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Guttate psoriasis

DOID EFO Endpoint Browser PheWeb

L12_PSORI_GUTTATE

psoriasis: An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.

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Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L40.4
  • Cause of death: ICD-10 — L40.4

2 out of 7 registries used, show all original rules.

607

4. Check minimum number of events

None

607

5. Include endpoints

None

607

6. Filter based on genotype QC (FinnGen only)

539

Control definitions (FinnGen only)

Control exclude
L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L40
Name in latin
Psoriasis guttata

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3699 2116 1568
Only index persons 3553 2064 1489
Unadjusted period prevalence (%)
Whole population 0.05 0.06 0.04
Only index persons 0.07 0.08 0.06
Median age at first event (years)
Whole population 41.77 41.62 41.86
Only index persons 41.40 41.48 41.29

-FinnGen-

Key figures

All Female Male
Number of individuals 539 334 205
Unadjusted period prevalence (%) 0.11 0.12 0.09
Median age at first event (years) 48.03 46.20 51.02

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
566
Matched controls
5660
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D05BB02
ATC
acitretin; oral
202.4
307.7
160
11
L40.4
ICD-10 Finland
Guttate psoriasis
4503599627370496.0
307.7
559
*
L40.0
ICD-10 Finland
Psoriasis vulgaris
971.8
307.7
400
14
D05AX52
ATC
calcipotriol, combinations; topical
202.0
307.7
395
64
D07XC01
ATC
betamethasone; topical
24.9
307.7
327
295
D05AX02
ATC
calcipotriol; topical
134.7
307.7
277
40
L40
ICD-10 Finland
Psoriasis
77.7
234.0
127
21
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
89.9
217.2
115
16
L04AX03
ATC
methotrexate; systemic
13.8
194.4
226
260
D07AC01
ATC
betamethasone; topical
13.1
174.8
455
1348
D07AD01
ATC
clobetasol; topical
9.1
150.7
263
491
E0000UV, ,
ATC
11.7
141.3
472
1698
E000001, ,
ATC
8.1
139.6
297
678
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
771.6
128.8
122
*
D05AX03
ATC
calcitriol; topical
258.4
123.1
122
6
D07AC13
ATC
mometasone; topical
6.5
111.1
335
1027
L40.9
ICD-10 Finland
Psoriasis, unspecified
174.0
109.7
112
8
D07AB08
ATC
desonide; topical
7.8
106.8
186
334
L40.5
ICD-10 Finland
Arthropathic psoriasis
1195.0
104.8
99
*
D07AB02
ATC
hydrocortisone butyrate; topical
5.7
93.5
332
1134
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
7.8
84.7
136
220
TQW80
NOMESCO Finland
Local dermatologic skincare
18.0
83.5
70
44
E000002, ,
ATC
6.2
78.9
170
369
E000003, ,
ATC
10.2
75.4
92
106
D02AE01
ATC
carbamide; topical
8.0
70.9
107
160
319
Kela drug reimbursment
Adalimumab, brodalumab, certolizumab pegol, etanercept, guselkumab, infliximab, ixekizumab, risankizumab, sekukinumab and ustekinumab (skin psoriasis)
+∞
64.9
61
*
S91
ICPC
Psoriasis
110.2
63.4
68
7
M07.3
ICD-10 Finland
Other psoriatic arthropathies
350.2
62.7
62
*
D02AX
ATC
Other emollients and protectives
11.7
61.5
66
63
L01BA01
ATC
methotrexate; systemic
12.5
58.7
60
53
L04AB04
ATC
adalimumab; parenteral
11.8
48.4
51
47
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
4.6
42.5
118
307
E000007, ,
ATC
5.7
40.6
83
166
D05AA
ATC
Tars
147.0
39.3
41
*
L40.8
ICD-10 Finland
Other psoriasis
147.0
39.3
41
*
XQ848
NOMESCO Finland
Dermatological photography
8.2
34.0
47
62
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
4.7
30.4
77
184
D09AB01
ATC
zinc bandage without supplements; topical
12.1
30.3
31
27
134
Kela drug reimbursment
General erythroderma
158.1
28.9
30
*
E000006, ,
ATC
4.6
28.2
72
173
69619
ICD-8 Finland
Psoriasis and similar disorders, Psoriasis alia sive NUD (vulgaris)
+∞
26.2
25
*
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
7.4
26.2
39
56
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
7.2
24.9
38
56
L04AC10
ATC
secukinumab; parenteral
94.4
24.9
27
*
L04AC18
ATC
risankizumab; parenteral
+∞
24.1
23
*
A07EC01
ATC
sulfasalazine; oral, rectal
3.9
22.7
72
203
377
Kela drug reimbursment
Apremilast and dimethyl fumarate (psoriasis)
+∞
22.0
21
*
L04AC05
ATC
ustekinumab; parenteral
40.4
21.9
27
7
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.6
21.2
167
796
M07.0*L40.5
ICD-10 Finland
Distal interphalangeal psoriatic arthropathy
+∞
21.0
20
*
6961A
ICD-9 Finland
Psoriasis and similar disorders, Other psoriasis[PSORIASIS VULGARIS]
+∞
21.0
20
*
L04AC13
ATC
ixekizumab; parenteral
114.3
20.7
22
*
L04AA32
ATC
apremilast; oral
+∞
18.9
18
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.4
18.2
156
766
H02AB06
ATC
prednisolone; systemic
2.2
18.0
298
1919
L04AD01
ATC
ciclosporin; systemic
13.1
17.3
30
24
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.6
16.5
58
175
L40.3
ICD-10 Finland
Pustulosis palmaris et plantaris
21.7
14.8
21
10
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.1
14.6
66
233
L04AC16
ATC
guselkumab; systemic
153.8
14.5
15
*
L04AA01
ATC
[U] ciclosporin
14.9
14.2
23
16
D07AA02
ATC
hydrocortisone; topical
2.4
13.8
112
531
J01FF01
ATC
clindamycin; systemic
2.1
13.0
172
992
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
12.2
265
1799
D07XB01
ATC
flumetasone; topical
21.9
12.1
17
8
L04AA13
ATC
[U] leflunomide
5.7
11.7
22
40
WQ066, ,
NOMESCO Finland
+∞
11.5
11
*
6960A
ICD-9 Finland
Psoriasis and similar disorders, Psoriatic arthropathy
+∞
11.5
11
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.5
10.7
73
319
A46
ICD-10 Finland
Erysipelas
2.3
10.3
86
411
L04AB01
ATC
etanercept; parenteral
8.7
10.1
21
25
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
9.8
255
1793
D07BC01
ATC
betamethasone and antiseptics; topical
2.4
9.6
71
321
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.8
9.6
49
185
L88
ICPC
Rheumatoid/seropositive arthritis
3.7
9.3
30
85
J01DB01
ATC
cefalexin; oral
2.1
9.3
479
4099
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.4
8.8
63
280
S29
ICPC
Skin symptom/complaint other
1.9
8.5
123
719
D07AB01
ATC
clobetasone; topical
3.7
8.2
26
73
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
8.1
80
408
WW200
NOMESCO Finland
Immunization
4.0
7.9
22
56
S18
ICPC
Laceration/cut
1.6
7.7
258
1909
RJ421, ,
NOMESCO Finland
25.4
7.6
10
*
RJ411, ,
NOMESCO Finland
13.6
7.4
12
9
M07.2*L40.5
ICD-10 Finland
Psoriatic spondylitis
+∞
7.3
7
*
L04AX01
ATC
azathioprine; systemic
3.1
7.1
29
96
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.5
7.1
43
177
E000004, ,
ATC
4.3
7.1
18
43
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.0
7.0
80
431
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.6
6.7
317
2519
WZC30
NOMESCO Finland
Teaching
1.9
6.7
96
558
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
6.5
177
1230
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
6.5
148
982
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
5.8
6.5
17
30
SPAT1263
SPAT
Sampling
1.6
6.5
226
1669
D05AX05
ATC
tazarotene; topical
70.6
6.4
7
*
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
2.6
6.3
35
138
L40.1
ICD-10 Finland
Generalized pustular psoriasis
+∞
6.3
6
*
M07.0
ICD-10 Finland
Distal interphalangeal psoriatic arthropathy
+∞
6.3
6
*
M073, L404,
ICD-10 Finland
+∞
6.3
6
*
T74.1
ICD-10 Finland
Physical abuse
3.7
6.2
19
52
N07BA03
ATC
varenicline; oral
2.6
6.2
35
139
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.3
6.2
45
202
Z3231
NOMESCO Finland
Registered nurse
1.7
6.1
147
987
K50.9
ICD-10 Finland
Crohn disease, unspecified
4.2
6.1
16
39
L04AB06
ATC
golimumab; parenteral
8.7
6.1
12
14

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
75
188
4.45
27.84
1.4
1.2
—
—
—
0
0
392
2553
2.74
27.08
13.2
5.8
0.59
0.56
e9/l
1.90
359
2216
287
1612
2.58
26.95
12.1
5.9
—
—
—
0
0
391
2561
2.70
26.38
13.2
5.8
0.04
0.04
e9/l
1.11
358
2221
367
2334
2.63
26.27
13.5
6.0
8.63
8.62
%
0.03
358
2208
364
2326
2.58
25.46
13.5
5.9
2.86
2.84
%
0.07
355
2195
398
2663
2.67
25.13
13.3
6.1
0.20
0.19
e9/l
0.66
368
2351
368
2375
2.57
25.02
12.8
5.8
57.35
57.04
%
0.23
361
2279
362
2324
2.55
24.80
13.7
6.0
0.72
0.70
%
0.33
353
2185
392
2616
2.62
24.67
13.3
5.9
1.91
1.98
e9/l
0.46
367
2337
370
2406
2.55
24.56
13.4
5.9
28.15
28.23
%
0.05
361
2300
406
2848
2.51
21.44
14.9
8.9
4.13
4.04
e9/l
0.36
369
2492
28
17
17.25
18.03
2.0
1.1
7.58
9.69
ug/l
1.30
28
17
157
777
2.41
18.01
1.3
1.4
339.20
487.03
titre
1.07
25
165
464
3694
2.42
14.92
11.3
7.7
78.52
77.55
u/l
0.15
442
3514
95
411
2.58
14.29
6.9
5.0
0.07
0.09
%
0.10
28
98
317
2206
1.99
14.29
17.4
10.4
0.00
0.00
e9/l
0.78
283
1789
92
402
2.54
13.53
6.7
4.7
0.11
0.16
%
0.24
28
108
93
425
2.42
12.37
6.7
4.6
0.93
1.06
%
0.18
29
132
87
406
2.35
11.00
6.6
4.5
0.76
0.59
%
0.22
25
120
92
458
2.20
9.94
1.5
1.5
—
—
—
0
0
102
551
2.04
8.87
1.9
1.6
—
—
—
0
0
244
1748
1.70
8.43
3.3
3.1
36.90
31.68
u/l
0.78
232
1663
247
1807
1.65
7.68
4.8
3.6
23.05
70.74
e6/l
2.76
174
1237
118
707
1.85
7.48
1.7
1.5
—
—
—
0
0
107
632
1.85
7.08
1.5
1.4
—
—
—
0
0
178
1221
1.67
6.97
2.7
2.5
335.35
338.87
umol/l
0.16
158
1105
15
20
7.67
6.94
2.6
1.6
20.47
34.27
%
—
10
15
187
1301
1.65
6.93
4.0
2.9
0.25
0.36
e6/l
0.57
142
939
213
1534
1.62
6.86
4.2
3.0
44.81
98.93
e6/l
0.56
165
1169
26
83
3.24
6.80
4.8
3.7
3.92
4.35
e9/l
0.50
26
83
268
2043
1.59
6.79
12.0
11.0
1.16
1.18
inr
0.29
218
1696
104
618
1.84
6.73
2.7
3.2
4.22
4.51
e9/l
0.30
96
554
284
2208
1.57
6.53
2.9
2.5
74.93
75.46
nmol/l
0.11
265
2016
177
1235
1.63
6.39
8.7
4.4
—
—
—
0
0
139
915
1.69
6.28
3.6
2.7
519.70
533.10
mosm/kgh2o
0.30
128
803
201
1457
1.59
6.16
9.3
5.7
—
—
—
0
0
49
230
2.24
6.08
1.3
1.9
1.50
7.11
iu/ml
—
5
51
289
2289
1.54
5.90
6.8
6.9
1.21
1.21
mmol/l
0.19
253
1976
150
1023
1.63
5.87
1.7
1.7
—
—
—
0
0
328
2676
1.54
5.80
4.7
3.5
0.00
0.58
estimate
0.51
84
525
51
249
2.15
5.76
1.1
1.1
—
—
—
0
0
375
3154
1.56
5.75
5.3
4.2
16.80
165.24
e6/l
—
5
50
82
475
1.85
5.73
2.7
2.9
1.79
1.86
%
0.31
76
431
314
2543
1.53
5.71
6.2
6.2
10.36
11.34
umol/l
0.94
296
2428
29
111
2.70
5.56
2.5
2.8
0.78
2.18
index
—
9
61
152
1054
1.60
5.52
3.6
2.5
5.55
6.41
e6/l
0.26
144
962
182
1321
1.56
5.42
1.7
1.6
19.85
20.17
nmol/l
0.11
166
1141
324
2660
1.51
5.39
4.7
3.5
15.91
0.00
estimate
0.49
89
556
258
2021
1.51
5.38
5.8
4.8
35.74
36.40
g/l
1.12
246
1924
150
1044
1.59
5.34
1.4
1.3
19.08
31.45
iu/ml
1.21
37
324
167
1193
1.57
5.32
4.8
4.1
—
—
—
0
0
114
743
1.67
5.28
2.9
2.5
174.25
104.48
ug/g
1.65
91
582
320
2632
1.50
5.20
4.8
3.5
0.00
0.00
estimate
0.50
90
549
254
1996
1.49
5.15
2.3
2.0
94.36
97.38
pmol/l
0.49
151
1064
95
600
1.70
4.93
6.4
7.2
103.33
104.23
mmol/l
0.80
95
600
170
1238
1.53
4.91
2.1
2.0
—
—
—
0
0
211
1613
1.49
4.82
4.6
3.4
6.89
8.01
mmol/l
3.09
181
1385
136
952
1.56
4.67
1.4
1.3
1.59
11.00
u/ml
4.80
57
380
73
435
1.78
4.65
1.9
2.3
0.22
0.22
g/l
0.04
66
411
526
4907
2.02
4.53
21.3
13.9
19.02
22.03
mg/l
1.53
450
3973
107
715
1.61
4.45
1.8
1.7
991.94
1202.38
nmol/l
1.78
87
552
102
681
1.61
4.26
2.5
2.0
—
—
—
0
0
192
1472
1.46
4.21
5.6
4.1
18.42
9.32
mg/mmol
0.57
132
907
32
628
0.48
4.09
1.4
1.4
—
—
—
0
0
164
1226
1.48
4.07
2.9
2.1
2.99
2.82
mg/l
0.43
146
1067
327
2775
1.42
4.06
5.2
4.9
6.55
6.55
mmol/l
0.01
312
2595
20
75
2.73
4.03
1.8
1.5
—
—
—
0
0
26
114
2.34
3.84
4.9
3.5
57.38
58.94
%
0.25
26
114
107
740
1.55
3.83
2.6
2.4
2.52
2.36
g/l
1.59
98
681
187
1452
1.43
3.76
4.5
3.6
0.00
0.00
estimate
0.80
84
521
260
2141
1.40
3.72
4.2
3.2
6.32
6.19
ph
1.12
146
1235
20
79
2.59
3.67
1.1
1.2
—
—
—
0
0
521
4894
1.81
3.66
21.0
15.9
3.96
3.95
mmol/l
0.13
509
4789
112
791
1.52
3.64
2.6
2.4
13.11
13.88
umol/l
0.46
104
733
251
2062
1.39
3.62
6.0
6.2
1.21
1.21
mmol/l
0.66
238
1898
520
4887
1.79
3.57
20.9
15.8
139.48
139.72
mmol/l
1.45
510
4799
104
726
1.53
3.56
3.4
2.8
2.81
2.59
e6/l
0.10
58
335
21
87
2.47
3.51
2.9
3.0
—
—
—
0
0
542
5169
2.15
3.45
28.9
17.4
74.21
74.67
umol/l
0.15
536
5116
184
1446
1.40
3.40
4.6
3.5
62.36
55.79
mg/l
0.10
135
929
487
4516
1.56
3.36
7.3
5.8
39.29
38.61
mmol/mol
0.78
461
4295
61
381
1.67
3.31
7.5
9.1
—
—
—
0
0
85
581
1.54
3.20
6.4
5.5
1.08
1.03
mmol/l
0.85
80
543
181
1434
1.39
3.15
2.2
2.0
173.66
221.72
u/l
0.33
173
1361
57
355
1.67
3.14
2.8
3.1
72.47
73.20
e9/l
0.06
47
261
43
248
1.79
3.09
3.2
2.5
0.69
0.63
%
0.62
43
248
64
413
1.62
3.07
4.7
3.4
1.87
1.87
mmol/l
0.00
59
354
62
397
1.63
3.07
3.1
2.4
0.33
0.41
e6/l
0.11
57
379
107
775
1.47
3.06
3.1
3.1
0.82
0.82
mmol/l
0.18
98
743
397
3568
1.38
3.02
4.2
3.2
55.30
43.67
u/l
1.70
373
3409
191
1538
1.37
2.98
3.4
2.5
52.58
62.14
u/l
1.40
176
1448
29
149
2.00
2.95
1.1
1.2
—
—
—
0
0
26
129
2.06
2.90
3.5
2.3
—
—
—
0
0
66
436
1.58
2.89
4.7
3.5
7.38
7.39
ph
0.40
40
243
32
172
1.91
2.87
3.2
3.7
258.55
304.62
mg/l
0.13
20
76
74
503
1.54
2.86
1.9
2.0
344.92
378.61
nmol/l
0.74
66
470
9
23
3.96
2.78
6.2
3.9
444.00
529.87
u/ml
—
9
23
42
249
1.74
2.78
1.9
2.1
0.00
0.01
estimate
0.49
15
91
68
459
1.55
2.72
3.1
2.4
25.64
141.68
u/l
0.55
59
377
93
671
1.46
2.71
2.7
2.5
22.40
23.67
%
0.35
83
628
9
24
3.79
2.68
1.0
1.1
1258.89
1710.88
miu/ml
—
9
24
45
275
1.69
2.68
1.4
1.2
—
—
—
0
0
17
73
2.37
2.67
2.1
1.2
—
—
—
0
0
21
100
2.14
2.62
2.2
1.5
5293.85
10955.04
e6/l
0.98
13
70
22
108
2.08
2.55
5.1
4.1
—
—
—
0
0
170
1373
1.34
2.55
3.5
2.7
—
—
—
0
0
13
51
2.59
2.46
3.2
2.8
104.46
105.33
mmol/l
0.22
13
51
13
51
2.59
2.46
3.2
2.8
4.28
4.00
mmol/l
0.76
13
51
170
1386
1.32
2.37
4.1
3.8
7.40
7.40
ph
0.05
122
970
91
671
1.42
2.37
1.3
1.2
—
—
—
0
0
487
4591
1.44
2.33
5.6
5.3
1.78
1.83
mu/l
0.45
455
4311
163
1330
1.32
2.24
1.3
1.3
1.05
1.79
u/ml
0.76
41
379
27
150
1.84
2.24
1.3
1.2
—
—
—
0
0
52
346
1.55
2.24
3.8
3.8
1.21
1.23
mmol/l
0.74
47
298
536
5164
1.72
2.22
21.3
10.9
29.19
26.91
u/l
1.33
529
5052
59
405
1.51
2.21
4.2
3.5
—
—
—
0
0
12
48
2.53
2.20
1.3
1.1
—
—
—
0
0
8
24
3.37
2.18
1.9
1.9
186.85
96.76
ng/l
—
8
24
490
4637
1.42
2.17
5.2
4.7
5.96
5.84
mmol/l
1.12
454
4333
45
292
1.59
2.16
4.1
3.3
7.41
7.42
ph
0.21
36
244
17
329
0.50
2.14
1.7
1.7
—
—
—
0
0
40
253
1.63
2.13
2.3
1.5
0.34
0.28
mg/l
0.33
24
108
111
864
1.35
2.10
3.8
3.8
654.63
451.04
ng/l
0.21
73
604
82
607
1.41
2.10
1.7
1.3
—
—
—
0
0
76
555
1.43
2.09
2.4
2.6
6.51
8.39
umol/l
0.74
66
488
20
104
1.96
2.03
2.4
2.4
292.16
111.31
ug/min
0.31
11
61
11
44
2.53
2.02
5.3
4.0
—
—
—
0
0
120
951
1.33
2.01
1.8
1.7
433.42
24242857.89
pmol/l
0.79
105
825
63
448
1.46
2.00
2.1
2.0
0.00
0.03
estimate
0.50
17
113
144
1174
1.30
1.97
1.7
1.7
1.11
1.08
mg/l
0.04
112
899
12
51
2.38
1.96
3.3
2.8
1.21
1.19
mmol/l
0.36
12
51
508
4857
1.45
1.94
5.9
4.8
4.67
4.68
mmol/l
0.10
476
4604
9
33
2.75
1.94
1.1
1.2
275.11
155.15
iu/ml
—
9
33
18
92
1.99
1.92
1.2
1.1
—
—
—
0
0
9
35
2.60
1.80
2.0
3.1
1960.33
842.09
mg
—
9
35
419
3908
1.28
1.79
4.5
4.4
14.59
14.62
pmol/l
0.06
388
3621
143
1179
1.28
1.79
2.4
2.2
—
—
—
0
0
236
2067
1.24
1.77
2.1
1.9
1.36
1.38
mmol/l
0.11
207
1794
42
283
1.52
1.75
3.9
3.0
130.31
130.47
g/l
0.02
42
276
231
2023
1.24
1.72
5.0
3.4
0.00
0.02
estimate
1.41
76
463
176
1496
1.26
1.71
4.5
3.0
0.16
0.07
estimate
0.29
74
443
483
4600
1.34
1.70
5.2
4.0
1.36
1.27
mmol/l
1.24
453
4322
67
502
1.38
1.62
6.4
9.1
7.39
7.42
ph
0.52
36
285
5
14
3.59
1.62
4.2
1.5
—
—
—
0
0
184
1582
1.24
1.61
2.6
2.3
—
—
—
0
0
7
26
2.71
1.58
1.1
1.2
—
—
—
0
0
67
505
1.37
1.57
6.3
9.0
13.51
12.33
kpa
0.56
62
488
67
505
1.37
1.57
6.4
9.0
5.10
5.14
kpa
0.12
62
486
549
5364
1.78
1.57
34.2
21.2
256.93
254.07
e9/l
0.46
540
5287
66
497
1.37
1.56
6.4
9.1
0.66
0.95
mmol/l
0.18
53
414
15
78
1.95
1.55
4.1
2.9
3.31
2.63
mmol/l
—
9
50
549
5367
1.76
1.52
34.1
21.1
4.49
4.54
e12/l
1.70
539
5282
31
203
1.56
1.49
3.5
2.6
—
—
—
0
0
549
5369
1.75
1.48
34.2
21.2
6.87
6.68
e9/l
1.55
539
5278
11
53
2.10
1.39
1.3
1.2
—
—
—
0
0
8
161
0.49
1.38
1.5
1.6
—
—
—
0
0
18
295
0.60
1.35
2.7
2.5
51.94
55.54
u/ml
0.03
18
285
19
113
1.71
1.33
1.1
1.1
5.13
1.72
u/ml
0.45
13
58
280
2549
1.19
1.32
3.8
3.1
106.44
108.28
ug/l
0.06
265
2407
508
4909
1.34
1.31
6.2
5.4
2.77
2.76
mmol/l
0.04
475
4644
203
1795
1.20
1.31
4.5
3.5
73.11
72.91
ng/l
0.00
136
1171
6
24
2.52
1.30
1.0
1.2
—
—
—
0
0
6
24
2.52
1.30
1.2
1.4
5.33
6.41
mmol/l
—
6
24
54
408
1.36
1.28
4.4
3.9
7.37
7.36
ph
0.71
38
292
8
157
0.50
1.26
1.5
1.5
—
—
—
0
0
6
25
2.41
1.24
1.0
1.1
—
—
—
0
0
6
25
2.41
1.24
1.5
4.9
14.72
17.48
%
—
6
25
8
36
2.24
1.24
1.4
1.2
—
—
—
0
0
10
50
2.02
1.17
1.7
2.2
30.80
33.06
pg
—
10
50
29
199
1.48
1.17
6.6
3.3
25.16
25.04
mmol/l
0.09
29
192
500
4836
1.29
1.16
5.5
4.7
1.45
1.46
mmol/l
0.25
469
4568
33
233
1.44
1.16
3.4
1.9
—
—
—
0
0
30
208
1.47
1.15
4.8
3.6
—
—
—
0
0
17
103
1.67
1.14
1.2
1.0
—
—
—
0
0
37
268
1.41
1.14
3.0
2.3
4008.29
3987.37
u/l
0.00
14
118
253
2307
1.17
1.12
2.8
2.7
—
—
estimate
—
0
0
183
1625
1.19
1.11
2.9
3.1
2.34
2.36
mmol/l
0.66
169
1497
15
242
0.61
1.09
1.3
1.1
0.87
0.90
g/l
0.21
15
242
30
211
1.45
1.08
1.1
1.5
—
15.07
—
0
7
15
90
1.68
1.05
1.1
1.5
—
—
—
0
0
5
22
2.28
1.03
1.4
1.8
0.83
0.84
nmol/l
—
5
17
9
48
1.89
1.01
1.1
2.4
—
—
—
0
0
37
275
1.37
1.00
3.2
1.9
—
—
—
0
0
15
236
0.63
1.00
1.2
1.1
1.41
1.54
g/l
1.73
15
236
220
1999
1.16
0.99
2.1
2.0
—
—
—
0
0
5
23
2.18
0.98
1.0
1.5
130.80
143.09
nmol/l
—
5
23
38
285
1.36
0.98
2.5
3.1
164.39
179.86
ng/l
0.07
31
254
7
36
1.96
0.97
1.4
1.2
—
—
—
0
0
7
36
1.96
0.97
2.9
2.1
49.89
39.23
%
—
7
36
136
1192
1.19
0.95
1.4
1.4
2.52
2.38
g/l
0.38
81
771
45
349
1.31
0.94
2.5
2.4
5.55
7.58
ug/l
0.72
36
313
39
297
1.34
0.92
1.5
2.2
—
—
—
0
0
30
220
1.38
0.89
6.2
3.1
1.02
1.02
ratio
0.14
30
211
39
299
1.33
0.88
3.1
1.9
—
—
—
0
0
6
30
2.01
0.87
4.8
1.6
—
—
—
0
0
8
46
1.75
0.83
2.3
1.8
85.29
90.09
%
—
8
46
6
32
1.88
0.82
1.0
1.0
—
—
—
0
0
25
181
1.40
0.81
1.2
1.2
—
—
—
0
0
17
114
1.51
0.80
1.1
1.2
311.45
203.85
u/ml
1.00
11
59
20
139
1.45
0.80
1.6
1.3
227.00
307.58
ug/g
1.01
14
76
56
458
1.25
0.80
1.2
1.2
—
—
—
0
0
14
90
1.57
0.79
1.1
1.0
1.33
2.46
u/ml
—
9
42
17
115
1.49
0.77
2.8
2.4
8.69
8.17
kpa
1.03
17
115
22
158
1.41
0.75
1.0
1.3
—
2.46
—
0
16
24
322
0.73
0.74
1.1
1.1
—
—
—
0
0
38
300
1.29
0.73
3.2
1.9
—
—
—
0
0
9
57
1.59
0.71
1.8
1.2
—
—
—
0
0
15
101
1.50
0.70
1.1
1.0
10.57
5.89
u/ml
—
10
54
140
1261
1.15
0.70
3.5
3.2
1704.60
1142.49
ng/l
0.34
118
1073
38
302
1.28
0.70
3.1
1.8
—
—
—
0
0
38
302
1.28
0.70
3.3
1.9
—
—
—
0
0
7
42
1.67
0.68
1.7
2.0
9.14
10.90
%
—
7
42
14
95
1.49
0.64
1.1
1.1
2.88
1.03
u/ml
—
9
38
349
3338
1.12
0.63
3.8
3.8
—
0.00
—
0
5
29
226
1.30
0.63
1.3
1.4
167.37
254.25
miu/ml
0.80
14
113
51
426
1.22
0.63
3.8
4.6
3.52
17.62
ug/l
0.79
40
349
20
147
1.37
0.62
1.4
2.1
1.94
4.68
iu/l
—
7
66
11
71
1.56
0.62
1.7
1.3
202.02
80.20
mu/l
0.35
11
66
40
326
1.24
0.61
5.1
3.7
114.54
81.42
ng/l
0.75
35
292
19
139
1.38
0.61
1.4
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.0
—
—
—
0
0
0
20
0.00
0.60
0.0
1.0
—
—
—
0
0
0
20
0.00
0.60
0.0
1.0
—
—
—
0
0
66
570
1.18
0.58
1.5
1.4
—
—
—
0
0
43
358
1.22
0.56
1.3
1.2
—
—
—
0
0
143
1555
0.89
0.55
1.7
1.5
—
—
—
0
0
16
116
1.39
0.55
1.3
1.1
—
—
—
0
0
6
38
1.58
0.54
2.0
1.1
—
—
—
0
0
72
631
1.16
0.54
1.2
1.2
—
—
—
0
0
40
332
1.22
0.54
1.3
1.3
36.83
24.55
iu/l
1.04
31
287
66
753
0.86
0.52
2.8
3.0
0.68
0.73
ug/l
0.20
43
447
25
197
1.28
0.52
2.2
1.8
—
—
—
0
0
28
225
1.26
0.50
1.1
1.2
—
2.53
—
0
11
6
41
1.47
0.50
1.0
1.2
—
—
—
0
0
7
45
1.56
0.49
1.0
1.0
—
—
—
0
0
67
757
0.87
0.47
1.6
1.5
—
—
—
0
0
7
47
1.50
0.47
2.6
1.2
—
—
—
0
0
7
48
1.46
0.47
1.6
1.2
—
—
—
0
0
5
85
0.58
0.45
3.2
1.6
—
—
—
0
0
7
50
1.40
0.45
1.0
2.4
—
—
—
0
0
26
211
1.24
0.44
1.3
1.3
—
—
—
0
0
7
51
1.38
0.44
1.0
1.3
—
—
—
0
0
11
78
1.42
0.43
1.1
1.1
1.13
7.54
u/ml
—
6
29
5
31
1.62
0.43
1.0
1.1
1.01
1.08
ratio
—
5
25
13
96
1.36
0.42
2.2
3.1
12.64
8.22
pmol/l
0.46
13
96
8
58
1.38
0.41
2.3
1.6
—
—
—
0
0
8
58
1.38
0.41
2.3
1.6
—
—
—
0
0
8
58
1.38
0.41
2.3
1.6
—
—
—
0
0
8
58
1.38
0.41
2.3
1.6
—
—
—
0
0
15
114
1.32
0.41
1.7
1.4
—
—
—
0
0
8
59
1.36
0.41
1.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
8
61
1.32
0.39
3.1
2.3
—
—
—
0
0
515
5084
1.14
0.38
18.6
12.4
—
—
—
0
0
9
68
1.33
0.37
1.0
1.3
—
94.34
—
0
5
9
68
1.33
0.37
1.9
2.2
—
—
—
0
0
6
45
1.34
0.34
1.3
1.2
—
1.77
u/ml
—
0
22
14
110
1.28
0.32
1.5
1.3
7.11
19.40
e6/l
—
9
84
17
208
0.81
0.31
1.5
1.6
59.49
58.45
ug/l
0.04
17
180
14
112
1.26
0.28
2.0
1.3
738.67
102.84
e6/l
—
9
89
13
161
0.80
0.27
4.5
2.6
—
—
—
0
0
126
1193
1.07
0.26
4.5
3.4
1.02
1.02
kg/l
0.70
93
785
56
611
0.91
0.26
1.6
1.8
—
—
—
0
0
205
2125
0.94
0.25
3.5
2.9
—
—
—
0
0
5
38
1.32
0.23
1.8
1.8
—
—
—
0
0
14
168
0.83
0.23
1.1
1.1
—
—
—
0
0
5
40
1.25
0.22
1.0
1.0
—
—
—
0
0
32
357
0.89
0.22
1.6
1.6
979.51
970.11
mu/l
0.02
32
303
5
41
1.22
0.22
1.4
1.2
147.68
186.85
pmol/l
—
5
41
5
42
1.19
0.21
1.0
1.1
142.80
107.57
pmol/l
—
5
42
5
42
1.19
0.21
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
1.72
—
0
11
0
10
0.00
0.21
0.0
2.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
7.58
—
0
12
8
104
0.77
0.21
1.0
1.1
33.85
13.23
au/ml
—
8
38
6
48
1.25
0.20
7.5
5.9
6.38
6.62
mmol/l
—
6
38
22
193
1.15
0.20
1.4
1.5
1.29
1.21
g/l
0.78
22
183
12
99
1.22
0.19
2.5
1.8
—
—
—
0
0
79
745
1.07
0.19
1.8
1.8
—
—
—
0
0
41
377
1.09
0.18
1.4
1.4
—
—
—
0
0
46
494
0.93
0.16
1.9
1.7
3.51
3.48
mmol/l
0.05
32
353
11
92
1.20
0.16
1.0
1.2
—
—
—
0
0
19
168
1.14
0.16
1.3
1.2
—
—
—
0
0
8
73
1.10
0.15
1.1
1.2
—
—
—
0
0
20
224
0.89
0.15
2.0
2.2
—
—
—
0
0
15
131
1.15
0.14
1.4
3.2
1.11
2.02
ratio
—
9
76
18
160
1.13
0.14
4.3
2.9
1.56
1.47
mg/l
0.18
18
144
18
201
0.89
0.13
1.4
1.8
—
—
—
0
0
39
417
0.93
0.13
1.1
1.3
76.52
158.14
u/ml
1.90
16
176
23
209
1.10
0.13
1.8
1.6
7.70
7.10
u/ml
0.07
11
52
5
46
1.09
0.09
1.6
1.5
35.28
32.87
g/l
—
5
41
13
145
0.89
0.09
2.6
7.7
—
—
—
0
0
16
145
1.11
0.09
2.0
1.8
154.38
229.42
pmol/l
2.66
16
139
5
48
1.04
0.09
1.0
1.2
—
—
—
0
0
6
56
1.07
0.08
2.7
2.1
9.50
10.19
mmol/l
—
6
56
7
67
1.05
0.08
1.1
1.3
—
—
—
0
0
93
910
1.03
0.06
2.8
2.6
2.46
2.44
mmol/l
0.42
88
823
426
4272
0.99
0.02
27.4
17.3
332.37
332.82
g/l
0.49
421
4257
14
146
0.96
0.00
1.1
1.1
—
—
—
0
0
11
106
1.04
0.00
1.1
1.3
—
—
—
0
0
13
126
1.03
0.00
1.0
1.1
—
—
—
0
0
13
126
1.03
0.00
1.0
1.1
—
—
—
0
0
40
401
1.00
0.00
3.2
2.0
6.18
6.14
ph
0.07
28
267
124
1241
1.00
0.00
5.0
5.0
1.53
2.03
ug/l
0.90
111
1118
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
5
54
0.93
0.00
1.2
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
0.16
—
0
5
6
59
1.02
-0.00
2.2
2.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
194.20
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
1.19
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
28.80
—
0
5
0
7
0.00
-0.00
0.0
3.6
—
48.86
—
0
7
0
5
0.00
-0.00
0.0
1.8
—
288.20
—
0
5
0
9
0.00
-0.00
0.0
10.2
—
4.80
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
18.60
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
16.74
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
7.92
—
0
8
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
68.00
—
0
8

Mortality – FinRegistry

↥

Association

Association between endpoint L12_PSORI_GUTTATE and mortality.

Females

Parameter HR [95% CI] p-value
L12_PSORI_GUTTATE 1.255 [1.02, 1.54] 0.032
Birth year 0.994 [0.99, 1.0] 0.2

During the follow-up period (1.1.1998 — 31.12.2019), 164 out of 1925 females with L12_PSORI_GUTTATE died.

Males

Parameter HR [95% CI] p-value
L12_PSORI_GUTTATE 1.695 [1.38, 2.08] < 0.001
Birth year 0.986 [0.98, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 209 out of 1420 males with L12_PSORI_GUTTATE died.

Mortality risk

Mortality risk for people of age

years, who have L12_PSORI_GUTTATE.

N-year risk Females Males
1 0.107% 0.352%
5 0.745% 1.989%
10 1.799% 4.954%
15 3.345% 9.073%
20 5.875% 14.936%

Relationships between endpoints

↥

Index endpoint: L12_PSORI_GUTTATE – Guttate psoriasis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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