vesiculobullous skin disease: Skin diseases characterized by local or general distributions of vesicles and bullae (i.e. blisters). Both vesicles and bullae are fluid-filled lesions, distinguished by size (vesicles being less than 5–10 mm and bullae being larger than 5–10 mm). Vesiculobullous diseases are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. In the case of vesiculobullous diseases which are also immune disorders, the term immunobullous is sometimes used. (From Scientific American Medicine, 1990, and Wikipedia)
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
442 |
4. Check minimum number of eventsNone |
442 |
5. Include endpointsNone |
442 |
6. Filter based on genotype QC (FinnGen only) |
406 |
Control definitions (FinnGen only)
- Control exclude
- L12_BULLOUS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF6
- Parent code in ICD-10
- L10-L14
- Name in latin
- Aliae morbositates bullosae
Similar endpoints
↥List of similar endpoints to
Other and unspecified bullous disorders
based on the number of shared cases.
Similar with more cases:
- Other bullous disorders
- Bullous disorders
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2861 | 1586 | 1258 |
| Only index persons | 2371 | 1363 | 1008 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.04 |
| Only index persons | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 55.73 | 56.47 | 54.87 |
| Only index persons | 56.95 | 56.76 | 57.21 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 406 | 247 | 159 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.07 |
| Median age at first event (years) | 62.42 | 60.62 | 65.21 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 415
- Matched controls
- 4150
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L13.9
ICD-10 Finland
Bullous disorder, unspecified
7648.9
307.7
329
*
L13.8
ICD-10 Finland
Other specified bullous disorders
304.1
76.2
75
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
7.0
61.2
113
212
L12.0
ICD-10 Finland
Bullous pemphigoid
669.3
60.3
58
*
TQW80
NOMESCO Finland
Local dermatologic skincare
13.4
52.4
52
44
L30.9
ICD-10 Finland
Dermatitis, unspecified
4.1
40.5
159
546
J04BA02
ATC
dapsone; oral
95.4
32.3
35
*
D07AD01
ATC
clobetasol; topical
3.8
31.8
125
421
D07AC01
ATC
betamethasone; topical
3.2
29.4
214
1045
L13.0
ICD-10 Finland
Dermatitis herpetiformis
300.8
28.1
28
*
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
3.8
27.2
101
324
L12.9
ICD-10 Finland
Pemphigoid, unspecified
81.1
20.9
23
*
XQ848
NOMESCO Finland
Dermatological photography
6.6
18.7
31
50
A46
ICD-10 Finland
Erysipelas
3.0
17.3
90
349
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.7
17.3
42
97
H02AB06
ATC
prednisolone; systemic
2.4
16.7
238
1493
E0000UV, ,
ATC
2.4
16.7
217
1308
L04AX03
ATC
methotrexate; systemic
3.2
15.6
69
243
D07AB08
ATC
desonide; topical
3.1
15.1
73
271
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
14.5
178
1031
R06AE07
ATC
cetirizine; oral
2.2
14.2
212
1328
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.2
13.3
57
196
J01FF01
ATC
clindamycin; systemic
2.3
13.2
137
734
XQ802
NOMESCO Finland
Epicutan test
4.5
12.9
32
75
R60.0
ICD-10 Finland
Localized oedema
2.7
12.8
78
327
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.8
12.3
71
289
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.7
12.2
76
321
E000001, ,
ATC
2.4
11.9
105
522
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.7
11.6
27
60
D07AC13
ATC
mometasone; topical
2.1
11.5
143
817
S29
ICPC
Skin symptom/complaint other
2.3
11.5
112
580
J01DB01
ATC
cefalexin; oral
2.7
11.4
361
2943
D07BC01
ATC
betamethasone and antiseptics; topical
2.7
11.0
63
254
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.7
11.0
66
273
C03CA01
ATC
furosemide; systemic
2.1
10.8
149
882
S76
ICPC
Skin infection other
3.6
10.7
37
111
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
4.7
10.6
25
56
S97
ICPC
Chronic ulcer skin
3.2
10.5
44
149
D07AB02
ATC
hydrocortisone butyrate; topical
2.1
10.3
144
854
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
10.3
73
328
H02AB09
ATC
hydrocortisone; systemic
5.2
10.2
21
42
WZC00
NOMESCO Finland
Treatment plan or consultation
2.0
10.0
173
1104
L30.3
ICD-10 Finland
Infective dermatitis
4.3
9.8
26
64
L04AX01
ATC
azathioprine; systemic
4.0
9.8
28
73
ZX120
NOMESCO Finland
Intravenous
2.7
9.7
56
227
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.5
9.7
65
284
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.7
9.2
54
220
D05BB02
ATC
acitretin; oral
5.2
9.2
19
38
J05AB11
ATC
valaciclovir; oral
2.3
9.0
82
409
D02AX
ATC
Other emollients and protectives
4.1
9.0
25
64
S18
ICPC
Laceration/cut
1.9
9.0
215
1512
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.7
9.0
53
217
Z71.8
ICD-10 Finland
Other specified counselling
1.9
8.8
164
1062
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.2
8.7
36
121
K90.0
ICD-10 Finland
Coeliac disease
4.3
8.6
22
53
J01CF05
ATC
flucloxacillin; systemic
2.8
8.5
44
168
R60.9
ICD-10 Finland
Oedema, unspecified
3.2
8.5
34
112
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
8.4
93
501
H02AB04
ATC
methylprednisolone; systemic
2.3
8.4
73
357
A10AE04
ATC
insulin glargine; parenteral
2.6
8.3
53
225
L13
ICD-10 Finland
Other bullous disorders
34.1
8.1
10
*
R50.9
ICD-10 Finland
Fever, unspecified
2.2
8.1
80
412
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.0
8.1
115
678
Z3231
NOMESCO Finland
Registered nurse
1.9
8.1
131
807
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.3
8.0
68
329
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
6.3
7.9
20
33
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.2
7.8
69
339
A02BC02
ATC
pantoprazole; systemic
1.9
7.8
291
2305
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.3
7.7
29
92
ZY010
NOMESCO Finland
Hospital outpatient
3.0
7.7
34
119
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.4
7.7
58
267
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
7.6
133
836
L08.8
ICD-10 Finland
Other specified local infections of skin and subcutaneous tissue
3.9
7.6
22
58
K11.70
ICD-10 Finland
Hypoptyalism
25.5
7.6
10
*
J01MA12
ATC
levofloxacin; systemic
2.1
7.6
85
459
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.0
7.6
34
120
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
7.6
213
1547
S17
ICPC
Abrasion/scratch/blister
4.0
7.5
21
54
J01MA02
ATC
ciprofloxacin; systemic
1.8
7.5
168
1141
L29.9
ICD-10 Finland
Pruritus, unspecified
4.3
7.4
19
46
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
7.3
69
349
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.9
7.2
35
129
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.1
7.2
80
430
D07XC01
ATC
betamethasone; topical
2.3
7.1
59
282
XQ800
NOMESCO Finland
Prick test
2.7
7.1
40
160
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.9
7.1
33
119
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.8
7.0
36
137
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.8
6.9
130
834
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
6.8
118
737
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
4.4
6.8
17
40
103
Kela drug reimbursment
Diabetes, insulin-treated
1.8
6.8
119
747
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
6.7
85
478
A10AB05
ATC
insulin aspart; parenteral
2.5
6.7
42
177
JN3AD
NOMESCO Finland
Abdominal CT examination
2.2
6.7
63
318
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.4
6.7
24
74
N30.0
ICD-10 Finland
Acute cystitis
2.0
6.6
80
443
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.9
6.6
109
670
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.0
6.6
79
437
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.4
6.5
23
70
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
4.0
6.5
18
46
R06AX27
ATC
desloratadine; oral
1.8
6.5
123
788
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
6.5
100
601
D09AB01
ATC
zinc bandage without supplements; topical
7.6
6.5
14
19
R4110
NOMESCO Finland
Physiotherapy
1.8
6.5
125
806
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.0
6.4
28
97
A01
ICPC
Pain general/multiple sites
2.2
6.3
55
268
H3603, E103,
ICD-10 Finland
18.4
6.3
9
5
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.1
6.3
60
304
N02BE01
ATC
paracetamol; systemic, rectal
2.3
6.3
372
3287
L10.9
ICD-10 Finland
Pemphigus, unspecified
+∞
6.3
6
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.4
6.2
46
209
L51.9
ICD-10 Finland
Erythema multiforme, unspecified
27.1
6.2
8
*
SPAT1099
SPAT
Measurement of blood pressure with Doppler ultrasound device
3.6
6.2
20
57
R06.0
ICD-10 Finland
Dyspnoea
1.8
6.2
125
815
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.1
6.2
64
335
XW000
NOMESCO Finland
Bone marrow biopsy
3.2
6.1
24
78
L08.0
ICD-10 Finland
Pyoderma
10.2
6.1
11
11
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
4.0
6.0
17
44
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
110
24
62.00
192.89
1.8
1.1
34.47
—
u/ml
—
34
0
98
28
45.51
160.31
1.5
1.2
1326.25
—
titre
—
8
0
31
39
8.51
23.31
1.3
1.3
—
—
—
0
0
320
2166
3.09
21.38
15.1
9.8
4.28
4.05
e9/l
1.00
290
1889
286
1909
2.60
18.09
11.1
7.3
1.21
1.21
mmol/l
0.33
270
1656
251
1642
2.34
15.60
7.0
4.9
34.09
35.85
g/l
4.55
243
1552
240
1618
2.15
12.86
2.5
2.2
96.43
96.61
pmol/l
0.02
143
833
104
509
2.39
12.26
7.3
7.3
103.23
103.99
mmol/l
0.71
104
509
125
669
2.24
11.92
3.9
2.5
11.47
13.08
umol/l
1.90
118
627
248
1735
2.07
11.54
10.0
6.5
1.21
1.21
mmol/l
0.76
238
1606
195
1251
2.05
11.52
4.6
3.4
30.95
101.13
e6/l
0.74
161
970
157
937
2.09
11.22
1.6
1.3
3.73
1.36
u/ml
0.63
47
247
164
997
2.07
11.14
2.7
2.2
3.07
2.97
mg/l
0.21
146
871
96
479
2.31
10.70
2.1
1.9
—
—
—
0
0
213
1437
1.99
10.67
5.7
4.1
160.50
123.39
e6/l
0.17
167
1022
84
396
2.41
10.65
6.0
4.1
2.12
1.75
mmol/l
0.46
72
338
117
653
2.10
9.79
4.2
3.2
1.33
1.05
e6/l
0.32
75
343
168
1074
1.95
9.57
4.6
3.3
0.22
0.49
e6/l
1.83
131
792
343
2800
2.30
9.56
13.0
8.4
83.05
81.42
u/l
0.26
333
2651
110
613
2.08
9.17
4.3
3.3
3.31
2.59
e6/l
0.36
65
304
268
2023
1.92
8.97
5.2
4.1
0.00
0.79
estimate
0.51
48
390
266
2007
1.91
8.87
5.3
4.0
0.02
0.00
estimate
0.49
51
421
33
104
3.36
8.84
4.1
3.1
4.73
1.58
index
0.43
15
64
264
1990
1.90
8.79
5.2
4.0
0.00
0.00
estimate
-0.00
48
412
87
453
2.16
8.61
2.1
2.0
—
—
—
0
0
140
872
1.91
8.41
3.2
2.6
6.01
5.46
e6/l
0.15
127
804
239
1761
1.84
8.39
4.4
3.0
142.40
120.34
ug/l
0.64
231
1651
397
3552
3.71
7.80
30.9
16.1
23.61
23.24
mg/l
0.08
354
2919
233
1727
1.80
7.79
14.9
13.5
1.24
1.23
inr
0.10
198
1432
58
268
2.35
7.60
1.9
1.6
—
—
—
0
0
302
2434
1.88
7.53
6.5
4.8
8794.25
223.80
e6/l
—
8
41
329
2728
1.99
7.51
6.8
4.5
13.73
11.97
mm/h
1.34
320
2541
109
649
1.92
7.37
2.6
2.0
—
—
—
0
0
260
2012
1.78
7.30
8.5
6.7
11.17
11.75
umol/l
0.43
251
1916
18
30
6.22
7.15
1.1
1.2
—
—
—
0
0
17
39
4.50
7.02
1.2
1.2
—
—
—
0
0
40
163
2.61
6.83
1.7
1.9
6.28
6.72
iu/ml
—
9
43
222
1664
1.72
6.78
3.3
2.6
78.36
76.89
nmol/l
0.34
210
1502
165
1140
1.74
6.76
2.1
1.7
19.59
20.67
nmol/l
0.41
154
950
40
164
2.59
6.75
4.4
4.3
1.42
1.53
%
0.47
40
154
15
22
7.03
6.57
1.1
2.5
—
—
—
0
0
34
130
2.76
6.57
4.4
2.0
267.10
283.52
ug/l
0.05
34
123
28
96
3.06
6.56
1.5
1.2
—
—
—
0
0
174
1232
1.71
6.46
4.4
4.0
9.77
9.63
mg/mmol
0.02
121
749
39
164
2.52
6.26
3.1
2.2
7.14
7.43
g/l
0.57
39
150
39
164
2.52
6.26
3.1
2.2
3.53
3.84
g/l
0.54
39
150
39
164
2.52
6.26
3.1
2.2
4.22
4.30
g/l
0.22
39
150
167
1178
1.70
6.23
4.1
3.4
1398.25
1291.66
ng/l
0.12
150
1015
10
8
12.77
6.11
1.0
1.0
—
—
—
0
0
179
1293
1.68
6.07
4.2
3.2
7.07
7.47
mmol/l
0.57
161
1095
76
429
1.94
5.92
7.4
7.7
11.95
12.32
kpa
0.21
76
415
76
429
1.94
5.92
7.4
7.7
5.16
5.12
kpa
0.13
76
413
103
644
1.80
5.83
2.0
1.7
1139.38
1180.95
nmol/l
0.14
82
483
10
9
11.35
5.82
1.1
1.0
108.00
79.00
%
—
10
9
54
272
2.13
5.74
3.6
4.1
5.31
5.09
kpa
0.93
54
261
161
1144
1.67
5.74
3.1
2.1
147.97
240.19
u/l
0.90
155
1092
125
842
1.69
5.40
2.2
1.8
1.75
1.30
mg/l
0.36
101
670
27
102
2.76
5.35
1.2
1.2
—
—
—
0
0
9
8
11.46
5.31
1.0
1.0
—
—
—
0
0
66
369
1.94
5.27
4.7
3.5
—
—
—
0
0
220
1716
1.60
5.23
3.2
2.8
—
—
estimate
—
0
0
177
1314
1.61
5.16
4.2
3.3
2.35
2.36
mmol/l
0.41
162
1189
35
155
2.37
5.05
3.3
2.3
2.97
2.98
g/l
0.02
35
141
72
421
1.86
5.02
7.4
7.9
0.94
0.95
mmol/l
0.01
65
357
54
289
2.00
4.88
2.2
2.5
7.06
5.57
ug/l
0.22
45
258
269
2223
1.60
4.84
7.7
5.0
7.04
6.61
mmol/l
2.24
263
2107
28
114
2.56
4.82
3.5
2.4
0.00
0.00
g/l
-0.00
28
109
42
207
2.14
4.72
1.6
1.4
—
—
—
0
0
25
98
2.65
4.64
1.4
1.2
—
55.40
—
0
11
189
1453
1.55
4.59
5.5
4.0
317.04
97.54
ng/l
0.34
142
1040
127
893
1.61
4.52
2.7
2.3
—
—
—
0
0
133
952
1.58
4.38
4.0
2.9
326.03
345.03
umol/l
1.20
115
828
41
208
2.08
4.29
2.6
3.9
4.29
4.51
pmol/l
0.67
34
183
112
774
1.61
4.25
2.1
1.8
434.59
8783180.87
pmol/l
0.50
93
649
9
13
7.05
4.18
2.4
1.0
9.35
9.59
ug/l
—
9
13
10
17
6.00
4.15
1.1
1.0
1721.70
1551.06
miu/ml
—
10
17
19
70
2.80
3.97
2.2
1.3
—
—
—
0
0
61
365
1.79
3.93
7.6
8.3
121.70
119.50
g/l
0.37
61
357
321
2826
1.60
3.89
6.1
4.3
14.91
14.79
pmol/l
0.36
308
2571
43
232
1.95
3.82
3.4
4.4
1.94
1.81
mmol/l
0.09
30
165
71
448
1.71
3.81
3.3
3.1
12.14
8.68
umol/l
0.31
61
396
159
1214
1.50
3.81
4.4
2.5
55.68
64.65
u/l
0.75
149
1136
99
681
1.60
3.79
1.7
1.6
—
—
—
0
0
18
67
2.76
3.70
2.7
3.4
—
4131.17
—
0
6
43
235
1.93
3.68
6.4
6.2
24.64
24.74
mmol/l
0.07
43
224
364
3323
1.78
3.66
7.3
5.3
1.99
1.94
mu/l
0.34
349
3066
23
98
2.43
3.64
2.5
1.5
—
—
—
0
0
108
765
1.56
3.64
2.5
2.8
2.45
2.46
mmol/l
0.45
99
684
17
62
2.82
3.63
1.0
1.1
2.17
3.75
u/ml
—
6
24
19
74
2.64
3.60
1.5
1.5
—
—
—
0
0
366
3353
1.78
3.55
28.0
15.9
79.37
80.64
ml/min/173m2
0.48
345
3123
17
64
2.73
3.44
2.4
1.3
170.86
164.97
au/ml
—
7
18
18
70
2.64
3.43
1.3
1.2
202.67
231.39
u/ml
—
9
31
9
18
5.09
3.39
1.4
2.4
743.11
912.06
u/ml
—
9
18
7
11
6.45
3.19
2.0
3.1
0.62
0.59
mmol/l
—
7
11
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
22
98
2.31
3.18
3.0
2.5
0.41
0.36
iu/ml
0.26
12
52
25
118
2.19
3.17
1.6
1.6
—
—
—
0
0
99
708
1.52
3.16
1.5
1.3
16.33
29.04
iu/ml
1.77
31
220
15
56
2.74
3.09
1.1
1.1
1.33
1.35
u/ml
—
6
17
50
306
1.72
3.00
2.6
2.6
61.65
64.92
ml/min/173m2
0.20
21
132
22
101
2.24
2.98
1.4
1.5
—
—
—
0
0
15
58
2.65
2.90
1.0
1.1
—
—
—
0
0
160
1278
1.41
2.85
3.4
3.5
32.32
33.12
u/l
0.10
153
1218
58
375
1.64
2.84
2.5
2.6
36.66
31.66
u/l
0.38
50
309
12
39
3.14
2.79
4.7
2.5
11.83
12.70
index
—
6
27
358
3309
1.60
2.75
9.2
6.6
41.33
39.27
mmol/mol
3.03
344
3108
184
1512
1.39
2.75
5.1
3.9
0.07
0.03
estimate
0.25
41
343
23
112
2.12
2.73
1.5
1.3
176.36
316.30
ug/g
2.31
13
64
25
126
2.05
2.72
1.8
1.2
—
—
—
0
0
19
86
2.27
2.68
1.3
1.5
—
—
—
0
0
12
41
2.98
2.64
2.3
1.4
—
—
—
0
0
12
42
2.91
2.57
1.8
1.4
—
—
—
0
0
274
2421
1.39
2.55
4.5
3.4
58.93
48.64
u/l
1.15
265
2286
90
661
1.46
2.49
1.4
1.3
4.01
10.14
u/ml
1.11
27
256
10
32
3.18
2.45
4.6
3.2
468.40
1028.38
mg
—
10
32
17
77
2.26
2.41
1.5
1.4
—
—
—
0
0
17
77
2.26
2.41
1.5
1.4
—
—
—
0
0
39
238
1.70
2.39
2.2
1.7
—
—
—
0
0
18
84
2.19
2.38
1.5
1.5
—
—
—
0
0
5
8
6.31
2.38
1.0
1.0
—
—
—
0
0
7
17
4.17
2.37
1.4
1.1
—
—
—
0
0
33
193
1.77
2.34
9.7
9.3
16.58
15.67
%
1.16
33
185
15
65
2.36
2.34
1.4
1.6
—
—
—
0
0
98
740
1.42
2.34
5.6
3.9
27.37
264.60
ng/l
3.64
77
582
24
127
1.94
2.31
1.6
1.5
47.32
9.44
u/ml
—
5
21
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
6
13
4.67
2.28
1.8
3.1
150.50
140.15
%
—
6
13
140
1134
1.35
2.18
4.9
4.1
0.00
0.01
estimate
0.50
43
388
10
37
2.74
2.08
1.1
1.2
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
5
10
5.05
2.07
1.8
1.0
101.00
127.80
%
—
5
10
13
56
2.36
2.07
1.3
1.4
—
—
—
0
0
10
38
2.67
2.01
1.1
1.2
—
—
—
0
0
10
38
2.67
2.01
1.1
1.2
—
—
—
0
0
19
102
1.90
1.79
1.9
1.2
—
—
—
0
0
20
110
1.86
1.76
1.1
1.8
—
—
—
0
0
9
36
2.53
1.75
1.1
1.2
—
—
—
0
0
360
3402
1.44
1.75
6.1
5.2
6.14
5.94
mmol/l
1.94
349
3127
19
103
1.89
1.74
1.9
2.4
10.69
13.02
mg/l
0.70
19
98
56
404
1.45
1.71
12.1
7.7
—
—
—
0
0
19
104
1.87
1.70
2.4
1.7
—
—
—
0
0
20
112
1.83
1.67
2.4
1.7
—
—
—
0
0
8
31
2.61
1.66
1.0
1.1
—
—
—
0
0
10
42
2.41
1.63
1.1
1.1
—
—
—
0
0
14
70
2.03
1.61
1.4
1.7
—
—
—
0
0
110
898
1.31
1.57
4.8
4.1
1.02
1.02
kg/l
0.12
78
602
10
44
2.30
1.56
1.1
1.1
—
—
—
0
0
14
71
2.01
1.55
2.5
1.9
—
—
—
0
0
8
33
2.45
1.54
1.9
1.9
—
—
—
0
0
11
51
2.19
1.52
1.1
1.7
—
—
—
0
0
6
21
2.88
1.51
2.8
1.3
—
—
—
0
0
6
21
2.88
1.51
1.2
1.0
—
—
—
0
0
6
21
2.88
1.51
2.8
1.3
—
—
—
0
0
5
16
3.15
1.44
1.2
2.1
—
—
—
0
0
5
16
3.15
1.44
1.2
2.1
—
—
—
0
0
20
118
1.73
1.44
1.5
1.3
—
—
—
0
0
6
22
2.75
1.44
2.8
1.3
120.67
81.11
ng/l
—
6
22
20
119
1.72
1.40
10.0
4.0
2.09
1.96
ratio
0.04
11
66
129
1092
1.26
1.38
4.7
3.4
0.37
0.08
estimate
0.51
38
330
6
23
2.63
1.37
1.7
4.3
105.33
96.91
%
—
6
23
6
23
2.63
1.37
1.0
1.1
—
—
—
0
0
346
3283
1.32
1.33
5.0
4.3
1.36
1.27
mmol/l
1.61
324
3018
243
2213
1.24
1.33
3.2
3.1
—
—
—
0
0
18
106
1.73
1.31
1.3
1.4
—
—
—
0
0
6
25
2.42
1.25
2.8
1.4
—
—
—
0
0
6
25
2.42
1.25
2.8
1.4
—
—
—
0
0
11
56
1.99
1.23
1.0
1.4
0.14
0.39
nmol/l
—
5
41
8
37
2.18
1.22
7.0
2.4
—
—
—
0
0
54
414
1.35
1.20
1.6
1.8
1.43
1.49
%
0.25
46
362
8
40
2.02
1.12
1.0
1.1
—
—
—
0
0
18
112
1.63
1.10
1.3
1.2
—
—
—
0
0
365
3512
1.33
1.08
6.6
5.9
2.57
2.68
mmol/l
1.62
347
3258
18
113
1.62
1.07
1.3
1.2
—
—
—
0
0
5
22
2.29
1.03
3.0
3.7
4.40
0.91
%
—
5
22
30
214
1.43
1.03
2.6
2.1
—
—
—
0
0
25
175
1.46
0.95
2.5
2.0
—
—
—
0
0
6
27
2.24
0.94
4.2
2.7
0.83
0.85
index
—
6
27
6
27
2.24
0.94
1.0
1.0
—
—
—
0
0
359
3463
1.27
0.91
5.9
5.2
4.40
4.61
mmol/l
3.50
342
3223
8
42
1.92
0.89
1.0
1.1
—
—
—
0
0
8
44
1.83
0.86
3.5
1.9
—
—
—
0
0
14
88
1.61
0.85
1.1
1.3
3.61
3.85
mmol/l
0.56
14
82
20
138
1.47
0.83
2.7
1.7
—
—
—
0
0
8
46
1.75
0.83
2.6
3.1
10.70
9.43
umol/l
—
8
32
21
147
1.45
0.82
3.5
1.9
—
—
—
0
0
8
47
1.72
0.81
1.4
1.5
—
—
—
0
0
8
47
1.72
0.81
1.4
1.5
—
—
—
0
0
8
47
1.72
0.81
1.4
1.5
—
—
—
0
0
49
395
1.27
0.80
2.7
2.2
—
—
—
0
0
39
306
1.30
0.78
8.1
4.1
156.91
80.04
ng/l
1.46
32
269
356
3445
1.23
0.77
5.8
5.1
1.40
1.48
mmol/l
2.99
336
3186
7
38
1.86
0.74
1.3
1.2
—
—
—
0
0
7
39
1.81
0.73
1.1
1.2
—
—
—
0
0
13
84
1.57
0.72
2.5
2.6
391.25
102.69
ug/min
—
8
47
7
40
1.76
0.71
3.9
2.0
—
—
—
0
0
17
121
1.42
0.63
2.3
2.1
1452.00
3863.28
u/l
—
5
46
8
53
1.52
0.58
1.4
1.7
—
—
—
0
0
6
36
1.68
0.57
2.0
1.2
345.17
310.09
u/l
—
6
36
6
36
1.68
0.57
1.0
1.2
107.33
99.67
pmol/l
—
6
36
6
38
1.59
0.54
4.3
1.7
—
—
—
0
0
6
38
1.59
0.54
4.3
1.7
—
—
—
0
0
6
38
1.59
0.54
1.3
1.6
—
—
—
0
0
6
38
1.59
0.54
4.3
1.7
—
—
—
0
0
20
154
1.31
0.49
1.8
1.4
0.36
0.31
mg/l
0.13
11
54
7
45
1.56
0.49
1.3
1.5
—
—
—
0
0
7
46
1.53
0.48
1.3
1.5
—
—
—
0
0
7
46
1.53
0.48
1.3
1.5
—
—
—
0
0
7
48
1.47
0.47
1.0
1.0
—
—
—
0
0
43
367
1.19
0.46
2.5
2.0
—
—
—
0
0
7
49
1.44
0.46
1.0
1.2
—
—
—
0
0
14
104
1.36
0.43
1.5
1.7
44.36
39.79
nmol/l
0.20
14
99
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
98.81
—
0
16
16
123
1.31
0.41
1.5
1.6
—
—
—
0
0
5
35
1.43
0.39
1.2
1.1
2.17
1.70
nmol/l
—
5
30
9
68
1.33
0.38
1.0
1.3
—
—
—
0
0
9
68
1.33
0.38
1.0
1.3
—
197.14
—
0
7
8
112
0.71
0.37
1.4
1.1
0.95
0.88
g/l
—
8
112
10
73
1.38
0.35
2.0
1.5
—
—
—
0
0
39
444
0.87
0.34
6.6
4.9
30.03
32.00
%
0.50
31
287
10
74
1.36
0.32
5.2
3.5
27.10
33.48
u/ml
—
10
74
11
83
1.33
0.32
1.4
1.7
181.18
228.66
pmol/l
0.79
11
74
15
119
1.27
0.32
1.1
1.4
—
269.08
—
0
54
33
286
1.17
0.32
1.5
1.4
—
—
—
0
0
8
107
0.74
0.29
1.5
1.1
1.30
1.55
g/l
—
8
107
46
414
1.12
0.28
3.6
4.3
12.26
38.67
ug/l
0.66
37
345
9
77
1.17
0.24
6.0
2.5
9.68
8.25
pmol/l
—
9
77
23
199
1.16
0.24
1.0
1.0
—
—
—
0
0
7
93
0.75
0.22
1.4
1.3
—
—
—
0
0
13
107
1.22
0.22
1.7
1.4
—
—
—
0
0
5
42
1.19
0.21
2.2
4.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
14.48
—
0
5
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
156
1510
1.05
0.18
2.2
1.9
1.43
1.34
mmol/l
0.75
138
1284
105
1005
1.06
0.18
5.6
5.6
2.11
2.76
ug/l
0.42
99
904
13
110
1.19
0.17
2.2
1.5
—
—
—
0
0
24
216
1.12
0.16
7.6
3.0
38.48
104.04
u/ml
0.60
24
210
15
130
1.16
0.16
2.9
2.6
—
—
—
0
0
28
257
1.10
0.13
1.2
1.2
26.40
126.60
u/ml
—
8
101
21
190
1.11
0.13
1.4
1.3
—
—
—
0
0
6
55
1.09
0.09
1.5
1.3
—
—
—
0
0
79
801
0.98
0.02
5.3
4.8
24.02
21.96
%
0.47
34
399
10
93
1.08
0.02
1.3
1.4
—
—
—
0
0
58
589
0.98
0.02
3.1
3.3
0.96
0.80
ug/l
0.30
43
374
35
352
0.99
0.00
1.7
2.0
3.66
3.36
ratio
0.87
28
284
27
269
1.00
0.00
1.6
1.8
3.42
3.38
mmol/l
0.07
19
200
56
561
1.00
0.00
1.8
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
88.50
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
8.2
—
10.50
—
0
6
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.6
—
67.04
—
0
5
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
59
1.02
-0.00
2.8
2.9
3.55
69.07
u/ml
—
6
59
0
8
0.00
-0.00
0.0
1.1
—
1.18
—
0
8
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_OTHERBULL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHERBULL | 1.902 [1.48, 2.45] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.074 |
During the follow-up period (1.1.1998 — 31.12.2019), 276 out of 1248 females with L12_OTHERBULL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHERBULL | 2.2 [1.6, 3.02] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 245 out of 961 males with L12_OTHERBULL died.
Mortality risk
Mortality risk for people of age
years, who have L12_OTHERBULL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.175% | 0.288% |
| 5 | 1.006% | 2.259% |
| 10 | 2.608% | 6.262% |
| 15 | 4.971% | 11.153% |
| 20 | 8.711% | 18.21% |
Relationships between endpoints
↥Index endpoint: L12_OTHERBULL – Other and unspecified bullous disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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