Other acantholytic disorders

L12_ACANTHOLYTIC

liver disease: A disease involving the liver.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L11 Cause of death: ICD-10 — L11 2 out of 7 registries used, show all original rules.	107
4. Check minimum number of events None	107
5. Include endpoints L12_KERATFOLL L12_GROVER L12_ACANTHNAS	107
6. Filter based on genotype QC (FinnGen only)	98

Control definitions (FinnGen only)

Control exclude: L12_BULLOUS

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L10-L14
Name in latin: Aliae morbositates acantholyticae

NAME	L12_ACANTHOLYTIC
CONTROL_EXCLUDE	L12_BULLOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	L12_KERATFOLL\|L12_GROVER\|L12_ACANTHNAS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L11
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L11
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other acantholytic disorders based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	473	161	310
Only index persons	425	134	291
Unadjusted period prevalence (%)
Whole population	0.01	0.00	0.01
Only index persons	0.01	0.00	0.01
Median age at first event (years)
Whole population	71.40	69.04	72.62
Only index persons	70.72	67.25	72.32

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	98	35	63
Unadjusted period prevalence (%)	0.02	0.01	0.03
Median age at first event (years)	70.74	67.30	72.65

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
101: Matched controls
1010

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L11.1

ICD-10 Finland

Transient acantholytic dermatosis [Grover]

+∞

90.8

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

10.6

28.3

L30.9

ICD-10 Finland

Dermatitis, unspecified

7.9

24.4

115

E0000UV, ,

ATC

6.9

19.6

259

L11.0

ICD-10 Finland

Acquired keratosis follicularis

+∞

17.2

D07BB04

ATC

hydrocortisone butyrate and antiseptics; topical

6.9

17.1

D05BB02

ATC

acitretin; oral

26.6

16.9

D07AC01

ATC

betamethasone; topical

4.6

13.3

235

L11.9

ICD-10 Finland

Acantholytic disorder, unspecified

+∞

12.8

D07AC13

ATC

mometasone; topical

4.1

11.0

177

D07AD01

ATC

clobetasol; topical

4.8

10.8

L82

ICD-10 Finland

Seborrhoeic keratosis

3.6

8.2

140

D07AB08

ATC

desonide; topical

4.5

8.2

D07AB02

ATC

hydrocortisone butyrate; topical

3.3

7.9

190

XQ845

NOMESCO Finland

Dermatoscopy

20.3

7.8

WXQ27

NOMESCO Finland

UVB narrow spectrum light therapy

+∞

7.4

R21

ICD-10 Finland

Rash and other nonspecific skin eruption

7.4

7.0

L29.8

ICD-10 Finland

Other pruritus

43.0

6.9

XQ848

NOMESCO Finland

Dermatological photography

13.5

6.8

S02

ICPC

Pruritus

9.6

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40768443) Skin Pathology biopsy report

14.14

31.27

1.7

1.1

—

(40768804) Tissue Pathology biopsy report

351

2.53

4.96

3.2

2.3

—

(40768797) Stomach Pathology biopsy report

125

2.85

4.92

1.4

1.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

165

2.60

4.56

1.6

1.4

2.35

2.49

g/l

0.18

(3019198) Lymphocytes [#/volume] in Blood

468

2.50

4.40

9.8

5.7

2.25

1.74

e9/l

0.54

404

(3002256) Pathology report gross observation

115

2.70

4.15

1.5

1.2

—

(3001604) Monocytes [#/volume] in Blood

463

2.33

3.89

9.9

5.7

0.65

0.63

e9/l

0.19

389

(3006315) Basophils [#/volume] in Blood

464

2.32

3.85

9.9

5.7

0.04

e9/l

0.45

388

(3005719) IgG [Mass/volume] in Serum or Plasma

3.00

3.81

1.7

2.0

9.84

10.03

g/l

0.08

(42870588) Differential panel, method unspecified - Blood

319

2.21

3.73

8.7

5.4

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

411

2.22

3.69

4.8

3.1

168.36

159.13

ug/l

0.06

380

(3013115) Eosinophils [#/volume] in Blood

479

2.28

3.68

9.9

6.1

0.20

e9/l

0.06

406

(3004588) Protein electrophoresis panel - Serum or Plasma

2.79

3.66

1.3

2.2

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

153

2.37

3.53

5.2

6.6

1.03

1.05

mmol/l

0.11

143

(40760888) Immunoglobulin light chains.free panel - Serum

5.38

3.46

1.3

3.7

—

(3004616) Nuclear Ab [Presence] in Serum

7.42

3.42

1.1

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

4.70

3.41

1.4

1.3

0.26

0.25

g/l

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

4.70

3.41

1.4

1.3

1.18

1.21

g/l

—

(3037522) Nuclear Ab [Titer] in Serum

112

2.50

3.41

1.3

194.29

393.85

titre

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

179

2.25

3.35

1.5

1.3

0.61

1.40

u/ml

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

329

2.11

3.35

2.5

2.1

1.07

1.32

mmol/l

2.39

273

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

441

2.14

3.33

2.8

2.3

104.44

92.15

pmol/l

0.58

246

(3022145) Colonoscopy Study observation

103

2.45

3.09

1.6

1.3

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

388

1.99

2.90

3.1

2.6

88.85

76.61

nmol/l

1.77

346

(3032080) INR in Blood by Coagulation assay

487

2.03

2.83

19.3

17.4

1.50

1.34

inr

0.97

410

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

3.40

2.74

1.4

2.8

3.76

5.49

ratio

—

(3038026) Centromere Ab [Units/volume] in Serum

6.30

2.74

1.0

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

272

1.93

2.57

5.1

2.2

2.27

2.82

mg/l

1.36

239

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

3.70

2.55

1.2

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

513

1.91

2.40

11.9

9.4

3.80

4.49

e9/l

2.22

442

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

832

2.87

2.33

24.6

19.4

23.53

27.67

mg/l

0.81

717

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.50

2.26

1.1

1.3

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

4.48

2.18

1.0

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

199

1.89

2.16

4.4

1.7

0.81

1.35

mg/l

1.39

164

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

812

2.49

2.15

5.4

1.47

1.40

mmol/l

0.64

739

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

816

2.43

2.01

6.7

5.5

4.40

4.41

mmol/l

0.04

748

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

3.50

2.00

1.0

—

(3028026) IgM [Mass/volume] in Serum or Plasma

2.38

1.94

1.5

2.47

1.09

g/l

0.45

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

102

2.06

1.92

1.4

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

3.68

1.86

1.3

1.2

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

3.68

1.86

1.5

2.8

33.67

32.88

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

106

1.98

1.73

4.7

3.8

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

771

2.10

1.72

5.8

5.2

2.03

2.02

mu/l

0.02

688

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.40

1.70

1.4

2.8

11.24

10.34

g/l

0.53

(3023520) Reticulocytes [#/volume] in Blood

107

1.96

1.69

2.6

2.3

68.17

68.08

e9/l

0.00

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.02

1.68

1.3

1.5

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.63

1.63

1.3

1.2

—

(3021589) Normoblasts [#/volume] in Blood

399

1.63

1.59

19.1

13.1

0.01

0.00

e9/l

0.45

325

(3002179) Metamyelocytes/Leukocytes in Blood

2.00

1.56

5.1

3.5

0.25

0.39

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

411

1.61

1.54

3.9

2.8

—

estimate

—

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.25

1.50

1.4

2.7

2.97

3.07

g/l

0.13

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

177

1.72

1.49

1.9

—

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

887

2.66

1.49

40.2

29.3

39.89

39.98

0.06

878

(3000963) Hemoglobin [Mass/volume] in Blood

887

2.66

1.49

40.3

29.1

131.96

134.17

g/l

0.61

878

(3024731) MCV [Entitic mean volume] in Red Blood Cells

887

2.66

1.49

39.8

28.8

92.39

91.62

1.15

879

(3010813) Leukocytes [#/volume] in Blood

887

2.66

1.49

40.0

28.9

7.02

6.84

e9/l

0.21

865

(3026361) Erythrocytes [#/volume] in Blood

887

2.66

1.49

39.9

28.9

4.38

4.44

e12/l

0.50

865

(3035941) MCH [Entitic mass]

887

2.66

1.49

39.8

28.8

30.61

30.44

0.52

879

(3007461) Platelets [#/volume] in Blood

887

2.66

1.49

40.0

28.9

239.02

240.49

e9/l

0.06

871

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

838

2.10

1.47

6.7

6.4

2.45

2.54

mmol/l

0.43

768

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

784

1.95

1.44

5.4

4.5

1.14

1.27

mmol/l

1.37

706

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

214

1.65

1.42

6.2

2.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.98

1.38

1.6

—

(3049717) Cytology report of Urine Cyto stain

2.25

1.38

3.3

2.8

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

488

1.57

1.36

8.3

7.7

1.22

1.20

mmol/l

0.93

421

(3021960) Folate [Moles/volume] in Serum or Plasma

306

1.57

1.36

2.6

1.8

19.74

20.51

nmol/l

0.12

255

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

353

1.56

1.35

2.9

3.5

1867.36

1906.60

ng/l

0.02

297

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

865

2.25

1.33

18.2

13.0

24.60

23.95

u/l

0.19

839

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.12

1.33

1.4

2.6

4.00

4.10

g/l

0.19

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.12

1.33

1.4

2.6

7.15

7.25

g/l

0.06

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.12

1.33

1.4

2.6

3.56

3.68

g/l

0.09

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

262

1.58

1.32

3.3

3.2

0.71

0.77

ug/l

0.24

181

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

355

1.54

1.31

3.9

5.1

24.46

21.94

0.41

191

(3021788) Differential panel - Synovial fluid

2.87

1.30

2.2

1.1

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

142

1.70

1.28

1.4

3.26

12.14

u/ml

—

(3008898) HLA-B27 [Presence]

2.49

1.26

1.0

1.2

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.99

1.24

1.3

1.6

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

820

1.90

1.18

5.9

5.7

5.98

6.10

mmol/l

0.33

746

(3019309) Folate [Moles/volume] in Red Blood Cells

197

1.58

1.17

1.7

1125.67

1174.67

nmol/l

0.08

152

(46235355) HIV 1 and 2 tests - Meaningful Use set

122

1.69

1.13

1.5

1.7

—

(3044640) Blood type and Crossmatch panel - Blood

299

1.50

1.11

4.6

2.5

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.45

1.10

1.2

1.5

—

(3034770) Mitochondria Ab [Titer] in Serum

2.45

1.10

1.2

1.1

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.45

1.10

1.2

1.5

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.05

1.07

1.9

2.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

175

1.57

1.06

7.2

4.8

—

(3018418) pH of Serum or Plasma

292

1.48

1.06

5.7

4.5

7.40

7.39

0.55

218

(40761536) Microorganisms panel - Urine sediment

1.84

1.01

13.1

3.9

—

(3021440) Promyelocytes/Leukocytes in Blood

1.75

1.00

5.3

4.0

0.17

0.04

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

152

1.57

0.99

3.2

3.3

0.71

1.52

e6/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

450

1.43

0.97

2.3

2.7

—

(40758558) Short blood count panel - Blood

279

1.45

0.95

9.2

6.9

—

(3020682) Albumin/Creatinine [Ratio] in Urine

336

1.43

0.94

5.2

4.1

18.54

12.46

mg/mmol

0.18

215

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

226

1.47

0.91

1.4

1.9

423.17

428.81

pmol/l

0.04

189

(36660697) Celiac disease serology panel - Serum

1.78

0.86

1.2

1.3

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

1.99

0.86

9.3

2.8

2.51

1.82

mg/l

—

(3026008) Bacteria identified in Urine by Culture

275

1.42

0.85

5.5

3.4

—

(4035726) Immunohistochemistry procedure

1.67

0.83

1.2

1.4

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

159

1.49

0.81

3.0

3.1

0.20

0.92

e6/l

—

(3002582) Erythrocytes [#/volume] in Urine

324

1.39

0.81

6.6

3.6

102.02

241.68

e6/l

0.29

254

(3017181) Myelocytes/Leukocytes in Blood

1.63

0.80

5.3

3.9

0.50

0.77

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

134

1.51

0.78

1.9

1.8

—

(3025159) Blasts/Leukocytes in Blood

1.61

0.77

5.4

4.1

4.17

0.29

—

(3019150) Specific gravity of Urine by Refractometry

214

0.65

0.77

3.1

4.2

1.02

kg/l

—

149

(3009445) Proteinase 3 Ab [Units/volume] in Serum

1.90

0.75

1.0

1.2

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

1.90

0.75

1.4

1.7

35.86

38.86

u/l

—

(36304419) Bacteria [Presence] in Urine

262

1.39

0.75

6.8

3.3

—

estimate

—

(3037467) Urinalysis macro (dipstick) panel - Urine

596

1.37

0.73

6.6

4.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

128

1.49

0.72

2.0

1.9

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.97

0.71

1.0

1.5

—

(3012544) pH of Venous blood

111

1.52

0.71

4.1

4.4

7.37

7.38

—

(3030467) Casts [#/volume] in Urine by Automated count

283

1.36

0.71

7.1

3.4

0.10

0.36

e6/l

2.12

211

(3009508) Creatinine [Moles/volume] in Urine

332

1.34

0.68

4.0

3.3

5.58

7.72

mmol/l

3.75

273

(3000494) Fungus identified in Specimen by Culture

113

1.49

0.66

1.7

1.4

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

1.76

0.64

1.4

1.7

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

158

1.42

0.64

5.1

6.2

104.48

103.73

mmol/l

0.26

158

(3003694) ABO and Rh group [Type] in Blood

214

1.36

0.61

1.5

1.3

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.62

0.61

1.9

1.8

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.61

0.0

1.8

—

212.62

—

(44790049) Parainfluenza type 3 nucleic acid detection

0.00

0.60

0.0

1.3

—

(44790048) Parainfluenza type 2 nucleic acid detection

0.00

0.60

0.0

1.3

—

(44806118) Parainfluenza type 4 nucleic acid detection

0.00

0.60

0.0

1.3

—

(44790047) Parainfluenza type 1 nucleic acid detection

0.00

0.60

0.0

1.3

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

627

1.32

0.59

4.7

4.1

15.49

14.95

pmol/l

0.85

555

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.60

0.58

4.2

2.4

176.50

255.76

ng/l

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.71

0.58

1.2

—

(3012516) Albumin [Mass/volume] in Urine

330

1.30

0.56

4.0

3.3

94.28

79.52

mg/l

0.08

220

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.66

0.56

3.0

2.0

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.66

0.56

3.0

1.9

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

1.61

0.55

1.0

1.2

—

(3023368) Bacteria identified in Blood by Culture

304

1.29

0.53

5.5

4.7

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

663

1.30

0.52

36.8

24.9

13.88

13.89

0.01

657

(3018095) Leukocytes [#/volume] in Urine

355

1.26

0.49

7.3

4.3

38.34

85.27

e6/l

0.73

261

(3037756) Immunofixation for Serum or Plasma

1.59

0.43

1.2

1.4

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.41

0.0

1.1

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.4

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.40

0.40

1.8

1.4

—

(1761868) Lipid panel - Serum or Plasma

275

1.24

0.40

2.9

3.8

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

113

0.68

0.40

8.3

9.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

210

0.77

0.38

3.0

3.9

—

0.00

—

(40761511) CBC panel - Blood by Automated count

844

1.33

0.37

22.3

17.9

—

(3015736) pH of Urine

375

0.82

0.36

3.5

3.8

6.18

6.20

0.03

218

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

464

1.20

0.36

6.9

5.9

2.09

2.17

ug/l

0.11

407

(3018677) aPTT in Platelet poor plasma by Coagulation assay

166

1.26

0.33

6.8

2.1

31.45

29.13

0.50

161

(3007853) Bacteria identified in Skin by Aerobe culture

102

1.32

0.32

3.1

1.9

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

368

0.85

0.28

6.3

4.3

0.00

estimate

-0.00

(3009261) Glucose [Presence] in Urine by Test strip

488

0.86

0.27

5.6

4.2

0.00

3.20

estimate

0.50

(3035350) Ketones [Presence] in Urine by Test strip

487

0.86

0.26

5.6

4.1

0.00

15.18

estimate

0.50

107

(40761535) Cells panel - Urine sediment

1.22

0.26

2.8

3.7

—

(3042936) Bacteria identified in Isolate by Culture

162

1.21

0.25

2.9

1.9

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

1.30

0.23

1.7

4.5

89.70

94.78

ng/l

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.20

0.22

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

2.20

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.2

—

(3008401) Mugwort IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

1.64

—

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

0.63

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.5

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

4.4

—

3.30

—

(3016879) Cocaine [Presence] in Urine

0.00

0.21

0.0

1.3

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3027008) Opiates [Presence] in Urine

0.00

0.21

0.0

1.3

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.21

0.0

1.3

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.21

0.0

1.3

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.21

0.0

1.3

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.21

0.0

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.21

0.0

1.3

—

(3003129) Base excess in Capillary blood by calculation

0.00

0.21

0.0

1.5

—

0.37

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.27

0.20

1.0

1.3

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.27

0.20

3.0

2.7

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.26

0.19

1.3

1.6

1.53

1.76

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.14

0.17

1.0

1.5

—

(3019060) Gas panel - Arterial blood

0.77

0.16

3.0

4.2

—

(3019977) pH of Arterial blood

131

1.17

0.15

6.9

7.0

7.45

7.42

—

(3000991) Gas panel - Venous blood

1.21

0.15

5.4

8.2

—

(3021601) Nitrite [Presence] in Urine by Test strip

474

0.91

0.14

5.6

4.2

0.00

estimate

-0.00

101

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.04

0.09

1.2

1.9

—

(3025941) Bacteria identified in Stool by Culture

1.12

0.09

1.2

1.4

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

1.12

0.09

1.7

3.2

11.50

1853.33

u/ml

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.84

0.07

1.5

1.6

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

416

1.06

0.06

3.4

4.4

22.17

49.83

ng/l

2.45

338

(3029937) Albumin [Presence] in Urine by Test strip

288

0.96

0.02

7.2

4.1

0.00

estimate

-0.00

(3026493) Urate [Moles/volume] in Serum or Plasma

263

0.98

0.00

2.2

3.2

345.10

365.13

umol/l

0.41

223

(3041096) Erythrocytes [Presence] in Urine by Automated

274

0.98

0.00

6.7

3.8

0.00

0.33

estimate

0.49

(3036603) Volume of Urine

0.00

0.0

1.3

—

1573.75

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.3

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(4268621) Lupus anticoagulant assay

0.00

0.0

2.1

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.98

0.00

3.2

2.7

0.72

0.65

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(3011288) Drugs identified in Urine by Screen method Nominal

0.00

0.0

2.1

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.6

—

196.96

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

5.4

—

222.88

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.5

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

0.0

1.5

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

1.5

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.6

—

(4281824) Cell count and differential, peritoneal fluid

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

4.8

—

0.25

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.95

-0.00

3.2

2.7

0.92

1.02

—

(3025130) Human papilloma virus identified in Specimen

0.00

-0.00

0.0

2.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.7

—

15.87

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

-0.00

0.0

1.0

—

38.74

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.0

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

1.4

—

97.20

—

(3017315) Amylase [Enzymatic activity/volume] in Urine

0.00

-0.00

0.0

1.0

—

120.83

—

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

0.00

-0.00

0.0

1.9

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.98

-0.00

1.2

2.0

—

(4195642) Thrombophilia screening test

0.00

-0.00

0.0

1.6

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

-0.00

0.0

1.0

—

(3000492) Spirometry study

0.97

-0.00

1.4

1.5

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.3

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

-0.00

0.0

1.2

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

-0.00

0.0

1.2

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

0.89

-0.00

1.3

1.4

—

(3013727) Leukocytes other/Leukocytes in Blood

0.00

-0.00

0.0

6.5

—

50.83

—

(44806420) Estimation of glomerular filtration rate

0.00

-0.00

0.0

1.8

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.6

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.6

—

108.14

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

-0.00

0.0

2.2

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.4

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.2

—

(3011544) Albumin [Mass/volume] in Pleural fluid

0.00

-0.00

0.0

1.0

—

17.32

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

6.2

—

87.00

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_ACANTHOLYTIC and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
L12_ACANTHOLYTIC	1.27 [0.84, 1.93]	0.261
Birth year	0.987 [0.98, 1.0]	0.007

During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 245 males with L12_ACANTHOLYTIC died.

Mortality risk

Mortality risk for people of age

years, who have L12_ACANTHOLYTIC.

N-year risk	Females	Males
1	No data	0.234%
5	No data	1.37%
10	No data	3.526%
15	No data	6.809%
20	No data	11.671%

Relationships between endpoints

↥

Index endpoint: L12_ACANTHOLYTIC – Other acantholytic disorders

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other acantholytic disorders

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints