Enteropathogenic Escherichia coli infection

ENTEROPATH_E_COLI

dysentery: Acute inflammation of the intestine associated with infectious diarrhea of various etiologies, generally acquired by eating contaminated food containing toxins, biological derived from bacteria or other microorganisms. Dysentery is characterized initially by watery feces then by bloody mucoid stools. It is often associated with abdominal pain; fever; and dehydration.

Suggest a new description

Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A04.0 Cause of death: ICD-10 — A04.0 2 out of 7 registries used, show all original rules.	145
4. Check minimum number of events None	145
5. Include endpoints None	145
6. Filter based on genotype QC (FinnGen only)	124

Control definitions (FinnGen only)

Control exclude: IBD_BACT_INTEST_INFECTIONS

Extra metadata

First used in FinnGen datafreeze: DF2
Parent code in ICD-10: A04
Name in latin: Infectio ab Escherichia coli enteropathogenica

NAME	ENTEROPATH_E_COLI
CONTROL_EXCLUDE	IBD_BACT_INTEST_INFECTIONS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A040
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A040
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Enteropathogenic Escherichia coli infection based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	847	440	403
Only index persons	730	388	342
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	59.41	61.54	56.93
Only index persons	58.07	59.97	55.91

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	124	59	65
Unadjusted period prevalence (%)	0.03	0.02	0.03
Median age at first event (years)	63.46	60.16	66.47

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
130: Matched controls
1300

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

A04.0

ICD-10 Finland

Enteropathogenic Escherichia coli infection

+∞

187.8

130

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

6.9

26.7

152

A04.7

ICD-10 Finland

Enterocolitis due to Clostridium difficile

168.1

14.8

A49.9

ICD-10 Finland

Bacterial infection, unspecified

5.0

13.2

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

4.5

12.2

106

R50.9

ICD-10 Finland

Fever, unspecified

4.1

12.1

145

A04.5

ICD-10 Finland

Campylobacter enteritis

+∞

11.6

J01MA02

ATC

ciprofloxacin; systemic

3.5

11.4

347

ZXD05

NOMESCO Finland

Urgent procedure

2.9

8.0

253

J18.9

ICD-10 Finland

Pneumonia, unspecified

3.0

8.0

225

TPH04

NOMESCO Finland

Cathetrisation of vein

3.1

7.8

186

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

4.8

7.8

A04AA01

ATC

ondansetron; systemic, rectal

4.5

7.5

JN3AA

NOMESCO Finland

Abdominal X-ray examination without contrast

8.3

7.1

UJF45

NOMESCO Finland

Flexible sigmoidoscopy with biopsy

4.0

6.6

A06AC01

ATC

ispaghula (psylla seeds); oral

2.8

6.6

202

P01AB01

ATC

metronidazole; oral, rectal

2.6

6.5

315

Z2221

NOMESCO Finland

Medical doctor

2.7

6.5

239

UJF30

NOMESCO Finland

Ileoscopy through colon

3.6

6.4

N17.9

ICD-10 Finland

Acute renal failure, unspecified

7.3

6.2

TPH20

NOMESCO Finland

Insertion of central venous catheter through subclavian or brachiocephalic vein

9.3

6.2

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

8.87

29.60

2.8

1.6

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

11.66

26.75

1.5

1.2

—

(3023368) Bacteria identified in Blood by Culture

326

4.07

14.18

7.8

4.5

—

(3002032) Base excess in Venous blood by calculation

131

4.26

12.44

5.4

6.1

1.75

1.80

mmol/l

0.03

110

(3012544) pH of Venous blood

133

4.19

12.17

5.7

6.1

7.37

7.39

0.97

(3048689) Calprotectin [Mass/mass] in Stool

153

3.97

11.77

3.9

2.6

289.57

97.89

ug/g

2.34

119

(3000991) Gas panel - Venous blood

112

4.22

11.32

10.3

10.0

—

(3003327) Ova and parasites identified in Stool by Light microscopy

6.07

11.00

2.2

1.3

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

4.34

10.09

4.8

7.3

23.38

24.29

mmol/l

0.72

(3018095) Leukocytes [#/volume] in Urine

437

3.26

9.79

7.0

4.4

18.34

60.73

e6/l

1.25

305

(3001604) Monocytes [#/volume] in Blood

606

3.66

9.61

12.3

7.3

0.62

0.58

e9/l

0.67

510

(3006315) Basophils [#/volume] in Blood

608

3.63

9.52

12.3

7.3

0.04

e9/l

0.14

511

(3002582) Erythrocytes [#/volume] in Urine

394

3.14

9.37

5.6

3.6

14.21

210.91

e6/l

0.62

295

(3019198) Lymphocytes [#/volume] in Blood

620

3.50

8.96

12.5

7.3

2.07

1.88

e9/l

0.38

541

(3025941) Bacteria identified in Stool by Culture

4.60

8.77

1.4

1.1

—

(3013115) Eosinophils [#/volume] in Blood

621

3.35

8.47

12.9

7.7

0.22

0.19

e9/l

0.54

533

(3018418) pH of Serum or Plasma

359

2.87

8.09

8.5

4.1

7.39

7.40

0.42

255

(3026782) Osmolality of Urine

229

2.92

7.68

2.7

3.0

518.29

544.76

mosm/kgh2o

0.37

199

(3013650) Neutrophils [#/volume] in Blood by Automated count

100

668

3.15

7.36

23.5

11.2

4.80

4.14

e9/l

0.36

579

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

156

3.03

7.02

2.8

1.8

—

(3021589) Normoblasts [#/volume] in Blood

550

2.76

6.92

16.1

13.1

0.00

e9/l

0.71

442

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

206

2.81

6.80

4.6

3.4

0.87

0.90

e6/l

0.03

109

(3014576) Chloride [Moles/volume] in Serum or Plasma

168

2.89

6.57

11.8

7.9

103.33

103.89

mmol/l

0.31

168

(3023520) Reticulocytes [#/volume] in Blood

106

3.23

6.48

3.5

4.7

62.99

68.15

e9/l

0.31

(3015377) Calcium [Moles/volume] in Serum or Plasma

383

2.55

6.40

6.8

3.6

2.33

2.35

mmol/l

0.51

348

(3030467) Casts [#/volume] in Urine by Automated count

344

2.53

6.28

5.0

3.5

0.24

0.31

e6/l

0.30

249

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

153

2.87

6.19

2.9

1.9

—

(40758558) Short blood count panel - Blood

358

2.47

6.00

15.7

7.5

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

575

2.55

5.92

14.5

8.0

1.20

1.21

mmol/l

0.90

498

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

3.49

5.64

6.1

4.6

1.08

1.36

0.62

(3007164) IgA [Mass/volume] in Serum or Plasma

248

2.48

5.53

1.6

2.18

2.36

g/l

0.23

146

(3013139) Helicobacter pylori Ag [Presence] in Stool

3.45

5.33

1.3

1.2

—

(3015736) pH of Urine

478

2.34

5.32

6.6

3.8

6.47

6.25

0.87

260

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

186

2.57

5.29

4.8

3.6

1.32

2.70

e6/l

0.70

(3021879) Hepatitis B virus core Ab [Presence] in Serum

3.05

5.28

1.6

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

3.40

5.21

6.2

4.7

0.74

0.63

0.71

(3021601) Nitrite [Presence] in Urine by Test strip

596

2.39

5.16

7.1

3.9

0.00

estimate

-0.00

130

(3035350) Ketones [Presence] in Urine by Test strip

605

2.32

4.85

7.1

4.0

0.00

12.40

estimate

0.50

131

(3004716) Salmonella sp identified in Stool by Organism specific culture

3.47

4.68

1.8

1.2

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

380

2.21

4.66

8.8

3.2

30.65

32.71

u/l

0.29

359

(3009261) Glucose [Presence] in Urine by Test strip

611

2.28

4.65

7.3

4.0

0.00

estimate

-0.00

123

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

4.77

4.60

2.4

1.6

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

4.44

4.58

1.5

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

4.44

4.58

1.5

1.1

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

4.44

4.58

1.6

1.1

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

108

2.76

4.58

3.7

2.9

0.20

0.22

g/l

0.87

101

(3031040) Bacteria [#/volume] in Urine by Automated count

730

2.39

4.46

9.3

4.7

37.11

340.36

e6/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

216

2.31

4.39

3.2

1.9

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.28

4.31

2.1

1.3

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

5.36

4.11

3.6

7.2

—

4982.00

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

5.92

4.06

1.4

1.6

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

5.92

4.06

1.4

1.6

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

10.47

4.06

1.4

1.0

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

10.47

4.06

1.3

1.0

—

(42870588) Differential panel, method unspecified - Blood

405

2.08

4.04

10.8

7.5

—

(3003396) Base excess in Arterial blood by calculation

136

2.46

3.99

10.9

8.0

0.93

0.85

mmol/l

0.03

116

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

488

2.07

3.98

2.1

2.2

100.73

93.02

pmol/l

0.78

259

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

2.74

3.97

7.2

5.0

103.20

81.62

ng/l

0.30

(3019977) pH of Arterial blood

138

2.42

3.87

10.9

7.9

7.43

7.41

0.66

(46235355) HIV 1 and 2 tests - Meaningful Use set

228

2.17

3.80

1.8

2.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

140

2.38

3.74

2.1

1.8

—

(3019150) Specific gravity of Urine by Refractometry

261

2.11

3.74

8.3

4.1

1.02

kg/l

0.44

164

(3032773) Endomysium IgG Ab [Titer] in Serum

7.02

3.73

1.0

—

(3026008) Bacteria identified in Urine by Culture

345

2.03

3.70

4.6

2.9

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

3.06

3.67

1.6

1.5

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

4.35

3.48

1.2

1.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

276

2.03

3.45

2.8

2.3

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.63

3.43

13.1

9.5

91.96

92.83

0.13

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

3.68

3.43

1.2

1.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

146

2.27

3.39

1.6

1.7

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.74

3.38

1.8

1.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

454

1.92

3.31

7.2

3.7

0.15

0.01

estimate

0.44

110

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

281

1.99

3.26

1.6

1.3

1.00

1.43

u/ml

0.27

(3044640) Blood type and Crossmatch panel - Blood

369

1.91

3.16

3.9

2.4

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.54

3.09

13.7

12.1

25.18

24.68

mmol/l

0.22

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

675

1.94

3.08

4.1

3.2

—

(3019060) Gas panel - Arterial blood

2.59

3.05

4.4

3.9

—

(3022145) Colonoscopy Study observation

117

2.29

3.01

1.8

1.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

265

1.93

2.93

9.6

5.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

525

1.83

2.88

3.8

2.8

—

estimate

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

127

2.20

2.84

2.5

1.9

379.92

382.41

nmol/l

0.02

118

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

8.60

2.77

2.4

2.2

0.62

0.61

mmol/l

—

(3044941) Cell count panel - Synovial fluid

4.19

2.61

1.4

1.1

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

3.99

2.50

1.0

—

(3024928) Oxygen saturation in Venous blood

3.50

2.44

2.1

8.1

49.88

61.27

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

190

1.91

2.39

1.7

1.8

—

(21494890) Protein electrophoresis panel - 24 hour Urine

4.78

2.30

1.7

1.4

—

(3000093) Morphology [Interpretation] in Blood Narrative

4.05

2.28

1.0

1.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.21

2.24

4.0

1.7

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.92

2.19

2.0

1.4

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

4.44

2.17

1.0

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

3.34

2.13

1.4

1.6

—

(3037756) Immunofixation for Serum or Plasma

3.04

2.12

1.7

1.3

—

(3012441) Differential panel - Pleural fluid

5.15

2.09

1.0

1.5

—

(40761535) Cells panel - Urine sediment

2.10

1.90

5.8

3.3

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

213

1.74

1.87

1.8

1.7

471.29

462.50

pmol/l

0.03

180

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

222

1.72

1.85

5.9

3.7

227.75

310.19

ng/l

0.13

175

(3017817) Protein [Mass] in Urine collected for unspecified duration

4.29

1.84

1.6

1.4

1355.20

454.08

—

(3016244) Insulin [Units/volume] in Serum or Plasma

4.29

1.84

1.6

1.9

3.54

9.44

mu/l

—

(3029937) Albumin [Presence] in Urine by Test strip

337

1.62

1.79

9.0

3.9

0.00

estimate

-0.00

120

(3015235) Bicarbonate [Moles/volume] in Capillary blood

2.61

1.78

6.8

2.4

23.79

24.72

mmol/l

—

(3000475) Leukocytes [#/volume] in Synovial fluid

2.77

1.75

1.9

1.4

11255.63

9412.32

e6/l

—

(21494815) CD4 cells/Lymphocytes in Specimen

3.95

1.73

4.0

3.7

26.92

42.64

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

2.26

1.67

3.1

1.9

0.36

5.44

ug/l

0.52

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

264

1.62

1.63

1.6

1.9

1.05

1.21

mg/l

0.22

214

(3022621) pH of Urine by Test strip

1.95

1.60

2.6

1.9

5.77

6.03

0.16

(3021788) Differential panel - Synovial fluid

3.09

1.60

2.0

1.3

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.68

1.54

1.0

1.4

—

(3035637) Corticotropin [Mass/volume] in Plasma

3.42

1.54

1.0

1.5

23.40

40.20

ng/l

—

(46236952) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)/1.73 sq M

1.91

1.52

5.0

2.7

53.22

63.32

ml/min/173m2

—

(3047169) Lambda light chains.free [Mass/volume] in Serum or Plasma

2.47

1.49

9.3

4.4

44.41

25.54

mg/l

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

435

1.50

1.45

5.9

4.0

32.04

38.45

ng/l

0.28

324

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

3.21

1.45

1.4

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.49

1.41

1.3

1.2

—

(40768797) Stomach Pathology biopsy report

146

1.70

1.38

1.3

1.2

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

1.37

0.0

1.2

—

1.57

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

1.37

0.0

1.2

—

0.52

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.44

1.31

1.5

1.4

—

(3032080) INR in Blood by Coagulation assay

541

1.45

1.26

16.5

14.8

1.21

1.28

inr

0.55

452

(3044290) Cell count panel - Cerebral spinal fluid

2.69

1.22

1.0

2.8

—

(3034860) Kappa light chains.free [Mass/volume] in Serum

2.18

1.21

10.4

4.4

114.19

200.56

mg/l

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

2.33

1.12

1.3

1.2

—

4.14

—

(3000494) Fungus identified in Specimen by Culture

138

1.62

1.11

1.7

1.5

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

2.43

1.10

1.6

—

(3023419) Bacteria identified in Sputum by Culture

2.43

1.10

3.2

2.8

—

(3005719) IgG [Mass/volume] in Serum or Plasma

1.75

1.09

3.9

2.9

10.31

9.83

g/l

0.18

(3025159) Blasts/Leukocytes in Blood

106

1.69

1.09

4.9

6.0

0.00

0.37

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

110

1009

1.59

1.08

40.3

16.0

78.36

81.14

ml/min/173m2

0.60

103

926

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

2.18

1.07

1.3

1.2

—

(3019225) pH of Specimen

108

0.44

1.06

9.0

4.0

7.39

7.36

—

(3000492) Spirometry study

100

1.68

1.02

1.7

1.6

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.06

1.01

1.0

1.4

—

(3017181) Myelocytes/Leukocytes in Blood

109

1.64

0.99

4.7

5.5

0.75

0.70

—

(40768793) Breast Pathology biopsy report

0.00

0.99

0.0

1.3

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

115

1072

1.63

0.97

48.5

16.9

30.80

23.94

mg/l

1.26

105

902

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

2.20

0.93

1.5

1.7

—

(4024509) Urine culture

1.96

0.90

2.6

2.0

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.05

0.88

1.3

2.5

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

106

982

1.43

0.81

6.1

5.5

1.79

1.90

mu/l

0.51

100

889

(3041096) Erythrocytes [Presence] in Urine by Automated

331

1.35

0.79

5.8

3.2

0.00

estimate

—

103

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

230

1.40

0.79

2.0

1.7

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

1.80

0.77

2.0

1.3

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

2.22

0.77

1.0

1.4

—

(40768804) Tissue Pathology biopsy report

428

1.32

0.76

2.2

2.1

—

(44790049) Parainfluenza type 3 nucleic acid detection

2.13

0.75

1.8

1.5

—

(44806118) Parainfluenza type 4 nucleic acid detection

2.13

0.75

1.8

1.5

—

(1616796) Gas panel - Central venous blood

2.13

0.75

2.4

2.3

—

(44790047) Parainfluenza type 1 nucleic acid detection

2.13

0.75

1.8

1.5

—

(44790048) Parainfluenza type 2 nucleic acid detection

2.13

0.75

1.8

1.5

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.89

0.75

1.0

1.6

—

(3023511) Choriogonadotropin [Units/volume] in Urine

2.04

0.73

1.2

1.0

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.59

0.71

1.2

1.0

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

1.96

0.71

1.0

2.2

—

(3022313) Gas panel - Capillary blood

1.65

0.71

3.9

4.2

—

(3020682) Albumin/Creatinine [Ratio] in Urine

384

1.31

0.70

3.9

4.0

11.98

11.44

mg/mmol

0.04

250

(3021901) Oxygen saturation in Capillary blood

1.88

0.69

6.0

2.1

89.94

91.49

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

129

1.46

0.68

1.8

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

1.62

0.66

6.0

5.5

1.03

0.89

—

(3002179) Metamyelocytes/Leukocytes in Blood

104

1.50

0.66

4.6

5.5

0.40

0.58

—

(3019309) Folate [Moles/volume] in Red Blood Cells

192

1.37

0.66

1.6

1.7

1229.39

1210.49

nmol/l

0.04

153

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

1.75

0.64

2.0

1.6

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.67

0.63

1.6

1.8

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

131

1.43

0.63

1.5

2.2

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

1.64

0.62

4.9

5.1

2.31

1.58

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.57

0.61

1.9

2.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

141

1.41

0.60

1.8

2.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

133

1.41

0.59

1.4

1.7

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.70

0.57

1.0

1.1

—

5.94

—

(3042936) Bacteria identified in Isolate by Culture

190

1.32

0.53

2.5

1.9

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

332

1.25

0.50

3.7

4.6

24.23

21.64

0.25

158

(3003694) ABO and Rh group [Type] in Blood

332

1.25

0.50

1.4

1.5

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

184

1.30

0.47

1.3

5.71

6.05

u/ml

—

(3017732) Neutrophils [#/volume] in Blood

148

1.33

0.47

12.3

2.9

3.66

4.43

e9/l

0.59

127

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

140

1.33

0.45

1.8

1.9

1.39

1.49

0.33

121

(3012516) Albumin [Mass/volume] in Urine

375

1.22

0.44

4.1

3.3

62.12

71.46

mg/l

0.14

254

(36660697) Celiac disease serology panel - Serum

1.39

0.43

1.1

1.2

—

(4034850) Laboratory test

1.64

0.43

7.0

16.9

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.41

0.0

2.5

—

(3025149) Bordetella pertussis IgA Ab [Units/volume] in Serum

0.00

0.41

0.0

1.0

—

4.62

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.41

0.0

3.1

—

16.37

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.33

0.40

1.4

1.6

1179.86

771.20

mu/l

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.33

0.40

1.1

2.5

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.40

0.0

3.5

—

107.87

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.40

0.0

1.2

—

(3010421) pH of Blood

1.45

0.39

2.2

2.9

7.41

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.41

0.35

1.8

1.5

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.38

0.35

1.8

1.5

—

(3049717) Cytology report of Urine Cyto stain

1.29

0.32

1.3

3.3

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

109

0.72

0.30

2.0

1.7

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

244

1.19

0.29

2.2

3.1

0.87

0.72

ug/l

0.31

154

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.32

0.27

1.5

2.5

—

(4035726) Immunohistochemistry procedure

105

1.26

0.26

1.5

1.4

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.37

0.24

2.8

1.7

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.29

0.23

1.8

1.6

—

(3008898) HLA-B27 [Presence]

1.20

0.21

1.2

1.1

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(3025547) Thyroglobulin Ab [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(4062490) Immunoglobulin typing, IgG

0.00

0.21

0.0

1.3

—

(4146454) Self-monitoring of blood glucose

0.00

0.21

0.0

4.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.21

0.0

1.0

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.2

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

1.24

0.20

1.2

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.20

0.0

1.1

—

(4268621) Lupus anticoagulant assay

0.00

0.20

0.0

2.0

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.20

0.0

1.1

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.18

0.19

3.2

3.1

—

(1761868) Lipid panel - Serum or Plasma

398

0.90

0.17

4.7

3.3

—

(21494755) Public health laboratory ask at order entry panel

1.13

0.16

1.3

1.5

—

(3009508) Creatinine [Moles/volume] in Urine

414

1.09

0.15

5.1

3.6

7.86

8.03

mmol/l

0.08

343

(3021440) Promyelocytes/Leukocytes in Blood

103

1.18

0.14

6.0

5.7

0.00

0.03

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

124

1.14

0.12

4.9

3.3

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

202

1.11

0.11

1.4

1.3

48.73

30.80

iu/ml

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

103

1048

0.92

0.10

6.5

6.0

2.55

2.60

mmol/l

0.19

974

(3002256) Pathology report gross observation

145

0.89

0.10

1.2

1.3

—

(40761511) CBC panel - Blood by Automated count

111

1094

1.10

0.09

32.9

15.0

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.07

0.09

4.0

2.4

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

120

0.91

0.05

1.5

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

133

1.06

0.01

23.6

8.6

—

(3048518) aPTT.lupus sensitive actual/normal (normalized LA screen)

0.00

-0.00

0.0

1.0

—

1.07

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

9.9

—

17.51

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

0.95

-0.00

1.2

—

31.00

—

(3011436) Histone Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.4

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

2.8

—

114.00

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

27.18

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3004451) EKG impression Narrative

0.00

-0.00

0.0

1.2

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.1

—

(40760109) Toxoplasma gondii IgG Ab avidity [Ratio] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

130

1.00

-0.00

1.5

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

-0.00

0.0

1.0

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

1.6

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

-0.00

0.0

1.0

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.1

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.3

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

-0.00

0.0

1.4

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

-0.00

0.0

1.0

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.4

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.3

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

11.17

—

(44813793) Dust mix specific IgE antibody measurement

0.00

-0.00

0.0

1.0

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.4

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

(40761536) Microorganisms panel - Urine sediment

1.00

-0.00

5.6

3.5

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

35.48

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.8

—

2.21

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3019897) Erythrocyte [DistWidth] in Red Blood Cells by Automated count

0.00

-0.00

0.0

2.1

—

13.59

—

(3015183) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells

0.00

-0.00

0.0

1.4

—

13.71

—

(3015024) Glucose [Moles/volume] in Serum or Plasma --1 hour post dose glucose

0.00

-0.00

0.0

1.8

—

6.95

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

-0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

98.68

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.0

—

131.00

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

-0.00

0.0

1.7

—

17.58

—

Mortality – FinRegistry

↥

Association

Association between endpoint ENTEROPATH_E_COLI and mortality.

Females

Parameter	HR [95% CI]	p-value
ENTEROPATH_E_COLI	2.339 [1.61, 3.41]	< 0.001
Birth year	1.0 [0.99, 1.01]	0.938

During the follow-up period (1.1.1998 — 31.12.2019), 122 out of 367 females with ENTEROPATH_E_COLI died.

Males

Parameter	HR [95% CI]	p-value
ENTEROPATH_E_COLI	2.601 [1.56, 4.34]	< 0.001
Birth year	0.982 [0.97, 0.99]	< 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 95 out of 334 males with ENTEROPATH_E_COLI died.

Mortality risk

Mortality risk for people of age

years, who have ENTEROPATH_E_COLI.

N-year risk	Females	Males
1	0.256%	0.401%
5	1.533%	2.463%
10	3.763%	6.297%
15	7.396%	12.017%
20	12.958%	19.635%

Relationships between endpoints

↥

Index endpoint: ENTEROPATH_E_COLI – Enteropathogenic Escherichia coli infection

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Enteropathogenic Escherichia coli infection

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints