≡ Risteys
R14

Documentation Changelog GitHub Contact & Feedback

Obstructive hydrocephalus

DOID EFO Endpoint Browser PheWeb

G6_HCOBSTR

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G91.1
  • Hospital discharge: ICD-9 — 3314
  • Cause of death: ICD-10 — G91.1
  • Cause of death: ICD-9 — 3314

2 out of 7 registries used, show all original rules.

664

4. Check minimum number of events

None

664

5. Include endpoints

None

664

6. Filter based on genotype QC (FinnGen only)

571

Control definitions (FinnGen only)

Control exclude
G6_HYDROCEPH

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G91
Name in latin
Hydrocephalia obstructiva

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5759 2782 2921
Only index persons 4149 2069 2080
Unadjusted period prevalence (%)
Whole population 0.08 0.08 0.08
Only index persons 0.08 0.08 0.08
Median age at first event (years)
Whole population 50.19 53.09 47.07
Only index persons 46.90 51.02 42.81

-FinnGen-

Key figures

All Female Male
Number of individuals 571 295 276
Unadjusted period prevalence (%) 0.12 0.10 0.13
Median age at first event (years) 55.42 52.26 58.80

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
589
Matched controls
5890
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G91.1
ICD-10 Finland
Obstructive hydrocephalus
+∞
307.7
553
*
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
+∞
305.7
266
*
G91.0
ICD-10 Finland
Communicating hydrocephalus
+∞
192.6
174
*
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
2386.1
182.1
167
*
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
+∞
176.1
160
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
12.2
174.6
216
267
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
+∞
154.1
141
*
AA1AA
NOMESCO Finland
Head X-ray examination
59.1
151.8
86
17
AA1AD
NOMESCO Finland
CT of head and brain
8.6
149.9
394
1119
AAF00
NOMESCO Finland
Ventriculostomy
903.4
147.9
139
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
16.6
142.9
131
100
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
39.6
112.8
70
20
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
+∞
92.1
86
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
6.9
91.3
172
330
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
+∞
89.9
84
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
12.9
85.9
88
79
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
908.3
82.6
79
*
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
30.9
76.7
51
18
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
+∞
75.7
71
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
8.5
74.5
106
148
ZXD05
NOMESCO Finland
Urgent procedure
4.4
70.6
305
1148
N03AX14
ATC
levetiracetam; systemic
11.9
68.5
73
69
AAF50
NOMESCO Finland
Third ventriculostomy
+∞
67.0
63
*
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
28.9
63.3
43
16
AAF15
NOMESCO Finland
Ventriculoatrial shunt
+∞
62.6
59
*
3314A
ICD-9 Finland
Other cerebral degenerations, Obstructive hydrocephalus
+∞
57.2
54
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.3
54.3
182
553
XA800
NOMESCO Finland
Neuropsychological investigation
7.2
53.7
87
139
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
11.4
53.4
58
56
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.0
50.0
187
611
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
12.6
49.6
50
43
G91.8
ICD-10 Finland
Other hydrocephalus
+∞
46.5
44
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
7.2
39.5
62
95
R51.80
ICD-10 Finland
Headache
3.5
38.6
167
591
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.4
38.4
179
664
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.7
38.2
98
238
N03AF02
ATC
oxcarbazepine; oral
7.9
37.9
54
74
ZXE10
NOMESCO Finland
More than one and less than three hours
3.0
36.7
289
1444
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
12.7
36.2
36
30
ZXC86
NOMESCO Finland
Use of endoscopic device
81.2
34.3
38
5
2132
FHL
Ventricular operators sunt
+∞
33.7
32
*
AA1BD
NOMESCO Finland
Extensive CT of head and brain
9.2
33.5
42
49
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
12.4
32.8
33
28
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
11.6
32.3
34
31
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
10.6
31.2
35
35
N03AG01
ATC
valproic acid; systemic, rectal
4.8
31.2
76
176
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
30.3
216
1002
K90
ICPC
Stroke/cerebrovascular accident
7.1
29.7
46
69
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
9.7
29.4
35
38
N18
ICPC
Paralysis/weakness
8.8
29.4
38
46
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
6.4
28.6
49
82
XCK00
NOMESCO Finland
Perimetry
4.8
28.2
69
160
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
8.9
28.1
36
43
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.8
28.1
67
152
ZXD35
NOMESCO Finland
Usual procedure
6.6
27.0
45
73
AAA20
NOMESCO Finland
Insertion of intraventricular pressure monitoring device
283.4
26.9
27
*
ZXE20
NOMESCO Finland
More than three and less than five hours
3.1
25.6
125
466
N03AB02
ATC
phenytoin; systemic
9.8
25.5
30
32
H47.2
ICD-10 Finland
Optic atrophy
60.9
25.2
29
5
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.8
25.0
84
247
L28
ICPC
Limited function/disability (L)
2.8
24.5
158
685
2133
FHL
Suntin revisio
+∞
24.1
23
*
R42
ICD-10 Finland
Dizziness and giddiness
2.6
23.2
182
869
3313A
ICD-9 Finland
Other cerebral degenerations, Communicating hydrocephalus
+∞
23.1
22
*
Z2445
NOMESCO Finland
Psychologist
4.3
22.5
61
153
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
7.4
22.3
33
47
Q03.0
ICD-10 Finland
Malformations of aqueduct of Sylvius
+∞
22.0
21
*
Z98.2
ICD-10 Finland
Presence of cerebrospinal fluid drainage device
228.1
21.7
22
*
N28
ICPC
Limited function/disability (N)
7.8
21.4
30
40
SPAT1229
SPAT
Assessment of need for aid
3.8
21.3
71
207
G97.2
ICD-10 Finland
Intracranial hypotension following ventricular shunting
+∞
21.0
20
*
H02AB02
ATC
dexamethasone; systemic
3.0
20.2
99
367
N29
ICPC
Neurological sympt/complt other
7.6
20.1
29
40
N03AF01
ATC
carbamazepine; oral, rectal
4.3
20.0
55
139
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.6
20.0
71
216
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
25.6
19.7
27
11
TAB00
NOMESCO Finland
Lumbar puncture
4.3
19.7
53
132
2130
FHL
Ventricular atrial shunt
+∞
18.8
18
*
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
7.6
18.8
27
37
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.4
18.7
158
770
D43.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, infratentorial
103.4
18.7
20
*
D33.30
ICD-10 Finland
Acoustic neuroma
27.7
17.9
24
9
D33.07
ICD-10 Finland
Colloid coast in cerebral ventricle
185.3
17.6
18
*
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
7.4
17.1
25
35
A28
ICPC
Limited function/disability NOS
2.4
17.1
142
685
H53.2
ICD-10 Finland
Diplopia
4.9
17.1
38
81
H53.4
ICD-10 Finland
Visual field defects
6.3
17.0
29
48
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
7.2
16.7
25
36
Z3229
NOMESCO Finland
Other healthcare associate professional
3.0
16.3
76
273
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
7.3
16.2
24
34
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.8
16.1
91
363
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.5
16.0
57
173
R4120
NOMESCO Finland
Occupational therapy
3.4
15.8
61
195
AAA10
NOMESCO Finland
Biopsy through craniotomy
+∞
15.7
15
*
G81.1
ICD-10 Finland
Spastic hemiplegia
+∞
15.7
15
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.9
15.2
80
307
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.3
15.2
138
689
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
4.1
15.1
42
107
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.0
15.0
73
268
WX872
NOMESCO Finland
Intensive care
3.8
15.0
47
131
N99
ICPC
Neurological disease other
11.7
14.9
27
24
I62.0
ICD-10 Finland
Nontraumatic subdural haemorrhage
19.0
14.8
22
12
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
4.5
14.8
37
87
H02AB09
ATC
hydrocortisone; systemic
4.7
14.6
34
75
G91
ICD-10 Finland
Hydrocephalus
+∞
14.6
14
*
P20
ICPC
Memory disturbance
2.5
14.5
105
473
ZXA00
NOMESCO Finland
Right side
2.1
13.9
178
1013
Q03.9
ICD-10 Finland
Congenital hydrocephalus, unspecified
+∞
13.6
13
*
C71.90
ICD-10 Finland
Malignant tumor in unspecified localization in the brain without histology
34.9
13.6
17
5
C71.60
ICD-10 Finland
Malignant tumor of cerebellum without histology
143.2
13.5
14
*
SPAT1231
SPAT
Assessment of adjustments needed in living environment
6.3
13.5
23
38
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
6.5
13.4
22
35
SPAT1216
SPAT
Assessment of functional ability
2.3
13.1
111
534
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
13.4
13.0
22
17
N05BA09
ATC
clobazam; oral
13.4
13.0
22
17
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
5.8
13.0
24
43
D33.00
ICD-10 Finland
Medial pilosytic astrocytoma of the cerebrum
51.2
12.9
15
*
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
10.8
12.9
24
23
G93.0
ICD-10 Finland
Cerebral cysts
24.9
12.5
17
7
M03BX01
ATC
baclofen; systemic
5.8
12.5
23
41
G80.2
ICD-10 Finland
Spastic hemiplegic cerebral palsy
132.7
12.5
13
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.6
12.4
75
308
ZSA00
NOMESCO Finland
Procedure related to previous procedure classified in chapter A
38.4
12.3
15
*
130
Kela drug reimbursment
Malignant tumour
2.8
12.2
67
262
WX730
NOMESCO Finland
Conventional respirator
9.6
12.1
24
26
GBB00
NOMESCO Finland
Tracheostomy
12.1
11.9
21
18
183
Kela drug reimbursment
Lamotrigin and topiramate
9.9
11.8
23
24
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.7
11.8
38
108
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.2
11.7
108
538
A06AD11
ATC
lactulose; oral
2.2
11.6
105
518
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
5.4
11.6
23
44
JDB10
NOMESCO Finland
Percutaneous gastrostomy
10.3
11.6
22
22
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
4.7
11.5
27
60
2139
FHL
Other measure in this category
+∞
11.5
11
*
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
12.1
11.4
20
17
WX882
NOMESCO Finland
High dependency care
3.7
11.2
36
102
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
20.5
11.2
16
8
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.4
11.1
86
397
WX402
NOMESCO Finland
General anaesthesia
2.0
11.0
142
804
R11
ICD-10 Finland
Nausea and vomiting
2.5
10.9
73
315
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
15.9
10.9
17
11
101
Kela drug reimbursment
Anterior pituitary hypofunction
10.9
10.8
20
19
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
10.9
10.8
20
19
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
13.2
10.7
18
14
N03AX18
ATC
lacosamide; systemic
13.2
10.7
18
14
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.4
10.7
79
357
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
11.5
10.6
19
17
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.6
10.6
64
263
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
10.6
231
1548
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
7.9
10.5
23
30
AAL00
NOMESCO Finland
Endovascular occlusion of intracranial aneurysm
111.9
10.5
11
*
7423A
ICD-9 Finland
Other congenital anomalies of nervous system, Congenital hydrocephalus
+∞
10.4
10
*
C71.69
ICD-10 Finland
Malignant tumor of the cerebellum other or unspecified histology
+∞
10.4
10
*
G40.10
ICD-10 Finland
Simple partial seizures
16.4
10.4
16
10
R4110
NOMESCO Finland
Physiotherapy
1.9
10.3
177
1099
D43.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Central nervous system, unspecified
23.8
10.3
14
6
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
10.3
141
813
L01AX03
ATC
temozolomide; systemic
13.4
10.2
17
13
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
5.4
10.2
20
38
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
11.6
10.1
18
16
ZXC95
NOMESCO Finland
Use of surgical navigator
9.4
10.1
20
22
I60.7
ICD-10 Finland
Subarachnoid haemorrhage from intracranial artery, unspecified
40.8
10.0
12
*
E23.00
ICD-10 Finland
Panhypopituitarism
26.5
9.8
13
5
PA2KT
NOMESCO Finland
Endovascular closure of brain aneurysm
26.5
9.8
13
5
G46.4*I67.9
ICD-10 Finland
Cerebellar stroke syndrome
20.4
9.8
14
7
F83
ICD-10 Finland
Mixed specific developmental disorders
10.9
9.8
18
17
Z51.5
ICD-10 Finland
Palliative care
2.5
9.8
62
261
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
13.7
9.7
16
12
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
55.9
9.7
11
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.4
9.7
73
333
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
11.6
9.6
17
15
G41.9
ICD-10 Finland
Status epilepticus, unspecified
15.3
9.6
15
10
I61.5
ICD-10 Finland
Intracerebral haemorrhage, intraventricular
101.6
9.4
10
*
9560/0-C72.4
ICD-O-3
Schwannoma, NOS, of acoustic nerve
30.6
9.4
12
*
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
12.6
9.4
16
13
34793
ICD-8 Finland
Other disease of brain, Hydrocephalus acquisitus NUD
+∞
9.4
9
*
G91.3
ICD-10 Finland
Post-traumatic hydrocephalus, unspecified
+∞
9.4
9
*
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
+∞
9.4
9
*
P52.2
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 3, and grade 4 of fetus and newborn
+∞
9.4
9
*
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
14.0
9.2
15
11
AAD10
NOMESCO Finland
Evacuation of chronic subdural haematoma
7.9
9.2
20
26
R41.0
ICD-10 Finland
Disorientation, unspecified
3.6
9.2
30
86
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
4.7
9.1
21
46
WX892
NOMESCO Finland
Monitored bed care
2.6
9.1
56
232
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.6
9.1
56
232
R1250
NOMESCO Finland
Evaluation of functional capability
4.0
9.0
26
68
AAG00
NOMESCO Finland
Stereotactic intracranial biopsy
37.3
9.0
11
*
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
8.1
8.9
19
24
I60.2
ICD-10 Finland
Subarachnoid haemorrhage from anterior communicating artery
12.8
8.9
15
12
I60.1
ICD-10 Finland
Subarachnoid haemorrhage from middle cerebral artery
12.8
8.9
15
12
H50.2
ICD-10 Finland
Vertical strabismus
12.8
8.9
15
12
Z3226
NOMESCO Finland
Physiotherapist
1.9
8.9
123
708
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.9
8.9
41
146
H47.1
ICD-10 Finland
Papilloedema, unspecified
10.9
8.8
16
15
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.8
8.7
46
176
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.1
8.7
91
474
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
9.2
8.6
17
19
WX704
NOMESCO Finland
Intubation
2.5
8.5
55
233
I61.4
ICD-10 Finland
Intracerebral haemorrhage in cerebellum
28.0
8.5
11
*
P85
ICPC
Mental retardation
20.4
8.5
12
6
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
4.4
8.5
21
49
PA2AD
NOMESCO Finland
CT angiography of brain
13.0
8.4
14
11
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
13.0
8.4
14
11
AAA50
NOMESCO Finland
Intracranial endoscopy
+∞
8.3
8
*
D33.12
ICD-10 Finland
Cerebellum
+∞
8.3
8
*
74209
ICD-8 Finland
Congenital hydrocephalus, Unspecified
+∞
8.3
8
*
D32.06
ICD-10 Finland
Benign tumor of the meninges os petrosum or clivus area
+∞
8.3
8
*
AAF45
NOMESCO Finland
Fenestration of intracranial cyst
+∞
8.3
8
*
CBK11
NOMESCO Finland
Operation for lagophtalmus with implant
+∞
8.3
8
*
N03AX09
ATC
lamotrigine; oral
3.0
8.3
37
129
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.7
8.3
196
1325
XX4AW, ,
NOMESCO Finland
14.7
8.2
13
9
TPH07
NOMESCO Finland
Cathetrisation of artery
2.2
8.1
76
379
R27.0
ICD-10 Finland
Ataxia, unspecified
17.5
8.1
12
7
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
17.5
8.1
12
7
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
4.4
8.0
20
47
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
3.2
7.9
31
100
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
3.1
7.9
33
111
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.6
7.8
46
187
R1260
NOMESCO Finland
Evaluation of communicative skills
4.0
7.8
22
57
D32.9
ICD-10 Finland
Benign neoplasm: Meninges, unspecified
15.3
7.7
12
8
R32
ICD-10 Finland
Unspecified urinary incontinence
3.8
7.7
23
62
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
4.6
7.7
18
40
D32.0
ICD-10 Finland
Benign neoplasm: Cerebral meninges
18.6
7.6
11
6
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
12.1
7.6
13
11
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
7.5
83
441
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
3.4
7.5
26
78
D33.10
ICD-10 Finland
Benign pilosytic astrocytoma of brain stem
81.1
7.4
8
*
H53.0
ICD-10 Finland
Amblyopia ex anopsia
7.8
7.4
16
21
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.3
7.4
60
282
G04BD07
ATC
tolterodine; oral
2.7
7.4
39
150
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
3.9
7.3
21
55
C71.1
ICD-10 Finland
Malignant neoplasm: Frontal lobe
+∞
7.3
7
*
3431A
ICD-9 Finland
Infantile cerebral palsy, Hemiplegic
+∞
7.3
7
*
74200
ICD-8 Finland
Congenital hydrocephalus, Communicans
+∞
7.3
7
*
G94.2
ICD-10 Finland
Hydrocephalus in other diseases classified elsewhere
+∞
7.3
7
*
T85.7
ICD-10 Finland
Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
+∞
7.3
7
*
C71.89
ICD-10 Finland
Overall malignant tumor of the brain other or unspecified histology
+∞
7.3
7
*
AAW99
NOMESCO Finland
Other intracranial operation
+∞
7.3
7
*
SPAT1221
SPAT
Guidance concerning rehabilitation services and livelihood
4.6
7.2
17
38
H02.2
ICD-10 Finland
Lagophthalmos
30.4
7.2
9
*
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.4
7.0
25
76
ZXE00
NOMESCO Finland
One hour or less
1.6
7.0
220
1586
SPAT1252
SPAT
Overall medication plan or its review
2.4
6.8
45
193
G40.89
ICD-10 Finland
Other epilepsy
11.1
6.8
12
11
RT150, ,
NOMESCO Finland
11.1
6.8
12
11
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
4.3
6.8
17
40
D33.39
ICD-10 Finland
Benign tumor of the cranial nerves UNS
40.5
6.8
8
*
C71.70
ICD-10 Finland
Malignant tumor of the brainstem without histology
40.5
6.8
8
*
RT490, ,
NOMESCO Finland
40.5
6.8
8
*
E22.80
ICD-10 Finland
Central precocious puberty
40.5
6.8
8
*
AAB30
NOMESCO Finland
Evacuation of spontaneous intracranial haematoma
40.5
6.8
8
*
I60.0
ICD-10 Finland
Subarachnoid haemorrhage from carotid siphon and bifurcation
16.9
6.8
10
6
C71.10
ICD-10 Finland
Malignant tumor in frontal lobe without histology
16.9
6.8
10
6
H50.31
ICD-10 Finland
Intermittent exotropia
7.3
6.7
15
21
XXA00
NOMESCO Finland
Clinical examination requiring general anaesthesia
10.2
6.6
12
12
H50.1
ICD-10 Finland
Divergent concomitant strabismus
10.2
6.6
12
12
H01AC01
ATC
somatropin; parenteral
7.0
6.5
15
22
R47.0
ICD-10 Finland
Dysphasia and aphasia
7.0
6.5
15
22
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.9
6.5
90
515
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
5.8
6.5
17
30
K91
ICPC
Cerebrovascular disease
5.8
6.5
17
30
ZXD00
NOMESCO Finland
Emergency procedure
3.5
6.5
22
65
R4150
NOMESCO Finland
Neuropsychological rehabilitation
7.5
6.4
14
19
D33.7
ICD-10 Finland
Benign neoplasm: Other specified parts of central nervous system
70.6
6.4
7
*
I60.4
ICD-10 Finland
Subarachnoid haemorrhage from basilar artery
70.6
6.4
7
*
Q04.6
ICD-10 Finland
Congenital cerebral cysts
70.6
6.4
7
*
G81.0
ICD-10 Finland
Flaccid hemiplegia
70.6
6.4
7
*
AWB00
NOMESCO Finland
Reoperation for superficial infection in surgery of the nervous system
70.6
6.4
7
*
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.2
6.4
57
278
R50.9
ICD-10 Finland
Fever, unspecified
1.8
6.4
101
603
L89
ICD-10 Finland
Decubitus ulcer and pressure area
4.1
6.4
17
42
Z3231
NOMESCO Finland
Registered nurse
1.6
6.4
167
1147
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
8.3
6.4
13
16
H49.1
ICD-10 Finland
Fourth [trochlear] nerve palsy
11.2
6.3
11
10
G80.0
ICD-10 Finland
Spastic quadriplegic cerebral palsy
+∞
6.3
6
*
CBH30
NOMESCO Finland
Tarsorraphy
+∞
6.3
6
*
9161/1-C71.6
ICD-O-3
Hemangioblastoma of cerebellum, NOS
+∞
6.3
6
*
D33.08
ICD-10 Finland
Another benign tumor of the cerebral ventricle
+∞
6.3
6
*
Q05.2
ICD-10 Finland
Lumbar spina bifida with hydrocephalus
+∞
6.3
6
*
D44.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pineal gland
+∞
6.3
6
*
Q85.01
ICD-10 Finland
Neurofibromatosis, type 2
+∞
6.3
6
*
R4130
NOMESCO Finland
Speech therapy
3.2
6.2
24
77
U04
ICPC
Incontinence urine
2.4
6.1
41
177
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
12.7
6.1
10
8
F54
ICD-10 Finland
Psychological and behavioural factors associated with disorders or diseases classified elsewhere
12.7
6.1
10
8
TJD20
NOMESCO Finland
Change of gastrostomy tube
10.2
6.1
11
11

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
151
40
50.42
252.87
2.6
1.1
—
—
—
0
0
162
94
23.39
205.76
2.6
1.8
34.47
13.55
e6/l
0.83
125
69
162
96
22.90
203.70
2.6
1.9
1873.00
213.99
e6/l
1.18
129
73
148
87
22.38
186.15
2.7
2.0
—
—
—
0
0
110
38
35.37
169.14
2.7
2.4
—
—
—
0
0
90
51
20.65
113.47
2.8
2.5
—
—
—
0
0
153
549
3.41
34.20
12.3
9.4
1.47
0.95
mmol/l
0.89
124
461
152
553
3.36
33.14
12.5
9.4
7.42
7.42
ph
0.23
98
326
223
1205
2.37
21.36
2.8
2.5
—
—
—
0
0
270
1592
2.29
20.98
3.1
2.5
—
—
—
0
0
259
1518
2.26
20.23
3.0
2.2
378.99
245.82
u/l
0.47
247
1445
335
2298
2.06
16.24
11.4
7.4
1.19
1.21
mmol/l
6.46
312
2118
214
1245
2.13
16.22
5.1
4.6
89.71
88.89
%
0.21
208
1222
322
2252
1.95
13.96
3.4
2.9
—
—
estimate
—
0
0
348
2547
1.90
12.64
10.9
7.8
1.20
1.21
mmol/l
2.13
318
2208
387
2942
1.92
12.38
10.1
5.5
6.74
6.60
mmol/l
0.67
382
2786
219
1399
1.90
12.00
5.2
4.5
—
—
—
0
0
69
282
2.64
11.55
10.4
5.8
—
—
—
0
0
311
2279
1.77
10.45
13.6
13.8
1.18
1.24
inr
1.43
269
1905
144
837
1.95
10.24
4.0
4.3
0.85
0.82
mmol/l
1.98
136
795
97
495
2.15
9.81
13.7
10.1
—
—
—
0
0
107
1815
0.50
9.70
2.9
3.2
—
—
—
0
0
217
1480
1.74
9.02
5.5
3.3
—
—
—
0
0
126
742
1.89
8.47
2.7
2.0
—
—
—
0
0
25
70
3.69
7.93
1.5
1.7
23.66
26.17
ng/l
0.17
25
70
119
720
1.82
7.26
5.4
7.1
1.00
1.09
mmol/l
2.66
111
667
101
605
1.81
6.33
2.3
1.7
—
—
—
0
0
280
2181
1.54
6.17
5.6
5.5
34.57
36.04
g/l
4.05
264
2059
96
575
1.80
6.00
5.5
5.0
1.39
1.70
mmol/l
0.30
88
480
89
525
1.82
5.85
3.9
2.2
336.14
385.91
nmol/l
1.96
83
495
72
401
1.91
5.66
2.4
2.4
7.52
7.27
ug/l
0.03
57
356
98
604
1.75
5.55
5.0
5.0
7.38
7.38
ph
0.06
64
376
43
206
2.17
5.10
2.3
3.3
20.79
21.52
s
0.54
38
192
37
167
2.30
5.05
10.2
3.2
1.49
1.39
mmol/l
0.19
37
161
43
208
2.15
4.98
2.3
1.8
0.28
2.78
ug/l
1.22
35
189
124
838
1.61
4.93
1.9
1.8
1224.31
1170.41
nmol/l
0.28
99
641
216
1657
1.48
4.79
4.8
3.6
21.63
97.34
e6/l
1.21
180
1264
141
992
1.55
4.70
3.8
3.1
525.64
534.98
mosm/kgh2o
0.19
129
868
70
411
1.80
4.67
1.4
1.5
—
—
—
0
0
10
14
7.25
4.67
1.6
1.3
—
—
—
0
0
157
1138
1.52
4.55
3.6
2.8
5.34
6.12
e6/l
0.24
148
1038
22
82
2.75
4.46
1.3
1.7
—
—
—
0
0
22
82
2.75
4.46
1.3
1.7
—
—
—
0
0
22
82
2.75
4.46
1.3
1.7
—
—
—
0
0
22
82
2.75
4.46
1.3
1.7
—
—
—
0
0
34
159
2.21
4.30
3.7
1.7
4.09
7.57
u/l
3.73
27
117
54
908
0.55
4.21
1.4
1.3
29.98
32.30
iu/ml
0.06
18
274
218
1709
1.44
4.20
4.0
3.3
2.35
2.36
mmol/l
0.67
193
1558
371
3206
1.42
4.09
7.3
4.8
3031.33
1825.85
e6/l
—
9
61
17
428
0.38
4.06
1.5
1.4
—
—
—
0
0
185
1418
1.44
3.99
4.5
3.5
0.45
0.43
e6/l
0.06
149
1040
176
1342
1.44
3.89
4.4
3.4
—
0.00
estimate
—
0
7
417
4568
0.70
3.60
4.5
5.0
1.39
1.45
mmol/l
2.48
389
4245
51
832
0.58
3.54
1.3
1.3
14.19
9.31
u/ml
0.32
20
308
11
27
4.13
3.41
1.5
1.1
0.55
0.53
ratio
—
5
16
15
53
2.88
3.38
2.5
2.7
36.23
39.08
%
0.30
15
53
307
2618
1.36
3.37
7.7
7.1
11.70
11.66
umol/l
0.01
289
2493
429
4663
0.71
3.36
5.2
5.8
2.65
2.69
mmol/l
0.48
400
4334
156
1196
1.41
3.28
6.1
4.0
1.02
1.02
kg/l
0.58
116
796
404
4427
0.72
3.24
6.5
6.4
39.17
39.19
mmol/mol
0.02
380
4168
190
1518
1.37
3.10
3.9
4.4
7.40
7.39
ph
1.56
137
1077
31
160
1.99
3.10
2.6
1.5
317.74
301.87
mu/l
0.12
31
149
424
4590
0.73
2.92
4.6
5.2
4.47
4.60
mmol/l
1.74
392
4294
131
995
1.41
2.88
3.3
2.8
2.45
2.45
mmol/l
0.04
115
893
16
66
2.46
2.73
2.0
2.5
—
—
—
0
0
7
200
0.34
2.71
2.0
1.8
—
—
—
0
0
128
979
1.39
2.69
3.8
4.0
204.61
379.86
ng/l
0.67
98
767
227
1897
1.32
2.68
5.9
4.3
82.05
91.21
e6/l
0.13
178
1335
402
4369
0.75
2.66
3.9
4.3
1.30
1.28
mmol/l
0.31
373
4038
15
61
2.50
2.64
5.5
1.7
9.80
10.44
mmol/l
0.36
15
61
130
1008
1.37
2.51
1.6
1.8
414.88
19693837.40
pmol/l
0.72
107
848
225
1892
1.31
2.50
4.1
3.9
35.41
66.90
ng/l
0.52
172
1355
109
823
1.40
2.47
4.3
3.4
4.66
1.90
e6/l
1.12
60
413
34
198
1.76
2.41
3.0
4.1
414.30
278.65
mg/l
0.31
23
89
6
12
5.04
2.40
1.2
1.4
—
—
—
0
0
39
610
0.61
2.30
1.6
1.6
—
—
—
0
0
36
218
1.69
2.24
2.9
1.6
16.39
22.62
iu/l
0.65
31
172
5
9
5.59
2.21
2.2
1.2
—
—
—
0
0
169
2022
0.77
2.17
2.0
2.0
1.31
1.36
mmol/l
0.44
150
1703
423
4517
0.77
2.03
4.8
5.0
5.96
5.92
mmol/l
0.27
396
4150
8
26
3.10
2.02
2.0
2.1
488.25
898.54
u/ml
—
8
26
31
493
0.61
1.98
1.2
1.5
—
—
—
0
0
50
709
0.68
1.89
1.3
1.4
1146.67
501.82
titre
—
9
154
48
682
0.68
1.83
1.2
1.3
—
—
—
0
0
183
1551
1.26
1.82
9.8
6.5
—
—
—
0
0
506
5256
0.74
1.77
36.8
24.5
131.10
135.32
g/l
7.60
501
5202
9
194
0.46
1.75
1.2
1.1
—
—
—
0
0
6
18
3.36
1.75
1.0
1.0
1732.00
1455.11
miu/ml
—
6
18
506
5254
0.74
1.74
36.5
24.3
7.35
6.76
e9/l
6.09
496
5140
506
5253
0.74
1.72
36.4
24.1
29.91
30.23
pg
3.28
500
5201
506
5253
0.74
1.72
36.5
24.2
4.43
4.51
e12/l
2.59
497
5142
506
5253
0.74
1.72
37.8
24.8
39.32
40.33
%
4.63
500
5197
5
13
3.87
1.72
1.4
2.3
21.36
17.41
umol/l
—
5
13
506
5251
0.74
1.69
36.5
24.3
266.68
249.61
e9/l
5.10
497
5155
506
5251
0.74
1.69
36.5
24.2
89.94
90.72
fl
3.10
500
5200
7
156
0.44
1.57
1.3
1.1
1.67
1.53
g/l
—
7
156
10
205
0.48
1.54
1.4
1.4
—
—
—
0
0
64
481
1.37
1.53
2.3
2.5
30.96
32.69
u/l
0.19
49
394
7
27
2.61
1.52
4.4
2.3
—
—
—
0
0
64
483
1.36
1.49
1.9
2.9
0.19
0.22
g/l
2.32
59
456
40
562
0.69
1.47
1.3
1.4
—
—
—
0
0
106
863
1.28
1.46
2.6
2.6
11.47
13.21
umol/l
1.56
96
810
237
2107
1.21
1.45
4.7
3.5
6.60
6.19
ph
6.40
137
1180
6
22
2.74
1.43
2.2
1.8
184.50
142.66
ng/l
—
6
17
6
22
2.74
1.43
1.2
1.1
—
—
—
0
0
9
40
2.27
1.40
5.6
2.8
0.33
0.80
index
—
9
40
10
46
2.19
1.40
1.8
1.2
3.45
3.50
ug/l
—
10
41
8
161
0.49
1.38
1.3
1.1
0.78
0.92
g/l
—
8
161
8
163
0.48
1.37
1.6
2.4
—
—
—
0
0
81
642
1.30
1.37
2.4
3.4
1.84
1.77
%
0.26
69
586
5
17
2.96
1.36
3.2
3.7
41.40
44.06
%
—
5
17
5
17
2.96
1.36
6.4
7.4
7.40
9.82
%
—
5
17
0
37
0.00
1.35
0.0
1.3
—
—
—
0
0
201
1770
1.21
1.34
7.3
6.7
—
—
—
0
0
33
225
1.49
1.34
13.3
4.4
9.58
8.83
kpa
1.59
33
217
72
907
0.77
1.33
3.1
3.1
0.65
0.79
ug/l
1.19
48
571
92
746
1.28
1.31
2.7
2.7
20.46
22.87
%
0.89
84
704
46
337
1.40
1.30
3.5
3.9
129.59
128.64
g/l
0.10
46
328
12
62
1.95
1.28
1.3
1.2
—
—
—
0
0
31
211
1.50
1.28
1.9
1.9
—
—
—
0
0
6
25
2.41
1.24
2.2
3.4
72.17
178.88
nmol/l
—
6
25
137
1588
0.82
1.23
4.1
4.2
8.44
9.70
mg/mmol
0.15
92
1014
135
1564
0.82
1.20
3.4
3.5
58.34
55.65
mg/l
0.05
95
1036
98
811
1.25
1.19
2.6
2.6
2.25
2.31
g/l
0.54
90
756
57
440
1.33
1.18
1.8
2.1
0.00
0.03
estimate
—
10
90
54
694
0.76
1.17
2.3
2.8
386.34
127.05
ug/g
0.91
41
556
315
2924
1.17
1.08
12.2
10.1
4.62
4.06
e9/l
2.56
277
2551
13
217
0.59
1.08
1.0
1.7
—
15.69
—
0
8
37
496
0.73
1.07
1.4
1.6
—
—
—
0
0
153
1734
0.84
1.07
3.5
3.5
7.44
7.73
mmol/l
0.30
133
1471
10
52
1.94
1.06
1.2
1.1
—
—
—
0
0
22
146
1.53
1.04
5.5
3.0
1.50
2.50
index
0.61
12
88
13
214
0.60
1.03
1.1
1.3
—
—
—
0
0
5
107
0.46
1.02
1.0
1.0
—
17.16
—
0
30
5
23
2.18
0.98
1.4
1.1
139.20
134.04
nmol/l
—
5
23
28
385
0.71
0.96
8.7
3.8
—
—
—
0
0
163
1450
1.17
0.95
6.3
3.9
0.00
0.01
estimate
0.78
48
492
42
323
1.32
0.92
10.2
4.5
—
—
—
0
0
165
1474
1.17
0.91
1.7
1.7
20.47
20.58
nmol/l
0.03
146
1237
289
2691
1.15
0.90
8.4
6.7
1.97
1.95
e9/l
0.04
254
2377
156
1391
1.17
0.88
1.5
1.4
—
—
—
0
0
128
1446
0.85
0.85
5.1
3.3
0.00
0.07
estimate
0.58
40
428
240
2220
1.14
0.80
2.8
2.7
73.77
76.00
nmol/l
0.57
218
2009
11
175
0.62
0.79
1.6
1.5
656.51
989.81
mu/l
1.18
11
151
16
233
0.68
0.78
1.5
1.5
0.36
0.31
mg/l
—
9
99
0
27
0.00
0.77
0.0
1.8
—
—
—
0
0
390
3727
1.14
0.77
9.0
8.4
86.93
81.99
u/l
0.99
371
3522
101
1150
0.85
0.74
6.6
5.1
—
—
—
0
0
489
5017
0.85
0.74
13.8
12.2
27.91
26.11
u/l
1.14
476
4887
8
136
0.58
0.73
1.0
1.1
—
—
—
0
0
15
100
1.51
0.73
4.4
3.5
—
—
—
0
0
174
1585
1.14
0.73
2.8
2.6
50.54
63.61
u/l
2.25
162
1472
35
443
0.78
0.72
4.9
5.0
0.06
0.16
%
0.48
16
129
52
427
1.24
0.72
10.1
4.3
7.40
7.42
ph
0.98
45
347
74
631
1.20
0.72
2.4
3.7
18.19
8.61
umol/l
0.89
61
558
34
431
0.78
0.71
4.9
4.6
1.13
0.45
%
0.72
16
146
279
2622
1.12
0.70
5.8
3.9
0.00
2.97
estimate
0.50
56
548
306
3228
0.89
0.70
3.4
3.6
49.73
47.13
u/l
0.27
290
3046
185
1697
1.13
0.70
3.5
3.6
34.67
31.78
u/l
0.17
175
1616
36
451
0.79
0.69
1.3
1.8
—
—
—
0
0
11
69
1.61
0.68
1.0
1.1
—
—
—
0
0
7
42
1.67
0.68
3.3
2.6
—
—
—
0
0
24
317
0.75
0.68
1.3
1.2
—
—
—
0
0
110
1234
0.87
0.67
2.4
3.1
331.02
346.13
umol/l
0.88
100
1085
5
94
0.53
0.67
1.4
1.5
—
—
—
0
0
27
349
0.76
0.66
1.1
1.2
235.91
148.28
u/ml
—
7
139
72
618
1.19
0.66
3.2
3.1
8.87
5.20
e9/l
0.43
63
550
10
154
0.64
0.65
1.5
1.1
—
—
—
0
0
21
278
0.75
0.62
1.1
1.2
—
13.50
titre
—
0
6
351
3359
1.11
0.61
6.3
4.7
—
2.40
—
0
9
17
232
0.72
0.61
1.2
1.8
—
—
—
0
0
0
20
0.00
0.60
0.0
1.4
—
27.00
—
0
20
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.7
—
11.44
—
0
15
280
2649
1.11
0.60
5.8
4.0
0.00
0.60
estimate
0.51
50
515
25
192
1.32
0.60
2.6
2.8
—
—
—
0
0
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
21
157
1.35
0.60
1.2
1.4
315.07
295.44
ug/g
0.21
15
89
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
213
1988
1.11
0.59
6.1
3.8
0.13
0.03
estimate
0.55
40
450
140
1528
0.89
0.57
4.9
5.2
1.74
2.33
ug/l
1.23
131
1376
17
229
0.73
0.57
1.2
1.8
—
—
—
0
0
17
229
0.73
0.57
1.2
1.8
—
—
—
0
0
148
1358
1.12
0.56
3.1
2.4
3.09
2.84
mg/l
0.53
128
1179
16
216
0.73
0.54
1.3
1.8
—
—
—
0
0
261
2471
1.10
0.54
8.4
6.7
2.41
2.91
%
3.34
246
2328
13
91
1.44
0.53
2.5
3.5
0.90
0.83
nmol/l
—
7
75
9
62
1.46
0.53
1.6
1.3
0.54
31.41
nmol/l
—
9
55
261
2473
1.10
0.53
8.5
6.8
0.60
0.69
%
1.85
246
2327
231
2176
1.10
0.53
2.3
2.2
91.19
96.30
pmol/l
0.89
126
1134
273
2595
1.10
0.51
5.7
3.9
0.02
0.00
estimate
0.49
54
534
265
2517
1.10
0.51
8.5
6.8
25.73
28.19
%
2.60
252
2406
279
2659
1.09
0.49
8.4
6.6
0.04
0.04
e9/l
0.20
241
2284
288
2749
1.09
0.49
8.8
6.9
0.17
0.20
e9/l
1.43
251
2399
278
2650
1.09
0.49
8.4
6.6
0.63
0.58
e9/l
1.26
239
2277
13
93
1.41
0.48
7.0
3.5
1.98
2.57
mmol/l
—
8
59
7
46
1.53
0.48
1.6
1.3
—
—
nmol/l
—
0
0
260
2474
1.09
0.47
8.6
6.9
8.72
8.86
%
0.32
244
2337
10
68
1.48
0.47
1.4
4.0
—
—
—
0
0
8
118
0.67
0.46
1.9
1.7
—
—
—
0
0
7
49
1.43
0.46
1.3
1.1
1.50
1.67
nmol/l
—
7
44
5
82
0.61
0.46
1.0
1.5
—
—
—
0
0
5
84
0.59
0.46
1.4
1.1
—
—
—
0
0
22
275
0.79
0.45
1.3
1.3
—
—
—
0
0
8
56
1.43
0.42
1.4
4.8
11.45
11.54
%
—
8
56
14
184
0.76
0.42
1.1
1.3
—
—
—
0
0
348
3364
1.08
0.42
3.7
4.1
—
0.29
—
0
7
5
32
1.57
0.42
1.0
1.5
89.20
77.09
umol/l
—
5
32
391
3799
1.09
0.41
4.5
4.2
15.10
14.76
pmol/l
1.84
363
3460
37
432
0.85
0.41
4.6
4.7
0.11
0.13
%
0.11
18
134
18
227
0.79
0.41
1.2
1.8
—
—
—
0
0
0
17
0.00
0.40
0.0
2.0
—
0.58
—
0
17
0
18
0.00
0.40
0.0
3.7
—
—
—
0
0
0
18
0.00
0.40
0.0
6.3
—
19.92
—
0
5
9
66
1.37
0.38
1.0
1.3
—
—
—
0
0
14
179
0.78
0.36
1.3
1.8
—
—
—
0
0
40
457
0.87
0.35
4.4
4.6
1.00
0.95
%
0.05
20
162
70
767
0.90
0.33
1.5
1.7
—
—
—
0
0
18
146
1.24
0.32
13.8
10.4
—
—
—
0
0
176
1849
0.93
0.32
2.2
2.1
—
—
—
0
0
118
1257
0.92
0.31
1.3
1.4
1.09
1.59
u/ml
0.36
27
312
418
4095
1.07
0.30
33.2
20.8
332.19
332.67
g/l
0.44
413
4075
54
487
1.12
0.30
2.6
3.2
72.31
69.65
e9/l
0.19
40
354
228
2369
0.94
0.30
3.4
3.1
120.49
120.59
ug/l
0.00
209
2215
21
249
0.84
0.29
3.0
2.4
—
—
—
0
0
8
107
0.74
0.29
1.1
1.9
—
—
—
0
0
7
57
1.23
0.29
1.7
1.9
2.89
0.83
mmol/l
—
7
57
8
62
1.29
0.28
2.1
2.2
—
—
—
0
0
9
116
0.77
0.27
1.4
1.7
—
—
—
0
0
31
353
0.87
0.27
1.3
2.7
—
—
—
0
0
8
64
1.25
0.27
1.8
1.6
41.56
33.23
g/l
—
8
58
8
66
1.22
0.27
1.0
1.1
—
—
—
0
0
109
1154
0.93
0.25
1.7
1.6
2.02
2.31
g/l
0.93
58
690
441
4475
0.94
0.23
5.4
5.2
1.90
1.93
mu/l
0.15
417
4128
10
125
0.80
0.23
1.3
1.6
—
—
—
0
0
255
2480
1.05
0.22
8.4
6.7
58.91
56.71
%
1.91
243
2378
0
11
0.00
0.21
0.0
3.5
—
—
—
0
0
0
12
0.00
0.21
0.0
2.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
47
511
0.91
0.21
4.5
4.3
7.63
28.58
ug/l
0.74
40
427
237
2303
1.05
0.21
13.3
11.4
0.00
0.00
e9/l
0.31
189
1864
11
134
0.82
0.21
5.6
2.8
53.91
57.84
%
0.29
11
134
136
1418
0.95
0.20
4.0
3.1
0.60
0.05
—
5
39
0
14
0.00
0.20
0.0
1.1
—
0.72
—
0
6
0
14
0.00
0.20
0.0
1.0
—
29.50
—
0
8
26
231
1.13
0.20
1.5
2.5
1.36
1.49
g/l
0.38
21
203
10
122
0.82
0.19
4.6
4.9
—
—
—
0
0
5
70
0.71
0.16
2.0
2.8
—
—
—
0
0
23
256
0.89
0.16
1.0
1.1
—
—
—
0
0
47
438
1.08
0.16
1.1
1.2
—
—
—
0
0
38
411
0.92
0.16
3.2
4.7
71.77
81.25
ng/l
0.43
33
361
490
4940
0.95
0.15
19.9
14.1
—
—
—
0
0
14
159
0.88
0.13
1.3
1.2
—
—
—
0
0
46
437
1.06
0.10
1.4
3.2
69.41
66.69
g/l
1.68
39
401
43
408
1.06
0.10
3.8
2.4
6.10
6.10
ph
0.00
30
279
5
46
1.09
0.09
1.0
1.1
68.40
109.04
pmol/l
—
5
46
6
55
1.09
0.09
1.7
1.7
—
—
—
0
0
6
57
1.05
0.08
1.5
1.5
—
—
—
0
0
5
60
0.83
0.08
1.0
1.3
—
—
—
0
0
10
88
1.14
0.08
3.5
3.2
4.27
4.25
e9/l
—
10
88
18
166
1.09
0.08
2.1
1.8
41.50
39.95
nmol/l
0.13
18
159
6
73
0.82
0.07
1.2
1.3
—
—
—
0
0
8
77
1.04
0.07
1.1
1.3
—
—
—
0
0
9
85
1.06
0.07
1.1
1.1
—
—
—
0
0
153
1508
1.02
0.05
3.0
3.4
1027.58
1411.88
ng/l
1.28
134
1288
485
4830
1.02
0.05
26.0
16.1
26.99
24.23
mg/l
1.09
417
3961
60
616
0.97
0.05
1.3
1.6
—
—
—
0
0
11
119
0.92
0.04
1.1
1.3
—
—
—
0
0
61
621
0.98
0.03
1.4
1.5
—
—
—
0
0
45
440
1.02
0.02
3.6
4.3
7.27
7.34
ph
0.56
30
320
24
232
1.04
0.02
1.8
2.2
0.11
0.01
estimate
—
9
71
11
117
0.94
0.01
1.4
1.3
—
—
—
0
0
60
593
1.01
0.01
1.3
1.3
—
—
—
0
0
40
395
1.01
0.00
1.2
1.5
—
—
—
0
0
92
916
1.01
0.00
1.5
2.0
—
—
—
0
0
114
1143
1.00
0.00
2.2
2.0
1.20
1.36
mg/l
0.34
91
888
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
9
98
0.92
-0.00
1.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.2
—
8111.89
—
0
9
6
66
0.91
-0.00
3.8
2.0
—
—
—
0
0
13
130
1.00
-0.00
2.1
1.8
222.00
225.58
pmol/l
0.05
13
120
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
9
91
0.99
-0.00
11.8
3.6
6.02
8.32
pmol/l
—
9
91
0
6
0.00
-0.00
0.0
1.8
—
7.88
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
55
0.91
-0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.7
—
—
—
0
0
5
51
0.98
-0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
52.00
—
0
8
0
6
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
19.18
—
0
6
0
7
0.00
-0.00
0.0
1.4
—
4.33
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
1.95
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
169.60
—
0
5

Mortality – FinRegistry

↥

Association

Association between endpoint G6_HCOBSTR and mortality.

Females

Parameter HR [95% CI] p-value
G6_HCOBSTR 4.198 [3.58, 4.93] < 0.001
Birth year 0.996 [0.99, 1.0] 0.317

During the follow-up period (1.1.1998 — 31.12.2019), 633 out of 1803 females with G6_HCOBSTR died.

Males

Parameter HR [95% CI] p-value
G6_HCOBSTR 4.142 [3.49, 4.92] < 0.001
Birth year 0.988 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 664 out of 1881 males with G6_HCOBSTR died.

Mortality risk

Mortality risk for people of age

years, who have G6_HCOBSTR.

N-year risk Females Males
1 0.303% 0.858%
5 2.097% 4.966%
10 5.729% 12.13%
15 11.161% 22.418%
20 19.411% 35.9%

Relationships between endpoints

↥

Index endpoint: G6_HCOBSTR – Obstructive hydrocephalus

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data