pemphigus: a rare group of blistering autoimmune diseases that affect the skin and mucous membranes.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
249 |
4. Check minimum number of eventsNone |
249 |
5. Include endpoints |
275 |
6. Filter based on genotype QC (FinnGen only) |
241 |
Control definitions (FinnGen only)
- Control exclude
- L12_BULLOUS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L10-L14
- Name in latin
- Pemphigus
Similar endpoints
↥List of similar endpoints to
Pemphigus
based on the number of shared cases.
Similar with more cases:
- Bullous disorders
- Diseases of the skin and subcutaneous tissue
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2071 | 1164 | 893 |
| Only index persons | 1659 | 955 | 704 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 60.97 | 62.71 | 58.53 |
| Only index persons | 58.01 | 59.23 | 56.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 241 | 129 | 112 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | 57.45 | 53.36 | 62.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 255
- Matched controls
- 2550
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L10.9
ICD-10 Finland
Pemphigus, unspecified
+∞
85.3
77
*
L10.0
ICD-10 Finland
Pemphigus vulgaris
1112.0
84.6
78
*
L04AX01
ATC
azathioprine; systemic
18.1
56.9
49
33
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
8.6
52.3
83
136
L10.2
ICD-10 Finland
Pemphigus foliaceus
+∞
41.8
39
*
L10.8
ICD-10 Finland
Other pemphigus
+∞
35.2
33
*
D07AD01
ATC
clobetasol; topical
5.3
34.0
92
245
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
5.2
29.2
75
189
L12.0
ICD-10 Finland
Bullous pemphigoid
+∞
28.7
27
*
L10.4
ICD-10 Finland
Pemphigus erythematosus
+∞
26.5
25
*
H02AB06
ATC
prednisolone; systemic
3.9
23.2
175
920
J04BA02
ATC
dapsone; oral
131.9
23.0
24
*
D07AC01
ATC
betamethasone; topical
3.6
22.2
140
651
135
Kela drug reimbursment
Pemphigus
+∞
22.2
21
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.4
17.8
85
325
L10.1
ICD-10 Finland
Pemphigus vegetans
+∞
16.9
16
*
L04AX03
ATC
methotrexate; systemic
4.2
16.3
50
141
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.0
16.1
126
634
D07AB08
ATC
desonide; topical
3.7
14.6
53
168
D07BA04
ATC
hydrocortisone and antiseptics; topical
4.2
13.8
41
112
69400
ICD-8 Finland
Pemphigus, Vulgaris, vegetans, foliaceus
+∞
13.7
13
*
D07AC13
ATC
mometasone; topical
2.7
12.4
95
460
E0000UV, ,
ATC
2.4
11.1
130
762
L40.0
ICD-10 Finland
Psoriasis vulgaris
5.5
11.0
22
43
XQ848
NOMESCO Finland
Dermatological photography
5.6
10.8
21
40
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
9.8
10.7
21
23
L13.9
ICD-10 Finland
Bullous disorder, unspecified
114.5
10.5
11
*
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.9
10.0
23
51
L04AA06
ATC
mycophenolic acid; systemic
11.3
10.0
18
17
TQW80
NOMESCO Finland
Local dermatologic skincare
7.9
9.9
22
30
L12.9
ICD-10 Finland
Pemphigoid, unspecified
57.2
9.7
11
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.0
9.5
49
190
D07AB02
ATC
hydrocortisone butyrate; topical
2.4
9.4
94
506
L30.3
ICD-10 Finland
Infective dermatitis
5.1
9.2
20
42
E000001, ,
ATC
2.6
9.1
65
299
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
4.8
9.0
21
47
L10
ICD-10 Finland
Pemphigus
+∞
8.4
8
*
L12.8
ICD-10 Finland
Other pemphigoid
+∞
8.4
8
*
SBA00
NOMESCO Finland
Microbiological examinations
8.2
8.0
17
22
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.5
7.9
58
269
D07CC01
ATC
betamethasone and antibiotics; topical
2.7
7.8
47
198
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
7.7
140
936
L30.0
ICD-10 Finland
Nummular dermatitis
4.3
7.5
20
50
J01FF01
ATC
clindamycin; systemic
2.2
7.4
83
460
L10.3
ICD-10 Finland
Brazilian pemphigus [fogo selvagem]
+∞
7.3
7
*
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.3
7.2
70
366
Z3231
NOMESCO Finland
Registered nurse
2.1
7.2
86
489
ECA20
NOMESCO Finland
Biopsy of gingiva
14.3
7.0
11
8
K13.78
ICD-10 Finland
Other change in the oral mucosa
7.5
6.8
15
21
L01.1
ICD-10 Finland
Impetiginization of other dermatoses
71.6
6.5
7
*
Q82.80
ICD-10 Finland
Benign familial pemphigus [Hailey-Hailey]
71.6
6.5
7
*
A02BC02
ATC
pantoprazole; systemic
2.1
6.4
186
1434
H02AB07
ATC
prednisone; oral
2.5
6.4
45
203
S97
ICPC
Chronic ulcer skin
3.0
6.4
30
110
D07XC01
ATC
betamethasone; topical
2.5
6.2
43
193
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.4
6.2
23
73
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.0
6.1
85
506
J01DB01
ATC
cefalexin; oral
2.4
6.1
216
1780
J33.0
ICD-10 Finland
Polyp of nasal cavity
6.3
6.1
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
58
12
62.27
102.10
1.9
1.3
22.11
—
u/ml
—
18
0
182
1280
2.47
9.78
16.1
10.1
4.25
4.22
e9/l
0.07
163
1119
53
231
2.63
8.20
2.1
2.0
370.08
380.04
nmol/l
0.12
53
215
42
187
2.49
6.15
9.6
6.4
11.09
9.84
mmol/l
0.63
42
181
97
606
1.97
6.11
3.0
2.0
2.53
2.96
mg/l
1.49
91
521
19
59
3.40
5.29
1.9
1.4
—
—
—
0
0
52
275
2.12
5.08
2.1
1.9
—
—
—
0
0
65
380
1.95
4.81
2.0
2.0
—
—
—
0
0
151
1150
1.77
4.66
8.6
6.7
1.20
1.21
mmol/l
1.15
138
1008
137
1016
1.75
4.63
5.4
4.5
34.10
35.67
g/l
2.15
131
966
12
23
5.42
4.51
2.3
1.1
—
—
—
0
0
16
51
3.28
4.29
1.2
1.4
32.25
38.58
u/ml
—
6
6
137
1038
1.69
4.11
7.9
5.9
1.20
1.21
mmol/l
0.95
130
964
50
283
1.95
4.02
2.1
1.9
—
—
—
0
0
11
23
4.95
3.92
1.1
1.2
—
—
—
0
0
38
203
2.02
3.59
3.0
2.2
0.22
0.22
g/l
0.02
38
193
30
147
2.18
3.53
3.4
2.6
142.11
207.20
ng/l
0.72
30
133
63
400
1.76
3.52
2.0
1.7
1265.94
1231.77
nmol/l
0.09
54
305
75
501
1.70
3.50
2.5
1.8
3.04
1.37
mg/l
0.71
60
406
34
176
2.08
3.49
3.3
3.0
53.29
60.75
ml/min/173m2
0.47
14
72
11
28
4.06
3.33
1.5
1.4
—
—
—
0
0
192
1645
1.68
3.15
6.4
4.4
14.85
12.06
mm/h
1.66
183
1521
40
231
1.87
3.02
5.5
3.5
—
—
—
0
0
15
58
2.69
2.93
2.1
1.2
—
—
—
0
0
150
1225
1.55
2.89
6.7
6.6
10.78
11.39
umol/l
0.47
143
1158
18
77
2.44
2.89
2.5
4.1
3.89
3.09
ratio
0.11
11
44
42
250
1.81
2.89
1.7
2.8
6.06
8.17
umol/l
0.74
36
222
131
1039
1.54
2.88
4.0
3.0
150.03
116.00
ug/l
1.38
123
968
95
702
1.56
2.88
2.1
1.7
18.73
20.98
nmol/l
0.88
88
593
91
669
1.56
2.81
4.9
3.4
0.74
0.39
e6/l
0.78
71
495
195
1704
1.61
2.67
11.6
8.2
79.69
78.24
u/l
0.17
189
1607
81
586
1.56
2.66
3.5
3.1
354.50
347.52
umol/l
0.19
70
515
103
790
1.51
2.58
2.9
3.3
2.32
2.35
mmol/l
1.78
95
719
62
430
1.58
2.42
4.4
3.9
405.02
222.05
ng/l
0.41
52
342
14
58
2.50
2.41
1.4
1.6
—
—
—
0
0
124
999
1.47
2.39
2.3
2.5
77.93
77.31
nmol/l
0.08
112
891
13
53
2.53
2.31
1.4
1.6
—
—
—
0
0
12
47
2.63
2.30
1.3
1.4
—
—
—
0
0
12
47
2.63
2.30
1.3
1.4
—
—
—
0
0
96
740
1.48
2.29
3.8
3.4
2004.06
1242.10
ng/l
0.97
91
627
71
516
1.52
2.25
1.4
1.3
0.81
1.97
u/ml
1.31
15
130
9
29
3.18
2.25
1.4
1.4
—
—
—
0
0
5
9
5.64
2.22
2.4
2.7
—
—
—
0
0
35
215
1.73
2.18
4.0
2.7
33.93
30.64
u/l
0.59
30
177
141
1187
1.42
2.03
5.0
4.1
0.00
6.22
estimate
0.50
30
261
59
422
1.52
2.00
1.3
1.3
21.56
32.11
iu/ml
0.77
16
136
122
1005
1.41
1.97
2.6
2.2
93.60
94.99
pmol/l
0.12
75
520
15
71
2.18
1.96
1.8
1.2
—
—
—
0
0
41
271
1.61
1.95
7.8
6.3
0.24
0.96
mmol/l
0.28
34
230
142
1203
1.41
1.94
4.9
4.1
0.00
0.02
estimate
0.50
29
240
34
216
1.66
1.89
5.9
6.5
1.23
1.28
mmol/l
0.14
34
210
65
481
1.47
1.86
2.1
1.8
453.27
443.91
pmol/l
0.10
59
405
14
66
2.19
1.85
1.2
1.7
—
—
—
0
0
7
23
3.10
1.81
1.1
1.1
—
—
—
0
0
27
163
1.73
1.80
1.9
1.5
—
—
—
0
0
6
18
3.39
1.75
1.2
1.2
130.33
94.44
pmol/l
—
6
18
13
61
2.19
1.74
1.5
1.2
—
—
—
0
0
95
767
1.38
1.67
5.1
4.0
19.59
9.37
mg/mmol
0.50
62
477
137
1175
1.36
1.63
4.9
4.0
0.00
0.00
estimate
-0.00
30
255
13
63
2.12
1.62
1.6
1.6
—
—
—
0
0
13
63
2.12
1.62
1.5
1.7
—
—
—
0
0
21
122
1.79
1.60
1.5
1.5
—
—
—
0
0
16
86
1.92
1.54
2.9
2.8
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
11
51
2.21
1.53
3.7
2.1
0.35
0.41
iu/ml
—
6
30
7
27
2.64
1.52
1.6
2.0
9.29
10.93
mmol/l
—
7
27
9
37
2.48
1.49
1.6
1.8
—
—
—
0
0
55
412
1.43
1.47
3.7
3.2
0.92
0.85
e6/l
0.09
30
216
5
16
3.17
1.44
1.8
1.4
—
—
—
0
0
5
16
3.17
1.44
1.0
1.8
—
—
—
0
0
5
16
3.17
1.44
1.0
1.8
—
—
—
0
0
12
60
2.05
1.40
4.2
3.5
10.60
2.42
index
—
5
36
35
243
1.51
1.37
4.1
3.7
5.77
5.63
kpa
0.39
35
234
13
68
1.96
1.36
1.2
1.4
—
—
—
0
0
64
503
1.36
1.30
5.2
4.2
1.02
1.02
kg/l
1.75
46
347
5
18
2.81
1.29
1.0
3.9
161.60
1049.83
mg
—
5
18
214
2004
1.42
1.26
7.3
6.7
40.45
39.64
mmol/mol
0.58
208
1869
22
141
1.61
1.22
1.9
1.8
—
—
—
0
0
141
1249
1.29
1.20
3.2
3.0
—
—
—
0
0
11
57
1.97
1.19
1.5
1.3
—
—
—
0
0
61
487
1.33
1.11
2.3
2.9
2.45
2.46
mmol/l
0.26
55
439
8
41
1.98
1.09
1.6
1.7
—
—
—
0
0
49
382
1.35
1.05
1.3
1.3
21.27
9.61
u/ml
0.54
16
142
11
60
1.87
1.04
1.7
1.4
146.80
291.34
ug/g
—
5
33
44
338
1.36
1.03
7.9
6.1
102.39
103.96
mmol/l
1.20
44
338
9
49
1.87
0.99
1.0
1.3
—
—
—
0
0
9
49
1.87
0.99
2.1
1.5
—
—
—
0
0
7
36
1.97
0.98
1.0
1.1
—
—
—
0
0
10
56
1.82
0.89
1.3
1.1
—
7.02
—
0
6
10
56
1.82
0.89
1.5
2.0
1.97
4.21
iu/l
—
5
20
8
47
1.72
0.81
1.6
1.7
—
—
—
0
0
76
650
1.24
0.81
6.0
4.2
0.00
0.01
estimate
0.50
24
237
48
390
1.28
0.78
3.7
3.3
1.98
1.96
e6/l
0.01
22
196
219
2097
1.31
0.77
27.4
16.8
26.02
24.04
mg/l
0.42
199
1744
7
38
1.87
0.74
1.1
1.1
238.57
254.95
u/ml
—
7
22
5
26
1.94
0.71
1.0
1.5
—
—
—
0
0
7
118
0.58
0.69
1.0
1.0
—
—
—
0
0
176
1657
1.20
0.66
4.5
4.4
14.67
14.83
pmol/l
0.38
164
1508
82
723
1.20
0.64
4.0
2.4
51.66
68.92
u/l
1.25
76
677
14
199
0.69
0.64
1.2
2.1
3.67
3.40
ratio
—
9
166
116
1059
1.17
0.61
3.4
2.8
—
—
estimate
—
0
0
100
903
1.18
0.59
2.1
1.9
1.38
1.34
mmol/l
0.13
80
742
19
141
1.38
0.58
3.3
2.6
0.94
0.63
%
1.06
19
141
20
151
1.35
0.56
5.3
3.2
5.34
5.11
kpa
0.68
20
146
11
158
0.68
0.54
3.2
3.0
129.00
128.33
g/l
0.04
11
153
9
62
1.47
0.53
1.2
1.2
—
—
—
0
0
9
63
1.44
0.53
1.2
1.2
—
—
—
0
0
227
2207
1.26
0.51
20.7
12.3
25.81
24.94
u/l
0.32
221
2142
210
2032
1.19
0.45
28.2
16.7
77.11
79.39
ml/min/173m2
0.76
198
1894
5
31
1.62
0.43
1.4
1.2
—
—
—
0
0
13
96
1.37
0.42
1.2
1.4
—
—
—
0
0
54
608
0.86
0.42
5.0
4.7
22.83
22.39
%
0.07
24
304
8
59
1.37
0.41
1.3
1.8
—
—
—
0
0
5
37
1.36
0.37
2.2
1.8
—
—
—
0
0
96
892
1.12
0.36
4.5
4.2
40.73
38.04
ng/l
0.08
69
660
61
671
0.88
0.35
4.5
3.5
0.00
0.00
estimate
-0.00
25
203
13
100
1.32
0.34
4.1
3.6
1.85
1.49
%
0.28
13
94
18
220
0.80
0.34
1.8
2.2
—
—
—
0
0
17
205
0.82
0.29
1.8
2.0
—
—
—
0
0
8
63
1.28
0.28
2.8
1.3
—
—
—
0
0
230
2262
1.17
0.27
41.7
25.5
254.36
247.86
e9/l
0.68
224
2226
230
2263
1.17
0.26
41.6
25.4
4.36
4.46
e12/l
1.95
223
2219
202
1974
1.11
0.25
5.6
5.4
1.91
1.93
mu/l
0.10
188
1809
200
2044
0.90
0.25
5.4
5.3
6.05
5.99
mmol/l
0.27
189
1876
59
545
1.11
0.25
3.7
2.4
—
—
—
0
0
40
362
1.12
0.24
2.1
1.6
—
—
—
0
0
24
210
1.16
0.22
3.0
3.1
3.89
4.50
kpa
1.08
24
199
0
10
0.00
0.21
0.0
3.2
—
42.81
—
0
10
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
13
0.00
0.21
0.0
3.9
—
205.23
—
0
13
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
43
465
0.91
0.19
3.4
3.3
0.88
0.77
ug/l
0.20
25
291
21
185
1.15
0.18
2.1
1.4
—
—
—
0
0
5
67
0.74
0.17
1.2
1.7
—
—
—
0
0
8
72
1.11
0.16
4.9
4.3
23.86
25.37
mmol/l
—
8
67
6
76
0.78
0.16
1.0
1.6
—
—
—
0
0
93
895
1.06
0.15
5.5
4.0
0.00
0.02
estimate
0.88
25
211
9
83
1.09
0.15
2.7
2.1
—
—
—
0
0
8
97
0.82
0.14
1.8
2.0
—
—
—
0
0
14
159
0.87
0.13
2.6
2.5
—
21.60
—
0
8
34
317
1.08
0.12
1.2
1.6
—
—
—
0
0
5
46
1.09
0.09
1.8
1.7
—
—
—
0
0
5
48
1.04
0.09
7.8
2.1
11.62
7.82
pmol/l
—
5
48
209
2110
0.95
0.09
6.1
6.0
2.65
2.65
mmol/l
0.02
199
1946
75
764
0.97
0.04
5.1
5.5
1.97
2.66
ug/l
0.59
65
679
198
1969
1.02
0.03
4.5
4.4
1.36
1.26
mmol/l
1.26
183
1797
208
2070
1.03
0.02
5.3
5.3
4.62
4.56
mmol/l
0.30
196
1913
15
142
1.06
0.02
2.3
2.7
1.13
1.32
%
0.55
15
142
11
117
0.94
0.02
2.1
2.0
—
—
—
0
0
207
2063
1.02
0.01
5.2
5.2
1.43
1.46
mmol/l
0.49
194
1894
14
146
0.96
0.00
1.5
1.2
127.67
145.01
u/ml
—
6
58
25
247
1.01
0.00
10.6
7.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
64.29
—
0
9
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
1.18
—
0
5
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
88.94
—
0
5
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
80
1.00
-0.00
2.3
1.9
—
—
—
0
0
5
56
0.89
-0.00
1.2
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_PEMPHIGUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PEMPHIGUS | 1.626 [1.33, 1.99] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.595 |
During the follow-up period (1.1.1998 — 31.12.2019), 277 out of 914 females with L12_PEMPHIGUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PEMPHIGUS | 1.956 [1.45, 2.64] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 244 out of 706 males with L12_PEMPHIGUS died.
Mortality risk
Mortality risk for people of age
years, who have L12_PEMPHIGUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.18% | 0.394% |
| 5 | 1.082% | 2.301% |
| 10 | 2.535% | 5.646% |
| 15 | 4.777% | 10.27% |
| 20 | 8.552% | 17.108% |
Relationships between endpoints
↥Index endpoint: L12_PEMPHIGUS – Pemphigus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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