Vitreous prolapse

H7_VITRPROLAPSE

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H43.0 Cause of death: ICD-10 — H43.0 2 out of 7 registries used, show all original rules.	125
4. Check minimum number of events None	125
5. Include endpoints None	125
6. Filter based on genotype QC (FinnGen only)	111

Control definitions (FinnGen only)

Control exclude: H7_VITREOUS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H43
Name in latin: Prolapsus corporis vitrei

NAME	H7_VITRPROLAPSE
CONTROL_EXCLUDE	H7_VITREOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H430
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H430
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Vitreous prolapse based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	559	343	212
Only index persons	534	334	200
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	63.03	63.47	62.46
Only index persons	62.75	63.45	61.58

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	111	78	33
Unadjusted period prevalence (%)	0.02	0.03	0.02
Median age at first event (years)	61.05	59.56	64.58

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
115: Matched controls
1150

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H43.0

ICD-10 Finland

Vitreous prolapse

+∞

163.9

115

H43.8

ICD-10 Finland

Other disorders of vitreous body

42.8

29.4

H43.1

ICD-10 Finland

Vitreous haemorrhage

+∞

20.4

CJB10

NOMESCO Finland

Laser discission of secondary cataract

5.6

10.0

H26.4

ICD-10 Finland

After-cataract

5.1

9.9

CKC12

NOMESCO Finland

Photocoagulation of retina

13.1

9.4

CKD65

NOMESCO Finland

Pars plana or pars plicata vitrectomy

18.1

8.8

H33.0

ICD-10 Finland

Retinal detachment with retinal break

14.5

8.1

H3603, E103,

ICD-10 Finland

48.3

7.8

Z96.1

ICD-10 Finland

Presence of intraocular lens

3.7

7.6

H43.3

ICD-10 Finland

Other vitreous opacities

85.4

7.5

S01ED51

ATC

timolol, combinations; ophthalmic

5.1

7.5

H33.3

ICD-10 Finland

Retinal breaks without detachment

8.9

7.4

CKD40

NOMESCO Finland

Endophotocoagulation of retina

24.2

6.8

S01ED01

ATC

timolol; ophthalmic

9.0

6.5

XCW99

NOMESCO Finland

Other investigative procedure of eye

3.8

6.2

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

2.7

6.0

250

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3026782) Osmolality of Urine

203

2.30

3.99

2.7

2.8

535.82

541.25

mosm/kgh2o

0.05

178

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

198

2.19

3.47

3.4

2.9

1.38

1.27

e6/l

0.08

102

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

174

2.16

3.14

3.7

3.1

2.51

2.93

e6/l

0.13

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

394

1.95

3.09

5.3

3.2

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

4.97

2.97

1.1

1.2

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

492

1.87

2.70

3.2

2.5

75.32

78.22

nmol/l

0.44

446

(3030467) Casts [#/volume] in Urine by Automated count

318

1.81

2.39

4.1

3.1

0.29

0.48

e6/l

0.59

226

(3024522) Salmonella sp identified in Specimen by Organism specific culture

5.75

2.23

1.4

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

5.75

2.23

1.4

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

5.75

2.23

1.4

—

(3021788) Differential panel - Synovial fluid

4.46

2.18

1.2

—

(1761868) Lipid panel - Serum or Plasma

419

1.71

2.12

3.6

3.4

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

5.17

2.09

1.4

—

(3005715) Vancomycin [Mass/volume] in Serum or Plasma

5.17

2.09

4.8

3.6

13.78

10.01

mg/l

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

5.17

2.09

1.4

—

(3000850) Epithelial cells [#/volume] in Urine

247

1.73

1.91

4.1

2.7

10.34

6.15

e6/l

0.37

228

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

2.01

1.78

1.4

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

161

1.79

1.72

6.7

7.3

104.54

103.73

mmol/l

0.40

161

(3024928) Oxygen saturation in Venous blood

2.70

1.69

2.0

3.1

66.71

52.34

—

(3021589) Normoblasts [#/volume] in Blood

495

1.60

1.69

12.4

11.9

0.00

0.01

e9/l

0.49

401

(1761482) Bacteria [#/volume] in Urine by Culture

2.91

1.68

3.3

4.2

—

(3026008) Bacteria identified in Urine by Culture

319

1.61

1.63

3.6

2.7

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

240

1.66

1.61

1.5

1.7

1.22

1.42

mg/l

0.11

194

(3014051) Protein [Presence] in Urine by Test strip

312

1.60

1.59

3.5

2.8

—

0.33

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

351

1.57

1.53

3.0

2.5

60.90

67.69

u/l

0.17

324

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.55

1.52

1.4

2.1

—

(3002582) Erythrocytes [#/volume] in Urine

372

1.55

1.47

5.3

3.2

23.91

35.06

e6/l

0.39

280

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.02

1.46

1.8

1.5

—

(42870588) Differential panel, method unspecified - Blood

354

1.55

1.46

6.8

5.5

—

(3012544) pH of Venous blood

120

1.81

1.46

7.7

4.0

7.39

0.03

(3000475) Leukocytes [#/volume] in Synovial fluid

3.03

1.37

1.2

1.4

41116.20

4030.83

e6/l

—

(4034850) Laboratory test

2.18

1.33

9.7

8.4

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

2.18

1.33

1.2

1.5

1.05

1.21

g/l

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.04

1.33

1.5

—

(3019230) Fractional oxyhemoglobin in Venous blood

2.58

1.32

2.2

2.0

63.67

47.87

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

201

1.59

1.27

1.4

1.5

—

(3018095) Leukocytes [#/volume] in Urine

413

1.47

1.21

6.4

3.8

87.36

100.93

e6/l

0.08

285

(3000991) Gas panel - Venous blood

103

1.76

1.21

10.6

9.1

—

(3000494) Fungus identified in Specimen by Culture

136

1.67

1.19

1.4

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

825

1.58

1.13

5.7

4.6

14.48

14.81

pmol/l

0.59

752

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.34

1.12

1.3

2.1

—

(3022096) Basophils/Leukocytes in Blood

515

1.44

1.12

8.7

5.7

0.75

0.69

0.35

484

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

225

1.52

1.11

3.3

3.7

37.04

367.76

ng/l

1.52

175

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.44

1.10

1.6

1.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

132

1.62

1.06

2.0

1.7

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

2.33

1.04

1.2

1.5

—

(3002030) Lymphocytes/Leukocytes in Blood

530

1.42

1.04

8.6

5.9

26.71

28.30

0.61

507

(40768797) Stomach Pathology biopsy report

167

1.55

1.03

1.5

1.2

—

(3019069) Monocytes/Leukocytes in Blood

521

1.41

1.02

8.7

5.9

8.68

0.00

495

(46235355) HIV 1 and 2 tests - Meaningful Use set

159

1.56

1.01

2.0

1.9

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.86

0.98

1.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

127

1.59

0.96

2.1

1.8

—

(3013115) Eosinophils [#/volume] in Blood

585

1.40

0.95

8.2

6.2

0.19

0.18

e9/l

0.05

514

(3018010) Neutrophils/Leukocytes in Blood

526

1.39

0.94

8.6

5.8

58.15

57.20

0.22

504

(3023520) Reticulocytes [#/volume] in Blood

103

1.64

0.93

2.3

3.1

61.44

73.08

e9/l

1.21

(3006504) Eosinophils/Leukocytes in Blood

517

1.38

0.93

8.7

5.8

2.56

2.82

0.39

489

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

848

1.51

0.92

9.3

8.5

78.33

80.74

u/l

0.24

804

(3006315) Basophils [#/volume] in Blood

567

1.38

0.92

8.3

6.2

0.04

e9/l

0.09

487

(3001604) Monocytes [#/volume] in Blood

567

1.38

0.92

8.3

6.1

0.56

e9/l

0.11

490

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

1.97

0.91

1.3

1.5

0.25

0.23

g/l

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.92

0.89

2.1

2.7

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

560

1.37

0.88

10.8

7.0

1.22

1.21

mmol/l

0.79

490

(3015736) pH of Urine

482

1.36

0.86

4.5

3.5

6.37

6.19

0.57

266

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.92

0.83

1.5

1.2

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

1.92

0.83

1.7

2.9

247.33

189.44

—

(3020682) Albumin/Creatinine [Ratio] in Urine

378

1.36

0.83

6.9

4.0

4.79

10.24

mg/mmol

1.18

234

(3019198) Lymphocytes [#/volume] in Blood

584

1.35

0.82

8.3

6.1

1.71

2.02

e9/l

1.00

517

(3001019) Free T4 and TSH panel - Serum or Plasma

1.72

0.80

2.1

1.6

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

107

1018

1.73

0.79

22.6

15.8

75.27

79.71

ml/min/173m2

1.29

101

952

(3028626) Oxygen [Partial pressure] in Capillary blood

2.13

0.75

4.2

1.8

8.60

8.08

kpa

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.85

0.74

1.1

1.7

—

(3007853) Bacteria identified in Skin by Aerobe culture

127

1.49

0.73

2.1

1.7

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

108

1030

1.80

0.72

6.7

5.4

4.72

4.69

mmol/l

0.09

100

963

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.66

0.71

9.1

4.1

24.65

24.36

mmol/l

0.16

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.52

0.70

1.0

2.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

329

1.33

0.70

3.9

3.1

0.00

estimate

—

101

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

623

1.32

0.70

5.1

6.9

10.50

10.80

umol/l

0.14

590

(3018418) pH of Serum or Plasma

358

1.32

0.69

10.9

4.4

7.39

7.40

0.51

248

(3013650) Neutrophils [#/volume] in Blood by Automated count

654

1.32

0.69

10.2

10.4

3.98

4.01

e9/l

0.04

574

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.63

0.68

3.5

2.5

0.66

0.63

0.11

(3015235) Bicarbonate [Moles/volume] in Capillary blood

1.82

0.67

6.6

2.6

24.58

26.24

mmol/l

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.82

0.67

1.2

2.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

506

1.30

0.66

3.2

2.7

—

estimate

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

175

1.39

0.65

2.0

1.8

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.61

0.65

3.5

2.5

1.02

1.22

0.54

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.76

0.64

1.6

1.1

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.68

0.63

2.5

2.4

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

1.70

0.62

1.4

1.1

—

0.53

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.58

0.61

1.6

1.5

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.61

0.0

1.1

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.61

0.0

1.2

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.61

0.0

1.5

—

1.36

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.61

0.0

1.2

—

(3025941) Bacteria identified in Stool by Culture

1.62

0.61

1.4

1.2

—

(40758558) Short blood count panel - Blood

364

1.29

0.60

5.0

6.3

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.60

0.0

1.0

—

(40761511) CBC panel - Blood by Automated count

110

1062

1.82

0.59

19.5

13.8

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

492

1.27

0.58

2.3

1.9

1.32

1.28

mmol/l

0.07

413

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

107

1025

1.63

0.58

6.6

5.3

1.52

1.53

mmol/l

0.04

952

(3000492) Spirometry study

1.47

0.57

1.2

1.6

—

(3009508) Creatinine [Moles/volume] in Urine

386

1.27

0.56

5.6

3.2

6.44

7.46

mmol/l

1.29

322

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.57

0.56

1.3

1.4

—

(3049717) Cytology report of Urine Cyto stain

1.66

0.56

2.0

3.4

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

103

984

1.45

0.52

5.3

4.5

1.28

1.27

mmol/l

0.04

909

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

108

1043

1.58

0.51

7.7

6.2

2.78

2.73

mmol/l

0.25

101

975

(3002256) Pathology report gross observation

146

1.36

0.51

1.4

1.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.49

0.50

5.4

2.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

183

1.32

0.50

2.0

1.5

—

(3003694) ABO and Rh group [Type] in Blood

286

1.27

0.49

1.3

1.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

599

1.24

0.49

4.8

3.7

0.00

estimate

-0.00

126

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

460

1.24

0.49

4.4

3.7

0.00

estimate

—

105

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.58

0.47

1.4

1.9

—

(40768804) Tissue Pathology biopsy report

452

1.23

0.47

2.6

2.1

—

(3035350) Ketones [Presence] in Urine by Test strip

602

1.23

0.46

4.8

3.8

0.00

12.40

estimate

0.50

131

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.46

0.43

1.1

1.4

39.70

27.95

iu/l

—

(4094501) Cardiovascular stress test using bicycle ergometer

1.64

0.43

1.4

1.1

—

(36660697) Celiac disease serology panel - Serum

105

1.38

0.43

1.4

1.2

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.59

0.43

1.4

1.3

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.59

0.43

1.8

1.6

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.4

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.41

0.0

1.3

—

91.67

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.41

0.0

1.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.4

—

(3026493) Urate [Moles/volume] in Serum or Plasma

292

1.23

0.41

4.8

2.9

384.28

333.25

umol/l

1.99

253

(3012516) Albumin [Mass/volume] in Urine

369

1.22

0.41

6.0

3.3

34.72

58.35

mg/l

0.73

232

(3019060) Gas panel - Arterial blood

1.36

0.41

3.2

4.4

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.36

0.41

2.1

1.2

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.41

0.0

1.6

—

948.62

—

(3045716) Anion gap in Serum or Plasma by calculation

0.00

0.40

0.0

2.1

—

10.39

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.40

0.0

1.3

—

(3023939) Sjogrens syndrome-A extractable nuclear Ab [Units/volume] in Serum

1.45

0.40

1.2

1.3

—

66.00

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

1.45

0.40

1.6

1.2

—

(44790047) Parainfluenza type 1 nucleic acid detection

0.00

0.39

0.0

1.6

—

(44790048) Parainfluenza type 2 nucleic acid detection

0.00

0.39

0.0

1.6

—

(44790049) Parainfluenza type 3 nucleic acid detection

0.00

0.39

0.0

1.6

—

(44806118) Parainfluenza type 4 nucleic acid detection

0.00

0.39

0.0

1.6

—

(4035726) Immunohistochemistry procedure

115

0.67

0.39

1.6

1.3

—

(3044640) Blood type and Crossmatch panel - Blood

343

1.21

0.38

3.2

2.3

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

511

1.19

0.36

13.4

6.4

1.23

1.21

mmol/l

0.82

477

(3036481) Cortisol [Moles/volume] in Serum or Plasma

109

1.32

0.35

2.0

2.4

316.21

375.70

nmol/l

0.64

102

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

482

1.18

0.35

2.4

2.0

99.49

97.51

pmol/l

0.08

243

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

642

1.19

0.35

3.4

2.7

—

(40768443) Skin Pathology biopsy report

1.35

0.34

1.3

1.2

—

(4024509) Urine culture

1.35

0.34

2.7

1.4

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

643

1.18

0.34

8.0

4.9

6.79

6.61

mmol/l

0.28

613

(3014007) Fractional oxyhemoglobin in Arterial blood

1.38

0.33

6.7

10.1

95.53

94.89

—

(3007164) IgA [Mass/volume] in Serum or Plasma

260

1.21

0.33

2.5

1.4

2.39

2.65

g/l

0.31

151

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

222

1.22

0.33

1.3

18.73

28.43

iu/ml

0.53

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

105

1019

1.35

0.33

6.1

5.3

5.99

5.94

mmol/l

0.16

947

(3042936) Bacteria identified in Isolate by Culture

166

1.25

0.32

3.9

2.0

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

102

1.31

0.31

1.6

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

102

1.31

0.31

2.9

2.3

0.20

0.21

g/l

0.15

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

205

1.22

0.30

1.3

26.64

5.84

u/ml

0.36

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

340

1.18

0.30

1.8

2.1

104.58

145.63

u/l

1.24

321

(3023368) Bacteria identified in Blood by Culture

292

1.18

0.29

7.8

4.3

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.24

0.29

1.0

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

102

992

1.25

0.25

9.2

6.4

39.89

39.43

mmol/mol

0.20

931

(3009261) Glucose [Presence] in Urine by Test strip

612

1.14

0.25

4.9

3.7

0.00

0.03

estimate

—

119

(3032080) INR in Blood by Coagulation assay

516

1.13

0.21

22.4

12.6

1.30

1.20

inr

0.63

424

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.2

—

(3011951) Aspergillus fumigatus IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.4

—

0.25

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.2

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.21

0.0

1.2

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.21

0.0

1.1

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.2

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.5

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.3

—

0.97

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.21

0.0

1.3

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.3

—

0.74

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.21

0.0

1.3

—

0.91

—

(4027681) Cerebrospinal fluid IgG ratio and IgG index

0.00

0.21

0.0

1.1

—

0.51

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.5

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

17.55

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

3.0

—

3.45

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

261

1.15

0.21

2.9

2.3

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

4.5

—

20.13

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.5

—

(3009595) Pneumocystis jirovecii DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

0.21

0.0

1.4

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.0

—

269.54

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.5

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.20

0.0

1.1

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.4

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.4

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.4

—

(3010726) Horse dander IgE Ab [Units/volume] in Serum

0.00

0.20

0.0

1.0

—

0.54

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.18

0.18

1.3

2.0

—

(3022145) Colonoscopy Study observation

148

1.17

0.18

1.5

1.4

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.16

0.18

2.1

3.3

431.29

213.89

ng/l

—

(3021960) Folate [Moles/volume] in Serum or Plasma

337

0.89

0.17

2.0

1.7

21.98

21.39

nmol/l

0.08

281

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

718

0.90

0.17

3.1

32.67

45.90

u/l

2.56

675

(21494755) Public health laboratory ask at order entry panel

1.22

0.16

1.3

—

(3019150) Specific gravity of Urine by Refractometry

259

1.11

0.13

4.8

4.0

1.02

kg/l

0.20

160

(3019977) pH of Arterial blood

125

1.14

0.10

5.5

8.0

7.41

7.42

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

1.06

0.08

3.6

2.4

9.26

14.38

nmol/l

—

(3029937) Albumin [Presence] in Urine by Test strip

346

0.94

0.08

4.8

4.0

0.00

estimate

-0.00

117

(40761536) Microorganisms panel - Urine sediment

0.88

0.07

3.6

3.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

264

0.93

0.07

10.0

5.9

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.12

0.06

1.5

1.3

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

978

1.09

0.06

7.4

5.7

1.81

1.92

mu/l

0.53

903

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

130

0.91

0.05

3.2

5.3

232.42

250.18

u/l

0.44

123

(3017143) Hepatitis C virus Ab [Presence] in Serum

119

0.92

0.04

3.1

1.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

134

1.05

0.00

2.5

1.6

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

344

1.03

0.00

4.5

3.4

2600.27

1125.10

ng/l

0.65

295

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

103

1029

1.01

0.00

24.9

15.8

23.33

23.19

mg/l

0.01

837

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

133

0.97

0.00

9.2

7.0

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

173

0.98

0.00

3.8

3.4

0.92

0.79

ug/l

—

118

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

287

1.01

0.00

1.5

1.3

0.80

1.31

u/ml

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

435

0.98

0.00

5.2

3.9

25.03

33.12

ng/l

0.59

299

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

226

1.02

0.00

5.3

5.1

22.47

21.44

0.18

126

(4198724) Urine methamphetamine measurement

0.00

0.0

1.2

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

2.8

—

308.00

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.7

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.3

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.3

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.8

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3029536) Hepatitis C virus RNA [Units/volume] (viral load) in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

4.78

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.4

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.9

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.3

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

1685.80

—

(3006576) Bicarbonate [Moles/volume] in Blood

0.00

0.0

7.2

—

25.06

—

(1002224) Polysomnography panel

0.92

0.00

1.0

1.1

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(3016038) Potassium [Moles/volume] in Urine

0.00

0.0

1.2

—

52.46

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

0.0

1.0

—

(3015183) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells

0.00

0.0

1.0

—

11.40

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.0

—

(3009876) Amylase isoenzyme 3 panel - Serum or Plasma

0.00

0.0

1.2

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.3

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.0

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

0.0

8.9

—

0.68

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.3

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.0

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

2.0

—

(3020891) Body temperature

0.89

-0.00

9.0

3.9

36.84

36.96

°c

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.3

—

70.00

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.88

-0.00

1.6

1.3

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

-0.00

0.0

1.4

—

207.39

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

110

1.00

-0.00

4.0

3.6

—

(3017181) Myelocytes/Leukocytes in Blood

100

1.00

-0.00

7.6

4.7

1.10

0.94

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

11.00

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.1

—

(3037534) Parathyrin related protein [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

51.94

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

-0.00

0.0

1.0

—

128.00

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

-0.00

0.0

1.5

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

-0.00

0.0

1.0

—

5.64

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.7

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

5.73

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

2.0

—

18.28

—

(3009343) pH of Capillary blood

1.02

-0.00

5.7

2.7

7.42

—

(40765096) Chromosome analysis panel by Banding

0.00

-0.00

0.0

1.0

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_VITRPROLAPSE and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_VITRPROLAPSE	1.037 [0.8, 1.35]	0.788
Birth year	0.997 [0.99, 1.01]	0.478

During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 299 females with H7_VITRPROLAPSE died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_VITRPROLAPSE.

N-year risk	Females	Males
1	0.133%	No data
5	0.737%	No data
10	1.708%	No data
15	3.248%	No data
20	5.587%	No data

Relationships between endpoints

↥

Index endpoint: H7_VITRPROLAPSE – Vitreous prolapse

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Vitreous prolapse

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints