vesiculobullous skin disease: Skin diseases characterized by local or general distributions of vesicles and bullae (i.e. blisters). Both vesicles and bullae are fluid-filled lesions, distinguished by size (vesicles being less than 5–10 mm and bullae being larger than 5–10 mm). Vesiculobullous diseases are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. In the case of vesiculobullous diseases which are also immune disorders, the term immunobullous is sometimes used. (From Scientific American Medicine, 1990, and Wikipedia)
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2397 |
4. Check minimum number of eventsNone |
2397 |
5. Include endpoints |
2574 |
6. Filter based on genotype QC (FinnGen only) |
2327 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF2
Bullous disorders
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17606 | 9615 | 7867 |
| Only index persons | 14671 | 8199 | 6472 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.25 | 0.28 | 0.22 |
| Only index persons | 0.28 | 0.30 | 0.25 |
| Median age at first event (years) | |||
| Whole population | 66.48 | 67.70 | 64.95 |
| Only index persons | 64.83 | 65.56 | 63.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2327 | 1237 | 1090 |
| Unadjusted period prevalence (%) | 0.47 | 0.44 | 0.50 |
| Median age at first event (years) | 63.48 | 59.30 | 68.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2381
- Matched controls
- 23810
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D07AD01
ATC
clobetasol; topical
5.8
307.7
929
2382
K90.0
ICD-10 Finland
Coeliac disease
15.4
307.7
369
280
J04BA02
ATC
dapsone; oral
206.7
307.7
322
18
L13.0
ICD-10 Finland
Dermatitis herpetiformis
7078.4
307.7
559
*
L12.0
ICD-10 Finland
Bullous pemphigoid
3601.0
307.7
848
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
9.7
307.7
901
1401
L13.9
ICD-10 Finland
Bullous disorder, unspecified
172.3
307.7
365
25
L30.9
ICD-10 Finland
Dermatitis, unspecified
4.4
260.0
957
3147
L12.9
ICD-10 Finland
Pemphigoid, unspecified
466.0
256.5
252
6
D07AC01
ATC
betamethasone; topical
4.0
240.6
1393
6217
TQW80
NOMESCO Finland
Local dermatologic skincare
8.7
169.0
223
278
E0000UV, ,
ATC
3.2
167.8
1389
7230
L13.8
ICD-10 Finland
Other specified bullous disorders
81.1
161.4
86
11
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
3.7
145.4
569
1862
H02AB06
ATC
prednisolone; systemic
3.0
144.3
1522
8802
L04AX01
ATC
azathioprine; systemic
6.6
138.1
237
395
69399
ICD-8 Finland
Dermatitis herpetiformis
+∞
134.7
128
*
L12.8
ICD-10 Finland
Other pemphigoid
+∞
129.4
123
*
L12
ICD-10 Finland
Pemphigoid
63.6
122.8
68
11
D07AC13
ATC
mometasone; topical
2.8
119.5
949
4606
D07AB08
ATC
desonide; topical
3.4
102.6
437
1484
L04AX03
ATC
methotrexate; systemic
3.5
99.3
383
1220
D07AB02
ATC
hydrocortisone butyrate; topical
2.5
96.6
923
4797
XQ848
NOMESCO Finland
Dermatological photography
5.5
91.6
186
362
E000001, ,
ATC
2.7
89.2
647
2930
L10.9
ICD-10 Finland
Pemphigus, unspecified
+∞
83.8
80
*
L12.1
ICD-10 Finland
Cicatricial pemphigoid
+∞
82.8
79
*
L10.0
ICD-10 Finland
Pemphigus vulgaris
405.7
79.4
79
*
135
Kela drug reimbursment
Pemphigus
+∞
76.5
73
*
L11.1
ICD-10 Finland
Transient acantholytic dermatosis [Grover]
373.5
73.1
73
*
ECA20
NOMESCO Finland
Biopsy of gingiva
9.2
70.8
87
98
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
69.9
1051
6401
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.9
61.2
329
1257
D07BC01
ATC
betamethasone and antiseptics; topical
2.6
58.8
393
1677
R06AE07
ATC
cetirizine; oral
2.0
58.3
1105
7188
L29.9
ICD-10 Finland
Pruritus, unspecified
4.6
57.7
140
316
L30.3
ICD-10 Finland
Infective dermatitis
4.3
57.0
154
378
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
53.1
854
5202
D09AB01
ATC
zinc bandage without supplements; topical
5.3
48.8
101
199
QCA99
NOMESCO Finland
Other local destruction of skin of upper limb
17.5
46.3
38
22
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.3
44.8
175
553
D02AX
ATC
Other emollients and protectives
4.3
44.7
120
293
L10.2
ICD-10 Finland
Pemphigus foliaceus
+∞
40.7
39
*
L12.2
ICD-10 Finland
Chronic bullous disease of childhood
+∞
40.7
39
*
J01DB01
ATC
cefalexin; oral
2.1
40.6
1972
16581
S29
ICPC
Skin symptom/complaint other
2.0
40.2
580
3346
S97
ICPC
Chronic ulcer skin
2.6
39.1
238
961
L29.8
ICD-10 Finland
Other pruritus
5.7
39.0
73
131
A46
ICD-10 Finland
Erysipelas
2.1
38.9
454
2426
EKA10
NOMESCO Finland
iopsy of buccal mucosa
4.5
38.5
96
221
E000002, ,
ATC
2.4
38.5
302
1374
R06AX27
ATC
desloratadine; oral
1.9
38.3
652
3967
L04AA06
ATC
mycophenolic acid; systemic
5.4
38.0
76
145
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.2
37.7
155
505
A02BC02
ATC
pantoprazole; systemic
1.8
37.2
1685
13596
D02AE01
ATC
carbamide; topical
2.7
35.9
202
784
L10.8
ICD-10 Finland
Other pemphigus
+∞
35.5
34
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
35.3
413
2201
R06AE09
ATC
levocetirizine; oral
2.1
34.7
355
1798
D07AA02
ATC
hydrocortisone; topical
2.1
34.3
367
1890
J01FF01
ATC
clindamycin; systemic
1.8
34.1
688
4385
D05BB02
ATC
acitretin; oral
4.2
34.0
92
226
L20.0
ICD-10 Finland
Besnier prurigo
2.7
33.5
186
716
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
3.6
33.4
114
330
L28.1
ICD-10 Finland
Prurigo nodularis
7.1
33.1
50
72
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
32.9
389
2077
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
5.7
32.3
60
107
L30.0
ICD-10 Finland
Nummular dermatitis
3.1
31.8
141
480
S18
ICPC
Laceration/cut
1.7
31.8
1191
8946
6940A
ICD-9 Finland
Bullous dermatoses, Dermatitis herpetiformis
+∞
31.3
30
*
S99
ICPC
Skin disease other
3.9
31.2
95
254
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
30.7
1242
9482
A10AB05
ATC
insulin aspart; parenteral
2.3
30.6
239
1081
D07CC01
ATC
betamethasone and antibiotics; topical
2.1
30.6
337
1751
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.8
29.4
583
3671
E000007, ,
ATC
2.8
29.4
156
586
XQ802
NOMESCO Finland
Epicutan test
3.2
28.1
114
368
S02
ICPC
Pruritus
3.0
27.8
126
434
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.6
27.6
169
683
H02AB09
ATC
hydrocortisone; systemic
3.8
27.1
83
223
E000003, ,
ATC
2.9
27.0
129
458
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.9
26.8
382
2167
L30.8
ICD-10 Finland
Other specified dermatitis
3.5
26.7
94
278
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.3
26.6
225
1052
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.0
26.4
122
425
L10.4
ICD-10 Finland
Pemphigus erythematosus
+∞
26.1
25
*
J01MA02
ATC
ciprofloxacin; systemic
1.6
26.0
964
7107
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
3.3
25.7
100
315
A10AE04
ATC
insulin glargine; parenteral
2.0
24.9
278
1447
D07XC01
ATC
betamethasone; topical
2.0
24.6
312
1698
A10BH05
ATC
linagliptin; oral
2.4
23.9
174
762
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
3.4
23.9
87
263
C03CA01
ATC
furosemide; systemic
1.6
23.6
887
6517
XQ800
NOMESCO Finland
Prick test
2.4
22.6
169
748
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.9
22.3
312
1753
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
22.0
643
4437
K13.78
ICD-10 Finland
Other change in the oral mucosa
3.3
21.2
79
242
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.7
21.2
118
454
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
21.1
474
3058
ZY010
NOMESCO Finland
Hospital outpatient
2.6
21.1
127
509
E000006, ,
ATC
2.2
21.0
182
857
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
3.6
20.4
68
194
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.6
20.4
540
3629
R60.0
ICD-10 Finland
Localized oedema
1.8
20.2
345
2058
L04AD01
ATC
ciclosporin; systemic
4.1
20.0
55
137
L01.1
ICD-10 Finland
Impetiginization of other dermatoses
7.6
20.0
28
37
A10AC01
ATC
insulin (human); parenteral
2.1
19.7
210
1072
SBA00
NOMESCO Finland
Microbiological examinations
3.2
19.4
79
256
H02AB07
ATC
prednisone; oral
1.8
19.4
342
2058
SAA03
NOMESCO Finland
Extended examination of mouth
1.5
19.0
832
6248
J01CF05
ATC
flucloxacillin; systemic
2.1
18.8
188
936
L12.3
ICD-10 Finland
Acquired epidermolysis bullosa
+∞
18.8
18
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.6
18.6
477
3170
SPAT1263
SPAT
Sampling
1.5
18.5
952
7378
N02BE01
ATC
paracetamol; systemic, rectal
1.8
18.4
2080
18980
S21
ICPC
Skin texture symptom/complaint
1.7
18.4
381
2397
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.2
18.3
169
817
A28
ICPC
Limited function/disability NOS
1.6
18.2
525
3589
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.6
18.2
601
4239
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
18.2
832
6293
L08.8
ICD-10 Finland
Other specified local infections of skin and subcutaneous tissue
2.7
18.1
95
355
K12.10
ICD-10 Finland
Stomatitis NOS
6.7
17.9
28
42
H13.3*L12.9
ICD-10 Finland
Ocular pemphigoid
+∞
17.7
17
*
J01AA07
ATC
tetracycline; systemic
1.8
17.6
304
1815
L89
ICD-10 Finland
Decubitus ulcer and pressure area
3.1
17.4
74
246
L50.9
ICD-10 Finland
Urticaria, unspecified
2.7
17.3
96
369
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.8
17.3
309
1864
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.4
17.0
118
505
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
3.3
17.0
64
198
S17
ICPC
Abrasion/scratch/blister
3.0
16.8
76
262
L11.0
ICD-10 Finland
Acquired keratosis follicularis
+∞
16.7
16
*
L10.1
ICD-10 Finland
Pemphigus vegetans
+∞
16.7
16
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.0
16.6
197
1043
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
16.6
689
5086
RD210, ,
NOMESCO Finland
3.7
16.6
53
147
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
7.3
16.5
24
33
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
16.3
891
6940
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.5
16.2
696
5169
H02AB04
ATC
methylprednisolone; systemic
1.7
16.2
331
2071
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.0
16.1
169
857
L01.0
ICD-10 Finland
Impetigo [any organism] [any site]
3.6
16.0
52
146
L13.1
ICD-10 Finland
Subcorneal pustular dermatitis
+∞
15.6
15
*
SPAT1153
SPAT
Removal of sutures
1.5
15.6
734
5546
D05AX52
ATC
calcipotriol, combinations; topical
2.3
15.5
124
566
C07AB07
ATC
bisoprolol; oral
1.4
15.4
1210
10030
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
15.3
423
2850
Z3231
NOMESCO Finland
Registered nurse
1.5
15.3
628
4614
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
2.6
15.1
90
359
R06AX13
ATC
loratadine; oral
1.7
15.1
294
1814
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
2.8
15.1
75
273
J01DA01
ATC
[U] cefalexin
1.4
15.0
1360
11540
N02AX02
ATC
tramadol; systemic, rectal
1.4
15.0
972
7777
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.4
14.9
1001
8057
SPAT1229
SPAT
Assessment of need for aid
1.9
14.9
209
1171
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.5
14.7
616
4536
B86
ICD-10 Finland
Scabies
3.1
14.6
61
201
R53
ICD-10 Finland
Malaise and fatigue
1.5
14.5
597
4379
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.7
14.5
299
1872
L51.19
ICD-10 Finland
Other bullous erythema multiforme
150.9
14.5
15
*
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.9
14.4
192
1058
R03AC02
ATC
salbutamol; inhalant
1.4
14.4
1189
9900
S76
ICPC
Skin infection other
2.1
14.2
142
708
SPAT1262
SPAT
Handing over of treatment supplies
1.6
14.1
415
2836
J45
ICD-10 Finland
Asthma
1.8
13.9
231
1362
103
Kela drug reimbursment
Diabetes, insulin-treated
1.5
13.9
658
4958
M05BA04
ATC
alendronic acid; oral
1.8
13.8
237
1409
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
3.1
13.8
57
187
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.4
13.7
767
5956
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.7
13.6
242
1454
69400
ICD-8 Finland
Pemphigus, Vulgaris, vegetans, foliaceus
+∞
13.6
13
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
13.6
504
3617
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.6
13.5
348
2301
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
6.1
13.4
23
38
H04.10
ICD-10 Finland
Dry eye syndrome
1.7
13.4
266
1648
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.7
13.4
250
1523
R06.0
ICD-10 Finland
Dyspnoea
1.4
13.3
659
4997
L73.8
ICD-10 Finland
Other specified follicular disorders
4.6
13.3
31
68
J05AB01
ATC
aciclovir; systemic
1.5
13.2
480
3425
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
13.2
391
2670
K11.70
ICD-10 Finland
Hypoptyalism
5.5
13.1
25
46
L51.9
ICD-10 Finland
Erythema multiforme, unspecified
11.0
13.0
24
22
T90
ICPC
Diabetes non-insulin dependent
1.5
13.0
586
4364
R03BA01
ATC
beclometasone; inhalant
1.6
12.9
312
2031
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.7
12.9
282
1790
H04AA01
ATC
glucagon; nasal, parenteral
3.2
12.9
51
163
WX110
NOMESCO Finland
Infiltration anesthesia
1.4
12.9
1528
13397
L04AA01
ATC
[U] ciclosporin
3.8
12.9
38
100
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
12.9
769
6023
L08.0
ICD-10 Finland
Pyoderma
4.5
12.8
31
70
AA1AD
NOMESCO Finland
CT of head and brain
1.4
12.8
720
5583
D11AH01
ATC
tacrolimus; topical
5.0
12.6
27
55
SPAT1301
SPAT
No procedures
1.4
12.5
712
5524
L11.9
ICD-10 Finland
Acantholytic disorder, unspecified
+∞
12.5
12
*
M79.6
ICD-10 Finland
Pain in limb
1.4
12.5
954
7777
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.4
12.4
87
375
J05AB11
ATC
valaciclovir; oral
1.6
12.4
323
2140
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
3.3
12.3
46
142
Z2221
NOMESCO Finland
Medical doctor
1.4
12.3
587
4410
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
3.7
12.2
38
104
SPAT1254
SPAT
Administration of medicine
1.5
12.2
368
2523
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
2.7
12.1
64
241
A10AA01, ,
ATC
2.8
12.1
61
224
L21.8
ICD-10 Finland
Other seborrhoeic dermatitis
3.6
12.0
39
110
P01BA02
ATC
hydroxychloroquine; oral
1.8
12.0
177
1007
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
2.4
11.9
78
326
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.5
11.8
412
2911
J02AC01
ATC
fluconazole; systemic
1.4
11.7
752
5941
UJF32
NOMESCO Finland
Coloscopy
1.4
11.7
595
4518
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
11.7
932
7629
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.4
11.5
612
4679
B35.3
ICD-10 Finland
Tinea pedis
2.1
11.5
107
519
A10AB01
ATC
insulin (human); parenteral
2.4
11.5
78
332
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
1.6
11.5
283
1850
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
11.4
830
6689
L29
ICD-10 Finland
Pruritus
3.4
11.4
40
119
XQ845
NOMESCO Finland
Dermatoscopy
2.7
11.4
60
226
L43.9
ICD-10 Finland
Lichen planus, unspecified
2.8
11.4
55
198
D07XB05
ATC
dexamethasone; topical
2.5
11.3
69
279
K90.9
ICD-10 Finland
Intestinal malabsorption, unspecified
10.6
11.3
21
20
H3603, E103,
ICD-10 Finland
4.9
11.2
24
49
Z71.8
ICD-10 Finland
Other specified counselling
1.4
11.2
705
5546
D07AC14
ATC
methylprednisolone aceponate; topical
2.1
11.2
108
532
A10AE05
ATC
insulin detemir; parenteral
2.0
11.2
128
671
R03DC03
ATC
montelukast; oral
1.5
11.1
335
2295
L43.8
ICD-10 Finland
Other lichen planus
2.9
10.9
51
180
I50.9
ICD-10 Finland
Heart failure, unspecified
1.5
10.9
398
2835
L17
ICPC
Foot/toe symptom/complaint
1.4
10.8
674
5288
J01AA04
ATC
lymecycline; systemic
1.6
10.7
246
1579
I10
ICD-10 Finland
Essential (primary) hypertension
1.3
10.7
1457
12857
L03.1
ICD-10 Finland
Cellulitis of other parts of limb
2.4
10.7
72
306
D64.9
ICD-10 Finland
Anaemia, unspecified
1.6
10.6
289
1931
R03BA02
ATC
budesonide; inhalant
1.5
10.6
376
2659
R01AD08
ATC
fluticasone; nasal
1.4
10.6
546
4146
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
5.0
10.5
22
44
D06AX01
ATC
fusidic acid; topical
1.7
10.5
203
1247
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
1.8
10.5
171
1002
A04
ICPC
Weakness/tiredness general
1.5
10.5
375
2658
NHQ40
NOMESCO Finland
Amputation of toe
2.9
10.5
48
168
Z43.5
ICD-10 Finland
Attention to cystostomy
4.2
10.4
27
65
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
10.3
397
2857
D01AE15
ATC
terbinafine; topical
1.8
10.2
162
941
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
1.9
10.2
121
641
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
4.6
10.2
24
53
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.5
10.2
375
2673
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.5
10.1
375
2675
A98
ICPC
Health maint/preventive medicine
1.6
10.1
2172
20590
B00.19
ICD-10 Finland
Other vesicular dermatitis caused by the herper simplex virus
5.3
10.1
20
38
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
2.4
10.1
69
295
T89
ICPC
Diabetes insulin dependent
2.2
10.1
88
417
TPH04
NOMESCO Finland
Cathetrisation of vein
1.4
10.1
497
3740
EBA15
NOMESCO Finland
Extraction of multiple teeth
2.1
10.1
96
471
E87.5
ICD-10 Finland
Hyperkalaemia
2.5
10.0
59
236
N03AX16
ATC
[U] pregabalin
1.4
9.9
492
3705
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
1.7
9.9
164
966
A02BC03
ATC
lansoprazole; oral
1.4
9.9
631
4957
L43.1
ICD-10 Finland
Bullous lichen planus
16.8
9.9
15
9
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.6
9.7
272
1828
A10AE06
ATC
insulin degludec; parenteral
2.2
9.7
79
364
L10
ICD-10 Finland
Pemphigus
55.2
9.6
11
*
A08
ICPC
Swelling
1.8
9.6
150
869
B03BA03
ATC
hydroxocobalamin; parenteral
1.8
9.6
143
817
L28
ICPC
Limited function/disability (L)
1.4
9.6
476
3585
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.6
9.5
250
1656
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.7
9.4
190
1180
69300, ,
ICD-8 Finland
+∞
9.4
9
*
D99
ICPC
Disease digestive system other
3.5
9.3
31
89
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
1.7
9.3
155
914
J01AA02
ATC
doxycycline; systemic
1.3
9.3
1697
15452
L50.3
ICD-10 Finland
Dermatographic urticaria
2.9
9.3
42
146
J33.0
ICD-10 Finland
Polyp of nasal cavity
2.3
9.2
68
301
OAB50, ,
SPAT
1.7
9.2
183
1133
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
2.1
9.2
88
433
L13
ICD-10 Finland
Other bullous disorders
13.7
9.2
15
11
A29
ICPC
General symptom/complaint other
1.5
9.2
317
2229
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.5
9.1
356
2562
R06AX22
ATC
ebastine; oral
1.5
9.1
318
2239
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
1.6
9.1
250
1673
WX002
NOMESCO Finland
Sedation and analgesia
1.4
9.1
423
3145
G63.2*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy
3.1
9.1
37
121
SPAT1310
SPAT
Counselling related to known health issue
1.3
9.1
664
5317
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.6
9.0
193
1217
D01AC02
ATC
miconazole; topical
1.7
9.0
174
1069
L30.4
ICD-10 Finland
Erythema intertrigo
2.9
8.9
40
139
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
2.8
8.9
42
150
WW200
NOMESCO Finland
Immunization
2.4
8.9
60
256
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
12.6
8.9
15
12
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
2.4
8.8
59
250
N05BB01
ATC
hydroxyzine; systemic
1.8
8.8
131
747
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.3
8.8
879
7350
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.5
8.8
297
2078
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.4
8.8
383
2814
L28.0
ICD-10 Finland
Lichen simplex chronicus
3.4
8.8
30
88
WX892
NOMESCO Finland
Monitored bed care
1.7
8.8
175
1085
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
2.1
8.8
83
407
B01AF02
ATC
apixaban; oral
1.5
8.8
338
2428
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
2.1
8.7
77
367
A10BA02
ATC
metformin; oral
1.3
8.7
656
5268
SPAT1285
SPAT
Provision of consultation response
1.8
8.6
117
649
N30.0
ICD-10 Finland
Acute cystitis
1.4
8.6
373
2737
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
8.6
1061
9121
R50.9
ICD-10 Finland
Fever, unspecified
1.5
8.5
330
2370
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
2.6
8.5
47
182
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.0
8.5
89
453
R03BA05
ATC
fluticasone; inhalant
1.4
8.5
365
2675
R11
ICD-10 Finland
Nausea and vomiting
1.6
8.5
195
1253
K12.18
ICD-10 Finland
Other forms of stomatitis
4.2
8.5
22
53
A41.9
ICD-10 Finland
Sepsis, unspecified
2.0
8.4
90
461
ZX120
NOMESCO Finland
Intravenous
1.6
8.4
199
1286
R01AD09
ATC
mometasone; nasal
1.3
8.4
865
7249
R01BA52
ATC
pseudoephedrine, combinations; oral
1.4
8.4
564
4448
XCK10
NOMESCO Finland
Photography of fundus of eye
1.6
8.4
216
1425
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.5
8.4
289
2030
K29.4
ICD-10 Finland
Chronic atrophic gastritis
2.4
8.4
57
244
Z2446
NOMESCO Finland
Social worker
1.7
8.3
138
813
B37.08
ICD-10 Finland
Other candidal stomatitis
3.5
8.2
27
77
JN3AD
NOMESCO Finland
Abdominal CT examination
1.5
8.2
284
1995
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
8.2
1451
13028
E86
ICD-10 Finland
Volume depletion
2.1
8.2
71
337
QDA10
NOMESCO Finland
Incision of skin of lower limb
3.7
8.2
25
68
N18.8
ICD-10 Finland
Other chronic renal failure
2.2
8.2
63
285
177
Kela drug reimbursment
Insulin glargine 300 U / ml
2.5
8.2
48
192
Z3226
NOMESCO Finland
Physiotherapist
1.4
8.1
384
2860
K59.09
ICD-10 Finland
Constipation, unspecified
1.6
8.1
167
1044
RS222, ,
NOMESCO Finland
3.1
8.1
32
103
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
2.2
8.1
67
312
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
1.7
8.1
155
951
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
2.3
8.1
57
248
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
2.3
8.1
57
248
WZC00, ,
SPAT
1.5
8.1
304
2172
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.5
8.1
262
1818
J01MA12
ATC
levofloxacin; systemic
1.4
8.0
410
3096
J45.1
ICD-10 Finland
Nonallergic asthma
1.7
8.0
153
939
K12.00
ICD-10 Finland
Recurrent oral aphthae
2.9
8.0
35
120
L23.9
ICD-10 Finland
Allergic contact dermatitis, unspecified cause
3.5
8.0
26
74
D11AX14
ATC
[U] tacrolimus
7.2
8.0
18
25
A02BC05
ATC
esomeprazole; systemic
1.3
8.0
838
7034
C08CA01
ATC
amlodipine; oral
1.3
8.0
897
7596
ZXA05
NOMESCO Finland
Left side
1.3
7.9
531
4182
SAA02
NOMESCO Finland
Basic examination of mouth
1.3
7.9
1317
11705
M81.4
ICD-10 Finland
Drug-induced osteoporosis
4.4
7.9
19
43
S01
ICPC
Pain/tenderness of skin
1.8
7.9
105
580
K13.74
ICD-10 Finland
Lichen rubs planus in the mouth
2.7
7.9
42
160
A10AA02, ,
ATC
2.1
7.9
75
369
SPAT1167
SPAT
Insertion of urinary catheter
2.0
7.9
85
438
N02AJ06
ATC
codeine and paracetamol; systemic
1.3
7.9
863
7280
SPAT1312
SPAT
General health counselling
1.3
7.9
637
5159
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.4
7.8
417
3167
TQW99
NOMESCO Finland
Other minor procedure on skin
1.7
7.8
126
737
Z49.0
ICD-10 Finland
Preparatory care for dialysis
3.3
7.8
28
85
J46
ICD-10 Finland
Status asthmaticus
2.2
7.8
66
311
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
1.9
7.7
93
497
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
1.7
7.7
152
940
H36.01
ICD-10 Finland
Diabetic maculopathy
2.9
7.7
34
117
N18.0
ICD-10 Finland
End-stage renal disease
3.2
7.7
30
96
L28.2
ICD-10 Finland
Other prurigo
5.9
7.7
20
34
A07AA02
ATC
nystatin; oral
1.7
7.6
137
826
N17.9
ICD-10 Finland
Acute renal failure, unspecified
1.8
7.6
108
608
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
2.1
7.6
66
313
N02AA05
ATC
oxycodone; systemic
1.4
7.6
443
3412
XF600
NOMESCO Finland
Bloodpressure measurement
1.7
7.6
141
858
Q82.80
ICD-10 Finland
Benign familial pemphigus [Hailey-Hailey]
18.4
7.6
11
6
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
2.0
7.6
83
430
J01DA09
ATC
[U] cefadroxil
1.3
7.6
511
4028
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
1.7
7.6
128
760
Z94.0
ICD-10 Finland
Kidney transplant status
3.4
7.5
26
77
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
3.3
7.5
27
82
R03AC12
ATC
salmeterol; inhalant
1.8
7.5
107
604
J01FA01
ATC
erythromycin; systemic
1.5
7.5
238
1643
L03.9
ICD-10 Finland
Cellulitis, unspecified
2.5
7.5
47
194
A10BH02
ATC
vildagliptin; oral
2.4
7.5
51
219
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
3.7
7.5
23
63
ZXA10
NOMESCO Finland
Bilateral
1.4
7.4
404
3078
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.5
7.4
220
1499
S87
ICPC
Dermatitis/atopic eczema
2.3
7.4
53
233
JN4AD
NOMESCO Finland
Body CT examination
1.5
7.4
254
1784
R02
ICPC
Shortness of breath/dyspnoea
1.4
7.4
305
2218
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
3.8
7.4
22
59
SPAT1099
SPAT
Measurement of blood pressure with Doppler ultrasound device
2.0
7.3
77
393
A10AB04
ATC
insulin lispro; parenteral
2.2
7.3
61
285
107
Kela drug reimbursment
Pernicious anaemia
2.4
7.3
49
209
EBA10
NOMESCO Finland
Operative extraction of tooth
1.5
7.3
216
1470
L10.3
ICD-10 Finland
Brazilian pemphigus [fogo selvagem]
+∞
7.3
7
*
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
2.6
7.3
41
161
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
1.9
7.3
92
501
SPAT1298
SPAT
Other function in accordance with nutritional therapy nomenclature
3.7
7.2
22
60
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.3
7.2
525
4183
E000004, ,
ATC
2.5
7.2
42
168
L51.8
ICD-10 Finland
Other erythema multiforme
30.1
7.1
9
*
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
2.3
7.1
52
230
NHQ30
NOMESCO Finland
Amputation of foot, transmetatarsal
4.1
7.1
19
47
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.1
7.1
66
323
R4180
NOMESCO Finland
Podiatric therapy
2.8
7.1
34
123
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
5.6
7.1
19
34
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
2.5
7.0
41
164
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
2.1
7.0
60
284
SPAT1172
SPAT
Guidance concerning hydration
2.1
7.0
60
284
SPAT1260
SPAT
Consultation of another employee
1.4
7.0
363
2744
K08.3
ICD-10 Finland
Retained dental root
1.6
7.0
169
1100
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
3.9
7.0
20
52
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.4
6.9
272
1959
R07.4
ICD-10 Finland
Chest pain, unspecified
1.3
6.9
614
5023
H3601, E103,
ICD-10 Finland
4.0
6.9
19
48
L50.0
ICD-10 Finland
Allergic urticaria
2.2
6.9
52
234
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
1.6
6.9
160
1032
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
3.1
6.9
27
87
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.4
6.9
274
1979
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.5
6.8
192
1292
K02.1
ICD-10 Finland
Caries of dentine
1.3
6.8
1139
10053
R60.9
ICD-10 Finland
Oedema, unspecified
1.7
6.8
127
774
J01EA01
ATC
trimethoprim; systemic
1.3
6.8
545
4392
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
2.7
6.8
35
131
L04AA13
ATC
[U] leflunomide
2.3
6.8
50
222
L23.3
ICD-10 Finland
Allergic contact dermatitis due to drugs in contact with skin
4.1
6.8
18
44
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.0
6.8
74
383
SPAT1216
SPAT
Assessment of functional ability
1.4
6.8
365
2773
R49.08
ICD-10 Finland
Other specified dysphonia
2.3
6.8
49
216
C09BA02
ATC
enalapril and diuretics; systemic
1.5
6.8
186
1245
A06AD11
ATC
lactulose; oral
1.4
6.8
358
2712
A02BC01
ATC
omeprazole; systemic
1.3
6.8
573
4653
ZXE00
NOMESCO Finland
One hour or less
1.3
6.8
790
6684
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.3
6.8
426
3317
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
2.6
6.8
38
149
D05AX02
ATC
calcipotriol; topical
1.9
6.8
78
412
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
1.7
6.8
125
761
127
Kela drug reimbursment
Transplant complication
2.8
6.7
32
115
H3600, E103,
ICD-10 Finland
3.4
6.7
23
68
N06AX11
ATC
mirtazapine; oral
1.3
6.7
699
5836
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
1.9
6.7
74
386
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.3
6.6
811
6901
H10.4
ICD-10 Finland
Chronic conjunctivitis
3.1
6.6
26
84
Z02.7
ICD-10 Finland
Issue of medical certificate
1.6
6.6
156
1012
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
4.2
6.5
17
41
R01AD05
ATC
budesonide; nasal
1.6
6.5
144
917
R01AD11
ATC
triamcinolone; nasal
1.6
6.5
158
1030
L03.0
ICD-10 Finland
Cellulitis of finger and toe
1.5
6.5
170
1127
ZZA00
NOMESCO Finland
Split skin graft
2.0
6.5
67
341
B01AB05
ATC
enoxaparin; parenteral
1.3
6.5
664
5525
C03DA01
ATC
spironolactone; oral
1.4
6.5
285
2095
XF400
NOMESCO Finland
ECG with 12 standard connections
1.4
6.4
346
2628
4047, ,
NOMESCO Finland
70.0
6.4
7
*
T36
ICD-10 Finland
Poisoning by systemic antibiotics
1.9
6.4
72
377
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.4
6.4
338
2559
D01BA02
ATC
terbinafine; oral
1.3
6.4
517
4171
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.3
6.4
600
4937
ZXD10
NOMESCO Finland
Scheduled procedure
1.3
6.4
774
6573
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.5
6.3
191
1305
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
1.6
6.3
146
940
R55
ICD-10 Finland
Syncope and collapse
1.4
6.3
250
1802
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
2.3
6.3
46
204
UDH02
NOMESCO Finland
Rhinopharyngoscopy
1.6
6.3
133
838
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
3.6
6.3
20
56
L23.0
ICD-10 Finland
Allergic contact dermatitis due to metals
3.2
6.3
24
76
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
3.9
6.3
18
47
3AC01, ,
NOMESCO Finland
3.0
6.2
26
87
Z49.1
ICD-10 Finland
Extracorporeal dialysis
2.6
6.2
33
126
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
1.8
6.2
96
557
A12AA04
ATC
calcium carbonate; oral
2.5
6.2
38
156
A11CC03
ATC
alfacalcidol; systemic
2.1
6.2
55
265
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.6
6.2
144
930
R03AC03
ATC
terbutaline; inhalant
1.4
6.2
261
1904
Z01.2
ICD-10 Finland
Dental examination
1.2
6.2
879
7595
N03AX12
ATC
[U] gabapentin; oral
1.4
6.2
325
2461
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.5
6.2
195
1347
ZXE10
NOMESCO Finland
More than one and less than three hours
1.3
6.1
737
6243
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
2.7
6.1
30
110
SPAT1211
SPAT
Application of soft bandage
1.5
6.1
182
1241
L70.0
ICD-10 Finland
Acne vulgaris
2.5
6.1
35
139
196
Kela drug reimbursment
Paricalcitol and cinacalcet
4.1
6.1
16
39
B81
ICPC
Anaemia vit B12/folate deficiency
1.8
6.1
89
508
D20
ICPC
Mouth/tongue/lip symptom/complaint
1.7
6.1
99
583
SPAT1325
SPAT
Vaccination
1.3
6.1
727
6155
SPAT1104
SPAT
Monitoring of emergency patient
1.6
6.1
137
878
G35
ICD-10 Finland
Multiple sclerosis
2.8
6.1
29
105
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
2.6
6.0
33
128
J01CA04
ATC
amoxicillin; systemic
1.3
6.0
1735
16176
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
1.9
6.0
67
350
A01AC01
ATC
triamcinolone; local oral
2.5
6.0
37
152
5790A
ICD-9 Finland
Intestinal malabsorption, Coeliac disease
10.0
6.0
11
11
R5110, ,
SPAT
1.5
6.0
196
1361
ZYC01
NOMESCO Finland
Remote contact by phone
1.7
6.0
116
715
WZC30
NOMESCO Finland
Teaching
1.4
6.0
332
2532
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
558
131
55.33
307.65
1.7
1.1
98.04
82.73
titre
0.18
51
11
729
145
72.02
307.65
2.7
1.2
31.64
14.00
u/ml
8.78
351
15
567
136
54.41
307.65
1.7
1.2
545.74
562.00
titre
—
148
5
80
22
37.59
129.02
1.1
1.0
—
—
—
0
0
1606
10668
2.55
98.03
10.2
6.1
0.62
0.60
e9/l
1.71
1453
9051
1607
10693
2.55
97.46
10.2
6.1
0.04
0.04
e9/l
1.23
1456
9074
1625
10892
2.55
96.62
10.2
6.2
1.78
1.89
e9/l
2.13
1484
9491
1631
11017
2.53
94.24
10.5
6.3
0.22
0.19
e9/l
7.81
1491
9519
1507
10079
2.35
84.93
10.4
6.4
25.67
26.75
%
3.32
1465
9523
841
4444
2.38
82.12
1.7
1.3
4.44
1.67
u/ml
3.06
267
1161
1476
9868
2.30
82.01
10.2
6.3
58.97
58.07
%
2.13
1444
9402
1690
12031
2.39
80.00
12.6
9.4
4.30
4.22
e9/l
0.75
1523
10382
339
1251
2.99
67.52
1.5
1.3
654.14
212.28
u/ml
5.44
324
1155
445
1972
2.55
61.83
2.7
2.2
359.10
382.25
nmol/l
1.62
419
1820
706
3944
2.12
56.24
1.8
1.5
2.52
2.54
g/l
0.07
446
2369
106
201
5.47
53.43
1.3
1.2
—
—
—
0
0
1374
9983
1.89
48.78
5.8
5.1
34.38
35.08
g/l
4.30
1291
9357
239
890
2.87
46.15
1.4
1.1
147.75
166.63
titre
0.08
20
19
950
6228
1.87
45.72
2.9
2.4
2.80
2.89
mg/l
0.48
841
5358
672
3998
1.95
43.00
3.3
2.7
12.35
12.38
umol/l
0.03
632
3723
1488
11331
1.84
42.90
8.6
7.4
1.21
1.21
mmol/l
1.05
1313
9765
411
2097
2.16
39.81
2.3
2.8
66.18
66.17
g/l
0.00
386
1919
1916
15983
2.02
39.77
10.3
8.4
81.22
81.27
u/l
0.01
1843
15135
1296
9643
1.75
38.60
3.9
3.1
144.02
132.74
ug/l
0.79
1218
8914
1346
10175
1.74
37.40
7.8
6.7
1.21
1.21
mmol/l
0.62
1254
9383
1823
15199
1.85
34.55
5.8
4.5
14.36
13.33
mm/h
2.04
1731
14149
1314
10020
1.69
33.95
2.5
2.2
94.92
94.71
pmol/l
0.05
736
5318
573
3466
1.86
33.61
3.3
2.7
21.57
22.10
%
0.42
536
3230
415
2258
2.01
33.38
3.4
2.6
77.01
68.72
e9/l
3.46
305
1684
203
821
2.61
33.15
1.8
1.7
6.51
7.44
iu/ml
0.20
45
192
604
3734
1.83
32.93
3.3
2.6
2.25
2.27
g/l
0.41
568
3444
1449
11413
1.69
32.48
6.6
6.6
12.46
12.00
umol/l
0.43
1375
10873
61
110
5.66
32.44
1.1
1.2
—
—
—
0
0
1214
9154
1.67
31.97
16.6
12.0
0.00
0.00
e9/l
0.73
1012
7433
955
6787
1.68
31.45
2.0
1.8
19.59
20.20
nmol/l
0.64
843
5734
136
459
3.08
31.12
1.3
1.2
1.47
5.07
u/ml
0.70
12
28
159
589
2.82
30.78
1.4
1.2
83.56
34.69
u/ml
0.67
12
28
185
741
2.62
30.77
1.2
1.2
2.25
0.72
u/ml
0.41
14
53
158
585
2.82
30.62
1.8
1.6
0.22
0.23
g/l
0.57
151
557
161
604
2.79
30.43
1.8
1.5
1.18
1.18
g/l
0.06
156
575
1250
9577
1.64
30.27
2.9
2.5
80.15
78.35
nmol/l
1.28
1139
8539
41
54
7.71
29.34
1.8
1.3
8.89
8.93
ug/l
0.02
41
54
152
567
2.80
29.03
1.4
1.2
4.98
8.49
u/ml
0.53
28
88
642
4174
1.74
28.89
2.0
1.8
1207.24
1164.06
nmol/l
0.49
494
3153
151
565
2.79
28.67
1.4
1.2
8.50
3.27
u/ml
0.84
21
48
473
2821
1.84
28.47
3.7
4.1
239.25
248.84
u/l
0.81
448
2662
1331
10532
1.60
26.86
18.0
18.0
1.32
1.32
inr
0.01
1129
8849
306
1612
2.03
26.56
3.1
2.8
10.55
10.73
g/l
0.28
286
1478
1550
12770
1.61
25.97
6.2
5.3
7.10
6.80
mmol/l
4.91
1490
12167
88
254
3.56
25.90
1.6
1.4
—
—
—
0
0
257
1289
2.11
25.41
1.8
1.9
1.25
1.42
g/l
0.69
243
1177
2152
19495
2.08
24.70
26.8
18.1
24.50
25.95
mg/l
1.45
1907
16398
1661
14005
1.62
24.43
6.3
5.1
6623.10
1487.88
e6/l
1.45
29
216
216
1033
2.20
24.08
1.9
2.5
7.24
7.44
g/l
1.15
205
942
215
1032
2.19
23.74
1.9
2.4
3.62
3.77
g/l
0.88
204
941
215
1033
2.19
23.68
1.9
2.5
4.17
4.20
g/l
0.22
204
943
204
968
2.21
23.17
1.9
2.5
2.88
2.98
g/l
0.72
193
877
116
431
2.78
22.32
1.4
1.2
29.17
54.70
u/ml
1.19
17
40
372
2236
1.79
21.30
2.5
2.2
0.21
0.20
g/l
0.42
351
2087
190
906
2.19
21.29
2.0
2.5
9.74
10.47
g/l
1.85
177
808
230
1193
2.03
20.66
1.8
1.8
1.51
1.50
g/l
0.08
197
1031
482
3140
1.67
20.59
7.1
5.8
1.06
1.04
mmol/l
0.64
455
2907
401
2488
1.74
20.51
2.4
2.8
10.03
8.58
umol/l
0.47
348
2205
361
2180
1.77
20.28
7.7
7.0
11.77
10.67
mmol/l
1.83
342
2093
603
4178
1.59
20.02
2.2
1.9
—
—
—
0
0
1763
15360
1.57
19.85
5.0
4.4
15.02
14.92
pmol/l
0.84
1642
13932
912
6941
1.51
19.73
2.6
2.2
198.11
224.87
u/l
0.41
866
6548
955
7340
1.50
19.69
3.6
3.3
1850.89
1576.93
ng/l
0.92
838
6402
160
743
2.24
19.12
2.0
2.4
0.00
0.00
g/l
0.50
141
656
668
4790
1.55
18.91
1.9
1.8
13020340.57
19747586.40
pmol/l
0.19
553
3955
1502
12708
1.49
18.83
4.1
3.4
57.05
52.11
u/l
1.07
1424
11831
1354
11222
1.48
18.82
5.0
4.2
0.00
0.14
estimate
0.54
267
2272
2170
20041
1.93
18.65
30.5
21.9
139.20
139.62
mmol/l
10.33
2142
19642
1345
11167
1.47
18.29
5.0
4.1
4.33
4.54
estimate
0.02
288
2435
2010
18205
1.67
17.86
6.4
5.5
2.02
1.97
mu/l
0.75
1888
16686
990
7771
1.47
17.84
3.4
3.4
2.34
2.35
mmol/l
1.50
906
7034
473
3168
1.62
17.83
2.1
1.8
—
—
—
0
0
115
477
2.48
17.77
1.2
1.1
38.09
6.03
eliau/ml
0.90
15
47
1326
11014
1.46
17.75
5.0
4.1
0.00
0.00
estimate
0.50
274
2367
149
693
2.23
17.74
2.0
2.5
0.00
0.00
g/l
-0.00
141
655
139
628
2.29
17.74
1.5
1.5
0.54
11.44
iu/ml
0.54
24
118
2168
20075
1.89
17.61
30.8
22.1
3.99
3.99
mmol/l
0.04
2136
19638
548
3811
1.57
17.58
3.1
3.1
0.81
0.82
mmol/l
0.70
515
3576
180
909
2.06
17.36
2.0
2.5
0.55
1.22
g/l
2.75
161
777
936
7298
1.47
17.31
4.5
3.5
146.73
80.92
e6/l
0.29
732
5636
968
7612
1.46
17.05
3.9
3.4
6.78
7.26
mmol/l
3.23
829
6369
882
6819
1.47
16.94
3.4
2.7
67.30
73.02
u/l
0.18
816
6292
157
763
2.13
16.75
1.9
2.4
0.03
0.02
g/l
0.09
143
689
367
2340
1.67
16.73
4.5
3.6
—
—
—
0
0
949
7464
1.45
16.55
4.6
4.2
12.98
9.18
mg/mmol
0.87
646
4669
822
6300
1.47
16.38
4.4
3.4
0.53
0.46
e6/l
0.21
619
4702
1022
8186
1.44
15.99
5.2
4.2
121.15
113.02
e6/l
0.12
752
5864
2200
20581
1.91
15.65
35.3
23.9
84.78
80.51
umol/l
4.15
2180
20319
438
2964
1.59
15.61
2.1
1.9
—
—
—
0
0
2016
18427
1.61
15.46
8.2
6.9
41.10
39.87
mmol/mol
6.32
1909
17069
1051
8513
1.42
15.20
5.0
4.2
91.48
70.71
ng/l
0.16
808
6394
619
4559
1.48
14.82
2.1
1.7
1.51
1.35
mg/l
0.35
488
3560
281
1735
1.70
14.35
1.8
1.6
—
—
—
0
0
2173
20332
1.79
14.29
18.7
12.7
25.54
25.22
u/l
0.31
2122
19698
858
6807
1.41
13.50
3.4
3.2
42.31
34.30
u/l
0.89
813
6423
1772
15916
1.44
13.21
32.7
22.4
13.95
13.77
%
5.97
1755
15695
2216
20925
1.85
13.16
40.8
27.4
247.31
246.36
e9/l
0.26
2180
20469
371
2506
1.57
13.16
4.4
3.6
5.89
5.83
kpa
0.66
360
2440
2216
20929
1.85
13.09
40.6
27.3
92.01
91.46
fl
6.41
2196
20669
44
127
3.51
13.06
1.9
2.1
—
—
—
0
0
2216
20931
1.85
13.06
40.7
27.4
4.33
4.42
e12/l
13.22
2178
20393
2216
20931
1.85
13.06
41.2
27.9
41.40
40.00
%
0.31
2194
20660
2216
20935
1.84
12.99
40.8
27.4
7.06
6.86
e9/l
3.86
2179
20396
60
210
2.91
12.99
1.1
1.1
76.60
46.06
u/ml
—
5
17
2216
20937
1.84
12.96
41.1
27.6
130.52
133.13
g/l
13.31
2195
20684
404
2804
1.53
12.65
6.6
7.6
5.12
5.08
kpa
0.27
385
2689
404
2805
1.53
12.63
6.6
7.6
12.08
11.98
kpa
0.13
386
2695
398
2782
1.52
12.01
6.6
7.5
0.74
0.95
mmol/l
0.42
325
2283
327
2192
1.57
11.93
5.7
7.3
1.44
1.38
mmol/l
0.53
320
2149
2030
18835
1.53
11.86
6.0
5.5
6.13
6.01
mmol/l
3.31
1900
17101
662
5117
1.41
11.77
3.7
2.7
6.23
5.47
e6/l
0.57
607
4668
231
1431
1.68
11.60
4.8
3.5
23.56
24.08
mmol/l
1.33
226
1414
716
5630
1.39
11.44
3.4
2.9
357.59
350.25
umol/l
0.91
621
4880
353
2435
1.53
11.29
4.5
3.6
1.45
1.86
mmol/l
1.12
315
2085
156
876
1.84
11.02
3.4
3.6
33.79
78.42
mg/l
1.72
130
756
156
878
1.83
10.94
3.4
3.6
66.89
55.50
mg/l
0.41
131
757
526
3951
1.43
10.88
3.6
3.1
1.30
1.22
e6/l
0.12
290
2138
60
232
2.63
10.82
1.3
1.1
6.90
1.87
eliau/ml
1.19
21
83
1282
11091
1.34
10.82
2.9
2.8
—
—
—
0
0
485
3596
1.44
10.76
1.4
1.3
26.88
35.26
iu/ml
1.12
151
1117
357
2496
1.51
10.69
6.7
7.9
95.68
95.45
%
0.33
345
2408
1999
18581
1.47
10.63
25.8
17.8
75.00
76.90
ml/min/173m2
3.31
1901
17308
309
2099
1.54
10.58
3.8
3.1
4.39
4.48
kpa
0.38
297
2041
120
630
1.95
10.43
3.7
3.6
2.36
1.65
index
0.32
56
321
691
5479
1.37
10.28
5.1
4.2
87.17
86.59
%
0.25
679
5360
154
884
1.79
10.14
2.5
2.2
467.53
730.06
ug/l
0.46
145
834
169
997
1.75
10.13
5.8
5.3
1.02
0.88
%
2.63
164
940
243
1577
1.60
10.13
4.3
4.0
5.22
5.16
kpa
0.48
233
1513
296
2028
1.52
9.71
2.4
2.5
5.87
6.84
ug/l
0.57
249
1771
87
423
2.10
9.37
7.6
5.5
621.38
767.40
iu/ml
0.10
13
60
170
1032
1.70
9.21
2.2
1.8
2.31
2.01
ug/l
0.15
148
899
344
2457
1.47
9.19
2.4
2.3
169.84
138.12
ug/g
0.73
274
1942
481
3656
1.40
9.12
3.7
3.3
2.83
2.32
e6/l
0.50
243
1829
2018
18923
1.44
9.00
5.6
5.3
4.40
4.51
mmol/l
4.64
1877
17491
2050
19285
1.45
8.92
6.3
6.1
2.52
2.60
mmol/l
4.13
1913
17751
48
184
2.64
8.86
2.1
2.4
11.15
10.97
umol/l
0.01
39
127
134
773
1.78
8.71
1.4
1.3
—
—
—
0
0
325
2320
1.46
8.69
7.2
8.3
118.14
120.31
g/l
1.10
320
2264
765
6292
1.32
8.59
5.3
4.2
0.00
0.00
estimate
1.54
249
2166
569
4484
1.35
8.56
5.3
4.2
179.18
385.67
ng/l
3.14
468
3718
200
1290
1.60
8.55
3.5
2.7
0.80
0.62
%
4.02
200
1282
135
789
1.75
8.40
3.4
3.4
3.29
3.18
ratio
0.03
73
461
1137
9879
1.29
8.39
3.1
2.9
—
—
estimate
—
0
0
444
3373
1.39
8.38
1.4
1.3
8.78
13.06
u/ml
0.88
170
1241
265
1840
1.50
8.13
4.6
3.9
118.98
93.20
ng/l
2.19
231
1580
457
3509
1.37
8.06
2.2
2.1
29.55
29.83
s
0.45
444
3405
29
89
3.29
7.93
1.2
1.1
1591.93
1583.70
miu/ml
0.01
29
89
92
486
1.93
7.92
1.5
1.4
—
—
—
0
0
81
414
1.99
7.68
1.4
1.4
—
—
—
0
0
1995
18789
1.38
7.61
5.5
5.2
1.44
1.45
mmol/l
0.41
1842
17233
53
230
2.33
7.58
1.7
1.6
60.73
60.96
%
0.01
40
138
216
1461
1.53
7.51
6.6
9.4
23.76
24.24
mmol/l
1.31
208
1430
699
5766
1.30
7.47
3.6
3.2
0.08
0.04
0.23
12
165
201
1345
1.54
7.34
4.0
3.9
1.67
1.93
mmol/l
0.39
139
993
581
4684
1.32
7.33
3.0
3.0
2.46
2.46
mmol/l
0.08
527
4220
56
253
2.24
7.31
1.4
1.6
46.17
28.74
ng/l
0.36
56
253
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
135
822
1.68
7.28
2.7
2.8
0.40
0.35
iu/ml
0.81
75
454
17
38
4.50
7.18
1.2
1.1
—
—
—
0
0
231
1602
1.49
7.13
1.9
1.7
—
—
—
0
0
99
559
1.80
6.97
1.3
1.3
—
—
—
0
0
1705
15786
1.28
6.75
35.2
23.7
330.58
331.54
g/l
4.05
1695
15682
187
1257
1.53
6.70
1.6
1.5
—
—
—
0
0
57
270
2.14
6.66
3.9
6.6
7.63
7.31
mmol/l
0.35
51
231
212
1476
1.48
6.43
7.6
6.6
24.79
24.44
mmol/l
0.70
206
1408
952
8273
1.25
6.42
5.2
4.2
0.02
0.37
estimate
0.73
235
1955
72
379
1.93
6.33
4.6
3.9
0.97
1.53
%
1.05
60
335
1909
17984
1.31
6.31
4.8
4.4
1.26
1.27
mmol/l
0.24
1746
16320
115
703
1.67
6.15
1.6
1.6
22.46
17.00
u/ml
0.21
21
142
192
1323
1.49
6.13
2.4
2.5
34.50
20.86
au/ml
—
8
116
599
4961
1.28
6.00
5.3
4.3
1.02
1.32
kg/l
0.50
410
3315
176
1197
1.51
5.99
1.2
1.3
29.32
53.54
au/ml
—
10
90
74
402
1.87
5.94
1.1
1.3
—
316.00
—
0
10
283
2113
1.39
5.85
3.0
2.4
39.87
38.12
u/l
0.11
241
1756
86
494
1.77
5.77
1.8
2.8
31.44
34.06
umol/l
0.59
75
436
67
365
1.86
5.36
1.3
1.2
242.26
253.41
u/ml
0.10
44
210
108
675
1.63
5.34
1.5
1.4
240.33
278.39
ug/g
0.96
56
405
64
346
1.87
5.25
1.8
1.4
170.94
157.16
au/ml
0.43
18
102
101
627
1.64
5.14
2.4
1.7
—
—
—
0
0
106
667
1.62
5.11
4.0
3.6
1.88
1.64
mg/l
1.81
98
601
93
567
1.67
5.08
1.6
1.7
16783.83
13519.97
e6/l
0.19
71
394
272
2070
1.35
4.99
1.8
1.8
1.60
1.51
%
0.94
223
1760
32
135
2.39
4.98
1.1
1.2
84.78
80.71
—
5
7
117
762
1.56
4.90
1.7
1.6
0.30
0.33
mg/l
0.26
63
336
73
421
1.76
4.88
1.6
1.4
—
—
—
0
0
52
270
1.95
4.84
1.3
1.3
278.74
276.84
mosm/kgh2o
0.22
39
201
97
606
1.63
4.83
1.3
1.6
—
—
—
0
0
13
25
5.22
4.76
8.2
13.2
5.60
5.16
mmol/l
0.15
13
25
226
1692
1.37
4.61
3.9
2.9
57.44
62.74
ml/min/173m2
1.38
109
753
239
1809
1.36
4.55
5.3
3.9
1.23
1.23
mmol/l
0.88
218
1543
37
174
2.14
4.50
1.1
1.1
—
—
—
0
0
49
256
1.93
4.50
6.1
3.8
58.28
57.90
%
0.04
41
220
29
124
2.36
4.41
1.9
2.2
247.83
228.58
e6/l
0.21
18
110
53
287
1.87
4.38
1.4
1.6
—
—
—
0
0
33
150
2.22
4.37
2.0
1.5
1.11
1.03
promille
0.12
26
117
365
2954
1.28
4.30
1.6
1.5
—
—
—
0
0
34
158
2.17
4.28
1.1
1.1
—
—
—
0
0
259
2005
1.33
4.25
4.2
3.1
184.72
222.50
ng/l
0.99
239
1846
92
591
1.58
4.14
1.7
1.4
—
—
—
0
0
35
167
2.11
4.13
1.1
1.1
—
—
—
0
0
35
167
2.11
4.13
1.1
1.1
—
—
—
0
0
88
560
1.59
4.12
1.2
1.2
—
—
—
0
0
626
5403
1.22
4.11
3.0
2.5
—
—
—
0
0
88
561
1.59
4.09
2.8
2.3
128.08
128.56
g/l
0.07
76
448
39
196
2.01
4.03
1.1
1.2
—
—
—
0
0
28
124
2.27
3.97
1.9
2.1
375.37
561.83
e6/l
1.18
16
101
34
164
2.09
3.92
1.1
1.1
—
—
—
0
0
26
112
2.34
3.92
1.9
2.4
687.08
1281.83
u/ml
1.47
26
112
86
556
1.57
3.79
1.2
1.2
—
—
—
0
0
36
180
2.02
3.79
1.2
1.2
103.36
107.26
pmol/l
0.22
36
180
241
1880
1.31
3.76
2.8
2.5
0.43
0.49
e6/l
0.23
229
1801
89
581
1.55
3.76
6.6
2.5
192.33
196.62
%
0.16
81
552
58
341
1.72
3.71
1.6
1.4
—
—
—
0
0
35
175
2.01
3.69
1.3
1.2
—
—
—
0
0
79
506
1.58
3.64
1.4
1.4
—
—
—
0
0
79
506
1.58
3.64
1.4
1.4
—
—
—
0
0
90
594
1.54
3.64
1.7
1.6
—
—
—
0
0
120
846
1.44
3.52
2.7
2.7
—
—
—
0
0
31
151
2.07
3.52
1.8
1.3
—
—
—
0
0
31
151
2.07
3.52
1.8
1.3
—
—
—
0
0
88
583
1.53
3.51
1.7
1.5
—
—
—
0
0
145
1059
1.39
3.49
2.2
2.2
0.00
0.83
estimate
0.51
35
306
93
625
1.51
3.47
3.5
2.5
3.53
3.63
g/l
0.25
82
591
61
373
1.65
3.40
1.2
1.3
—
—
—
0
0
656
5782
1.19
3.34
4.7
3.6
0.07
0.18
estimate
0.36
229
1850
129
931
1.41
3.34
2.2
2.0
—
—
—
0
0
78
509
1.55
3.34
2.6
2.3
137.05
110.80
ug/min
0.14
41
304
15
54
2.79
3.25
1.2
1.2
91.60
84.37
%
—
5
30
34
177
1.93
3.24
1.6
1.5
33.84
28.17
%
0.31
24
110
23
103
2.25
3.22
1.5
1.1
0.50
0.51
ratio
0.08
14
62
23
104
2.22
3.15
1.9
1.3
—
—
—
0
0
23
104
2.22
3.15
1.9
1.3
—
—
—
0
0
15
55
2.74
3.15
1.2
1.6
98.40
85.34
%
—
5
32
119
857
1.41
3.14
2.0
1.9
—
—
—
0
0
309
2547
1.24
3.12
10.4
7.6
—
—
—
0
0
53
322
1.66
3.06
4.5
6.3
11.73
12.35
mg/l
0.47
47
300
17
68
2.51
3.04
3.0
2.6
0.62
0.61
mmol/l
0.22
17
68
47
278
1.70
3.00
1.2
1.2
5.29
6.44
u/ml
0.17
24
128
117
851
1.39
2.93
4.7
4.3
24.64
24.82
mmol/l
0.28
110
785
9
22
4.10
2.88
1.4
1.1
—
—
—
0
0
31
165
1.89
2.81
1.2
1.1
221.43
152.50
titre
—
7
24
74
498
1.50
2.80
1.6
1.6
—
—
—
0
0
74
498
1.50
2.80
1.2
1.3
168.33
231.80
miu/ml
1.03
28
217
70
467
1.51
2.77
1.3
1.5
13067.77
749.17
e6/l
0.46
57
366
93
658
1.43
2.74
1.2
1.3
—
—
—
0
0
782
7092
1.15
2.68
5.3
5.9
3.55
3.80
ug/l
0.06
708
6351
25
127
1.98
2.60
2.8
2.7
42.21
38.98
%
0.41
14
71
91
649
1.42
2.59
1.6
1.7
—
—
—
0
0
89
633
1.42
2.57
3.4
2.3
99.82
91.34
%
2.68
82
614
37
215
1.73
2.56
1.4
1.3
12302.29
82223.97
e6/l
1.37
17
147
29
157
1.86
2.52
1.9
1.7
—
—
—
0
0
68
464
1.48
2.45
1.3
1.4
18.40
43.26
e6/l
0.55
50
345
46
288
1.61
2.43
1.2
1.2
3.95
4.03
u/ml
0.01
21
98
20
96
2.09
2.43
1.1
1.1
—
—
—
0
0
312
2647
1.21
2.41
1.6
1.4
—
—
—
0
0
59
394
1.51
2.37
1.8
1.6
—
—
—
0
0
43
268
1.62
2.32
1.1
1.1
—
—
—
0
0
73
512
1.44
2.30
1.3
1.3
—
—
—
0
0
23
119
1.94
2.30
2.3
2.1
74.57
98.56
ug/min
—
7
27
45
285
1.59
2.28
1.4
1.4
—
—
—
0
0
55
365
1.52
2.28
1.6
1.5
29.12
31.40
g/l
0.72
48
329
116
886
1.33
2.21
1.2
1.3
—
—
—
0
0
152
1205
1.28
2.20
3.3
3.5
4.23
4.47
pmol/l
2.54
130
1065
7
19
3.69
2.15
1.3
1.3
—
—
—
0
0
44
282
1.57
2.14
1.4
1.4
—
—
—
0
0
75
537
1.41
2.14
1.7
2.0
2.68
14.91
iu/l
0.59
24
215
197
1618
1.24
2.11
1.6
1.5
—
—
—
0
0
15
68
2.21
2.11
1.0
1.1
—
—
—
0
0
21
109
1.93
2.10
1.1
1.1
1.11
1.18
u/l
—
5
51
8
25
3.21
2.09
1.4
1.0
—
—
—
0
0
44
284
1.56
2.09
1.4
1.4
—
—
—
0
0
14
62
2.27
2.07
1.0
1.1
—
—
—
0
0
21
110
1.92
2.05
3.9
3.8
—
—
—
0
0
68
487
1.41
1.96
1.1
1.1
2.78
4.08
—
9
46
23
127
1.82
1.94
1.6
1.4
—
—
—
0
0
876
8142
1.12
1.93
2.1
1.9
1.30
1.32
mmol/l
0.37
754
6791
31
188
1.66
1.91
1.1
1.1
—
—
—
0
0
112
872
1.30
1.90
1.7
2.0
39.25
39.11
u/l
0.02
102
766
47
317
1.49
1.86
1.1
1.1
1.27
1.92
u/ml
0.56
30
171
22
123
1.80
1.80
1.4
1.4
1.09
1.08
nmol/l
0.03
17
85
79
590
1.35
1.80
3.9
3.4
0.84
0.82
nmol/l
0.17
65
479
68
498
1.38
1.75
1.6
1.5
—
—
—
0
0
34
514
0.66
1.67
1.3
1.2
0.87
0.89
g/l
0.15
34
514
6
19
3.16
1.66
2.2
1.6
—
—
—
0
0
38
252
1.52
1.65
1.3
1.3
273.06
315.31
pmol/l
0.37
31
217
34
220
1.55
1.65
3.8
3.6
10.44
11.23
index
0.53
18
119
5
14
3.58
1.61
1.2
1.0
—
—
—
0
0
22
128
1.73
1.60
1.2
1.1
—
—
—
0
0
40
272
1.48
1.56
1.3
1.4
—
—
—
0
0
17
93
1.83
1.51
1.1
2.9
100.33
71.58
mg/l
0.41
12
69
11
51
2.16
1.50
1.0
1.2
16.23
16.17
umol/l
0.02
11
43
22
131
1.69
1.49
1.2
1.4
—
—
—
0
0
22
131
1.69
1.49
1.2
1.4
—
—
—
0
0
12
58
2.07
1.49
1.6
1.8
60.83
566.67
nmol/24h
0.54
12
58
39
267
1.47
1.49
1.1
1.1
126.26
114.75
%
1.25
34
241
28
178
1.58
1.48
1.2
1.6
—
—
—
0
0
17
94
1.81
1.47
1.2
1.6
39.44
39.84
g/l
0.09
17
94
42
293
1.44
1.46
1.5
1.6
—
—
—
0
0
33
486
0.67
1.46
1.3
1.2
1.43
1.54
g/l
1.88
33
486
22
132
1.67
1.46
1.6
1.4
—
—
—
0
0
58
429
1.36
1.45
2.2
1.9
1.06
0.86
nmol/l
1.03
45
355
6
22
2.73
1.43
2.2
1.5
—
—
—
0
0
16
88
1.82
1.41
1.7
2.6
31.29
93.83
umol/l
—
7
53
24
149
1.62
1.41
1.6
1.4
—
—
—
0
0
18
104
1.74
1.37
1.0
1.1
—
—
—
0
0
39
273
1.44
1.35
1.3
1.4
—
—
—
0
0
61
461
1.33
1.35
2.2
2.2
3330.08
4762.89
u/l
0.23
21
194
44
316
1.40
1.33
1.1
1.1
11.30
18.63
au/ml
—
6
64
28
184
1.53
1.31
1.6
1.5
—
—
—
0
0
39
275
1.43
1.31
1.3
1.4
—
—
—
0
0
138
1157
1.20
1.30
4.5
3.6
1.02
1.02
ratio
0.11
128
1056
45
326
1.39
1.30
1.0
1.1
12.37
78.68
iu/ml
—
8
61
8
34
2.36
1.29
1.3
1.2
—
—
—
0
0
20
122
1.64
1.27
1.7
1.9
—
—
—
0
0
15
84
1.79
1.27
1.3
1.4
—
1164639.80
iu/ml
—
0
5
25
162
1.55
1.26
1.4
1.0
—
—
—
0
0
14
77
1.82
1.25
4.4
1.6
—
—
—
0
0
13
70
1.86
1.24
1.2
1.5
—
—
—
0
0
17
100
1.71
1.23
1.1
1.1
—
—
—
0
0
18
108
1.67
1.22
4.0
3.6
2.14
1.14
%
0.53
18
108
8
37
2.17
1.21
1.1
1.1
—
—
—
0
0
41
297
1.39
1.20
1.3
1.6
—
—
—
0
0
25
164
1.53
1.20
1.0
1.0
291.40
287.50
mg/l
0.09
25
147
67
524
1.29
1.19
1.7
1.6
332.44
292.10
mu/l
0.57
62
479
6
26
2.31
1.18
1.0
1.0
—
—
—
0
0
36
256
1.41
1.18
1.1
1.1
2.54
1.53
u/ml
0.41
22
135
25
165
1.52
1.17
3.0
2.3
757.29
638.47
ml
0.63
17
105
18
110
1.64
1.15
1.2
1.3
135.11
134.79
nmol/l
0.01
18
110
11
59
1.87
1.07
1.4
1.0
—
—
—
0
0
610
5720
1.09
1.06
4.5
4.9
23.38
21.95
%
1.49
288
2955
37
271
1.37
1.05
1.0
1.1
5.99
3.84
u/ml
0.29
21
139
29
204
1.43
1.03
1.0
1.1
18.59
5.46
u/ml
0.98
15
92
9
50
1.80
0.96
2.2
1.5
—
—
—
0
0
31
225
1.38
0.94
1.1
1.5
0.24
0.31
nmol/l
0.66
20
176
6
27
2.23
0.93
1.2
1.1
—
—
—
0
0
6
27
2.23
0.93
1.0
1.0
—
—
—
0
0
38
286
1.33
0.93
1.1
1.1
—
—
—
0
0
25
175
1.43
0.93
2.6
2.8
27.44
31.47
mg/l
0.25
18
133
27
192
1.41
0.92
1.9
1.5
—
—
—
0
0
27
192
1.41
0.92
1.9
1.5
—
—
—
0
0
27
192
1.41
0.92
1.9
1.5
—
—
—
0
0
6
28
2.15
0.91
1.0
1.6
54.17
46.07
umol/l
—
6
28
11
63
1.75
0.90
1.5
1.4
—
—
—
0
0
58
467
1.25
0.87
1.4
1.5
—
—
—
0
0
266
2422
1.11
0.87
3.9
4.2
5.42
22.31
ug/l
2.93
215
2009
6
30
2.00
0.87
1.0
1.2
—
—
—
0
0
43
334
1.29
0.86
1.7
1.4
1160.06
4146.26
e6/l
0.60
31
235
27
195
1.39
0.86
2.3
1.7
3.16
4.48
mg/l
2.27
27
190
14
88
1.59
0.84
1.6
2.3
1021.25
760.38
e6/l
—
8
68
8
46
1.74
0.82
1.0
1.6
—
—
—
0
0
8
48
1.67
0.78
2.4
1.2
—
—
—
0
0
6
34
1.77
0.76
26.2
6.8
6.23
5.13
kpa
—
6
34
138
1556
0.88
0.76
1.9
2.0
3.44
3.45
ratio
0.03
113
1226
5
25
2.00
0.72
1.2
1.1
—
—
—
0
0
9
57
1.58
0.71
1.2
1.1
—
—
—
0
0
16
109
1.47
0.71
1.3
1.4
—
—
—
0
0
20
143
1.40
0.70
2.0
1.7
151.20
113.20
ng/l
0.52
20
143
20
143
1.40
0.70
1.7
2.3
8.43
8.33
mmol/l
0.02
20
143
9
58
1.55
0.69
1.1
1.1
—
—
—
0
0
9
58
1.55
0.69
1.1
1.1
—
—
—
0
0
14
93
1.51
0.69
1.3
1.1
105.13
228.62
iu/ml
2.03
14
93
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
17
118
1.44
0.69
1.1
1.1
—
—
—
0
0
34
266
1.28
0.68
1.1
1.1
1.44
1.27
u/ml
0.07
17
112
237
2573
0.91
0.67
5.6
5.1
33.12
33.03
%
0.05
165
1667
17
119
1.43
0.67
1.1
1.1
—
—
—
0
0
29
223
1.30
0.66
1.0
1.1
9.68
3.49
u/ml
0.63
17
113
12
78
1.54
0.65
1.5
1.2
—
—
—
0
0
24
182
1.32
0.61
1.6
1.3
—
—
—
0
0
54
453
1.20
0.61
1.5
1.4
14.50
9.49
u/l
1.29
49
355
22
165
1.34
0.60
1.3
1.6
337.69
333.51
mu/l
0.03
16
129
28
218
1.29
0.60
1.7
1.3
30.37
26.71
u/l
0.20
23
178
29
227
1.28
0.60
1.9
1.6
—
—
—
0
0
11
72
1.53
0.59
1.3
1.3
138.13
168.80
mmol/24h
0.60
11
72
10
64
1.56
0.58
1.1
1.1
—
—
—
0
0
28
220
1.28
0.57
1.8
1.8
—
—
—
0
0
5
86
0.58
0.56
1.0
1.3
—
—
—
0
0
169
1549
1.10
0.55
2.1
2.4
12.67
12.73
nmol/l
0.03
152
1374
79
692
1.15
0.55
2.1
2.0
—
—
—
0
0
101
1131
0.89
0.54
1.7
1.8
3.44
3.47
mmol/l
0.08
71
804
16
116
1.38
0.54
1.6
1.7
1.55
4.15
u/field
0.93
11
83
6
38
1.58
0.54
1.0
1.2
—
—
—
0
0
9
61
1.48
0.53
1.1
1.1
—
—
—
0
0
37
305
1.22
0.51
3.9
5.4
336.07
353.44
umol/l
0.20
29
272
93
830
1.13
0.50
2.2
2.1
—
—
—
0
0
22
172
1.28
0.48
2.0
1.4
—
—
—
0
0
11
76
1.45
0.48
1.2
1.0
—
—
—
0
0
30
248
1.21
0.43
1.6
1.6
—
—
—
0
0
163
1515
1.08
0.42
2.1
2.1
—
—
—
0
0
13
96
1.36
0.41
1.2
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
2.2
—
1.20
—
0
10
0
15
0.00
0.41
0.0
2.0
—
—
—
0
0
(46236287) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Pleural fluid by Immunoassay
0
17
0.00
0.40
0.0
1.2
—
4158.00
—
0
10
17
132
1.29
0.40
1.3
1.2
—
—
—
0
0
20
159
1.26
0.40
1.4
1.3
0.44
1.15
u/ml
0.68
13
88
0
18
0.00
0.40
0.0
1.7
—
15.00
—
0
11
150
1395
1.08
0.39
2.0
2.0
—
—
—
0
0
135
1250
1.08
0.39
1.2
1.2
119.59
132.83
u/ml
0.13
55
458
9
69
1.31
0.37
1.8
2.8
10.48
10.05
kpa
—
9
69
9
69
1.31
0.37
1.8
2.8
4.53
4.92
kpa
—
9
69
17
134
1.27
0.37
1.2
1.2
—
—
—
0
0
34
291
1.17
0.35
1.8
2.4
22.18
23.84
mg/l
0.09
11
108
17
135
1.26
0.35
1.2
1.2
—
—
—
0
0
15
117
1.28
0.35
2.4
1.5
—
—
—
0
0
15
117
1.28
0.35
2.4
1.5
—
—
—
0
0
15
117
1.28
0.35
2.4
1.5
—
—
—
0
0
15
117
1.28
0.35
2.4
1.5
—
—
—
0
0
84
917
0.91
0.33
1.0
1.0
—
—
—
0
0
34
294
1.16
0.32
1.5
1.4
27731.20
76941.22
e6/l
1.03
15
167
6
47
1.28
0.32
1.0
1.2
28.04
34.02
nmol/l
—
6
37
7
53
1.32
0.30
2.9
2.8
2.00
584.00
ug/l
—
7
53
16
129
1.24
0.30
2.4
2.3
—
—
—
0
0
12
94
1.28
0.28
1.3
1.2
—
70.62
%
—
0
13
60
546
1.10
0.28
1.6
1.4
—
—
—
0
0
9
76
1.18
0.24
1.1
1.1
—
—
—
0
0
9
76
1.18
0.24
4.8
1.2
21.56
10.11
mm/h
—
9
76
30
265
1.13
0.23
4.0
3.9
—
—
—
0
0
51
466
1.10
0.23
4.3
3.8
32.49
27.36
mg/l
0.46
40
328
5
39
1.28
0.23
1.2
1.4
—
—
—
0
0
91
854
1.07
0.22
3.1
3.2
974.61
5134.96
u/ml
0.70
86
742
67
623
1.08
0.21
1.4
1.7
5.64
4.82
mg/l
0.17
51
471
0
11
0.00
0.21
0.0
8.9
—
—
—
0
0
12
98
1.23
0.21
1.1
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
7.65
—
0
13
0
13
0.00
0.21
0.0
1.0
—
37.32
—
0
13
0
13
0.00
0.21
0.0
1.0
—
20.68
—
0
13
24
211
1.14
0.20
2.0
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
28
253
1.11
0.17
1.1
1.1
5.30
2.21
—
6
31
20
178
1.12
0.15
4.3
5.6
369.99
36.64
u/ml
—
7
58
64
677
0.94
0.15
1.5
1.4
27.81
27.74
iu/l
0.00
54
575
18
159
1.13
0.15
1.1
1.0
262.00
308.38
ng/l
0.64
13
102
14
121
1.16
0.15
1.1
1.1
38.90
15.25
u/ml
—
5
46
11
129
0.85
0.14
1.8
1.4
87.73
89.90
umol/l
0.08
11
129
18
161
1.12
0.13
1.1
1.0
999.85
657.36
ng/l
1.55
13
101
18
161
1.12
0.13
1.1
1.0
37.58
42.22
ng/l
0.23
13
101
37
345
1.07
0.12
1.6
1.5
—
—
—
0
0
54
511
1.06
0.12
1.6
1.6
1279.86
978.22
mu/l
0.82
41
432
28
258
1.09
0.12
1.0
1.0
—
—
—
0
0
12
105
1.14
0.11
1.2
1.1
1.03
1.06
ratio
0.64
12
88
16
144
1.11
0.10
1.5
1.2
—
—
—
0
0
5
44
1.14
0.10
1.0
1.1
—
—
—
0
0
5
45
1.11
0.09
2.2
2.1
—
—
—
0
0
5
46
1.09
0.09
2.2
2.1
—
—
—
0
0
5
47
1.06
0.09
1.2
1.3
—
—
—
0
0
422
4168
1.02
0.09
3.3
3.4
0.88
0.78
ug/l
0.40
290
2883
13
116
1.12
0.09
5.8
7.4
17.66
173.94
ug/l
—
8
74
9
88
1.02
0.07
3.4
1.6
—
—
—
0
0
25
264
0.95
0.06
1.6
1.5
—
—
—
0
0
24
229
1.05
0.04
3.8
2.7
—
—
—
0
0
10
92
1.09
0.03
1.1
1.3
208.44
151.63
pmol/l
—
10
92
16
168
0.95
0.02
1.2
1.2
—
—
—
0
0
26
268
0.97
0.02
1.7
1.5
0.97
1.21
ratio
1.17
18
168
26
268
0.97
0.02
1.7
1.5
0.98
0.93
ratio
0.25
18
168
26
268
0.97
0.02
1.7
1.5
1.28
1.22
ratio
0.12
18
168
22
213
1.03
0.01
1.3
1.5
—
—
—
0
0
52
527
0.99
0.01
1.3
1.2
—
—
—
0
0
18
186
0.97
0.00
1.6
1.6
73.10
53.91
ug/l
1.22
18
186
20
201
0.99
0.00
1.8
2.2
2.08
1.75
u/field
0.19
12
110
19
194
0.98
0.00
1.0
1.0
0.39
0.25
u/ml
—
6
70
7
76
0.92
0.00
1.1
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
7.70
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
58
0.86
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.8
—
25.60
—
0
5
9
92
0.98
-0.00
1.2
1.1
—
—
—
0
0
5
57
0.88
-0.00
1.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
1.48
—
0
8
8
87
0.92
-0.00
3.6
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
87
0.92
-0.00
3.6
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_BULLOUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_BULLOUS | 1.614 [1.43, 1.82] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.267 |
During the follow-up period (1.1.1998 — 31.12.2019), 2522 out of 7359 females with L12_BULLOUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_BULLOUS | 1.855 [1.6, 2.15] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 2107 out of 5767 males with L12_BULLOUS died.
Mortality risk
Mortality risk for people of age
years, who have L12_BULLOUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.124% | 0.413% |
| 5 | 0.867% | 2.001% |
| 10 | 2.293% | 4.857% |
| 15 | 4.463% | 8.924% |
| 20 | 7.786% | 14.77% |
Relationships between endpoints
↥Index endpoint: L12_BULLOUS – Bullous disorders
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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