demanding
4.3
18.2
51
132
SJA01
NOMESCO Finland
Assesment of orthodontic treatment need
38.6
17.8
22
6
K07.69
ICD-10 Finland
Dislocation of the jaw joint UNS
7.8
17.6
25
34
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
7.2
17.2
26
38
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
7.1
15.0
23
34
ZXE20
NOMESCO Finland
More than three and less than five hours
3.0
14.6
75
287
SXC03
NOMESCO Finland
Other oral or dental procedure
23.2
14.3
20
9
K00.00
ICD-10 Finland
Hypodontia
4.8
13.5
31
68
SAC01
NOMESCO Finland
Separate planning of oral and dental treatment, standard
3.5
13.5
50
157
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
10.6
13.2
25
25
K07.4
ICD-10 Finland
Malocclusion, unspecified
5.3
13.1
27
54
SJA02
NOMESCO Finland
Workplan for orthodontic treatment
33.2
12.7
16
5
SDA03
NOMESCO Finland
Periodontal treatment
2.1
12.0
205
1321
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
12.2
11.9
21
18
SAA02
NOMESCO Finland
Basic examination of mouth
2.8
11.9
370
3013
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.9
11.8
36
99
EB1WA, ,
NOMESCO Finland
17.0
11.8
18
11
SPA02
NOMESCO Finland
Preparation for dental prosthetics
5.2
11.6
24
48
SJB30
NOMESCO Finland
Extraoral traction arrangements and operation instruction, removable appliance
4.4
11.5
29
69
SJB10
NOMESCO Finland
Fitting of removable appliance incl. patient instructions, demanding
3.7
11.3
37
107
OIKK, ,
NOMESCO Finland
2.8
11.1
62
247
SJF01
NOMESCO Finland
Assessment of need for orthodontic treatment
2.8
11.0
58
224
SXB00
NOMESCO Finland
Removal of sutures from oral mucosa
3.3
10.8
42
136
WZA90
NOMESCO Finland
Other medical or dental certificate
2.0
10.0
146
877
QA1S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in head
12.6
9.9
17
14
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
9.6
124
710
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
4.4
9.0
23
55
K01.0
ICD-10 Finland
Embedded teeth
3.9
8.9
26
69
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
6.8
8.8
21
32
EBB15
NOMESCO Finland
Insertion of dental implant abutment
14.4
8.7
14
10
Z3229
NOMESCO Finland
Other healthcare associate professional
2.6
8.7
52
214
SPC20
NOMESCO Finland
Implant borne crown
20.5
8.5
12
6
SHA04
NOMESCO Finland
Stomatognathic treatment, very demanding
8.0
7.9
17
22
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
13.4
7.9
13
10
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
1.9
7.8
111
653
SAA01
NOMESCO Finland
Simple examination of mouth
2.1
7.8
351
2953
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.2
7.8
31
102
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.9
7.7
23
62
SPB10
NOMESCO Finland
Manufacture of a temporary crown to tooth at the dental office
18.8
7.6
11
6
SJE90
NOMESCO Finland
Orthodontic finishing
9.1
7.6
15
17
SPC10
NOMESCO Finland
Standard dental crown
10.3
7.6
14
14
EBA10
NOMESCO Finland
Operative extraction of tooth
2.0
7.5
102
591
SPA48
NOMESCO Finland
Precision impression for denture, demanding
81.5
7.4
8
*
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
2.2
7.2
64
316
SDA02
NOMESCO Finland
Periodontal treatment, brief
1.7
7.1
185
1303
Z97.2
ICD-10 Finland
Presence of dental prosthetic device (complete)(partial)
7.2
7.1
16
23
G50.1
ICD-10 Finland
Atypical facial pain
7.7
7.0
15
20
F45.8
ICD-10 Finland
Other somatoform disorders
2.5
6.9
46
199
WX720
NOMESCO Finland
Own respiration
3.3
6.8
26
83
ZXA10
NOMESCO Finland
Bilateral
2.0
6.7
79
434
OIKRE, ,
NOMESCO Finland
6.4
6.5
16
26
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.0
6.5
77
423
EBA00
NOMESCO Finland
Extraction of tooth
1.7
6.5
196
1429
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
5.3
6.4
18
35
SPF00
NOMESCO Finland
Reparation of dental prosthesis without impressions
8.3
6.4
13
16
SPA51
NOMESCO Finland
Determination of bite and dental arch location, demanding
11.3
6.3
11
10
OIKKK, ,
NOMESCO Finland
9.5
6.3
12
13
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
18.3
6.3
9
5
K07.29
ICD-10 Finland
Anomaly in the relationship between the tooth arches UNS
+∞
6.3
6
*
Z01.2
ICD-10 Finland
Dental examination
1.7
6.1
251
1973
J01CE02
ATC
phenoxymethylpenicillin; oral
1.7
6.1
285
2317

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
120
889
1.49
3.23
3.4
3.1
1.02
1.02
kg/l
0.34
73
555
222
1851
1.42
3.16
3.3
3.6
0.00
0.00
estimate
-0.00
38
365
218
1841
1.38
2.73
3.4
3.6
41.83
0.00
estimate
0.49
40
383
355
3274
1.52
2.61
14.7
16.0
13.22
13.26
%
0.29
349
3243
72
508
1.50
2.43
1.8
1.6
437.47
40889338.65
pmol/l
0.76
63
450
131
1041
1.37
2.31
3.2
3.0
0.00
0.00
estimate
0.50
30
318
219
1891
1.33
2.20
3.6
6.0
6.41
6.39
mmol/l
0.06
202
1736
19
95
2.05
2.14
3.1
9.7
0.88
0.86
%
0.11
19
87
367
3445
1.49
2.09
11.5
13.8
3.95
3.92
mmol/l
0.70
360
3362
11
44
2.54
2.02
2.0
1.7
13.00
13.28
%
0.47
11
44
210
1822
1.30
1.96
3.3
3.6
0.00
0.00
estimate
-0.00
38
384
366
3443
1.47
1.96
11.5
13.8
139.65
139.68
mmol/l
0.10
361
3373
39
253
1.60
1.92
2.0
1.9
14.91
15.24
iu/l
0.03
34
191
182
1553
1.30
1.91
4.8
9.2
1.23
1.22
mmol/l
1.99
164
1396
162
1366
1.30
1.85
3.2
3.3
0.00
0.01
estimate
0.80
31
327
262
2356
1.29
1.80
4.1
4.3
—
1.59
—
0
6
310
2856
1.32
1.75
4.9
4.2
14.39
14.52
pmol/l
0.49
290
2639
9
36
2.53
1.75
1.0
1.0
—
—
—
0
0
315
2909
1.32
1.75
5.7
4.9
37.53
37.61
mmol/mol
0.06
303
2780
177
1519
1.28
1.74
3.6
3.2
6.16
6.24
ph
0.42
94
821
19
105
1.85
1.66
3.2
9.0
1.55
1.57
%
0.06
19
96
7
26
2.72
1.58
1.6
1.7
0.49
0.47
e9/l
—
7
26
50
359
1.45
1.58
1.3
1.6
1204.80
1135.19
nmol/l
0.24
41
285
54
395
1.42
1.55
1.3
1.6
—
—
—
0
0
37
251
1.52
1.54
2.2
1.9
6.20
6.18
ph
0.04
22
158
7
28
2.52
1.45
1.1
1.2
241.86
186.83
pmol/l
—
7
28
24
149
1.65
1.44
1.7
1.8
35.83
38.67
nmol/l
0.36
24
144
7
29
2.44
1.39
6.4
5.9
0.71
1.63
ug/l
—
7
29
161
1396
1.25
1.39
3.0
2.6
—
—
—
0
0
5
18
2.80
1.29
1.0
1.1
—
—
—
0
0
28
188
1.52
1.25
1.1
1.2
2.00
3.34
u/ml
0.31
17
126
346
3291
1.28
1.18
5.7
5.0
1.83
1.83
mu/l
0.04
325
3110
25
166
1.54
1.18
1.0
1.2
3.45
0.89
u/ml
0.38
16
103
25
166
1.54
1.18
1.1
1.1
3.69
1.88
u/ml
0.26
15
109
13
221
0.58
1.16
1.5
1.4
—
—
—
0
0
0
35
0.00
1.15
0.0
35.2
—
6.53
—
0
30
51
392
1.34
1.12
1.9
1.9
—
—
—
0
0
25
169
1.51
1.10
1.1
1.2
14.61
7.63
u/ml
0.70
17
121
13
74
1.78
1.08
1.3
1.1
—
—
—
0
0
335
3191
1.24
1.01
4.8
4.6
2.69
2.77
mmol/l
0.83
322
3027
17
107
1.61
1.01
1.0
1.1
—
—
—
0
0
17
107
1.61
1.01
1.0
1.1
—
—
—
0
0
334
3182
1.24
1.00
4.4
4.2
4.56
4.63
mmol/l
0.65
320
3034
49
382
1.32
0.99
1.4
1.3
—
—
—
0
0
375
3623
1.31
0.98
11.3
12.4
20.81
21.53
mg/l
0.18
297
2790
0
30
0.00
0.97
0.0
1.0
—
29.44
—
0
23
29
208
1.42
0.97
1.0
1.2
—
—
—
0
0
9
51
1.78
0.95
2.6
14.6
105.78
104.95
mmol/l
—
9
44
9
51
1.78
0.95
2.6
14.6
11.22
11.02
mmol/l
—
9
44
17
109
1.58
0.95
1.2
1.1
10.31
12.19
u/ml
0.11
11
57
180
1970
0.85
0.90
6.0
7.5
0.04
0.04
e9/l
0.03
158
1671
331
3165
1.21
0.87
4.2
4.1
1.44
1.44
mmol/l
0.01
317
3000
11
64
1.74
0.87
2.1
5.5
9.69
6.77
pmol/l
0.46
11
64
22
155
1.44
0.83
1.0
1.2
—
—
—
0
0
13
81
1.62
0.82
4.2
3.8
7.42
7.40
ph
0.39
13
81
9
150
0.59
0.80
2.0
1.7
0.19
0.23
g/l
—
9
143
9
151
0.59
0.80
2.0
1.7
1.09
1.20
g/l
—
9
142
73
617
1.22
0.79
1.2
1.3
10.48
7.45
u/ml
0.13
30
238
24
174
1.40
0.78
1.5
1.2
—
—
—
0
0
10
162
0.61
0.78
2.1
6.0
0.84
1.44
%
—
10
162
171
1560
1.16
0.78
2.6
3.0
—
—
estimate
—
0
0
91
788
1.20
0.78
1.5
1.5
19.45
19.94
nmol/l
0.14
82
689
6
34
1.78
0.76
2.5
1.8
92.67
91.33
%
—
6
34
131
1174
1.17
0.75
6.7
8.3
1.11
1.13
inr
0.15
109
975
182
1969
0.87
0.74
5.9
7.5
0.52
0.54
e9/l
1.37
161
1674
61
511
1.23
0.73
2.0
3.0
14.14
14.49
umol/l
0.16
56
478
11
68
1.63
0.72
1.1
1.1
—
—
—
0
0
58
484
1.23
0.72
1.1
1.2
—
—
—
0
0
9
59
1.54
0.68
1.3
1.2
—
—
—
0
0
10
156
0.63
0.68
2.1
6.1
0.72
0.59
%
—
10
156
7
119
0.58
0.68
1.0
1.1
—
—
—
0
0
5
27
1.86
0.68
3.0
2.3
4.08
3.94
mmol/l
—
5
27
5
27
1.86
0.68
3.0
2.3
1.19
1.19
mmol/l
—
5
27
5
27
1.86
0.68
3.0
2.3
104.00
106.30
mmol/l
—
5
27
150
1367
1.15
0.68
2.1
1.9
1.36
1.36
mmol/l
0.02
133
1221
41
331
1.26
0.68
2.1
3.2
9.83
9.87
g/l
0.02
36
311
30
382
0.77
0.67
6.5
13.1
24.49
24.84
mmol/l
0.44
30
382
318
3055
1.16
0.67
4.4
3.8
5.69
5.69
mmol/l
0.02
301
2840
20
270
0.73
0.67
5.9
6.4
23.48
24.37
mmol/l
1.07
20
265
8
130
0.61
0.64
1.0
1.9
—
—
—
0
0
107
956
1.16
0.64
3.0
2.9
48.29
26.70
ng/l
0.33
54
531
45
541
0.81
0.63
1.6
1.5
648.89
505.28
titre
—
9
106
12
79
1.53
0.63
1.1
1.7
22.87
19.48
ng/l
0.52
12
79
17
233
0.72
0.63
1.8
2.0
—
—
—
0
0
13
187
0.69
0.62
1.7
2.7
67.49
66.90
g/l
0.10
13
176
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
2.4
—
—
—
0
0
139
1271
1.14
0.60
1.7
1.6
1.00
2.71
u/ml
1.79
31
302
0
22
0.00
0.59
0.0
1.0
—
204.11
—
0
22
64
552
1.19
0.59
3.1
3.4
66.04
744.24
ng/l
2.41
45
343
45
375
1.22
0.58
1.5
1.4
—
—
—
0
0
19
141
1.36
0.57
2.4
10.4
24.73
24.66
mmol/l
0.05
19
131
153
1414
1.13
0.56
4.2
9.1
1.23
1.22
mmol/l
1.09
144
1331
191
2032
0.89
0.55
5.9
8.0
0.20
0.19
e9/l
0.34
173
1766
53
456
1.19
0.51
1.9
3.0
2.60
2.44
g/l
1.30
47
422
33
398
0.81
0.50
4.1
13.3
—
—
—
0
0
38
318
1.21
0.49
1.2
1.6
—
—
—
0
0
96
869
1.14
0.48
3.1
4.1
7.40
7.39
ph
0.22
67
619
123
1131
1.12
0.48
4.1
7.1
—
—
—
0
0
191
2020
0.90
0.48
5.8
7.5
1.99
2.07
e9/l
0.50
173
1767
21
164
1.30
0.47
3.4
15.7
17.36
16.09
%
1.15
21
155
12
85
1.42
0.47
4.1
3.0
51.43
17.71
mu/l
0.46
12
80
8
117
0.68
0.46
1.0
1.4
—
—
—
0
0
168
1785
0.90
0.46
11.7
10.7
0.00
0.00
e9/l
0.65
136
1404
27
329
0.81
0.45
2.3
2.4
21511.41
6229.82
u/l
—
8
123
23
285
0.80
0.45
2.2
1.9
0.00
0.04
estimate
—
6
75
119
1284
0.90
0.43
4.2
4.4
29.22
60.28
e6/l
1.11
80
843
6
91
0.65
0.43
1.0
1.2
—
—
—
0
0
204
1940
1.10
0.42
3.5
3.3
67.33
80.90
ug/l
1.29
195
1848
8
57
1.41
0.42
8.0
3.4
—
—
—
0
0
38
324
1.19
0.42
2.6
2.5
28.67
182.87
u/l
0.51
33
269
5
33
1.52
0.41
3.2
1.8
—
—
—
0
0
5
33
1.52
0.41
9.6
9.2
0.54
0.57
mmol/l
—
5
33
0
15
0.00
0.41
0.0
1.0
—
2.80
—
0
5
0
15
0.00
0.41
0.0
1.1
—
242.90
—
0
10
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
5.7
—
226.33
—
0
6
0
16
0.00
0.41
0.0
3.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.0
—
16.03
—
0
7
0
17
0.00
0.40
0.0
3.4
—
—
—
0
0
17
215
0.78
0.40
3.3
4.2
2.34
28.33
ug/l
0.68
12
169
13
97
1.35
0.40
1.4
1.4
245.29
325.45
ug/g
—
7
52
130
1213
1.10
0.39
1.9
1.8
103.07
97.82
pmol/l
0.57
76
620
0
19
0.00
0.39
0.0
1.0
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
135
1263
1.10
0.39
4.6
6.3
37.65
37.61
g/l
0.03
125
1208
38
439
0.85
0.38
3.4
8.6
7.39
7.37
ph
1.91
25
279
5
36
1.39
0.38
1.6
1.4
—
—
nmol/l
—
0
0
28
332
0.83
0.38
2.5
2.7
0.49
0.69
ug/l
2.07
11
173
84
917
0.90
0.38
3.6
2.5
—
—
—
0
0
381
3750
1.16
0.37
11.4
10.1
—
—
—
0
0
9
69
1.31
0.37
1.1
1.1
—
—
—
0
0
170
1611
1.09
0.37
4.5
7.1
12.68
11.42
umol/l
0.40
163
1522
100
1080
0.90
0.37
3.7
3.7
32.87
95.41
e6/l
0.49
78
802
5
37
1.36
0.37
1.0
1.0
—
—
—
0
0
9
70
1.29
0.37
1.7
2.0
—
—
—
0
0
19
234
0.80
0.37
1.6
1.6
0.11
0.25
mg/l
—
6
97
42
367
1.16
0.36
1.3
1.2
—
—
—
0
0
5
78
0.64
0.36
1.2
1.1
—
—
—
0
0
31
264
1.19
0.36
4.2
5.8
0.00
0.07
%
—
8
72
6
42
1.43
0.35
1.3
1.6
—
—
—
0
0
33
283
1.18
0.35
4.0
3.9
—
—
—
0
0
50
561
0.88
0.35
4.2
3.4
2.84
3.08
e6/l
0.11
25
275
6
43
1.40
0.35
1.2
1.3
8.35
11.45
u/l
—
6
38
114
1064
1.10
0.34
2.0
2.6
—
—
—
0
0
19
154
1.24
0.34
1.5
1.6
2.78
7.81
u/ml
—
5
38
40
350
1.16
0.34
1.6
1.4
—
—
—
0
0
14
109
1.29
0.34
1.0
1.1
1.14
1.79
u/ml
—
5
48
47
418
1.14
0.33
2.0
3.2
22.43
23.90
%
0.35
42
397
88
949
0.91
0.32
3.8
3.7
0.40
0.33
e6/l
0.10
66
675
39
343
1.15
0.32
4.9
1.9
—
—
—
0
0
120
1128
1.09
0.31
4.1
3.8
8.38
8.64
mmol/l
0.22
110
1007
42
372
1.14
0.31
1.4
1.6
3.06
3.40
mmol/l
1.01
26
265
16
129
1.25
0.30
1.3
1.1
2.56
6.95
u/ml
—
9
78
82
885
0.91
0.30
4.6
5.0
—
—
—
0
0
13
102
1.28
0.30
1.3
2.9
4.38
9.53
e6/l
—
8
76
17
205
0.82
0.28
1.0
1.1
—
—
—
0
0
9
120
0.74
0.27
1.1
1.5
—
84.00
—
0
15
28
243
1.16
0.27
2.6
13.7
126.29
123.21
g/l
0.36
28
236
406
4026
1.21
0.27
18.0
18.9
259.76
260.38
e9/l
0.07
399
3948
79
735
1.09
0.26
1.6
2.5
0.74
1.14
mg/l
1.22
59
546
32
282
1.15
0.26
4.2
5.6
0.22
0.91
%
—
9
91
153
1598
0.93
0.26
2.9
3.0
71.10
71.07
nmol/l
0.01
148
1501
19
160
1.20
0.26
2.9
6.6
197.30
347.04
mg/l
—
10
102
88
937
0.92
0.25
1.9
1.8
—
—
—
0
0
25
286
0.87
0.24
5.2
6.9
—
—
—
0
0
34
380
0.89
0.24
3.1
10.1
104.97
104.94
mmol/l
0.01
34
380
374
3695
1.11
0.24
9.0
10.3
26.88
26.76
u/l
0.03
365
3608
108
1024
1.07
0.23
2.3
3.1
2.38
2.37
mmol/l
0.37
101
950
303
2971
1.07
0.23
3.6
3.6
1.26
1.23
mmol/l
0.22
286
2804
68
633
1.09
0.23
3.2
3.0
563.28
560.83
mosm/kgh2o
0.03
60
558
67
624
1.09
0.22
1.6
1.7
—
—
—
0
0
40
440
0.90
0.22
1.7
2.1
—
—
—
0
0
177
1831
0.94
0.22
6.2
7.7
3.18
2.95
%
0.63
170
1737
406
4031
1.18
0.22
18.1
18.9
6.64
6.66
e9/l
0.07
396
3939
406
4031
1.18
0.22
18.0
18.8
4.65
4.60
e12/l
1.58
397
3943
96
909
1.07
0.22
2.5
2.5
2.31
2.59
mg/l
0.59
90
801
0
11
0.00
0.21
0.0
1.2
—
11.99
—
0
11
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
2.1
—
0.60
—
0
13
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
2.8
—
28.00
—
0
13
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
125
1197
1.06
0.20
2.0
1.9
—
—
—
0
0
6
48
1.25
0.20
1.2
3.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
6.4
—
17.42
—
0
14
9
112
0.80
0.20
1.0
1.2
—
—
—
0
0
117
1120
1.06
0.19
1.7
1.6
1.81
1.97
g/l
0.52
74
666
101
963
1.06
0.19
3.0
3.5
0.00
0.00
estimate
0.50
37
367
46
425
1.09
0.19
4.4
1.9
—
—
—
0
0
46
425
1.09
0.19
4.4
1.8
—
—
—
0
0
15
128
1.18
0.18
1.7
1.4
—
—
—
0
0
15
128
1.18
0.18
2.1
8.3
—
—
—
0
0
7
58
1.21
0.18
5.4
4.0
9.23
8.89
kpa
—
7
58
7
58
1.21
0.18
5.4
4.0
4.73
4.96
kpa
—
7
58
17
195
0.87
0.18
1.1
1.1
—
—
—
0
0
11
91
1.21
0.17
1.4
3.2
—
—
—
0
0
81
769
1.07
0.17
2.3
1.9
—
—
—
0
0
5
69
0.72
0.17
1.2
1.8
—
—
—
0
0
5
69
0.72
0.17
1.2
1.8
—
—
—
0
0
5
69
0.72
0.17
1.2
1.8
—
—
—
0
0
5
69
0.72
0.17
1.2
1.8
—
—
—
0
0
46
428
1.08
0.16
4.4
1.9
—
—
—
0
0
30
273
1.11
0.16
4.5
5.2
0.00
0.70
%
—
7
83
43
399
1.09
0.16
4.5
1.9
—
—
—
0
0
252
2473
1.05
0.16
3.1
3.7
35.34
38.76
u/l
0.44
247
2380
15
130
1.16
0.16
2.2
2.2
—
—
—
0
0
30
274
1.10
0.15
4.4
5.9
0.00
0.03
%
—
6
69
178
1826
0.96
0.15
6.3
7.8
0.73
0.69
%
0.45
170
1729
46
430
1.08
0.15
1.3
1.3
—
—
—
0
0
179
1835
0.96
0.15
6.3
7.8
8.55
8.54
%
0.03
172
1744
12
139
0.86
0.14
1.4
1.3
—
—
—
0
0
36
335
1.08
0.13
1.3
1.3
95.41
138.04
u/ml
0.41
13
131
9
110
0.81
0.13
2.8
4.0
3.62
9.83
umol/l
—
9
83
25
229
1.10
0.12
1.6
1.2
—
—
—
0
0
22
201
1.10
0.11
6.5
2.2
—
—
—
0
0
45
426
1.06
0.11
4.4
1.9
—
—
—
0
0
31
291
1.07
0.09
3.3
13.1
7.44
7.42
ph
1.64
20
146
10
87
1.15
0.09
7.8
7.4
—
—
—
0
0
52
543
0.95
0.09
2.9
9.3
1.17
1.16
mmol/l
0.10
45
509
248
2449
1.03
0.09
5.6
7.4
77.71
85.65
u/l
1.83
240
2324
69
714
0.96
0.09
4.4
4.4
—
—
—
0
0
6
54
1.11
0.09
2.7
3.8
35.67
39.37
%
—
6
54
14
154
0.91
0.08
1.3
1.5
—
—
—
0
0
10
88
1.14
0.08
1.0
1.2
—
—
—
0
0
6
70
0.86
0.07
6.3
3.7
3.01
3.88
e9/l
—
6
70
6
75
0.80
0.07
1.7
1.4
240.33
323.81
mu/l
—
6
62
121
1186
1.03
0.07
2.7
2.2
—
—
—
0
0
15
163
0.92
0.07
2.0
2.3
14.12
46.64
u/ml
1.46
15
156
8
94
0.85
0.06
4.1
2.8
840.25
2077.30
u/ml
—
8
82
17
182
0.93
0.05
1.0
1.1
0.78
0.91
g/l
2.57
17
182
46
445
1.04
0.05
1.8
1.7
—
—
—
0
0
15
139
1.08
0.05
2.1
1.6
—
16.00
—
0
6
81
793
1.03
0.05
4.5
4.3
2.91
10.50
mg/mmol
3.58
53
526
130
1319
0.98
0.05
5.9
7.5
—
—
—
0
0
81
794
1.02
0.05
3.7
3.7
19.36
70.15
mg/l
4.63
54
547
30
288
1.04
0.04
3.3
13.2
1.02
0.53
mmol/l
0.40
24
243
188
1897
0.98
0.04
6.0
7.6
32.40
31.03
%
0.95
181
1823
13
121
1.08
0.03
1.7
1.8
—
—
—
0
0
41
400
1.03
0.03
1.7
1.6
—
—
—
0
0
25
241
1.04
0.02
2.8
3.9
82.14
72.17
e9/l
0.20
17
155
13
138
0.94
0.02
2.7
1.7
—
—
—
0
0
17
178
0.95
0.02
1.0
1.1
1.45
1.53
g/l
0.72
17
178
125
1239
1.01
0.02
1.7
1.6
—
—
—
0
0
32
312
1.03
0.02
6.7
2.3
—
—
—
0
0
12
113
1.06
0.02
4.5
3.0
53.91
56.39
%
0.29
12
113
15
156
0.96
0.00
1.5
1.6
—
—
—
0
0
21
212
0.99
0.00
1.2
1.4
164.62
271.76
miu/ml
1.13
11
106
215
2151
1.00
0.00
8.3
10.4
3.69
3.82
e9/l
0.44
189
1833
68
675
1.01
0.00
3.3
2.9
177.88
88.95
ug/g
1.22
58
541
67
665
1.01
0.00
1.3
1.3
16.82
26.27
iu/ml
0.78
22
176
17
174
0.98
0.00
1.0
1.1
—
0.68
—
0
10
20
196
1.02
0.00
1.7
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
9.46
—
0
5
0
5
0.00
0.00
0.0
5.0
—
4.30
—
0
5
0
5
0.00
0.00
0.0
3.4
—
362.60
—
0
5
0
5
0.00
0.00
0.0
1.0
—
3.91
—
0
5
0
6
0.00
0.00
0.0
1.2
—
327.00
—
0
6
5
49
1.02
0.00
1.2
1.2
—
—
—
0
0
8
80
1.00
0.00
1.6
2.3
6.76
10.53
mg/l
—
8
75
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
56
0.89
-0.00
1.8
1.5
—
—
—
0
0
6
65
0.92
-0.00
1.0
2.4
—
—
—
0
0
72
720
1.00
-0.00
2.2
3.3
328.08
329.74
umol/l
0.06
66
654
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.3
—
32.78
—
0
9
6
62
0.97
-0.00
1.2
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
8
82
0.98
-0.00
2.9
1.7
0.25
1.15
ug/l
—
8
77
0
7
0.00
-0.00
0.0
9.9
—
25.63
—
0
7
7
72
0.97
-0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
13.61
—
0
8
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint K11_MN_PROGN_AND_SURGRT_INCLAVO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have K11_MN_PROGN_AND_SURGRT_INCLAVO.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: K11_MN_PROGN_AND_SURGRT_INCLAVO – Mandibular prognathia AND surgery (LeFortI or BSSO), including avohilmo

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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