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Dermatitis herpetiformis

DOID EFO Endpoint Browser PheWeb

L12_DERMATHERP

dermatitis herpetiformis: Dermatitis herpetiformis (DH) is a chronic autoimmune subepidermal bullous disease characterized by grouped pruritic lesions such as papules, urticarial plaques, erythema, and herpetiform vesiculae, with a predominantly symmetrical distribution on extensor surfaces of the elbows (90%), knees (30%), shoulders, buttocks, sacral region, and face of children and adults. Erosions, excoriations and hyperpigmentation usually follow. DH may also appear as a consequence of gluten intolerance.

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Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L13.0
  • Hospital discharge: ICD-9 — 6940A|6942
  • Hospital discharge: ICD-8 — 693
  • Cause of death: ICD-10 — L13.0
  • Cause of death: ICD-9 — 6940A|6942
  • Cause of death: ICD-8 — 693

2 out of 7 registries used, show all original rules.

730

4. Check minimum number of events

None

730

5. Include endpoints

None

730

6. Filter based on genotype QC (FinnGen only)

662

Control definitions (FinnGen only)

Control exclude
L12_BULLOUS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L13
Name in latin
Dermatitis herpetiformis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4875 2511 2338
Only index persons 4281 2269 2012
Unadjusted period prevalence (%)
Whole population 0.07 0.07 0.07
Only index persons 0.08 0.08 0.08
Median age at first event (years)
Whole population 45.74 45.97 45.38
Only index persons 44.15 44.66 43.57

-FinnGen-

Key figures

All Female Male
Number of individuals 662 380 282
Unadjusted period prevalence (%) 0.13 0.13 0.13
Median age at first event (years) 45.37 41.63 50.42

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
674
Matched controls
6740
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K90.0
ICD-10 Finland
Coeliac disease
84.2
307.7
339
80
L13.0
ICD-10 Finland
Dermatitis herpetiformis
16384.0
307.7
554
*
J04BA02
ATC
dapsone; oral
966.9
220.1
204
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
9.7
156.9
228
339
69399
ICD-8 Finland
Dermatitis herpetiformis
+∞
138.4
128
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.8
62.6
330
1371
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.5
48.4
235
900
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
3.8
44.3
164
523
D07AC01
ATC
betamethasone; topical
3.0
43.9
352
1785
D07AC13
ATC
mometasone; topical
3.0
40.2
284
1330
D07AB02
ATC
hydrocortisone butyrate; topical
2.9
38.3
287
1379
E000001, ,
ATC
3.2
38.2
204
812
6940A
ICD-9 Finland
Bullous dermatoses, Dermatitis herpetiformis
+∞
31.5
30
*
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.7
29.6
107
330
D07AB08
ATC
desonide; topical
3.3
28.8
123
422
E0000UV, ,
ATC
2.4
26.0
342
2052
E000002, ,
ATC
3.2
25.7
113
394
D07AD01
ATC
clobetasol; topical
2.8
25.5
163
699
D07CC01
ATC
betamethasone and antibiotics; topical
2.8
20.8
122
497
QCA99
NOMESCO Finland
Other local destruction of skin of upper limb
113.6
20.7
22
*
L13.9
ICD-10 Finland
Bullous disorder, unspecified
56.7
19.0
22
*
R06AE07
ATC
cetirizine; oral
2.1
18.8
325
2091
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.0
18.3
55
148
RD210, ,
NOMESCO Finland
7.5
17.9
26
36
TQW80
NOMESCO Finland
Local dermatologic skincare
5.5
17.2
34
65
R06AE09
ATC
levocetirizine; oral
2.5
16.8
121
543
D07XB05
ATC
dexamethasone; topical
4.7
16.3
38
84
L20.0
ICD-10 Finland
Besnier prurigo
3.1
16.0
73
258
D09AB01
ATC
zinc bandage without supplements; topical
6.2
15.2
26
43
E000007, ,
ATC
3.4
15.0
57
180
K90.9
ICD-10 Finland
Intestinal malabsorption, unspecified
32.5
14.9
19
6
L12.0
ICD-10 Finland
Bullous pemphigoid
81.9
14.6
16
*
H02AB06
ATC
prednisolone; systemic
1.9
14.5
349
2444
D07BC01
ATC
betamethasone and antiseptics; topical
2.5
13.7
99
442
L30.3
ICD-10 Finland
Infective dermatitis
3.9
13.6
41
111
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.6
12.8
81
340
D02AX
ATC
Other emollients and protectives
4.4
12.6
32
76
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
12.1
254
1678
107
Kela drug reimbursment
Pernicious anaemia
5.5
11.9
23
43
R06AX13
ATC
loratadine; oral
2.2
11.8
117
597
D07AA02
ATC
hydrocortisone; topical
2.2
11.6
115
586
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
5.5
11.4
22
41
R06AX27
ATC
desloratadine; oral
1.8
10.4
194
1227
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.7
10.4
299
2140
L29.9
ICD-10 Finland
Pruritus, unspecified
3.8
10.2
31
84
S02
ICPC
Pruritus
3.3
10.2
39
124
D02AE01
ATC
carbamide; topical
2.7
10.1
54
208
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.1
9.5
99
514
69300, ,
ICD-8 Finland
+∞
9.4
9
*
D07XC01
ATC
betamethasone; topical
2.1
9.4
97
501
N05BB01
ATC
hydroxyzine; systemic
2.6
9.3
54
217
J05AB01
ATC
aciclovir; systemic
1.8
9.0
162
1009
XQ848
NOMESCO Finland
Dermatological photography
3.5
8.7
30
89
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
7.1
8.6
20
29
E000006, ,
ATC
2.5
8.6
56
238
K29.4
ICD-10 Finland
Chronic atrophic gastritis
4.3
8.5
22
53
SPAT1263
SPAT
Sampling
1.6
8.5
281
2056
J01AA07
ATC
tetracycline; systemic
2.0
8.3
104
575
XQ800
NOMESCO Finland
Prick test
2.4
8.0
55
239
R06AX22
ATC
ebastine; oral
1.9
8.0
116
673
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
3.7
7.8
24
66
D07CB01
ATC
triamcinolone and antibiotics; topical
4.4
7.7
19
44
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
3.7
7.6
24
67
E000003, ,
ATC
2.8
7.6
38
141
SPAT1249
SPAT
Treatment-related counselling outside office
1.6
7.5
257
1882
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.8
7.4
137
854
R06AX12
ATC
terfenadine; oral
2.9
7.4
35
126
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
7.4
157
1018
L28.1
ICD-10 Finland
Prurigo nodularis
8.5
7.3
15
18
L13.1
ICD-10 Finland
Subcorneal pustular dermatitis
+∞
7.3
7
*
SPAT1312
SPAT
General health counselling
1.6
7.3
205
1430
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.7
7.3
159
1039
R03DC03
ATC
montelukast; oral
1.8
7.2
115
688
D11AH01
ATC
tacrolimus; topical
8.0
7.1
15
19
UJD02
NOMESCO Finland
Gastroscopy
2.6
7.1
40
159
A10AA01, ,
ATC
3.3
6.9
26
82
L30.0
ICD-10 Finland
Nummular dermatitis
2.8
6.6
32
117
D11AX14
ATC
[U] tacrolimus
12.4
6.6
11
9
L03
ICPC
Low back symptom/complaint
1.6
6.5
196
1383
L28.0
ICD-10 Finland
Lichen simplex chronicus
7.5
6.4
14
19
B81
ICPC
Anaemia vit B12/folate deficiency
2.8
6.4
32
119
5790A
ICD-9 Finland
Intestinal malabsorption, Coeliac disease
14.5
6.4
10
7
J01DA01
ATC
[U] cefalexin
1.5
6.2
397
3284
B03BA03
ATC
hydroxocobalamin; parenteral
2.4
6.2
43
189
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.2
6.2
49
228
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.0
6.0
63
327

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
117
294
4.61
43.63
1.7
1.1
155.00
95.17
titre
—
19
6
297
1424
2.94
40.22
2.2
1.3
8.49
1.48
u/ml
4.14
120
374
81
257
3.45
21.26
1.3
1.2
—
—
—
0
0
224
1263
2.16
18.29
2.0
1.5
2.54
2.44
g/l
0.35
138
770
388
2844
1.86
13.64
3.4
3.1
133.43
128.54
ug/l
0.11
366
2672
102
483
2.31
12.35
1.6
1.2
—
—
—
0
0
153
854
2.02
12.18
1.4
1.2
—
—
—
0
0
197
1236
1.84
10.91
1.8
1.7
450.38
23121825.06
pmol/l
0.99
162
1038
406
3146
1.73
10.62
7.6
6.4
1.76
1.93
e9/l
2.10
364
2780
239
1600
1.77
10.60
2.3
2.3
2.54
2.97
mg/l
2.72
206
1386
359
2701
1.70
10.36
2.7
2.5
81.17
77.52
nmol/l
1.46
332
2431
397
3084
1.70
10.04
7.7
6.4
0.58
0.58
e9/l
0.03
351
2640
398
3096
1.70
9.99
7.7
6.4
0.04
0.04
e9/l
0.18
353
2653
165
1013
1.83
9.65
1.9
1.7
1213.93
1193.26
nmol/l
0.09
128
769
406
3194
1.68
9.59
7.9
6.6
0.21
0.19
e9/l
1.92
366
2791
164
1014
1.82
9.34
2.4
2.6
14.32
12.95
umol/l
1.46
152
945
43
153
2.93
9.29
1.3
1.1
54.01
5.99
eliau/ml
—
10
19
346
2676
1.60
8.23
5.3
5.1
36.15
35.79
g/l
0.63
325
2522
529
4555
1.75
8.10
5.1
4.3
14.83
14.76
pmol/l
0.27
498
4174
137
836
1.80
8.05
1.4
1.3
626.25
510.59
titre
0.24
32
187
355
2775
1.59
7.98
7.1
6.4
1.21
1.21
mmol/l
0.24
330
2550
276
2037
1.60
7.89
7.0
6.2
—
—
—
0
0
149
938
1.76
7.86
2.3
2.6
2.31
2.31
g/l
0.02
135
875
385
3086
1.58
7.63
7.9
7.2
1.21
1.21
mmol/l
0.10
330
2664
524
4531
1.70
7.54
8.6
8.4
75.42
78.73
u/l
1.43
498
4297
357
2840
1.55
7.11
7.5
6.6
9.33
8.92
%
2.09
340
2666
254
1876
1.57
7.04
5.0
4.2
7.40
7.40
ph
0.68
199
1324
356
2834
1.54
7.04
7.4
6.5
3.15
2.90
%
1.14
340
2659
416
3432
1.55
6.96
9.8
9.9
3.92
4.08
e9/l
0.92
366
3009
355
2832
1.54
6.90
7.5
6.6
0.73
0.69
%
0.71
340
2650
89
497
1.91
6.88
3.3
2.8
11.19
10.77
g/l
0.32
82
458
343
2720
1.53
6.83
2.3
2.1
93.80
95.74
pmol/l
0.34
184
1411
136
866
1.71
6.81
2.4
2.7
23.96
22.93
%
0.35
122
814
359
2898
1.51
6.42
7.5
6.6
27.81
27.67
%
0.09
344
2757
195
1379
1.58
6.42
6.3
5.1
—
—
—
0
0
155
1053
1.61
5.99
1.3
1.3
6.81
10.97
u/ml
0.48
65
398
25
85
3.02
5.90
1.6
1.1
10.39
1.51
eliau/ml
1.39
13
39
164
1137
1.58
5.81
1.4
1.3
29.19
33.51
iu/ml
0.24
51
353
239
1805
1.50
5.72
1.8
1.7
20.43
20.48
nmol/l
0.02
209
1534
85
498
1.81
5.64
4.3
2.9
67.64
66.61
g/l
0.65
80
465
74
416
1.87
5.60
4.3
2.4
—
—
—
0
0
349
2853
1.46
5.55
7.3
6.5
56.52
57.32
%
0.66
340
2728
613
5696
1.84
5.00
19.8
16.2
22.38
24.08
mg/l
0.66
514
4687
122
815
1.61
5.00
5.7
6.1
1.02
1.04
mmol/l
0.45
117
759
341
2825
1.42
4.77
16.1
13.5
1.25
1.24
inr
0.24
290
2351
49
254
2.00
4.72
2.4
2.1
8.49
8.16
iu/ml
0.02
12
66
265
2102
1.43
4.72
2.9
3.6
2.35
2.36
mmol/l
0.64
246
1919
583
5390
1.60
4.26
6.6
5.3
1.92
1.91
mu/l
0.08
552
4981
18
63
2.91
4.09
1.4
1.3
—
—
—
0
0
76
475
1.68
4.04
4.7
3.9
—
—
—
0
0
36
179
2.07
3.91
1.4
1.3
8.57
2.72
u/ml
—
9
21
36
180
2.06
3.86
1.5
1.3
2.41
11.10
u/ml
—
10
32
37
187
2.04
3.85
1.4
1.3
118.06
3.25
u/ml
—
5
11
440
3889
1.38
3.78
3.9
3.4
45.50
48.42
u/l
0.35
415
3678
227
1809
1.38
3.75
5.1
4.1
0.00
0.01
estimate
0.96
80
626
110
769
1.51
3.66
2.5
3.1
4.58
5.61
e9/l
0.41
98
672
618
5837
1.71
3.66
23.0
19.2
139.58
139.69
mmol/l
0.50
607
5726
194
1513
1.40
3.63
3.0
2.8
349.21
343.97
umol/l
0.29
168
1346
112
790
1.50
3.57
2.0
2.4
111.02
123.95
ug/g
0.22
86
632
372
3228
1.34
3.46
6.1
6.6
12.46
11.38
umol/l
0.81
346
3085
37
196
1.94
3.41
2.4
1.6
0.20
0.24
g/l
1.71
37
188
403
3543
1.34
3.40
6.0
5.0
6.77
6.66
mmol/l
0.44
386
3369
617
5843
1.66
3.38
23.4
19.3
3.98
3.97
mmol/l
0.03
604
5725
38
204
1.91
3.37
2.3
1.5
1.14
1.19
g/l
0.57
38
195
436
3883
1.35
3.35
5.5
4.8
6292.38
782.26
e6/l
—
8
68
10
23
4.40
3.32
1.2
2.1
39.51
41.55
g/l
—
10
23
632
6028
1.78
3.30
26.0
21.2
77.25
77.57
umol/l
0.09
625
5961
102
718
1.50
3.29
3.7
2.8
2.12
1.83
%
1.05
95
652
231
1882
1.35
3.23
2.5
2.2
152.38
272.68
u/l
1.53
220
1789
27
130
2.12
3.22
1.4
1.3
41.00
16.37
e6/l
0.30
19
97
137
1025
1.42
3.22
1.7
1.9
—
—
—
0
0
12
34
3.57
3.21
1.3
1.1
—
—
—
0
0
29
144
2.06
3.20
1.5
1.2
17.98
43.96
u/ml
—
5
16
13
40
3.29
3.15
1.3
1.1
—
—
—
0
0
236
1941
1.33
3.07
3.1
2.6
81.34
63.29
u/l
0.52
220
1810
16
62
2.62
3.06
4.3
2.4
—
—
—
0
0
48
287
1.72
3.04
1.6
1.9
1.41
1.46
g/l
0.13
38
260
50
304
1.70
2.99
1.3
1.3
—
—
—
0
0
117
868
1.42
2.87
1.7
1.6
—
—
—
0
0
517
4774
1.36
2.82
24.2
20.2
13.64
13.64
%
0.02
509
4727
33
183
1.84
2.70
1.3
1.2
255.00
104.35
titre
—
8
23
243
2037
1.30
2.69
3.6
3.3
32.16
32.56
u/l
0.05
231
1928
22
106
2.11
2.65
1.1
1.1
—
—
—
0
0
22
107
2.09
2.60
1.7
1.7
0.91
0.80
g/l
0.22
17
89
72
497
1.50
2.57
2.5
2.5
5.95
7.03
ug/l
0.31
63
451
70
481
1.51
2.55
4.6
3.9
1.24
1.23
mmol/l
1.28
62
409
307
2668
1.28
2.53
14.1
11.5
0.00
0.00
e9/l
0.12
253
2193
194
1589
1.31
2.52
3.5
3.2
—
0.00
estimate
—
0
6
78
551
1.47
2.49
4.2
2.8
75.89
70.02
e9/l
0.65
64
411
93
681
1.42
2.46
1.9
1.7
—
—
—
0
0
10
32
3.16
2.44
1.9
1.3
20.36
24.99
umol/l
—
10
27
23
117
2.00
2.43
1.2
1.4
—
—
—
0
0
251
2137
1.28
2.41
3.4
3.3
7.28
7.61
mmol/l
0.63
214
1818
238
2014
1.28
2.40
3.5
3.4
48.42
50.98
mg/l
0.07
156
1294
638
6159
1.67
2.38
31.1
24.9
243.90
248.76
e9/l
1.11
622
6053
13
52
2.53
2.37
1.5
1.3
6542.00
125826.65
e6/l
—
5
40
90
660
1.42
2.37
1.6
1.6
—
—
—
0
0
74
523
1.47
2.37
4.3
5.0
0.10
0.13
%
—
10
147
638
6160
1.67
2.36
31.0
24.8
91.67
91.22
fl
1.77
630
6100
26
140
1.89
2.35
2.6
1.5
—
—
—
0
0
638
6162
1.66
2.33
30.9
24.7
30.50
30.36
pg
1.32
630
6100
638
6162
1.66
2.33
31.4
25.2
47.11
40.26
%
0.48
630
6096
638
6162
1.66
2.33
31.0
24.8
4.40
4.47
e12/l
3.27
621
6040
73
516
1.47
2.33
6.6
7.7
10.43
9.94
mmol/l
0.22
68
496
76
542
1.45
2.32
4.6
5.3
0.20
0.15
%
—
10
144
638
6163
1.66
2.32
31.1
24.9
6.47
6.72
e9/l
2.92
620
6040
9
28
3.24
2.31
2.2
1.5
—
—
—
0
0
273
2358
1.27
2.31
5.1
3.9
45.73
77.32
ng/l
0.53
188
1703
638
6165
1.65
2.29
31.3
25.0
133.18
134.76
g/l
2.15
630
6103
94
700
1.40
2.27
2.4
2.8
11.30
7.79
umol/l
0.93
79
615
82
601
1.41
2.17
2.5
2.4
0.21
0.21
g/l
0.20
77
560
21
108
1.97
2.17
6.0
4.5
3.22
2.47
mmol/l
0.69
16
74
295
2585
1.25
2.17
4.0
3.6
6.43
6.21
ph
2.78
151
1461
363
3256
1.25
2.17
4.8
4.0
0.00
0.49
estimate
0.52
85
639
111
858
1.35
2.14
2.2
2.1
—
—
—
0
0
29
168
1.76
2.11
1.9
1.6
—
—
—
0
0
76
553
1.42
2.10
4.2
4.8
0.45
0.94
%
1.24
11
178
175
1448
1.28
2.07
4.9
4.1
1.02
1.02
kg/l
1.13
109
974
34
209
1.66
2.02
1.7
1.6
—
—
—
0
0
358
3223
1.24
2.01
4.8
4.0
14.01
5.12
estimate
0.27
89
684
20
105
1.93
1.97
1.1
1.1
1.04
1.93
u/ml
0.55
12
60
19
98
1.97
1.97
1.7
1.7
—
—
—
0
0
27
157
1.75
1.95
1.2
1.2
—
—
—
0
0
34
211
1.64
1.95
1.8
1.6
—
—
—
0
0
5
11
4.57
1.94
4.4
2.6
—
—
—
0
0
32
196
1.66
1.93
1.8
1.6
—
—
—
0
0
34
213
1.63
1.89
1.8
1.6
—
—
—
0
0
12
52
2.33
1.88
1.2
1.5
—
—
—
0
0
199
1692
1.25
1.86
3.6
3.3
0.76
0.38
e6/l
0.36
150
1251
145
1190
1.28
1.82
4.8
4.0
263.49
311.57
ng/l
0.16
105
940
19
101
1.91
1.82
1.1
1.0
—
—
—
0
0
71
525
1.39
1.81
4.0
4.8
1.20
0.58
%
—
10
162
13
60
2.19
1.78
1.1
1.1
—
—
—
0
0
65
475
1.41
1.78
4.0
4.0
115.19
84.69
ng/l
0.76
56
421
619
5984
1.42
1.74
14.8
12.4
27.28
25.96
u/l
0.64
600
5828
21
118
1.80
1.72
1.5
1.4
—
—
—
0
0
236
2062
1.22
1.69
4.2
4.1
6.95
9.21
mg/mmol
0.60
148
1277
70
523
1.38
1.69
1.6
1.8
—
—
—
0
0
33
212
1.59
1.68
1.8
1.6
—
—
—
0
0
280
2491
1.21
1.67
2.0
2.0
1.28
1.34
mmol/l
0.61
242
2089
165
1390
1.25
1.66
3.6
2.7
5.50
5.97
e6/l
0.15
152
1284
17
90
1.91
1.66
1.0
1.0
6.84
4.75
u/ml
—
9
45
11
49
2.27
1.64
5.0
3.0
502.18
966.86
mg
0.95
11
49
218
1896
1.22
1.63
3.8
3.1
—
—
—
0
0
194
1669
1.23
1.61
5.7
4.5
—
—
—
0
0
16
84
1.93
1.61
1.1
1.0
1.90
0.95
u/ml
—
9
35
15
77
1.97
1.60
1.4
2.3
17.27
4.82
umol/l
—
10
57
209
1817
1.22
1.56
5.2
6.4
—
—
—
0
0
350
3195
1.20
1.56
4.8
4.0
0.00
0.00
estimate
-0.00
85
671
61
453
1.38
1.55
5.7
3.1
133.57
181.52
ng/l
0.64
56
420
20
117
1.73
1.46
3.3
3.2
8.89
8.42
pmol/l
0.11
20
117
13
66
1.99
1.44
1.0
1.1
14.32
6.13
u/ml
—
5
23
586
5649
1.29
1.41
5.7
5.2
4.47
4.62
mmol/l
3.45
550
5291
15
81
1.87
1.41
1.0
1.0
3.72
0.85
u/ml
—
8
39
565
5424
1.26
1.40
6.8
6.5
39.28
39.37
mmol/mol
0.09
530
5101
28
182
1.56
1.39
1.3
1.3
—
—
—
0
0
20
119
1.70
1.39
1.3
1.3
204.35
262.48
u/ml
0.50
13
63
56
419
1.37
1.38
1.2
1.2
92.20
138.29
u/ml
0.49
26
163
576
5546
1.27
1.36
5.8
5.2
5.94
5.95
mmol/l
0.02
538
5114
270
2432
1.18
1.35
5.0
3.9
0.03
0.02
estimate
0.05
73
559
18
105
1.73
1.34
1.1
1.1
—
—
—
0
0
18
105
1.73
1.34
1.1
1.1
—
—
—
0
0
13
68
1.93
1.34
3.9
2.5
0.45
1.30
g/24h
—
7
42
12
61
1.98
1.33
1.2
1.1
—
—
—
0
0
96
780
1.27
1.33
1.6
1.4
—
—
—
0
0
23
145
1.61
1.30
1.8
1.8
—
—
—
0
0
43
311
1.41
1.30
2.2
2.3
—
—
—
0
0
5
18
2.79
1.28
1.4
1.4
—
—
—
0
0
5
18
2.79
1.28
1.0
2.2
1.92
4.82
mmol/l
—
5
13
15
84
1.80
1.28
1.3
1.2
—
—
—
0
0
138
1176
1.22
1.25
3.4
3.0
518.07
531.58
mosm/kgh2o
0.33
123
1044
123
1036
1.23
1.25
2.4
3.3
0.82
0.82
mmol/l
0.03
118
985
6
25
2.41
1.24
1.5
1.5
135.50
148.34
nmol/l
—
6
25
88
714
1.27
1.24
8.6
8.0
7.43
7.42
ph
0.91
61
425
9
45
2.01
1.23
1.6
1.3
—
—
—
0
0
27
180
1.52
1.22
1.1
1.4
196.44
249.32
miu/ml
0.54
16
88
10
49
2.06
1.22
3.0
1.8
1028.70
1101.00
e6/l
—
10
41
222
1981
1.18
1.22
3.9
3.4
27.88
82.82
e6/l
0.99
175
1536
24
156
1.56
1.21
1.8
1.8
3.82
4.58
iu/l
—
10
58
146
1261
1.20
1.16
2.8
2.9
2.44
2.45
mmol/l
1.03
134
1141
13
72
1.82
1.15
1.4
1.3
—
—
nmol/l
—
0
0
39
284
1.40
1.15
1.3
1.6
0.24
0.34
mg/l
0.53
20
121
37
500
0.72
1.11
1.4
1.4
—
—
—
0
0
591
5737
1.24
1.09
6.4
5.9
2.60
2.68
mmol/l
1.51
550
5350
580
5621
1.23
1.07
5.6
5.1
1.48
1.47
mmol/l
0.28
539
5231
28
196
1.45
1.04
1.6
1.4
273.49
293.39
ug/g
0.15
14
123
5
22
2.28
1.03
2.6
1.9
—
—
—
0
0
46
352
1.33
1.02
3.9
3.5
4.45
4.59
pmol/l
0.57
39
315
85
705
1.24
1.01
8.8
8.0
1.81
1.02
mmol/l
1.57
70
590
204
1834
1.16
1.00
4.8
5.4
1.77
2.47
ug/l
1.83
185
1656
556
5376
1.20
0.99
4.8
4.3
1.16
1.28
mmol/l
5.66
516
4968
302
2795
1.15
0.99
2.9
2.8
—
—
estimate
—
0
0
9
49
1.85
0.99
1.6
1.1
94.44
104.35
pmol/l
—
9
49
19
124
1.55
0.97
5.4
3.8
—
—
—
0
0
0
31
0.00
0.96
0.0
1.5
—
—
—
0
0
206
1861
1.15
0.95
3.4
3.2
1112.95
1176.78
ng/l
0.15
183
1603
9
51
1.77
0.95
1.0
1.1
—
0.11
—
0
6
11
62
1.79
0.94
1.5
1.8
—
—
—
0
0
31
226
1.39
0.94
1.5
1.6
6.70
10.30
u/ml
—
5
40
25
175
1.45
0.94
1.2
1.1
—
—
—
0
0
6
27
2.23
0.93
1.5
3.8
451.17
664.41
u/ml
—
6
27
23
159
1.46
0.92
1.1
1.1
—
—
—
0
0
18
118
1.54
0.91
1.2
1.9
5.58
4.92
mmol/24h
0.45
18
103
11
63
1.76
0.90
2.4
2.6
—
—
—
0
0
5
102
0.49
0.90
1.8
1.6
—
—
—
0
0
12
71
1.70
0.89
1.3
1.2
—
—
—
0
0
35
264
1.34
0.88
1.3
1.6
—
11.75
—
0
8
23
161
1.44
0.87
4.0
2.9
1.31
2.01
index
0.21
13
91
34
445
0.75
0.86
1.7
1.8
3.32
3.46
mmol/l
0.31
26
328
13
80
1.64
0.85
3.3
1.9
32.31
32.89
pg
0.21
13
80
245
2258
1.13
0.83
4.4
4.1
90.63
94.49
e6/l
0.05
185
1608
25
180
1.40
0.83
2.5
2.1
5202.66
4429.15
u/l
0.06
11
69
12
73
1.66
0.82
1.7
1.5
29.91
32.51
g/l
0.31
12
63
6
32
1.88
0.82
1.3
1.4
122.23
170.24
mmol/24h
—
6
32
67
560
1.22
0.78
2.3
2.5
34.00
33.42
u/l
0.05
58
466
5
100
0.50
0.78
1.8
1.5
—
—
—
0
0
492
4746
1.14
0.76
26.3
21.0
332.40
332.14
g/l
0.27
487
4725
76
646
1.20
0.75
1.5
1.6
—
—
—
0
0
16
231
0.69
0.74
2.6
2.8
—
—
—
0
0
12
184
0.65
0.74
1.1
1.1
0.91
0.89
g/l
0.13
12
184
7
38
1.85
0.73
3.7
1.9
320.86
182.16
e6/l
—
7
32
11
68
1.63
0.72
1.3
1.1
—
—
—
0
0
28
212
1.33
0.71
1.0
1.1
—
—
—
0
0
63
530
1.21
0.70
1.4
1.5
—
—
—
0
0
9
58
1.56
0.70
1.1
1.2
0.99
1.33
nmol/l
—
9
53
9
58
1.56
0.70
1.8
1.4
—
—
—
0
0
5
27
1.86
0.68
1.2
1.1
—
—
—
0
0
5
27
1.86
0.68
1.2
1.1
—
—
—
0
0
5
27
1.86
0.68
1.2
1.1
—
—
—
0
0
5
28
1.79
0.66
1.6
1.0
1486.80
1354.36
miu/ml
—
5
28
117
1043
1.15
0.66
2.9
3.0
0.93
0.93
e6/l
0.00
64
548
10
62
1.62
0.65
3.7
2.2
13.72
13.30
%
—
10
62
12
177
0.67
0.64
1.1
1.1
1.48
1.57
g/l
1.22
12
177
107
954
1.14
0.61
1.7
2.1
29.47
29.39
s
0.05
101
928
49
409
1.21
0.60
3.5
3.9
7.42
7.42
ph
0.01
43
343
51
428
1.21
0.60
1.3
1.4
—
—
—
0
0
250
2347
1.10
0.59
2.1
2.2
—
—
—
0
0
21
159
1.33
0.56
1.6
1.6
12680.13
12058.83
e6/l
0.03
15
112
6
38
1.58
0.54
4.2
1.8
260.67
462.25
e6/l
—
6
28
11
74
1.49
0.53
1.3
1.2
—
—
—
0
0
152
1398
1.11
0.53
1.9
1.8
0.88
1.26
mg/l
1.82
113
1096
187
1739
1.10
0.53
4.4
3.4
0.01
0.05
estimate
0.35
69
542
15
108
1.40
0.53
1.7
1.5
—
—
—
0
0
9
65
1.39
0.50
1.4
1.3
5.50
6.40
mmol/l
—
9
60
7
108
0.64
0.49
1.3
1.3
—
—
—
0
0
81
722
1.14
0.48
1.3
1.3
—
—
—
0
0
13
93
1.41
0.48
2.5
2.3
—
—
—
0
0
7
46
1.53
0.48
1.3
1.8
46.16
38.59
%
—
7
46
14
102
1.38
0.47
1.1
1.2
3.71
7.91
u/ml
—
7
46
42
493
0.84
0.47
2.3
2.4
6.52
6.11
ph
1.83
28
333
12
85
1.42
0.47
2.5
3.1
—
—
—
0
0
27
219
1.24
0.45
1.3
1.3
—
—
—
0
0
19
148
1.29
0.44
2.2
2.4
78.80
86.45
ug/min
—
10
84
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
5
31
1.62
0.43
1.0
1.1
1.08
1.07
ratio
—
5
26
66
586
1.14
0.43
2.5
2.1
0.00
0.00
estimate
-0.00
15
124
8
57
1.41
0.42
1.7
2.6
—
—
—
0
0
8
58
1.38
0.41
1.8
1.3
—
—
—
0
0
8
59
1.36
0.41
1.5
1.6
—
—
—
0
0
0
17
0.00
0.40
0.0
2.6
—
—
—
0
0
8
60
1.34
0.40
1.3
1.2
—
—
—
0
0
10
71
1.41
0.39
1.1
1.5
40.31
26.43
ng/l
—
10
71
33
280
1.19
0.38
2.0
1.9
—
—
—
0
0
5
37
1.35
0.37
7.0
1.5
—
—
—
0
0
23
189
1.22
0.36
8.3
3.5
2.87
3.20
ratio
0.11
14
105
16
126
1.28
0.35
1.6
4.1
26.68
299.68
u/ml
0.81
16
119
54
598
0.89
0.30
4.7
3.5
1.82
1.94
mmol/l
0.07
46
508
22
261
0.84
0.30
3.2
3.3
761.04
1890.12
u/ml
0.54
22
221
162
1701
0.94
0.28
1.5
1.4
—
—
—
0
0
12
151
0.79
0.28
5.6
4.5
—
—
—
0
0
61
557
1.10
0.28
4.0
3.9
7.30
7.35
ph
0.51
42
394
46
509
0.90
0.26
8.8
8.3
—
—
—
0
0
9
72
1.25
0.25
2.0
2.2
—
—
—
0
0
9
73
1.24
0.25
1.4
1.2
—
—
—
0
0
5
39
1.28
0.23
1.0
1.0
—
—
—
0
0
5
40
1.25
0.22
1.2
1.2
—
—
—
0
0
24
210
1.15
0.22
5.4
3.4
230.25
335.77
mg/l
0.48
12
88
0
11
0.00
0.21
0.0
4.8
—
6.96
—
0
11
0
11
0.00
0.21
0.0
1.0
—
0.02
—
0
11
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
58
625
0.92
0.21
4.9
3.6
7.37
7.38
ph
1.08
35
377
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.4
—
6140.33
—
0
12
24
272
0.88
0.21
2.1
1.7
—
—
—
0
0
0
13
0.00
0.21
0.0
3.2
—
50.00
—
0
8
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
10
80
1.25
0.20
2.1
1.4
—
—
—
0
0
10
80
1.25
0.20
2.1
1.4
—
—
—
0
0
10
80
1.25
0.20
2.1
1.4
—
—
—
0
0
10
80
1.25
0.20
2.1
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
44.16
—
0
14
6
49
1.23
0.20
1.2
1.3
—
—
—
0
0
56
601
0.93
0.19
1.5
1.5
—
—
—
0
0
218
2243
0.96
0.18
3.8
3.2
—
—
—
0
0
25
223
1.13
0.18
1.4
1.6
1060.04
964.31
mu/l
0.18
17
196
7
60
1.17
0.18
1.0
1.2
—
—
—
0
0
13
110
1.19
0.17
1.0
1.4
—
—
—
0
0
9
83
1.09
0.14
1.1
1.2
—
—
—
0
0
17
150
1.14
0.14
1.5
1.4
—
—
—
0
0
28
256
1.10
0.14
1.4
1.3
24.09
27.99
iu/l
0.23
22
213
10
84
1.19
0.14
1.2
1.2
—
—
—
0
0
11
128
0.86
0.13
1.4
1.6
49.31
59.49
ug/l
0.47
11
110
13
113
1.15
0.13
2.2
3.2
0.78
0.84
nmol/l
—
8
88
12
105
1.15
0.11
2.0
1.8
—
—
—
0
0
10
115
0.87
0.10
1.2
1.2
—
—
—
0
0
12
135
0.89
0.10
1.1
1.9
—
—
—
0
0
146
1429
1.03
0.09
2.7
2.5
—
—
—
0
0
15
136
1.11
0.08
2.2
1.9
215.67
206.95
pmol/l
0.16
15
128
6
57
1.05
0.08
1.0
1.2
—
—
—
0
0
7
65
1.08
0.08
1.6
1.2
—
—
—
0
0
29
274
1.06
0.07
2.7
2.0
3.18
2.54
ug/l
0.09
24
250
79
768
1.03
0.07
1.2
1.3
—
—
—
0
0
7
81
0.86
0.07
1.1
1.9
—
—
—
0
0
20
214
0.93
0.07
4.2
4.6
24.24
24.88
mmol/l
0.51
20
204
191
1937
0.98
0.06
2.7
2.5
—
—
—
0
0
38
364
1.05
0.06
6.6
8.9
24.22
24.51
mmol/l
0.24
38
359
10
111
0.90
0.06
1.1
1.6
—
—
—
0
0
108
1101
0.98
0.06
3.3
3.1
0.63
0.78
ug/l
0.94
75
712
11
121
0.91
0.06
1.3
1.7
1.16
0.92
nmol/l
0.59
11
102
53
546
0.97
0.05
6.4
6.9
1.35
1.30
mmol/l
0.19
53
536
55
561
0.98
0.03
1.5
1.4
—
—
—
0
0
30
291
1.03
0.02
1.1
1.1
—
—
—
0
0
65
641
1.02
0.02
3.9
4.4
2.61
29.96
ug/l
1.45
58
543
214
2129
1.01
0.02
4.4
3.6
—
0.86
—
0
7
33
322
1.03
0.02
2.5
2.3
0.00
0.00
estimate
—
9
104
13
137
0.95
0.01
1.1
1.2
—
—
—
0
0
19
183
1.04
0.01
13.0
9.9
—
—
—
0
0
21
206
1.02
0.00
5.8
4.1
1.49
1.34
mmol/l
0.33
21
200
41
405
1.01
0.00
1.1
1.2
—
—
—
0
0
18
181
0.99
0.00
1.8
1.9
50.61
41.95
nmol/l
0.72
18
173
29
289
1.00
0.00
4.0
4.1
—
—
—
0
0
97
969
1.00
0.00
3.0
3.2
3.38
2.60
e6/l
0.23
44
469
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
64.00
—
0
8
5
52
0.96
0.00
3.2
1.8
12.82
10.51
%
—
5
52
0
7
0.00
0.00
0.0
1.0
—
0.03
—
0
7
0
5
0.00
-0.00
0.0
3.0
—
203.20
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
0.44
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
9.17
—
0
6

Mortality – FinRegistry

↥

Association

Association between endpoint L12_DERMATHERP and mortality.

Females

Parameter HR [95% CI] p-value
L12_DERMATHERP 0.983 [0.85, 1.14] 0.828
Birth year 0.994 [0.99, 1.0] 0.152

During the follow-up period (1.1.1998 — 31.12.2019), 253 out of 1738 females with L12_DERMATHERP died.

Males

Parameter HR [95% CI] p-value
L12_DERMATHERP 0.935 [0.82, 1.07] 0.33
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 281 out of 1496 males with L12_DERMATHERP died.

Mortality risk

Mortality risk for people of age

years, who have L12_DERMATHERP.

N-year risk Females Males
1 0.093% 0.172%
5 0.593% 1.034%
10 1.418% 2.787%
15 2.79% 5.294%
20 4.949% 8.632%

Relationships between endpoints

↥

Index endpoint: L12_DERMATHERP – Dermatitis herpetiformis

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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