Bullous pemphigoid

L12_PEMPHIGOID_BULL

bullous pemphigoid: Bullous pemphigoid (BP) is the most common form of autoimmune bullous dermatosis.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L12.0
  • Cause of death: ICD-10 L12.0

2 out of 7 registries used, show all original rules.

900

4. Check minimum number of events

None

900

5. Include endpoints

None

900

6. Filter based on genotype QC (FinnGen only)

814

Control definitions (FinnGen only)

Control exclude
L12_BULLOUS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L12
Name in latin
Pemphigoides bullosus

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6427 3635 2742
Only index persons 5536 3158 2378
Unadjusted period prevalence (%)
Whole population 0.09 0.10 0.08
Only index persons 0.11 0.12 0.09
Median age at first event (years)
Whole population 78.57 79.60 77.21
Only index persons 78.21 79.15 76.97

-FinnGen-

Key figures

All Female Male
Number of individuals 814 373 441
Unadjusted period prevalence (%) 0.17 0.13 0.20
Median age at first event (years) 75.15 73.51 76.53

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
829
Matched controls
8290
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D07AD01
ATC
clobetasol; topical
13.0
319.3
478
785
L12.0
ICD-10 Finland
Bullous pemphigoid
+∞
307.7
829
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
15.0
307.7
427
549
L30.9
ICD-10 Finland
Dermatitis, unspecified
6.4
152.0
379
966
D07AC01
ATC
betamethasone; topical
6.3
145.3
568
2128
L12.9
ICD-10 Finland
Pemphigoid, unspecified
403.2
137.0
134
*
TQW80
NOMESCO Finland
Local dermatologic skincare
15.5
126.1
115
85
L04AX01
ATC
azathioprine; systemic
11.9
115.3
125
122
E0000UV, ,
ATC
5.2
113.8
569
2452
H02AB06
ATC
prednisolone; systemic
5.7
106.4
645
3170
L04AX03
ATC
methotrexate; systemic
6.5
102.8
198
382
L12.8
ICD-10 Finland
Other pemphigoid
+∞
62.3
59
*
L13.9
ICD-10 Finland
Bullous disorder, unspecified
104.0
61.9
67
7
XQ848
NOMESCO Finland
Dermatological photography
7.9
61.3
89
125
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
4.1
59.9
204
616
J04BA02
ATC
dapsone; oral
133.8
58.7
62
5
135
Kela drug reimbursment
Pemphigus
+∞
52.7
50
*
L12
ICD-10 Finland
Pemphigoid
147.1
52.5
55
*
D07AC13
ATC
mometasone; topical
3.0
50.3
339
1547
ECA20
NOMESCO Finland
Biopsy of gingiva
15.1
47.9
43
30
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.8
46.3
452
2482
L29.9
ICD-10 Finland
Pruritus, unspecified
7.4
46.0
69
100
D07AB08
ATC
desonide; topical
3.7
44.8
163
508
D07BC01
ATC
betamethasone and antiseptics; topical
3.6
43.2
172
568
L12.1
ICD-10 Finland
Cicatricial pemphigoid
+∞
41.0
39
*
E000001, ,
ATC
2.9
39.0
230
955
D07AB02
ATC
hydrocortisone butyrate; topical
2.6
36.3
320
1622
A10BH05
ATC
linagliptin; oral
3.8
33.1
113
334
R06AE07
ATC
cetirizine; oral
2.4
31.5
383
2215
S29
ICPC
Skin symptom/complaint other
2.5
29.8
236
1121
A10AB05
ATC
insulin aspart; parenteral
3.4
29.5
121
402
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.3
29.3
81
205
D02AX
ATC
Other emollients and protectives
6.3
28.9
50
84
S97
ICPC
Chronic ulcer skin
3.3
28.2
121
413
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.6
27.9
202
916
D09AB01
ATC
zinc bandage without supplements; topical
6.6
27.2
45
72
L04AA06
ATC
mycophenolic acid; systemic
8.3
27.0
36
45
S99
ICPC
Skin disease other
5.7
26.3
50
92
A02BC02
ATC
pantoprazole; systemic
2.4
25.2
633
4761
L29.8
ICD-10 Finland
Other pruritus
8.0
24.8
34
44
A46
ICD-10 Finland
Erysipelas
2.4
24.4
202
968
A10AE04
ATC
insulin glargine; parenteral
2.8
24.1
137
547
L30.0
ICD-10 Finland
Nummular dermatitis
4.3
23.8
63
154
L30.3
ICD-10 Finland
Infective dermatitis
4.7
23.7
56
125
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
23.0
167
752
T90
ICPC
Diabetes non-insulin dependent
2.2
23.0
283
1598
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.2
22.7
277
1558
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.4
22.6
180
845
J01DB01
ATC
cefalexin; oral
2.6
22.5
697
5574
R06AX27
ATC
desloratadine; oral
2.3
22.5
211
1064
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.5
21.4
160
729
S18
ICPC
Laceration/cut
2.0
21.2
457
3145
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.3
20.8
83
270
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.0
20.1
301
1811
A28
ICPC
Limited function/disability NOS
2.1
19.9
273
1590
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.0
19.4
280
1658
S21
ICPC
Skin texture symptom/complaint
2.3
19.0
164
794
S17
ICPC
Abrasion/scratch/blister
5.0
18.6
41
86
C03CA01
ATC
furosemide; systemic
1.9
18.2
426
2958
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
5.0
18.2
40
84
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.8
17.8
57
160
L13.0
ICD-10 Finland
Dermatitis herpetiformis
+∞
17.8
17
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.0
17.7
83
296
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.8
17.4
97
381
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.7
17.2
101
407
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
4.4
17.1
44
105
A10BA02
ATC
metformin; oral
1.9
16.9
314
2010
103
Kela drug reimbursment
Diabetes, insulin-treated
1.9
16.9
306
1943
L89
ICD-10 Finland
Decubitus ulcer and pressure area
4.4
16.9
43
102
S02
ICPC
Pruritus
3.7
16.5
54
154
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
16.5
485
3579
B86
ICD-10 Finland
Scabies
6.5
16.4
27
43
L30.8
ICD-10 Finland
Other specified dermatitis
4.6
16.0
38
85
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
5.0
15.8
34
70
SAA03
NOMESCO Finland
Extended examination of mouth
1.9
15.6
289
1838
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
4.1
15.6
44
113
EKA10
NOMESCO Finland
iopsy of buccal mucosa
4.7
15.5
36
79
A10AC01
ATC
insulin (human); parenteral
2.5
15.1
102
440
H02AB09
ATC
hydrocortisone; systemic
4.6
14.8
35
78
E000003, ,
ATC
3.5
14.7
52
156
L10.9
ICD-10 Finland
Pemphigus, unspecified
+∞
14.6
14
*
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
14.6
192
1085
SPAT1262
SPAT
Handing over of treatment supplies
2.0
14.4
189
1066
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.4
13.7
105
479
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.9
13.4
212
1273
SPAT1229
SPAT
Assessment of need for aid
2.3
13.3
106
491
D02AE01
ATC
carbamide; topical
2.8
13.3
71
272
L20.0
ICD-10 Finland
Besnier prurigo
3.3
12.8
50
160
ZY010
NOMESCO Finland
Hospital outpatient
3.6
12.8
43
125
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.3
12.7
102
475
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.9
12.2
185
1090
L13.8
ICD-10 Finland
Other specified bullous disorders
38.2
12.2
15
*
E000007, ,
ATC
3.1
12.2
53
181
H02AB07
ATC
prednisone; oral
2.0
12.2
145
787
SPAT1254
SPAT
Administration of medicine
1.9
12.0
167
957
E86
ICD-10 Finland
Volume depletion
3.2
12.0
47
151
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.7
11.8
272
1818
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.7
11.5
326
2301
E000002, ,
ATC
2.3
11.5
90
414
J01FF01
ATC
clindamycin; systemic
1.8
11.5
238
1542
R06AE09
ATC
levocetirizine; oral
2.1
11.1
108
542
S76
ICPC
Skin infection other
2.7
11.1
61
237
D07AA02
ATC
hydrocortisone; topical
2.1
11.0
121
637
E87.5
ICD-10 Finland
Hyperkalaemia
3.6
10.8
36
104
I10
ICD-10 Finland
Essential (primary) hypertension
1.7
10.8
599
4994
M05BA04
ATC
alendronic acid; oral
2.1
10.8
116
606
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
3.3
10.7
40
125
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.0
10.6
133
733
L28.1
ICD-10 Finland
Prurigo nodularis
10.2
10.5
20
20
L12.2
ICD-10 Finland
Chronic bullous disease of childhood
+∞
10.4
10
*
R60.0
ICD-10 Finland
Localized oedema
1.9
10.4
144
821
A10BH02
ATC
vildagliptin; oral
3.5
10.4
35
102
XQ802
NOMESCO Finland
Epicutan test
3.5
10.2
35
103
J01CF05
ATC
flucloxacillin; systemic
2.4
10.1
72
318
G63.2*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy
4.9
10.1
22
46
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
10.1
298
2111
L28
ICPC
Limited function/disability (L)
1.7
9.9
222
1461
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.9
9.9
135
766
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
3.5
9.8
33
96
L50.9
ICD-10 Finland
Urticaria, unspecified
3.5
9.8
34
101
N18.8
ICD-10 Finland
Other chronic renal failure
3.2
9.7
39
127
SBA00
NOMESCO Finland
Microbiological examinations
3.9
9.7
28
73
A04
ICPC
Weakness/tiredness general
1.8
9.5
160
970
SPAT1172
SPAT
Guidance concerning hydration
3.2
9.4
37
119
L10.2
ICD-10 Finland
Pemphigus foliaceus
+∞
9.4
9
*
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.0
9.4
41
141
RS222, ,
NOMESCO Finland
5.0
9.3
20
41
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
3.9
9.3
27
71
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.8
9.3
154
928
A10BH01
ATC
sitagliptin; oral
2.0
9.1
108
583
C03AA03
ATC
hydrochlorothiazide; oral
2.0
9.0
111
607
N02BE01
ATC
paracetamol; systemic, rectal
1.9
8.7
731
6581
R53
ICD-10 Finland
Malaise and fatigue
1.6
8.7
240
1661
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.8
8.6
152
932
XQ845
NOMESCO Finland
Dermatoscopy
3.6
8.6
28
80
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
8.6
264
1873
L03.9
ICD-10 Finland
Cellulitis, unspecified
3.9
8.6
25
66
E11
ICD-10 Finland
Type 2 diabetes mellitus
1.7
8.5
160
998
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
3.3
8.4
32
101
L01.0
ICD-10 Finland
Impetigo [any organism] [any site]
4.7
8.4
19
41
SPAT1216
SPAT
Assessment of functional ability
1.7
8.3
181
1176
E000006, ,
ATC
2.3
8.2
65
301
SPAT1263
SPAT
Sampling
1.5
8.1
342
2599
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.3
8.1
59
263
A98
ICPC
Health maint/preventive medicine
1.9
8.1
738
6699
D01AE15
ATC
terbinafine; topical
2.2
8.0
72
350
K13.78
ICD-10 Finland
Other change in the oral mucosa
3.6
8.0
26
74
AA1AD
NOMESCO Finland
CT of head and brain
1.5
7.8
301
2237
SPAT1234
SPAT
Support of social functional capacity
2.2
7.8
67
320
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
7.8
193
1294
C07AB07
ATC
bisoprolol; oral
1.5
7.8
486
4002
C08CA01
ATC
amlodipine; oral
1.5
7.8
381
2982
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
7.8
295
2187
L10.0
ICD-10 Finland
Pemphigus vulgaris
45.4
7.7
9
*
N18.0
ICD-10 Finland
End-stage renal disease
4.4
7.7
19
44
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
6.8
7.6
18
27
K12.10
ICD-10 Finland
Stomatitis NOS
12.0
7.6
13
11
SPAT1310
SPAT
Counselling related to known health issue
1.6
7.6
249
1785
A10AE05
ATC
insulin detemir; parenteral
2.3
7.4
55
247
NHQ40
NOMESCO Finland
Amputation of toe
3.4
7.4
26
78
L51.19
ICD-10 Finland
Other bullous erythema multiforme
80.8
7.4
8
*
J01MA02
ATC
ciprofloxacin; systemic
1.5
7.4
348
2693
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.7
7.2
167
1099
L50.3
ICD-10 Finland
Dermatographic urticaria
4.5
7.2
17
38
XQ800
NOMESCO Finland
Prick test
2.4
7.2
47
200
QCA99
NOMESCO Finland
Other local destruction of skin of upper limb
30.3
7.2
9
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.6
7.1
174
1163
EBA15
NOMESCO Finland
Extraction of multiple teeth
2.5
7.0
42
171
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.1
7.0
63
307
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.8
7.0
117
704
205
Kela drug reimbursment
Chronic hypertension
1.5
6.9
296
2241
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.0
6.8
77
408
I50.9
ICD-10 Finland
Heart failure, unspecified
1.6
6.8
201
1403
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
6.7
256
1889
SPAT1301
SPAT
No procedures
1.5
6.6
275
2062
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
2.6
6.6
37
146
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.7
6.6
125
779
R03AC02
ATC
salbutamol; inhalant
1.5
6.6
405
3281
A10AE06
ATC
insulin degludec; parenteral
2.8
6.5
32
118
TQW99
NOMESCO Finland
Other minor procedure on skin
2.1
6.5
59
289
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.8
6.5
108
649
SPAT1153
SPAT
Removal of sutures
1.5
6.5
270
2027
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
2.8
6.4
31
113
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.0
6.4
68
353
A10BB12
ATC
glimepiride; oral
1.9
6.3
87
493
SPAT1167
SPAT
Insertion of urinary catheter
2.3
6.3
45
199
L43.9
ICD-10 Finland
Lichen planus, unspecified
3.3
6.3
23
71
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
3.3
6.3
23
71
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.8
6.3
95
554
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
1.9
6.3
87
494
4047, ,
NOMESCO Finland
+∞
6.3
6
*
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
2.3
6.3
47
213
A08
ICPC
Swelling
2.0
6.2
69
364
D64.9
ICD-10 Finland
Anaemia, unspecified
1.7
6.2
126
800
A10BK01
ATC
dapagliflozin; oral
2.0
6.2
71
379
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
6.2
133
857
F03
ICD-10 Finland
Unspecified dementia
2.0
6.2
68
358
J01AA07
ATC
tetracycline; systemic
1.8
6.2
95
558
H25.8
ICD-10 Finland
Other senile cataract
1.6
6.1
135
875
A10BK03
ATC
empagliflozin; oral
1.8
6.1
95
559
WX110
NOMESCO Finland
Infiltration anesthesia
1.4
6.1
497
4218
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
2.6
6.1
33
128
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
6.1
268
2028
J45
ICD-10 Finland
Asthma
1.9
6.1
79
440
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.6
6.0
171
1178
F01.9
ICD-10 Finland
Vascular dementia, unspecified
2.8
6.0
29
106

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
485
53
219.12
307.65
3.2
1.2
33.80
15.40
u/ml
—
287
5
346
47
125.64
307.65
1.8
1.1
49.52
58.33
titre
—
21
6
279
327
12.35
233.42
1.4
1.2
—
—
—
0
0
219
676
4.04
62.54
2.9
2.0
348.14
392.11
nmol/l
2.48
202
619
601
3608
3.42
56.33
10.8
5.5
0.65
0.62
e9/l
1.80
558
3038
601
3623
3.40
55.61
10.8
5.5
0.04
0.04
e9/l
0.36
558
3058
604
3672
3.38
54.66
10.9
5.6
1.63
1.83
e9/l
3.55
563
3188
140
343
4.71
53.78
1.5
1.2
605.13
173.89
u/ml
4.33
133
314
606
3711
3.35
53.75
11.2
5.7
0.23
0.20
e9/l
3.98
566
3185
562
3338
3.12
51.70
11.1
5.8
3.24
2.81
%
3.05
547
3109
562
3343
3.11
51.46
11.4
5.9
8.86
9.12
%
1.43
547
3116
465
2496
2.97
51.41
10.9
5.5
—
—
—
0
0
563
3388
3.06
49.78
11.3
5.8
23.07
25.45
%
5.53
552
3192
557
3337
3.04
49.56
11.2
5.8
0.63
0.64
%
0.24
541
3107
555
3324
3.03
49.31
11.0
5.7
61.40
59.12
%
4.41
545
3157
622
4056
3.14
45.66
12.3
8.9
4.67
4.36
e9/l
2.52
570
3493
225
892
3.09
41.76
2.1
1.8
—
—
—
0
0
523
3654
2.17
24.78
5.4
5.1
33.30
34.60
g/l
5.33
488
3413
371
2287
2.13
24.28
2.8
2.4
2.89
3.03
mg/l
0.38
330
1958
173
797
2.48
22.65
1.5
2.9
65.49
65.94
g/l
0.33
161
726
248
1345
2.20
22.17
1.3
1.2
0.96
1.32
u/ml
0.79
68
312
148
659
2.52
20.71
1.5
2.7
—
—
—
0
0
680
5451
2.38
20.59
9.6
8.3
84.00
82.57
u/l
0.19
656
5119
216
1153
2.18
19.79
2.9
2.5
1.99
1.78
%
1.98
200
1033
552
4132
2.01
19.28
8.1
7.3
1.20
1.21
mmol/l
0.82
479
3537
535
4013
1.94
17.94
6.3
6.4
12.52
12.40
umol/l
0.05
505
3826
176
900
2.21
17.75
3.1
2.6
75.48
67.24
e9/l
1.52
131
679
255
1505
2.00
17.56
3.0
2.7
11.06
11.93
umol/l
1.34
243
1390
439
3108
1.88
17.37
16.8
12.4
0.00
0.00
e9/l
0.65
365
2527
381
2586
1.88
17.15
5.3
4.4
—
—
—
0
0
326
2115
1.89
16.81
9.6
6.2
—
—
—
0
0
28
21
13.76
16.56
1.5
1.1
9.16
9.49
ug/l
0.12
28
21
167
863
2.17
16.30
1.5
1.4
—
—
—
0
0
577
4519
1.91
16.01
6.1
5.3
7.49
6.86
mmol/l
5.98
553
4320
499
3741
1.84
15.82
7.6
6.5
1.20
1.21
mmol/l
0.65
458
3427
486
3640
1.81
15.19
2.6
2.3
94.75
94.57
pmol/l
0.03
279
1911
157
818
2.13
14.90
1.5
1.3
367.62
436.78
titre
0.36
42
199
386
2714
1.79
14.81
4.3
3.8
—
—
—
0
0
440
3217
1.78
14.75
2.9
2.4
79.88
79.48
nmol/l
0.09
394
2824
369
2567
1.79
14.63
2.0
1.8
18.77
20.13
nmol/l
1.05
322
2145
220
1312
1.92
14.27
3.0
2.7
20.42
21.73
%
0.71
206
1217
434
3191
1.76
13.99
3.7
3.1
142.26
149.75
ug/l
0.29
405
2907
152
801
2.10
13.95
5.8
6.4
12.82
11.43
mmol/l
1.23
145
764
229
1405
1.87
13.51
3.0
2.6
2.21
2.23
g/l
0.23
214
1289
602
4922
1.81
12.88
6.8
5.6
8340.18
2986.72
e6/l
0.60
11
93
232
1450
1.83
12.80
6.9
4.6
—
—
—
0
0
151
826
2.01
12.43
4.3
2.8
5.57
5.42
e9/l
0.06
125
697
260
1703
1.77
12.17
2.0
1.8
1270.64
1206.82
nmol/l
0.44
194
1287
734
6461
2.19
11.87
30.6
20.3
27.11
27.63
mg/l
0.19
670
5559
198
1205
1.84
11.79
3.0
2.0
—
—
—
0
0
595
4927
1.74
11.27
5.9
5.2
—
2.47
—
0
12
162
937
1.91
11.26
3.7
3.5
7.36
7.38
ph
1.21
88
574
195
1201
1.82
11.09
1.5
1.5
3.01
2.69
g/l
1.08
121
680
142
790
1.96
11.06
2.0
2.1
0.20
0.20
g/l
0.06
129
734
393
2934
1.65
11.02
3.8
3.5
2084.96
1835.11
ng/l
0.40
339
2593
141
785
1.96
10.96
3.0
2.9
4.39
4.39
kpa
0.00
135
759
78
346
2.38
10.80
1.4
2.6
9.74
10.80
g/l
1.77
72
305
703
6149
1.94
10.70
9.0
7.4
43.23
40.47
mmol/mol
8.86
661
5631
160
939
1.87
10.58
3.7
3.5
5.93
5.81
kpa
0.73
155
909
187
1152
1.80
10.58
5.7
5.2
1.05
1.03
mmol/l
0.37
169
1066
748
6709
2.18
10.29
36.4
25.2
138.78
139.51
mmol/l
9.15
738
6572
155
910
1.87
10.22
3.8
3.5
1.43
1.98
mmol/l
0.86
141
764
748
6714
2.17
10.19
36.5
25.4
4.02
4.02
mmol/l
0.23
737
6568
142
815
1.90
10.03
5.3
6.8
1.57
1.40
mmol/l
1.21
137
802
502
4038
1.62
10.00
21.9
20.3
1.40
1.37
inr
0.47
430
3430
147
860
1.86
9.77
2.4
2.7
8.84
9.23
umol/l
0.06
131
763
117
635
1.98
9.74
1.6
1.5
—
—
—
0
0
477
3809
1.59
9.64
4.8
4.6
0.00
4.02
estimate
0.80
96
871
707
6258
1.88
9.49
6.1
5.7
6.33
6.11
mmol/l
3.33
653
5600
591
4984
1.65
9.40
4.6
4.2
15.33
15.14
pmol/l
1.00
542
4458
209
1371
1.70
9.37
2.7
3.0
0.81
0.82
mmol/l
0.26
190
1282
470
3760
1.58
9.26
4.8
4.6
0.00
0.00
estimate
-0.00
89
843
750
6786
2.10
9.23
42.1
27.5
93.73
85.45
umol/l
3.48
743
6689
103
545
2.02
9.19
1.5
1.5
—
—
—
0
0
411
3196
1.57
9.12
5.3
4.6
159.28
74.31
ng/l
0.32
352
2567
336
2498
1.58
9.05
2.5
2.2
178.35
237.15
u/l
0.89
315
2349
740
6676
2.01
8.99
19.9
13.0
23.96
24.07
u/l
0.06
724
6448
393
3033
1.56
8.96
4.0
4.0
6.25
6.27
ph
0.11
204
1673
174
1099
1.74
8.90
5.5
6.8
0.63
1.10
mmol/l
0.66
136
909
681
5993
1.76
8.88
6.0
5.4
2.11
2.04
mu/l
0.53
631
5396
174
1103
1.73
8.77
5.7
6.9
7.43
7.42
ph
1.05
99
653
475
3836
1.56
8.77
4.9
4.6
0.01
0.38
estimate
0.49
84
817
353
2672
1.56
8.69
4.6
4.1
16.71
9.28
mg/mmol
0.78
256
1705
348
2627
1.56
8.67
3.8
3.3
6.62
7.07
mmol/l
1.34
293
2163
125
726
1.85
8.45
1.6
1.6
—
—
—
0
0
43
161
2.76
8.44
1.3
1.2
11.67
2.92
u/ml
—
6
17
322
2401
1.56
8.40
3.3
2.5
57.56
94.44
u/l
0.57
290
2223
344
2605
1.55
8.37
3.8
3.4
74.19
54.34
mg/l
0.75
251
1712
750
6831
2.03
8.35
46.6
30.5
92.43
91.92
fl
2.00
741
6735
43
162
2.74
8.34
1.3
1.3
10.73
2.42
u/ml
—
6
25
57
247
2.40
8.33
1.6
1.6
3.19
8.35
iu/ml
1.62
11
62
750
6833
2.02
8.32
46.7
30.6
245.35
238.66
e9/l
1.76
739
6672
750
6833
2.02
8.32
46.7
30.6
4.22
4.35
e12/l
8.83
739
6643
750
6833
2.02
8.32
47.2
31.1
38.57
39.24
%
3.31
741
6732
750
6833
2.02
8.32
46.5
30.5
30.48
30.45
pg
0.16
741
6735
750
6834
2.02
8.30
46.8
30.6
7.49
6.96
e9/l
7.60
738
6647
750
6834
2.02
8.30
47.1
30.8
127.06
131.21
g/l
10.90
742
6738
172
1107
1.70
8.16
5.7
6.8
5.05
5.10
kpa
0.28
161
1068
172
1108
1.70
8.13
5.7
6.8
11.84
11.67
kpa
0.12
161
1069
335
2540
1.54
8.01
5.2
4.2
7.40
7.40
ph
0.53
248
1839
35
121
2.98
7.94
1.2
1.1
34.32
53.51
u/ml
—
6
14
482
3973
1.51
7.61
3.9
3.3
68.21
56.36
u/l
1.12
445
3662
102
575
1.88
7.55
4.4
3.9
5.31
5.18
kpa
0.66
96
556
717
6485
1.78
7.48
27.9
18.6
—
—
—
0
0
362
2828
1.50
7.33
3.2
3.5
2.34
2.35
mmol/l
0.35
326
2540
100
567
1.87
7.27
4.4
3.9
7.41
7.41
ph
0.11
81
484
153
992
1.67
6.99
5.8
7.0
95.98
95.09
%
1.17
147
964
114
686
1.77
6.82
5.5
4.0
0.94
0.89
%
0.09
42
233
246
1795
1.53
6.79
2.1
1.8
453.48
6694718.85
pmol/l
0.79
203
1449
108
643
1.78
6.70
4.7
4.0
0.54
0.66
%
0.35
41
208
342
2680
1.47
6.62
2.5
2.4
—
—
—
0
0
42
177
2.45
6.55
1.5
1.3
55.23
59.25
mmol/l
0.25
35
146
123
770
1.70
6.39
6.7
8.0
—
—
—
0
0
697
6328
1.64
6.27
6.1
6.3
2.38
2.49
mmol/l
2.52
639
5709
216
1559
1.52
6.20
1.6
1.7
1.34
1.58
mg/l
0.92
171
1247
81
452
1.88
6.19
1.4
2.0
1.61
1.55
g/l
0.22
72
405
106
644
1.74
6.12
5.0
4.1
0.17
0.12
%
0.19
36
191
22
68
3.30
6.04
1.5
1.5
16.83
43.45
ng/l
0.89
22
68
238
1768
1.49
5.91
4.1
4.3
—
0.16
—
0
31
46
212
2.24
5.89
3.4
3.6
1.39
1.85
index
0.38
23
110
343
2743
1.43
5.73
4.4
3.8
331.55
109.85
e6/l
0.38
270
2171
63
332
1.97
5.71
2.0
2.1
362.36
532.28
ug/l
0.43
58
316
369
2992
1.42
5.70
5.2
4.5
206.08
122.69
e6/l
0.75
270
2230
46
216
2.20
5.64
1.1
1.7
—
—
—
0
0
283
2192
1.44
5.61
2.9
3.1
34.01
35.38
u/l
0.14
265
2059
54
272
2.05
5.55
1.3
1.3
—
—
—
0
0
107
673
1.68
5.45
3.9
3.9
130.78
94.19
ng/l
1.83
91
578
32
132
2.48
5.27
4.8
4.3
0.73
1.58
%
1.32
26
118
62
335
1.92
5.24
1.4
3.8
47.69
71.69
mg/l
0.63
50
283
62
337
1.91
5.15
1.4
3.8
29.07
65.54
mg/l
2.18
50
288
185
1339
1.49
5.14
1.8
1.9
29.30
29.84
s
0.65
180
1302
675
6174
1.50
4.90
5.3
5.4
4.30
4.38
mmol/l
1.06
612
5602
296
2364
1.39
4.77
4.3
3.6
0.54
0.54
e6/l
0.01
226
1810
90
562
1.67
4.72
6.3
8.6
23.75
24.42
mmol/l
1.11
84
547
32
141
2.32
4.60
4.0
2.9
10.31
9.68
pmol/l
0.16
32
141
668
6120
1.47
4.59
5.1
5.3
1.44
1.44
mmol/l
0.12
601
5499
76
457
1.73
4.57
1.3
1.2
—
—
—
0
0
23
87
2.69
4.52
7.4
4.0
61.24
55.92
%
0.51
17
76
28
118
2.42
4.44
3.0
2.5
5.36
4.75
e9/l
0.59
28
118
218
1670
1.41
4.43
5.8
4.5
191.63
323.96
ng/l
0.79
197
1465
100
658
1.59
4.27
5.4
4.4
0.38
0.16
%
0.24
32
183
42
215
2.00
4.18
3.2
2.2
125.76
128.17
g/l
0.35
37
168
222
1725
1.39
4.12
3.7
3.2
510.82
534.73
mosm/kgh2o
1.20
199
1513
39
197
2.03
4.04
4.2
2.7
89.09
88.41
%
0.29
39
190
66
396
1.72
4.02
4.0
4.1
—
—
—
0
0
70
429
1.69
3.96
1.7
1.8
1.14
1.53
g/l
1.15
65
390
54
309
1.80
3.87
1.3
3.6
1.53
2.65
ratio
2.01
27
186
42
223
1.93
3.80
1.9
2.7
1.94
1.76
mg/l
0.72
36
193
61
365
1.72
3.77
1.2
1.3
—
—
—
0
0
82
532
1.60
3.72
2.3
2.8
10.63
11.27
g/l
0.62
77
486
55
321
1.76
3.70
1.5
1.4
—
14.00
—
0
6
46
255
1.85
3.66
4.9
5.8
1.20
1.32
mmol/l
0.49
41
227
67
417
1.66
3.59
2.5
2.6
—
—
—
0
0
15
51
2.98
3.59
1.6
1.2
—
—
—
0
0
192
1488
1.38
3.57
3.5
3.3
1.34
1.05
e6/l
0.48
98
841
269
2196
1.33
3.57
5.0
4.6
0.00
0.01
estimate
0.78
81
748
181
1392
1.38
3.52
3.7
3.5
3.31
2.01
e6/l
0.78
89
740
56
334
1.73
3.51
2.0
2.4
0.00
0.01
estimate
0.50
13
97
22
94
2.38
3.43
1.2
1.3
271.13
271.72
mosm/kgh2o
0.03
15
64
66
415
1.64
3.41
2.4
1.7
1.12
3.35
ug/l
1.09
54
360
335
2838
1.30
3.37
5.2
4.7
0.00
0.07
estimate
1.15
75
702
113
808
1.46
3.30
2.4
2.6
5.20
6.58
ug/l
0.50
90
708
48
280
1.76
3.27
4.7
2.7
326.25
522.35
mg/l
0.38
28
109
30
152
2.01
3.13
3.1
2.5
63.17
61.05
%
0.47
30
152
225
1822
1.32
3.10
3.5
3.1
2.49
2.47
mmol/l
2.03
203
1631
41
232
1.81
3.10
4.1
2.8
7.78
7.80
kpa
0.04
41
227
19
80
2.41
3.08
1.4
1.3
—
—
—
0
0
13
41
3.20
3.06
1.0
1.1
—
—
—
0
0
632
5860
1.33
3.05
4.4
4.5
1.30
1.25
mmol/l
1.14
561
5205
97
685
1.47
3.02
2.2
2.3
0.00
0.02
estimate
0.50
15
131
48
292
1.68
2.85
4.6
4.7
24.82
25.14
mmol/l
0.32
43
270
239
1972
1.30
2.84
3.6
2.9
6.07
4.82
e6/l
0.76
222
1807
237
1961
1.29
2.75
3.5
3.0
375.71
360.70
umol/l
1.12
206
1668
387
3401
1.26
2.73
3.3
2.9
—
—
estimate
—
0
0
8
19
4.24
2.68
1.0
1.0
1442.25
1717.26
miu/ml
—
8
19
8
19
4.24
2.68
1.3
1.2
—
—
—
0
0
35
198
1.80
2.68
5.8
4.0
—
—
—
0
0
20
93
2.18
2.62
1.6
1.5
76.00
66.45
%
0.58
15
65
22
107
2.08
2.59
1.5
1.1
—
—
—
0
0
6
11
5.49
2.54
1.0
1.0
—
—
—
0
0
10
31
3.25
2.52
1.0
1.1
—
—
—
0
0
21
102
2.09
2.49
2.2
2.4
0.72
1.31
g/24h
0.96
13
57
80
567
1.45
2.48
3.4
3.4
6.03
6.07
ph
0.14
61
412
96
705
1.41
2.45
3.2
2.5
47.72
34.20
u/l
0.37
83
593
14
58
2.44
2.38
1.1
1.2
95.57
95.52
pmol/l
0.00
14
58
25
133
1.91
2.33
1.1
1.3
0.92
0.87
nmol/l
0.15
19
109
31
177
1.78
2.33
1.4
2.8
28.62
35.64
umol/l
1.02
26
152
203
1685
1.27
2.26
5.4
4.9
1.02
1.02
kg/l
1.35
147
1168
5
9
5.58
2.21
1.2
1.3
—
—
—
0
0
63
442
1.46
2.08
3.5
3.2
25.61
25.26
mmol/l
0.35
63
424
105
809
1.34
2.03
4.1
3.4
225.00
253.87
ng/l
0.35
94
749
21
112
1.90
1.97
1.3
1.3
—
—
—
0
0
287
2509
1.22
1.97
3.0
2.6
—
—
—
0
0
25
142
1.78
1.94
1.5
1.5
—
10.68
—
0
5
20
106
1.91
1.92
1.0
1.1
—
—
—
0
0
18
92
1.98
1.91
1.4
1.3
186.00
157.91
au/ml
—
5
29
326
2895
1.21
1.89
5.3
6.3
2.31
3.50
ug/l
1.93
296
2567
24
138
1.76
1.81
1.2
1.2
—
—
—
0
0
9
35
2.59
1.80
1.0
1.0
—
—
—
0
0
41
273
1.53
1.77
3.9
3.7
0.79
0.84
nmol/l
0.41
32
227
17
88
1.95
1.76
3.8
4.3
—
—
—
0
0
8
30
2.68
1.72
1.0
1.0
—
—
—
0
0
11
48
2.31
1.71
1.1
1.1
—
—
—
0
0
17
89
1.93
1.71
1.1
1.0
—
—
—
0
0
33
211
1.59
1.70
1.2
1.4
0.25
0.32
mg/l
0.37
16
91
89
689
1.33
1.69
5.5
3.7
1.22
1.22
mmol/l
0.04
82
584
96
752
1.31
1.68
5.0
4.7
7.36
7.35
ph
0.14
68
540
6
19
3.17
1.66
1.8
1.1
—
—
—
0
0
90
704
1.31
1.60
2.0
2.1
208.30
156.49
ug/g
0.34
72
550
18
100
1.82
1.54
1.2
1.2
214.77
295.79
u/ml
0.62
13
48
11
51
2.17
1.51
1.1
1.1
—
—
—
0
0
217
1891
1.20
1.50
2.9
2.5
—
—
—
0
0
15
81
1.87
1.40
1.1
2.3
526.33
958.74
mg
0.85
15
81
12
60
2.01
1.38
2.7
2.7
—
—
—
0
0
16
89
1.81
1.38
1.1
1.1
—
—
—
0
0
53
394
1.37
1.34
2.2
2.5
—
19.09
—
0
24
224
1985
1.18
1.27
4.9
4.1
0.01
0.06
estimate
0.58
74
656
10
49
2.05
1.22
1.1
1.8
714.00
1069.52
e6/l
—
5
44
5
19
2.64
1.21
1.4
1.2
—
—
—
0
0
15
86
1.76
1.19
2.4
1.9
—
—
—
0
0
8
38
2.12
1.18
1.1
1.6
40.84
38.57
%
—
8
38
90
740
1.24
1.12
2.8
2.7
0.41
0.71
e6/l
0.94
85
713
14
81
1.74
1.09
1.4
1.6
9.31
10.31
%
0.37
14
81
28
194
1.46
1.08
1.1
1.2
—
—
—
0
0
114
967
1.21
1.06
1.2
1.3
—
—
—
0
0
30
212
1.43
1.05
12.0
12.9
—
—
—
0
0
23
155
1.50
1.02
1.7
1.7
1.95
40.50
iu/l
—
6
64
14
83
1.70
1.02
1.1
1.2
—
—
—
0
0
5
23
2.18
0.98
1.2
2.7
—
—
—
0
0
24
166
1.46
0.95
1.1
1.2
—
—
—
0
0
111
951
1.19
0.95
1.4
1.4
—
—
—
0
0
9
51
1.77
0.94
1.0
1.1
—
—
—
0
0
18
118
1.54
0.91
1.8
1.5
6.35
6.56
mmol/l
0.13
18
113
17
110
1.56
0.91
1.9
2.2
11.18
10.45
mmol/l
0.33
17
110
49
386
1.29
0.90
1.9
2.1
—
—
—
0
0
22
152
1.46
0.88
1.8
1.4
1035.88
1372.14
e6/l
0.28
16
101
12
193
0.62
0.88
1.1
1.2
—
—
—
0
0
26
186
1.41
0.88
6.7
4.8
3.40
2.72
mmol/l
0.41
18
126
10
57
1.76
0.84
1.0
1.8
—
—
—
0
0
0
24
0.00
0.79
0.0
1.3
—
90.60
—
0
17
15
98
1.54
0.79
1.1
1.4
—
—
—
0
0
15
98
1.54
0.79
1.1
1.4
—
—
—
0
0
15
98
1.54
0.79
1.1
1.4
—
—
—
0
0
15
98
1.54
0.79
1.1
1.4
—
—
—
0
0
5
99
0.50
0.78
2.0
1.2
1.37
1.57
g/l
—
5
99
7
125
0.56
0.78
3.7
2.4
—
—
—
0
0
0
27
0.00
0.77
0.0
1.1
—
287.94
—
0
16
6
34
1.77
0.76
1.2
1.9
40.75
39.23
g/l
—
6
34
48
589
0.80
0.75
1.5
1.5
—
—
—
0
0
6
107
0.56
0.73
1.8
1.2
0.66
0.89
g/l
—
6
107
5
25
2.01
0.72
1.0
1.6
2.56
9.54
nmol/l
—
5
19
14
92
1.53
0.72
1.3
2.1
—
—
—
0
0
13
85
1.54
0.69
2.2
2.6
—
—
—
0
0
30
232
1.30
0.67
1.3
1.4
296.64
262.87
ug/g
0.38
11
139
5
28
1.79
0.66
1.8
1.1
—
—
—
0
0
5
28
1.79
0.66
1.8
1.1
—
—
—
0
0
5
28
1.79
0.66
1.8
1.1
—
—
—
0
0
18
129
1.40
0.64
1.6
1.6
—
—
—
0
0
21
155
1.36
0.63
1.5
2.2
0.90
0.83
%
0.23
13
113
5
30
1.67
0.61
2.6
2.6
1015.60
1568.10
u/ml
—
5
30
291
2740
1.10
0.61
4.5
4.2
—
0.79
—
0
14
119
1077
1.12
0.54
1.4
1.3
31.04
35.56
iu/ml
0.15
34
333
89
792
1.14
0.52
1.4
1.3
—
—
—
0
0
40
334
1.21
0.51
3.8
3.2
3.89
4.36
pmol/l
2.09
32
293
21
162
1.30
0.50
2.3
1.5
—
—
—
0
0
59
515
1.16
0.46
1.7
2.5
10.94
12.36
nmol/l
0.68
48
443
13
94
1.39
0.46
1.2
1.1
—
—
—
0
0
17
130
1.31
0.44
1.0
1.1
—
—
—
0
0
28
339
0.82
0.43
2.8
3.3
27.02
1350.35
u/ml
1.80
28
289
8
56
1.43
0.42
1.3
1.2
—
—
—
0
0
39
332
1.18
0.42
1.5
1.2
—
—
—
0
0
24
194
1.24
0.42
1.8
2.5
88.13
91.77
ug/min
0.03
12
117
5
34
1.47
0.40
1.2
1.0
—
—
—
0
0
8
60
1.34
0.40
1.1
1.2
—
—
—
0
0
23
280
0.82
0.39
2.7
3.5
179.00
123.46
u/ml
0.13
23
270
9
67
1.35
0.38
1.0
1.2
—
—
—
0
0
9
68
1.33
0.37
1.4
1.2
—
—
—
0
0
16
125
1.29
0.37
1.6
1.4
—
—
—
0
0
16
126
1.28
0.35
1.8
1.3
—
—
—
0
0
46
405
1.14
0.35
2.7
3.0
—
—
—
0
0
61
549
1.12
0.34
1.6
1.6
—
—
—
0
0
15
119
1.27
0.32
1.3
1.2
—
—
—
0
0
12
92
1.31
0.32
3.1
5.0
253.43
351.96
umol/l
—
7
83
7
52
1.35
0.31
1.9
2.0
199.57
104.77
ng/l
—
7
52
99
919
1.09
0.31
3.7
4.1
4.12
22.75
ug/l
1.47
76
779
26
222
1.18
0.29
1.4
1.6
15818.33
17919.25
e6/l
0.14
18
157
107
1002
1.08
0.28
1.3
1.3
3.97
12.66
u/ml
1.95
43
338
8
66
1.21
0.26
2.0
2.7
15.71
15.99
%
—
8
66
12
95
1.27
0.26
1.3
1.7
284.67
281.89
mu/l
0.01
12
89
5
72
0.69
0.26
1.0
1.2
—
—
—
0
0
5
72
0.69
0.26
1.0
1.2
—
—
—
0
0
15
124
1.21
0.24
1.5
1.7
—
—
—
0
0
19
222
0.85
0.23
1.7
1.8
3.26
3.46
mmol/l
0.36
14
172
5
38
1.32
0.23
1.2
1.1
42.40
44.77
mg/l
—
5
31
70
652
1.08
0.22
1.6
1.4
—
—
—
0
0
176
1691
1.05
0.22
3.1
3.6
1.13
0.83
ug/l
0.69
124
1190
5
41
1.22
0.22
1.0
1.4
98.00
65.61
mg/l
—
5
31
0
10
0.00
0.21
0.0
2.5
—
19.03
—
0
10
20
230
0.87
0.21
1.5
1.4
—
—
—
0
0
28
249
1.13
0.21
3.2
3.4
1.87
1.65
mmol/l
0.48
28
243
6
48
1.25
0.20
1.3
1.2
—
—
—
0
0
6
48
1.25
0.20
2.2
1.9
—
—
—
0
0
6
49
1.23
0.20
2.7
2.4
—
53.78
—
0
8
27
241
1.12
0.19
1.6
1.5
—
—
—
0
0
10
81
1.24
0.19
1.1
1.4
6880.00
181027.63
e6/l
—
5
54
65
610
1.07
0.18
5.8
4.1
—
—
—
0
0
7
62
1.13
0.17
1.1
1.2
—
—
—
0
0
5
70
0.71
0.16
1.0
1.2
—
—
—
0
0
29
266
1.09
0.14
1.3
1.3
—
—
—
0
0
15
132
1.14
0.13
1.5
1.4
28896.33
88068.11
e6/l
—
6
72
12
105
1.14
0.11
1.8
1.7
—
—
—
0
0
13
115
1.13
0.10
3.7
1.8
88.13
89.25
%
0.51
13
115
170
1732
0.98
0.08
1.4
1.3
—
—
—
0
0
7
64
1.09
0.08
1.3
1.1
—
—
—
0
0
7
67
1.05
0.08
1.0
1.3
—
—
—
0
0
6
70
0.86
0.07
1.0
1.2
—
—
—
0
0
6
72
0.83
0.07
1.0
1.2
—
—
—
0
0
8
74
1.08
0.07
2.0
2.7
7.22
7.87
mmol/l
—
8
74
197
1940
1.02
0.07
3.4
3.6
—
—
—
0
0
7
83
0.84
0.07
1.4
1.3
—
—
nmol/l
—
0
0
42
403
1.04
0.07
1.1
1.3
—
—
—
0
0
16
171
0.93
0.05
5.0
4.1
33.05
29.24
mg/l
0.14
11
124
20
189
1.06
0.04
1.1
1.1
—
—
—
0
0
12
129
0.93
0.03
3.1
2.9
—
—
—
0
0
22
211
1.04
0.03
3.5
3.6
8.82
7.66
mmol/l
0.70
22
205
258
2595
0.99
0.02
2.1
1.9
1.29
1.27
mmol/l
0.16
224
2105
25
244
1.03
0.00
5.3
5.6
—
—
—
0
0
14
144
0.97
0.00
1.4
1.4
—
—
—
0
0
17
166
1.02
0.00
1.3
1.1
—
—
—
0
0
31
314
0.99
0.00
1.2
1.2
149.08
131.94
u/ml
0.05
12
113
10
97
1.03
0.00
1.3
1.3
—
0.61
—
0
7
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.7
—
5.42
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
-0.00
2.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
98
0.92
-0.00
1.8
1.3
—
—
—
0
0
5
59
0.85
-0.00
1.4
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
72
0.97
-0.00
1.0
1.1
—
—
—
0
0
5
52
0.96
-0.00
3.0
2.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
68.57
—
0
7
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
58
0.86
-0.00
1.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint L12_PEMPHIGOID_BULL and mortality.

Females

Parameter HR [95% CI] p-value
L12_PEMPHIGOID_BULL 1.818 [1.56, 2.12] < 0.001
Birth year 0.992 [0.98, 1.0] 0.081

During the follow-up period (1.1.1998 — 31.12.2019), 1650 out of 3117 females with L12_PEMPHIGOID_BULL died.

Males

Parameter HR [95% CI] p-value
L12_PEMPHIGOID_BULL 1.918 [1.57, 2.35] < 0.001
Birth year 0.991 [0.98, 1.0] 0.051

During the follow-up period (1.1.1998 — 31.12.2019), 1263 out of 2311 males with L12_PEMPHIGOID_BULL died.

Mortality risk

Mortality risk for people of age

years, who have L12_PEMPHIGOID_BULL.

N-year risk Females Males
1 0.151% 0.439%
5 0.984% 2.339%
10 2.302% 6.252%
15 4.504% 11.913%
20 7.97% 19.969%

Relationships between endpoints

Index endpoint: L12_PEMPHIGOID_BULL – Bullous pemphigoid

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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