HSIL lesion of the vulva

N14_VULVAL_HSIL

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

only females

313377

2. Check conditions

None

313377

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D07.1&, N90.1, N90.2
  • Hospital discharge: ICD-9 2333B
  • Cause of death: ICD-10 D07.1&, N90.1, N90.2
  • Cause of death: ICD-9 2333B

2 out of 7 registries used, show all original rules.

735

4. Check minimum number of events

None

735

5. Include endpoints

None

735

6. Filter based on genotype QC (FinnGen only)

648

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF7

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2936 2936 -
Only index persons 2789 2789 -
Unadjusted period prevalence (%)
Whole population 0.08 0.08 -
Only index persons 0.10 0.10 -
Median age at first event (years)
Whole population - 55.85 -
Only index persons - 55.25 -

-FinnGen-

Key figures

All Female Male
Number of individuals 648 648 -
Unadjusted period prevalence (%) 0.23 0.23 -
Median age at first event (years) 57.25 57.25 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
675
Matched controls
6750
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N90.1
ICD-10 Finland
Moderate vulvar dysplasia
+∞
320.1
281
*
N90.2
ICD-10 Finland
Severe vulvar dysplasia, not elsewhere classified
+∞
307.7
394
*
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
101.9
307.7
435
118
LFB10
NOMESCO Finland
Excision of lesion of vulva or perineum
166.6
307.7
245
23
ULA02
NOMESCO Finland
Kolposcopy
48.7
307.7
545
535
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
13.3
265.1
407
693
LFB20
NOMESCO Finland
Destruction of lesion of vulva or perineum
116.6
242.6
124
13
LEB00
NOMESCO Finland
Biopsy of vagina
31.1
240.2
166
70
8077/2-C51.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vulva, NOS
1495.5
226.6
208
*
N90.0
ICD-10 Finland
Mild vulvar dysplasia
106.4
178.1
92
10
D06BB10
ATC
imiquimod; topical
12.6
166.5
188
201
D07.1
ICD-10 Finland
Carcinoma in situ: Vulva
+∞
148.6
137
*
LFC00
NOMESCO Finland
Partial excision of vulva
587.8
147.5
141
*
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
9.0
140.2
211
324
A63.0
ICD-10 Finland
Anogenital (venereal) warts
14.0
132.3
132
115
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
6.9
119.5
246
521
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
9.1
93.6
127
168
N76.6
ICD-10 Finland
Ulceration of vulva
23.9
88.8
65
30
LEB30
NOMESCO Finland
Destruction of lesion of vaginal mucosa
29.0
82.5
56
21
N89.1
ICD-10 Finland
Moderate vaginal dysplasia
50.4
80.7
47
10
R87.5
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal microbiological findings
12.5
69.3
71
63
LDA10
NOMESCO Finland
Curettage of cervix uteri
6.9
69.3
119
203
N87.0
ICD-10 Finland
Mild cervical dysplasia
9.4
68.3
87
105
D07AD01
ATC
clobetasol; topical
4.2
66.0
251
840
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
7.1
63.5
104
168
N89.0
ICD-10 Finland
Mild vaginal dysplasia
29.8
62.6
42
15
N90.8
ICD-10 Finland
Other specified noninflammatory disorders of vulva and perineum
14.2
57.7
54
41
N90.4
ICD-10 Finland
Leukoplakia of vulva
23.5
57.4
42
19
N90.9
ICD-10 Finland
Noninflammatory disorder of vulva and perineum, unspecified
22.3
56.3
42
20
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
3.4
52.8
391
1954
N87.1
ICD-10 Finland
Moderate cervical dysplasia
8.8
50.3
66
82
C51.01
ICD-10 Finland
Squamous cell carcinoma of the labium majus
467.1
44.8
44
*
8077/2-C52.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vagina, NOS
234.9
43.4
44
*
D06BB04
ATC
podophyllotoxin; topical
5.7
43.2
87
171
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
7.8
41.7
60
83
C51.11
ICD-10 Finland
Squamous cell carcinoma of the labium minus
141.5
38.1
40
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.6
36.3
142
465
8071/2-C51.9
ICD-O-3
Differentiated intraepithelial neoplasia of vulva, NOS
+∞
35.7
34
*
8070/3-C51.9
ICD-O-3
Squamous cell carcinoma, NOS, of vulva, NOS
365.3
35.3
35
*
TLW99
NOMESCO Finland
Other minor surgical procedure in gynaecology
6.8
35.1
57
90
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
3.1
31.6
163
629
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
8.1
28.3
39
51
N89.2
ICD-10 Finland
Severe vaginal dysplasia, not elsewhere classified
47.8
26.7
32
7
Y83.8
ICD-10 Finland
Other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
5.7
25.3
49
92
L04AA06
ATC
mycophenolic acid; systemic
8.1
23.6
32
41
J02AC01
ATC
fluconazole; systemic
2.3
23.1
409
2730
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
3.1
22.9
108
391
B01AB10
ATC
tinzaparin; parenteral
2.8
22.1
125
500
ZXC10
NOMESCO Finland
Use of laser
6.2
21.1
37
63
N90.3
ICD-10 Finland
Dysplasia of vulva, unspecified
113.6
20.7
22
*
G01AA10
ATC
clindamycin; vaginal
2.4
20.5
190
961
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
4.2
20.5
57
145
8070/2-C51.9
ICD-O-3
Squamous cell carcinoma in situ, NOS, of vulva, NOS
+∞
19.9
19
*
C51.81
ICD-10 Finland
Squamous cell carcinoma of the vulva
72.0
18.8
21
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
8.1
18.4
25
32
WX002
NOMESCO Finland
Sedation and analgesia
2.3
18.2
173
879
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.7
18.2
43
96
P01AB01
ATC
metronidazole; oral, rectal
2.0
18.2
367
2487
T81.3
ICD-10 Finland
Disruption of operation wound, not elsewhere classified
5.4
15.9
32
62
LDB20
NOMESCO Finland
Electrocoagulation or laser therapy of cervix uteri
7.4
15.8
23
32
LFD10
NOMESCO Finland
Vulvectomy and excision of regional lymph nodes
+∞
15.7
15
*
ZZR00
NOMESCO Finland
Flap of skin
5.8
15.2
28
50
L29.2
ICD-10 Finland
Pruritus vulvae
4.7
15.1
35
77
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
7.0
14.9
23
34
N94.1
ICD-10 Finland
Dyspareunia
7.0
14.9
23
34
WX320
NOMESCO Finland
Spinalanesthesy
2.0
14.8
211
1243
8070/3-C51.1
ICD-O-3
Squamous cell carcinoma, NOS, of labium minus
+∞
14.6
14
*
UKC02
NOMESCO Finland
Cystoscopy
2.5
14.6
97
417
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
14.1
171
948
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
2.0
13.4
492
3903
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.6
13.1
81
336
E0000UV, ,
ATC
1.8
12.7
332
2353
8077/2-C51.1
ICD-O-3
Squamous intraepithelial neoplasia, high grade of labium minus
+∞
12.5
12
*
2333B
ICD-9 Finland
Carcinoma in situ of breast and genito-urinary system, Other and unspecified female genital organs[CARCINOMA IN SITU VULVAE]
+∞
12.5
12
*
8474
FHL
Coagulation, excision, or biopsy of local change (eg, condyloma, tumor) in operating room or anesthesia
20.5
12.5
18
9
WZC00
NOMESCO Finland
Treatment plan or consultation
1.8
12.3
286
1952
LCA06
NOMESCO Finland
Biopsy of endometrium
2.0
11.8
142
779
J01MA02
ATC
ciprofloxacin; systemic
1.8
11.8
270
1829
JN2DG
NOMESCO Finland
Very extensive MRI examination of lower part of abdoment with high intensity magnet
5.7
11.7
22
40
D07AC01
ATC
betamethasone; topical
1.8
11.6
274
1870
D07AB02
ATC
hydrocortisone butyrate; topical
1.8
11.5
240
1577
LFC96
NOMESCO Finland
Other partial excision of vulva or perineum
122.0
11.5
12
*
127
Kela drug reimbursment
Transplant complication
9.1
11.3
23
26
PJD55
NOMESCO Finland
Block dissection of inguinal lymph nodes
35.7
11.3
14
*
C51.9
ICD-10 Finland
Malignant neoplasm: Vulva, unspecified
35.7
11.3
14
*
LFE10
NOMESCO Finland
Plastic repair of vulva
17.4
11.2
17
10
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
11.2
331
2400
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.3
11.0
89
417
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
11.0
191
1185
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
10.9
101
500
X16
ICPC
Vulval symptom/complaint
4.4
10.9
27
63
A11CC03
ATC
alfacalcidol; systemic
4.8
10.8
24
51
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
4.8
10.8
24
51
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.9
10.6
174
1059
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.1
10.5
116
616
LFD00
NOMESCO Finland
Vulvectomy
111.7
10.4
11
*
8542/3-C51.9
ICD-O-3
Paget disease, extramammary of vulva, NOS
111.7
10.4
11
*
WF002
NOMESCO Finland
Radical radiotherapy
3.6
10.3
34
98
TQW80
NOMESCO Finland
Local dermatologic skincare
4.4
10.1
25
58
B03XA02
ATC
darbepoetin alfa; parenteral
4.9
10.1
22
46
ZXC00
NOMESCO Finland
Use of diathermy
10.3
10.1
19
19
B01AB05
ATC
enoxaparin; parenteral
1.7
10.1
239
1619
TLC02
NOMESCO Finland
Simple extraction of IUD
2.9
10.0
49
180
L04AX01
ATC
azathioprine; systemic
3.2
9.8
38
122
J01EA01
ATC
trimethoprim; systemic
1.7
9.8
242
1656
R50.9
ICD-10 Finland
Fever, unspecified
2.0
9.7
110
588
R03AC02
ATC
salbutamol; inhalant
1.7
9.6
419
3325
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.7
9.5
53
208
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
101.4
9.4
10
*
PJ5AQ
NOMESCO Finland
Sentinell lymphnode SPECT with low dose CT
17.8
9.4
14
8
WX402
NOMESCO Finland
General anaesthesia
1.8
9.4
170
1061
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.5
9.3
59
247
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.8
9.1
178
1134
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
4.9
9.1
20
42
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
9.1
92
471
N02AX02
ATC
tramadol; systemic, rectal
1.6
9.0
297
2179
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.3
9.0
74
349
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
8.9
283
2055
D05BB02
ATC
acitretin; oral
4.6
8.9
21
47
L57.0
ICD-10 Finland
Actinic keratosis
2.1
8.9
86
433
J01AA02
ATC
doxycycline; systemic
1.9
8.8
553
4786
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
8.7
204
1367
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
3.6
8.6
28
80
128
Kela drug reimbursment
Cancers of female genital organs
3.6
8.6
28
80
ZXE00
NOMESCO Finland
One hour or less
1.6
8.6
285
2088
LFW96
NOMESCO Finland
Other operation on vulva or perineum
27.9
8.5
11
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.8
8.5
164
1041
Z94.0
ICD-10 Finland
Kidney transplant status
9.6
8.3
16
17
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
14.7
8.2
13
9
A12AA04
ATC
calcium carbonate; oral
8.3
8.1
17
21
G01AF01
ATC
metronidazole; vaginal
1.9
8.0
106
598
KA1AE
NOMESCO Finland
Kidney ultrasound examination
4.5
7.9
19
43
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
7.9
7.9
17
22
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.0
7.9
97
533
C03CA01
ATC
furosemide; systemic
1.7
7.8
187
1254
A02BC02
ATC
pantoprazole; systemic
1.6
7.8
480
4042
R06.0
ICD-10 Finland
Dyspnoea
1.7
7.8
197
1340
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.0
7.8
90
484
X15
ICPC
Vaginal symptom/complaint other
2.6
7.7
46
187
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.7
7.7
181
1207
C51.00
ICD-10 Finland
Malignant tumor of the labium majus without histology
45.5
7.7
9
*
N76.3
ICD-10 Finland
Subacute and chronic vulvitis
4.4
7.7
19
44
E000001, ,
ATC
1.7
7.7
148
936
UJF32
NOMESCO Finland
Coloscopy
1.7
7.7
184
1235
LWA00
NOMESCO Finland
Repair of wound dehiscence in gynaecological surgery
18.6
7.6
11
6
J05AB01
ATC
aciclovir; systemic
1.7
7.6
184
1237
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
3.1
7.6
32
108
R2110
NOMESCO Finland
Giving the first information
2.2
7.6
63
298
J01FF01
ATC
clindamycin; systemic
1.7
7.5
189
1285
N02BE01
ATC
paracetamol; systemic, rectal
2.3
7.4
625
5715
L04AA01
ATC
[U] ciclosporin
6.1
7.4
19
32
Z3231
NOMESCO Finland
Registered nurse
1.7
7.4
188
1278
R87.7
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal histological findings
13.5
7.4
12
9
J01DB01
ATC
cefalexin; oral
1.8
7.4
570
5054
L43.8
ICD-10 Finland
Other lichen planus
3.7
7.4
23
64
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.1
7.4
74
378
LEB10
NOMESCO Finland
Excision of lesion of vagina
9.5
7.3
14
15
8077/2-C51.8
ICD-O-3
Squamous intraepithelial neoplasia, high grade of overlapping lesion of vulva
+∞
7.3
7
*
XX1AT
NOMESCO Finland
Other puncture with ultrasound guidance
5.9
7.3
19
33
JN3AD
NOMESCO Finland
Abdominal CT examination
1.9
7.2
93
518
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
7.2
291
2206
T89
ICPC
Diabetes insulin dependent
2.9
7.2
33
117
WZC30
NOMESCO Finland
Teaching
1.8
7.1
118
712
D28.0
ICD-10 Finland
Benign neoplasm: Vulva
8.0
7.1
15
19
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.8
7.1
108
636
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.7
7.1
38
147
G04BD12
ATC
mirabegron; oral
1.9
7.0
93
523
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.6
7.0
39
154
GD1AD
NOMESCO Finland
Thorax CT examination
2.4
7.0
46
197
M79.6
ICD-10 Finland
Pain in limb
1.5
6.9
338
2665
TQW40
NOMESCO Finland
Remowal of suture of skin
2.2
6.9
57
269
WX892
NOMESCO Finland
Monitored bed care
2.3
6.8
49
218
LFE96
NOMESCO Finland
Other repair of vulva or perineum
40.5
6.8
8
*
A63.8
ICD-10 Finland
Other specified predominantly sexually transmitted diseases
16.9
6.8
10
6
Z2221
NOMESCO Finland
Medical doctor
1.6
6.7
201
1418
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
22.8
6.7
9
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
6.7
104
616
SPAT1153
SPAT
Removal of sutures
1.6
6.6
213
1528
R42
ICD-10 Finland
Dizziness and giddiness
1.6
6.6
173
1181
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
3.3
6.6
24
74
0781C
ICD-9 Finland
Other diseases due to viruses and Chlamydiae, Viral warts[CONDYLOMA ACCUMINATUM]
10.2
6.6
12
12
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.9
6.5
92
528
Z01.2
ICD-10 Finland
Dental examination
1.5
6.5
333
2641
WX702
NOMESCO Finland
Supraglottic ventilation device
2.3
6.5
51
236
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.1
6.5
59
290
7020X
ICD-9 Finland
Other dermatoses, Actinic keratosis[DERMATOSES PRAECANCEROSAE ALIAE]
70.5
6.4
7
*
PJD45
NOMESCO Finland
Excision of inguinal lymph nodes
14.5
6.4
10
7
L04AD01
ATC
ciclosporin; systemic
4.1
6.4
17
42
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
6.3
261
1974
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
2.4
6.3
44
193
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.9
6.2
87
498
ULC02
NOMESCO Finland
Hysteroscopy
2.1
6.2
55
268
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.3
6.1
44
196
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.8
6.1
29
105
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
8.7
6.1
12
14
137
Kela drug reimbursment
Uraemia requiring dialysis
10.1
6.0
11
11
ZXE10
NOMESCO Finland
More than one and less than three hours
1.5
6.0
248
1871
WF003
NOMESCO Finland
Adjuvant radiotherapy
2.8
6.0
29
106

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
197
136
20.04
229.87
3.8
1.8
—
—
—
0
0
50
13
41.46
81.98
1.9
2.2
6.34
2.20
ug/l
—
36
6
192
554
4.45
61.22
1.6
1.4
—
—
—
0
0
496
2737
4.06
59.81
5.0
2.1
—
—
—
0
0
196
850
2.84
30.65
1.5
1.3
—
—
—
0
0
444
2984
2.43
25.89
3.6
2.6
—
—
estimate
—
0
0
329
2059
2.17
21.22
3.0
2.1
—
—
—
0
0
264
1547
2.16
19.83
2.8
2.1
—
—
—
0
0
146
690
2.42
18.16
2.4
1.6
—
—
—
0
0
445
3313
2.01
16.00
6.8
5.8
9.08
10.03
umol/l
2.43
424
3151
392
2795
1.96
15.98
6.9
4.2
36.03
36.03
g/l
0.00
380
2631
575
4804
2.33
13.95
10.9
7.6
79.12
77.33
u/l
0.52
554
4552
158
859
2.10
13.65
2.6
1.9
—
—
—
0
0
364
2644
1.82
12.88
16.0
12.6
1.17
1.18
inr
0.08
309
2171
74
304
2.61
12.18
1.4
1.2
—
—
—
0
0
461
3655
1.82
11.62
12.1
9.0
4.01
3.96
e9/l
0.22
411
3199
442
3461
1.80
11.62
5.4
4.1
0.00
0.01
estimate
1.23
96
688
284
1960
1.78
11.56
4.9
3.2
19.02
55.17
e6/l
2.45
230
1478
325
2333
1.76
11.52
5.7
3.9
39.75
85.15
e6/l
2.56
248
1566
318
2269
1.76
11.51
3.9
3.2
—
—
—
0
0
238
1565
1.80
11.37
5.2
3.5
98.83
95.25
%
1.47
232
1525
419
3244
1.77
11.30
8.9
6.1
1.22
1.22
mmol/l
0.56
361
2785
170
1008
1.92
11.27
3.6
2.8
0.79
0.81
mmol/l
2.32
161
947
418
3244
1.76
11.07
9.3
5.9
0.55
0.55
e9/l
0.28
374
2804
293
2061
1.75
11.01
5.1
3.2
6.29
6.66
mmol/l
0.92
247
1745
447
3548
1.77
10.82
6.4
4.4
6.60
6.51
mmol/l
0.35
426
3338
423
3312
1.74
10.67
9.3
5.9
1.88
1.93
e9/l
0.45
393
2923
250
1694
1.76
10.63
5.0
3.1
0.25
0.43
e6/l
1.72
195
1220
227
1501
1.77
10.48
5.1
3.8
—
—
—
0
0
209
1349
1.80
10.47
3.7
2.6
9.25
8.00
e6/l
0.24
193
1242
429
3382
1.74
10.46
9.3
6.2
0.18
0.18
e9/l
0.16
395
2959
416
3255
1.72
10.39
9.4
6.0
0.04
0.04
e9/l
0.72
371
2809
93
455
2.21
10.36
9.1
6.6
—
—
—
0
0
283
2000
1.71
10.26
4.1
2.4
56.69
62.19
u/l
0.64
265
1849
379
2900
1.70
10.20
7.8
5.5
1.22
1.22
mmol/l
0.02
349
2670
428
3401
1.71
9.85
5.2
4.1
0.00
0.00
estimate
0.50
95
694
391
3045
1.68
9.60
9.4
6.0
27.84
28.62
%
0.75
373
2880
293
2119
1.68
9.56
8.8
5.8
—
—
—
0
0
385
2999
1.66
9.33
9.1
5.9
58.06
56.95
%
1.06
368
2849
362
2779
1.65
9.27
4.4
3.6
6.36
6.27
ph
0.72
201
1553
249
1744
1.68
9.06
2.9
3.1
1301.41
964.15
ng/l
0.31
210
1490
123
700
1.93
9.06
2.8
2.2
5.97
6.14
umol/l
0.05
106
607
179
1149
1.76
8.94
4.1
2.8
482.17
489.51
mosm/kgh2o
0.19
162
1019
427
3441
1.66
8.84
5.3
4.1
19.56
2.27
estimate
0.42
96
716
116
653
1.94
8.81
2.8
2.1
370.11
374.87
nmol/l
0.08
106
613
382
2995
1.63
8.81
9.7
6.1
8.47
8.51
%
0.11
358
2796
270
1942
1.65
8.81
4.9
3.3
55.97
31.60
mg/l
0.86
176
1142
657
6108
3.84
8.40
26.4
16.8
139.47
139.68
mmol/l
1.29
650
5979
657
6113
3.80
8.29
26.8
16.9
3.93
3.93
mmol/l
0.29
651
5969
378
2989
1.60
8.15
9.8
6.1
0.63
0.71
%
2.28
353
2774
270
1975
1.61
8.05
5.6
4.0
10.78
6.54
mg/mmol
0.63
167
1130
275
2021
1.61
8.04
5.3
3.7
7.40
7.40
ph
0.08
207
1455
209
1439
1.66
7.92
1.6
1.5
2.08
2.22
g/l
0.64
122
863
108
615
1.90
7.89
2.6
2.8
1.83
1.90
%
0.34
94
555
125
747
1.83
7.85
10.2
4.1
1.07
1.04
mmol/l
0.61
115
677
376
2991
1.58
7.74
9.7
6.0
2.72
2.77
%
0.18
354
2787
87
463
2.01
7.73
2.3
2.8
71.50
74.83
e9/l
0.39
69
338
161
1043
1.71
7.65
4.3
2.8
2.11
1.17
e6/l
0.69
96
518
117
691
1.84
7.62
1.8
1.4
—
—
—
0
0
106
615
1.86
7.29
6.7
6.4
-0.19
1.10
mmol/l
2.22
85
513
214
1512
1.61
7.20
1.9
1.7
0.92
1.04
mg/l
0.45
173
1172
105
619
1.82
6.85
6.8
6.5
7.41
7.42
ph
0.17
57
355
94
540
1.86
6.66
4.9
2.8
1.49
2.17
mmol/l
0.99
81
471
88
497
1.89
6.57
4.5
3.3
10.34
10.28
g/l
0.05
81
464
64
324
2.08
6.52
5.1
1.8
16.74
6.86
iu/ml
0.81
18
75
251
1874
1.54
6.51
5.1
4.2
0.00
0.00
estimate
0.80
91
675
643
6003
2.50
6.35
24.8
14.6
21.46
21.21
mg/l
0.07
558
4909
95
558
1.82
6.26
4.9
2.8
7.38
7.38
ph
0.01
67
310
65
338
2.02
6.16
5.4
3.4
7.42
7.42
ph
0.15
49
286
655
6179
3.03
6.14
20.4
13.2
—
—
—
0
0
141
938
1.64
5.93
4.5
3.0
3.25
4.45
e6/l
0.95
74
408
320
2558
1.48
5.79
4.9
4.0
0.04
0.04
estimate
0.06
80
569
31
122
2.62
5.62
1.2
1.1
—
—
—
0
0
48
233
2.14
5.47
1.7
2.2
1.74
1.51
g/l
0.79
41
209
246
1883
1.48
5.45
4.0
3.2
0.67
0.00
—
6
35
36
156
2.38
5.35
3.1
2.8
1.40
2.13
index
0.46
20
72
251
1938
1.47
5.29
2.5
2.1
112.46
179.11
u/l
1.26
236
1843
252
1954
1.46
5.17
7.1
6.0
—
—
—
0
0
382
3205
1.44
5.12
2.9
2.5
80.60
79.17
nmol/l
0.43
344
2915
349
2880
1.44
5.12
2.5
2.1
99.26
99.00
pmol/l
0.03
183
1436
149
1041
1.55
5.04
1.7
1.7
1172.01
1226.02
nmol/l
0.30
118
781
485
4265
1.49
5.03
4.9
3.9
—
0.14
—
0
7
52
272
1.99
4.88
2.2
2.0
1518.20
4743.58
u/l
1.08
21
117
11
17
6.56
4.79
1.2
1.4
—
—
—
0
0
573
5242
1.62
4.76
5.7
5.1
14.74
14.71
pmol/l
0.12
542
4873
37
173
2.20
4.65
1.3
1.2
—
—
—
0
0
126
866
1.56
4.56
4.3
2.3
21.02
21.52
%
0.19
111
809
39
188
2.14
4.55
3.9
1.3
—
—
—
0
0
145
1030
1.52
4.51
1.5
1.3
671.58
563.79
titre
0.23
38
243
113
761
1.58
4.46
1.5
1.3
—
—
—
0
0
77
470
1.72
4.45
1.5
1.3
—
—
—
0
0
41
204
2.08
4.42
3.8
1.3
—
—
—
0
0
116
788
1.57
4.41
1.6
1.3
—
—
—
0
0
67
397
1.76
4.30
2.0
1.8
1.29
1.38
g/l
0.18
59
366
41
207
2.04
4.26
3.8
1.3
—
—
—
0
0
218
1694
1.42
4.26
3.0
2.3
2.92
2.89
mg/l
0.07
184
1453
466
4121
1.42
4.25
4.2
3.1
49.89
41.61
u/l
1.06
445
3877
134
948
1.52
4.24
4.0
2.3
2.25
2.40
g/l
2.63
119
881
143
1026
1.50
4.23
1.9
1.6
—
—
—
0
0
333
2785
1.39
4.22
14.9
10.7
0.00
0.00
e9/l
0.97
282
2284
196
1498
1.43
4.18
2.9
2.4
313.99
312.48
umol/l
0.07
175
1324
31
142
2.24
4.11
3.1
1.6
—
—
—
0
0
237
1879
1.40
4.10
1.8
1.7
21.61
21.21
nmol/l
0.14
209
1594
70
426
1.72
4.10
2.0
2.3
2.47
5.39
ug/l
3.65
58
377
136
974
1.50
4.05
1.2
1.2
—
—
—
0
0
624
5884
1.80
4.03
7.3
6.2
1.83
1.85
mu/l
0.15
597
5520
24
99
2.48
4.01
1.7
1.3
218.00
171.05
au/ml
—
5
30
657
6309
2.55
4.01
17.1
11.8
24.04
23.30
u/l
0.63
647
6133
33
157
2.16
4.00
1.7
2.4
—
—
—
0
0
140
1013
1.48
3.96
4.1
2.3
12.07
12.85
umol/l
0.67
127
941
20
76
2.68
3.93
1.3
1.3
—
—
—
0
0
10
19
5.33
3.84
2.8
2.3
0.60
0.62
mmol/l
—
10
19
33
161
2.10
3.77
4.1
1.3
—
—
—
0
0
25
109
2.34
3.73
1.7
1.4
—
—
—
0
0
93
624
1.57
3.72
3.6
2.3
29.52
37.05
u/l
1.41
73
513
127
913
1.48
3.70
2.0
2.2
196.60
107.52
ug/g
0.70
92
712
605
5681
1.63
3.67
7.8
6.1
38.96
38.72
mmol/mol
0.29
575
5323
153
1142
1.44
3.67
4.2
3.9
139.34
288.05
ng/l
0.71
109
836
39
205
1.96
3.66
4.0
1.3
—
—
—
0
0
86
569
1.59
3.66
4.4
4.3
0.81
1.05
%
0.42
31
149
288
2393
1.35
3.63
4.5
3.3
2.36
2.37
mmol/l
0.27
257
2190
83
546
1.59
3.62
5.5
3.1
105.96
78.16
ng/l
1.51
74
482
257
2102
1.36
3.57
4.0
3.4
—
0.83
—
0
6
96
656
1.54
3.55
2.7
2.1
0.00
0.04
estimate
—
10
128
41
222
1.90
3.54
1.2
1.4
363.83
302.15
ug/g
0.83
24
128
82
543
1.58
3.48
4.3
4.2
0.30
0.78
%
2.30
27
139
374
3247
1.34
3.46
3.9
3.1
104.58
84.51
ug/l
1.60
346
3039
81
536
1.58
3.45
2.6
3.1
184.53
81.50
u/ml
0.28
81
517
22
94
2.39
3.44
5.6
1.4
—
—
—
0
0
82
545
1.57
3.43
4.6
4.4
0.00
0.12
%
2.97
27
126
38
204
1.91
3.37
4.1
1.3
—
—
—
0
0
53
317
1.73
3.33
2.8
2.0
0.00
0.01
estimate
—
9
95
41
227
1.86
3.32
1.9
1.8
20.74
20.13
s
0.41
35
199
42
235
1.84
3.29
6.2
3.5
—
—
—
0
0
21
90
2.38
3.27
1.9
3.3
1.43
1.37
%
0.02
21
83
22
97
2.31
3.23
1.6
1.3
—
—
—
0
0
13
40
3.29
3.15
1.1
1.3
—
—
—
0
0
88
608
1.51
3.10
5.5
3.8
7.35
7.36
ph
0.22
61
417
211
1706
1.34
3.08
1.3
1.3
0.62
1.69
u/ml
2.23
52
466
22
100
2.24
3.02
1.1
1.0
—
—
—
0
0
218
1776
1.34
3.01
1.5
1.5
—
—
—
0
0
187
1489
1.35
3.01
6.2
4.6
—
—
—
0
0
16
63
2.58
2.97
1.6
1.5
—
—
—
0
0
16
63
2.58
2.97
1.6
1.5
—
—
—
0
0
16
63
2.58
2.97
1.6
1.5
—
—
—
0
0
16
63
2.58
2.97
1.6
1.5
—
—
—
0
0
189
1520
1.34
2.83
4.9
4.2
1.02
2.00
kg/l
0.50
132
1021
38
217
1.80
2.82
6.0
1.7
0.22
0.23
g/l
0.24
38
208
254
2132
1.31
2.81
3.9
2.8
29.41
28.80
u/l
0.19
244
2017
14
53
2.68
2.81
1.2
1.3
—
—
—
0
0
31
166
1.91
2.81
4.3
3.7
1.32
2.28
ratio
1.36
22
101
598
5661
1.49
2.81
4.7
4.2
1.31
1.24
mmol/l
2.10
553
5220
12
39
3.11
2.78
1.0
1.1
—
—
—
0
0
14
54
2.63
2.72
2.1
3.2
57.36
53.58
%
0.31
14
48
6
10
6.04
2.70
3.0
2.4
—
—
—
0
0
28
147
1.94
2.69
5.3
3.4
57.16
59.21
%
0.36
28
147
24
119
2.05
2.69
5.8
3.5
3.45
4.35
e9/l
1.73
24
119
665
6488
2.69
2.65
36.6
22.9
267.65
263.29
e9/l
1.02
660
6372
110
821
1.41
2.61
4.1
3.1
4.32
4.63
e9/l
0.30
90
719
665
6490
2.66
2.61
36.6
22.9
6.75
6.61
e9/l
1.11
659
6348
665
6490
2.66
2.61
37.2
23.1
39.22
39.59
%
1.26
660
6427
665
6490
2.66
2.61
36.6
22.9
4.33
4.40
e12/l
3.05
659
6353
62
414
1.55
2.57
2.6
3.1
181.96
195.63
ng/l
0.08
56
389
35
201
1.78
2.57
1.1
1.2
—
—
—
0
0
222
1848
1.30
2.57
4.4
3.5
0.00
0.01
estimate
1.34
75
567
79
556
1.48
2.57
4.7
4.7
0.00
0.18
%
1.66
23
119
264
2249
1.29
2.55
4.3
3.7
24.90
58.30
ng/l
0.64
175
1490
13
50
2.63
2.54
1.2
1.2
—
—
—
0
0
38
225
1.73
2.52
6.1
1.7
1.17
1.22
g/l
0.29
38
213
86
620
1.44
2.48
1.5
1.5
—
—
—
0
0
70
486
1.49
2.44
2.4
2.5
17.66
20.80
au/ml
—
9
45
21
103
2.07
2.44
1.1
1.0
—
—
—
0
0
9
27
3.36
2.40
3.2
2.2
0.78
0.81
index
—
9
27
50
324
1.59
2.37
2.0
2.0
—
—
—
0
0
147
1171
1.33
2.32
2.4
1.8
—
—
—
0
0
14
60
2.36
2.23
2.6
2.6
—
24.95
—
0
6
5
9
5.59
2.21
1.0
1.0
—
—
—
0
0
5
9
5.59
2.21
1.0
1.0
—
—
—
0
0
5
9
5.59
2.21
1.0
1.0
—
—
—
0
0
8
24
3.36
2.18
3.3
3.7
—
—
—
0
0
28
159
1.79
2.17
1.5
1.3
—
—
—
0
0
53
357
1.53
2.15
2.9
2.5
123.11
129.19
g/l
1.51
53
347
11
42
2.65
2.15
1.3
1.6
11.53
11.23
umol/l
0.06
11
36
168
1378
1.29
2.13
3.3
2.6
2.47
2.45
mmol/l
0.54
145
1250
34
206
1.68
2.12
1.5
1.7
—
—
—
0
0
5
10
5.03
2.07
1.0
1.3
—
—
—
0
0
19
97
1.99
2.02
1.0
1.1
2.38
1.61
eliau/ml
—
10
48
38
241
1.61
2.00
1.5
1.2
19.00
2.19
u/ml
—
8
22
38
241
1.61
2.00
1.5
1.2
6.85
8.03
u/ml
—
10
37
66
473
1.44
1.99
4.4
3.6
4.87
4.56
pmol/l
0.47
57
415
52
356
1.50
1.97
1.3
1.2
—
—
—
0
0
6
16
3.77
1.94
1.7
2.1
8.83
8.13
%
—
6
16
15
71
2.14
1.93
2.1
1.9
27.27
22.17
ng/l
0.18
15
71
22
121
1.85
1.90
8.5
3.2
—
—
—
0
0
160
1323
1.27
1.90
1.7
1.7
447.16
29837696.79
pmol/l
1.56
129
1106
8
28
2.88
1.86
3.3
3.3
—
—
—
0
0
40
262
1.56
1.86
1.6
1.6
8.28
10.40
u/ml
—
9
50
5
12
4.19
1.82
2.2
1.9
—
—
—
0
0
15
73
2.08
1.81
1.3
1.7
—
—
—
0
0
9
35
2.59
1.80
2.0
1.3
61.89
69.03
umol/l
—
9
35
70
518
1.39
1.78
6.0
3.9
—
—
—
0
0
14
67
2.11
1.77
3.1
2.7
—
—
—
0
0
6
18
3.35
1.75
1.7
1.9
31.00
26.83
%
—
6
18
68
503
1.39
1.74
1.4
1.3
338.23
183.13
u/ml
0.35
63
468
34
219
1.58
1.71
1.1
1.4
0.37
0.31
mg/l
0.25
15
77
69
514
1.38
1.70
2.9
2.8
65.82
67.45
g/l
0.76
57
479
65
481
1.39
1.67
2.8
2.3
0.42
0.66
e6/l
0.40
65
451
6
19
3.18
1.66
1.0
1.4
—
—
—
0
0
6
19
3.18
1.66
3.8
1.1
—
—
—
0
0
10
41
2.46
1.65
1.0
1.0
—
—
—
0
0
90
704
1.32
1.63
1.7
1.4
—
—
—
0
0
77
589
1.35
1.62
1.2
1.2
—
—
—
0
0
38
547
0.68
1.56
1.4
1.3
—
—
—
0
0
34
225
1.54
1.54
2.6
2.1
9.68
10.11
g/l
0.18
27
207
37
250
1.51
1.53
3.4
2.8
25.43
25.49
mmol/l
0.04
37
244
31
202
1.56
1.51
3.9
2.9
322.33
359.69
mg/l
0.07
15
65
22
131
1.70
1.51
3.2
1.8
—
—
—
0
0
28
178
1.60
1.51
2.1
1.8
188.21
185.72
ug/l
0.01
28
159
606
5861
1.33
1.47
6.4
5.1
5.88
5.82
mmol/l
0.71
563
5410
625
6073
1.39
1.47
6.7
5.7
2.70
2.79
mmol/l
1.67
584
5666
23
140
1.67
1.46
2.8
1.9
118.00
128.32
g/l
1.08
13
109
7
28
2.52
1.45
1.7
1.2
14.86
8.39
mm/h
—
7
28
14
74
1.91
1.40
2.4
2.1
—
—
—
0
0
28
182
1.56
1.39
1.4
1.3
728.43
483.11
mg/l
0.42
28
171
5
17
2.95
1.36
1.0
1.2
30.40
28.88
s
—
5
17
298
2705
1.18
1.36
2.2
1.9
1.35
1.32
mmol/l
0.30
250
2305
5
18
2.79
1.28
1.0
1.1
521.00
372.00
pmol/l
—
5
13
68
531
1.31
1.27
3.1
2.5
6.02
6.14
ph
0.55
43
359
93
759
1.26
1.25
1.5
1.8
—
—
—
0
0
616
5997
1.31
1.19
5.9
5.0
4.70
4.81
mmol/l
2.14
579
5615
6
26
2.32
1.19
1.3
2.2
15.10
16.33
%
—
6
26
8
38
2.12
1.18
1.5
1.1
—
—
—
0
0
10
50
2.02
1.17
2.9
3.6
—
—
—
0
0
22
142
1.57
1.15
1.4
1.5
—
—
—
0
0
8
39
2.06
1.15
1.6
1.4
14.88
27.91
ug/l
—
8
39
18
111
1.64
1.13
1.3
1.2
2.10
5.19
u/ml
—
10
42
7
30
2.35
1.12
1.7
1.9
1.34
1.00
nmol/l
—
7
22
15
89
1.70
1.08
1.2
1.2
—
—
—
0
0
13
74
1.77
1.07
2.5
1.7
5.05
57.34
u/ml
0.52
13
74
612
5966
1.28
1.06
5.7
4.9
1.54
1.59
mmol/l
2.15
572
5555
9
46
1.97
1.04
1.0
1.1
—
—
—
0
0
7
34
2.07
1.03
1.3
1.1
17.18
28.80
nmol/l
—
7
26
33
241
1.39
0.98
1.5
1.3
272.77
247.50
miu/ml
0.15
13
113
5
23
2.18
0.98
2.2
1.3
—
—
—
0
0
23
157
1.48
0.97
1.3
1.4
32.59
15.16
e6/l
0.22
17
114
23
158
1.47
0.94
1.3
1.5
9.67
129.50
e6/l
2.16
18
119
16
101
1.60
0.94
1.1
1.2
—
—
—
0
0
6
28
2.15
0.91
2.0
1.6
—
—
—
0
0
10
56
1.80
0.88
2.9
2.7
—
—
—
0
0
14
87
1.62
0.88
4.4
6.4
296.64
377.27
umol/l
1.87
14
81
76
637
1.22
0.84
3.1
3.9
3.32
8.67
ug/l
3.31
60
508
70
583
1.22
0.83
1.1
1.2
139.24
154.22
u/ml
0.13
23
239
54
437
1.26
0.82
3.1
2.4
—
—
—
0
0
24
172
1.41
0.82
1.2
1.2
—
—
—
0
0
15
97
1.56
0.82
1.1
1.1
—
—
—
0
0
14
89
1.59
0.81
1.2
1.2
0.20
0.18
nmol/l
—
9
66
14
89
1.59
0.81
1.1
1.2
—
—
—
0
0
6
33
1.83
0.79
1.0
1.1
—
12.20
—
0
5
11
66
1.68
0.79
2.2
1.8
65.67
56.69
%
—
6
42
6
34
1.77
0.76
4.7
3.8
818.17
1001.88
u/ml
—
6
34
13
83
1.58
0.75
1.0
1.1
—
—
—
0
0
17
116
1.48
0.75
3.8
2.3
16.15
15.99
%
0.08
17
116
38
299
1.29
0.74
1.1
1.1
—
—
—
0
0
160
1446
1.14
0.73
1.3
1.4
21.73
29.99
iu/ml
1.01
46
459
7
39
1.80
0.72
1.0
1.3
—
—
—
0
0
9
56
1.62
0.72
2.6
2.0
—
—
—
0
0
10
60
1.68
0.72
1.1
1.3
0.31
0.35
g/l
—
10
46
15
216
0.69
0.70
1.3
1.1
1.76
1.63
g/l
0.65
15
216
10
61
1.65
0.69
1.1
1.3
—
—
—
0
0
7
42
1.67
0.68
1.3
1.6
5.97
5.93
ug/l
—
7
35
7
43
1.63
0.67
1.1
1.1
1.09
1.06
ratio
—
7
37
27
349
0.76
0.66
1.4
1.6
965.60
991.37
mu/l
0.05
19
289
7
44
1.60
0.65
1.9
1.3
—
—
—
0
0
5
29
1.73
0.64
1.2
1.1
—
—
—
0
0
11
71
1.56
0.62
3.5
2.7
—
—
—
0
0
59
500
1.20
0.62
1.4
1.7
3.65
3.46
mmol/l
0.47
32
356
8
50
1.61
0.61
1.0
1.1
—
—
—
0
0
13
88
1.49
0.61
1.2
1.3
—
—
nmol/l
—
0
0
17
122
1.40
0.60
1.1
1.1
—
—
—
0
0
17
122
1.40
0.60
1.1
1.1
—
—
—
0
0
78
680
1.17
0.60
1.8
1.7
—
—
—
0
0
61
521
1.19
0.59
5.4
3.6
1.23
1.23
mmol/l
0.44
51
451
16
116
1.39
0.55
2.4
3.4
158.74
2781.46
u/ml
0.66
16
111
27
213
1.28
0.54
1.8
1.2
—
—
—
0
0
16
119
1.35
0.48
2.6
1.5
—
—
—
0
0
7
46
1.53
0.48
2.1
1.6
—
—
—
0
0
10
68
1.48
0.47
1.6
2.1
89.64
90.23
%
—
10
68
7
48
1.46
0.47
1.9
1.2
1768.00
1573.90
e6/l
—
7
31
146
1352
1.10
0.46
1.4
1.3
8.83
10.78
u/ml
0.15
53
518
21
166
1.27
0.44
1.0
1.1
—
—
—
0
0
5
31
1.62
0.43
2.8
2.0
40.42
46.06
ug/l
—
5
31
5
33
1.52
0.41
4.6
2.2
496.40
488.54
min
—
5
24
29
241
1.21
0.40
1.4
1.4
234.76
286.46
pmol/l
0.12
29
236
32
270
1.19
0.39
1.4
1.3
—
—
—
0
0
5
36
1.39
0.38
4.4
2.4
505.00
612.50
ml
—
5
24
37
321
1.16
0.34
2.3
2.4
—
—
—
0
0
21
177
1.19
0.27
11.3
9.5
—
—
—
0
0
8
67
1.20
0.26
1.1
1.0
—
—
—
0
0
49
444
1.11
0.26
1.2
1.3
33.44
28.73
iu/l
0.35
40
395
11
135
0.81
0.22
1.0
1.1
0.36
2.29
u/ml
—
6
69
0
11
0.00
0.21
0.0
1.7
—
7.27
—
0
11
0
11
0.00
0.21
0.0
1.9
—
110.91
—
0
11
0
11
0.00
0.21
0.0
1.2
—
1.57
—
0
11
0
12
0.00
0.21
0.0
2.2
—
3.60
—
0
6
0
12
0.00
0.21
0.0
1.0
—
5.96
—
0
12
14
166
0.84
0.20
1.4
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
6
50
1.20
0.19
1.0
1.1
—
—
—
0
0
232
2386
0.96
0.19
3.3
3.1
—
—
—
0
0
6
53
1.13
0.18
1.0
1.3
—
—
—
0
0
14
164
0.85
0.18
1.4
1.5
1.44
1.31
mm
—
9
122
7
58
1.21
0.18
1.0
1.0
—
—
—
0
0
8
70
1.14
0.16
1.3
2.6
—
—
—
0
0
10
83
1.21
0.15
1.0
1.7
—
—
—
0
0
55
517
1.07
0.15
1.3
1.3
—
—
—
0
0
25
226
1.11
0.15
2.7
1.9
2.69
29.62
iu/l
0.54
12
92
15
171
0.87
0.15
1.5
1.6
—
—
—
0
0
12
139
0.86
0.14
6.1
4.9
—
—
—
0
0
19
211
0.90
0.13
1.5
1.6
57.44
58.70
ug/l
0.04
14
179
5
48
1.04
0.09
1.0
1.2
—
—
—
0
0
5
48
1.04
0.09
2.0
1.8
6.62
6.71
mmol/l
—
5
32
11
97
1.14
0.09
1.1
1.0
0.79
2.27
u/ml
—
6
39
11
97
1.14
0.09
1.1
1.2
—
—
—
0
0
10
88
1.14
0.08
3.4
2.4
—
—
—
0
0
43
420
1.03
0.02
1.9
1.8
—
—
—
0
0
12
128
0.94
0.02
3.4
3.7
26.29
23.97
mg/l
—
7
80
23
225
1.02
0.00
3.4
2.9
25.50
783.01
u/ml
0.69
16
197
28
278
1.01
0.00
1.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.8
—
7.58
—
0
8
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
72
0.97
-0.00
1.6
2.2
105.57
105.51
mmol/l
—
7
72
7
72
0.97
-0.00
1.6
2.2
3.89
3.96
mmol/l
—
7
72
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.2
—
0.25
—
0
6
0
6
0.00
-0.00
0.0
6.5
—
5.15
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
34.26
—
0
5
7
72
0.97
-0.00
1.6
2.2
1.18
1.20
mmol/l
—
7
72
0
6
0.00
-0.00
0.0
3.2
—
3.83
—
0
6
7
69
1.01
-0.00
1.3
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
0.03
—
0
7
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
6
63
0.95
-0.00
1.3
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
59.43
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
79
1.01
-0.00
1.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint N14_VULVAL_HSIL and mortality.

Females

Parameter HR [95% CI] p-value
N14_VULVAL_HSIL 1.464 [1.23, 1.74] < 0.001
Birth year 0.993 [0.98, 1.0] 0.114

During the follow-up period (1.1.1998 — 31.12.2019), 378 out of 2373 females with N14_VULVAL_HSIL died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_VULVAL_HSIL.

N-year risk Females Males
1 0.119% No data
5 0.772% No data
10 2.04% No data
15 3.618% No data
20 6.301% No data

Relationships between endpoints

Index endpoint: N14_VULVAL_HSIL – HSIL lesion of the vulva

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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