No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
313 |
4. Check minimum number of eventsNone |
313 |
5. Include endpointsNone |
313 |
6. Filter based on genotype QC (FinnGen only) |
282 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Similar endpoints
↥List of similar endpoints to
Primary amenorrhea
based on the number of shared cases.
Similar with more cases:
- Amenorrhoea
- Irregular menses
- Polycystic ovarian syndrome, consortium definition
- Noninflammatory disorders of female genital tract
- Genitourinary diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 282 | 282 | - |
| Unadjusted period prevalence (%) | 0.10 | 0.10 | - |
| Median age at first event (years) | 16.93 | 16.93 | - |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 292
- Matched controls
- 2920
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N91.0
ICD-10 Finland
Primary amenorrhoea
+∞
307.7
292
*
G03DB01
ATC
dydrogesterone; oral
10.6
88.1
132
210
N91.1
ICD-10 Finland
Secondary amenorrhoea
10.9
59.4
73
87
F50.0
ICD-10 Finland
Anorexia nervosa
15.0
48.9
46
36
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
4.8
34.0
102
292
G03FB08
ATC
dydrogesterone and estrogen; systemic
11.0
31.9
36
37
G03FB06
ATC
medroxyprogesterone and estrogen; systemic
12.3
31.7
33
30
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
8.7
26.1
35
45
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
8.0
25.6
37
52
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
6.4
22.8
41
73
N97.0
ICD-10 Finland
Female infertility associated with anovulation
6.2
19.2
35
63
Q51.0
ICD-10 Finland
Agenesis and aplasia of uterus
191.1
17.7
18
*
121
Kela drug reimbursment
Severe hypofunction of sexual glands
14.1
15.5
26
20
F50.9
ICD-10 Finland
Eating disorder, unspecified
5.6
14.7
29
56
E30.09
ICD-10 Finland
Delayed puberty NOS
146.5
13.6
14
*
Q52.0
ICD-10 Finland
Congenital absence of vagina
146.5
13.6
14
*
E28.3
ICD-10 Finland
Primary ovarian failure
22.5
13.5
19
9
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.9
12.1
69
283
LC2DE
NOMESCO Finland
Demanding ultrsound examination of uterus, parametrium and lower part of abdomen with speciel methods
3.7
10.2
34
100
Z3226
NOMESCO Finland
Physiotherapist
2.7
9.9
62
265
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
+∞
9.4
9
*
N91.2
ICD-10 Finland
Amenorrhoea, unspecified
7.6
8.9
20
28
F50.1
ICD-10 Finland
Atypical anorexia nervosa
8.0
8.8
19
25
G03FB05
ATC
norethisterone and estrogen; systemic
4.1
8.1
23
60
E30.00
ICD-10 Finland
Familial delayed puberty
34.4
8.1
10
*
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
2.2
8.0
85
460
X05
ICPC
Menstruation absent/scanty
3.4
7.9
30
96
XLA10, ,
NOMESCO Finland
7.6
7.3
16
22
Z2221
NOMESCO Finland
Medical doctor
2.0
6.8
92
541
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.3
6.8
57
278
G03FB09
ATC
levonorgestrel and estrogen; systemic
14.7
6.4
10
7
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
101
192
7.51
55.13
2.5
1.5
7.73
8.44
u/l
0.28
82
147
70
133
6.61
37.21
2.3
1.6
0.20
0.40
nmol/l
2.74
64
115
98
273
4.90
33.75
2.4
1.4
7.41
15.66
iu/l
5.10
78
223
91
305
3.88
23.59
1.7
1.5
274.02
306.29
mu/l
0.46
86
270
45
87
5.93
23.03
1.4
1.4
1.22
1.85
nmol/l
1.22
39
80
30
82
3.96
9.99
1.7
1.5
15.20
11.85
u/l
0.29
30
74
31
102
3.28
7.85
1.5
1.6
314.74
390.50
mu/l
0.65
31
82
113
770
1.76
5.03
5.0
4.1
38.32
38.16
g/l
0.11
106
725
152
1129
1.72
4.95
3.1
2.5
71.12
69.25
nmol/l
0.52
146
1060
48
248
2.12
4.90
3.4
2.8
225.58
542.68
ng/l
1.49
37
192
121
871
1.66
4.25
7.7
6.2
1.22
1.22
mmol/l
0.18
103
758
109
767
1.67
4.16
6.0
5.7
1.22
1.22
mmol/l
0.08
98
718
253
2227
2.02
4.12
5.8
4.7
14.21
14.23
pmol/l
0.05
235
2057
7
8
8.93
3.79
1.4
1.0
1.93
2.37
nmol/l
—
7
8
8
13
6.29
3.52
1.1
1.1
12.75
21.62
pmol/l
—
8
13
9
18
5.12
3.39
1.2
1.3
—
—
—
0
0
218
1880
1.63
3.26
4.6
3.7
37.34
35.57
mmol/mol
1.71
205
1792
55
346
1.73
3.09
5.2
4.5
8.75
12.80
mg/mmol
0.35
37
240
7
13
5.49
2.88
2.0
1.2
113.71
57.69
nmol/24h
—
7
13
244
2192
1.69
2.80
9.5
8.0
102.80
103.38
ml/min/173m2
0.15
208
1862
14
54
2.67
2.74
1.3
1.4
—
—
—
0
0
76
536
1.56
2.72
2.0
2.4
11.04
13.41
ng/l
0.61
35
179
31
171
1.91
2.67
3.3
6.4
105.00
105.48
mmol/l
0.29
31
171
268
2483
1.97
2.64
7.1
5.6
1.78
1.71
mu/l
0.63
258
2382
10
30
3.41
2.63
4.8
1.3
8.98
4.97
pmol/l
—
10
30
171
1452
1.43
2.32
10.8
7.5
3.55
3.92
e9/l
1.32
149
1267
157
1313
1.42
2.31
3.9
4.1
6.13
5.96
mmol/l
0.42
146
1129
6
15
4.06
2.05
10.5
11.4
730.67
963.20
nmol/l
—
6
15
270
2542
1.82
2.00
9.8
8.2
22.58
22.14
u/l
0.15
265
2479
9
33
2.78
1.95
1.1
1.2
—
—
—
0
0
6
16
3.80
1.94
16.7
19.3
1224.83
1839.81
nmol/l
—
6
16
9
34
2.70
1.88
1.1
1.1
—
—
—
0
0
9
34
2.70
1.88
1.1
1.2
—
—
—
0
0
9
34
2.70
1.88
1.2
1.5
—
—
—
0
0
9
34
2.70
1.88
1.1
1.1
—
—
—
0
0
9
35
2.62
1.81
1.1
1.1
—
—
—
0
0
73
557
1.41
1.73
1.7
1.4
20.93
19.60
nmol/l
0.46
66
497
22
130
1.75
1.58
5.1
4.5
5.43
5.09
kpa
0.64
22
124
20
115
1.79
1.57
1.6
1.6
—
—
—
0
0
9
38
2.41
1.47
1.1
1.2
—
—
—
0
0
106
882
1.32
1.43
1.9
1.7
100.97
95.31
pmol/l
0.71
49
501
60
767
0.73
1.41
1.8
1.6
1217.99
968.22
mu/l
1.27
54
672
50
370
1.42
1.41
1.3
1.3
43.54
142.58
u/ml
4.12
14
139
71
559
1.36
1.39
2.4
2.1
0.70
0.90
mg/l
0.40
46
391
34
235
1.51
1.35
1.5
1.6
1236.23
1029.65
nmol/l
0.57
27
180
13
70
1.90
1.26
1.7
1.2
—
—
—
0
0
30
425
0.67
1.25
1.7
1.5
59.96
63.02
ug/l
0.16
25
370
12
63
1.94
1.24
1.4
1.3
44.82
39.64
nmol/l
0.10
12
57
27
181
1.54
1.23
2.6
5.2
3.10
1.07
mmol/l
2.46
22
148
203
1862
1.30
1.23
3.9
3.3
50.86
47.16
ug/l
0.40
196
1784
48
363
1.39
1.20
2.3
2.6
1.79
0.79
e6/l
0.60
26
168
213
1971
1.30
1.18
3.5
2.8
1.09
1.08
mmol/l
0.10
202
1883
0
35
0.00
1.16
0.0
1.4
—
285.71
—
0
7
22
326
0.65
1.15
2.1
1.8
—
—
—
0
0
93
785
1.27
1.09
3.3
2.7
24.39
25.15
u/l
0.26
87
747
34
247
1.43
1.08
2.7
2.2
20.35
24.61
%
1.33
29
226
175
1591
1.25
1.07
7.3
5.9
74.89
71.35
u/l
0.56
166
1491
8
148
0.53
1.07
2.3
1.5
—
—
—
0
0
229
2150
1.30
1.06
4.2
3.3
2.65
2.71
mmol/l
0.57
218
2070
22
148
1.53
1.01
1.6
1.9
—
—
—
0
0
115
1004
1.24
1.00
5.8
4.8
10.29
9.27
umol/l
0.76
105
929
163
1478
1.23
0.99
3.6
3.4
0.00
0.00
estimate
-0.00
39
348
0
29
0.00
0.98
0.0
2.4
—
1.23
—
0
15
26
358
0.70
0.95
2.2
1.7
—
—
—
0
0
115
1009
1.23
0.95
1.8
1.5
1.55
2.46
u/ml
0.45
39
275
36
271
1.37
0.95
3.3
2.3
23.73
207.35
ng/l
0.80
11
96
7
37
1.91
0.94
1.3
1.1
—
—
—
0
0
38
489
0.74
0.92
1.5
1.5
—
—
—
0
0
11
180
0.60
0.89
1.5
1.3
—
—
—
0
0
83
710
1.24
0.86
3.3
3.2
—
—
—
0
0
265
2560
1.38
0.83
11.2
10.3
20.75
18.53
mg/l
0.60
205
2042
8
46
1.76
0.83
3.7
1.9
98.94
134.49
ug/l
—
8
41
192
1789
1.21
0.82
4.2
3.6
9.46
8.18
mm/h
1.04
183
1676
226
2142
1.24
0.81
3.8
3.2
1.57
1.51
mmol/l
1.11
215
2060
162
1489
1.20
0.79
3.7
3.4
28.12
4.38
estimate
0.39
41
344
163
1500
1.20
0.78
3.7
3.4
0.03
0.00
estimate
0.49
38
340
43
344
1.29
0.78
2.3
2.8
7.97
5.92
e6/l
0.33
21
148
32
410
0.75
0.77
1.4
1.6
3.00
3.12
ratio
0.22
22
285
20
141
1.45
0.77
2.7
5.8
24.91
23.76
mmol/l
0.93
20
141
0
28
0.00
0.76
0.0
1.2
—
72.40
—
0
5
23
167
1.41
0.76
2.7
3.0
—
—
—
0
0
24
176
1.40
0.75
1.7
1.6
—
—
—
0
0
9
54
1.69
0.75
1.0
1.1
—
—
—
0
0
25
185
1.38
0.75
1.7
1.6
—
—
—
0
0
30
385
0.75
0.73
1.4
1.5
1.05
1.17
ratio
0.55
16
248
30
385
0.75
0.73
1.4
1.5
1.09
0.94
ratio
1.40
16
248
30
385
0.75
0.73
1.4
1.5
1.10
1.20
ratio
0.32
17
248
5
25
2.02
0.73
1.0
1.3
—
—
—
0
0
25
329
0.74
0.72
1.2
1.5
2.90
3.14
mmol/l
1.31
16
213
9
57
1.60
0.72
5.8
12.1
0.49
0.60
%
—
9
57
226
2153
1.22
0.71
3.9
3.2
4.57
4.59
mmol/l
0.13
215
2078
7
42
1.68
0.69
1.1
1.1
—
—
—
0
0
5
28
1.80
0.66
1.0
3.7
27.86
10.75
u/ml
—
5
28
224
2138
1.20
0.65
4.3
3.1
5.52
5.39
mmol/l
0.58
205
1994
70
606
1.20
0.65
2.7
2.9
0.54
0.22
e6/l
0.49
47
417
30
376
0.77
0.63
1.4
1.5
—
—
—
0
0
42
505
0.80
0.62
1.3
1.3
1.52
7.39
u/ml
2.42
19
193
5
30
1.68
0.61
2.0
1.5
3.12
2.81
g/l
—
5
30
47
393
1.23
0.61
2.9
2.8
300.03
288.56
umol/l
0.29
40
362
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
6
35
1.73
0.58
1.2
1.1
—
—
—
0
0
6
35
1.73
0.58
1.5
2.0
—
—
—
0
0
6
35
1.73
0.58
1.5
1.2
—
—
—
0
0
6
35
1.73
0.58
1.5
1.2
—
—
—
0
0
19
142
1.36
0.56
1.4
1.4
—
—
—
0
0
36
296
1.25
0.55
2.6
2.1
2.57
2.55
g/l
0.09
31
263
9
61
1.49
0.54
5.9
11.5
1.23
0.96
%
—
9
61
74
655
1.17
0.54
2.8
2.3
54.51
54.77
u/l
0.03
68
603
9
62
1.47
0.53
1.0
1.1
—
—
—
0
0
6
39
1.55
0.53
1.2
1.1
—
—
—
0
0
235
2424
0.84
0.51
4.2
4.4
—
—
—
0
0
19
146
1.32
0.48
2.9
8.5
25.09
24.78
mmol/l
0.14
19
146
7
47
1.50
0.48
1.1
1.2
—
—
—
0
0
5
83
0.60
0.46
1.0
1.7
—
—
—
0
0
16
121
1.34
0.45
2.0
2.4
0.35
0.17
e6/l
0.43
16
114
5
31
1.62
0.43
2.0
1.5
3.58
3.59
g/l
—
5
31
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
5
31
1.62
0.43
2.0
1.5
6.28
6.95
g/l
—
5
31
5
31
1.62
0.43
2.0
1.5
4.18
4.53
g/l
—
5
31
10
70
1.44
0.42
1.3
1.2
—
—
—
0
0
38
325
1.19
0.42
2.6
2.1
12.78
15.39
umol/l
1.86
32
297
5
33
1.52
0.41
1.0
1.1
—
—
—
0
0
5
33
1.52
0.41
1.4
1.3
131.40
61.70
ug/l
—
5
33
0
16
0.00
0.41
0.0
1.1
—
153.99
—
0
16
0
18
0.00
0.40
0.0
1.7
—
94.67
—
0
18
5
35
1.44
0.39
1.0
1.1
—
—
—
0
0
5
35
1.44
0.39
1.0
1.1
—
—
—
0
0
88
808
1.13
0.39
4.0
3.3
0.00
0.00
estimate
0.50
37
335
12
89
1.36
0.38
1.4
1.4
45.42
89.00
pmol/l
0.49
12
84
9
69
1.31
0.37
1.3
1.2
—
—
—
0
0
6
42
1.44
0.35
1.0
1.3
—
—
—
0
0
6
88
0.68
0.33
1.0
1.1
—
—
—
0
0
90
837
1.11
0.32
2.0
1.7
1.26
1.22
mmol/l
0.21
82
760
31
268
1.18
0.32
1.8
1.8
—
—
—
0
0
7
53
1.33
0.31
1.4
1.7
0.60
0.51
e9/l
—
7
53
15
120
1.26
0.30
1.3
1.1
0.77
0.80
g/l
0.24
15
120
12
94
1.29
0.28
1.1
1.5
—
—
—
0
0
14
171
0.81
0.27
1.4
1.5
—
—
—
0
0
8
67
1.20
0.26
1.9
1.3
—
—
—
0
0
5
74
0.67
0.26
3.0
2.1
—
—
—
0
0
9
72
1.26
0.26
1.2
1.1
—
—
—
0
0
20
232
0.85
0.23
1.2
1.3
—
—
—
0
0
14
168
0.82
0.23
1.5
1.5
0.23
0.15
mg/l
—
7
63
17
144
1.19
0.22
1.9
2.2
—
—
—
0
0
111
1160
0.93
0.21
2.3
2.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
46.00
—
0
11
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
26
292
0.88
0.21
1.8
1.5
59.11
55.77
ug/l
0.19
26
292
16
136
1.19
0.20
1.6
1.6
—
—
—
0
0
6
48
1.26
0.20
1.8
1.8
12.58
13.30
%
—
6
48
119
1237
0.94
0.19
2.5
2.5
—
—
—
0
0
116
1116
1.07
0.18
3.5
3.0
0.00
0.02
estimate
0.88
34
294
49
525
0.92
0.18
1.3
1.3
10.64
23.67
iu/ml
2.30
12
135
60
635
0.93
0.16
2.0
2.0
—
—
—
0
0
49
460
1.08
0.15
2.4
2.4
11.98
12.78
e6/l
0.06
42
406
10
84
1.20
0.14
1.1
1.7
—
—
—
0
0
39
364
1.08
0.14
1.6
1.5
224242929.97
41590644.81
pmol/l
0.37
33
327
23
212
1.09
0.10
2.8
2.9
38.06
32.86
%
1.84
17
161
13
116
1.13
0.09
1.2
1.5
278.57
199.45
u/ml
—
7
70
6
54
1.11
0.09
1.0
1.2
—
136.67
—
0
15
6
57
1.05
0.08
1.3
1.3
—
2401.57
—
0
9
89
869
1.03
0.07
1.4
1.6
—
—
—
0
0
7
84
0.83
0.07
2.0
1.5
—
—
—
0
0
135
1328
1.03
0.07
2.5
2.8
—
—
estimate
—
0
0
78
760
1.04
0.07
2.5
2.2
2.37
2.49
mg/l
0.22
65
661
12
132
0.91
0.07
1.3
1.3
—
—
—
0
0
67
688
0.97
0.06
3.5
2.9
1.02
1.02
kg/l
0.57
46
428
26
274
0.94
0.06
1.4
1.3
212.57
262.38
miu/ml
0.26
14
135
27
284
0.95
0.06
1.2
1.0
—
—
—
0
0
13
119
1.10
0.06
1.0
1.0
1.52
1.59
g/l
0.57
13
119
173
1745
0.98
0.04
3.3
3.0
28.07
25.71
u/l
0.33
164
1684
80
787
1.02
0.03
3.0
2.0
—
—
—
0
0
28
273
1.03
0.01
1.3
1.4
—
—
—
0
0
24
238
1.01
0.00
2.4
3.9
5.58
5.10
umol/l
0.17
19
184
11
111
0.99
0.00
1.3
1.2
—
5.25
—
0
14
53
532
1.00
0.00
2.7
2.4
3773.26
6774.77
u/l
0.41
19
218
121
1206
1.01
0.00
2.5
2.0
—
—
—
0
0
17
175
0.97
0.00
2.2
2.4
—
—
—
0
0
13
126
1.03
0.00
1.8
1.4
—
—
—
0
0
92
917
1.00
0.00
3.0
2.3
—
—
—
0
0
90
903
1.00
0.00
2.7
2.6
0.00
0.02
estimate
0.88
31
295
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
6.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
1.63
—
0
6
5
57
0.88
-0.00
1.2
1.3
—
—
—
0
0
5
49
1.02
-0.00
2.2
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
20.17
—
0
6
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
9
92
0.98
-0.00
1.3
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
5
55
0.91
-0.00
1.2
1.1
—
1.84
—
0
10
0
6
0.00
-0.00
0.0
1.3
—
5.24
—
0
6
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
1888.67
—
0
6
0
7
0.00
-0.00
0.0
1.1
—
19.32
—
0
7
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
7
79
0.88
-0.00
2.6
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
1.20
—
0
6
0
6
0.00
-0.00
0.0
12.0
—
0.33
—
0
6
9
95
0.95
-0.00
1.1
1.2
—
8.21
—
0
14
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: N14_PRIMARY_AMENORRHEA – Primary amenorrhea
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).