Allergic contact dermatitis due to drugs in contact with skin

ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L23.3#

1 out of 7 registries used, show all original rules.

924

4. Check minimum number of events

None

924

5. Include endpoints

None

924

6. Filter based on genotype QC (FinnGen only)

838

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5347 3692 1635
Only index persons 5018 3503 1515
Unadjusted period prevalence (%)
Whole population 0.09 0.11 0.05
Only index persons 0.11 0.13 0.06
Median age at first event (years)
Whole population 53.77 53.75 53.80
Only index persons 53.05 52.95 53.27

-FinnGen-

Key figures

All Female Male
Number of individuals 838 595 243
Unadjusted period prevalence (%) 0.18 0.21 0.11
Median age at first event (years) 55.87 53.88 60.74

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
857
Matched controls
8570
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
17.7
307.7
434
470
L23.3
ICD-10 Finland
Allergic contact dermatitis due to drugs in contact with skin
4503599627370496.0
307.7
854
5
XQ802
NOMESCO Finland
Epicutan test
42.4
307.7
407
179
L23.2
ICD-10 Finland
Allergic contact dermatitis due to cosmetics
59.4
281.7
160
33
XQ800
NOMESCO Finland
Prick test
13.6
275.4
315
351
L23.0
ICD-10 Finland
Allergic contact dermatitis due to metals
44.1
251.5
153
42
L23.5
ICD-10 Finland
Allergic contact dermatitis due to other chemical products
37.1
142.9
90
27
L30.9
ICD-10 Finland
Dermatitis, unspecified
5.5
133.4
409
1222
L23.8
ICD-10 Finland
Allergic contact dermatitis due to other agents
37.6
105.6
66
19
E0000UV, ,
ATC
4.8
105.4
590
2694
L23.1
ICD-10 Finland
Allergic contact dermatitis due to adhesives
57.5
104.2
59
11
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
8.9
101.4
137
179
L20.0
ICD-10 Finland
Besnier prurigo
6.4
96.3
186
358
D07AC13
ATC
mometasone; topical
4.0
87.5
432
1740
L23.9
ICD-10 Finland
Allergic contact dermatitis, unspecified cause
20.1
85.6
67
36
D07AC01
ATC
betamethasone; topical
3.8
81.8
497
2273
L30.3
ICD-10 Finland
Infective dermatitis
8.3
72.7
102
138
E000001, ,
ATC
3.8
70.2
303
1086
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
4.2
68.1
226
673
D07AB08
ATC
desonide; topical
4.4
66.3
202
564
R06AE07
ATC
cetirizine; oral
3.2
58.3
532
2918
D07AD01
ATC
clobetasol; topical
3.4
53.8
250
920
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
11.2
53.8
58
55
D11AH01
ATC
tacrolimus; topical
19.2
52.8
42
23
T78.4
ICD-10 Finland
Allergy, unspecified
5.7
47.7
95
184
D07AB02
ATC
hydrocortisone butyrate; topical
2.8
47.3
374
1840
XQ899
NOMESCO Finland
Other assessment of skin
18.4
45.7
37
21
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
12.1
45.0
46
40
H02AB06
ATC
prednisolone; systemic
2.7
44.4
525
3135
D07BC01
ATC
betamethasone and antiseptics; topical
3.6
44.1
174
571
E000006, ,
ATC
4.2
42.0
124
332
D07CC01
ATC
betamethasone and antibiotics; topical
3.3
40.9
188
677
D09AB01
ATC
zinc bandage without supplements; topical
9.2
39.6
49
56
D02AE01
ATC
carbamide; topical
4.3
39.4
112
291
XQ801
NOMESCO Finland
Intracutantest
14.4
39.3
36
26
R06AX27
ATC
desloratadine; oral
2.6
38.5
349
1797
TQW80
NOMESCO Finland
Local dermatologic skincare
7.1
36.1
56
84
D02AX
ATC
Other emollients and protectives
5.9
35.5
66
119
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.5
35.5
138
445
E000002, ,
ATC
3.3
34.8
154
538
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
5.5
34.8
70
136
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.5
31.8
267
1306
L23
ICD-10 Finland
Allergic contact dermatitis
12.8
31.6
31
25
C01CA24
ATC
epinephrine; parenteral
3.6
30.1
109
334
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
9.8
29.9
35
37
L50.0
ICD-10 Finland
Allergic urticaria
5.9
29.0
53
94
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.2
27.6
125
440
R06AE09
ATC
levocetirizine; oral
2.6
27.1
182
793
D07XC01
ATC
betamethasone; topical
2.9
26.5
146
574
L30.0
ICD-10 Finland
Nummular dermatitis
4.6
26.4
65
150
L30.8
ICD-10 Finland
Other specified dermatitis
5.2
26.4
56
114
H02AB07
ATC
prednisone; oral
2.7
25.1
162
690
N05BB01
ATC
hydroxyzine; systemic
3.5
25.0
91
279
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.1
23.7
105
364
R06AX22
ATC
ebastine; oral
2.4
23.7
200
965
E000003, ,
ATC
4.0
23.6
71
191
J01FF01
ATC
clindamycin; systemic
2.2
22.9
284
1603
D07AA02
ATC
hydrocortisone; topical
2.5
22.1
168
770
S29
ICPC
Skin symptom/complaint other
2.2
20.6
221
1171
E000004, ,
ATC
5.6
19.9
38
70
L20
ICD-10 Finland
Atopic dermatitis
4.6
19.6
48
110
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.4
19.2
145
660
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
3.1
17.3
75
256
H02AB04
ATC
methylprednisolone; systemic
2.2
16.9
155
766
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.8
16.8
53
147
A46
ICD-10 Finland
Erysipelas
2.3
16.6
142
681
E000007, ,
ATC
3.1
16.5
71
241
S01GX01
ATC
cromoglicic acid; ophthalmic
2.0
16.3
214
1213
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
4.7
16.2
38
84
H10.1
ICD-10 Finland
Acute atopic conjunctivitis
4.2
15.8
42
103
XQ820
NOMESCO Finland
Exposure to medicinal substance
17.6
15.7
24
14
XQ848
NOMESCO Finland
Dermatological photography
4.1
15.6
44
113
ZXX01
NOMESCO Finland
Extent of proceudre, 1 unit
14.3
15.1
25
18
J01DB01
ATC
cefalexin; oral
2.2
15.0
729
6197
ZXX04
NOMESCO Finland
Extent of procedure, 4 units
25.5
14.7
20
8
S87
ICPC
Dermatitis/atopic eczema
4.1
14.5
40
101
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
14.4
180
998
D05BB02
ATC
acitretin; oral
4.8
14.3
32
68
J02AC01
ATC
fluconazole; systemic
1.8
14.2
383
2700
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
14.1
343
2347
L50.8
ICD-10 Finland
Other urticaria
4.7
14.1
33
73
L04AX03
ATC
methotrexate; systemic
2.4
14.1
107
486
L50.9
ICD-10 Finland
Urticaria, unspecified
3.3
14.0
55
177
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
13.4
419
3064
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.0
13.4
59
203
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
13.3
215
1295
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.7
12.5
376
2703
L21.8
ICD-10 Finland
Other seborrhoeic dermatitis
5.7
12.5
23
41
J02AC02
ATC
itraconazole; systemic
1.9
12.4
174
1000
R03AC02
ATC
salbutamol; inhalant
1.7
12.2
503
3921
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
5.0
12.2
26
53
S88
ICPC
Dermatitis contact/allergic
4.1
12.2
33
82
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
12.0
266
1755
R06AX13
ATC
loratadine; oral
2.0
12.0
151
835
R03DC03
ATC
montelukast; oral
1.9
12.0
167
956
D07CB01
ATC
triamcinolone and antibiotics; topical
4.8
12.0
27
58
J01CF05
ATC
flucloxacillin; systemic
2.5
11.7
79
339
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
3.9
11.7
34
89
ZXX05
NOMESCO Finland
Extent of procedure, 5 units
30.5
11.7
15
5
L29.9
ICD-10 Finland
Pruritus, unspecified
3.4
11.5
41
124
S76
ICPC
Skin infection other
2.7
11.5
61
233
D06AX01
ATC
fusidic acid; topical
2.2
11.4
97
461
SPAT1263
SPAT
Sampling
1.7
11.4
361
2613
R01AD08
ATC
fluticasone; nasal
1.7
11.4
257
1700
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.0
11.3
136
739
L30.4
ICD-10 Finland
Erythema intertrigo
5.0
11.3
24
49
XG410
NOMESCO Finland
Flow-volume spirometry
3.2
11.0
43
138
C05AA08
ATC
fluocortolone; rectal, topical
2.0
10.8
130
707
D07AC14
ATC
methylprednisolone aceponate; topical
2.8
10.7
53
195
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.1
10.5
112
583
A02BC05
ATC
esomeprazole; systemic
1.6
10.5
355
2601
T88.7
ICD-10 Finland
Unspecified adverse effect of drug or medicament
4.3
10.4
27
65
Z09.8
ICD-10 Finland
Follow-up examination after other treatment for other conditions
3.1
10.4
43
143
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.6
10.2
62
253
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.2
10.2
92
448
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
3.8
10.1
30
80
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
4.9
10.1
22
46
R03BA05
ATC
fluticasone; inhalant
1.8
10.0
169
1023
L26
ICD-10 Finland
Exfoliative dermatitis
26.4
9.8
13
5
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.4
9.8
71
315
J01DA01
ATC
[U] cefalexin
1.6
9.7
530
4319
A92
ICPC
Allergy/allergic reaction NOS
3.1
9.7
40
133
L30.1
ICD-10 Finland
Dyshidrosis [pompholyx]
11.5
9.6
17
15
J30.4
ICD-10 Finland
Allergic rhinitis, unspecified
2.8
9.4
46
168
D11AX14
ATC
[U] tacrolimus
12.5
9.4
16
13
D07XB05
ATC
dexamethasone; topical
3.4
9.2
33
100
R01AD09
ATC
mometasone; nasal
1.6
9.0
398
3068
D07AB01
ATC
clobetasone; topical
3.0
9.0
39
133
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
9.0
378
2884
X59
ICD-10 Finland
Exposure to unspecified factor
1.8
8.9
165
1024
L23.7
ICD-10 Finland
Allergic contact dermatitis due to plants, except food
24.3
8.9
12
5
J01AA04
ATC
lymecycline; systemic
1.9
8.8
121
685
D06
ICPC
Abdominal pain localized other
2.1
8.8
83
412
J01MA12
ATC
levofloxacin; systemic
1.8
8.8
156
958
L17
ICPC
Foot/toe symptom/complaint
1.6
8.8
274
1950
D05AX52
ATC
calcipotriol, combinations; topical
2.6
8.7
50
199
L50.3
ICD-10 Finland
Dermatographic urticaria
3.7
8.6
27
75
L25.9
ICD-10 Finland
Unspecified contact dermatitis, unspecified cause
8.3
8.6
18
22
ZXX03
NOMESCO Finland
Extent of procedure, 3 units
11.7
8.6
15
13
L23.4
ICD-10 Finland
Allergic contact dermatitis due to dyes
27.8
8.5
11
*
R51.80
ICD-10 Finland
Headache
1.8
8.4
150
921
D11AH02
ATC
pimecrolimus; topical
12.9
8.4
14
11
A02BC02
ATC
pantoprazole; systemic
1.6
8.3
579
4901
XCK00
NOMESCO Finland
Perimetry
2.4
8.0
57
251
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.7
7.9
173
1123
Z04.3
ICD-10 Finland
Examination and observation following other accident
3.5
7.9
26
75
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
7.8
224
1556
N06AX21
ATC
duloxetine; oral
1.8
7.7
115
668
R06.0
ICD-10 Finland
Dyspnoea
1.6
7.6
236
1667
N03AX16
ATC
[U] pregabalin
1.6
7.6
200
1359
NF1AA
NOMESCO Finland
Hip X-ray examination
2.0
7.5
81
422
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
2.9
7.5
35
125
NH1AD
NOMESCO Finland
Ankle and foot CT
3.6
7.5
24
68
R06.2
ICD-10 Finland
Wheezing
2.5
7.4
45
184
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
1.5
7.4
281
2074
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.4
7.4
48
203
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.8
7.4
107
617
L03.9
ICD-10 Finland
Cellulitis, unspecified
3.7
7.3
23
64
L40.3
ICD-10 Finland
Pustulosis palmaris et plantaris
4.2
7.3
19
46
SPAT1229
SPAT
Assessment of need for aid
2.2
7.3
63
302
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.0
7.2
74
379
6918B
ICD-9 Finland
Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[ECZEMA ATOPICUM]
7.4
7.2
16
22
M25.5
ICD-10 Finland
Pain in joint
1.5
7.2
298
2238
D11AH04
ATC
alitretinoin; oral
20.2
7.1
10
5
D07AC03
ATC
desoximetasone; topical
3.8
7.1
21
56
J45.9
ICD-10 Finland
Asthma, unspecified
1.6
7.0
167
1105
EKA10
NOMESCO Finland
iopsy of buccal mucosa
3.4
7.0
25
76
WZC30
NOMESCO Finland
Teaching
1.7
7.0
139
877
S06
ICPC
Rash localized
2.3
7.0
51
228
L28
ICPC
Limited function/disability (L)
1.6
7.0
160
1049
C03CA01
ATC
furosemide; systemic
1.5
6.9
228
1627
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.6
6.9
40
160
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.7
6.9
122
745
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.6
6.8
165
1095
J01DA09
ATC
[U] cefadroxil
1.6
6.8
217
1537
WXQ12
NOMESCO Finland
Psoralen - Ultraviolet A therapy with local sensitivisation
9.4
6.8
13
14
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
6.8
114
686
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.4
6.8
47
205
L29.8
ICD-10 Finland
Other pruritus
5.7
6.8
18
32
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.8
6.7
105
618
SPAT1255
SPAT
Intravenous administration of medicine
2.2
6.7
57
271
H04.10
ICD-10 Finland
Dry eye syndrome
1.8
6.7
114
688
L01
ICPC
Neck symptom/complaint
1.7
6.7
146
943
WQ007, ,
NOMESCO Finland
22.7
6.7
9
*
J01MA02
ATC
ciprofloxacin; systemic
1.5
6.7
307
2349
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
6.7
183
1253
H25.8
ICD-10 Finland
Other senile cataract
1.9
6.6
89
500
Z51.6
ICD-10 Finland
Desensitization to allergens
5.5
6.6
18
33
H60.8
ICD-10 Finland
Other otitis externa
2.7
6.6
35
134
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
3.5
6.6
22
64
WQ000
NOMESCO Finland
Hyposensibilisation
10.1
6.5
12
12
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.7
6.5
112
678
N02BE01
ATC
paracetamol; systemic, rectal
1.8
6.5
757
6958
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
2.5
6.5
39
159
SPAT1254
SPAT
Administration of medicine
1.7
6.5
119
735
H01.0
ICD-10 Finland
Blepharitis
2.0
6.5
69
359
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.1
6.4
58
283
A02BC01
ATC
omeprazole; systemic
1.5
6.4
218
1564
D07XB02
ATC
triamcinolone; topical
4.1
6.4
17
42
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
6.4
229
1663
A01
ICPC
Pain general/multiple sites
1.8
6.4
93
537
M75.3
ICD-10 Finland
Calcific tendinitis of shoulder
3.6
6.3
20
56
R42
ICD-10 Finland
Dizziness and giddiness
1.6
6.3
193
1352
NH1BA
NOMESCO Finland
Ankle extensive X-ray examination
3.0
6.3
27
92
R03BA02
ATC
budesonide; inhalant
1.6
6.2
156
1044
S21
ICPC
Skin texture symptom/complaint
1.7
6.2
130
832
T78.2
ICD-10 Finland
Anaphylactic shock, unspecified
4.0
6.2
17
43
M54.5
ICD-10 Finland
Low back pain
1.5
6.2
311
2413
L43.8
ICD-10 Finland
Other lichen planus
3.4
6.2
21
62
PD4DE
NOMESCO Finland
Lower extremity artery ultrasound examination with Doppler method
3.4
6.2
21
62
N30.0
ICD-10 Finland
Acute cystitis
1.6
6.1
155
1039
N03AX12
ATC
[U] gabapentin; oral
1.6
6.1
139
909
L24.8
ICD-10 Finland
Irritant contact dermatitis due to other agents
10.1
6.0
11
11
DHB50
NOMESCO Finland
Turbinoplasty
3.0
6.0
26
89
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
6.0
91
531

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
173
553
3.67
45.73
1.7
1.3
531.72
223.71
u/ml
1.59
167
514
109
348
3.44
28.24
1.4
1.2
—
—
—
0
0
162
703
2.61
24.08
4.8
4.3
7.38
7.36
ph
1.18
104
500
203
982
2.40
23.89
2.1
1.4
—
—
—
0
0
513
3643
2.02
21.60
8.3
6.2
0.69
0.68
%
0.21
490
3419
510
3647
1.98
20.66
8.2
6.1
3.21
2.81
%
2.95
487
3429
513
3681
1.98
20.51
8.0
6.0
56.23
57.28
%
1.23
494
3523
509
3652
1.97
20.25
8.4
6.2
8.80
8.69
%
0.45
488
3438
517
3744
1.96
19.84
8.3
6.1
28.29
27.85
%
0.41
496
3560
387
2575
1.92
18.84
7.7
6.0
—
—
—
0
0
540
4053
1.90
17.64
7.9
6.1
2.03
1.90
e9/l
0.54
495
3594
531
3977
1.88
17.31
7.9
6.0
0.04
0.04
e9/l
2.07
478
3432
530
3968
1.88
17.29
7.9
6.0
0.61
0.57
e9/l
2.70
477
3421
544
4107
1.89
17.28
8.0
6.4
0.24
0.19
e9/l
3.00
495
3618
57
168
3.56
16.57
1.1
1.1
2.67
2.26
u/ml
0.10
35
93
170
881
2.16
16.42
2.4
1.7
—
—
—
0
0
374
2616
1.76
14.30
4.8
3.5
—
0.63
—
0
8
201
1160
1.96
14.30
1.6
1.3
584.35
528.77
titre
0.14
46
260
49
145
3.52
14.17
1.1
1.0
8.40
3.14
u/ml
0.84
28
77
106
488
2.34
13.51
1.5
1.3
50.15
38.59
au/ml
—
6
36
40
108
3.84
13.22
1.4
1.3
—
—
—
0
0
112
534
2.26
13.14
2.9
2.5
15.32
22.81
au/ml
0.65
12
44
559
4438
1.75
13.13
10.4
9.5
4.06
4.07
e9/l
0.04
501
3882
88
384
2.44
12.62
2.0
2.2
0.00
0.01
estimate
0.50
15
120
686
5824
1.89
12.41
10.6
8.1
77.32
78.65
u/l
0.41
656
5528
20
14
14.59
12.31
1.1
1.1
0.08
0.02
u/ml
0.85
20
14
66
256
2.71
12.05
5.2
4.1
25.29
24.93
mmol/l
0.46
59
243
348
2472
1.69
12.00
3.1
2.5
54.11
60.76
u/l
1.40
319
2299
489
3830
1.64
11.26
8.7
7.0
1.22
1.21
mmol/l
0.84
426
3306
618
5149
1.72
11.14
4.6
3.2
46.60
44.66
u/l
0.27
574
4863
443
3394
1.63
11.08
2.5
2.1
98.19
96.83
pmol/l
0.20
234
1747
205
1282
1.79
11.02
2.7
2.4
13.03
13.12
umol/l
0.07
192
1196
198
1238
1.78
10.61
1.7
1.7
1037.10
1197.45
nmol/l
1.59
143
934
444
3431
1.61
10.51
7.2
6.3
1.22
1.21
mmol/l
1.42
401
3161
76
338
2.37
10.45
5.4
3.7
—
—
—
0
0
139
784
1.92
10.33
2.4
2.1
387.52
382.18
nmol/l
0.10
126
737
22
46
4.88
10.05
2.5
1.3
22.76
24.77
umol/l
0.10
22
41
20
22
9.28
10.05
1.1
1.0
11.25
12.27
u/ml
—
8
16
503
4032
1.60
10.01
7.5
6.4
9.95
11.09
umol/l
2.94
475
3856
132
741
1.92
9.93
2.3
2.2
0.00
0.02
estimate
0.50
22
147
180
1116
1.78
9.86
2.5
2.0
—
—
—
0
0
540
4426
1.59
9.58
5.6
4.8
6.57
6.57
mmol/l
0.02
517
4196
60
250
2.51
9.50
1.3
1.3
32.32
8.43
u/ml
—
5
49
96
491
2.08
9.38
5.2
3.5
7.42
7.42
ph
0.09
79
411
187
1198
1.72
9.06
2.6
2.4
2.37
2.32
g/l
0.51
173
1116
286
2049
1.59
8.91
2.6
2.2
2.71
2.83
mg/l
0.40
252
1764
96
505
2.01
8.68
5.2
3.5
5.16
5.09
kpa
0.39
90
490
12
6
20.25
8.48
1.1
1.2
0.74
0.03
u/ml
—
12
6
73
350
2.19
8.42
1.8
2.0
5.53
8.20
iu/ml
0.41
13
87
375
2901
1.52
8.10
4.9
3.8
181.80
67.87
ng/l
0.32
261
2011
447
3590
1.51
8.06
3.0
2.5
77.66
77.80
nmol/l
0.03
400
3242
592
5051
1.56
8.02
6.0
4.8
399.43
2285.47
e6/l
—
7
79
38
137
2.86
8.00
1.1
1.1
0.54
0.81
u/ml
0.39
22
59
52
220
2.45
8.00
1.1
1.1
2.10
7.69
eliau/ml
—
5
28
170
1102
1.68
7.79
2.8
2.4
21.99
22.97
%
0.50
161
1034
24
66
3.71
7.78
1.7
1.2
2.87
1.77
u/ml
0.16
18
34
264
1909
1.55
7.70
1.4
1.3
2.32
1.72
u/ml
0.26
56
520
278
2036
1.54
7.64
5.2
4.2
—
—
—
0
0
466
3801
1.50
7.63
3.5
3.1
113.14
111.09
ug/l
0.08
436
3554
112
657
1.81
7.28
1.3
1.2
—
—
—
0
0
804
7493
2.18
7.25
24.1
17.8
139.61
139.69
mmol/l
0.37
787
7351
60
284
2.20
7.16
1.6
1.6
8.09
9.19
u/ml
—
10
57
33
118
2.87
7.07
1.3
1.2
—
—
—
0
0
804
7508
2.15
6.96
24.4
18.0
3.96
3.96
mmol/l
0.22
786
7350
313
2388
1.49
6.95
2.4
2.1
173.40
198.88
u/l
0.35
296
2264
423
3430
1.46
6.85
14.7
13.7
1.17
1.22
inr
1.43
369
2842
188
1288
1.59
6.83
3.4
3.2
0.82
0.82
mmol/l
0.16
170
1212
679
6065
1.58
6.69
5.8
4.5
14.88
14.72
pmol/l
0.86
623
5577
290
2217
1.47
6.23
3.3
3.2
1452.73
1140.50
ng/l
0.66
237
1894
295
2268
1.46
6.13
2.0
1.7
19.48
20.91
nmol/l
0.76
246
1912
11
11
10.11
6.04
1.1
1.0
7.80
0.05
u/ml
—
6
6
768
7117
1.76
6.04
5.8
5.1
5.80
5.87
mmol/l
1.08
700
6559
758
7014
1.70
5.80
7.3
5.6
1.86
1.87
mu/l
0.08
699
6525
67
362
1.92
5.64
2.3
2.0
—
—
—
0
0
42
191
2.26
5.56
5.1
4.3
—
—
—
0
0
55
280
2.03
5.49
1.1
1.2
—
—
—
0
0
385
3158
1.40
5.41
2.2
2.1
—
—
—
0
0
751
6958
1.64
5.40
7.1
6.2
39.19
38.89
mmol/mol
0.41
697
6525
226
1686
1.46
5.38
1.4
1.5
2.45
2.32
g/l
0.45
134
1041
820
7799
2.19
5.38
27.6
20.0
77.19
74.29
umol/l
1.63
813
7711
817
7761
2.13
5.35
16.4
11.9
25.35
24.93
u/l
0.37
802
7557
14
26
5.46
5.24
1.0
1.0
0.48
0.76
u/ml
—
6
14
313
2490
1.40
5.21
3.1
2.4
—
—
—
0
0
33
139
2.43
5.20
1.1
1.1
4.24
1.34
u/ml
0.79
20
72
237
1804
1.43
5.03
2.0
1.6
0.92
1.20
mg/l
1.57
175
1402
783
7360
1.74
4.99
23.0
15.4
19.95
22.97
mg/l
2.05
685
6035
142
978
1.54
4.95
2.9
3.3
5.68
4.77
e9/l
0.25
116
853
326
2636
1.38
4.85
3.7
3.2
30.59
30.94
u/l
0.06
304
2498
747
6957
1.57
4.72
4.9
4.2
1.30
1.26
mmol/l
0.81
682
6406
99
636
1.63
4.64
2.9
3.0
66.45
67.06
g/l
0.31
90
593
122
832
1.54
4.44
2.3
2.7
1.79
1.86
%
0.37
103
749
98
636
1.61
4.41
2.5
2.8
72.22
71.67
e9/l
0.05
75
464
472
4085
1.35
4.39
4.4
4.0
0.00
0.00
estimate
0.50
101
850
398
3358
1.35
4.39
6.9
4.8
35.55
35.91
g/l
0.64
375
3167
476
4127
1.35
4.36
4.5
4.0
0.00
4.04
estimate
0.80
103
867
28
120
2.38
4.29
1.1
1.0
10.85
2.68
u/ml
0.87
18
55
775
7314
1.62
4.23
5.8
5.1
4.67
4.69
mmol/l
0.27
723
6835
206
1572
1.41
4.23
1.4
1.3
39.91
30.81
iu/ml
0.26
62
496
305
2487
1.35
4.16
4.0
3.1
—
—
—
0
0
772
7288
1.60
4.10
5.7
5.0
1.47
1.50
mmol/l
1.49
709
6770
12
26
4.67
4.06
1.1
1.8
92.75
74.88
nmol/24h
0.32
12
26
237
1863
1.38
4.06
3.0
2.4
—
—
—
0
0
99
659
1.57
4.01
5.3
4.3
0.46
0.59
%
0.43
37
203
56
321
1.80
3.98
1.1
1.6
—
12.17
—
0
9
126
887
1.49
3.95
2.3
2.5
9.73
6.96
umol/l
0.35
106
776
24
100
2.44
3.92
10.7
5.2
10.77
11.97
mg/l
0.79
24
91
782
7418
1.62
3.91
6.3
5.7
2.75
2.74
mmol/l
0.14
724
6904
26
113
2.34
3.88
1.2
1.1
17.13
6.20
u/ml
1.06
11
46
476
4169
1.32
3.86
4.5
4.0
0.00
0.38
estimate
0.52
104
822
275
2235
1.34
3.76
3.7
3.1
0.00
0.04
—
9
48
83
539
1.60
3.74
2.7
2.5
—
—
—
0
0
48
269
1.83
3.69
3.1
3.4
244.21
346.46
mg/l
0.72
19
107
185
1418
1.39
3.66
1.8
1.9
—
—
—
0
0
14
45
3.15
3.66
1.3
1.0
3.17
0.36
u/ml
—
5
10
94
632
1.55
3.66
2.9
2.6
6.03
6.10
ph
0.35
54
418
98
670
1.52
3.54
5.5
4.8
0.03
0.17
%
1.17
34
171
188
1455
1.37
3.50
1.4
1.3
12.26
11.58
u/ml
0.04
63
563
236
1893
1.34
3.49
3.1
2.7
337.46
332.29
umol/l
0.37
206
1678
96
656
1.52
3.48
5.3
4.4
0.06
0.12
%
0.63
33
179
149
1112
1.41
3.44
1.3
1.2
—
—
—
0
0
14
47
3.01
3.42
1.1
1.0
5.33
0.27
u/ml
—
6
20
141
1043
1.42
3.42
3.1
2.4
176.24
115.60
ug/g
1.06
109
834
18
70
2.61
3.40
1.1
1.1
103.67
108.54
pmol/l
0.13
18
70
100
694
1.50
3.37
5.2
4.3
0.76
1.00
%
0.57
37
217
7
10
7.05
3.37
1.1
1.1
0.62
0.03
u/ml
—
7
10
826
7993
1.92
3.28
33.0
23.7
256.52
254.16
e9/l
0.45
814
7848
826
7994
1.92
3.26
32.9
23.6
91.18
91.08
fl
0.26
819
7917
826
7995
1.92
3.25
32.8
23.5
30.30
30.28
pg
0.12
819
7917
826
7995
1.92
3.25
33.4
24.0
39.56
40.05
%
1.77
819
7914
826
7995
1.92
3.25
33.1
23.7
6.90
6.68
e9/l
1.37
811
7826
826
7995
1.92
3.25
33.0
23.6
4.41
4.45
e12/l
1.64
810
7828
39
214
1.86
3.23
1.3
2.5
11.58
12.37
mg/l
0.25
34
200
826
7998
1.91
3.19
33.2
23.8
132.88
133.98
g/l
1.55
819
7918
19
79
2.44
3.15
3.3
3.7
—
—
—
0
0
792
7593
1.57
3.08
19.9
13.9
—
—
—
0
0
382
3322
1.27
2.99
3.6
3.5
6.18
6.22
ph
0.28
211
1913
188
1491
1.33
2.96
3.9
2.9
563.36
520.37
mosm/kgh2o
1.96
177
1308
123
913
1.41
2.93
1.3
1.3
—
—
—
0
0
42
244
1.76
2.92
3.1
3.9
53.34
69.56
mg/l
0.25
35
209
46
275
1.71
2.90
1.7
2.1
9.65
10.69
g/l
0.91
39
252
407
3582
1.26
2.83
3.3
2.8
—
—
estimate
—
0
0
39
224
1.78
2.82
2.6
3.6
1.50
2.38
ratio
1.16
26
128
57
365
1.60
2.78
2.4
2.3
—
—
—
0
0
7
14
5.03
2.73
1.7
4.3
—
—
—
0
0
21
98
2.17
2.72
1.2
1.0
0.85
0.41
u/ml
—
7
29
148
1148
1.35
2.70
1.9
2.0
28.98
29.37
s
0.42
143
1113
40
235
1.74
2.69
1.3
1.4
273.50
295.73
ug/g
0.27
26
145
20
92
2.20
2.69
1.2
1.3
—
—
nmol/l
—
0
0
27
140
1.96
2.68
1.1
1.1
10.79
19.23
au/ml
—
7
41
41
244
1.71
2.64
3.1
3.9
33.23
60.12
mg/l
0.91
34
209
104
764
1.41
2.64
5.8
3.2
7.39
7.39
ph
0.36
63
440
17
74
2.32
2.59
1.3
1.3
2.94
2.68
g/l
—
9
54
17
74
2.32
2.59
1.3
1.3
0.38
0.37
g/l
—
9
54
17
74
2.32
2.59
1.3
1.3
5.92
7.02
g/l
—
9
56
6
11
5.48
2.54
2.8
4.3
8.00
7.38
mmol/l
—
6
11
17
75
2.29
2.52
1.3
1.3
—
—
—
0
0
332
2890
1.24
2.45
4.5
3.9
130.11
96.01
e6/l
0.42
246
2018
10
32
3.15
2.44
1.1
1.1
—
—
—
0
0
77
544
1.46
2.42
1.3
1.2
—
—
—
0
0
154
1221
1.32
2.42
1.7
1.6
—
—
—
0
0
98
732
1.38
2.27
5.8
3.2
1.82
1.93
mmol/l
0.10
90
622
265
2274
1.24
2.19
4.4
3.4
0.35
0.04
estimate
0.41
72
685
81
593
1.40
2.12
1.4
1.4
—
—
—
0
0
15
68
2.23
2.12
3.3
2.7
—
—
—
0
0
114
886
1.33
2.07
1.6
1.5
—
—
—
0
0
20
103
1.96
2.06
1.8
2.0
6.42
5.84
umol/l
0.11
13
73
33
200
1.68
2.05
2.8
3.3
1.21
2.20
index
0.74
14
108
191
1591
1.26
2.04
1.6
1.7
464.57
38421492.37
pmol/l
1.97
164
1330
125
991
1.31
1.97
7.8
5.1
1.11
1.03
mmol/l
2.00
116
913
89
673
1.36
1.94
1.4
1.4
—
—
—
0
0
13
58
2.26
1.91
1.1
1.7
5.45
6.54
mmol/l
—
6
37
312
2755
1.21
1.90
3.0
3.4
2.35
2.36
mmol/l
0.63
273
2509
293
2575
1.21
1.87
3.4
3.3
7.18
7.47
mmol/l
0.53
241
2182
22
122
1.82
1.85
1.1
1.2
—
—
—
0
0
17
87
1.97
1.80
1.4
1.1
—
—
—
0
0
20
109
1.85
1.78
1.2
1.3
0.51
17.27
nmol/l
0.50
20
102
279
2451
1.21
1.78
4.2
4.1
9.57
8.10
mg/mmol
0.22
169
1497
22
124
1.79
1.77
1.4
1.8
0.67
0.80
g/l
0.29
14
99
6
18
3.35
1.75
1.5
1.5
—
—
—
0
0
8
30
2.68
1.72
4.9
1.8
38.37
40.62
g/l
—
8
30
5
13
3.86
1.71
2.2
2.0
—
—
—
0
0
5
13
3.86
1.71
1.0
1.0
—
—
—
0
0
37
243
1.55
1.70
1.3
1.3
—
—
—
0
0
5
14
3.59
1.61
1.2
1.2
—
—
—
0
0
81
623
1.33
1.61
4.4
3.6
126.31
78.57
ng/l
1.16
67
555
8
32
2.51
1.60
1.5
1.6
—
—
—
0
0
17
92
1.86
1.57
1.1
1.1
—
—
—
0
0
491
5240
0.85
1.52
3.9
4.0
—
0.11
—
0
9
13
65
2.02
1.49
1.2
1.2
—
—
—
0
0
280
2496
1.18
1.48
4.1
3.3
27.44
78.44
e6/l
1.20
226
1913
9
37
2.45
1.48
1.2
3.7
1064.22
788.24
u/ml
—
9
37
257
2277
1.18
1.46
4.3
4.1
0.00
0.00
estimate
0.75
93
810
16
278
0.57
1.46
1.4
1.2
0.93
0.90
g/l
0.19
16
278
27
411
0.65
1.44
1.1
1.1
—
—
—
0
0
270
2409
1.18
1.41
3.4
3.4
50.29
43.83
mg/l
0.21
165
1522
19
111
1.73
1.40
1.3
1.3
—
73.85
—
0
8
34
231
1.49
1.38
2.6
1.7
—
—
—
0
0
9
41
2.21
1.37
1.1
2.2
4.42
6.19
nmol/l
—
9
34
26
167
1.57
1.35
3.1
3.9
13.92
26.98
mg/l
1.57
15
114
143
1208
1.22
1.35
3.8
3.0
2.63
2.82
e6/l
0.13
80
587
16
270
0.58
1.33
1.4
1.2
1.49
1.58
g/l
0.98
16
270
154
1316
1.21
1.30
3.7
2.8
1.20
1.03
e6/l
0.16
91
697
5
18
2.79
1.28
1.0
1.1
—
—
—
0
0
5
18
2.79
1.28
4.2
1.4
—
—
—
0
0
22
138
1.61
1.27
1.3
1.3
17.01
27.48
u/l
0.82
17
118
6
25
2.41
1.24
2.5
1.6
24.17
30.44
%
—
6
25
26
171
1.54
1.24
1.8
1.3
—
—
—
0
0
9
45
2.01
1.23
1.4
1.2
—
—
—
0
0
15
85
1.78
1.23
1.6
1.6
—
—
—
0
0
34
477
0.70
1.23
14.1
9.9
94.71
93.98
%
0.61
34
472
11
56
1.98
1.22
2.4
1.9
47.33
39.79
%
0.83
11
56
8
37
2.17
1.21
3.0
2.4
—
—
—
0
0
17
101
1.70
1.20
6.1
2.5
—
—
—
0
0
15
86
1.76
1.19
1.8
2.3
—
—
—
0
0
104
864
1.23
1.17
1.8
1.7
—
—
—
0
0
341
3137
1.14
1.15
4.4
3.9
6.33
0.03
estimate
0.49
79
706
80
647
1.26
1.14
4.8
2.7
4.46
4.46
kpa
0.00
80
628
7
30
2.34
1.12
1.1
1.2
—
—
—
0
0
372
3448
1.14
1.11
13.2
11.1
0.00
0.00
e9/l
0.52
304
2837
13
73
1.79
1.11
1.2
1.2
—
—
—
0
0
9
166
0.54
1.08
1.8
3.6
13.89
27.64
u/ml
—
9
161
7
32
2.20
1.08
1.1
1.1
—
—
—
0
0
7
32
2.20
1.08
1.1
1.1
—
—
—
0
0
7
32
2.20
1.08
1.1
1.1
—
—
—
0
0
11
59
1.88
1.07
1.0
1.1
—
—
—
0
0
16
97
1.66
1.07
1.2
1.2
0.17
0.18
nmol/l
0.20
11
72
256
2322
1.15
1.05
4.1
4.1
7.40
7.40
ph
0.43
187
1661
71
576
1.25
1.01
1.9
2.4
5.21
6.27
ug/l
0.35
58
507
23
156
1.49
0.99
1.1
1.1
—
—
—
0
0
7
36
1.95
0.97
1.1
1.3
111.57
149.09
nmol/l
—
7
36
41
312
1.33
0.95
2.0
1.8
1.23
2.29
ug/l
0.47
36
278
41
314
1.32
0.92
1.1
1.1
—
—
—
0
0
161
1430
1.15
0.89
4.7
3.8
278.31
348.57
ng/l
0.15
123
1060
63
513
1.25
0.89
3.7
3.6
4.34
4.53
pmol/l
0.66
54
462
8
42
1.91
0.88
2.9
1.6
86.88
85.82
ng/l
—
8
42
42
325
1.31
0.88
1.7
2.0
1.72
1.49
g/l
0.73
37
291
8
43
1.87
0.87
1.0
1.0
—
—
—
0
0
235
2146
1.13
0.86
4.2
3.1
0.23
0.42
e6/l
2.66
183
1574
14
88
1.60
0.84
5.8
1.5
258.33
278.37
mosm/kgh2o
—
9
63
19
130
1.47
0.81
1.8
1.4
—
—
—
0
0
341
3193
1.11
0.81
2.1
1.9
1.36
1.34
mmol/l
0.23
291
2711
22
156
1.42
0.79
1.1
1.1
—
—
—
0
0
90
771
1.19
0.79
1.7
1.5
—
—
—
0
0
0
26
0.00
0.78
0.0
1.5
—
54.75
—
0
20
58
700
0.82
0.77
1.4
1.4
—
—
—
0
0
9
53
1.71
0.75
1.1
1.1
300.33
295.52
mg/l
—
9
48
89
766
1.18
0.75
1.6
1.7
—
—
—
0
0
72
610
1.20
0.72
4.0
3.8
1.22
1.23
mmol/l
0.32
66
532
19
134
1.43
0.71
2.0
1.5
—
—
—
0
0
57
473
1.22
0.71
1.6
1.4
27.04
27.29
iu/l
0.02
52
410
24
178
1.36
0.69
1.3
1.2
—
—
—
0
0
12
77
1.57
0.68
1.3
1.3
—
—
—
0
0
5
27
1.86
0.68
1.6
1.8
—
—
—
0
0
7
42
1.67
0.68
2.4
1.8
—
—
—
0
0
21
153
1.38
0.67
1.6
1.4
—
—
—
0
0
15
103
1.46
0.65
1.2
1.2
—
—
—
0
0
83
721
1.17
0.64
3.7
2.4
29.76
37.48
u/l
1.11
67
597
28
216
1.31
0.64
1.5
1.2
38.57
96.67
titre
—
7
24
28
216
1.31
0.64
1.1
1.2
—
—
—
0
0
12
177
0.67
0.64
1.8
1.8
44.08
41.20
nmol/l
0.16
12
166
10
153
0.65
0.63
2.1
2.4
58.60
100.98
ug/min
—
5
87
6
103
0.58
0.62
2.0
2.0
32.00
32.30
pg
—
6
103
5
30
1.67
0.61
4.0
3.2
—
—
—
0
0
8
50
1.61
0.61
1.4
1.3
73.88
73.44
umol/l
—
8
50
0
20
0.00
0.60
0.0
1.5
—
8.45
—
0
20
8
52
1.54
0.59
1.0
1.0
—
—
—
0
0
0
23
0.00
0.58
0.0
1.1
—
39.72
—
0
9
72
626
1.16
0.57
1.3
1.2
228.19
141.47
u/ml
0.61
27
263
94
834
1.14
0.57
8.3
7.8
1.08
1.02
mmol/l
0.05
80
690
95
844
1.14
0.56
1.4
1.5
—
—
—
0
0
20
150
1.34
0.56
4.8
2.6
13.84
7.66
pmol/l
0.74
20
150
22
168
1.32
0.55
1.5
1.5
—
—
—
0
0
10
66
1.52
0.52
1.9
1.3
—
—
—
0
0
10
66
1.52
0.52
1.4
1.1
—
—
—
0
0
57
490
1.17
0.52
3.7
2.8
40.06
73.41
u/ml
0.66
52
472
6
41
1.47
0.50
1.0
1.0
2567.67
1661.27
miu/ml
—
6
41
23
180
1.29
0.50
4.0
3.3
54.17
59.07
%
0.91
23
180
18
136
1.33
0.49
4.2
3.5
4.54
4.35
e9/l
0.16
18
136
172
1849
0.91
0.49
3.6
4.1
1.02
1.83
kg/l
0.50
114
1243
24
190
1.27
0.48
1.8
1.5
15700.35
15245.91
e6/l
0.02
17
137
94
847
1.12
0.47
8.2
7.7
5.14
5.09
kpa
0.18
89
819
94
848
1.12
0.46
8.6
7.7
7.42
7.42
ph
0.40
53
482
186
1740
1.09
0.45
3.2
2.6
6.28
6.71
e6/l
0.16
177
1584
194
1819
1.09
0.45
6.1
4.6
—
—
—
0
0
8
58
1.38
0.41
1.4
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
8
59
1.36
0.41
1.1
1.2
—
—
—
0
0
24
195
1.24
0.41
1.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
2.6
—
—
—
0
0
5
35
1.43
0.39
4.2
2.9
—
—
—
0
0
171
1608
1.08
0.37
5.3
5.7
2.29
2.45
ug/l
0.17
155
1445
8
113
0.71
0.37
2.0
1.6
—
—
—
0
0
10
72
1.39
0.37
1.7
1.1
—
—
—
0
0
32
273
1.18
0.35
2.2
2.5
—
—
—
0
0
6
44
1.37
0.34
2.3
2.9
0.33
0.75
index
—
6
44
6
87
0.69
0.33
1.7
1.3
—
—
—
0
0
6
46
1.31
0.33
1.3
1.6
0.17
3.24
u/field
—
6
34
35
304
1.16
0.32
1.9
2.1
39.67
5140.53
u/l
—
8
127
26
220
1.19
0.32
8.2
9.2
—
—
—
0
0
20
241
0.83
0.32
1.6
2.0
2.27
4.15
iu/l
—
5
100
13
102
1.28
0.30
1.1
1.2
—
—
—
0
0
12
93
1.29
0.30
1.1
1.2
—
—
—
0
0
81
747
1.09
0.29
8.7
8.1
96.31
95.80
%
0.51
76
727
17
140
1.22
0.27
2.5
3.3
2.52
2.71
mmol/l
0.13
12
95
12
95
1.27
0.26
1.2
1.1
—
—
—
0
0
9
73
1.24
0.25
1.7
1.7
—
—
—
0
0
9
75
1.20
0.25
1.1
1.1
—
—
—
0
0
15
180
0.83
0.24
1.6
1.5
186.30
767.21
e6/l
—
10
137
10
78
1.29
0.24
2.5
2.5
—
—
—
0
0
15
124
1.21
0.24
4.1
1.8
—
—
—
0
0
67
621
1.09
0.23
11.6
8.5
—
—
—
0
0
179
1864
0.95
0.23
3.9
3.8
0.00
0.17
—
5
18
224
2164
1.05
0.22
1.4
1.5
—
—
—
0
0
31
276
1.13
0.22
1.3
1.4
234.13
242.71
miu/ml
0.04
15
135
15
178
0.84
0.22
1.6
1.5
24.80
14.18
e6/l
—
10
132
151
1575
0.95
0.21
3.3
2.8
2.45
2.45
mmol/l
0.07
129
1419
0
12
0.00
0.21
0.0
1.8
—
11.60
—
0
5
0
13
0.00
0.21
0.0
1.5
—
71.08
—
0
13
19
219
0.86
0.20
1.3
1.2
—
—
—
0
0
19
164
1.16
0.20
2.8
2.5
40.63
31.92
umol/l
0.56
19
145
36
327
1.11
0.19
1.3
1.4
0.19
0.31
mg/l
—
9
137
23
203
1.14
0.19
1.1
1.3
16.01
11.19
u/l
0.42
18
159
47
434
1.09
0.19
5.7
3.1
24.11
24.32
mmol/l
0.16
47
429
15
128
1.17
0.18
1.1
1.1
—
—
—
0
0
7
60
1.17
0.18
1.6
1.3
—
—
—
0
0
8
68
1.18
0.16
1.1
1.5
1.42
1.31
nmol/l
—
8
59
13
151
0.86
0.16
1.2
1.8
—
—
—
0
0
6
76
0.79
0.15
3.2
2.5
—
—
—
0
0
83
792
1.05
0.15
3.6
4.3
5.29
14.13
ug/l
0.94
66
645
15
169
0.89
0.12
1.4
1.5
—
—
—
0
0
230
2349
0.97
0.12
7.5
6.3
—
—
—
0
0
23
210
1.10
0.12
1.3
1.5
63.15
57.73
ug/l
0.25
17
173
17
189
0.90
0.12
3.1
2.2
63.79
60.31
%
0.31
17
184
30
279
1.08
0.11
2.8
1.5
—
—
—
0
0
107
1037
1.04
0.11
1.3
1.3
—
—
—
0
0
39
413
0.94
0.10
1.3
1.3
—
—
—
0
0
10
87
1.15
0.09
1.9
1.7
21.19
27.27
ng/l
—
10
87
55
527
1.05
0.09
3.9
3.0
193.22
189.22
ng/l
0.03
50
484
65
628
1.04
0.08
1.6
1.8
3.26
3.49
mmol/l
0.83
46
451
26
244
1.07
0.08
1.5
1.3
—
—
—
0
0
6
71
0.84
0.07
1.2
1.7
12.53
11.18
%
—
6
71
7
82
0.85
0.07
1.7
1.3
5.74
6.37
mmol/l
—
7
75
7
85
0.82
0.07
2.0
1.5
—
—
—
0
0
97
947
1.03
0.07
2.8
3.3
0.76
0.76
ug/l
0.00
64
625
9
86
1.05
0.07
2.0
1.8
—
—
—
0
0
19
177
1.08
0.06
1.9
2.1
127.92
130.59
g/l
0.27
13
146
60
619
0.97
0.06
6.4
3.9
—
—
—
0
0
18
168
1.07
0.06
3.3
1.8
—
—
—
0
0
12
131
0.91
0.05
1.0
1.1
—
—
—
0
0
15
160
0.94
0.04
1.3
1.4
1.44
1.31
mm
—
9
112
36
348
1.04
0.04
1.4
1.5
1017.90
971.49
mu/l
0.14
30
288
11
119
0.92
0.04
1.4
1.2
2.00
6.31
u/ml
—
5
45
16
169
0.95
0.03
3.4
2.3
90.13
89.94
%
0.05
16
164
296
2975
0.99
0.02
3.6
3.1
—
—
—
0
0
17
162
1.05
0.02
2.8
2.9
—
—
—
0
0
22
213
1.03
0.01
1.2
1.3
608.77
483.70
mg/l
0.59
22
200
21
204
1.03
0.00
3.6
1.9
—
—
—
0
0
29
296
0.98
0.00
1.6
1.5
—
—
—
0
0
10
104
0.96
0.00
1.8
1.5
—
—
—
0
0
10
104
0.96
0.00
1.8
1.5
—
—
—
0
0
10
104
0.96
0.00
1.8
1.5
—
—
—
0
0
10
104
0.96
0.00
1.8
1.5
—
—
—
0
0
16
164
0.98
0.00
1.3
1.4
—
—
—
0
0
43
435
0.99
0.00
1.8
1.7
—
—
—
0
0
45
445
1.01
0.00
2.5
2.3
11.18
12.44
nmol/l
0.53
39
402
44
439
1.00
0.00
10.5
9.6
24.29
24.38
mmol/l
0.07
44
432
30
299
1.00
0.00
2.8
1.5
—
—
—
0
0
23
229
1.00
0.00
3.2
1.6
—
—
—
0
0
10
99
1.01
0.00
10.3
2.9
—
—
—
0
0
30
297
1.01
0.00
2.8
1.5
—
—
—
0
0
30
297
1.01
0.00
2.8
1.5
—
—
—
0
0
15
145
1.04
0.00
1.1
1.2
194.88
260.64
u/ml
—
8
80
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
188.20
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
62
0.97
-0.00
3.2
1.9
38.67
33.72
mg/l
—
6
46
0
7
0.00
-0.00
0.0
1.7
—
315.29
—
0
7
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
62
0.97
-0.00
1.5
1.1
—
126.67
—
0
9
0
9
0.00
-0.00
0.0
1.3
—
7.29
—
0
9
0
6
0.00
-0.00
0.0
7.0
—
6.67
—
0
6
7
70
1.00
-0.00
1.7
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
7
78
0.90
-0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
326.83
—
0
6
0
6
0.00
-0.00
0.0
5.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
52.00
—
0
8
8
81
0.99
-0.00
2.5
2.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
16.65
—
0
8
0
6
0.00
-0.00
0.0
3.5
—
54.50
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN and mortality.

Females

Parameter HR [95% CI] p-value
ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN 1.27 [1.11, 1.45] < 0.001
Birth year 0.991 [0.98, 1.0] 0.055

During the follow-up period (1.1.1998 — 31.12.2019), 489 out of 3292 females with ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN died.

Males

Parameter HR [95% CI] p-value
ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN 1.183 [1.01, 1.38] 0.037
Birth year 0.988 [0.98, 1.0] 0.016

During the follow-up period (1.1.1998 — 31.12.2019), 282 out of 1473 males with ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN died.

Mortality risk

Mortality risk for people of age

years, who have ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN.

N-year risk Females Males
1 0.111% 0.179%
5 0.634% 1.323%
10 1.575% 3.396%
15 3.293% 6.513%
20 5.733% 11.263%

Relationships between endpoints

Index endpoint: ALLERGIC_CONTACT_DERMA_DRUGS_CONTACT_W_SKIN – Allergic contact dermatitis due to drugs in contact with skin

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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