generalised epilepsy: A chronic condition characterised by recurrent generalised seizures.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditions
|
546410 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
997 |
6. Filter based on genotype QC (FinnGen only) |
885 |
Control definitions (FinnGen only)
- Control exclude
- G6_EPLEPSY
- Control conditions
- not FE
Extra metadata
- First used in FinnGen datafreeze
- DF3
Similar endpoints
↥List of similar endpoints to
Generalized epilepsy, strict definition
based on the number of shared cases.
Similar with more cases:
- Generalized epilepsy
- Episodal and paroxysmal disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13436 | 6594 | 6672 |
| Only index persons | 9660 | 5220 | 4440 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.19 | 0.19 |
| Only index persons | 0.18 | 0.19 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 26.02 | 23.13 | 28.07 |
| Only index persons | 19.95 | 20.03 | 19.87 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 885 | 541 | 344 |
| Unadjusted period prevalence (%) | 0.18 | 0.19 | 0.16 |
| Median age at first event (years) | 25.16 | 23.09 | 28.42 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 932
- Matched controls
- 9320
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R56.8
ICD-10 Finland
Other and unspecified convulsions
32.2
307.7
301
136
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
+∞
307.7
739
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
3323.9
307.7
378
*
N03AG01
ATC
valproic acid; systemic, rectal
48.4
307.7
487
206
N03AX14
ATC
levetiracetam; systemic
102.8
307.7
189
23
G40.39
ICD-10 Finland
Other or unspecified generalized epileptic syndromes with atonic, clonic, myoclonic or tonic-clonic seizures
+∞
307.7
426
*
N03AF01
ATC
carbamazepine; oral, rectal
20.9
249.5
202
122
3451A
ICD-9 Finland
Epilepsy, Generalised convulsive epilepsy
+∞
191.4
177
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
2196.4
183.6
172
*
183
Kela drug reimbursment
Lamotrigin and topiramate
+∞
182.4
169
*
G40.3
ICD-10 Finland
Generalized idiopathic epilepsy and epileptic syndromes
+∞
167.9
156
*
N03AX09
ATC
lamotrigine; oral
9.8
155.9
203
257
G40.30
ICD-10 Finland
Benign myoclonic eplilepsy in infancy
+∞
153.5
143
*
G40
ICD-10 Finland
Epilepsy
1493.8
135.9
129
*
N03AF02
ATC
oxcarbazepine; oral
23.4
134.1
99
47
G40.36
ICD-10 Finland
Juvenile myoclonic epilepsy [impulsive petit mal]
+∞
131.4
123
*
N05BA01
ATC
diazepam; systemic, rectal
5.5
101.0
234
532
N88
ICPC
Epilepsy
+∞
89.0
84
*
7803A
ICD-9 Finland
General symptoms, Convulsions
17.4
81.2
68
42
34519
ICD-8 Finland
Epilepsy, Generalisata convulsiva NUD
+∞
80.4
76
*
G40.4
ICD-10 Finland
Other generalized epilepsy and epileptic syndromes
+∞
78.2
74
*
G40.6
ICD-10 Finland
Grand mal seizures, unspecified (with or without petit mal)
+∞
73.9
70
*
N03AE01
ATC
clonazepam; systemic
6.3
57.4
102
177
G40.35
ICD-10 Finland
Juvenile absence epilepsy
+∞
53.7
51
*
3450A
ICD-9 Finland
Epilepsy, Generalised nonconvulsive epilepsy
+∞
52.6
50
*
G40.33
ICD-10 Finland
Juvenile absence epilepsy
+∞
51.5
49
*
N05CD08
ATC
midazolam; nasal, systemic
11.9
50.4
52
46
N03AD01
ATC
ethosuximide; oral
+∞
49.4
47
*
3459X
ICD-9 Finland
Epilepsy, unspecified
+∞
49.4
47
*
34599
ICD-8 Finland
Epilepsy, Other and unspecified
+∞
47.3
45
*
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
7.8
46.7
67
92
N05BA09
ATC
clobazam; oral
161.1
44.2
46
*
G40.89
ICD-10 Finland
Other epilepsy
+∞
43.1
41
*
N03AB02
ATC
phenytoin; systemic
54.9
39.9
47
9
78020
ICD-8 Finland
Certain symptoms referable to nervous system and special senses, Convulsions
13.8
38.4
36
27
34510
ICD-8 Finland
Epilepsy, """"Grand mal""""
+∞
35.6
34
*
3453A
ICD-9 Finland
Epilepsy, Grand mal status
+∞
28.3
27
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.9
21.7
108
399
N03AX11
ATC
topiramate; oral
4.7
21.5
50
110
XA800
NOMESCO Finland
Neuropsychological investigation
3.6
20.8
71
208
AA1AD
NOMESCO Finland
CT of head and brain
2.2
20.3
224
1195
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.3
20.0
78
249
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.8
17.7
91
341
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.8
17.7
94
359
N05AD01
ATC
haloperidol; systemic
4.9
17.2
38
80
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.6
16.8
107
447
N03AX23
ATC
brivaracetam; systemic
+∞
16.7
16
*
R55
ICD-10 Finland
Syncope and collapse
2.6
15.9
101
421
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
5.4
15.7
31
59
N03AX22
ATC
perampanel; oral
+∞
15.7
15
*
N05AX08
ATC
risperidone; systemic
2.6
15.2
95
393
G41.9
ICD-10 Finland
Status epilepticus, unspecified
36.7
14.5
18
5
N05AA02
ATC
levomepromazine; systemic
3.5
14.4
50
148
N03AX18
ATC
lacosamide; systemic
142.0
13.5
14
*
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
5.0
12.2
26
53
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
11.8
203
1237
G40.37
ICD-10 Finland
Baltic myoclonus
+∞
11.5
11
*
34500
ICD-8 Finland
Epilepsy, """"Petit mal""""
+∞
11.5
11
*
G40.7
ICD-10 Finland
Petit mal, unspecified, without grand mal seizures
+∞
11.5
11
*
R25.2
ICD-10 Finland
Cramp and spasm
3.9
10.8
32
85
Z2445
NOMESCO Finland
Psychologist
2.5
10.5
65
268
G40.31
ICD-10 Finland
Benign neonatal convulsions (familial)
+∞
10.4
10
*
3452A
ICD-9 Finland
Epilepsy, Petit mal status
+∞
10.4
10
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.9
10.2
134
748
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
2.9
10.0
46
162
T36
ICD-10 Finland
Poisoning by systemic antibiotics
2.6
9.6
54
212
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.8
9.6
149
876
N05AH02
ATC
clozapine; systemic
3.7
9.4
30
84
F02.89*G40.9
ICD-10 Finland
Dementia in epilepsy
+∞
9.4
9
*
G40.34
ICD-10 Finland
Epilepsy with grand mal seizures on awakening
+∞
9.4
9
*
N05AH04
ATC
quetiapine; oral
1.7
9.3
187
1187
R56.0
ICD-10 Finland
Febrile convulsions
7.4
9.2
21
29
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
9.1
181
1144
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
8.9
123
698
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.0
8.8
103
551
N06AB04
ATC
citalopram; systemic
1.7
8.8
164
1017
XA400
NOMESCO Finland
EEG
10.8
8.8
16
15
4380A
ICD-9 Finland
Late effects of cerebrovascular disease[SEQUELAE MORBI CEREBROVASCULARIS]
27.8
8.5
11
*
N05AH03
ATC
olanzapine; systemic
2.2
8.4
75
364
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.3
8.3
65
298
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
8.3
192
1261
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.1
8.3
82
413
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.3
8.3
66
305
N05CD07
ATC
temazepam; oral
2.1
7.9
72
351
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.1
7.8
78
394
N03AA02
ATC
phenobarbital; systemic
45.4
7.7
9
*
F29
ICD-10 Finland
Unspecified nonorganic psychosis
2.4
7.7
52
224
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
4.6
7.7
18
40
7802X
ICD-9 Finland
General symptoms, Syncope and collapse[SYNCOPE ET COLLAPSUS NUD]
13.5
7.4
12
9
Y0209
ICD-8 Finland
Examination of the nervous system and sensory organs, Nervous system
11.0
7.3
13
12
G40.59
ICD-10 Finland
Other special epileptic syndromes
+∞
7.3
7
*
34598
ICD-8 Finland
Epilepsy, Alia definita
+∞
7.3
7
*
F41.09
ICD-10 Finland
UNS Panic Syndrome
2.6
7.3
41
162
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
6.3
7.3
18
29
C03CA01
ATC
furosemide; systemic
1.7
7.2
159
1031
N03AX15
ATC
zonisamide; oral
30.3
7.2
9
*
N05AB03
ATC
perphenazine; systemic, rectal
2.8
7.0
33
119
N05AF03
ATC
chlorprothixene; systemic
3.1
6.9
28
92
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.1
6.9
28
92
IGY02
NOMESCO Finland
Psychiatric monitoring contact
2.2
6.9
57
268
N04AA02
ATC
biperiden; systemic
3.4
6.9
24
72
A04
ICPC
Weakness/tiredness general
1.6
6.9
152
985
A10AB01
ATC
insulin (human); parenteral
2.6
6.8
39
155
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.3
6.8
48
211
2402
FHL
External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)
6.2
6.8
17
28
Z3231
NOMESCO Finland
Registered nurse
1.5
6.6
228
1636
R40.2
ICD-10 Finland
Coma, unspecified
10.1
6.5
12
12
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
3.3
6.5
24
75
G41.0
ICD-10 Finland
Grand mal status epilepticus
70.3
6.4
7
*
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
1.7
6.4
138
887
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
1.9
6.3
78
426
4340A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral thrombosis
11.1
6.3
11
10
N07
ICPC
Convulsion/seizure
18.2
6.3
9
5
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
6.2
333
2602
R42
ICD-10 Finland
Dizziness and giddiness
1.6
6.1
160
1078
N05BA04
ATC
oxazepam; oral
1.5
6.1
203
1443
R11
ICD-10 Finland
Nausea and vomiting
1.8
6.1
89
514
E9509
ICD-8 Finland
Suicide and self-inflicted poisoning by solid or liquid substances, Other and unspecified solid and liquid substances
10.1
6.0
11
11
C07AA05
ATC
propranolol; systemic
1.5
6.0
181
1259
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
5.6
6.0
16
29
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
226
86
34.37
307.65
4.7
6.9
393.18
374.59
umol/l
0.50
211
78
55
23
25.35
77.67
3.4
1.9
16.48
14.96
umol/l
0.38
55
23
334
1922
2.15
25.75
2.6
2.0
186.84
219.02
u/l
0.38
326
1839
475
3429
1.79
16.58
6.6
8.2
1.21
1.22
mmol/l
0.89
420
3031
558
4281
1.76
15.23
5.4
5.6
6.48
6.47
mmol/l
0.04
522
3970
421
3062
1.68
13.31
6.1
8.1
1.21
1.22
mmol/l
1.09
398
2850
126
727
1.85
8.61
2.7
2.5
27.82
39.08
u/l
2.38
110
598
180
1182
1.65
7.76
1.8
1.8
1.43
1.42
%
0.04
166
1073
351
2721
1.47
7.04
3.8
3.5
31.02
31.19
u/l
0.03
333
2595
307
2365
1.44
6.19
3.1
3.2
18.33
58.41
ng/l
0.75
162
1359
291
2250
1.43
5.66
2.6
2.6
54.27
62.37
u/l
1.31
271
2105
242
1818
1.45
5.48
1.7
1.6
21.26
20.34
nmol/l
0.39
216
1595
364
2940
1.39
5.46
4.8
5.5
36.45
36.91
g/l
0.83
342
2779
357
2880
1.39
5.37
2.1
1.9
98.64
96.71
pmol/l
0.31
191
1559
533
4605
1.37
5.16
10.6
9.6
3.92
3.95
e9/l
0.13
457
3987
174
1241
1.49
5.10
3.7
3.4
140.62
681.76
ng/l
2.61
115
803
124
822
1.59
5.07
4.3
6.5
5.70
5.78
kpa
0.46
116
802
121
799
1.59
5.03
4.4
6.6
1.01
1.46
mmol/l
0.59
106
669
621
5511
1.38
5.00
7.4
7.5
77.02
82.04
u/l
2.45
580
5248
433
3700
1.32
4.15
6.2
6.4
9.97
12.50
umol/l
2.34
406
3526
290
2349
1.34
4.01
3.6
3.6
7.20
8.24
mmol/l
2.98
247
2072
288
2337
1.34
3.92
2.6
3.0
2.35
2.36
mmol/l
0.64
267
2151
806
7589
1.46
3.80
17.5
14.3
139.30
139.61
mmol/l
2.84
787
7441
61
368
1.70
3.65
1.6
1.6
—
—
—
0
0
14
40
3.54
3.61
1.9
5.0
236.33
171.41
umol/l
—
6
22
100
683
1.52
3.60
2.5
3.1
0.24
0.22
g/l
1.43
95
649
331
2778
1.30
3.46
11.0
10.2
1.15
1.16
inr
0.17
277
2317
404
3481
1.28
3.44
2.7
2.7
73.68
72.79
nmol/l
0.21
371
3254
804
7603
1.42
3.35
17.4
14.4
3.96
3.94
mmol/l
1.65
782
7435
93
641
1.50
3.23
4.7
7.1
5.16
5.05
kpa
0.92
87
622
85
580
1.51
3.10
4.5
7.4
0.78
1.29
mmol/l
0.88
63
426
47
277
1.73
3.09
1.1
1.1
1.27
7.58
eliau/ml
—
8
49
67
434
1.59
3.08
2.0
1.7
0.25
0.32
mg/l
0.56
32
186
34
183
1.89
2.99
3.4
3.0
5.44
4.81
index
0.06
16
103
611
5590
1.27
2.99
4.2
3.4
46.29
39.82
u/l
1.56
592
5373
144
1092
1.38
2.99
1.9
1.9
—
—
—
0
0
92
646
1.47
2.93
8.1
11.2
1.26
0.65
mmol/l
0.59
81
540
101
725
1.44
2.87
3.7
6.4
4.80
4.81
kpa
0.02
93
707
215
1761
1.29
2.62
1.8
2.1
1.66
1.21
mg/l
0.32
156
1331
194
1569
1.30
2.60
2.6
3.5
733.69
991.60
ng/l
0.89
150
1308
90
645
1.44
2.60
2.1
2.4
7838.76
7078.83
u/l
0.06
35
285
33
191
1.75
2.36
1.7
2.1
1.88
10.21
e6/l
1.38
24
140
56
372
1.54
2.36
1.3
1.4
—
—
—
0
0
225
1877
1.26
2.35
4.8
4.5
96.36
92.14
%
1.93
220
1838
227
1901
1.26
2.29
3.6
3.3
1.02
1.02
kg/l
0.06
159
1238
33
194
1.73
2.25
1.7
2.1
69.84
249.34
e6/l
0.89
25
149
105
795
1.36
2.23
1.9
1.8
—
—
—
0
0
85
623
1.40
2.20
6.6
11.6
1.52
1.35
mmol/l
0.78
85
610
71
504
1.44
2.19
1.5
1.5
292.75
288.61
mu/l
0.06
63
456
7
19
3.70
2.15
7.6
4.6
8.83
11.18
kpa
—
7
19
7
19
3.70
2.15
7.6
4.6
5.60
4.64
kpa
—
7
19
32
190
1.71
2.12
1.2
2.0
3.72
3.62
mmol/l
0.21
32
180
10
37
2.72
2.07
1.2
1.2
—
—
—
0
0
10
37
2.72
2.07
1.2
1.2
—
—
—
0
0
279
2416
1.22
2.05
1.6
1.5
2.19
1.90
u/ml
0.13
62
660
28
162
1.75
2.04
1.1
1.2
79.20
144.51
iu/ml
—
5
48
10
38
2.65
2.01
1.6
1.6
—
—
—
0
0
10
38
2.65
2.01
1.6
1.6
—
—
—
0
0
10
38
2.65
2.01
1.6
1.6
—
—
—
0
0
10
38
2.65
2.01
1.6
1.6
—
—
—
0
0
237
2026
1.23
1.97
2.1
2.4
2.51
2.72
mg/l
0.83
199
1765
25
142
1.78
1.94
1.1
1.2
2.11
4.23
u/ml
—
9
52
5
11
4.56
1.94
1.0
1.1
70.40
58.18
titre
—
5
11
6
16
3.77
1.93
2.7
2.1
42.80
44.01
g/l
—
6
16
116
913
1.31
1.92
1.8
1.7
1030.22
1160.75
nmol/l
0.94
87
706
5
12
4.18
1.82
1.2
1.3
—
—
—
0
0
17
87
1.97
1.80
1.4
1.3
—
—
—
0
0
15
74
2.04
1.75
1.0
1.1
175.67
233.58
mg/l
0.91
15
63
75
562
1.36
1.74
2.3
2.3
22.38
15.20
au/ml
—
5
59
838
8124
1.31
1.74
12.3
10.4
26.24
26.53
u/l
0.18
813
7945
850
8695
0.75
1.71
26.2
19.9
135.52
136.17
g/l
0.71
844
8631
16
82
1.97
1.70
1.4
1.3
—
—
—
0
0
204
1743
1.22
1.69
2.4
2.8
326.48
330.61
umol/l
0.22
176
1583
34
220
1.57
1.67
1.3
1.4
301.72
309.48
ug/g
0.07
18
125
16
83
1.94
1.65
1.4
1.3
—
—
—
0
0
16
83
1.94
1.65
1.4
1.3
—
—
—
0
0
850
8690
0.75
1.63
26.5
20.3
40.22
40.57
%
1.28
844
8622
850
8690
0.75
1.63
26.0
19.7
4.52
4.56
e12/l
1.91
832
8522
24
143
1.70
1.62
1.1
1.2
2.25
5.33
u/ml
—
8
66
850
8687
0.76
1.58
25.9
19.6
89.97
89.84
fl
0.32
844
8628
16
85
1.90
1.55
1.4
1.3
—
—
—
0
0
70
912
0.75
1.55
1.5
1.6
3.62
3.50
mmol/l
0.41
47
631
850
8684
0.76
1.54
26.1
19.7
252.46
258.21
e9/l
1.93
831
8536
97
770
1.29
1.54
1.9
1.9
—
—
—
0
0
7
27
2.60
1.51
1.9
1.8
—
—
—
0
0
7
27
2.60
1.51
1.9
1.8
—
—
—
0
0
7
27
2.60
1.51
1.6
2.1
199.29
200.56
u/l
—
7
27
5
126
0.39
1.50
1.0
1.5
—
—
—
0
0
30
194
1.56
1.50
1.7
2.2
2.59
2.93
g/l
1.09
30
185
26
402
0.64
1.48
1.5
1.9
3.24
3.59
mg/l
0.20
16
278
31
203
1.55
1.47
1.7
2.2
6.85
7.19
g/l
0.67
31
194
31
203
1.55
1.47
1.7
2.2
4.33
4.30
g/l
0.05
31
194
31
203
1.55
1.47
1.7
2.2
3.66
3.76
g/l
0.15
31
194
537
5028
1.16
1.46
4.4
4.1
656.83
710.24
e6/l
0.04
12
75
710
7381
0.84
1.46
5.1
4.7
2.82
2.79
mmol/l
0.31
671
7033
701
7295
0.84
1.45
4.6
4.3
1.42
1.45
mmol/l
1.16
661
6945
705
7333
0.84
1.45
4.7
4.4
4.69
4.68
mmol/l
0.12
666
7014
7
28
2.51
1.45
1.9
1.8
—
—
—
0
0
73
935
0.76
1.44
2.1
2.7
0.79
0.74
ug/l
0.14
43
500
91
724
1.28
1.43
2.4
4.8
228.69
259.43
u/l
1.49
86
697
124
1026
1.24
1.41
5.6
7.7
1.16
1.12
mmol/l
0.55
119
964
50
367
1.38
1.36
7.8
13.8
24.08
24.18
mmol/l
0.06
50
360
121
1007
1.23
1.31
2.3
2.6
25.92
23.45
%
1.11
114
955
78
616
1.29
1.31
1.0
1.1
—
—
—
0
0
6
24
2.51
1.30
1.2
1.2
—
—
—
0
0
9
43
2.10
1.30
1.0
1.0
—
—
—
0
0
652
6220
1.16
1.30
4.8
4.3
14.28
14.53
pmol/l
1.82
602
5819
13
69
1.90
1.29
1.1
1.1
—
—
—
0
0
241
2144
1.17
1.27
1.5
1.5
2.29
2.15
g/l
0.46
130
1355
101
1221
0.81
1.26
3.3
3.7
20.54
22.19
%
0.50
34
479
214
1887
1.17
1.26
4.8
4.2
16.05
19.11
mg/mmol
0.11
139
1223
14
77
1.83
1.26
1.2
1.5
4.07
5.53
u/ml
—
9
45
43
313
1.39
1.24
1.1
1.2
4.19
7.14
u/ml
0.63
20
200
22
139
1.60
1.24
2.4
3.4
6.39
7.64
pmol/l
0.41
22
139
67
525
1.30
1.21
1.2
1.4
—
—
—
0
0
23
148
1.57
1.21
6.3
3.8
20.73
30.68
mg/l
1.13
16
112
132
1120
1.21
1.20
2.3
2.6
2.43
2.42
g/l
0.08
123
1040
22
141
1.57
1.18
1.1
1.1
—
—
—
0
0
31
437
0.70
1.16
1.5
1.6
—
—
—
0
0
15
87
1.74
1.15
1.4
1.3
—
—
—
0
0
8
39
2.06
1.15
1.4
1.6
—
—
—
0
0
30
209
1.45
1.11
3.0
2.0
0.76
2.32
ug/l
0.61
22
187
62
488
1.29
1.10
1.6
1.7
—
—
—
0
0
65
516
1.28
1.08
3.4
5.1
86.87
76.29
ng/l
0.33
55
472
666
6906
0.88
1.06
3.9
3.7
1.34
1.25
mmol/l
2.14
628
6549
134
1545
0.85
1.04
3.4
4.3
1.67
1.89
ug/l
0.31
121
1420
5
22
2.28
1.03
1.0
1.5
13.36
8.03
ug/l
—
5
22
136
1564
0.85
1.02
1.5
1.5
—
—
—
0
0
98
822
1.21
1.02
1.7
2.1
407.93
375.41
nmol/l
0.73
89
781
17
107
1.60
1.00
1.2
1.3
—
—
—
0
0
34
250
1.37
0.97
1.9
1.8
—
—
—
0
0
12
69
1.75
0.96
1.0
1.0
—
—
—
0
0
22
150
1.48
0.93
1.7
1.4
729.24
349.56
mu/l
0.82
17
124
75
619
1.23
0.93
1.5
1.5
21.47
21.21
iu/l
0.03
63
507
137
1197
1.17
0.92
2.3
2.6
14.91
14.04
umol/l
0.72
128
1127
6
28
2.15
0.91
1.0
1.0
222.67
238.61
ng/l
—
6
18
6
28
2.15
0.91
1.2
1.2
—
—
—
0
0
6
28
2.15
0.91
1.2
1.2
—
—
—
0
0
6
28
2.15
0.91
1.0
1.0
1026.50
692.67
ng/l
—
6
18
137
1198
1.17
0.91
2.3
3.1
6.50
2.75
e6/l
0.95
59
570
25
176
1.43
0.91
1.4
2.2
10.56
10.36
g/l
0.10
25
166
21
143
1.48
0.90
1.6
3.1
1.25
2.03
ratio
—
9
83
40
307
1.32
0.88
1.1
1.1
0.24
1.47
u/ml
1.93
18
162
106
910
1.19
0.88
3.2
3.6
5.19
7.26
umol/l
1.21
86
782
8
43
1.87
0.87
1.6
3.0
625.88
1371.47
mg
—
8
43
19
128
1.49
0.86
1.6
2.2
—
1291.43
—
0
7
45
353
1.29
0.86
1.6
1.9
9.51
5.96
iu/ml
—
8
81
63
516
1.24
0.85
1.5
1.4
—
—
—
0
0
135
1189
1.16
0.83
2.3
2.5
2.42
2.43
mmol/l
0.29
119
1053
17
113
1.51
0.82
1.9
1.9
—
—
—
0
0
6
32
1.88
0.82
1.0
3.2
78.00
114.35
ug/l
—
6
32
33
250
1.33
0.81
1.6
1.2
17.26
7.80
u/ml
—
8
34
0
25
0.00
0.79
0.0
1.2
—
0.33
—
0
25
720
7003
1.12
0.78
13.2
11.4
94.62
90.82
ml/min/173m2
4.71
632
6267
41
324
1.28
0.76
3.0
3.1
1.02
1.02
ratio
0.60
35
300
10
59
1.70
0.76
1.1
1.2
118.90
104.97
pmol/l
—
10
59
582
5603
1.10
0.75
4.1
4.2
10.18
9.56
mm/h
0.53
544
5289
29
378
0.76
0.73
1.9
1.8
—
—
—
0
0
800
7841
1.14
0.73
16.4
12.9
21.55
21.89
mg/l
0.10
673
6294
6
109
0.55
0.72
1.2
1.6
—
—
—
0
0
11
68
1.63
0.72
3.7
1.9
33.73
32.78
pg
0.39
11
68
11
68
1.63
0.72
1.0
1.2
—
—
—
0
0
40
318
1.27
0.71
1.7
1.7
13.29
6.68
u/ml
—
7
78
21
151
1.40
0.71
1.4
2.3
0.00
0.00
g/l
-0.00
21
144
147
1319
1.14
0.71
2.1
2.9
65.95
103.38
ug/g
3.34
108
1072
30
230
1.31
0.70
1.3
1.3
—
—
—
0
0
742
7247
1.12
0.68
5.8
5.2
1.85
1.81
mu/l
0.46
702
6872
11
69
1.60
0.68
1.0
1.2
—
—
—
0
0
50
412
1.23
0.67
1.5
1.7
8.38
8.30
u/l
0.02
38
313
141
1268
1.13
0.67
2.3
2.9
1.14
0.84
e6/l
0.56
63
638
31
241
1.30
0.66
1.1
1.1
6.60
8.17
u/ml
0.12
16
123
10
62
1.62
0.65
1.6
1.6
—
—
—
0
0
10
62
1.62
0.65
1.6
1.6
—
—
—
0
0
10
62
1.62
0.65
1.6
1.6
—
—
—
0
0
33
415
0.79
0.65
1.1
1.1
0.91
0.89
g/l
0.20
33
415
86
751
1.16
0.62
1.3
1.3
170.70
151.90
u/ml
0.12
25
300
51
425
1.21
0.62
2.0
2.2
11.32
7.94
ug/l
0.17
40
386
152
1380
1.12
0.62
1.3
1.3
3.00
10.17
u/ml
2.34
51
540
11
71
1.56
0.62
4.4
2.5
106.00
105.77
mmol/l
0.09
11
71
11
71
1.56
0.62
4.4
2.5
1.22
1.19
mmol/l
1.03
11
71
5
30
1.67
0.61
1.6
2.0
124.80
120.09
ng/l
—
5
30
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
11
72
1.53
0.59
4.4
2.5
4.09
4.04
mmol/l
0.17
11
72
29
228
1.28
0.59
1.7
1.6
—
—
—
0
0
10
64
1.57
0.58
2.0
1.5
—
—
—
0
0
42
346
1.22
0.58
1.2
1.2
1.79
3.04
u/ml
0.53
20
200
33
407
0.80
0.57
1.0
1.1
1.51
1.52
g/l
0.07
33
407
143
1302
1.12
0.57
1.7
1.7
432.07
32753037.90
pmol/l
1.49
121
1148
207
2225
0.91
0.56
3.3
3.5
0.00
0.01
estimate
1.34
66
802
5
87
0.57
0.56
2.4
1.9
—
—
—
0
0
12
82
1.47
0.54
2.0
2.1
—
—
—
0
0
29
231
1.26
0.54
1.0
1.1
0.12
0.32
u/ml
—
9
90
6
40
1.50
0.51
1.7
1.3
—
52.86
—
0
7
43
361
1.20
0.51
4.1
5.7
0.60
0.62
%
0.12
43
361
28
224
1.26
0.51
1.5
1.3
—
—
—
0
0
107
1183
0.89
0.51
1.7
1.8
3.65
3.54
ratio
0.38
84
895
15
202
0.74
0.50
1.6
2.0
—
—
—
0
0
6
41
1.47
0.50
1.0
1.0
—
—
—
0
0
7
107
0.65
0.49
2.0
1.7
—
—
—
0
0
20
154
1.31
0.48
2.3
2.0
—
—
—
0
0
37
308
1.21
0.48
1.2
1.1
0.96
2.49
u/ml
1.18
18
180
438
4219
1.07
0.48
3.6
3.5
0.00
5.36
estimate
1.08
75
848
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
46
1.53
0.48
1.0
1.1
—
—
—
0
0
17
128
1.33
0.48
1.4
1.3
—
—
—
0
0
31
254
1.23
0.47
1.0
1.1
1.20
6.53
u/ml
4.06
19
145
7
48
1.46
0.47
2.9
2.6
—
—
—
0
0
7
48
1.46
0.47
1.1
1.2
—
—
—
0
0
203
1902
1.09
0.46
2.5
2.3
—
—
—
0
0
187
1746
1.09
0.46
2.4
2.2
—
—
—
0
0
8
120
0.66
0.45
1.3
1.6
—
—
—
0
0
15
198
0.75
0.45
1.3
1.5
—
—
—
0
0
161
1495
1.09
0.45
1.3
1.3
25.37
25.96
iu/ml
0.02
49
429
10
141
0.71
0.45
1.7
1.8
—
—
—
0
0
17
131
1.30
0.42
2.2
2.4
32.62
106.28
ug/min
—
9
77
0
17
0.00
0.40
0.0
1.2
—
—
—
0
0
0
17
0.00
0.40
0.0
2.8
—
31.65
—
0
17
40
464
0.86
0.40
1.4
1.3
230.54
253.46
miu/ml
0.19
21
228
28
232
1.21
0.40
1.1
1.2
—
—
—
0
0
5
35
1.43
0.39
1.0
1.3
—
—
—
0
0
10
71
1.41
0.39
1.3
1.2
—
28.80
—
0
5
22
178
1.24
0.39
1.1
1.1
3.47
1.94
eliau/ml
—
9
76
314
3011
1.06
0.39
2.0
1.9
1.56
1.37
mmol/l
1.88
268
2664
439
4256
1.06
0.38
3.7
3.6
0.00
0.39
estimate
0.52
72
803
28
332
0.84
0.37
1.4
1.6
58.96
56.75
ug/l
0.09
28
332
9
70
1.29
0.36
2.1
1.6
0.54
0.50
e9/l
—
9
70
23
189
1.22
0.36
1.4
1.4
—
—
—
0
0
12
90
1.34
0.36
1.0
1.1
—
—
—
0
0
80
730
1.10
0.34
4.8
3.9
32.23
31.65
%
0.15
56
535
6
46
1.31
0.33
1.0
1.1
—
—
—
0
0
19
231
0.82
0.33
1.7
1.8
—
—
—
0
0
38
332
1.15
0.32
1.4
1.3
—
—
—
0
0
12
92
1.31
0.32
1.0
1.1
—
—
—
0
0
27
230
1.18
0.31
1.1
1.2
—
—
—
0
0
7
96
0.73
0.31
1.1
1.1
—
—
—
0
0
7
53
1.32
0.31
8.6
3.5
0.43
0.79
index
—
7
53
824
8164
1.08
0.30
18.0
15.2
70.22
71.75
umol/l
0.63
814
8073
348
3588
0.95
0.29
3.2
2.9
—
—
estimate
—
0
0
29
333
0.87
0.28
1.5
1.4
—
—
—
0
0
96
1029
0.93
0.28
2.3
2.0
—
—
—
0
0
663
6726
0.95
0.28
6.3
5.2
38.94
37.96
mmol/mol
1.45
623
6424
244
2347
1.05
0.28
2.8
3.4
40.54
76.50
e6/l
0.53
185
1747
76
703
1.09
0.26
2.3
2.3
10.51
12.80
nmol/l
1.59
65
653
41
367
1.12
0.26
1.7
1.7
—
—
—
0
0
58
530
1.10
0.26
2.6
3.7
4.56
4.74
pmol/l
0.71
51
477
49
444
1.11
0.26
3.0
2.7
67.52
67.32
g/l
0.06
49
417
84
901
0.93
0.25
1.4
1.6
1116.05
985.38
mu/l
0.46
73
767
52
473
1.11
0.25
3.7
3.5
1.23
1.23
mmol/l
0.01
46
400
29
330
0.87
0.25
1.4
1.6
—
—
—
0
0
38
423
0.89
0.24
2.1
1.9
—
—
—
0
0
428
4185
1.04
0.24
3.6
3.5
0.00
0.00
estimate
0.50
75
846
11
87
1.27
0.24
1.0
1.1
—
—
—
0
0
11
87
1.27
0.24
1.5
1.6
24.71
37.77
nmol/l
0.63
11
77
17
201
0.84
0.24
1.5
1.5
—
—
—
0
0
625
6336
0.96
0.23
3.8
3.7
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
17
144
1.18
0.22
3.8
4.9
0.27
0.34
iu/ml
—
7
78
24
273
0.88
0.22
1.4
1.6
290.21
201.87
u/ml
0.52
14
149
194
1869
1.05
0.21
2.5
2.3
—
—
—
0
0
10
124
0.80
0.21
1.7
1.7
9.02
7.67
mmol/l
—
10
118
16
135
1.19
0.21
1.6
1.5
—
—
—
0
0
33
296
1.12
0.21
1.5
1.5
0.08
0.25
iu/ml
—
10
46
0
11
0.00
0.21
0.0
3.4
—
0.45
—
0
11
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
10.8
—
24.40
—
0
10
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
16
188
0.85
0.21
3.2
2.6
—
—
—
0
0
0
12
0.00
0.21
0.0
9.3
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
2.64
—
0
5
39
354
1.11
0.21
1.4
1.4
—
—
—
0
0
12
145
0.83
0.21
1.2
1.2
—
—
—
0
0
5
43
1.16
0.21
1.0
1.5
—
—
—
0
0
70
655
1.07
0.20
4.2
5.8
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
1.46
—
0
14
17
146
1.17
0.19
1.2
1.3
—
—
—
0
0
17
146
1.17
0.19
1.2
1.3
—
—
—
0
0
10
122
0.82
0.19
1.0
1.1
—
1.38
—
0
5
6
53
1.13
0.18
1.2
1.1
1648.83
1555.06
miu/ml
—
6
53
37
338
1.10
0.18
1.7
2.3
50.47
39.72
u/l
1.97
32
314
12
101
1.19
0.16
1.1
1.5
—
—
—
0
0
65
615
1.06
0.15
2.7
2.8
—
—
—
0
0
208
2027
1.03
0.14
2.7
3.3
0.33
0.32
e6/l
0.06
152
1435
7
89
0.78
0.14
1.1
1.2
—
—
—
0
0
8
98
0.81
0.13
1.1
1.2
—
—
—
0
0
15
132
1.14
0.13
1.1
1.7
85.33
25.56
ng/l
0.46
15
132
12
104
1.16
0.12
1.8
1.6
—
—
—
0
0
14
157
0.89
0.11
1.1
1.3
—
—
—
0
0
314
3184
0.98
0.10
3.4
3.3
0.05
0.04
estimate
0.10
62
709
30
281
1.07
0.09
1.5
1.6
0.20
0.24
g/l
1.22
25
269
5
46
1.09
0.09
1.2
1.1
—
—
—
0
0
16
145
1.11
0.09
1.1
1.5
—
—
—
0
0
5
62
0.81
0.08
1.4
1.2
—
—
—
0
0
20
185
1.08
0.08
1.2
1.5
—
—
—
0
0
13
117
1.11
0.08
1.3
1.1
21.93
16.36
u/ml
—
7
47
701
6976
1.02
0.08
21.6
16.2
13.23
13.37
%
2.35
693
6913
7
82
0.85
0.07
1.1
1.2
—
—
—
0
0
7
83
0.84
0.07
1.1
1.2
—
—
—
0
0
7
85
0.82
0.07
1.1
1.2
—
—
—
0
0
7
85
0.82
0.07
1.1
1.2
—
—
—
0
0
240
2426
0.99
0.05
2.0
1.8
—
—
—
0
0
13
141
0.92
0.05
1.2
1.5
—
—
—
0
0
17
159
1.07
0.05
1.3
1.2
—
—
—
0
0
158
1560
1.02
0.04
2.3
2.8
7.92
6.72
e6/l
0.33
138
1411
120
1218
0.98
0.04
2.6
2.2
—
—
—
0
0
49
478
1.03
0.03
1.3
1.5
1.29
1.20
ratio
0.18
29
301
49
478
1.03
0.03
1.3
1.5
0.89
0.95
ratio
0.92
28
300
49
478
1.03
0.03
1.3
1.5
1.25
1.18
ratio
0.22
28
300
70
687
1.02
0.03
1.4
1.3
118.73
256.65
u/ml
1.86
63
644
243
2412
1.01
0.03
3.0
2.9
0.05
0.05
estimate
0.01
60
694
27
260
1.04
0.03
1.2
1.2
—
—
—
0
0
30
290
1.04
0.03
1.4
1.6
1.11
1.18
g/l
0.47
25
276
48
469
1.02
0.03
1.3
1.5
—
—
—
0
0
433
4312
1.01
0.03
3.4
3.3
120.36
88.33
ug/l
0.97
410
4115
53
540
0.98
0.02
2.1
2.7
78.65
73.66
ml/min/173m2
0.37
20
219
23
222
1.04
0.02
1.4
1.7
—
—
—
0
0
51
503
1.01
0.01
4.6
4.3
3.46
37.31
ug/l
1.32
42
413
52
513
1.01
0.01
1.3
1.5
65.09
62.48
ug/l
0.18
45
443
59
583
1.01
0.01
1.5
1.4
—
—
—
0
0
17
164
1.04
0.00
3.5
5.6
—
2073.00
—
0
14
10
104
0.96
0.00
1.2
1.6
—
—
—
0
0
11
108
1.02
0.00
1.0
1.4
—
—
—
0
0
698
6982
1.00
0.00
4.6
4.1
5.80
5.75
mmol/l
0.45
653
6550
16
161
0.99
0.00
1.5
1.3
6.84
19.27
u/l
—
10
135
23
227
1.01
0.00
1.1
1.1
14.15
16.31
au/ml
—
6
61
6
66
0.91
0.00
2.3
1.7
—
—
—
0
0
7
76
0.92
0.00
1.1
1.3
1.36
1.42
nmol/l
—
7
70
0
8
0.00
-0.00
0.0
6.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
5.82
—
0
9
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
4.0
—
3.30
—
0
8
0
6
0.00
-0.00
0.0
14.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
8
87
0.92
-0.00
4.4
2.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.00
—
0
5
0
6
0.00
-0.00
0.0
6.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint GE_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GE_STRICT | 3.042 [2.55, 3.62] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.156 |
During the follow-up period (1.1.1998 — 31.12.2019), 311 out of 3730 females with GE_STRICT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GE_STRICT | 2.983 [2.53, 3.52] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 387 out of 3234 males with GE_STRICT died.
Mortality risk
Mortality risk for people of age
years, who have GE_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.259% | 0.522% |
| 5 | 1.7% | 3.308% |
| 10 | 4.063% | 8.705% |
| 15 | 8.056% | 15.884% |
| 20 | 14.044% | 25.461% |
Relationships between endpoints
↥Index endpoint: GE_STRICT – Generalized epilepsy, strict definition
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data