No definition available.
Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8, excluding more controls
O15_ICP_WIDE_EXMORE
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleonly females |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
- Control exclude
- !(O15_DELIVERY, O15_DELIVERY_PROXY)
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
- Parent code in ICD-10
- O26
- Name in latin
- Morbositates hepatis in graviditate, intra labores et/sive in puerperio
Similar endpoints
↥List of similar endpoints to
Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8, excluding more controls
based on the number of shared cases.
Similar with more cases:
- Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8
- Pregnancy, childbirth and the puerperium
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 23532 | 23532 | - |
| Only index persons | 23124 | 23124 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.67 | 0.67 | - |
| Only index persons | 0.85 | 0.85 | - |
| Median age at first event (years) | |||
| Whole population | - | 29.44 | - |
| Only index persons | - | 29.44 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3628 | 3628 | - |
| Unadjusted period prevalence (%) | 1.29 | 1.29 | - |
| Median age at first event (years) | 29.74 | 29.74 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 3766
- Matched controls
- 37660
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A05AA02
ATC
ursodeoxycholic acid; oral
76.6
307.7
1081
197
6467A
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Liver disorders in pregnancy[HEPATOSIS GRAVIDARUM]
+∞
307.7
733
*
O26.6
ICD-10 Finland
Liver disorders in pregnancy, childbirth and the puerperium
7218.0
307.7
2475
10
63900
ICD-8 Finland
Other toxaemias of pregnancy and the puerperium, Pruritus
+∞
307.7
625
*
63998
ICD-8 Finland
Other toxaemias of pregnancy and the puerperium, Alia definitae
23.8
107.4
77
33
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.6
76.6
488
2018
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
2.3
69.9
611
2913
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.3
67.1
608
2940
O80.8
ICD-10 Finland
Other single spontaneous delivery
1.9
36.4
480
2633
O30.0
ICD-10 Finland
Twin pregnancy
2.8
32.9
165
598
MAC10
NOMESCO Finland
Antepartum dilatation of cervical canal
2.2
30.3
263
1233
63901
ICD-8 Finland
Other toxaemias of pregnancy and the puerperium, Interus gravis
+∞
28.2
27
*
W84
ICPC
Pregnancy high risk
1.9
28.1
382
2110
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
1.6
27.9
769
5178
63909
ICD-8 Finland
Other toxaemias of pregnancy and the puerperium, Necrosis acuta et subacuta hepatis
+∞
26.1
25
*
MAC01
NOMESCO Finland
Rupture of aminiotic membrane for induction of labor
2.3
25.4
196
874
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
3.0
25.1
111
376
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
1.6
24.9
776
5362
L29.9
ICD-10 Finland
Pruritus, unspecified
2.5
23.2
148
607
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
1.4
23.1
1374
10782
5742A
ICD-9 Finland
Cholelithiasis, Calculus of gallbladder without mention of cholecystitis[CHOLECYSTOLITHIASIS SINE CHOLECYSTITIDE,SINE OBSTR]
3.4
22.5
82
247
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
3.1
22.3
95
315
MAC96
NOMESCO Finland
Other induction or advancement of labour
2.0
20.2
217
1103
O60
ICD-10 Finland
Preterm labour and delivery
2.0
18.2
213
1117
S02
ICPC
Pruritus
2.1
16.9
160
776
O98.4
ICD-10 Finland
Viral hepatitis complicating pregnancy, childbirth and the puerperium
7.0
15.3
23
33
K76.9
ICD-10 Finland
Liver disease, unspecified
3.1
14.8
61
199
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
1.4
14.7
688
5103
XMA22
NOMESCO Finland
General examination of pregnant woman
1.5
14.3
451
3096
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
1.5
14.2
448
3075
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
1.7
14.0
262
1587
6663
FHL
Cholecystectomy and cholangiography
3.4
13.7
49
147
6467X
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Liver disorders in pregnancy[HEPATOPATHIA ALIA GRAVIDARUM]
+∞
13.5
13
*
K83.0
ICD-10 Finland
Cholangitis
3.7
13.0
41
113
MAC40
NOMESCO Finland
Pharmacological induction or advancement of labor
1.8
12.8
185
1040
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
3.1
12.5
50
161
A10BX01
ATC
guar gum; oral
2.5
12.4
73
290
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.3
12.2
1529
13076
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
5.2
12.0
24
46
O84.0
ICD-10 Finland
Multiple delivery, all spontaneous
2.9
11.9
55
192
MAA00
NOMESCO Finland
Amniocentesis
1.8
11.7
165
920
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
1.4
11.7
702
5407
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.5
11.6
410
2875
ZXE00
NOMESCO Finland
One hour or less
1.3
11.5
1403
11927
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
1.8
11.0
168
961
B18.2
ICD-10 Finland
Chronic viral hepatitis C
3.1
11.0
44
142
6510B
ICD-9 Finland
Multiple gestation, Twin pregnancy[GEMINI, SYNNYTYKSEN AIKANA]
3.1
10.9
45
148
57409
ICD-8 Finland
Cholelithiasis, Unspecified
3.6
10.6
34
95
63902, ,
ICD-8 Finland
+∞
10.4
10
*
V230A
ICD-9 Finland
Supervision of high-risk pregnancy, Pregnancy with history of infertility
2.5
10.3
61
243
O36.6
ICD-10 Finland
Maternal care for excessive fetal growth
1.6
10.3
274
1810
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
3.8
10.3
31
83
O48
ICD-10 Finland
Prolonged pregnancy
0.5
10.2
100
1907
K80.1
ICD-10 Finland
Calculus of gallbladder with other cholecystitis
2.3
10.0
73
321
8811
FHL
Cesarean section
1.5
10.0
279
1864
Z2221
NOMESCO Finland
Medical doctor
1.3
9.7
962
7937
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
1.3
9.6
1164
9841
ZXD10
NOMESCO Finland
Scheduled procedure
1.3
9.5
1158
9786
G03DA04
ATC
progesterone; systemic, rectal, vaginal
1.7
9.4
160
945
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.3
9.0
703
5611
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
1.5
8.8
324
2289
O84.2
ICD-10 Finland
Multiple delivery, all by caesarean section
2.8
8.7
42
151
O26.0
ICD-10 Finland
Excessive weight gain in pregnancy
4.2
8.4
22
53
Z35.4
ICD-10 Finland
Supervision of pregnancy with grand multiparity
2.3
8.3
61
270
Z87.5
ICD-10 Finland
Personal history of complications of pregnancy, childbirth and the puerperium
2.0
8.3
80
395
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
2.9
8.1
36
124
W29
ICPC
Pregnancy symptom/complaint other
1.5
8.0
220
1467
O14.9
ICD-10 Finland
Pre-eclampsia, unspecified
1.8
8.0
107
591
K30
ICD-10 Finland
Functional dyspepsia
1.4
7.9
426
3216
6510A
ICD-9 Finland
Multiple gestation, Twin pregnancy[GEMINI, RASKAUDEN AIKANA]
3.1
7.7
30
96
L04AX01
ATC
azathioprine; systemic
1.7
7.6
130
770
K80.5
ICD-10 Finland
Calculus of bile duct without cholangitis or cholecystitis
1.9
7.6
87
456
Z35
ICD-10 Finland
Supervision of high-risk pregnancy
2.0
7.6
81
415
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
1.3
7.5
748
6145
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
2.8
7.5
35
124
1413
FHL
Laparoscopy and other therapeutic procedure
1.9
7.5
90
480
L29.8
ICD-10 Finland
Other pruritus
2.3
7.4
53
232
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
1.8
7.4
107
605
O30.00
ICD-10 Finland
Twin pregnancy with separate amniotic and chorionic sacs
2.5
7.4
46
189
6480A
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Diabetes mellitus
2.9
7.4
34
120
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
2.3
7.3
55
246
A10AC01
ATC
insulin (human); parenteral
1.5
7.3
195
1292
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
1.4
7.2
266
1881
B01AB04
ATC
dalteparin; parenteral
1.6
6.9
150
948
A02BC01
ATC
omeprazole; systemic
1.2
6.6
855
7232
6662
FHL
Cholecystectomy
2.7
6.6
34
128
O26.9
ICD-10 Finland
Pregnancy-related condition, unspecified
2.2
6.5
49
220
O14.0
ICD-10 Finland
Mild to moderate pre-eclampsia
1.7
6.5
115
691
MA2XE
NOMESCO Finland
Other obstetric ultrasound examination
1.3
6.5
462
3636
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
1.6
6.4
142
902
57401
ICD-8 Finland
Cholelithiasis, Cum cholecystitide chronica
3.4
6.4
22
65
G03DB01
ATC
dydrogesterone; oral
1.3
6.4
642
5275
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.2
6.4
763
6395
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
3.7
6.4
19
51
5740A
ICD-9 Finland
Cholelithiasis, Calculus of gallbladder with acute cholecystitis[CHOLECYSTOLITHIASIS CUM CHOLECYSTITIDE AC,SINE OBST]
4.1
6.3
17
42
WX321
NOMESCO Finland
Acute spinal anesthesia for delivery
1.4
6.3
289
2125
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
6.5
6.3
15
23
O82.0
ICD-10 Finland
Delivery by elective caesarean section
1.4
6.3
316
2360
K50.9
ICD-10 Finland
Crohn disease, unspecified
2.1
6.2
52
244
MBA00
NOMESCO Finland
Vacuum aspiration from uterus after delivery or abortion
1.6
6.1
123
763
A02BC05
ATC
esomeprazole; systemic
1.2
6.1
1278
11313
O61.0
ICD-10 Finland
Failed medical induction of labour
1.9
6.1
77
419
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
968
1470
8.52
307.65
6.3
1.5
10.22
4.10
umol/l
24.29
867
1024
358
696
5.58
176.71
1.3
1.3
142.41
157.74
au/ml
1.52
138
166
372
765
5.29
172.38
1.3
1.3
14.08
16.35
u/ml
—
5
18
361
724
5.41
172.07
1.2
1.2
195.03
263.46
u/ml
6.83
285
465
162
234
7.19
106.95
1.2
1.2
83.33
87.36
—
6
11
625
3734
1.81
36.29
2.6
2.4
6.22
6.37
umol/l
0.08
550
3217
2030
16416
1.51
33.11
5.7
5.8
9.89
9.62
umol/l
0.43
1931
15607
230
1023
2.33
30.06
1.4
1.2
83.48
168.11
titre
0.78
23
95
1516
11710
1.49
29.78
3.7
3.0
33.50
28.72
u/l
4.08
1442
11167
356
2074
1.79
21.90
1.8
1.9
1.45
1.35
g/l
0.34
328
1932
2738
24403
1.45
21.58
8.5
7.5
80.08
73.05
u/l
13.11
2617
23272
431
2692
1.68
20.63
2.7
2.8
10.50
10.40
g/l
0.27
395
2500
3665
35267
2.46
18.64
13.5
10.3
31.47
23.61
u/l
44.51
3614
34529
974
7680
1.36
14.39
4.2
3.3
98.78
97.89
%
0.63
946
7463
2705
24776
1.33
13.06
3.6
3.0
39.59
34.19
u/l
3.72
2582
23805
370
2485
1.54
12.93
2.4
2.2
0.22
0.22
g/l
0.10
346
2348
1068
8668
1.32
12.71
1.5
1.4
2.10
2.14
g/l
0.43
696
5647
1771
15383
1.29
12.61
10.3
9.5
0.00
0.00
e9/l
1.45
1443
12714
398
2756
1.50
12.02
3.3
4.5
241.22
233.24
u/l
0.16
381
2625
1257
10502
1.30
11.93
2.6
2.5
62.77
57.21
u/l
0.65
1183
9825
1832
16121
1.27
11.21
6.8
5.8
56.25
56.25
%
0.00
1774
15452
1857
16389
1.26
11.01
6.9
5.9
29.76
29.75
%
0.02
1781
15585
1367
11646
1.27
10.85
6.6
7.6
1.06
1.08
inr
2.19
1136
9662
92
440
2.12
10.23
1.1
1.1
1.39
1.46
g/l
0.79
81
401
1497
12986
1.25
9.94
5.0
4.4
36.75
36.91
g/l
0.56
1412
12315
418
3049
1.42
9.57
2.6
2.4
35.81
35.08
u/l
0.09
373
2577
55
227
2.44
8.70
1.3
1.2
254.38
176.25
titre
0.30
16
48
62
276
2.27
8.30
1.1
1.1
310.16
293.95
mg/l
0.57
51
253
116
654
1.80
8.07
2.0
1.5
9.03
5.12
iu/ml
—
6
13
156
962
1.65
7.87
2.1
1.9
1.15
1.35
g/l
1.99
136
836
1987
18038
1.22
7.87
7.1
5.9
0.18
0.18
e9/l
0.13
1798
16155
1962
17816
1.21
7.65
7.0
5.9
1.94
1.96
e9/l
0.39
1781
16101
618
4987
1.29
7.16
2.2
2.3
14.43
14.53
umol/l
0.13
573
4676
1206
10499
1.22
7.10
1.4
1.3
1.02
1.50
u/ml
2.01
355
3212
502
3980
1.30
6.64
2.2
2.3
23.64
23.70
%
0.03
467
3703
215
1491
1.47
6.49
1.4
1.4
—
—
—
0
0
928
7932
1.23
6.44
1.4
1.3
8.65
8.99
u/ml
0.07
364
3441
54
255
2.13
6.35
1.0
1.1
—
—
—
0
0
978
8416
1.22
6.33
3.1
2.8
0.19
0.31
e6/l
2.02
684
6016
2284
21243
1.19
6.22
3.7
3.4
65.78
71.44
ug/l
1.99
2189
20265
564
4580
1.27
6.17
2.7
2.6
4.92
4.84
e6/l
0.03
250
2124
554
4499
1.27
6.05
2.2
2.2
2.47
2.47
g/l
0.07
508
4153
2692
25450
1.20
5.96
4.9
4.2
10.26
9.72
mm/h
1.65
2573
24264
990
8576
1.21
5.93
1.4
1.4
25.28
26.44
iu/ml
0.11
290
2625
1408
12619
1.18
5.75
2.0
1.9
102.45
99.80
pmol/l
1.16
736
6739
1771
16182
1.18
5.74
2.7
2.4
76.98
76.04
nmol/l
0.79
1655
15221
236
1721
1.40
5.46
1.9
2.0
0.03
0.02
estimate
0.15
89
679
896
7745
1.21
5.43
1.6
1.6
21.30
20.92
nmol/l
0.35
779
6792
697
5885
1.23
5.35
3.1
2.5
96.74
104.91
ug/g
0.35
558
4655
3392
32952
1.30
5.29
6.2
5.9
1.68
1.72
mu/l
0.95
3250
31569
1108
9788
1.19
5.25
3.2
2.9
31.52
62.55
e6/l
1.21
795
7301
122
787
1.57
5.24
4.8
3.6
704.15
393.74
u/ml
0.27
108
676
2926
27993
1.20
5.18
4.1
3.8
—
—
—
0
0
994
8714
1.19
5.12
2.5
2.2
2.43
2.57
mg/l
1.66
877
7650
56
292
1.93
5.10
1.3
1.2
47.69
60.20
u/l
1.62
51
265
2081
19384
1.16
5.00
9.1
8.4
3.83
3.91
e9/l
1.04
1834
17025
155
1074
1.46
4.78
2.3
1.5
6.62
11.74
iu/ml
—
6
29
947
8349
1.18
4.49
1.9
1.8
1.06
0.91
mg/l
1.04
716
6368
36
168
2.15
4.46
3.2
3.2
8.55
8.72
mg/l
0.05
29
127
898
7889
1.18
4.43
2.3
2.1
295.81
296.55
umol/l
0.09
808
7183
3104
29974
1.20
4.40
5.1
4.8
37.00
37.14
mmol/mol
0.49
2966
28662
47
248
1.91
4.20
1.3
1.5
—
—
—
0
0
3378
32933
1.25
4.15
12.8
11.8
139.69
139.65
mmol/l
0.51
3324
32311
3103
30000
1.20
4.15
16.4
14.3
13.37
13.35
%
0.33
3073
29650
1357
12371
1.15
4.09
3.9
3.5
66.72
74.09
e6/l
0.20
882
8059
35
169
2.08
4.01
1.8
1.5
2.92
5.68
u/l
1.60
25
139
3266
31750
1.22
3.99
12.0
10.6
90.67
90.37
ml/min/173m2
0.41
3017
28919
1547
14262
1.14
3.92
6.0
5.8
1.22
1.22
mmol/l
1.09
1339
12377
469
3929
1.22
3.86
2.4
2.0
28.79
28.76
s
0.04
451
3802
3067
29666
1.18
3.86
5.3
5.1
14.40
14.35
pmol/l
0.63
2901
28229
1505
13878
1.14
3.75
1.8
1.8
1.21
1.31
mmol/l
5.71
1297
12080
159
1163
1.38
3.71
2.6
2.2
3.98
3.66
g/l
1.85
146
1099
3377
32992
1.23
3.61
13.0
11.9
3.89
3.90
mmol/l
1.52
3319
32290
239
3030
0.77
3.59
5.1
4.9
—
—
—
0
0
1362
12506
1.14
3.58
5.7
5.2
1.22
1.22
mmol/l
1.11
1292
11677
588
5075
1.19
3.52
2.7
2.5
2.15
1.03
e6/l
0.60
271
2629
361
2976
1.24
3.48
2.4
2.4
16.55
19.56
au/ml
0.55
35
412
336
2768
1.23
3.27
1.3
1.3
17.66
44.94
au/ml
3.52
11
163
98
677
1.46
3.19
2.2
2.3
10.07
10.23
g/l
0.18
93
629
218
1713
1.29
3.17
2.0
2.7
65.16
72.15
e9/l
2.80
149
1230
365
3068
1.21
2.94
1.4
1.3
183.42
143.71
u/ml
0.27
345
2867
49
295
1.67
2.93
2.6
2.5
22.76
25.43
mg/l
0.20
34
199
91
632
1.45
2.91
1.5
1.4
—
—
—
0
0
2552
24532
1.12
2.87
4.8
4.3
570.67
1955.31
e6/l
1.33
27
268
110
796
1.39
2.82
2.7
2.7
1.79
1.59
index
0.08
58
402
1204
11105
1.12
2.80
1.8
1.8
—
—
—
0
0
89
622
1.44
2.77
2.2
2.2
0.00
0.02
g/l
1.10
83
571
53
331
1.61
2.77
1.1
1.2
—
1.15
—
0
7
1982
18808
1.11
2.75
4.6
4.1
6.17
6.22
mmol/l
0.47
1808
16943
506
4405
1.17
2.75
3.2
3.2
0.83
0.82
mmol/l
0.84
482
4183
100
716
1.41
2.73
2.7
2.4
0.58
0.59
g/l
0.00
92
635
7
14
5.01
2.72
1.0
1.0
—
—
—
0
0
170
1325
1.30
2.68
1.5
1.6
0.23
0.28
mg/l
0.53
59
535
228
1846
1.25
2.64
2.3
2.0
7.83
6.73
iu/ml
0.22
54
448
81
562
1.45
2.64
3.9
5.2
123.71
345.41
iu/ml
—
7
66
1249
11586
1.12
2.60
3.3
2.9
0.02
0.10
estimate
0.58
441
3660
84
589
1.44
2.59
2.1
2.2
0.00
0.00
g/l
-0.00
76
526
86
606
1.43
2.59
1.8
1.6
16394.58
6637.80
e6/l
0.88
57
435
96
691
1.40
2.57
2.5
2.7
28.50
31.72
iu/ml
—
5
35
316
2662
1.20
2.52
2.5
2.7
—
—
—
0
0
57
374
1.53
2.45
1.1
1.1
7.48
9.07
iu/ml
0.24
17
106
369
3162
1.19
2.44
3.0
3.6
4.57
4.56
pmol/l
0.06
339
2889
751
6785
1.13
2.42
2.7
2.4
8.70
8.25
e6/l
0.13
669
6112
219
1786
1.24
2.41
2.2
2.7
66.94
67.15
g/l
0.18
203
1666
148
1152
1.30
2.39
1.2
1.2
4.41
4.71
0.16
31
185
412
3572
1.17
2.37
2.0
2.2
377.18
372.40
nmol/l
0.20
390
3340
3565
35194
1.24
2.36
15.4
13.9
66.14
66.07
umol/l
0.09
3544
34855
52
340
1.54
2.29
1.2
1.1
16.47
16.08
u/ml
0.04
27
162
482
4245
1.16
2.27
1.6
1.6
1.35
1.33
%
0.27
424
3789
217
1782
1.23
2.26
7.5
6.8
7.58
7.23
mmol/l
0.39
208
1729
110
829
1.34
2.25
1.1
1.1
12.89
16.54
au/ml
0.33
35
236
179
1439
1.26
2.25
2.1
2.1
40.05
39.49
u/l
0.15
166
1338
41
255
1.61
2.24
1.5
1.6
277.91
278.10
mosm/kgh2o
0.02
35
210
110
834
1.33
2.18
2.1
2.4
7.16
7.21
g/l
0.14
105
790
110
834
1.33
2.18
2.1
2.4
4.24
4.35
g/l
0.91
105
789
928
8543
1.11
2.17
2.0
2.0
133.80
138.08
u/l
0.12
893
8168
36
221
1.64
2.08
1.3
1.2
—
—
—
0
0
109
833
1.32
2.06
2.1
2.4
3.60
3.68
g/l
0.34
104
789
217
2599
0.82
2.05
1.4
1.5
—
—
—
0
0
10
38
2.64
2.00
1.0
1.2
—
—
—
0
0
180
1471
1.23
1.99
1.9
2.2
3.00
7.48
iu/l
0.69
78
662
56
385
1.46
1.99
1.4
1.3
1183.33
1029.23
titre
0.41
12
65
3208
31466
1.13
1.98
4.2
4.1
5.58
5.59
mmol/l
0.38
3028
29821
105
804
1.31
1.97
2.1
2.4
2.71
2.79
g/l
0.37
100
760
433
3826
1.15
1.97
1.7
1.6
1125.47
1188.23
nmol/l
0.83
351
3060
223
1872
1.20
1.91
1.3
1.3
0.29
1.05
u/ml
2.25
16
140
638
5800
1.12
1.86
2.7
2.6
611.28
570.66
ng/l
0.10
517
4744
1216
11448
1.09
1.76
3.1
2.8
0.31
0.04
0.83
16
186
162
1329
1.23
1.76
1.5
1.5
—
—
—
0
0
62
446
1.40
1.76
1.2
1.2
—
—
—
0
0
62
446
1.40
1.76
1.2
1.2
—
—
—
0
0
170
1404
1.22
1.74
2.3
2.6
67.71
98.65
ng/l
2.43
150
1274
544
4937
1.12
1.65
3.3
3.0
261.17
275.95
ng/l
0.05
296
2687
101
794
1.28
1.61
1.2
1.3
—
—
—
0
0
57
412
1.39
1.60
2.3
2.6
14.22
102.11
ug/min
3.59
39
253
15
77
1.95
1.59
2.5
2.5
0.63
0.61
mmol/l
0.40
15
77
153
1264
1.22
1.59
2.5
2.1
0.23
0.23
g/l
0.24
148
1205
59
430
1.38
1.58
1.7
1.6
—
—
—
0
0
27
167
1.62
1.58
1.0
1.1
—
—
—
0
0
2088
20165
1.08
1.57
3.9
3.6
2.50
3.60
estimate
0.16
520
4426
154
1275
1.22
1.57
1.5
1.6
0.05
16.86
iu/ml
0.51
21
200
61
449
1.36
1.55
1.4
1.5
33.69
24.29
ng/l
0.49
61
449
141
1160
1.22
1.53
1.3
1.3
63.51
38.47
u/ml
—
10
113
51
365
1.40
1.53
1.4
1.2
—
—
—
0
0
457
4128
1.12
1.51
2.8
2.3
6248.19
7411.49
u/l
0.38
213
1930
155
1293
1.21
1.48
1.3
1.3
6.05
5.03
u/ml
0.10
12
120
38
259
1.47
1.48
2.1
1.3
—
—
—
0
0
24
147
1.64
1.47
1.1
1.1
—
—
—
0
0
384
3440
1.13
1.47
4.1
4.0
33.59
32.92
%
0.63
281
2548
5
16
3.13
1.44
1.8
1.4
—
—
—
0
0
154
1290
1.20
1.42
1.3
1.4
6.28
7.27
u/ml
0.11
16
201
15
81
1.86
1.40
1.1
1.1
—
—
—
0
0
980
9227
1.08
1.39
3.9
3.2
7.39
7.28
mmol/l
0.31
846
8044
52
382
1.37
1.36
1.4
1.2
—
—
—
0
0
52
382
1.37
1.36
1.4
1.2
—
—
—
0
0
123
1013
1.22
1.35
1.7
1.5
—
—
—
0
0
50
366
1.37
1.34
1.3
1.2
—
—
—
0
0
6
24
2.50
1.30
1.0
1.2
—
—
—
0
0
80
631
1.27
1.30
1.2
1.1
1.83
3.20
0.77
23
121
844
7923
1.08
1.29
4.4
3.9
8.49
8.80
mg/mmol
0.08
496
4661
59
447
1.33
1.29
2.0
1.2
531.43
509.74
titre
—
7
39
144
1212
1.20
1.28
11.7
9.2
16.08
16.09
%
0.02
137
1160
187
1611
1.17
1.27
3.0
2.8
1.02
1.02
ratio
0.79
162
1395
962
9089
1.08
1.25
2.2
1.9
—
—
—
0
0
59
450
1.32
1.24
2.0
1.2
—
215.00
—
0
8
449
4103
1.11
1.24
1.3
1.3
172.45
148.38
u/ml
0.56
179
1692
1124
10684
1.07
1.24
3.1
3.2
2.35
2.35
mmol/l
0.03
1032
9929
2093
20317
1.07
1.23
4.0
3.7
0.00
0.25
estimate
0.56
512
4341
23
147
1.57
1.22
1.3
1.6
—
—
—
0
0
58
443
1.31
1.21
1.4
1.2
—
—
—
0
0
27
180
1.50
1.20
1.1
1.1
96.27
98.53
%
0.23
11
73
56
426
1.32
1.20
1.3
1.5
—
2537.14
—
0
7
1076
10221
1.07
1.20
2.8
2.7
23.91
35.44
ng/l
0.55
476
4778
166
1425
1.17
1.20
1.3
1.3
84.22
30.97
u/ml
—
6
95
355
3211
1.12
1.19
5.2
4.8
1.04
1.04
mmol/l
0.19
335
2980
665
6207
1.09
1.17
1.7
1.6
13536812.35
38784191.58
pmol/l
0.99
591
5443
52
394
1.32
1.16
1.4
1.2
—
—
—
0
0
106
878
1.21
1.14
2.1
2.2
10.36
10.64
mg/l
0.16
99
836
7
30
2.34
1.12
1.1
1.1
—
—
—
0
0
11
58
1.90
1.12
1.0
1.1
—
—
—
0
0
255
2272
1.13
1.11
3.3
3.3
1.23
1.23
mmol/l
0.71
227
1959
39
287
1.36
1.06
1.3
1.3
—
—
—
0
0
6
123
0.49
1.05
4.2
2.7
—
—
—
0
0
844
8903
0.93
1.03
3.7
3.6
1.02
1.36
kg/l
0.80
579
5869
7
34
2.06
1.02
1.1
1.1
—
—
—
0
0
2052
19978
1.06
1.02
3.9
3.6
0.00
0.00
estimate
2.09
516
4384
1135
10857
1.06
1.02
3.7
3.7
0.01
0.00
estimate
0.19
508
4231
23
155
1.49
1.01
1.3
1.2
—
1065.00
—
0
6
43
325
1.33
1.00
1.2
1.2
0.61
0.69
ratio
0.71
18
196
26
180
1.45
1.00
1.1
1.1
—
—
—
0
0
230
2053
1.13
1.00
3.4
3.1
71.82
73.21
ng/l
0.11
207
1826
16
99
1.62
0.99
1.4
5.8
10792.36
62.53
mg/l
0.47
11
70
18
115
1.57
0.99
1.1
1.1
—
—
—
0
0
122
1041
1.18
0.99
1.3
1.3
1.21
4.18
u/ml
—
7
61
131
1519
0.86
0.97
1.3
1.2
12.35
12.07
u/l
0.08
109
1288
39
292
1.34
0.97
1.7
1.7
54.40
49.72
%
0.27
25
172
140
1211
1.16
0.96
1.5
1.5
—
—
—
0
0
101
850
1.19
0.96
1.6
1.5
6.51
6.65
mmol/l
0.26
87
777
13
211
0.61
0.96
2.0
2.4
—
—
—
0
0
2958
29993
0.94
0.93
17.1
15.0
331.36
331.90
g/l
3.07
2940
29855
15
93
1.62
0.93
1.1
1.1
—
—
—
0
0
390
3598
1.09
0.93
1.8
1.6
—
—
—
0
0
25
175
1.43
0.92
1.2
1.3
147.36
142.81
mmol/24h
0.12
25
175
31
226
1.37
0.92
1.2
1.1
—
—
—
0
0
37
278
1.33
0.91
1.2
1.2
69.49
71.00
ug/l
0.06
37
278
84
699
1.21
0.91
1.4
1.2
2.11
4.21
u/ml
3.01
37
287
457
4249
1.09
0.91
1.8
1.8
—
—
—
0
0
14
86
1.63
0.90
6.1
4.8
—
—
—
0
0
25
176
1.42
0.90
1.2
1.1
101.36
102.32
%
0.07
11
72
356
3276
1.10
0.90
2.0
1.8
—
—
—
0
0
34
253
1.35
0.90
1.6
2.5
31.74
32.00
pg
0.13
34
253
88
738
1.20
0.89
1.3
1.2
1.24
3.34
u/ml
2.29
33
279
8
42
1.91
0.88
2.1
1.8
—
—
—
0
0
9
153
0.59
0.88
1.9
1.4
—
—
—
0
0
38
290
1.31
0.86
2.3
2.7
—
—
—
0
0
3444
34160
1.10
0.85
13.9
12.1
17.98
19.05
mg/l
1.31
2828
27856
8
141
0.57
0.82
2.0
1.5
—
—
—
0
0
21
295
0.71
0.81
1.4
1.5
—
—
—
0
0
114
989
1.16
0.80
1.1
1.1
0.93
1.73
u/ml
0.95
55
479
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
34
259
1.32
0.79
2.0
1.8
129.86
124.57
%
0.19
34
246
126
1437
0.87
0.79
1.4
1.4
3.19
3.90
ug/l
1.06
117
1326
106
915
1.16
0.79
1.4
1.4
315.80
306.88
ug/g
0.17
55
471
0
26
0.00
0.78
0.0
6.2
—
10.76
—
0
26
18
258
0.70
0.78
1.4
1.1
9.44
9.28
mm/h
0.03
18
258
33
251
1.32
0.78
1.4
1.2
—
—
—
0
0
12
74
1.62
0.78
1.3
1.1
—
—
—
0
0
3322
32924
1.08
0.76
4.5
4.3
4.77
4.84
mmol/l
4.25
3196
31633
781
7455
1.06
0.76
1.6
1.6
991.12
1004.36
mu/l
0.15
650
6359
138
1219
1.14
0.76
1.2
1.1
1.80
2.10
u/ml
0.17
77
630
3311
32815
1.07
0.75
4.4
4.2
1.56
1.56
mmol/l
0.23
3177
31405
213
2344
0.90
0.75
1.5
1.4
—
—
—
0
0
875
8385
1.06
0.74
2.2
2.2
—
—
—
0
0
12
75
1.60
0.74
1.1
1.1
—
—
—
0
0
3344
33158
1.08
0.73
4.8
4.7
2.83
2.87
mmol/l
2.83
3203
31730
5
25
2.00
0.72
1.2
1.0
8.16
8.19
mmol/l
—
5
25
99
858
1.16
0.72
1.1
1.1
1.69
4.65
u/ml
2.69
45
381
32
246
1.30
0.72
2.5
3.1
10.20
14.49
index
3.14
15
135
7
40
1.75
0.71
1.1
1.1
—
—
—
0
0
158
1417
1.12
0.70
3.4
2.8
5.09
5.11
kpa
0.17
149
1367
195
1770
1.11
0.69
1.9
1.6
3.05
4.02
mg/l
1.27
152
1267
50
409
1.23
0.69
1.1
1.1
187.38
204.28
mg/l
0.76
44
367
186
1686
1.11
0.68
1.6
1.6
9.85
11.70
u/ml
0.32
49
450
216
1974
1.10
0.68
1.6
1.6
—
—
—
0
0
29
222
1.31
0.68
1.9
1.6
46.66
41.71
%
0.26
20
127
114
1291
0.88
0.67
5.8
6.9
24.72
24.35
mmol/l
0.60
105
1234
192
1745
1.11
0.67
1.1
1.1
0.58
0.60
ratio
0.29
29
184
460
4338
1.07
0.67
1.3
1.3
26.47
26.31
iu/l
0.04
405
3787
15
102
1.47
0.67
2.3
2.3
—
—
—
0
0
273
2524
1.09
0.67
1.6
1.6
367.38
279.56
mu/l
0.36
243
2240
82
706
1.17
0.66
2.6
2.0
168.28
255.40
ug/l
0.71
70
639
5
28
1.79
0.66
1.4
1.1
—
—
—
0
0
11
70
1.57
0.65
1.1
1.1
—
—
—
0
0
128
1140
1.13
0.65
2.2
2.0
—
—
—
0
0
40
322
1.24
0.65
1.2
1.2
—
—
—
0
0
85
736
1.16
0.64
1.4
1.6
—
—
—
0
0
20
146
1.37
0.63
1.1
1.0
320.60
322.32
ng/l
0.01
15
109
51
423
1.21
0.63
1.3
1.4
—
—
—
0
0
10
153
0.65
0.62
1.8
1.4
—
—
—
0
0
25
190
1.32
0.62
1.2
1.2
—
—
—
0
0
581
5536
1.06
0.62
2.5
2.5
2.43
2.42
mmol/l
0.34
512
4956
20
147
1.36
0.61
1.1
1.0
691.07
771.22
ng/l
0.32
14
105
14
96
1.46
0.61
1.1
1.2
97.79
96.14
%
0.09
14
96
42
343
1.23
0.61
1.2
1.2
0.46
1.19
u/ml
0.70
21
171
40
325
1.23
0.61
1.2
1.2
—
—
—
0
0
116
1033
1.13
0.60
2.1
1.9
—
—
—
0
0
31
387
0.80
0.57
1.9
1.5
—
—
—
0
0
20
149
1.34
0.57
1.1
1.0
40.67
42.91
ng/l
0.09
15
111
411
3887
1.06
0.57
1.5
1.5
—
—
—
0
0
21
158
1.33
0.57
1.2
1.2
—
—
—
0
0
39
319
1.22
0.57
1.9
1.9
18.45
23.92
mg/l
0.36
13
130
3120
30925
1.05
0.56
3.8
3.6
1.11
1.18
mmol/l
10.11
2991
29457
51
430
1.19
0.55
1.3
1.4
—
—
—
0
0
50
421
1.19
0.55
1.3
1.4
—
—
—
0
0
45
536
0.84
0.54
1.6
1.4
—
—
—
0
0
6
38
1.58
0.54
2.2
2.2
31.50
20.77
mg/l
—
6
38
6
38
1.58
0.54
1.2
1.1
—
—
—
0
0
6
38
1.58
0.54
1.3
1.3
—
—
—
0
0
50
422
1.19
0.54
1.1
1.2
41.61
35.90
mg/l
0.26
40
357
22
169
1.30
0.53
1.3
1.6
0.77
3.00
u/field
2.13
13
119
15
108
1.39
0.53
1.1
1.1
15.47
35.66
iu/ml
1.66
15
108
56
652
0.86
0.52
1.4
1.5
55.42
34.98
nmol/l
0.48
48
596
80
907
0.88
0.52
1.2
1.2
—
—
—
0
0
786
7588
1.05
0.52
2.1
2.1
—
—
—
0
0
271
2538
1.07
0.52
1.1
1.1
—
—
—
0
0
6
40
1.50
0.51
1.0
1.0
—
—
—
0
0
53
618
0.86
0.51
1.1
1.2
2.13
19134.89
iu/ml
—
8
140
19
144
1.32
0.50
1.5
1.7
—
—
—
0
0
19
144
1.32
0.50
1.5
1.7
—
—
—
0
0
19
144
1.32
0.50
1.5
1.7
—
—
—
0
0
19
144
1.32
0.50
1.5
1.7
—
—
—
0
0
23
291
0.79
0.49
4.5
4.5
6.84
6.67
mmol/l
0.07
16
242
27
335
0.80
0.49
1.1
1.1
1651.78
1489.01
miu/ml
0.41
27
335
10
67
1.49
0.49
1.1
1.3
—
—
—
0
0
47
399
1.18
0.49
1.3
1.4
—
—
—
0
0
78
690
1.13
0.48
1.2
1.2
—
—
—
0
0
101
908
1.12
0.48
1.1
1.1
0.82
4.65
u/ml
4.62
48
446
413
3933
1.06
0.48
1.6
1.5
1.22
1.16
ratio
0.68
253
2403
435
4154
1.05
0.46
1.6
1.5
67.12
62.07
ug/l
1.24
347
3521
67
589
1.14
0.46
2.8
2.4
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
58
505
1.15
0.45
3.4
3.8
0.39
0.37
iu/ml
0.23
27
274
115
1046
1.10
0.45
1.1
1.1
3.35
5.35
u/ml
0.98
55
551
56
487
1.15
0.45
3.6
3.7
2.23
2.13
ratio
0.04
30
271
47
403
1.17
0.45
1.3
1.4
—
—
—
0
0
115
1048
1.10
0.44
1.8
1.6
7.64
7.57
mmol/l
0.14
108
1012
47
404
1.17
0.44
1.3
1.4
—
—
—
0
0
59
672
0.88
0.44
1.5
1.6
—
—
—
0
0
413
3947
1.05
0.43
1.6
1.5
1.16
1.20
ratio
0.34
256
2434
413
3947
1.05
0.43
1.6
1.5
0.93
0.95
ratio
0.57
254
2418
11
78
1.41
0.43
2.2
3.1
0.86
1.42
%
0.75
11
78
5
31
1.61
0.43
1.6
1.9
—
—
—
0
0
5
31
1.61
0.43
2.2
2.3
—
—
—
0
0
518
4985
1.05
0.41
1.5
1.5
—
—
—
0
0
74
661
1.12
0.41
1.5
1.3
—
—
—
0
0
38
323
1.18
0.41
1.2
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
0.07
—
0
5
0
15
0.00
0.41
0.0
1.0
—
0.11
—
0
5
45
389
1.16
0.40
1.1
1.1
—
—
—
0
0
5
34
1.47
0.40
1.2
2.1
0.60
0.91
u/field
—
5
34
128
1180
1.09
0.40
3.4
2.7
1.80
1.56
mmol/l
0.34
82
856
5
35
1.43
0.39
2.0
1.7
5.80
5.71
ug/l
—
5
35
5
35
1.43
0.39
1.2
1.1
51.20
93.26
titre
—
5
35
57
503
1.14
0.39
2.2
2.4
0.89
0.87
nmol/l
0.08
47
439
102
932
1.10
0.39
3.6
5.1
1.76
1.67
%
0.23
95
875
16
124
1.29
0.38
1.1
5.5
—
59.31
—
0
13
20
160
1.25
0.38
1.3
1.5
120.80
125.00
nmol/l
0.21
20
160
9
66
1.36
0.38
1.2
1.5
1.21
1.18
mmol/l
—
9
66
36
420
0.86
0.38
1.5
1.7
—
—
—
0
0
108
991
1.09
0.38
1.1
1.1
0.98
1.14
u/ml
0.12
45
403
26
215
1.21
0.38
1.3
1.4
71.19
67.79
umol/l
0.47
26
215
99
905
1.10
0.37
1.1
1.2
3.64
3.60
mmol/l
0.17
94
857
10
136
0.73
0.37
3.5
2.1
1.77
1.11
ug/l
—
10
131
16
125
1.28
0.37
1.0
1.1
—
—
—
0
0
141
1514
0.93
0.36
2.1
2.0
11.21
5.01
ug/l
1.14
123
1346
139
1295
1.08
0.35
1.1
1.1
7.40
6.85
eliau/ml
0.03
20
202
63
565
1.12
0.35
3.6
4.0
33.78
44.13
mg/l
0.64
55
491
91
833
1.09
0.34
1.1
1.1
—
0.42
—
0
6
75
680
1.11
0.34
1.1
1.1
—
—
—
0
0
6
87
0.69
0.33
1.2
1.3
—
—
—
0
0
307
2941
1.05
0.32
1.5
1.6
—
—
—
0
0
27
317
0.85
0.32
1.1
1.1
—
—
—
0
0
11
83
1.33
0.32
1.1
1.1
—
—
—
0
0
258
2463
1.05
0.31
4.7
4.1
56.52
33.79
ug/l
0.24
191
1846
83
763
1.09
0.30
1.1
1.1
0.05
0.28
u/ml
0.91
25
224
38
431
0.88
0.30
1.3
1.6
—
—
—
0
0
12
93
1.29
0.30
1.4
1.3
10.42
12.82
u/l
0.38
12
87
299
2871
1.05
0.29
3.2
2.9
34.11
45.41
u/ml
0.61
289
2782
14
112
1.25
0.28
1.1
1.1
—
—
—
0
0
19
158
1.20
0.28
1.3
1.5
12.45
13.92
pmol/l
0.81
19
127
62
565
1.10
0.28
3.6
4.0
27.20
34.63
mg/l
0.74
55
491
155
1466
1.06
0.28
1.6
1.5
—
—
—
0
0
26
301
0.86
0.27
1.6
1.6
—
—
—
0
0
26
224
1.16
0.27
1.6
1.8
0.64
1.89
u/field
1.48
11
127
24
279
0.86
0.27
1.5
2.1
—
—
—
0
0
3717
37118
1.11
0.27
21.5
18.8
266.24
266.55
e9/l
0.11
3673
36661
180
1713
1.05
0.26
3.0
2.6
4.76
4.53
kpa
0.64
174
1663
8
66
1.21
0.26
1.8
1.6
13.59
54.58
u/l
—
8
61
12
95
1.26
0.26
1.0
1.3
—
—
—
0
0
5
73
0.68
0.26
2.2
6.3
11.12
11.14
kpa
—
5
73
5
73
0.68
0.26
2.2
6.3
4.75
4.80
kpa
—
5
73
96
897
1.07
0.25
1.2
1.3
895.80
1804.44
e6/l
0.39
69
712
9
73
1.23
0.25
3.3
2.4
153.78
156.39
nmol/l
—
9
66
66
716
0.92
0.25
1.5
1.6
—
—
—
0
0
234
2435
0.96
0.24
2.3
2.3
76.02
75.99
ml/min/173m2
0.01
95
970
29
255
1.14
0.24
1.6
1.7
0.46
2.04
u/ml
—
5
66
108
1018
1.06
0.23
1.2
1.3
439.24
473.55
mg/l
0.41
102
974
22
190
1.16
0.23
1.3
1.7
1.52
2.91
nmol/l
1.03
15
142
55
598
0.92
0.22
1.4
1.4
—
—
—
0
0
70
650
1.08
0.22
2.2
2.1
5.08
5.37
mmol/24h
0.42
65
585
5
40
1.25
0.22
1.6
1.7
—
—
—
0
0
16
189
0.85
0.22
1.4
1.5
0.42
0.49
e9/l
1.12
16
189
21
242
0.87
0.22
1.6
2.4
617.19
530.46
e6/l
0.60
16
185
12
146
0.82
0.22
2.3
1.4
4733.00
64267.01
e6/l
—
5
74
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
18
154
1.17
0.21
1.1
1.3
72.90
265.44
nmol/24h
0.55
18
154
3717
37128
1.09
0.20
21.4
18.7
90.19
90.42
fl
3.03
3701
36943
0
14
0.00
0.20
0.0
1.4
—
24.43
—
0
14
0
14
0.00
0.20
0.0
1.1
—
30.80
—
0
14
427
4168
1.03
0.20
1.6
1.6
3.41
3.45
mmol/l
0.31
297
2758
55
509
1.08
0.20
1.2
1.1
—
—
—
0
0
240
2321
1.04
0.20
1.4
1.4
226.06
238.38
miu/ml
0.21
118
1180
47
432
1.09
0.20
1.2
1.2
0.18
0.17
nmol/l
0.39
36
328
85
801
1.06
0.19
1.8
1.9
—
—
—
0
0
609
5975
1.02
0.19
1.8
1.9
—
—
—
0
0
6
51
1.18
0.19
1.0
1.0
—
—
—
0
0
6
51
1.18
0.19
1.2
1.4
—
—
—
0
0
3717
37130
1.08
0.19
21.5
18.8
6.64
6.70
e9/l
0.96
3666
36600
106
1007
1.05
0.19
1.2
1.3
—
—
—
0
0
10
81
1.24
0.18
1.0
1.4
—
—
—
0
0
10
81
1.24
0.18
1.0
1.4
—
—
—
0
0
3717
37131
1.08
0.18
21.9
19.0
39.63
40.36
%
2.13
3700
36924
28
311
0.90
0.18
5.4
5.6
368.00
367.80
umol/l
0.00
22
266
3717
37132
1.08
0.18
21.5
18.8
4.44
4.44
e12/l
0.04
3663
36625
61
571
1.07
0.17
1.5
1.3
1.24
1.26
nmol/l
0.06
49
496
13
110
1.18
0.17
1.2
1.2
—
—
—
0
0
13
110
1.18
0.17
1.2
1.2
—
—
—
0
0
42
454
0.92
0.16
1.1
1.1
—
—
—
0
0
548
5385
1.02
0.16
1.8
1.8
3.18
3.27
ratio
1.13
419
3913
8
71
1.13
0.16
1.1
1.0
—
—
—
0
0
33
302
1.09
0.16
1.1
1.1
1.00
1.03
u/l
0.33
11
106
132
1372
0.96
0.16
14.8
8.7
1.11
1.31
%
2.06
132
1366
9
79
1.14
0.15
1.2
1.4
—
—
—
0
0
9
80
1.13
0.15
1.1
1.1
—
—
—
0
0
36
389
0.92
0.14
1.5
1.4
—
—
—
0
0
1869
18568
1.01
0.14
2.9
2.7
—
—
estimate
—
0
0
30
327
0.92
0.14
1.3
1.3
—
70.07
—
0
15
7
88
0.80
0.14
1.1
1.3
5.59
5.41
mmol/l
—
7
88
3717
37138
1.07
0.14
21.6
18.9
132.19
132.86
g/l
3.60
3700
36951
10
118
0.85
0.14
1.0
1.0
—
—
—
0
0
10
84
1.19
0.14
1.0
1.0
—
—
—
0
0
55
519
1.06
0.13
2.0
1.7
—
—
—
0
0
24
263
0.91
0.13
5.3
7.0
107.68
110.30
ug/l
0.01
14
161
198
2033
0.97
0.13
11.3
8.0
119.08
120.59
g/l
0.55
190
1984
90
863
1.04
0.13
1.5
1.6
352.68
361.24
mu/l
0.08
71
699
10
117
0.85
0.13
1.1
1.1
1.01
1.29
mom
—
10
117
288
2820
1.02
0.13
1.6
1.5
61.70
60.24
ug/l
0.23
288
2820
268
2622
1.02
0.13
1.6
1.5
—
—
—
0
0
211
2058
1.03
0.12
3.7
3.0
5.73
5.80
kpa
0.47
206
1999
19
171
1.11
0.12
3.4
3.4
—
—
—
0
0
10
85
1.18
0.12
1.0
1.1
—
—
—
0
0
92
885
1.04
0.12
1.2
1.3
5.03
31.21
e6/l
2.49
60
652
77
739
1.04
0.11
2.5
2.0
1.43
1.74
ug/l
0.19
67
667
10
86
1.16
0.11
1.1
1.2
—
—
—
0
0
482
4756
1.02
0.11
1.6
1.8
—
—
—
0
0
31
290
1.07
0.10
1.8
1.9
—
—
—
0
0
234
2295
1.02
0.10
1.4
1.4
—
—
—
0
0
288
2831
1.02
0.10
1.6
1.7
—
—
—
0
0
10
87
1.15
0.09
1.1
1.0
64.74
74.27
ug/l
—
10
75
136
1326
1.03
0.09
1.3
1.5
0.36
0.51
nmol/l
2.61
111
1068
6
54
1.11
0.09
1.2
1.1
—
—
—
0
0
6
54
1.11
0.09
1.0
1.1
—
—
—
0
0
15
165
0.91
0.08
2.2
1.4
1418.60
3184.54
e6/l
—
10
109
65
674
0.96
0.08
1.4
1.4
—
—
—
0
0
65
627
1.04
0.08
1.8
2.1
130.08
129.57
g/l
0.08
53
513
21
195
1.08
0.08
1.1
1.1
—
—
—
0
0
94
966
0.97
0.08
1.2
1.1
—
—
—
0
0
24
256
0.94
0.07
1.5
1.7
—
—
—
0
0
203
1996
1.02
0.07
3.7
3.0
1.74
1.77
mmol/l
0.04
173
1772
6
70
0.86
0.07
1.3
1.6
—
1.03
—
0
7
8
75
1.07
0.07
1.1
1.1
—
—
—
0
0
94
965
0.97
0.07
1.2
1.1
—
—
—
0
0
17
184
0.92
0.07
1.1
1.1
15.43
9.04
u/ml
—
10
132
19
204
0.93
0.07
1.2
1.3
—
—
—
0
0
15
163
0.92
0.07
1.3
1.5
—
—
—
0
0
15
138
1.09
0.06
1.1
1.2
—
—
—
0
0
11
99
1.11
0.06
1.0
1.1
—
—
—
0
0
243
2400
1.01
0.06
10.0
7.3
5.08
5.02
kpa
0.38
233
2319
243
2400
1.01
0.06
10.0
7.3
13.69
13.70
kpa
0.00
233
2314
46
444
1.04
0.06
1.1
1.2
—
—
—
0
0
75
732
1.03
0.05
4.2
2.7
25.04
24.80
mmol/l
0.33
66
680
13
141
0.92
0.05
1.2
1.1
—
—
—
0
0
28
293
0.96
0.05
1.4
1.6
—
—
—
0
0
17
181
0.94
0.05
1.5
1.5
—
—
—
0
0
17
181
0.94
0.05
2.1
1.4
36.94
35.68
g/l
0.15
17
164
36
347
1.04
0.04
1.1
1.1
1.08
1.05
ratio
0.68
31
282
15
160
0.94
0.04
2.7
1.6
—
—
—
0
0
11
101
1.09
0.04
1.7
1.9
—
—
—
0
0
11
101
1.09
0.04
1.7
1.9
—
—
—
0
0
11
101
1.09
0.04
1.2
2.4
43.33
41.28
g/l
1.91
11
101
11
101
1.09
0.04
1.7
1.9
—
—
—
0
0
209
2110
0.99
0.04
10.8
7.7
96.16
96.45
%
0.25
200
2042
34
329
1.03
0.03
1.1
1.2
105.50
118.61
pmol/l
0.97
34
329
220
2219
0.99
0.03
1.3
1.3
—
—
—
0
0
61
621
0.98
0.02
1.1
1.2
179.98
1896.96
pmol/l
—
9
57
63
641
0.98
0.02
3.3
3.4
28.00
20.85
mg/l
0.76
43
426
15
142
1.06
0.02
1.1
1.2
—
—
—
0
0
11
103
1.07
0.02
13.4
15.2
1387.45
1259.67
nmol/l
0.18
11
98
123
1220
1.01
0.01
1.4
1.4
25.59
24.31
u/l
0.16
98
1012
16
153
1.05
0.01
1.1
1.1
—
0.11
—
0
7
237
2380
1.00
0.01
10.1
7.3
0.52
0.82
mmol/l
0.58
195
1933
46
453
1.02
0.01
4.4
7.6
105.20
105.31
mmol/l
0.05
40
407
231
2317
1.00
0.00
2.5
2.2
0.26
0.29
e6/l
0.13
218
2169
25
244
1.02
0.00
1.3
1.6
0.82
1.23
promille
0.82
19
180
1544
15447
1.00
0.00
3.7
3.4
0.06
0.21
estimate
0.56
429
3661
10
98
1.02
0.00
1.4
1.6
8.50
8.61
ug/l
—
10
98
21
208
1.01
0.00
2.1
1.4
4818.21
84192.37
e6/l
1.18
14
134
22
222
0.99
0.00
1.4
1.5
—
—
—
0
0
22
222
0.99
0.00
1.4
1.5
—
—
—
0
0
22
222
0.99
0.00
1.4
1.5
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
17
175
0.97
0.00
1.2
1.1
—
—
—
0
0
73
731
1.00
0.00
1.1
1.1
1.66
4.00
eliau/ml
2.64
38
373
18
184
0.98
0.00
1.4
1.6
117.22
85.43
ng/l
0.35
18
184
46
457
1.01
0.00
3.5
4.7
34.31
80.48
u/ml
—
10
163
10
103
0.97
0.00
1.1
1.0
4.08
5.34
u/ml
—
10
103
10
97
1.03
0.00
7.5
12.1
792.70
690.01
nmol/l
—
10
92
17
173
0.98
0.00
1.5
1.3
5.76
6.38
mmol/l
0.89
17
164
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
31.40
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
4.29
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
87.60
—
0
5
10
100
1.00
-0.00
1.1
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
1.06
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
94
0.96
-0.00
1.9
2.8
15.30
14.90
umol/l
—
9
94
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
5.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint O15_ICP_WIDE_EXMORE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| O15_ICP_WIDE_EXMORE | 0.645 [0.51, 0.82] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.15 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 13316 females with O15_ICP_WIDE_EXMORE died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have O15_ICP_WIDE_EXMORE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.056% | No data |
| 5 | 0.347% | No data |
| 10 | 0.859% | No data |
| 15 | 1.645% | No data |
| 20 | 2.956% | No data |
Relationships between endpoints
↥Index endpoint: O15_ICP_WIDE_EXMORE – Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8, excluding more controls
GWS hits: 31
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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