Transient acantholytic dermatosis [Grover]

L12_GROVER

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L11.1 Cause of death: ICD-10 — L11.1 2 out of 7 registries used, show all original rules.	75
4. Check minimum number of events None	75
5. Include endpoints None	75
6. Filter based on genotype QC (FinnGen only)	72

Control definitions (FinnGen only)

Control exclude: L12_BULLOUS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L11
Name in latin: Dermatosis acantholytica transitoria

NAME	L12_GROVER
CONTROL_EXCLUDE	L12_BULLOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L111
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L111
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Transient acantholytic dermatosis [Grover] based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	277	60	216
Only index persons	264	57	207
Unadjusted period prevalence (%)
Whole population	0.01	0.00	0.01
Only index persons	0.01	0.00	0.01
Median age at first event (years)
Whole population	74.29	72.41	74.76
Only index persons	74.06	72.09	74.61

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	72	20	52
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	74.57	74.07	74.76

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
73: Matched controls
730

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L11.1

ICD-10 Finland

Transient acantholytic dermatosis [Grover]

+∞

104.9

L30.9

ICD-10 Finland

Dermatitis, unspecified

14.2

30.5

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

15.0

29.2

E0000UV, ,

ATC

12.7

21.0

195

D07BB04

ATC

hydrocortisone butyrate and antiseptics; topical

9.6

18.9

D07AC01

ATC

betamethasone; topical

8.3

17.5

167

D05BB02

ATC

acitretin; oral

33.7

15.7

D07AC13

ATC

mometasone; topical

5.4

11.8

122

D07AB02

ATC

hydrocortisone butyrate; topical

5.2

11.2

132

D07AD01

ATC

clobetasol; topical

5.6

9.8

D07AB08

ATC

desonide; topical

5.9

8.9

L82

ICD-10 Finland

Seborrhoeic keratosis

4.1

7.8

111

R23.8

ICD-10 Finland

Other and unspecified skin changes

4.2

7.7

100

WXQ27

NOMESCO Finland

UVB narrow spectrum light therapy

+∞

7.4

XQ845

NOMESCO Finland

Dermatoscopy

22.8

7.4

XQ848

NOMESCO Finland

Dermatological photography

19.0

7.0

D10BA01

ATC

isotretinoin; oral

11.7

6.8

R06AE09

ATC

levocetirizine; oral

4.9

6.6

S02

ICPC

Pruritus

12.7

6.5

L29.8

ICD-10 Finland

Other pruritus

76.2

6.5

E000001, ,

ATC

3.8

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40768443) Skin Pathology biopsy report

27.41

22.92

1.7

1.1

—

(3007164) IgA [Mass/volume] in Serum or Plasma

107

3.22

5.02

1.6

1.4

2.33

2.63

g/l

0.33

(3019198) Lymphocytes [#/volume] in Blood

327

3.27

4.99

8.5

5.5

2.38

1.71

e9/l

0.55

284

(3013115) Eosinophils [#/volume] in Blood

332

3.18

4.77

8.5

5.7

0.21

0.20

e9/l

0.26

284

(3001604) Monocytes [#/volume] in Blood

323

3.12

4.74

8.5

5.4

0.64

e9/l

0.01

272

(40768797) Stomach Pathology biopsy report

104

3.14

4.71

1.4

1.3

—

(3006315) Basophils [#/volume] in Blood

324

3.10

4.69

8.6

5.4

0.04

e9/l

0.87

270

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

121

2.95

4.44

1.6

1.2

0.57

1.16

u/ml

—

(42870588) Differential panel, method unspecified - Blood

226

2.70

4.19

7.6

5.4

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

3.39

4.13

1.8

2.1

0.25

0.21

g/l

1.57

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

229

2.65

4.04

2.7

2.0

1.06

1.24

mmol/l

1.23

188

(3022145) Colonoscopy Study observation

3.03

3.75

1.7

1.3

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

5.87

3.64

1.2

1.5

—

(3020630) Protein [Mass/volume] in Serum or Plasma

3.04

3.63

1.3

2.0

66.56

65.17

g/l

0.43

(3004588) Protein electrophoresis panel - Serum or Plasma

3.13

3.50

1.2

1.9

—

(40768804) Tissue Pathology biopsy report

250

2.46

3.48

3.4

2.4

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

268

2.47

3.47

2.9

2.6

93.25

75.27

nmol/l

2.46

233

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

314

2.39

3.13

3.0

2.3

110.90

93.33

pmol/l

0.72

171

(3004616) Nuclear Ab [Presence] in Serum

8.04

3.11

1.2

1.0

—

(40760888) Immunoglobulin light chains.free panel - Serum

6.32

3.10

1.1

4.6

—

(3032080) INR in Blood by Coagulation assay

371

2.40

2.87

18.7

18.8

1.52

1.35

inr

0.88

317

(3013650) Neutrophils [#/volume] in Blood by Automated count

363

2.34

2.80

9.4

9.1

3.46

4.53

e9/l

4.35

312

(3002256) Pathology report gross observation

2.53

2.75

1.5

1.2

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

217

2.18

2.66

3.3

0.67

0.80

ug/l

0.69

149

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

5.83

2.60

1.3

1.4

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

370

2.26

2.58

4.7

7.0

13.49

13.69

umol/l

0.03

358

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

4.72

2.54

1.3

1.2

—

(3038026) Centromere Ab [Units/volume] in Serum

6.60

2.41

1.0

—

(3005719) IgG [Mass/volume] in Serum or Plasma

2.80

2.32

1.5

2.2

9.79

10.45

g/l

0.24

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

290

2.06

2.32

3.9

5.1

21.75

22.37

0.13

151

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

4.92

2.32

1.0

1.5

1.30

1.19

g/l

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

4.92

2.32

1.0

1.4

0.25

g/l

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

359

2.11

2.29

5.4

8.3

1.22

1.19

mmol/l

2.09

309

(3049717) Cytology report of Urine Cyto stain

3.27

2.23

3.3

3.2

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

114

2.18

2.16

2.0

7.1

0.99

1.05

mmol/l

0.42

108

(36660697) Celiac disease serology panel - Serum

2.70

2.04

1.2

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.96

2.01

1.2

2.5

11.28

10.16

g/l

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

4.79

1.97

1.0

1.1

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

585

2.77

1.92

5.5

1.52

1.38

mmol/l

1.53

524

(3008898) HLA-B27 [Presence]

4.39

1.85

1.0

1.3

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

3.25

1.85

1.3

1.1

—

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.71

1.81

1.2

2.4

2.91

3.02

g/l

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

588

2.69

1.77

7.1

5.6

4.27

4.34

mmol/l

0.22

534

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

2.19

1.74

2.3

2.4

5.60

10.87

umol/l

1.30

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

4.04

1.74

1.6

3.2

35.00

32.62

—

(3023520) Reticulocytes [#/volume] in Blood

2.13

1.71

2.8

2.5

65.55

70.74

e9/l

0.30

(3021960) Folate [Moles/volume] in Serum or Plasma

227

1.83

1.70

2.4

1.9

20.80

19.50

nmol/l

0.18

185

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.56

1.52

1.2

2.3

3.78

3.49

g/l

—

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.56

1.52

1.2

2.3

7.36

7.17

g/l

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.56

1.52

1.1

1.3

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.56

1.52

1.2

2.3

4.12

4.18

g/l

—

(3018418) pH of Serum or Plasma

209

1.74

1.43

3.2

4.5

7.40

7.39

0.71

157

(3028026) IgM [Mass/volume] in Serum or Plasma

2.36

1.43

1.2

1.6

3.06

1.03

g/l

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

563

2.11

1.42

5.6

4.8

1.07

1.27

mmol/l

2.50

499

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

142

1.79

1.35

1.5

1.8

0.76

1.27

mg/l

1.41

119

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

601

2.39

1.33

7.0

6.5

2.33

2.51

mmol/l

1.06

545

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.14

1.30

1.7

1.6

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

299

1.65

1.27

2.3

2.8

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

593

2.18

1.26

6.5

5.9

6.05

6.20

mmol/l

0.35

534

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

273

1.63

1.21

2.4

3.6

1323.70

1754.31

ng/l

0.52

229

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.42

1.21

1.2

—

(40761511) CBC panel - Blood by Automated count

607

2.26

1.19

19.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

304

1.61

1.16

2.6

2.7

—

estimate

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.47

1.16

2.0

2.6

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

446

1.69

1.15

4.4

4.0

15.53

15.01

pmol/l

0.76

391

(40760892) CBC W Ordered Manual Differential panel - Blood

132

1.71

1.12

4.6

4.4

—

(3002179) Metamyelocytes/Leukocytes in Blood

1.92

1.08

4.6

3.4

0.17

0.43

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.80

1.03

5.7

3.6

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

380

1.57

1.02

7.0

6.1

1.90

2.06

ug/l

0.25

332

(3037467) Urinalysis macro (dipstick) panel - Urine

432

1.60

1.01

5.7

5.1

—

(40761536) Microorganisms panel - Urine sediment

1.91

0.93

4.7

4.1

—

(3019309) Folate [Moles/volume] in Red Blood Cells

148

1.59

0.91

1.8

1117.31

1192.97

nmol/l

0.10

112

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.96

0.91

1.9

1.3

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.96

0.91

2.0

1.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

131

1.61

0.90

1.7

1.9

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

179

1.51

0.81

1.3

1.9

420.78

429.42

pmol/l

0.05

146

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.81

0.0

1.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.80

0.0

1.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.76

0.80

1.4

—

(40758558) Short blood count panel - Blood

189

1.49

0.79

8.3

6.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.88

0.75

1.0

1.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

251

1.41

0.68

3.7

4.2

23.39

12.68

mg/mmol

0.25

165

(3000494) Fungus identified in Specimen by Culture

1.62

0.67

1.2

1.4

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

1.84

0.67

1.0

1.1

—

(3025159) Blasts/Leukocytes in Blood

1.62

0.63

4.5

3.6

5.00

0.35

—

(4035726) Immunohistochemistry procedure

1.65

0.62

1.2

1.4

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.60

0.62

3.3

2.3

103.25

208.54

ng/l

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.61

0.0

1.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.00

0.60

0.0

1.5

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.59

0.0

1.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.57

0.57

1.3

1.4

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

238

1.36

0.57

2.3

167.76

226.87

u/l

0.48

224

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

468

1.39

0.56

31.3

25.5

13.69

13.97

0.76

463

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

110

1.46

0.54

3.5

3.2

0.22

0.87

e6/l

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

110

1.46

0.54

3.7

3.4

0.79

1.83

e6/l

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

1.46

0.54

1.4

2.1

13.63

12.29

nmol/l

—

(1761868) Lipid panel - Serum or Plasma

202

1.36

0.53

2.9

4.0

—

(3003694) ABO and Rh group [Type] in Blood

156

1.39

0.52

1.4

1.3

—

(3026008) Bacteria identified in Urine by Culture

203

1.35

0.52

4.6

3.5

—

(3003338) MCHC [Entitic Mass/volume] in Red Blood Cells

459

0.76

0.50

31.7

25.7

329.17

331.68

g/l

0.98

459

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.51

0.48

1.0

1.6

1.74

1.96

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

159

1.36

0.47

5.8

2.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.43

0.45

1.9

1.8

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

1.51

0.45

1.6

5.0

88.38

89.22

ng/l

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

1.60

0.43

1.2

2.5

0.80

0.47

g/l

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.60

0.43

1.0

1.2

—

(36304419) Bacteria [Presence] in Urine

190

1.31

0.42

4.6

3.1

—

estimate

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.3

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.40

0.0

1.2

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.40

0.0

1.8

—

218.44

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.40

0.0

1.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

211

1.28

0.39

3.2

3.9

0.00

0.39

estimate

0.49

(3019150) Specific gravity of Urine by Refractometry

155

0.73

0.38

2.3

4.1

1.02

kg/l

—

105

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.38

0.36

2.0

1.9

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

320

1.25

0.36

3.3

4.6

22.60

53.22

ng/l

2.04

266

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

1.36

0.34

1.7

3.0

11.50

2240.13

u/ml

—

(3009508) Creatinine [Moles/volume] in Urine

244

1.24

0.33

3.2

3.4

5.50

7.88

mmol/l

3.17

199

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.38

0.32

1.6

—

(3012516) Albumin [Mass/volume] in Urine

246

1.22

0.30

2.9

3.4

138.52

78.55

mg/l

0.24

171

(3044640) Blood type and Crossmatch panel - Blood

227

1.23

0.29

2.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.71

0.25

5.5

9.9

—

(3023368) Bacteria identified in Blood by Culture

231

1.19

0.24

4.7

4.9

—

(3012544) pH of Venous blood

1.29

0.22

4.5

4.7

7.37

7.38

—

(3003129) Base excess in Capillary blood by calculation

0.00

0.21

0.0

1.5

—

0.69

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.0

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.21

0.0

1.0

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.21

0.0

1.5

—

(44806118) Parainfluenza type 4 nucleic acid detection

0.00

0.21

0.0

1.2

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(44790047) Parainfluenza type 1 nucleic acid detection

0.00

0.21

0.0

1.2

—

(44790048) Parainfluenza type 2 nucleic acid detection

0.00

0.21

0.0

1.2

—

(44790049) Parainfluenza type 3 nucleic acid detection

0.00

0.21

0.0

1.2

—

(3018095) Leukocytes [#/volume] in Urine

264

1.16

0.20

5.3

4.2

41.73

89.19

e6/l

0.55

205

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.19

0.16

1.3

1.6

—

(3021601) Nitrite [Presence] in Urine by Test strip

348

1.13

0.15

3.2

4.3

0.00

estimate

-0.00

(3014576) Chloride [Moles/volume] in Serum or Plasma

114

1.17

0.13

3.2

6.6

102.92

103.54

mmol/l

0.17

114

(40761535) Cells panel - Urine sediment

1.08

0.09

1.2

2.9

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.04

0.07

2.9

1.9

—

(3035350) Ketones [Presence] in Urine by Test strip

357

1.07

0.06

3.2

4.2

0.00

19.80

estimate

0.49

(3009261) Glucose [Presence] in Urine by Test strip

359

1.06

0.04

3.2

4.3

0.00

4.11

estimate

0.50

(3018677) aPTT in Platelet poor plasma by Coagulation assay

131

1.09

0.04

1.5

1.9

32.79

29.01

0.61

126

(3029937) Albumin [Presence] in Urine by Test strip

221

1.06

0.03

3.3

4.1

0.00

estimate

-0.00

(3015736) pH of Urine

273

1.04

0.01

2.2

3.9

6.09

6.15

0.07

161

(3042936) Bacteria identified in Isolate by Culture

113

0.97

0.00

3.1

1.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

282

0.99

0.00

3.1

4.2

0.00

estimate

-0.00

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.2

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3032700) Glomerular basement membrane Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3011544) Albumin [Mass/volume] in Pleural fluid

0.00

-0.00

0.0

1.0

—

17.32

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

0.92

-0.00

3.2

7.7

1.80

1.53

mmol/l

—

(3000991) Gas panel - Venous blood

0.90

-0.00

3.7

9.0

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

4.5

—

3.55

—

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

0.00

-0.00

0.0

1.8

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

3.2

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.4

—

91.20

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.3

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

1.5

—

(3017315) Amylase [Enzymatic activity/volume] in Urine

0.00

-0.00

0.0

1.0

—

125.40

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

3.5

—

22.33

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.4

—

(3009595) Pneumocystis jirovecii DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

5.2

—

259.95

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3027944) Amphetamines [Presence] in Urine

0.00

-0.00

0.0

1.2

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3027008) Opiates [Presence] in Urine

0.00

-0.00

0.0

1.2

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

(3028300) Cannabinoids [Presence] in Urine

0.00

-0.00

0.0

1.2

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

-0.00

0.0

1.2

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.7

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3011648) Oxygen content in Venous blood

0.00

-0.00

0.0

1.6

—

10.11

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

2.0

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.2

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

-0.00

0.0

2.9

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.3

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.1

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.3

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.0

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

16.18

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

3.6

—

0.29

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

-0.00

0.0

1.2

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

2.8

—

215.60

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.2

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

0.92

-0.00

1.4

—

(3036603) Volume of Urine

0.00

-0.00

0.0

1.4

—

1498.00

—

(3016879) Cocaine [Presence] in Urine

0.00

-0.00

0.0

1.2

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3013727) Leukocytes other/Leukocytes in Blood

0.00

-0.00

0.0

5.0

—

58.20

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_GROVER and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_GROVER.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_GROVER – Transient acantholytic dermatosis [Grover]

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Transient acantholytic dermatosis [Grover]

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints