Dysplastic lesion of unknown severity in the cervix uteri, vagina or vulva

N14_FEMALE_GENITAL_DYSPLASIA_NOS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

only females

313377

2. Check conditions

None

313377

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

532

4. Check minimum number of events

None

532

5. Include endpoints

None

532

6. Filter based on genotype QC (FinnGen only)

500

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF7

Similar endpoints

List of similar endpoints to Dysplastic lesion of unknown severity in the cervix uteri, vagina or vulva based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2793 2793 -
Only index persons 2743 2743 -
Unadjusted period prevalence (%)
Whole population 0.08 0.08 -
Only index persons 0.10 0.10 -
Median age at first event (years)
Whole population - 41.62 -
Only index persons - 41.33 -

-FinnGen-

Key figures

All Female Male
Number of individuals 500 500 -
Unadjusted period prevalence (%) 0.18 0.18 -
Median age at first event (years) 43.37 43.37 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
514
Matched controls
5140
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N87.9
ICD-10 Finland
Dysplasia of cervix uteri, unspecified
3991.8
307.7
417
5
ULA02
NOMESCO Finland
Kolposcopy
20.6
277.6
357
510
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
13.9
200.4
257
345
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
16.3
189.2
193
183
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
10.2
158.8
276
524
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
9.5
149.6
289
612
LDA10
NOMESCO Finland
Curettage of cervix uteri
11.7
126.7
153
180
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
11.9
91.5
102
105
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
13.4
84.1
85
75
N87.0
ICD-10 Finland
Mild cervical dysplasia
11.2
83.7
97
105
N90.3
ICD-10 Finland
Dysplasia of vulva, unspecified
+∞
61.7
58
*
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
10.3
54.2
64
70
N87.1
ICD-10 Finland
Moderate cervical dysplasia
8.5
50.0
69
92
N89.3
ICD-10 Finland
Dysplasia of vagina, unspecified
+∞
45.5
43
*
LEB00
NOMESCO Finland
Biopsy of vagina
10.8
44.3
50
51
A63.0
ICD-10 Finland
Anogenital (venereal) warts
5.9
35.2
68
129
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.7
27.4
302
1757
N90.2
ICD-10 Finland
Severe vulvar dysplasia, not elsewhere classified
43.6
17.4
21
5
R87.5
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal microbiological findings
4.9
16.4
37
80
LFC00
NOMESCO Finland
Partial excision of vulva
35.1
13.6
17
5
N90.0
ICD-10 Finland
Mild vulvar dysplasia
29.2
13.0
17
6
WX702
NOMESCO Finland
Supraglottic ventilation device
3.3
12.8
52
172
X86
ICPC
Abnormal cervix smear
5.9
11.1
20
35
LCA06
NOMESCO Finland
Biopsy of endometrium
2.1
10.5
111
586
D07.1
ICD-10 Finland
Carcinoma in situ: Vulva
+∞
10.4
10
*
R87.9
ICD-10 Finland
Abnormal findings in specimens from female genital organs, unspecified abnormal finding
17.9
9.4
14
8
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
2.0
9.3
111
611
ZXC00
NOMESCO Finland
Use of diathermy
14.0
9.2
15
11
WX725
NOMESCO Finland
Noninvasive ventilation
3.0
8.9
41
146
LFB10
NOMESCO Finland
Excision of lesion of vulva or perineum
9.7
8.8
17
18
WX704
NOMESCO Finland
Intubation
2.5
8.8
58
249
8140/2-C53.9
ICD-O-3
Adenocarcinoma in situ, NOS, of cervix uteri
28.0
8.5
11
*
SPAT1193
SPAT
Pap smear
2.0
8.5
99
539
D06.0
ICD-10 Finland
Carcinoma in situ: Endocervix
13.0
8.4
14
11
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
8.0
109
625
TLW99
NOMESCO Finland
Other minor surgical procedure in gynaecology
3.7
7.5
24
68
LCD31
NOMESCO Finland
Radical laparoscopic hysterectomy
81.2
7.4
8
*
8077/2-C52.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vagina, NOS
81.2
7.4
8
*
N89.1
ICD-10 Finland
Moderate vaginal dysplasia
16.0
7.3
11
7
SPAT1324
SPAT
Screening procedure
1.7
7.0
165
1114
N97.9
ICD-10 Finland
Female infertility, unspecified
2.2
6.8
57
273
A63.8
ICD-10 Finland
Other specified predominantly sexually transmitted diseases
17.0
6.8
10
6
8077/2-C51.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vulva, NOS
22.9
6.7
9
*
LDB20
NOMESCO Finland
Electrocoagulation or laser therapy of cervix uteri
6.0
6.7
17
29
LFB20
NOMESCO Finland
Destruction of lesion of vulva or perineum
8.9
6.6
13
15
SPAT1263
SPAT
Sampling
1.6
6.4
217
1603
N89.2
ICD-10 Finland
Severe vaginal dysplasia, not elsewhere classified
18.3
6.3
9
5
8071/2-C51.9
ICD-O-3
Differentiated intraepithelial neoplasia of vulva, NOS
+∞
6.3
6
*
N89.0
ICD-10 Finland
Mild vaginal dysplasia
8.7
6.1
12
14
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.5
6.0
36
148

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
125
172
9.28
90.17
2.5
1.8
—
—
—
0
0
45
217
2.18
5.27
2.6
2.5
84.35
141.63
ng/l
0.81
40
199
154
1096
1.58
5.05
4.0
3.3
1.02
2.42
kg/l
0.50
106
721
255
2066
1.46
4.37
2.8
2.0
—
—
—
0
0
181
1389
1.47
4.02
2.9
2.3
54.72
61.37
u/l
0.95
170
1302
22
90
2.51
3.77
2.0
2.1
13.18
13.25
%
0.10
22
90
115
824
1.51
3.53
1.4
1.4
508.15
582.50
titre
0.14
27
192
59
365
1.70
3.34
1.4
1.4
—
—
—
0
0
149
1138
1.44
3.29
1.4
1.4
18.84
30.03
iu/ml
1.46
54
361
75
498
1.59
3.23
2.0
2.4
5.59
5.35
umol/l
0.10
61
430
160
1248
1.41
3.12
5.1
3.5
7.40
7.40
ph
0.04
121
875
298
2575
1.37
3.11
4.1
3.6
0.00
0.02
estimate
1.08
62
519
36
199
1.87
2.98
2.0
1.7
—
—
—
0
0
294
2552
1.36
2.89
4.1
3.5
21.67
5.43
estimate
0.33
64
537
220
1830
1.35
2.84
4.5
4.2
36.07
36.83
g/l
1.25
211
1735
231
1952
1.33
2.63
4.1
3.3
0.00
0.03
estimate
1.87
51
443
289
2530
1.33
2.54
4.1
3.5
0.00
0.00
estimate
0.50
62
536
48
307
1.62
2.43
3.7
2.9
2.47
2.01
mmol/l
0.50
40
264
264
2301
1.30
2.31
5.5
5.7
9.90
9.53
umol/l
0.44
251
2193
9
28
3.25
2.31
2.0
2.2
42.04
48.91
%
—
9
15
166
1362
1.32
2.25
4.2
3.6
0.00
0.01
estimate
1.08
60
521
58
396
1.52
2.24
2.6
3.8
4.57
4.63
pmol/l
0.17
52
359
16
73
2.23
2.23
1.2
1.4
—
84.21
—
0
7
239
2063
1.30
2.23
6.3
5.8
1.22
1.22
mmol/l
0.04
213
1793
8
192
0.41
2.09
1.5
1.3
—
—
—
0
0
39
248
1.62
2.05
1.3
1.3
2.12
0.86
u/ml
—
6
15
17
83
2.08
2.03
1.0
1.1
—
—
—
0
0
131
1053
1.33
2.03
1.4
1.3
11.65
13.94
u/ml
0.13
54
443
70
509
1.43
2.00
1.5
1.6
—
—
—
0
0
193
1639
1.28
1.99
4.3
3.0
32.50
27.74
u/l
0.73
183
1556
8
29
2.79
1.80
1.1
1.2
—
—
—
0
0
53
375
1.46
1.76
2.2
2.2
0.22
0.22
g/l
0.08
46
360
368
3410
1.28
1.74
8.3
7.3
73.13
74.81
u/l
0.43
351
3248
10
40
2.53
1.67
1.4
1.1
—
—
—
0
0
31
197
1.61
1.67
1.2
1.2
—
—
—
0
0
29
447
0.63
1.66
1.9
1.8
—
—
—
0
0
16
83
1.96
1.66
1.3
1.7
0.68
0.61
g/l
0.12
11
66
11
49
2.27
1.64
1.2
1.4
—
—
—
0
0
12
236
0.50
1.63
1.5
2.0
0.17
0.01
estimate
—
6
87
26
159
1.67
1.62
3.8
5.8
—
—
—
0
0
327
3001
1.25
1.61
3.8
3.3
—
0.00
—
0
5
10
43
2.35
1.59
6.2
2.7
—
—
—
0
0
252
2254
1.23
1.56
2.7
2.6
—
—
estimate
—
0
0
105
850
1.30
1.54
1.8
1.7
448.87
37162599.91
pmol/l
1.31
93
740
7
27
2.61
1.52
3.6
2.1
472.86
507.00
e6/l
—
7
21
163
1395
1.25
1.51
5.7
5.9
—
—
—
0
0
18
101
1.81
1.50
1.3
1.4
—
—
—
0
0
187
1629
1.23
1.47
8.2
7.9
1.11
1.09
inr
0.20
159
1343
88
701
1.31
1.45
1.8
2.0
—
—
—
0
0
166
1432
1.24
1.42
3.3
2.6
—
—
—
0
0
86
687
1.30
1.39
2.6
2.2
14.82
14.20
umol/l
0.35
78
643
32
215
1.52
1.39
4.1
2.4
2.38
5.24
ug/l
2.24
32
191
24
369
0.63
1.39
3.3
3.5
7.38
7.36
ph
0.33
14
263
277
2522
1.21
1.38
6.8
6.3
0.17
0.17
e9/l
0.09
260
2253
44
317
1.42
1.36
3.6
2.9
7.38
7.39
ph
0.20
30
188
93
755
1.28
1.34
2.5
2.5
112.77
91.73
ug/g
0.18
71
593
10
193
0.51
1.32
1.2
1.8
—
—
—
0
0
31
214
1.48
1.21
2.0
2.1
—
—
—
0
0
77
619
1.29
1.20
3.5
2.5
5.41
4.85
e6/l
0.12
43
257
169
1486
1.20
1.18
3.3
3.0
0.00
0.14
estimate
0.65
48
447
79
640
1.28
1.17
2.6
2.2
2.44
2.43
g/l
0.06
70
587
59
460
1.32
1.16
1.7
1.4
—
—
—
0
0
422
4039
1.25
1.15
17.9
15.4
13.41
13.42
%
0.06
416
3996
0
36
0.00
1.14
0.0
1.3
—
68.83
—
0
36
445
4588
0.78
1.13
5.0
5.0
2.84
2.84
mmol/l
0.03
423
4372
85
699
1.26
1.12
3.0
3.2
107.11
272.75
ng/l
0.59
54
405
7
138
0.50
1.11
2.6
3.6
—
—
—
0
0
71
572
1.28
1.10
2.9
2.3
24.10
23.48
%
0.15
65
535
54
419
1.32
1.10
1.8
2.1
2950.54
7145.57
u/l
0.97
17
182
25
170
1.49
1.07
2.2
2.2
0.63
0.61
%
0.13
25
170
10
52
1.94
1.06
1.5
1.3
—
—
—
0
0
10
52
1.94
1.06
1.5
1.3
—
—
—
0
0
10
52
1.94
1.06
1.5
1.3
—
—
—
0
0
10
52
1.94
1.06
1.5
1.3
—
—
—
0
0
331
3107
1.18
1.05
5.4
4.3
2868.33
1594.32
e6/l
—
6
34
26
179
1.48
1.05
3.3
1.7
1.17
1.22
g/l
0.47
26
174
14
226
0.61
1.03
1.4
1.5
—
—
—
0
0
442
4552
0.79
1.01
4.5
4.5
4.82
4.84
mmol/l
0.12
429
4354
84
699
1.24
1.00
1.8
1.5
—
—
—
0
0
7
36
1.96
0.97
1.0
1.0
—
—
—
0
0
268
2486
1.16
0.95
6.9
5.9
1.91
1.96
e9/l
0.38
254
2247
22
150
1.49
0.94
1.4
1.5
—
11.42
—
0
5
7
37
1.90
0.94
1.9
2.3
1.20
1.19
mmol/l
—
7
37
7
37
1.90
0.94
1.4
1.1
—
—
—
0
0
225
2061
1.16
0.94
3.9
3.1
6.32
6.24
ph
0.54
133
1190
472
4602
1.31
0.92
14.5
12.4
21.00
19.09
mg/l
0.64
383
3673
20
135
1.50
0.90
1.4
1.2
—
—
—
0
0
45
353
1.30
0.88
4.3
7.3
7.44
7.41
ph
1.68
31
196
69
572
1.24
0.87
2.3
1.8
—
—
—
0
0
240
2219
1.15
0.86
7.1
5.9
8.18
8.33
%
0.43
226
2094
8
44
1.83
0.86
1.0
1.1
106.38
118.70
pmol/l
—
8
44
15
96
1.58
0.85
1.2
1.2
163.00
243.57
u/ml
—
8
59
60
491
1.25
0.85
1.7
1.4
—
—
—
0
0
442
4538
0.81
0.84
4.4
4.4
1.54
1.57
mmol/l
0.73
424
4319
44
347
1.29
0.83
4.3
7.2
1.81
0.93
mmol/l
1.04
36
285
239
2214
1.15
0.83
7.1
5.9
0.64
0.70
%
0.91
224
2077
13
81
1.62
0.82
1.1
1.1
—
—
—
0
0
239
2218
1.14
0.80
6.8
5.8
2.74
2.76
%
0.03
225
2091
13
82
1.60
0.78
2.5
2.2
8.72
8.16
kpa
0.84
13
82
0
26
0.00
0.78
0.0
3.6
—
—
—
0
0
349
3327
1.15
0.78
3.2
3.1
40.42
35.82
u/l
0.57
333
3205
7
125
0.55
0.78
1.3
1.7
—
—
—
0
0
74
629
1.21
0.75
1.3
1.2
—
—
—
0
0
7
38
1.85
0.73
1.9
2.4
4.11
3.99
mmol/l
—
7
38
7
38
1.85
0.73
1.9
2.4
102.71
106.55
mmol/l
—
7
38
259
2428
1.13
0.73
6.7
6.0
0.04
0.04
e9/l
0.10
236
2134
64
538
1.22
0.73
1.2
1.3
124.74
141.69
u/ml
0.15
30
242
245
2290
1.13
0.72
6.8
5.8
29.92
29.33
%
0.42
234
2187
9
57
1.59
0.71
1.6
1.9
—
—
—
0
0
5
26
1.93
0.71
1.6
1.1
—
—
—
0
0
258
2422
1.13
0.70
6.8
5.9
0.52
0.52
e9/l
0.08
236
2132
10
61
1.65
0.69
1.8
2.1
—
—
—
0
0
9
59
1.53
0.68
1.0
1.1
—
—
—
0
0
7
121
0.57
0.68
1.9
3.5
59.14
58.76
%
—
7
121
19
136
1.41
0.67
1.9
2.3
1.49
1.34
g/l
0.32
14
118
100
883
1.16
0.67
4.3
2.4
8.13
9.13
e6/l
0.15
87
799
286
2708
1.13
0.66
8.5
9.0
3.89
3.91
e9/l
0.07
261
2389
21
281
0.74
0.66
1.2
1.5
—
—
—
0
0
23
172
1.35
0.65
2.1
2.2
1.47
1.20
%
0.44
23
172
131
1183
1.14
0.65
1.6
1.6
20.64
21.28
nmol/l
0.21
116
1040
19
257
0.73
0.64
1.3
1.5
—
—
—
0
0
145
1320
1.14
0.63
4.8
2.8
20.12
78.35
e6/l
1.59
113
962
92
812
1.16
0.62
1.4
1.5
—
—
—
0
0
21
278
0.74
0.62
1.2
1.5
—
—
—
0
0
21
278
0.74
0.62
1.2
1.5
—
—
—
0
0
13
88
1.49
0.61
1.5
2.1
5.86
5.20
mmol/24h
0.32
13
76
21
277
0.75
0.61
1.2
1.5
—
—
—
0
0
45
373
1.23
0.60
1.6
2.1
6.39
6.14
ph
1.05
32
232
14
197
0.70
0.60
1.1
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
132
1200
1.13
0.59
1.9
1.7
—
—
—
0
0
0
23
0.00
0.58
0.0
1.7
—
—
—
0
0
487
4800
1.28
0.57
11.6
10.6
25.64
23.81
u/l
0.50
477
4697
26
203
1.30
0.57
1.1
1.6
0.31
0.28
mg/l
0.10
14
83
121
1327
0.88
0.55
4.3
3.2
6.86
7.40
mmol/l
0.73
111
1141
9
63
1.44
0.52
1.6
1.8
67.00
60.44
%
—
9
63
14
100
1.41
0.52
8.6
3.1
2.63
1.73
index
—
8
51
34
280
1.23
0.50
1.1
1.1
—
—
—
0
0
10
143
0.69
0.48
1.3
1.2
—
—
—
0
0
41
347
1.20
0.47
3.1
4.3
11.98
8.02
ug/l
0.25
33
267
33
395
0.82
0.46
3.4
4.9
0.00
0.18
%
—
6
83
237
2253
1.10
0.46
6.8
5.7
56.44
56.60
%
0.08
229
2162
123
1134
1.11
0.44
4.6
2.7
0.33
0.35
e6/l
0.04
92
788
7
51
1.38
0.44
1.6
1.5
16.50
21.89
ng/l
—
7
51
12
87
1.39
0.42
1.7
2.1
—
—
—
0
0
135
1256
1.10
0.41
4.0
4.5
—
—
—
0
0
5
33
1.52
0.41
3.6
3.8
0.86
0.86
nmol/l
—
5
27
34
288
1.19
0.40
1.1
1.1
—
195.71
—
0
7
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
192
1819
1.09
0.40
6.7
5.0
1.22
1.22
mmol/l
0.23
180
1690
56
630
0.88
0.39
1.2
1.3
—
—
—
0
0
257
2466
1.08
0.39
4.3
4.1
6.38
6.34
mmol/l
0.13
237
2267
0
19
0.00
0.39
0.0
2.2
—
1.49
—
0
19
0
19
0.00
0.39
0.0
2.5
—
507.77
—
0
13
31
262
1.19
0.38
5.5
6.9
—
—
—
0
0
9
69
1.31
0.37
1.2
2.2
—
—
—
0
0
24
287
0.83
0.35
1.6
1.6
—
—
—
0
0
59
529
1.13
0.35
1.4
1.3
—
—
—
0
0
9
126
0.71
0.35
13.7
5.7
—
—
—
0
0
151
1428
1.08
0.32
3.6
3.1
70.68
106.62
ng/l
0.19
68
777
110
1176
0.92
0.32
5.1
4.1
8.39
8.95
mg/mmol
0.06
69
687
77
837
0.91
0.32
2.2
2.3
2.41
2.43
mmol/l
1.24
65
760
202
2106
0.93
0.31
10.5
9.8
0.00
0.00
e9/l
1.03
175
1732
122
1147
1.08
0.30
1.6
1.8
0.76
0.93
mg/l
0.64
97
884
7
54
1.30
0.30
1.1
1.1
—
—
—
0
0
427
4334
0.91
0.30
4.4
4.3
5.63
5.67
mmol/l
0.38
400
4088
84
777
1.10
0.30
3.6
2.6
506.14
501.49
mosm/kgh2o
0.07
73
683
29
250
1.17
0.30
3.5
2.0
17.68
7.50
iu/ml
0.48
11
59
101
943
1.09
0.30
4.0
3.6
—
—
—
0
0
25
291
0.85
0.29
1.7
1.3
269.49
241.87
miu/ml
—
10
145
34
386
0.87
0.29
3.3
4.4
0.75
0.85
%
—
8
96
7
57
1.23
0.29
2.9
1.6
2.69
71.66
u/ml
—
7
57
11
85
1.30
0.28
5.9
4.0
—
—
—
0
0
34
300
1.14
0.27
2.1
1.7
—
—
—
0
0
8
66
1.22
0.27
1.1
1.3
—
—
—
0
0
24
278
0.86
0.26
1.5
1.5
—
—
—
0
0
18
214
0.84
0.26
2.3
3.2
4.94
5.14
kpa
0.56
18
209
12
95
1.27
0.26
1.3
1.2
—
—
—
0
0
39
435
0.89
0.26
1.6
1.9
0.27
0.05
estimate
0.36
11
104
164
1569
1.07
0.26
2.6
3.2
2.33
2.36
mmol/l
1.62
154
1464
5
73
0.68
0.26
1.0
1.2
—
—
—
0
0
43
387
1.12
0.26
1.2
1.3
—
—
—
0
0
282
2744
1.06
0.26
3.4
3.2
89.11
70.98
ug/l
1.26
275
2615
36
403
0.89
0.26
3.2
4.5
0.72
1.17
%
—
9
105
10
127
0.78
0.25
1.1
1.3
3.26
3.69
mmol/l
—
10
119
9
75
1.20
0.25
2.1
2.7
—
23.04
—
0
5
66
611
1.09
0.24
1.7
1.7
1288.09
1181.92
nmol/l
0.41
57
462
9
77
1.17
0.24
1.8
1.2
—
—
—
0
0
423
4285
0.93
0.24
3.6
3.7
1.23
1.20
mmol/l
0.45
403
4049
408
4020
1.07
0.24
5.2
5.0
14.29
14.41
pmol/l
0.54
389
3804
24
275
0.87
0.24
1.5
1.5
1.20
1.29
mm
0.46
18
196
150
1566
0.94
0.24
1.7
1.7
—
—
—
0
0
59
544
1.10
0.24
1.2
1.3
30.01
26.15
iu/l
0.41
54
479
45
410
1.11
0.23
3.2
2.2
49.29
35.36
u/l
0.48
35
342
144
1379
1.06
0.22
1.3
1.3
0.61
1.86
u/ml
1.84
38
386
7
94
0.74
0.22
1.9
3.6
4.00
4.32
e9/l
—
7
94
5
42
1.19
0.21
3.8
1.6
14.80
6.55
ug/l
—
5
37
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
0.02
—
0
11
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
499
5014
0.84
0.21
22.0
19.7
6.74
6.63
e9/l
0.63
493
4932
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
6
48
1.25
0.20
1.0
1.2
—
—
—
0
0
499
5013
0.84
0.20
21.9
19.7
4.39
4.44
e12/l
2.34
493
4937
12
99
1.22
0.19
1.4
1.1
—
—
—
0
0
35
384
0.90
0.19
3.2
4.6
0.00
0.16
%
—
8
86
413
4177
0.94
0.18
5.7
5.2
37.65
37.65
mmol/mol
0.00
393
3993
99
945
1.06
0.17
1.7
1.8
—
—
—
0
0
447
4507
0.94
0.16
6.0
6.0
1.72
1.75
mu/l
0.35
429
4302
17
193
0.88
0.16
2.1
2.1
2.01
4.52
iu/l
—
6
78
6
78
0.77
0.15
1.0
1.3
—
—
—
0
0
107
1111
0.95
0.14
1.9
2.0
—
—
—
0
0
14
160
0.87
0.14
1.1
1.1
—
—
—
0
0
51
541
0.94
0.14
1.2
1.7
3.19
3.40
mmol/l
0.79
32
388
111
1150
0.96
0.14
4.6
3.4
58.25
42.96
mg/l
0.30
74
704
232
2274
1.04
0.14
2.8
2.5
73.89
76.71
nmol/l
0.78
217
2125
8
97
0.82
0.14
1.3
1.0
—
—
—
0
0
153
1489
1.04
0.13
6.8
5.8
—
—
—
0
0
11
94
1.17
0.13
1.0
1.2
1.40
5.94
u/ml
—
5
32
106
1024
1.04
0.13
2.5
2.3
298.83
302.13
umol/l
0.15
95
931
168
1641
1.04
0.12
5.2
3.4
55.96
68.92
e6/l
0.24
122
1048
184
1880
0.97
0.12
1.9
2.0
92.43
99.21
pmol/l
1.32
103
1008
60
572
1.06
0.12
1.5
1.3
—
—
—
0
0
142
1387
1.03
0.10
2.2
2.0
—
—
—
0
0
27
252
1.08
0.09
11.0
7.0
8.47
7.81
mmol/l
0.21
27
242
27
252
1.08
0.09
1.9
2.8
71.24
74.80
e9/l
0.20
21
184
10
88
1.14
0.08
3.1
4.0
34.24
26.40
mg/l
—
10
75
10
88
1.14
0.08
3.0
4.0
46.55
31.33
mg/l
—
10
77
147
1498
0.97
0.08
2.1
2.0
—
—
—
0
0
7
67
1.05
0.08
2.0
1.8
—
—
—
0
0
205
2079
0.98
0.08
2.6
2.7
—
—
—
0
0
7
68
1.03
0.08
1.7
2.5
32.00
31.17
umol/l
—
7
60
197
1943
1.02
0.07
1.9
1.9
1.30
1.33
mmol/l
0.30
176
1711
7
85
0.82
0.07
2.1
2.3
—
—
—
0
0
8
90
0.89
0.07
1.4
2.1
4.49
6.15
pmol/l
—
8
90
31
295
1.05
0.06
1.3
1.2
—
—
—
0
0
30
315
0.95
0.06
2.5
3.5
1.22
1.23
mmol/l
0.46
25
273
42
404
1.04
0.06
4.2
3.7
—
—
—
0
0
10
111
0.90
0.06
1.0
1.7
—
—
—
0
0
13
141
0.92
0.05
1.0
1.1
—
—
—
0
0
13
141
0.92
0.05
1.0
1.1
—
—
—
0
0
13
141
0.92
0.05
1.3
1.3
250.50
336.56
ug/g
—
6
84
15
140
1.07
0.04
2.9
3.4
297.63
234.87
mg/l
—
8
52
11
118
0.93
0.03
1.0
1.1
5.75
3.97
u/ml
—
6
55
26
251
1.04
0.02
1.1
1.2
0.82
0.89
g/l
0.87
26
251
59
580
1.02
0.02
1.6
1.6
1007.45
1011.85
mu/l
0.01
50
482
121
1199
1.01
0.02
2.5
2.2
2.46
2.71
mg/l
0.89
111
1050
453
4522
1.01
0.01
15.4
13.0
3.91
3.91
mmol/l
0.08
447
4416
25
244
1.03
0.00
1.1
1.1
1.63
1.61
g/l
0.23
25
244
452
4514
1.01
0.00
15.3
13.0
139.45
139.68
mmol/l
1.04
446
4423
22
225
0.98
0.00
1.4
1.2
—
—
—
0
0
28
285
0.98
0.00
1.1
1.1
—
—
—
0
0
479
4795
0.98
0.00
12.7
11.3
—
—
—
0
0
30
304
0.99
0.00
3.8
5.7
1.22
1.20
mmol/l
0.05
30
298
65
646
1.01
0.00
1.2
1.2
—
—
—
0
0
20
198
1.01
0.00
2.5
2.3
—
—
—
0
0
47
468
1.00
0.00
1.1
1.2
—
—
—
0
0
13
131
0.99
0.00
1.2
1.3
—
—
—
0
0
118
1182
1.00
0.00
1.5
1.4
2.42
2.18
g/l
0.71
73
767
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
77.17
—
0
6
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
9
95
0.95
-0.00
1.3
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.5
—
6.72
—
0
6
7
69
1.01
-0.00
1.1
1.5
—
—
—
0
0
6
60
1.00
-0.00
1.7
1.3
15.71
35.03
nmol/l
—
6
49
0
7
0.00
-0.00
0.0
1.3
—
9.26
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.03
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
4.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
0.17
—
0
6
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
25.08
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
132.66
—
0
9
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
15.93
—
0
5

Mortality – FinRegistry

Association

Association between endpoint N14_FEMALE_GENITAL_DYSPLASIA_NOS and mortality.

Females

Parameter HR [95% CI] p-value
N14_FEMALE_GENITAL_DYSPLASIA_NOS 1.288 [1.06, 1.57] 0.012
Birth year 0.995 [0.99, 1.0] 0.254

During the follow-up period (1.1.1998 — 31.12.2019), 177 out of 2382 females with N14_FEMALE_GENITAL_DYSPLASIA_NOS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_FEMALE_GENITAL_DYSPLASIA_NOS.

N-year risk Females Males
1 0.127% No data
5 0.817% No data
10 2.041% No data
15 3.893% No data
20 6.818% No data

Relationships between endpoints

Index endpoint: N14_FEMALE_GENITAL_DYSPLASIA_NOS – Dysplastic lesion of unknown severity in the cervix uteri, vagina or vulva

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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