thyroid disease: A disease involving the thyroid gland.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
558 |
4. Check minimum number of eventsNone |
558 |
5. Include endpointsNone |
558 |
6. Filter based on genotype QC (FinnGen only) |
497 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorder of thyroid, unspecified
based on the number of shared cases.
Similar with more cases:
- Other disorders of thyroid
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3547 | 2760 | 749 |
| Only index persons | 2885 | 2275 | 610 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.08 | 0.02 |
| Only index persons | 0.07 | 0.08 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 47.04 | 46.23 | 49.67 |
| Only index persons | 43.39 | 42.46 | 46.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 497 | 408 | 89 |
| Unadjusted period prevalence (%) | 0.13 | 0.14 | 0.04 |
| Median age at first event (years) | 46.21 | 44.75 | 52.91 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 516
- Matched controls
- 5160
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H03AA01
ATC
levothyroxine sodium; systemic
91.9
307.7
268
60
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
157.7
295.9
147
13
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
4480.1
256.5
226
*
24599
ICD-8 Finland
Thyroiditis, Unspecified
+∞
156.4
142
*
104
Kela drug reimbursment
Thyroid insufficiency
496.6
122.2
117
*
E07.89
ICD-10 Finland
Other specified disorders of thyroid
+∞
111.6
103
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
119.2
67.8
72
7
E03.89
ICD-10 Finland
Other specified hypothyroidism
374.6
66.1
65
*
E03
ICD-10 Finland
Other hypothyroidism
159.8
55.1
57
*
T86
ICPC
Hypothyroidism/myxoedema
95.0
54.2
59
7
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
264.0
47.9
48
*
BAA60
NOMESCO Finland
Total thyroidectomy
+∞
44.4
42
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
42.3
40
*
H03BB01
ATC
carbimazole; oral
120.0
41.4
44
*
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
45.6
34.6
42
10
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
82.0
34.3
38
5
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
31.6
30
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.5
28.4
59
119
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
285.2
27.0
27
*
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
25.9
24.7
34
14
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
+∞
22.0
21
*
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
+∞
17.8
17
*
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
32.7
17.2
22
7
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
16.8
16
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
+∞
15.7
15
*
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
+∞
15.7
15
*
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
+∞
14.6
14
*
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
154.2
14.5
15
*
24409
ICD-8 Finland
Myxoedema, (hypothyreosis) NUD
154.2
14.5
15
*
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
11.8
14.4
26
23
E07.81
ICD-10 Finland
Pituitary thyroxin resistence
+∞
13.6
13
*
2469X
ICD-9 Finland
Other disorders of thyroid, Unspecified disorder of thyroid
+∞
11.5
11
*
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
+∞
10.4
10
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
10.4
10
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
10.4
10
*
E07.82
ICD-10 Finland
Disorder of thyroid function caused by general disease state
+∞
10.4
10
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
10.3
211
1398
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
10.0
215
1445
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
56.1
9.7
11
*
2504
FHL
Unilateral resection or enucleation
101.8
9.4
10
*
E07.8
ICD-10 Finland
Other specified disorders of thyroid
+∞
9.4
9
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
9.4
89
449
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
3.6
8.9
30
88
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
50.9
8.7
10
*
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
+∞
8.4
8
*
A04
ICPC
Weakness/tiredness general
2.0
8.3
95
513
R53
ICD-10 Finland
Malaise and fatigue
1.8
7.8
144
912
R49.08
ICD-10 Finland
Other specified dysphonia
3.9
7.3
21
55
E06.9
ICD-10 Finland
Thyroiditis, unspecified
+∞
7.3
7
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.7
7.2
171
1158
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
7.2
153
1006
BA1AE, ,
SPAT
12.2
7.1
12
10
R06.0
ICD-10 Finland
Dyspnoea
1.7
7.0
152
1003
R21
ICPC
Throat symptom/complaint
1.8
7.0
118
724
WX402
NOMESCO Finland
General anaesthesia
1.8
6.8
124
778
R94.6
ICD-10 Finland
Abnormal results of thyroid function studies
17.0
6.8
10
6
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.8
6.6
34
129
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
6.5
156
1056
BAA20
NOMESCO Finland
Unilateral partial excision of thyroid gland
70.7
6.4
7
*
24210
ICD-8 Finland
Thyrotoxicosis with or without goitre, Toxic nodular goitre
70.7
6.4
7
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
6.4
195
1400
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
14.5
6.4
10
7
Z2221
NOMESCO Finland
Medical doctor
1.7
6.4
147
982
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.3
6.4
24
76
A02BC02
ATC
pantoprazole; systemic
1.6
6.4
350
2899
A48
ICPC
General and Unspecified, Clarification/discussion RFE/demand
2.5
6.3
40
169
E07.80
ICD-10 Finland
Pituitary thyroxin resistence
+∞
6.3
6
*
C73.92
ICD-10 Finland
Follicular carcinoma of the thyroid gland
+∞
6.3
6
*
JN5PN
NOMESCO Finland
Isotope imaging of secondary neoplasms of thyroid origin
+∞
6.3
6
*
2468X
ICD-9 Finland
Other disorders of thyroid, Other specified disorders of thyroid[MORBUS GLANDULAE THYREOIDEAE ALIUD]
+∞
6.3
6
*
6481B
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Thyroid dysfunction[HYPOTHYREOSIS IN GRAVIDITATE]
+∞
6.3
6
*
R07.0
ICD-10 Finland
Pain in throat
2.4
6.2
41
176
J01AA02
ATC
doxycycline; systemic
1.7
6.2
402
3463
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
6.1
129
842
K30
ICD-10 Finland
Functional dyspepsia
2.0
6.1
68
364
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.7
6.0
148
1004
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
128
145
11.41
108.05
4.2
1.4
4.84
4.44
pmol/l
2.24
122
131
72
48
17.27
83.51
2.6
1.3
2.71
1.34
iu/l
1.87
29
12
87
230
4.35
30.37
1.4
1.2
133.61
68.63
u/ml
0.82
30
83
457
3453
3.83
23.16
8.8
2.8
15.67
14.47
pmol/l
10.17
441
3139
333
2292
2.28
17.45
9.2
6.3
1.22
1.22
mmol/l
0.03
300
1990
41
94
4.65
16.92
1.2
1.2
—
—
—
0
0
87
372
2.61
13.47
2.3
2.0
369.14
366.20
nmol/l
0.05
81
348
292
2055
1.97
12.62
8.8
5.4
1.22
1.22
mmol/l
0.13
278
1894
479
4110
3.31
12.20
10.7
4.0
1.93
1.90
mu/l
0.07
460
3787
100
477
2.36
12.18
2.0
2.8
5.30
6.23
umol/l
0.54
89
410
182
1119
1.97
11.42
2.0
2.2
—
—
—
0
0
413
3378
2.12
10.54
5.2
4.4
11.93
12.42
mm/h
0.29
397
3140
295
2185
1.82
9.89
2.9
2.5
77.75
78.94
nmol/l
0.33
276
1971
75
354
2.31
9.25
2.5
3.0
68.20
81.78
ng/l
1.13
66
305
233
1643
1.76
8.92
3.1
3.4
2.35
2.37
mmol/l
1.96
219
1488
284
2140
1.73
8.42
2.8
2.7
—
—
estimate
—
0
0
120
709
1.90
8.10
2.3
3.0
2.88
2.99
e6/l
0.04
45
310
266
2018
1.66
7.29
4.8
4.3
36.67
35.79
g/l
2.13
253
1888
133
866
1.72
6.36
3.9
3.7
571.05
248.34
ng/l
0.25
94
651
78
431
1.95
6.35
2.6
2.2
35.26
35.74
u/l
0.03
68
353
402
3465
1.72
6.13
8.2
7.8
77.12
78.10
u/l
0.17
393
3277
483
4446
2.35
5.58
22.9
17.4
139.59
139.70
mmol/l
0.43
476
4347
476
4358
2.19
5.55
18.2
14.9
22.40
23.41
mg/l
0.28
400
3554
468
4259
2.06
5.53
5.8
5.0
5.87
5.85
mmol/l
0.13
445
3894
483
4450
2.34
5.50
23.3
17.5
3.95
3.95
mmol/l
0.04
476
4337
120
791
1.67
5.40
2.2
2.9
0.85
1.08
e6/l
0.47
45
386
257
2031
1.53
5.30
2.6
2.1
99.15
96.26
pmol/l
0.42
133
987
356
3039
1.55
4.99
5.2
5.0
6.00
3799.36
e6/l
—
5
42
113
758
1.63
4.71
1.7
1.7
1012.37
1227.01
nmol/l
1.39
94
552
180
1345
1.52
4.68
2.9
3.0
795.11
1098.17
ng/l
1.40
153
1143
28
116
2.49
4.63
2.6
3.9
3.20
1.78
index
0.53
15
58
270
2199
1.48
4.56
4.0
3.0
102.86
105.75
ug/l
0.06
250
2052
459
4216
1.80
4.31
18.4
14.8
80.93
80.63
ml/min/173m2
0.11
429
3895
488
4582
2.20
4.15
13.5
11.8
24.17
24.25
u/l
0.04
477
4445
173
1312
1.48
4.09
2.9
3.1
0.23
0.49
e6/l
1.98
109
946
448
4104
1.70
4.02
6.9
6.1
38.35
38.81
mmol/mol
0.66
432
3841
467
4330
1.83
3.98
5.2
4.9
4.71
4.74
mmol/l
0.24
445
4018
160
1200
1.48
3.98
2.2
2.2
2.54
2.90
mg/l
1.25
138
1033
309
2629
1.44
3.89
7.3
4.4
6.41
6.53
mmol/l
0.61
290
2477
286
2404
1.43
3.82
5.6
6.1
10.56
10.64
umol/l
0.06
272
2284
193
1514
1.44
3.77
3.1
3.2
37.37
106.33
e6/l
0.74
131
1151
133
976
1.49
3.65
3.2
2.7
2.44
2.46
mmol/l
1.32
119
873
119
855
1.51
3.61
1.6
1.5
—
—
—
0
0
145
1088
1.46
3.55
2.4
2.5
321.67
325.10
umol/l
0.16
120
970
305
2613
1.41
3.54
8.7
9.5
3.87
4.07
e9/l
0.88
266
2268
121
877
1.50
3.52
1.4
1.3
13.81
10.08
u/ml
0.19
45
323
470
4400
1.76
3.40
6.1
5.7
2.72
2.74
mmol/l
0.16
445
4076
463
4322
1.69
3.32
5.1
4.8
1.52
1.55
mmol/l
1.12
436
3997
401
3641
1.45
3.12
23.4
19.7
331.68
330.98
g/l
0.91
396
3619
11
30
3.72
3.10
1.1
1.3
—
—
—
0
0
18
76
2.42
2.92
1.7
1.6
—
—
—
0
0
25
122
2.10
2.92
1.3
1.2
—
—
—
0
0
175
1404
1.37
2.85
3.1
2.4
57.01
65.00
u/l
0.88
164
1297
134
1030
1.41
2.81
1.9
1.6
1.19
1.14
mg/l
0.07
99
815
19
84
2.31
2.80
5.0
2.8
8.41
7.76
pmol/l
0.12
19
84
494
4732
2.03
2.78
28.8
23.1
257.97
255.86
e9/l
0.32
486
4640
494
4733
2.03
2.76
28.8
23.1
4.45
4.42
e12/l
0.93
485
4624
46
281
1.70
2.75
1.6
1.7
—
—
—
0
0
57
372
1.60
2.65
1.4
1.5
—
—
—
0
0
24
120
2.05
2.65
1.6
1.9
187.50
199.77
%
0.33
24
113
16
69
2.36
2.50
1.4
1.3
0.41
27.64
nmol/l
0.50
16
63
330
2952
1.33
2.44
3.8
3.1
48.78
44.33
u/l
0.42
316
2769
174
1423
1.34
2.44
2.5
2.1
126.26
178.40
u/l
1.80
165
1359
141
1119
1.36
2.41
1.5
1.3
0.72
2.18
u/ml
1.72
27
299
11
39
2.86
2.35
1.1
1.1
—
—
—
0
0
15
65
2.35
2.33
1.5
1.8
—
—
—
0
0
23
120
1.96
2.29
1.3
1.3
—
9.71
—
0
10
303
2697
1.30
2.23
3.3
3.1
—
—
—
0
0
8
24
3.37
2.19
2.5
1.2
22.38
22.65
nmol/l
—
8
24
181
1509
1.31
2.18
3.3
3.0
27.19
29.07
u/l
0.82
171
1428
27
152
1.82
2.16
2.3
2.2
9.92
11.58
nmol/l
0.42
27
142
7
19
3.72
2.15
1.0
1.2
—
—
—
0
0
12
50
2.43
2.04
1.2
1.1
—
—
—
0
0
8
26
3.11
2.02
2.1
3.7
0.88
0.88
index
—
8
26
282
2507
1.28
2.01
4.0
4.2
0.00
9.03
estimate
1.07
55
544
27
156
1.77
2.00
1.3
1.3
—
18.01
—
0
9
98
768
1.34
1.80
1.7
1.9
—
—
—
0
0
13
60
2.20
1.79
1.2
1.0
0.72
2.03
eliau/ml
—
5
25
25
147
1.74
1.77
1.6
1.9
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
18
3.36
1.75
1.0
1.3
—
—
—
0
0
22
125
1.79
1.74
1.2
1.3
—
—
—
0
0
434
4110
1.35
1.74
4.3
4.1
1.25
1.24
mmol/l
0.11
403
3760
163
1375
1.27
1.73
1.7
1.7
20.62
21.56
nmol/l
0.36
142
1148
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
5
13
3.87
1.72
1.2
2.1
155.40
109.62
%
—
5
13
222
1947
1.25
1.68
2.0
1.9
1.31
1.33
mmol/l
0.10
192
1648
276
2480
1.24
1.67
3.9
4.1
0.00
0.00
estimate
0.50
53
532
14
69
2.06
1.66
1.5
1.3
—
—
—
0
0
118
961
1.30
1.65
1.5
1.3
17.00
31.34
iu/ml
1.51
33
287
280
2524
1.24
1.64
4.1
4.2
0.00
0.03
estimate
1.49
52
519
35
232
1.55
1.59
1.6
1.4
23.16
27.79
iu/l
0.41
29
201
11
51
2.18
1.51
1.3
1.2
—
31.83
—
0
6
25
155
1.64
1.49
1.6
2.0
—
—
—
0
0
66
502
1.36
1.48
16.9
6.4
1.28
1.25
mmol/l
0.02
56
416
19
113
1.71
1.33
1.4
1.3
479.79
513.33
mg/l
0.14
19
106
91
740
1.28
1.29
3.0
2.3
12.82
12.94
umol/l
0.06
86
682
5
18
2.79
1.29
1.4
1.6
110.00
66.06
nmol/24h
—
5
18
25
162
1.57
1.28
1.8
1.7
—
—
—
0
0
74
588
1.30
1.26
1.8
1.7
—
—
—
0
0
20
123
1.65
1.26
1.3
1.5
—
—
—
0
0
54
410
1.35
1.25
2.0
2.2
0.23
0.21
g/l
0.83
49
393
17
100
1.72
1.25
3.6
3.1
16.83
26.93
mg/l
0.91
11
65
36
494
0.71
1.20
6.1
6.7
—
—
—
0
0
20
125
1.62
1.19
1.3
1.5
0.83
1.30
ratio
—
9
74
20
125
1.62
1.19
1.3
1.5
1.27
1.10
ratio
—
8
74
20
125
1.62
1.19
1.3
1.5
1.06
0.95
ratio
—
8
74
21
133
1.60
1.19
1.6
1.4
258.31
312.97
ug/g
0.58
12
78
17
102
1.69
1.17
1.3
1.2
3.38
3.77
mmol/l
1.16
17
94
5
20
2.51
1.15
1.2
1.1
—
—
—
0
0
227
2054
1.19
1.15
15.0
12.7
1.27
1.20
inr
1.08
181
1677
70
560
1.29
1.14
1.9
1.8
—
—
—
0
0
70
563
1.28
1.10
4.5
4.7
32.23
32.78
%
0.19
56
361
5
21
2.39
1.09
1.0
1.6
—
—
—
0
0
40
298
1.37
1.06
1.6
2.0
—
—
—
0
0
14
82
1.73
1.06
1.4
1.4
—
—
—
0
0
14
82
1.73
1.06
1.4
1.4
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
16
98
1.65
1.04
1.9
2.4
0.40
0.39
iu/ml
—
7
59
9
46
1.97
1.04
1.0
1.1
—
—
—
0
0
5
22
2.28
1.03
1.8
2.4
—
—
—
0
0
5
22
2.28
1.03
1.2
4.2
1006.20
810.41
u/ml
—
5
22
7
34
2.07
1.03
1.1
1.1
—
—
—
0
0
79
651
1.25
1.03
3.2
2.3
20.73
22.86
%
0.79
73
610
64
515
1.28
1.01
3.2
4.0
49.35
17.74
ug/l
0.29
51
423
7
35
2.01
1.00
1.0
1.1
—
—
—
0
0
5
23
2.19
0.98
1.2
1.2
—
—
—
0
0
7
36
1.96
0.97
1.0
1.1
—
—
—
0
0
44
339
1.33
0.96
1.5
1.5
—
—
—
0
0
7
37
1.90
0.94
1.0
1.1
—
—
—
0
0
7
37
1.90
0.94
1.0
1.1
—
—
—
0
0
20
134
1.51
0.93
1.4
1.6
63.44
57.73
ug/l
0.20
14
107
19
126
1.53
0.92
1.8
2.5
—
—
—
0
0
25
177
1.43
0.90
1.9
2.4
3708.58
5726.61
u/l
—
10
77
8
45
1.79
0.84
1.7
1.1
112.88
110.87
pmol/l
—
8
45
121
1368
0.85
0.84
4.5
4.2
0.00
0.01
estimate
0.74
45
500
83
705
1.21
0.83
3.1
2.2
2.45
2.34
g/l
1.00
77
649
8
46
1.75
0.83
1.8
1.1
—
—
—
0
0
0
24
0.00
0.79
0.0
1.1
—
—
—
0
0
0
24
0.00
0.79
0.0
1.1
—
—
—
0
0
0
25
0.00
0.79
0.0
1.6
—
—
—
0
0
21
148
1.44
0.79
1.3
1.3
275.99
264.72
miu/ml
0.06
12
79
13
82
1.60
0.78
1.4
1.7
—
—
—
0
0
55
452
1.24
0.76
1.8
2.1
—
—
—
0
0
10
59
1.71
0.76
1.2
1.1
—
—
—
0
0
18
124
1.47
0.76
7.5
2.0
3.29
3.69
g/l
0.81
18
117
5
25
2.01
0.73
1.2
1.9
—
—
—
0
0
10
60
1.68
0.72
1.2
1.5
—
—
—
0
0
7
40
1.76
0.71
1.0
1.1
—
—
—
0
0
13
85
1.54
0.69
1.2
1.2
—
—
—
0
0
10
63
1.60
0.62
3.4
3.8
—
—
—
0
0
5
30
1.67
0.61
1.8
1.3
51.40
73.87
ng/l
—
5
30
20
148
1.37
0.60
1.5
1.5
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
6
35
1.72
0.58
2.2
2.2
—
—
—
0
0
30
240
1.27
0.55
1.4
1.9
—
—
—
0
0
16
116
1.39
0.55
1.9
2.1
118.70
124.97
g/l
—
10
89
18
135
1.35
0.51
2.6
2.7
22.79
25.44
mmol/l
1.02
18
135
18
135
1.35
0.51
1.5
1.1
1.67
1.60
g/l
0.68
18
135
104
941
1.13
0.51
1.8
1.7
500.31
15709256.65
pmol/l
0.78
88
783
57
494
1.17
0.50
2.0
2.3
—
—
—
0
0
30
244
1.24
0.49
3.1
2.5
1.15
1.17
%
0.02
30
244
15
110
1.37
0.49
1.4
1.4
—
—
—
0
0
24
190
1.28
0.49
3.0
3.0
28.05
1227.67
u/ml
0.93
19
160
31
254
1.23
0.48
3.6
3.3
5.03
5.19
kpa
0.34
31
245
16
121
1.33
0.44
1.3
1.5
—
—
—
0
0
14
104
1.36
0.43
3.2
2.7
8.62
7.93
kpa
0.70
14
104
6
91
0.66
0.42
1.3
1.2
—
200.00
—
0
9
18
140
1.30
0.42
1.5
1.2
0.80
0.92
g/l
1.50
18
140
5
32
1.57
0.42
1.2
1.2
—
—
—
0
0
5
32
1.57
0.42
1.2
1.2
—
—
—
0
0
177
1875
0.91
0.41
4.3
4.0
0.08
0.03
estimate
0.23
39
439
0
15
0.00
0.41
0.0
1.8
—
—
—
0
0
0
15
0.00
0.41
0.0
1.8
—
—
—
0
0
0
15
0.00
0.41
0.0
1.8
—
—
—
0
0
5
34
1.48
0.40
1.0
1.1
—
6.72
—
0
13
8
60
1.34
0.40
3.6
2.5
1.18
1.19
mmol/l
—
8
60
8
61
1.32
0.39
3.6
2.4
105.13
106.59
mmol/l
—
8
61
8
61
1.32
0.39
1.0
1.2
—
—
—
0
0
5
35
1.43
0.39
1.0
1.0
—
—
—
0
0
16
125
1.29
0.37
1.3
1.5
—
—
—
0
0
5
77
0.65
0.36
1.6
1.4
—
—
—
0
0
5
80
0.62
0.35
4.2
4.0
—
305.00
—
0
8
5
80
0.62
0.35
1.0
1.6
—
—
—
0
0
116
1081
1.09
0.35
4.0
4.2
1.02
2.43
kg/l
0.50
77
715
6
90
0.66
0.33
1.3
1.2
—
—
—
0
0
16
128
1.26
0.32
3.6
3.5
24.40
24.73
mmol/l
0.31
16
119
15
119
1.27
0.32
1.5
1.4
—
—
—
0
0
8
106
0.75
0.29
1.5
1.6
—
—
—
0
0
113
1063
1.08
0.28
2.8
2.5
6.76
6.26
e6/l
0.12
100
968
8
62
1.29
0.28
1.0
1.2
—
—
—
0
0
8
62
1.29
0.28
1.0
1.2
—
—
—
0
0
8
64
1.25
0.27
1.0
1.2
—
—
—
0
0
8
64
1.25
0.27
1.0
1.2
—
—
—
0
0
8
64
1.25
0.27
1.0
1.2
—
—
—
0
0
25
215
1.17
0.27
3.1
3.2
0.79
2.21
mmol/l
1.35
18
161
12
96
1.26
0.24
1.2
1.4
—
—
—
0
0
158
1513
1.06
0.24
3.6
3.2
7.89
6.91
mmol/l
1.58
139
1280
41
373
1.11
0.21
6.7
3.7
1.24
1.23
mmol/l
0.34
36
324
0
12
0.00
0.21
0.0
1.0
—
46.76
—
0
12
139
1333
1.06
0.21
3.9
3.5
0.00
0.01
estimate
0.74
37
427
6
48
1.25
0.20
1.0
1.3
7.77
6.90
mmol/l
—
6
39
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
9
115
0.78
0.20
1.3
1.7
—
—
—
0
0
17
146
1.17
0.19
1.1
1.3
—
—
—
0
0
101
962
1.06
0.19
1.4
1.5
—
—
—
0
0
17
147
1.16
0.18
1.1
1.1
—
—
—
0
0
7
62
1.13
0.17
1.0
1.0
—
—
—
0
0
34
311
1.10
0.17
3.6
3.3
0.56
0.77
ug/l
1.21
24
219
11
92
1.20
0.16
1.2
1.4
—
—
—
0
0
47
439
1.08
0.15
3.9
3.2
—
—
—
0
0
22
244
0.90
0.15
1.2
1.4
—
—
—
0
0
7
88
0.79
0.14
2.6
2.4
14.00
15.81
%
—
7
88
33
307
1.08
0.12
3.8
2.7
128.88
126.46
g/l
0.31
33
298
25
230
1.09
0.11
1.4
1.6
683.11
993.59
mu/l
1.33
17
184
38
357
1.07
0.11
2.4
2.6
68.42
68.15
ml/min/173m2
0.02
24
145
25
231
1.09
0.11
1.6
1.5
—
—
—
0
0
5
48
1.04
0.09
1.2
1.3
—
—
—
0
0
46
440
1.05
0.08
4.5
2.9
1.42
1.94
mmol/l
0.54
41
371
34
322
1.06
0.08
1.8
1.8
3.50
3.45
mmol/l
0.07
23
232
6
71
0.84
0.07
1.0
1.3
—
—
—
0
0
16
148
1.08
0.06
1.1
1.1
—
—
—
0
0
16
172
0.93
0.06
1.3
1.4
—
—
—
0
0
19
178
1.07
0.05
1.8
1.4
0.21
0.34
mg/l
—
6
72
26
247
1.06
0.05
4.3
2.8
24.01
24.30
mmol/l
0.25
26
241
16
150
1.07
0.04
1.5
3.2
0.98
5.19
ratio
—
6
80
13
139
0.93
0.03
1.3
1.2
—
—
—
0
0
42
430
0.97
0.02
1.8
2.0
3.54
3.36
ratio
0.30
33
341
55
540
1.02
0.02
6.7
5.4
8.62
2.64
ug/l
0.43
50
470
168
1668
1.01
0.02
4.4
3.7
35.68
55.30
ng/l
0.39
122
1174
26
252
1.03
0.02
1.0
1.0
—
—
—
0
0
23
224
1.03
0.00
1.3
1.5
—
—
—
0
0
13
125
1.04
0.00
1.2
1.4
—
—
—
0
0
15
154
0.97
0.00
1.9
1.9
—
—
—
0
0
16
156
1.03
0.00
2.2
1.6
144.75
237.52
ug/l
0.99
16
143
147
1473
1.00
0.00
4.3
3.9
12.10
8.22
mg/mmol
0.23
93
873
0
8
0.00
0.00
0.0
3.0
—
60.34
—
0
8
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
7.1
—
5.61
—
0
7
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
1.20
—
0
7
42
420
1.00
-0.00
4.6
4.6
20.08
22.06
%
0.25
18
224
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.01
—
0
6
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
6.02
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
7.0
—
9.70
—
0
7
0
6
0.00
-0.00
0.0
5.5
—
—
—
0
0
6
68
0.88
-0.00
5.8
4.4
43.67
67.37
u/ml
—
6
68
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
-0.00
1.6
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYROIDNASOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROIDNASOTH | 1.444 [1.16, 1.8] | 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.115 |
During the follow-up period (1.1.1998 — 31.12.2019), 162 out of 1145 females with E4_THYROIDNASOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROIDNASOTH | 0.919 [0.68, 1.25] | 0.585 |
| Birth year | 0.988 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 66 out of 391 males with E4_THYROIDNASOTH died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYROIDNASOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.15% | 0.156% |
| 5 | 0.893% | 1.064% |
| 10 | 2.105% | 2.826% |
| 15 | 3.935% | 5.346% |
| 20 | 6.989% | 8.95% |
Relationships between endpoints
↥Index endpoint: E4_THYROIDNASOTH – Disorder of thyroid, unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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