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Intrahepatic Cholestasis of Pregnancy (ICP) , excluding more controls

Endpoint Browser PheWeb

O15_ICP_EXMORE

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

only females

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — O26.6
  • Hospital discharge: ICD-9 — 6467
  • Cause of death: ICD-10 — O26.6
  • Cause of death: ICD-9 — 6467

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
!(O15_DELIVERY, O15_DELIVERY_PROXY)

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF3
Parent code in ICD-10
O26
Name in latin
Morbositates hepatis in graviditate, intra labores et/sive in puerperio

Similar endpoints

↥

List of similar endpoints to Intrahepatic Cholestasis of Pregnancy (ICP) , excluding more controls based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 19565 19565 -
Only index persons 19357 19357 -
Unadjusted period prevalence (%)
Whole population 0.56 0.56 -
Only index persons 0.71 0.71 -
Median age at first event (years)
Whole population - 29.97 -
Only index persons - 29.97 -

-FinnGen-

Key figures

All Female Male
Number of individuals 3003 3003 -
Unadjusted period prevalence (%) 1.07 1.07 -
Median age at first event (years) 30.53 30.53 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
3126
Matched controls
31260
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
6467A
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Liver disorders in pregnancy[HEPATOSIS GRAVIDARUM]
+∞
307.7
733
*
O26.6
ICD-10 Finland
Liver disorders in pregnancy, childbirth and the puerperium
11880.8
307.7
2475
10
A05AA02
ATC
ursodeoxycholic acid; oral
121.9
307.7
1076
134
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.1
93.4
447
1605
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
2.4
65.6
516
2361
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.4
63.6
513
2371
63900
ICD-8 Finland
Other toxaemias of pregnancy and the puerperium, Pruritus
13.0
37.4
36
28
O80.8
ICD-10 Finland
Other single spontaneous delivery
2.0
36.8
479
2631
O30.0
ICD-10 Finland
Twin pregnancy
2.9
33.7
165
592
MAC10
NOMESCO Finland
Antepartum dilatation of cervical canal
2.2
30.6
263
1233
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
1.6
28.8
765
5148
W84
ICPC
Pregnancy high risk
1.9
28.4
382
2110
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
3.3
26.9
103
320
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
1.6
26.0
776
5354
MAC01
NOMESCO Finland
Rupture of aminiotic membrane for induction of labor
2.3
25.6
196
874
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
1.5
25.3
1374
10775
L29.9
ICD-10 Finland
Pruritus, unspecified
2.7
24.3
134
512
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
3.1
22.3
95
315
MAC96
NOMESCO Finland
Other induction or advancement of labour
2.0
20.4
217
1103
S02
ICPC
Pruritus
2.3
19.2
145
643
O60
ICD-10 Finland
Preterm labour and delivery
2.0
18.8
213
1107
5742A
ICD-9 Finland
Cholelithiasis, Calculus of gallbladder without mention of cholecystitis[CHOLECYSTOLITHIASIS SINE CHOLECYSTITIDE,SINE OBSTR]
3.8
18.5
55
145
K76.9
ICD-10 Finland
Liver disease, unspecified
3.7
18.1
56
152
63998
ICD-8 Finland
Other toxaemias of pregnancy and the puerperium, Alia definitae
18.7
17.3
26
14
A10BX01
ATC
guar gum; oral
3.4
15.8
55
162
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
7.2
15.7
23
32
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
1.5
15.6
687
5068
8811
FHL
Cesarean section
1.8
15.6
260
1528
O98.4
ICD-10 Finland
Viral hepatitis complicating pregnancy, childbirth and the puerperium
7.0
15.3
23
33
XMA22
NOMESCO Finland
General examination of pregnant woman
1.5
14.8
451
3085
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
1.7
14.6
262
1572
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
1.5
14.5
446
3058
65000
ICD-8 Finland
Delivery without mention of complication, Occipital presentation
0.6
14.0
200
3391
6467X
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Liver disorders in pregnancy[HEPATOPATHIA ALIA GRAVIDARUM]
+∞
13.5
13
*
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
3.7
13.3
41
111
MAC40
NOMESCO Finland
Pharmacological induction or advancement of labor
1.8
12.9
185
1040
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.6
12.7
344
2287
6510B
ICD-9 Finland
Multiple gestation, Twin pregnancy[GEMINI, SYNNYTYKSEN AIKANA]
3.4
12.6
44
130
K83.0
ICD-10 Finland
Cholangitis
4.2
12.5
33
80
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
1.4
12.5
702
5386
O84.0
ICD-10 Finland
Multiple delivery, all spontaneous
2.9
12.1
55
191
MAA00
NOMESCO Finland
Amniocentesis
1.8
11.9
164
910
B18.2
ICD-10 Finland
Chronic viral hepatitis C
3.3
11.2
42
130
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
1.8
11.1
168
961
V230A
ICD-9 Finland
Supervision of high-risk pregnancy, Pregnancy with history of infertility
2.7
10.6
55
205
O36.6
ICD-10 Finland
Maternal care for excessive fetal growth
1.6
10.6
274
1804
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
1.3
10.4
1164
9828
ZXE00
NOMESCO Finland
One hour or less
1.3
10.2
1185
10050
O48
ICD-10 Finland
Prolonged pregnancy
0.5
10.1
100
1899
K80.5
ICD-10 Finland
Calculus of bile duct without cholangitis or cholecystitis
2.2
10.1
80
364
6510A
ICD-9 Finland
Multiple gestation, Twin pregnancy[GEMINI, RASKAUDEN AIKANA]
3.8
10.0
30
80
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
3.5
9.7
33
96
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.3
9.7
1294
11139
L29.8
ICD-10 Finland
Other pruritus
2.7
9.2
48
180
G03DA04
ATC
progesterone; systemic, rectal, vaginal
1.8
9.1
142
821
6663
FHL
Cholecystectomy and cholangiography
3.4
9.0
31
91
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.3
9.0
594
4645
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
1.5
9.0
323
2279
L04AX01
ATC
azathioprine; systemic
1.9
8.7
114
625
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
4.3
8.7
22
52
O26.0
ICD-10 Finland
Excessive weight gain in pregnancy
4.2
8.4
22
53
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
2.1
8.4
73
346
O84.2
ICD-10 Finland
Multiple delivery, all by caesarean section
2.8
8.4
41
149
Z35.4
ICD-10 Finland
Supervision of pregnancy with grand multiparity
2.3
8.3
61
270
Z87.5
ICD-10 Finland
Personal history of complications of pregnancy, childbirth and the puerperium
2.1
8.3
80
395
Z2221
NOMESCO Finland
Medical doctor
1.3
8.2
812
6703
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
1.3
8.1
745
6093
W29
ICPC
Pregnancy symptom/complaint other
1.5
8.0
220
1467
O14.9
ICD-10 Finland
Pre-eclampsia, unspecified
1.8
8.0
107
590
6488A
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Abnormal glucose tolerance
2.2
7.9
64
295
A02BC01
ATC
omeprazole; systemic
1.3
7.6
709
5802
Z35
ICD-10 Finland
Supervision of high-risk pregnancy
2.0
7.6
81
415
6480A
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Diabetes mellitus
3.1
7.6
31
102
ZXD10
NOMESCO Finland
Scheduled procedure
1.3
7.4
918
7771
O30.00
ICD-10 Finland
Twin pregnancy with separate amniotic and chorionic sacs
2.5
7.4
46
189
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
1.9
7.1
85
453
K30
ICD-10 Finland
Functional dyspepsia
1.4
7.1
348
2595
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
3.0
7.1
30
101
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
8.8
7.0
14
16
B01AB04
ATC
dalteparin; parenteral
1.7
6.9
124
746
K80.1
ICD-10 Finland
Calculus of gallbladder with other cholecystitis
2.2
6.9
55
252
O14.0
ICD-10 Finland
Mild to moderate pre-eclampsia
1.7
6.8
115
683
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
2.3
6.7
50
223
MA2XE
NOMESCO Finland
Other obstetric ultrasound examination
1.3
6.7
462
3630
O82.0
ICD-10 Finland
Delivery by elective caesarean section
1.4
6.7
315
2334
O26.9
ICD-10 Finland
Pregnancy-related condition, unspecified
2.3
6.6
49
218
A10AC01
ATC
insulin (human); parenteral
1.5
6.6
171
1127
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
1.6
6.6
142
898
G03GB02
ATC
clomifene; oral
1.7
6.5
104
607
WX321
NOMESCO Finland
Acute spinal anesthesia for delivery
1.4
6.4
289
2124
MBA00
NOMESCO Finland
Vacuum aspiration from uterus after delivery or abortion
1.6
6.3
122
752
1413
FHL
Laparoscopy and other therapeutic procedure
1.9
6.1
69
362
O61.0
ICD-10 Finland
Failed medical induction of labour
1.9
6.1
77
419
K50.9
ICD-10 Finland
Crohn disease, unspecified
2.2
6.0
46
208
O72.2
ICD-10 Finland
Delayed and secondary postpartum haemorrhage
1.7
6.0
112
683

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
966
1444
9.23
307.65
6.3
1.5
10.22
4.00
umol/l
25.10
865
1008
364
663
6.08
194.02
1.2
1.3
—
—
—
0
0
348
617
6.22
190.61
1.2
1.3
143.10
155.45
au/ml
1.02
133
136
359
670
5.92
186.35
1.2
1.3
14.08
16.35
u/ml
—
5
18
348
649
5.91
180.63
1.2
1.2
192.62
264.57
u/ml
7.32
280
428
419
1385
3.34
100.99
1.2
1.2
—
—
—
0
0
524
2942
1.94
37.83
2.6
2.4
6.33
5.97
umol/l
0.17
463
2522
1653
12785
1.62
37.47
5.5
5.3
9.77
9.44
umol/l
0.65
1567
12139
792
5102
1.74
36.38
1.6
1.6
—
—
—
0
0
202
808
2.60
33.43
1.4
1.2
847.14
1131.47
titre
—
7
34
201
814
2.57
32.42
1.5
1.2
85.45
180.12
titre
0.76
22
83
1281
9613
1.56
30.89
3.8
3.0
34.06
27.77
u/l
5.51
1224
9204
2220
19371
1.50
22.65
8.2
7.0
79.54
71.42
u/l
16.31
2132
18520
299
1663
1.88
21.59
1.7
1.9
1.36
1.36
g/l
0.04
279
1574
367
2175
1.78
21.55
2.6
2.7
10.76
10.37
g/l
1.50
338
2041
3044
29074
2.79
20.05
13.0
9.4
32.88
23.65
u/l
43.96
3013
28551
115
470
2.50
18.23
1.1
1.1
—
—
—
0
0
298
1762
1.76
17.53
2.4
2.1
0.23
0.23
g/l
0.30
281
1672
117
498
2.40
17.01
1.1
1.1
—
—
—
0
0
780
5996
1.40
13.90
4.1
3.1
98.94
99.13
%
0.09
756
5816
1028
8284
1.36
13.66
2.5
2.5
64.05
55.98
u/l
0.85
976
7820
1469
12532
1.32
13.10
9.9
8.9
0.00
0.00
e9/l
0.75
1214
10420
673
5146
1.39
12.15
1.5
1.4
641.34
583.20
titre
0.26
149
1057
83
365
2.31
11.32
1.1
1.1
1.39
1.43
g/l
0.41
75
336
1051
8686
1.32
11.23
5.4
5.5
1.03
1.05
inr
2.22
864
7226
1476
12791
1.29
10.97
6.7
5.8
0.74
0.69
%
3.25
1412
12026
1170
9840
1.30
10.92
4.9
4.2
37.04
37.32
g/l
1.13
1115
9357
2297
21114
1.33
10.89
3.6
2.9
38.06
31.78
u/l
4.50
2204
20462
1480
12844
1.29
10.82
6.7
5.8
8.13
8.04
%
0.82
1419
12153
1474
12817
1.28
10.49
6.7
5.8
2.81
2.81
%
0.04
1410
12096
60
237
2.56
10.35
1.1
1.1
—
—
—
0
0
51
186
2.77
10.28
1.3
1.2
280.77
162.31
titre
0.40
13
39
50
181
2.79
10.22
1.5
1.4
—
—
—
0
0
896
7385
1.30
9.41
1.5
1.4
2.10
2.10
g/l
0.04
605
4985
332
2339
1.47
9.29
2.6
2.3
36.26
34.78
u/l
0.17
298
1985
1518
13369
1.26
9.29
6.6
5.7
30.02
30.00
%
0.03
1462
12773
1494
13169
1.26
8.94
6.5
5.6
56.21
56.25
%
0.06
1453
12666
123
689
1.82
8.74
2.2
2.0
1.09
1.25
g/l
1.12
106
602
55
227
2.45
8.71
1.1
1.1
311.56
293.70
mg/l
0.60
48
213
1587
14114
1.25
8.69
6.6
5.7
0.51
0.51
e9/l
0.16
1423
12571
1584
14123
1.25
8.33
6.6
5.7
0.04
0.04
e9/l
0.88
1422
12562
1625
14684
1.22
7.01
6.8
5.8
0.18
0.18
e9/l
0.53
1491
13287
783
6546
1.26
6.99
2.7
2.6
0.16
0.27
e6/l
3.50
556
4654
497
3926
1.32
6.91
2.0
2.2
14.81
15.00
umol/l
0.25
466
3685
1603
14507
1.22
6.67
6.7
5.7
1.94
1.97
e9/l
0.94
1472
13249
543
4367
1.29
6.59
2.3
2.5
523.33
518.88
mosm/kgh2o
0.16
470
3817
398
3073
1.34
6.48
2.1
2.3
24.38
24.40
%
0.01
375
2856
2002
18567
1.22
6.32
3.7
3.4
57.99
64.51
ug/l
3.39
1929
17823
89
504
1.79
6.21
1.6
1.6
0.60
0.62
g/l
0.06
72
392
1028
8956
1.22
6.14
1.4
1.4
1.03
1.47
u/ml
1.57
315
2872
445
3518
1.31
6.12
2.1
2.2
2.50
2.51
g/l
0.11
410
3248
385
3001
1.32
5.86
1.2
1.2
—
—
—
0
0
2633
25236
1.27
5.66
14.9
12.9
13.32
13.29
%
0.85
2611
24952
884
7668
1.21
5.38
2.8
2.8
33.21
68.88
e6/l
1.05
642
5694
1697
15624
1.19
5.32
8.5
7.8
3.82
3.93
e9/l
1.39
1510
13778
598
4997
1.24
5.20
3.2
2.5
95.80
97.47
ug/g
0.05
479
3981
353
2772
1.31
5.10
3.4
3.2
—
—
—
0
0
85
506
1.70
5.05
4.8
3.5
917.93
423.41
u/ml
0.31
76
436
776
6688
1.21
4.99
1.4
1.3
8.47
8.06
u/ml
0.08
320
2981
1235
11106
1.19
4.97
2.2
1.9
—
—
—
0
0
835
7256
1.21
4.92
1.4
1.4
24.26
23.80
iu/ml
0.04
246
2201
1408
12826
1.18
4.81
2.7
2.4
75.30
74.34
nmol/l
0.72
1340
12231
34
151
2.27
4.72
3.2
3.2
8.67
8.52
mg/l
0.04
27
116
816
7099
1.20
4.72
2.4
2.1
2.39
2.50
mg/l
1.06
723
6259
66
373
1.79
4.72
4.1
3.1
—
—
—
0
0
736
6350
1.21
4.64
2.2
2.1
294.94
291.86
umol/l
0.47
671
5861
1104
9926
1.17
4.29
3.4
3.3
68.00
64.52
e6/l
0.07
725
6378
796
6978
1.19
4.16
1.9
1.7
0.97
0.83
mg/l
1.06
601
5281
2518
24207
1.21
4.13
4.5
4.3
36.52
36.63
mmol/mol
0.33
2426
23341
355
2869
1.27
4.11
1.5
1.4
—
—
—
0
0
2756
26756
1.25
4.02
10.6
9.8
139.65
139.62
mmol/l
0.30
2711
26275
614
5279
1.20
3.97
2.4
2.4
9.15
8.60
e6/l
0.14
549
4731
429
3560
1.24
3.94
1.2
1.2
—
—
—
0
0
368
3004
1.26
3.92
2.2
1.9
28.75
28.63
s
0.17
351
2899
660
5736
1.19
3.77
1.6
1.5
20.78
20.51
nmol/l
0.21
603
5169
2794
27201
1.26
3.75
6.1
5.8
1.63
1.67
mu/l
0.70
2696
26313
1054
9521
1.16
3.74
1.8
1.8
100.80
99.88
pmol/l
0.25
569
5361
424
3538
1.23
3.70
2.4
2.4
5.41
5.06
e6/l
0.13
188
1646
44
238
1.86
3.69
2.5
2.3
24.00
26.25
mg/l
0.15
31
160
143
1032
1.40
3.64
1.3
1.3
—
—
—
0
0
50
283
1.78
3.64
1.1
1.2
—
—
—
0
0
2547
24585
1.19
3.63
5.3
5.0
14.26
14.20
pmol/l
0.68
2428
23608
158
1165
1.38
3.55
1.5
1.7
0.24
0.27
mg/l
0.26
55
479
165
1227
1.36
3.52
6.4
7.0
6.80
6.59
mmol/l
0.21
157
1193
2755
26810
1.23
3.51
10.8
9.9
3.88
3.89
mmol/l
1.07
2707
26254
115
813
1.43
3.31
2.3
1.5
7.54
12.22
iu/ml
—
5
23
376
3140
1.22
3.27
1.9
1.8
—
—
—
0
0
701
6193
1.17
3.26
3.4
3.4
7.39
7.40
ph
0.58
513
4371
210
1639
1.30
3.24
2.0
2.6
1.64
1.70
%
0.51
185
1490
1009
9164
1.15
3.23
5.2
5.0
1.22
1.22
mmol/l
0.57
964
8615
137
1004
1.38
3.22
2.6
2.1
4.02
3.67
g/l
1.86
124
945
1155
10600
1.14
3.16
5.4
5.5
1.22
1.22
mmol/l
0.44
1000
9232
65
412
1.59
3.16
1.4
1.3
—
—
—
0
0
103
723
1.44
3.11
2.0
1.3
—
—
—
0
0
57
354
1.62
3.02
3.3
2.4
2.15
2.02
mmol/l
0.15
30
206
1084
9939
1.14
2.97
3.0
2.8
0.03
0.04
estimate
0.23
393
3092
1292
11981
1.13
2.97
2.2
2.2
—
—
—
0
0
450
3869
1.19
2.89
2.4
2.3
2.21
0.99
e6/l
0.49
211
1984
324
2701
1.22
2.88
3.1
3.6
4.58
4.60
pmol/l
0.10
299
2477
1175
10848
1.13
2.87
1.8
1.7
1.19
1.31
mmol/l
6.02
1034
9647
59
379
1.57
2.75
2.6
2.5
—
—
—
0
0
870
7903
1.14
2.71
5.4
5.0
—
—
—
0
0
207
1658
1.27
2.66
3.1
3.2
1.22
1.23
mmol/l
1.39
183
1428
177
1392
1.29
2.63
1.8
1.9
0.04
0.02
estimate
0.18
69
575
2111
20259
1.13
2.60
4.6
4.1
696.14
1659.19
e6/l
0.62
21
213
377
3227
1.19
2.56
3.1
3.1
0.84
0.83
mmol/l
0.57
362
3079
924
8459
1.13
2.52
2.4
2.3
—
—
—
0
0
23
115
2.01
2.50
1.3
1.6
28.61
30.57
umol/l
0.45
23
104
270
2246
1.22
2.48
1.2
1.2
—
—
—
0
0
76
530
1.44
2.44
2.4
2.1
—
—
—
0
0
255
2115
1.22
2.42
4.3
4.1
0.64
0.68
%
0.10
58
461
314
2660
1.20
2.40
1.4
1.3
194.13
139.97
u/ml
0.34
303
2498
1593
15085
1.11
2.38
4.4
4.0
6.09
6.11
mmol/l
0.12
1435
13397
1751
16680
1.11
2.32
3.6
3.4
2.88
4.01
estimate
0.14
451
3686
56
372
1.51
2.30
1.4
1.3
1183.33
1015.00
titre
0.45
12
60
745
6766
1.13
2.29
3.8
3.2
7.78
7.70
mmol/l
0.18
657
6002
265
2222
1.21
2.27
5.1
4.4
0.08
0.45
%
0.68
50
403
82
589
1.40
2.26
1.1
1.0
—
—
—
0
0
265
2224
1.21
2.25
4.8
4.2
1.11
0.99
%
0.17
56
491
188
1525
1.25
2.21
2.1
2.1
7.16
6.96
iu/ml
0.03
46
374
50
328
1.53
2.19
1.2
1.1
16.76
15.82
u/ml
0.09
26
159
2938
28962
1.24
2.18
13.2
11.8
65.21
65.23
umol/l
0.03
2923
28706
702
6372
1.13
2.17
1.9
1.9
114.74
133.61
u/l
0.81
677
6120
2997
29613
1.29
2.17
11.3
10.1
—
—
—
0
0
256
2151
1.21
2.15
4.9
4.3
0.23
0.14
%
0.34
48
417
28
159
1.77
2.13
1.5
2.3
0.86
0.84
%
0.09
14
90
159
1273
1.26
2.11
2.0
2.3
2.92
4.01
iu/l
2.31
70
591
99
744
1.34
2.10
1.2
1.1
13.45
14.99
au/ml
0.11
33
229
125
972
1.30
2.09
1.2
1.3
60.59
38.33
u/ml
—
7
86
135
1062
1.28
2.07
1.3
1.3
7.40
5.51
u/ml
—
9
97
143
1135
1.27
2.04
2.1
2.7
66.48
72.47
e9/l
1.42
92
813
273
2323
1.19
2.02
1.3
1.3
17.66
40.79
au/ml
2.81
11
135
123
961
1.29
1.99
1.2
1.1
—
—
—
0
0
325
2811
1.17
1.99
1.8
1.9
0.07
0.04
estimate
0.22
76
690
88
656
1.35
1.98
3.4
3.3
57.77
58.09
%
0.09
88
656
60
846
0.70
1.98
6.6
6.6
—
—
—
0
0
553
4976
1.14
1.96
3.3
3.4
—
—
—
0
0
27
156
1.74
1.96
1.3
1.3
—
—
—
0
0
1753
16782
1.10
1.96
3.7
3.5
0.00
0.30
estimate
0.56
445
3628
134
1063
1.27
1.94
1.3
1.4
6.86
6.80
u/ml
0.01
14
163
289
2483
1.18
1.92
2.4
2.4
17.03
19.46
au/ml
0.36
30
373
604
5472
1.13
1.92
4.1
3.9
10.03
10.17
mg/mmol
0.03
377
3345
338
2945
1.17
1.90
2.0
2.2
369.94
374.02
nmol/l
0.16
318
2777
193
1602
1.22
1.87
1.2
1.3
0.27
0.91
u/ml
1.73
12
114
531
4785
1.13
1.85
1.7
1.6
16807153.46
46123824.33
pmol/l
0.90
476
4295
49
334
1.47
1.84
1.1
1.1
7.79
8.52
iu/ml
0.09
15
97
419
3719
1.15
1.83
2.5
2.4
289.96
396.38
ng/l
0.89
329
2971
15
73
2.06
1.80
1.3
2.5
11870.60
62.27
mg/l
—
10
52
199
1667
1.21
1.77
2.6
2.0
—
—
—
0
0
1022
9578
1.10
1.73
2.8
2.6
0.42
0.05
0.84
12
128
268
2317
1.17
1.68
4.3
4.9
1.05
1.04
mmol/l
0.35
257
2150
107
844
1.28
1.66
12.1
9.5
16.36
16.16
%
0.34
101
802
113
898
1.27
1.65
1.8
2.2
51.45
68.48
ng/l
0.91
97
803
51
359
1.43
1.65
1.4
1.6
36.04
24.86
ng/l
0.48
51
359
144
1177
1.23
1.65
1.3
1.3
84.22
26.54
u/ml
—
6
78
1720
16531
1.09
1.63
3.6
3.4
0.00
0.00
estimate
2.09
454
3683
80
609
1.32
1.62
2.6
2.4
1.74
1.45
index
0.10
46
317
24
143
1.68
1.61
1.8
1.6
1.79
1.94
umol/l
0.53
24
130
828
7708
1.10
1.60
4.4
3.9
—
—
—
0
0
1367
13023
1.09
1.58
3.2
3.1
6.21
6.24
ph
0.42
798
7677
592
5421
1.11
1.57
3.6
3.3
63.56
59.53
mg/l
0.14
381
3331
835
7782
1.10
1.57
2.5
2.4
17.98
33.80
ng/l
0.57
307
2986
114
915
1.26
1.55
1.2
1.1
—
—
—
0
0
859
8023
1.10
1.54
2.8
2.9
2.34
2.34
mmol/l
0.18
810
7536
46
323
1.43
1.53
1.2
1.4
—
—
—
0
0
951
8927
1.09
1.53
3.5
3.5
0.01
0.00
estimate
0.17
442
3556
114
917
1.25
1.53
1.2
1.1
—
—
—
0
0
454
4110
1.12
1.48
2.8
2.4
6277.65
7453.96
u/l
0.38
212
1919
42
293
1.44
1.46
1.4
1.2
—
—
—
0
0
129
1059
1.23
1.45
2.4
2.1
0.22
0.23
g/l
0.12
124
1010
418
3773
1.12
1.44
1.2
1.2
—
—
—
0
0
2602
25545
1.11
1.42
3.8
3.7
5.51
5.52
mmol/l
0.31
2475
24452
18
104
1.74
1.36
1.1
1.2
—
—
—
0
0
39
275
1.42
1.30
2.4
2.8
9.05
122.09
ug/min
3.53
30
185
83
659
1.27
1.28
1.4
1.3
320.27
325.75
ug/g
0.09
41
316
166
1416
1.18
1.28
9.9
6.6
1.24
1.21
mmol/l
0.17
166
1389
179
1538
1.17
1.27
4.4
2.6
—
—
—
0
0
44
319
1.38
1.27
1.4
1.1
—
—
—
0
0
27
178
1.52
1.26
1.6
2.5
31.26
32.06
pg
0.38
27
178
19
115
1.66
1.24
1.1
1.1
—
—
—
0
0
348
3139
1.12
1.24
1.4
1.4
—
—
—
0
0
62
477
1.31
1.23
2.2
2.0
5.16
5.43
mmol/24h
0.35
57
438
11
56
1.97
1.22
3.0
4.9
—
—
—
0
0
10
49
2.04
1.22
2.8
2.9
0.63
0.60
mmol/l
—
10
49
412
3757
1.11
1.21
2.4
2.5
3.84
4.24
e9/l
1.92
373
3446
202
1762
1.16
1.20
1.1
1.1
—
—
—
0
0
24
156
1.54
1.20
1.7
1.8
2.42
2.65
mg/l
0.32
24
151
340
3070
1.12
1.19
1.3
1.4
—
—
—
0
0
40
289
1.39
1.19
1.2
1.1
—
—
—
0
0
75
595
1.27
1.19
1.3
1.2
—
—
—
0
0
45
332
1.36
1.18
1.2
1.4
6.53
6.34
g/l
0.17
27
238
45
332
1.36
1.18
1.2
1.4
0.33
0.37
g/l
0.45
29
235
45
332
1.36
1.18
1.2
1.4
3.46
3.02
g/l
1.02
29
236
222
1952
1.15
1.18
2.5
2.0
—
—
—
0
0
126
1488
0.84
1.14
1.3
1.2
11.68
11.78
u/l
0.03
107
1263
305
2746
1.12
1.13
1.7
1.6
1148.47
1203.78
nmol/l
0.54
248
2251
143
1220
1.18
1.13
2.2
2.5
1.02
1.02
ratio
0.60
125
1045
140
1194
1.18
1.12
2.4
2.3
67.31
67.57
g/l
0.19
132
1123
9
164
0.55
1.08
1.6
1.1
—
—
—
0
0
1025
9777
1.07
1.07
2.0
1.8
—
—
—
0
0
17
105
1.62
1.06
1.2
1.1
—
0.13
g/l
—
0
5
10
53
1.89
1.01
1.1
1.6
—
—
—
0
0
135
1162
1.17
0.99
2.2
1.7
20.54
20.01
s
0.42
119
958
395
3639
1.10
0.98
1.3
1.3
162.73
148.13
u/ml
0.31
161
1527
0
31
0.00
0.96
0.0
3.5
—
1671.94
—
0
31
204
1814
1.13
0.96
1.4
1.4
—
—
—
0
0
634
5969
1.08
0.94
2.3
2.1
—
—
—
0
0
18
270
0.66
0.94
1.0
1.1
—
—
—
0
0
43
329
1.31
0.94
1.1
1.2
—
—
—
0
0
37
278
1.33
0.92
1.2
1.2
69.49
71.00
ug/l
0.06
37
278
74
608
1.22
0.91
1.4
1.2
1.97
4.33
u/ml
3.12
33
252
20
134
1.50
0.91
1.2
1.1
—
—
—
0
0
277
2519
1.11
0.90
2.0
1.9
—
—
—
0
0
342
3149
1.10
0.87
1.6
1.6
—
—
—
0
0
96
814
1.19
0.87
1.1
1.1
1.73
4.83
u/ml
2.73
44
353
6
30
2.00
0.87
1.2
1.2
—
—
—
0
0
26
357
0.73
0.86
1.5
1.4
470.81
663.19
pmol/l
0.28
26
316
1338
12948
1.06
0.85
3.4
3.2
0.06
0.20
estimate
0.41
384
3108
49
388
1.27
0.85
1.2
1.5
—
2537.14
—
0
7
21
145
1.45
0.84
1.1
1.2
—
—
—
0
0
6
31
1.94
0.84
1.2
1.1
—
—
—
0
0
6
31
1.94
0.84
2.2
2.2
31.50
20.82
mg/l
—
6
31
25
179
1.40
0.84
1.1
1.1
—
—
—
0
0
124
1422
0.87
0.83
1.4
1.3
3.19
3.91
ug/l
1.06
116
1323
84
707
1.19
0.83
2.3
2.1
10.39
10.38
mg/l
0.00
79
677
28
205
1.37
0.83
3.0
2.8
0.79
1.39
g/24h
1.28
17
126
109
940
1.17
0.82
1.1
1.1
0.98
1.69
u/ml
0.75
52
449
41
320
1.28
0.80
1.9
1.4
—
—
—
0
0
104
896
1.17
0.80
3.9
2.6
—
—
—
0
0
23
164
1.41
0.79
1.1
1.1
12.88
8.03
u/ml
—
5
34
23
164
1.41
0.79
1.3
1.8
0.82
0.62
mmol/l
0.13
23
154
53
428
1.24
0.79
1.9
1.6
14512.31
6933.45
e6/l
0.44
35
305
781
7455
1.06
0.79
1.6
1.6
991.12
1004.36
mu/l
0.15
650
6359
0
25
0.00
0.79
0.0
1.0
—
—
—
0
0
70
583
1.21
0.79
1.2
1.1
—
—
—
0
0
100
860
1.17
0.79
2.4
2.1
—
—
—
0
0
157
1397
1.13
0.77
2.8
3.0
70.84
72.56
ng/l
0.12
147
1257
59
484
1.22
0.77
2.7
1.9
106.64
234.96
ug/l
1.71
48
428
188
1693
1.12
0.76
1.1
1.1
0.58
0.60
ratio
0.21
27
165
5
24
2.09
0.74
1.4
1.1
—
—
—
0
0
39
307
1.27
0.73
1.2
1.2
0.62
0.69
ratio
0.61
16
184
54
442
1.23
0.73
2.3
2.1
—
—
—
0
0
41
325
1.27
0.73
1.4
1.4
—
—
—
0
0
130
1148
1.14
0.73
1.1
1.1
7.72
6.10
eliau/ml
0.09
19
194
5
27
1.85
0.68
1.4
2.9
—
—
—
0
0
12
77
1.56
0.68
1.0
1.2
—
—
—
0
0
420
3949
1.07
0.68
2.1
2.2
2.41
2.41
mmol/l
0.72
376
3520
1048
10131
1.05
0.68
2.2
1.9
—
—
—
0
0
91
789
1.16
0.67
1.7
1.5
6.33
6.55
mmol/l
0.56
78
726
90
1035
0.87
0.67
1.6
1.8
10.69
4.66
ug/l
0.86
81
914
28
214
1.31
0.66
1.7
1.7
50.33
45.27
%
0.25
18
121
452
4266
1.07
0.66
1.3
1.3
26.18
25.90
iu/l
0.06
399
3723
77
660
1.17
0.66
4.0
5.1
1.75
1.74
%
0.03
71
616
79
679
1.17
0.66
1.2
1.3
—
—
—
0
0
18
248
0.72
0.65
1.4
1.1
9.44
9.16
mm/h
0.05
18
248
5
29
1.73
0.64
1.0
1.1
—
—
—
0
0
20
146
1.37
0.63
1.8
1.6
0.00
0.02
estimate
0.50
20
146
70
598
1.17
0.63
4.0
5.5
0.89
0.92
%
0.27
64
559
695
7250
0.95
0.63
3.5
3.4
1.50
0.24
—
6
45
98
860
1.14
0.63
1.1
1.1
0.84
4.71
u/ml
4.26
47
417
2854
28333
1.08
0.63
12.5
11.0
17.03
18.30
mg/l
1.56
2348
23105
128
1144
1.12
0.62
1.1
1.1
1.90
2.12
u/ml
0.11
70
586
22
164
1.34
0.62
2.2
1.5
42.58
46.24
%
0.16
16
88
0
20
0.00
0.60
0.0
1.1
—
0.05
—
0
9
0
20
0.00
0.60
0.0
3.7
—
6.41
—
0
20
0
21
0.00
0.60
0.0
1.1
—
24.86
—
0
7
24
311
0.77
0.59
1.1
1.1
1720.71
1481.86
miu/ml
0.62
24
311
37
299
1.24
0.59
1.2
1.2
0.23
0.81
u/ml
1.18
19
149
35
281
1.25
0.59
1.0
1.0
—
—
—
0
0
233
2157
1.09
0.58
2.5
1.8
—
—
—
0
0
411
3887
1.07
0.58
1.5
1.5
—
—
—
0
0
1270
12373
1.04
0.58
1.9
1.9
—
—
—
0
0
8
54
1.48
0.57
1.8
1.7
—
—
—
0
0
2736
27137
1.07
0.57
4.3
4.2
2.84
2.89
mmol/l
3.43
2644
26231
56
657
0.85
0.56
1.9
2.5
—
—
—
0
0
133
1203
1.11
0.55
2.0
2.6
4.82
4.59
kpa
0.45
128
1164
233
2165
1.08
0.54
2.6
2.0
—
—
—
0
0
2723
27011
1.06
0.54
4.1
4.0
4.76
4.84
mmol/l
5.20
2637
26213
231
2148
1.08
0.53
2.5
2.0
—
—
—
0
0
2513
25375
0.95
0.53
15.3
13.4
331.66
332.24
g/l
2.93
2499
25243
56
652
0.86
0.52
1.4
1.5
55.42
34.98
nmol/l
0.48
48
596
10
66
1.52
0.52
2.0
1.3
6.02
8.88
mmol/l
—
10
66
12
169
0.71
0.52
1.8
2.9
0.98
0.85
e9/l
0.61
12
163
14
100
1.40
0.51
1.1
1.1
16.57
34.90
iu/ml
1.32
14
100
17
126
1.35
0.51
1.2
1.5
12.21
13.44
pmol/l
0.57
17
107
205
1904
1.08
0.50
1.1
1.1
—
—
—
0
0
103
925
1.12
0.50
1.2
1.3
—
—
—
0
0
21
162
1.30
0.50
1.3
1.8
1.58
2.63
nmol/l
0.63
14
122
263
2468
1.07
0.49
1.6
1.5
370.70
278.00
mu/l
0.37
234
2193
18
136
1.33
0.49
1.1
1.3
72.90
88.78
nmol/24h
0.65
18
136
413
3933
1.06
0.49
1.6
1.5
1.22
1.16
ratio
0.68
253
2403
7
46
1.52
0.48
2.1
2.8
57.79
47.78
%
—
7
46
2714
26940
1.06
0.47
4.0
3.9
1.54
1.54
mmol/l
0.07
2629
26055
115
1043
1.11
0.47
1.8
1.6
7.64
7.56
mmol/l
0.17
108
1007
435
4154
1.05
0.47
1.6
1.5
67.12
62.07
ug/l
1.24
347
3521
12
85
1.41
0.46
1.1
1.2
0.01
0.05
u/ml
2.73
12
85
125
1141
1.10
0.46
1.2
1.2
—
—
—
0
0
37
311
1.19
0.44
1.5
1.2
—
—
nmol/l
—
0
0
7
51
1.37
0.44
1.0
1.4
—
—
—
0
0
13
95
1.37
0.43
1.2
1.2
—
—
—
0
0
152
1405
1.09
0.43
1.6
1.7
7.78
10.74
u/ml
1.09
44
406
518
4985
1.05
0.42
1.5
1.5
—
—
—
0
0
44
378
1.17
0.42
1.1
1.1
180.22
198.03
mg/l
0.78
38
338
17
131
1.30
0.42
1.2
1.5
118.76
123.42
nmol/l
0.22
17
131
266
2516
1.06
0.41
3.2
3.5
33.38
32.71
%
0.48
200
1992
5
33
1.52
0.41
1.6
2.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
704.19
—
0
15
0
16
0.00
0.41
0.0
1.0
—
0.04
—
0
6
32
268
1.20
0.40
4.2
3.8
3.20
2.11
ratio
0.29
16
153
108
987
1.10
0.40
1.1
1.1
3.54
5.48
u/ml
0.88
52
523
80
720
1.11
0.40
1.1
1.1
0.05
0.29
u/ml
0.80
24
202
281
2669
1.06
0.39
2.2
2.3
6.18
6.21
ph
0.24
183
1642
28
233
1.20
0.38
1.9
1.8
12.82
22.30
mg/l
1.32
11
103
20
160
1.25
0.38
1.3
1.4
—
—
—
0
0
45
392
1.15
0.37
2.0
2.8
0.87
0.88
nmol/l
0.05
36
346
85
772
1.10
0.37
1.1
1.2
—
—
—
0
0
9
69
1.31
0.37
2.2
1.4
—
—
—
0
0
237
2248
1.06
0.35
2.8
2.4
25.37
34.45
u/ml
0.80
232
2183
107
986
1.09
0.35
2.1
2.2
—
—
—
0
0
761
7416
1.03
0.35
2.1
1.9
—
—
—
0
0
2550
25321
1.04
0.35
3.4
3.4
1.08
1.16
mmol/l
9.29
2469
24428
165
1549
1.07
0.34
5.1
3.8
33.57
37.18
ug/l
0.03
116
1101
25
209
1.20
0.34
1.1
1.4
80.61
67.57
mmol/l
0.56
18
174
101
932
1.09
0.33
1.1
1.1
1.03
1.19
u/ml
0.10
42
376
47
530
0.89
0.33
1.9
2.3
24.38
24.54
mmol/l
0.22
41
492
6
86
0.70
0.33
1.2
1.3
5.52
5.41
mmol/l
—
6
86
35
303
1.16
0.32
1.3
1.2
0.17
0.15
nmol/l
0.34
27
222
1229
12082
1.03
0.32
2.2
1.9
—
—
—
0
0
7
52
1.35
0.31
4.1
3.6
0.13
0.20
%
—
7
52
7
53
1.32
0.30
2.3
2.0
—
—
—
0
0
24
283
0.85
0.30
1.5
1.6
—
—
—
0
0
24
283
0.85
0.30
1.5
1.6
—
—
—
0
0
24
283
0.85
0.30
1.5
1.6
—
—
—
0
0
24
283
0.85
0.30
1.5
1.6
—
—
—
0
0
44
495
0.89
0.30
2.5
1.9
2.02
1.62
ug/l
0.14
35
451
37
324
1.14
0.30
4.6
7.6
11.28
10.93
mmol/l
0.31
32
290
37
324
1.14
0.30
4.6
7.6
105.84
105.59
mmol/l
0.09
32
290
235
2243
1.05
0.30
1.4
1.4
226.06
237.43
miu/ml
0.19
118
1160
48
536
0.89
0.30
1.0
1.2
2.33
20927.75
iu/ml
—
6
128
44
391
1.13
0.30
1.1
1.2
42.54
35.56
mg/l
0.28
34
329
107
996
1.08
0.29
1.7
2.6
7.41
7.42
ph
0.18
82
835
81
745
1.09
0.29
1.3
1.4
986.23
2064.40
e6/l
0.40
60
600
7
56
1.25
0.29
1.0
1.2
—
—
—
0
0
7
56
1.25
0.29
1.0
1.0
—
—
—
0
0
13
103
1.26
0.28
1.2
1.2
25.92
27.22
s
0.91
13
103
8
62
1.29
0.28
1.1
1.2
—
—
—
0
0
8
62
1.29
0.28
1.1
1.2
—
—
—
0
0
8
62
1.29
0.28
1.1
1.2
—
—
—
0
0
82
758
1.08
0.27
3.0
3.1
177.91
424.37
mg/l
2.18
35
313
139
1311
1.06
0.27
12.4
7.9
—
—
—
0
0
8
64
1.25
0.27
1.9
2.5
153.88
160.81
nmol/l
—
8
58
225
2154
1.05
0.27
1.8
1.9
—
—
—
0
0
8
66
1.21
0.26
2.8
2.7
509.25
513.22
min
—
8
55
8
67
1.19
0.26
1.3
2.3
42.91
41.66
g/l
—
8
67
23
197
1.17
0.25
2.2
1.9
—
—
—
0
0
378
3665
1.04
0.25
2.9
2.6
277.08
239.32
ng/l
0.09
162
1676
207
1983
1.05
0.24
1.3
1.2
—
—
—
0
0
36
321
1.12
0.24
4.1
3.9
36.88
46.15
mg/l
0.29
31
282
1393
13765
1.02
0.23
2.6
2.4
—
—
—
0
0
90
844
1.07
0.22
1.5
1.6
352.68
359.67
mu/l
0.06
71
686
32
358
0.89
0.22
1.0
1.0
0.33
1.91
u/ml
—
6
113
5
40
1.25
0.22
1.8
1.6
—
—
—
0
0
16
189
0.85
0.22
1.4
1.5
0.42
0.49
e9/l
1.12
16
189
403
3924
1.03
0.22
1.6
1.5
3.40
3.44
mmol/l
0.32
279
2580
5
41
1.22
0.22
3.6
1.1
42.50
37.59
%
—
5
35
17
144
1.18
0.22
1.1
1.1
—
—
—
0
0
3090
30861
1.11
0.22
19.7
17.1
266.94
267.80
e9/l
0.35
3060
30557
39
353
1.11
0.21
2.3
2.9
—
—
—
0
0
147
1403
1.05
0.21
2.7
3.1
1.42
1.67
mmol/l
0.38
122
1224
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
27.66
—
0
10
21
182
1.15
0.21
2.1
2.2
—
—
—
0
0
16
188
0.85
0.21
1.3
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
3.1
—
39.25
—
0
12
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
31
277
1.12
0.21
1.8
2.0
18.60
20.40
nmol/l
0.50
31
268
25
220
1.14
0.21
1.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
82.91
—
0
7
17
145
1.17
0.20
4.9
2.1
—
—
—
0
0
6
49
1.22
0.20
1.2
1.3
56.67
61.78
ug/l
—
6
49
289
2977
0.97
0.20
1.7
1.7
—
—
—
0
0
78
733
1.07
0.19
1.2
1.3
5.06
22.43
e6/l
3.04
52
555
35
317
1.11
0.19
1.1
1.1
1.08
1.05
ratio
0.69
30
258
19
165
1.15
0.19
2.2
2.7
10.40
16.03
index
—
10
98
89
842
1.06
0.18
1.1
1.3
418.70
454.42
mg/l
0.40
84
807
7
58
1.21
0.18
2.0
1.9
—
—
—
0
0
18
206
0.87
0.18
6.1
7.2
13.10
107.45
ug/l
0.60
11
135
1561
15480
1.02
0.17
2.9
2.7
—
—
estimate
—
0
0
10
82
1.22
0.17
2.9
1.6
—
—
—
0
0
10
82
1.22
0.17
1.1
1.0
64.74
73.30
ug/l
—
10
71
5
67
0.75
0.17
1.0
1.0
—
—
—
0
0
172
1661
1.04
0.16
10.7
7.7
5.00
4.98
kpa
0.13
165
1604
512
5027
1.02
0.16
1.8
1.7
3.19
3.27
ratio
0.87
390
3626
147
1415
1.04
0.16
11.8
8.4
121.54
121.05
g/l
0.12
140
1378
173
1671
1.04
0.16
10.6
7.8
7.42
7.42
ph
0.13
84
929
172
1662
1.04
0.16
10.7
7.7
14.49
14.14
kpa
0.29
165
1602
35
321
1.09
0.16
4.2
3.9
20.86
28.30
mg/l
1.17
30
283
50
467
1.07
0.15
1.3
1.5
—
2.71
—
0
7
106
1107
0.96
0.15
1.8
2.0
—
—
—
0
0
6
76
0.79
0.15
1.2
2.2
6.00
7.17
mmol/l
—
6
76
6
79
0.76
0.15
2.7
1.5
—
—
—
0
0
6
79
0.76
0.15
1.0
1.3
—
—
—
0
0
9
79
1.14
0.15
2.4
1.5
—
—
—
0
0
30
274
1.10
0.15
1.1
1.1
—
—
—
0
0
19
213
0.89
0.15
1.2
1.5
0.59
1.21
promille
1.41
14
159
9
82
1.10
0.15
1.1
1.1
—
—
—
0
0
727
7364
0.98
0.14
3.4
3.4
1.02
1.43
kg/l
0.80
498
4851
51
479
1.07
0.14
1.9
2.1
132.33
131.24
g/l
0.19
43
396
3090
30872
1.08
0.14
19.6
17.0
89.91
90.19
fl
3.52
3082
30772
3090
30872
1.08
0.14
19.6
17.0
29.90
30.05
pg
6.14
3082
30774
17
191
0.89
0.13
1.0
1.0
—
—
—
0
0
88
919
0.96
0.13
4.7
7.1
24.30
24.11
mmol/l
0.25
80
877
39
418
0.93
0.13
1.5
1.4
—
—
—
0
0
3090
30873
1.08
0.13
20.1
17.3
39.73
40.55
%
1.95
3081
30753
3090
30873
1.08
0.13
19.7
17.1
6.68
6.76
e9/l
1.06
3058
30529
288
2820
1.02
0.13
1.6
1.5
61.70
60.24
ug/l
0.23
288
2820
10
117
0.85
0.13
1.0
1.1
—
—
—
0
0
9
106
0.85
0.13
2.1
2.0
—
—
—
0
0
139
1346
1.03
0.13
2.0
1.7
—
—
—
0
0
169
1643
1.03
0.12
10.7
7.7
0.08
0.67
mmol/l
1.34
135
1296
11
127
0.87
0.12
1.2
1.9
106.73
106.09
mmol/l
0.53
11
127
11
127
0.87
0.12
1.2
1.9
4.00
3.92
mmol/l
0.33
11
127
17
152
1.12
0.12
1.2
1.3
153.17
142.08
mmol/24h
0.27
17
152
3090
30875
1.07
0.12
19.7
17.1
4.46
4.46
e12/l
0.03
3058
30552
149
1448
1.03
0.11
11.3
8.1
96.57
96.70
%
0.08
141
1397
48
507
0.95
0.11
3.3
3.3
27.44
20.73
mg/l
0.54
32
336
29
269
1.08
0.11
1.2
1.1
111.66
120.33
pmol/l
0.50
29
269
13
115
1.13
0.10
1.4
1.7
121.62
88.61
ng/l
0.25
13
115
16
177
0.90
0.10
1.3
3.7
—
—
—
0
0
20
183
1.09
0.10
1.8
2.5
—
—
—
0
0
58
555
1.05
0.10
1.5
1.3
1.27
1.27
nmol/l
0.00
47
484
650
6435
1.01
0.10
1.6
1.6
—
—
—
0
0
54
565
0.95
0.10
3.7
5.4
1.04
1.17
mmol/l
1.15
47
498
5
45
1.11
0.09
1.0
1.0
0.02
0.03
u/ml
—
5
45
18
164
1.10
0.09
1.3
2.3
—
—
—
0
0
107
1039
1.03
0.09
1.7
2.6
4.98
5.08
kpa
0.77
100
1000
10
87
1.15
0.09
1.0
1.2
—
—
—
0
0
16
176
0.91
0.09
1.6
1.7
1.17
2.04
u/field
—
6
102
20
184
1.09
0.09
1.4
1.3
69.00
67.07
umol/l
0.20
20
184
11
124
0.89
0.09
1.2
1.8
1.21
1.21
mmol/l
0.39
11
124
6
55
1.09
0.09
1.0
1.6
—
—
—
0
0
6
56
1.07
0.08
1.8
1.5
15.45
62.41
u/l
—
6
51
19
206
0.92
0.08
1.4
1.6
—
—
—
0
0
443
4481
0.99
0.08
1.3
1.3
—
—
—
0
0
6
57
1.05
0.08
1.2
1.2
—
—
—
0
0
91
937
0.97
0.08
15.9
9.2
1.14
1.36
%
1.54
91
932
3090
30881
1.05
0.08
19.8
17.2
132.40
133.15
g/l
4.11
3081
30779
5
65
0.77
0.08
1.2
1.1
—
—
—
0
0
13
117
1.11
0.08
3.4
2.8
—
—
—
0
0
17
157
1.08
0.07
1.6
2.6
—
—
—
0
0
40
383
1.04
0.07
3.5
4.6
37.30
81.38
u/ml
—
9
141
9
87
1.03
0.07
1.0
1.0
—
—
—
0
0
9
87
1.03
0.07
1.0
1.0
—
—
—
0
0
9
87
1.03
0.07
1.0
1.0
—
—
—
0
0
14
128
1.09
0.06
1.1
1.1
—
—
—
0
0
8
95
0.84
0.06
1.3
1.2
—
—
—
0
0
10
111
0.90
0.06
3.5
2.3
1.76
1.64
nmol/l
—
10
92
149
1465
1.02
0.06
2.7
3.0
7.37
7.37
ph
0.29
77
786
132
1297
1.02
0.05
1.4
1.5
0.36
0.52
nmol/l
2.63
109
1052
11
100
1.10
0.05
1.0
2.5
28.55
29.96
%
0.10
11
100
186
1837
1.01
0.05
2.6
3.1
7.33
7.35
ph
0.26
135
1330
319
3218
0.99
0.05
1.6
1.5
—
—
—
0
0
82
805
1.02
0.04
1.2
1.1
—
—
—
0
0
13
121
1.07
0.03
1.4
1.3
5.55
6.30
mmol/l
1.30
13
113
220
2219
0.99
0.03
1.3
1.3
—
—
—
0
0
323
3251
0.99
0.03
1.7
1.6
—
—
—
0
0
120
1185
1.01
0.03
1.4
1.4
23.79
23.48
u/l
0.04
95
984
178
1797
0.99
0.03
1.9
2.1
0.18
0.26
e6/l
0.69
166
1676
22
211
1.04
0.03
5.0
4.4
—
—
—
0
0
61
620
0.98
0.02
1.1
1.2
179.98
1930.52
pmol/l
—
9
56
315
3163
1.00
0.01
1.6
1.5
1.24
1.25
mm
0.29
219
2334
34
347
0.98
0.01
2.3
1.9
—
—
—
0
0
70
693
1.01
0.01
1.1
1.1
—
—
—
0
0
10
94
1.06
0.01
2.2
1.5
38.93
36.61
g/l
—
10
87
14
146
0.96
0.00
2.5
1.3
4551.67
25246.21
e6/l
—
9
96
17
176
0.97
0.00
1.1
1.1
—
—
—
0
0
30
306
0.98
0.00
1.0
1.1
—
—
—
0
0
17
175
0.97
0.00
1.1
1.1
15.43
9.41
u/ml
—
10
126
10
101
0.99
0.00
1.1
1.0
4.08
5.27
u/ml
—
10
101
67
669
1.00
0.00
1.1
1.1
1.75
4.06
eliau/ml
2.40
35
359
199
1985
1.00
0.00
1.3
1.3
—
—
—
0
0
9
94
0.96
0.00
9.2
15.6
1179.33
1205.30
nmol/l
—
9
89
8
88
0.91
0.00
2.0
2.8
14.55
14.72
umol/l
—
8
88
0
8
0.00
-0.00
0.0
1.6
—
495.38
—
0
8
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
61
0.98
-0.00
1.5
2.4
17.70
16.57
%
—
6
61
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
69.07
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
1.39
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
77.83
—
0
6
0
7
0.00
-0.00
0.0
2.9
—
112.29
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
69.17
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
65.33
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
2461.20
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint O15_ICP_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
O15_ICP_EXMORE 0.646 [0.5, 0.83] < 0.001
Birth year 0.997 [0.99, 1.01] 0.437

During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 13331 females with O15_ICP_EXMORE died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_ICP_EXMORE.

N-year risk Females Males
1 0.056% No data
5 0.38% No data
10 1.081% No data
15 1.972% No data
20 3.48% No data

Relationships between endpoints

↥

Index endpoint: O15_ICP_EXMORE – Intrahepatic Cholestasis of Pregnancy (ICP) , excluding more controls

GWS hits: 32

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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