systemic scleroderma: A chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. The two types of systemic scleroderma, limited cutaneous and diffuse cutaneous are classified with focus on the extent of affected skin. A relationship exists between the extent of skin area affected and degree of internal organ/system involvement. Systemic scleroderma can manifest itself in pulmonary fibrosis, Raynaud's syndrome, digestive system telangiectasias, renal hypertension and/or pulmonary hypertension.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
993 |
4. Check minimum number of eventsNone |
993 |
5. Include endpointsNone |
993 |
6. Filter based on genotype QC (FinnGen only) |
904 |
Control definitions (FinnGen only)
- Control exclude
- M13_SYSTCONNECT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M30-M36
- Name in latin
- Sclerosis systemica
Similar endpoints
↥List of similar endpoints to
Systemic sclerosis
based on the number of shared cases.
Similar with more cases:
- Systemic sclerosis (FG)
- Systemic connective tissue disorders
- Autoimmune diseases
- Finngen Rheumatological endpoints
- Used for control exclusion in common control thyroid runs
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4561 | 3620 | 887 |
| Only index persons | 3885 | 3150 | 735 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.02 |
| Only index persons | 0.10 | 0.12 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 56.25 | 56.54 | 55.13 |
| Only index persons | 55.13 | 55.34 | 54.21 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 904 | 745 | 159 |
| Unadjusted period prevalence (%) | 0.23 | 0.26 | 0.07 |
| Median age at first event (years) | 55.58 | 55.23 | 57.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 937
- Matched controls
- 9370
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I73.0
ICD-10 Finland
Raynaud syndrome
59.2
307.7
268
63
XX9XE
NOMESCO Finland
Other ultrasound examination
116.2
307.7
194
21
M34.1
ICD-10 Finland
CR(E)ST syndrome
+∞
307.7
589
*
C08CA05
ATC
nifedipine; systemic
29.1
307.7
405
239
P01BA02
ATC
hydroxychloroquine; oral
26.8
307.7
521
419
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
6771.9
307.7
411
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
29.1
307.7
611
567
L04AX03
ATC
methotrexate; systemic
13.8
307.7
419
518
L04AA06
ATC
mycophenolic acid; systemic
59.7
307.7
187
39
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
99.1
232.6
121
14
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
11.5
223.1
272
323
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
2419.7
197.0
184
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
12.4
195.6
216
221
M34.0
ICD-10 Finland
Progressive systemic sclerosis
+∞
190.3
176
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
8.1
182.0
306
529
G04BE03
ATC
sildenafil; oral
50.2
169.8
99
22
L04AX01
ATC
azathioprine; systemic
13.7
164.6
165
144
L88
ICPC
Rheumatoid/seropositive arthritis
11.0
149.0
174
190
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
45.8
121.2
72
17
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
+∞
120.5
113
*
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
9.8
119.5
150
179
XPX04
NOMESCO Finland
Angioscopy
266.9
116.7
117
5
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.3
106.1
505
2015
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
7.6
103.9
164
256
XG410
NOMESCO Finland
Flow-volume spirometry
9.3
98.4
127
156
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
11.8
94.8
101
95
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.2
90.7
662
3430
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.9
88.6
391
1444
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
907.8
86.0
83
*
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
10.2
85.1
100
108
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
5.8
81.9
171
350
R4120
NOMESCO Finland
Occupational therapy
5.7
78.1
164
337
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
13.8
77.6
74
58
C08CA02
ATC
felodipine; oral
5.0
74.5
187
448
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
72.9
69
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
17.4
70.8
59
36
QC6S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in hand
356.7
67.4
67
*
GD1AD
NOMESCO Finland
Thorax CT examination
5.4
63.3
138
291
NH3EA
NOMESCO Finland
Feet X-ray examination with load
9.6
63.1
77
87
H02AB06
ATC
prednisolone; systemic
3.1
61.5
605
3435
K74.3
ICD-10 Finland
Primary biliary cirrhosis
25.0
60.5
43
18
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.1
59.9
191
546
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
4.0
58.9
196
577
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.4
58.6
272
1000
L01BA01
ATC
methotrexate; systemic
6.9
57.4
94
150
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
10.2
56.3
65
68
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.8
53.9
496
2653
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
8.4
53.4
72
92
M34
ICD-10 Finland
Systemic sclerosis
+∞
52.6
50
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
4.3
52.4
154
412
L04AD01
ATC
ciclosporin; systemic
11.2
51.9
56
53
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
8.1
49.8
69
91
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.8
46.2
162
490
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
17.2
45.5
38
23
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
161.0
44.2
46
*
SBA10
NOMESCO Finland
Measurement of salivary flow rate
12.9
42.0
41
33
J99.1*M34.8
ICD-10 Finland
Respiratory disorders in systemic: sclerosis
+∞
42.0
40
*
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
7.7
42.0
60
82
L04AA01
ATC
[U] ciclosporin
11.8
41.6
43
38
TGC00
NOMESCO Finland
Bronchial lavation
7.1
39.9
62
93
C02KX01
ATC
bosentan; oral
+∞
37.8
36
*
WZA10
NOMESCO Finland
Extensive medical or dental certificate
9.6
37.7
45
49
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
4.5
37.4
98
238
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.4
36.3
149
496
A05AA02
ATC
ursodeoxycholic acid; oral
8.3
35.2
47
59
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
42.8
33.3
41
10
C08CA01
ATC
amlodipine; oral
2.3
32.6
447
2687
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
31.1
295
1511
E0000UV, ,
ATC
2.2
30.2
485
3080
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
6.1
29.9
53
91
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
6.7
29.7
48
75
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.6
29.1
104
315
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.7
28.5
98
289
L99
ICPC
Musculoskeletal disease other
5.9
28.5
52
92
C02KX04
ATC
macitentan; oral
+∞
28.3
27
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.1
27.8
520
3463
J01FF01
ATC
clindamycin; systemic
2.2
27.6
322
1786
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
26.7
276
1453
7101A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic sclerosis[SCLERODERMA]
+∞
26.2
25
*
R06.0
ICD-10 Finland
Dyspnoea
2.2
25.9
329
1877
H02AB07
ATC
prednisone; oral
2.6
25.9
176
766
G73.7*M34.8
ICD-10 Finland
Myopathy in scleroderma
267.7
25.8
26
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
25.7
259
1346
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.8
25.5
59
129
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
3.5
25.2
91
277
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
3.0
25.1
122
445
H04.10
ICD-10 Finland
Dry eye syndrome
2.5
24.8
181
814
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.2
23.6
102
347
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.9
23.6
122
460
XJC02
NOMESCO Finland
Mesurement of oesophageal pressure and pressure profile of lower oesophageal sphincter
55.5
23.2
27
5
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
4.0
22.4
65
170
RT172, ,
NOMESCO Finland
64.1
21.9
25
*
M35.8
ICD-10 Finland
Other specified systemic involvement of connective tissue
225.0
21.7
22
*
K22.4
ICD-10 Finland
Dyskinesia of oesophagus
18.0
21.4
33
19
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
7.7
21.3
30
40
RT160, ,
NOMESCO Finland
61.5
21.0
24
*
A02BC02
ATC
pantoprazole; systemic
2.1
20.9
709
5588
K62.3
ICD-10 Finland
Rectal prolapse
6.5
20.7
34
54
K22.7
ICD-10 Finland
Barrett oesophagus
7.3
20.4
30
42
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.8
20.4
111
429
M01CC01
ATC
penicillamine; oral
58.9
20.0
23
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
19.6
152
699
K22.1
ICD-10 Finland
Ulcer of oesophagus
7.1
19.2
29
42
NHQ40
NOMESCO Finland
Amputation of toe
7.7
19.2
27
36
A02BC01
ATC
omeprazole; systemic
2.0
19.2
293
1755
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
+∞
18.8
18
*
RT274, ,
NOMESCO Finland
39.3
18.6
23
6
UJF32
NOMESCO Finland
Coloscopy
2.0
18.5
288
1733
R4190
NOMESCO Finland
Nutritional therapy
3.7
18.3
59
166
I27.0
ICD-10 Finland
Primary pulmonary hypertension
45.0
18.3
22
5
UJF30
NOMESCO Finland
Ileoscopy through colon
2.4
18.1
137
622
C03CA01
ATC
furosemide; systemic
1.9
17.9
286
1731
M05BA07
ATC
risedronic acid; oral
3.8
17.4
54
148
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
4.9
17.2
38
80
R15
ICD-10 Finland
Faecal incontinence
3.6
17.1
58
169
ZX120
NOMESCO Finland
Intravenous
2.5
17.0
116
501
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.7
16.9
96
379
M05BA04
ATC
alendronic acid; oral
2.5
16.8
115
497
L95
ICPC
Osteoporosis
3.1
16.8
74
254
XQ860
NOMESCO Finland
Laser Doppler measurement/scan of capillary perfusion
+∞
16.7
16
*
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
16.7
16
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.6
16.5
105
439
R50.9
ICD-10 Finland
Fever, unspecified
2.2
16.4
163
828
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
5.3
16.4
33
64
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
16.1
418
2921
J01MA12
ATC
levofloxacin; systemic
2.1
15.9
189
1028
L03.0
ICD-10 Finland
Cellulitis of finger and toe
2.5
15.8
110
480
K11.2
ICD-10 Finland
Sialoadenitis
3.6
15.5
51
146
R4180
NOMESCO Finland
Podiatric therapy
6.6
15.4
25
39
RT271, ,
NOMESCO Finland
38.8
15.4
19
5
S97
ICPC
Chronic ulcer skin
2.8
15.4
78
290
M05BX04
ATC
denosumab; parenteral
2.6
15.0
92
377
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.7
14.9
83
324
I27.8
ICD-10 Finland
Other specified pulmonary heart diseases
32.3
14.8
19
6
N02AX02
ATC
tramadol; systemic, rectal
1.7
14.8
421
3000
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.2
14.7
134
656
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.4
14.6
54
167
E000001, ,
ATC
1.9
14.5
210
1219
M13.9
ICD-10 Finland
Arthritis, unspecified
2.6
14.3
87
355
R4110
NOMESCO Finland
Physiotherapy
1.8
14.3
293
1896
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.3
14.2
114
529
D64.9
ICD-10 Finland
Anaemia, unspecified
2.3
14.2
110
503
PD4AC
NOMESCO Finland
Arterigography of lower extremity with X-ray
6.5
14.1
23
36
A02BC05
ATC
esomeprazole; systemic
1.7
14.0
427
3087
J01DB01
ATC
cefalexin; oral
2.0
13.9
795
6863
Z3226
NOMESCO Finland
Physiotherapist
1.9
13.7
195
1124
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.3
13.7
111
517
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
+∞
13.6
13
*
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
13.6
13
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.1
13.4
58
197
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
4.2
13.4
36
89
M35.7
ICD-10 Finland
Hypermobility syndrome
21.5
13.4
19
9
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
6.4
13.3
22
35
J96.1
ICD-10 Finland
Chronic respiratory failure
5.0
13.2
28
57
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.7
13.0
71
274
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
28.8
13.0
17
6
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.2
13.0
119
583
RT272, ,
NOMESCO Finland
19.4
12.9
19
10
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
22.9
12.9
18
8
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.9
12.9
60
213
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
3.4
12.6
46
141
C02DE02, ,
ATC
11.2
12.6
23
21
R13
ICD-10 Finland
Dysphagia
2.4
12.5
91
404
NDQ20
NOMESCO Finland
Amputation of finger
24.7
12.5
17
7
J02AC01
ATC
fluconazole; systemic
1.6
12.5
441
3282
M33.2
ICD-10 Finland
Polymyositis
131.7
12.5
13
*
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
4.9
12.4
27
56
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.2
12.4
115
566
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
12.3
292
1958
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
12.0
134
707
N03AX16
ATC
[U] pregabalin
1.8
12.0
240
1530
S09
ICPC
Infected finger/toe
3.3
11.9
46
146
D06BX01
ATC
metronidazole; topical
2.0
11.9
136
724
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
4.0
11.9
34
88
RT231, ,
NOMESCO Finland
47.3
11.9
14
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.8
11.8
61
229
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.5
11.6
40
118
73409
ICD-8 Finland
Diffuse diseases of connective tissue, Sclerosis systematica NUD
+∞
11.5
11
*
WZC00
NOMESCO Finland
Treatment plan or consultation
1.6
11.4
364
2624
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.9
11.3
149
833
RT310, ,
NOMESCO Finland
35.5
11.3
14
*
A03FA02
ATC
cisapride; oral, rectal
2.4
11.3
82
364
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.7
11.3
297
2038
S01XA18
ATC
ciclosporin; ophthalmic
8.2
11.1
24
30
S18
ICPC
Laceration/cut
1.6
11.1
454
3470
SPAT1263
SPAT
Sampling
1.6
11.0
392
2894
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.8
11.0
195
1199
K11.71
ICD-10 Finland
Xerostomy (dry mouth)
5.2
10.8
22
43
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
3.3
10.8
41
129
GX1K5
NOMESCO Finland
Diffusion capacity
9.7
10.8
21
22
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.0
10.7
49
172
TEA00
NOMESCO Finland
Biopsy of lip
8.6
10.6
22
26
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
4.4
10.6
26
60
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.7
10.6
220
1414
GX1D5
NOMESCO Finland
Flow volume spirometry
14.4
10.5
17
12
XG466
NOMESCO Finland
Sleep oxymetry
3.5
10.5
36
106
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
10.5
187
1149
B80
ICPC
Iron deficiency anaemia
3.7
10.4
33
92
I73.1
ICD-10 Finland
Thromboangiitis obliterans [Buerger]
+∞
10.4
10
*
J99.1
ICD-10 Finland
Respiratory disorders in other diffuse connective tissue disorders
+∞
10.4
10
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.0
10.4
125
677
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.8
10.3
52
193
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
3.0
10.3
44
149
B02.9
ICD-10 Finland
Zoster without complication
2.3
10.2
81
373
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.9
10.1
129
713
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
3.0
10.1
45
156
R1250
NOMESCO Finland
Evaluation of functional capability
3.3
10.1
37
114
JGC01
NOMESCO Finland
Laparoscopic rectopexy
5.1
10.1
21
42
GD2SN
NOMESCO Finland
Lung ventilation SPECT
9.3
10.0
20
22
R02
ICPC
Shortness of breath/dyspnoea
1.9
10.0
141
805
PB1BC
NOMESCO Finland
Extensive angiography of upper extremity with X-ray
40.5
10.0
12
*
J01MA02
ATC
ciprofloxacin; systemic
1.6
9.9
341
2483
K23.8*B37.8
ICD-10 Finland
Esophagitis caused by candidiasis
16.9
9.9
15
9
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.4
9.9
66
282
TPH04, ,
SPAT
5.0
9.8
21
43
D07AC01
ATC
betamethasone; topical
1.6
9.7
348
2556
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.8
9.7
163
983
M35
ICD-10 Finland
Other systemic involvement of connective tissue
55.6
9.7
11
*
JC2AB
NOMESCO Finland
Oesophagus X-ray examination with contrast
5.1
9.6
20
40
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
8.5
9.6
20
24
SAA03
NOMESCO Finland
Extended examination of mouth
1.6
9.5
374
2804
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.5
9.5
58
238
G73.7
ICD-10 Finland
Myopathy in other diseases classified elsewhere
101.0
9.4
10
*
I78.8
ICD-10 Finland
Other diseases of capillaries
101.0
9.4
10
*
R76.0
ICD-10 Finland
Raised antibody titre
17.7
9.4
14
8
A02BC03
ATC
lansoprazole; oral
1.6
9.4
285
2009
383
Kela drug reimbursment
Selexipag
+∞
9.4
9
*
B01AC27
ATC
selexipag; oral
+∞
9.4
9
*
M31.4
ICD-10 Finland
Aortic arch syndrome [Takayasu]
+∞
9.4
9
*
M34.2
ICD-10 Finland
Systemic sclerosis induced by drugs and chemicals
+∞
9.4
9
*
R22.3
ICD-10 Finland
Localized swelling, mass and lump, upper limb
3.5
9.4
32
94
K07.65
ICD-10 Finland
Temporomandibular joint-pain-dysfunction syndrome
5.2
9.4
19
37
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
10.8
9.3
17
16
SPAT1255
SPAT
Intravenous administration of medicine
2.4
9.1
62
267
L84
ICD-10 Finland
Corns and callosities
2.9
9.1
43
154
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.0
9.1
103
545
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.8
9.0
147
877
SPAT1249
SPAT
Treatment-related counselling outside office
1.5
9.0
364
2734
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
3.5
9.0
31
92
Z2221
NOMESCO Finland
Medical doctor
1.6
8.9
266
1863
J01MA14
ATC
moxifloxacin; systemic
2.1
8.9
92
472
WX002
NOMESCO Finland
Sedation and analgesia
1.7
8.8
182
1162
C08DB01
ATC
diltiazem; oral
2.6
8.7
51
205
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
6.7
8.7
21
32
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
50.5
8.7
10
*
XF614
NOMESCO Finland
Measurement of pulmonary artery pressure
50.5
8.7
10
*
TQW80
NOMESCO Finland
Local dermatologic skincare
3.4
8.7
30
89
M25.5
ICD-10 Finland
Pain in joint
1.5
8.6
340
2536
WZC30
NOMESCO Finland
Teaching
1.7
8.6
162
1008
A06AC51
ATC
ispaghula, combinations; oral
2.4
8.6
56
237
XF622
NOMESCO Finland
Measurement of minute volume of heart
27.8
8.5
11
*
G04BE08
ATC
tadalafil; oral
27.8
8.5
11
*
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
4.2
8.5
22
53
NDQ48
NOMESCO Finland
Revision or amputation or exarticulation of finger
20.2
8.5
12
6
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.7
8.5
160
996
L12
ICPC
Hand/finger symptom/complaint
1.7
8.4
186
1207
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.1
8.4
76
370
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
3.4
8.4
30
91
NJ3CG
NOMESCO Finland
Extensive MRI examination of extremities with median high magnet
12.9
8.4
14
11
C02KX02
ATC
ambrisentan; oral
+∞
8.3
8
*
M32
ICD-10 Finland
Systemic lupus erythematosus
+∞
8.3
8
*
M43.9
ICD-10 Finland
Deforming dorsopathy, unspecified
+∞
8.3
8
*
286
Kela drug reimbursment
Ciclosporin eye drop
+∞
8.3
8
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
8.3
140
843
NF1AA
NOMESCO Finland
Hip X-ray examination
2.0
8.3
93
491
B01AC04
ATC
clopidogrel; oral
1.8
8.3
136
813
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.6
8.2
273
1955
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
4.3
8.2
21
50
SPAT1360
SPAT
Extensive global examination
2.2
8.2
67
313
L04AA13
ATC
[U] leflunomide
3.2
8.1
31
98
A10BA02
ATC
metformin; oral
0.5
8.1
104
1758
A03
ICPC
Fever
1.7
8.1
157
984
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.9
8.1
113
643
C03DA01
ATC
spironolactone; oral
1.9
8.1
113
643
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
3.2
8.0
31
99
SFA00
NOMESCO Finland
Small restoration
1.7
8.0
144
884
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
2.9
8.0
36
126
H03AA01
ATC
levothyroxine sodium; systemic
1.6
7.9
256
1820
E000006, ,
ATC
2.1
7.9
77
386
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
4.7
7.9
18
39
J05AB01
ATC
aciclovir; systemic
1.6
7.9
226
1563
M43.0
ICD-10 Finland
Spondylolysis
3.8
7.8
23
61
M05BB03
ATC
alendronic acid and colecalciferol; oral
3.1
7.8
32
106
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
2.7
7.8
42
162
XQ848
NOMESCO Finland
Dermatological photography
3.0
7.8
34
117
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.2
7.8
68
327
J01CA04
ATC
amoxicillin; systemic
1.6
7.7
759
6784
EBA10
NOMESCO Finland
Operative extraction of tooth
1.9
7.7
102
569
L01AA01
ATC
cyclophosphamide; systemic
15.2
7.7
12
8
Z94.2
ICD-10 Finland
Lung transplant status
45.4
7.7
9
*
GDG10
NOMESCO Finland
Bilateral transplantation of lung
45.4
7.7
9
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.1
7.7
74
369
E000003, ,
ATC
2.5
7.7
48
199
D02AX
ATC
Other emollients and protectives
2.9
7.7
36
129
SPAT1254
SPAT
Administration of medicine
1.8
7.6
128
770
R60.0
ICD-10 Finland
Localized oedema
1.8
7.6
126
755
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
3.3
7.6
28
87
M35.3
ICD-10 Finland
Polymyalgia rheumatica
3.4
7.6
26
77
NFQ20
NOMESCO Finland
Amputation of femur
8.9
7.6
15
17
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
10.1
7.5
14
14
Z3229
NOMESCO Finland
Other healthcare associate professional
2.1
7.5
76
386
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.5
7.5
363
2803
I50.9
ICD-10 Finland
Heart failure, unspecified
1.9
7.5
102
575
R81
ICPC
Pneumonia
2.7
7.4
39
149
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
6.9
7.3
17
25
PD4AD
NOMESCO Finland
CT of lower extremity arteries
6.9
7.3
17
25
E000007, ,
ATC
2.2
7.3
58
268
L94.3
ICD-10 Finland
Sclerodactyly
+∞
7.3
7
*
73410
ICD-8 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
+∞
7.3
7
*
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
7.3
7
*
73401
ICD-8 Finland
Diffuse diseases of connective tissue, Sclerosis systematica acrosclerotica
+∞
7.3
7
*
PD4DE
NOMESCO Finland
Lower extremity artery ultrasound examination with Doppler method
4.2
7.3
19
46
JN3AD
NOMESCO Finland
Abdominal CT examination
1.8
7.2
122
734
SPAT1211
SPAT
Application of soft bandage
2.0
7.2
83
442
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
1.7
7.2
125
758
JDA52
NOMESCO Finland
Other endoscopic procedure using diathermy or heat in stomach or pylorus
30.3
7.2
9
*
K74.5
ICD-10 Finland
Biliary cirrhosis, unspecified
30.3
7.2
9
*
J01FA06
ATC
roxithromycin; oral
1.5
7.1
378
2965
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
7.1
170
1122
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
20.2
7.1
10
5
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
8.0
7.1
15
19
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
2.5
7.1
42
170
ZX108
NOMESCO Finland
Inhalation
12.1
7.1
12
10
J01DA01
ATC
[U] cefalexin
1.5
7.1
572
4855
RJ420, ,
NOMESCO Finland
10.1
7.0
13
13
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
2.5
7.0
45
189
M70.2
ICD-10 Finland
Olecranon bursitis
3.0
7.0
30
102
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.8
7.0
103
596
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.8
7.0
111
657
E000002, ,
ATC
1.8
7.0
101
581
D50.8
ICD-10 Finland
Other iron deficiency anaemias
4.0
6.9
19
48
K11.70
ICD-10 Finland
Hypoptyalism
7.6
6.9
15
20
JCA55
NOMESCO Finland
Endoscopic dilatation of oesophagus
6.8
6.8
16
24
RK220, ,
NOMESCO Finland
11.0
6.8
12
11
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
11.0
6.8
12
11
N02BE01
ATC
paracetamol; systemic, rectal
1.8
6.8
843
7806
L17
ICPC
Foot/toe symptom/complaint
1.5
6.8
297
2240
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
5.7
6.8
18
32
K76.9
ICD-10 Finland
Liver disease, unspecified
3.7
6.8
21
58
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
4.3
6.8
17
40
L94.9
ICD-10 Finland
Localized connective tissue disorder, unspecified
40.3
6.8
8
*
TPH07
NOMESCO Finland
Cathetrisation of artery
1.8
6.8
99
571
NXL00
NOMESCO Finland
Biopsy of muscle
16.8
6.8
10
6
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.5
6.7
259
1903
TQW99
NOMESCO Finland
Other minor procedure on skin
2.3
6.7
52
238
Z3231
NOMESCO Finland
Registered nurse
1.5
6.7
238
1720
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.6
6.7
153
999
RT171, ,
NOMESCO Finland
22.7
6.7
9
*
ADA20
NOMESCO Finland
Thoracal sympathectomy
22.7
6.7
9
*
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
6.5
6.7
16
25
NH1AE
NOMESCO Finland
Ankle joint ultrasound examination
6.5
6.7
16
25
J01AA04
ATC
lymecycline; systemic
1.7
6.6
121
744
SPAT1229
SPAT
Assessment of need for aid
2.0
6.6
70
362
SPAT1312
SPAT
General health counselling
1.5
6.6
274
2042
A46
ICD-10 Finland
Erysipelas
1.7
6.6
120
737
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
2.4
6.6
44
189
C01DA14
ATC
isosorbide mononitrate; oral
1.8
6.6
111
668
SHA04
NOMESCO Finland
Stomatognathic treatment, very demanding
4.2
6.6
17
41
A07AA09
ATC
vancomycin; oral
4.2
6.6
17
41
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.6
6.6
150
979
L93.0
ICD-10 Finland
Discoid lupus erythematosus
8.8
6.6
13
15
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
6.6
134
850
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.1
6.5
64
322
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
1.8
6.5
103
608
D02AE01
ATC
carbamide; topical
2.1
6.5
63
316
S20
ICPC
Corn/callosity
3.2
6.5
25
80
UJF92
NOMESCO Finland
Capsular endoscopy
3.3
6.4
23
70
G73.7*M35.0
ICD-10 Finland
Myopathy in sicca syndrome [Sjögren]
70.3
6.4
7
*
M35.4
ICD-10 Finland
Diffuse (eosinophilic) fasciitis
70.3
6.4
7
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
6.4
163
1091
SAA04
NOMESCO Finland
Special examination of mouth
2.2
6.4
51
236
I50.0
ICD-10 Finland
Congestive heart failure
2.1
6.4
57
276
M43.1
ICD-10 Finland
Spondylolisthesis
2.3
6.4
49
223
TNB11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in shoulder joint
7.5
6.4
14
19
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
2.9
6.4
29
102
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.0
6.4
73
388
A07AA02
ATC
nystatin; oral
2.1
6.4
62
311
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.6
6.4
140
905
ZY010
NOMESCO Finland
Hospital outpatient
2.2
6.3
52
244
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
2.7
6.3
32
120
I83.9
ICD-10 Finland
Varicose veins of lower extremities without ulcer or inflammation
1.7
6.3
111
676
J94.8
ICD-10 Finland
Other specified pleural conditions
3.9
6.3
18
47
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
6.3
6
*
XQ844
NOMESCO Finland
Other microscope or electron microscope examination
+∞
6.3
6
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.7
6.3
131
836
GD1CQ
NOMESCO Finland
Lung circulation SPECT with low dose CT
26.9
6.2
8
*
GD1UN
NOMESCO Finland
Lung circulation SPECT
7.1
6.2
14
20
SPAT1070
SPAT
Doppler ultrasound examination of blood flow in arteries of lower extremity
3.6
6.2
20
57
SBB10
NOMESCO Finland
Dental impressions
2.0
6.2
63
322
NDL52
NOMESCO Finland
Tenosynovectomy of hand
5.4
6.2
17
32
N02AA05
ATC
oxycodone; systemic
1.6
6.1
159
1069
K29.7
ICD-10 Finland
Gastritis, unspecified
2.4
6.1
40
170
A01AB09
ATC
miconazole; local oral
1.8
6.1
88
505
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
2.2
6.1
49
228
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
0.6
6.1
104
1639
PF1BT
NOMESCO Finland
Extensive PTA of arteries of knee, lower leg and ankle
12.6
6.1
10
8
N02BF02
ATC
pregabalin; oral
1.9
6.1
73
395
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
2.8
6.1
30
111
XG499
NOMESCO Finland
Other fysiological examination of respiatory function
10.1
6.0
11
11
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
2.7
6.0
31
117
WX203
NOMESCO Finland
Infraclavicular plexus blockade
2.9
6.0
28
100
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.5
6.0
184
1284
PHD76
NOMESCO Finland
Resection of long saphenous vein
2.2
6.0
51
243
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
584
1192
11.35
320.06
2.0
1.3
1893.51
404.92
titre
45.93
388
252
324
319
15.00
307.83
1.7
1.1
6.98
1.82
u/ml
2.37
26
16
436
322
24.45
307.65
2.6
1.3
6.83
5.17
iu/ml
0.55
142
61
310
214
21.15
307.65
2.4
1.2
0.20
0.25
g/l
7.18
298
203
310
227
19.91
307.65
2.4
1.2
1.09
1.23
g/l
7.51
299
213
429
221
34.96
307.65
1.7
1.1
3.31
2.67
u/ml
0.25
104
12
425
221
34.36
307.65
1.8
1.2
8.23
3.19
u/ml
1.61
156
21
351
183
30.07
307.65
1.7
1.1
37.21
32.44
u/ml
0.12
62
14
338
178
29.14
307.65
1.6
1.2
4.70
—
u/ml
—
12
0
433
239
32.82
307.65
1.7
1.1
7.77
6.17
u/ml
—
29
7
408
168
42.25
307.65
1.6
1.1
30.82
16.24
u/ml
—
58
5
183
66
34.21
278.00
1.3
1.2
—
—
—
0
0
120
27
50.83
205.85
1.3
1.2
—
—
—
0
0
708
2541
8.31
202.18
5.5
3.0
717.49
1016.05
ng/l
1.98
664
2147
137
55
29.00
199.20
1.4
1.1
—
—
—
0
0
137
55
29.00
199.20
1.4
1.1
—
—
—
0
0
136
54
29.29
198.50
1.4
1.1
—
—
—
0
0
135
53
29.59
197.81
1.4
1.1
—
—
—
0
0
137
58
27.49
195.32
1.4
1.1
—
—
—
0
0
97
23
46.93
163.83
2.8
1.2
8.69
8.60
ug/l
0.04
97
23
123
77
18.24
147.31
1.4
1.1
20.82
—
u/ml
—
17
0
843
4496
9.72
131.71
15.9
5.8
1.69
1.92
e9/l
8.97
819
3927
847
4561
9.92
130.21
16.3
6.1
0.19
0.19
e9/l
0.20
823
3951
280
629
5.92
124.33
3.8
2.9
10.28
10.40
g/l
0.15
266
578
82
38
23.55
111.85
1.2
1.1
—
—
—
0
0
594
2620
4.46
109.30
3.5
2.1
102.63
193.79
u/l
3.21
578
2484
847
4958
8.37
106.74
18.8
9.4
3.84
3.96
e9/l
1.11
817
4304
92
67
15.12
101.06
1.5
1.1
40.57
—
u/ml
—
7
0
244
594
5.20
96.97
4.7
3.0
114.00
175.90
ng/l
2.51
235
540
215
505
5.23
88.56
1.8
1.8
1.43
1.31
g/l
0.46
200
462
776
4582
5.04
86.35
6.8
3.9
6.85
5.14
estimate
0.09
200
956
768
4535
4.84
84.52
6.8
3.9
0.00
0.00
estimate
0.50
198
928
772
4631
4.79
81.70
6.8
3.9
0.00
0.35
estimate
0.53
200
904
472
2128
3.45
76.09
3.8
2.6
317.13
326.95
umol/l
1.26
439
1879
45
11
42.92
74.63
1.0
1.1
—
—
—
0
0
49
18
28.67
72.35
1.0
1.2
—
—
—
0
0
884
6404
7.72
61.41
13.2
4.1
12.84
12.14
mm/h
0.96
876
5996
390
1763
3.08
59.23
1.4
1.3
38.27
30.30
iu/ml
0.45
165
543
156
390
4.60
58.26
2.4
2.1
0.00
0.01
estimate
0.50
52
121
43
20
22.49
58.05
1.3
1.1
—
—
—
0
0
666
4166
3.07
53.68
3.7
2.5
80.68
78.91
nmol/l
0.92
630
3762
879
6646
6.21
50.17
16.7
7.8
77.31
78.86
u/l
0.40
874
6308
115
252
5.06
50.15
1.6
1.5
0.07
0.09
iu/ml
0.08
14
40
462
2505
2.67
47.00
7.2
4.0
0.00
0.00
estimate
0.99
197
890
600
3838
2.57
41.19
21.6
10.8
0.00
0.00
e9/l
0.19
547
3129
656
4379
2.66
41.14
9.6
6.7
1.21
1.22
mmol/l
0.96
577
3789
92
197
5.07
41.03
2.0
2.0
122.66
128.97
g/l
0.87
32
157
359
1831
2.56
39.94
1.7
1.5
2.23
2.36
g/l
0.67
248
1103
71
123
6.16
39.80
1.5
1.2
3.43
4.14
u/ml
0.12
35
37
70
121
6.17
39.32
1.5
1.2
7.25
6.00
u/ml
0.14
36
47
603
3923
2.51
39.00
8.6
5.9
1.22
1.22
mmol/l
0.38
577
3625
102
260
4.28
36.60
3.0
2.1
110.90
234.87
ug/l
3.25
95
246
321
1634
2.47
35.01
1.3
1.3
12.66
11.04
u/ml
0.15
127
613
97
247
4.27
34.81
2.4
2.7
—
—
—
0
0
49
66
7.78
34.64
1.9
1.4
—
—
—
0
0
281
1388
2.46
32.33
3.7
2.4
11.13
13.13
umol/l
4.83
272
1296
174
678
2.92
32.19
2.1
3.0
65.05
66.94
g/l
2.27
162
624
574
3849
2.27
31.75
6.8
4.6
35.72
36.01
g/l
0.68
550
3616
527
3447
2.21
30.54
6.8
3.8
0.03
0.08
estimate
0.55
180
768
381
2217
2.21
29.32
3.8
2.2
2.90
2.86
mg/l
0.11
348
1898
245
1184
2.45
29.19
3.6
2.4
19.90
22.38
%
1.67
233
1112
259
1293
2.39
28.63
3.6
2.3
2.35
2.35
g/l
0.01
249
1194
70
163
4.56
28.08
1.9
1.3
—
—
—
0
0
326
1840
2.18
26.53
4.0
2.5
3.77
7.09
e6/l
5.92
313
1685
36
47
7.93
26.07
1.9
2.4
—
—
—
0
0
383
2314
2.11
26.01
4.6
3.0
0.20
0.43
e6/l
2.93
315
1681
260
1348
2.29
25.99
2.5
1.8
—
—
—
0
0
424
2675
2.07
25.49
4.8
3.0
18.40
73.60
e6/l
1.43
363
2030
267
1431
2.21
24.41
3.5
2.7
0.73
1.16
e6/l
2.66
181
722
76
216
3.74
23.30
2.0
1.4
—
—
—
0
0
180
830
2.45
23.28
2.8
2.1
0.20
0.21
g/l
1.73
168
779
394
2481
2.01
23.24
5.6
3.2
0.00
0.04
estimate
0.69
178
751
96
321
3.22
22.88
2.0
2.2
2.93
2.91
g/l
0.06
91
293
70
191
3.88
22.74
1.9
1.4
—
—
—
0
0
62
159
4.10
21.93
1.9
1.4
—
—
—
0
0
31
42
7.60
21.73
1.3
1.1
—
—
—
0
0
98
342
3.08
21.72
1.9
2.2
3.23
3.73
g/l
3.25
93
315
76
227
3.56
21.64
2.0
1.5
—
—
—
0
0
98
343
3.07
21.60
1.9
2.2
7.14
7.40
g/l
0.94
93
315
98
343
3.07
21.60
1.9
2.2
4.06
4.32
g/l
2.31
93
315
201
1014
2.25
20.96
2.3
1.7
—
—
—
0
0
59
151
4.10
20.92
12.8
4.6
1511.74
153.82
iu/ml
0.88
19
17
613
4613
1.95
20.33
8.6
6.4
10.03
10.76
umol/l
1.13
591
4403
173
837
2.31
19.85
1.8
2.1
344.24
389.34
nmol/l
1.53
160
776
140
617
2.49
19.79
2.0
1.6
—
—
—
0
0
342
2149
1.93
19.48
1.4
1.3
0.55
1.41
u/ml
2.72
82
582
50
121
4.31
19.08
1.3
1.5
150.00
159.69
au/ml
—
9
34
85
296
3.06
18.87
2.0
2.3
1.00
1.08
g/l
0.05
78
254
86
302
3.03
18.81
2.0
2.2
10.30
10.31
g/l
0.01
80
273
203
1072
2.14
18.69
5.8
4.9
1.05
1.04
mmol/l
0.12
185
984
51
128
4.16
18.56
1.2
1.1
193.33
106.67
titre
—
6
9
54
143
3.95
18.28
2.0
1.6
—
—
—
0
0
149
701
2.34
18.14
2.6
2.7
71.91
72.61
e9/l
0.08
115
515
519
3787
1.83
17.97
15.0
13.0
1.19
1.20
inr
0.15
442
3112
57
164
3.64
17.14
1.7
1.4
—
—
—
0
0
53
146
3.79
16.98
1.4
1.3
—
—
—
0
0
183
967
2.11
16.66
2.4
1.8
—
—
—
0
0
48
126
3.96
16.45
1.6
1.4
—
—
—
0
0
27
43
6.44
16.35
1.4
2.3
353.47
484.31
e6/l
0.75
19
36
312
1993
1.85
16.29
7.2
4.1
1.02
1.78
kg/l
0.50
249
1313
73
259
2.97
15.66
2.1
2.0
0.00
0.00
g/l
-0.00
67
223
66
221
3.14
15.64
1.1
1.2
—
—
—
0
0
27
46
6.01
15.32
1.6
2.4
199.10
229.29
e6/l
0.23
21
41
34
72
4.86
15.28
1.4
1.2
—
—
—
0
0
37
87
4.39
14.65
1.8
1.6
52.41
58.22
%
0.34
22
55
86
350
2.60
14.23
2.0
1.8
1.51
1.54
g/l
0.12
78
308
543
4177
1.71
14.21
4.4
3.0
104.61
104.69
ug/l
0.00
513
3908
438
3182
1.71
14.14
3.3
3.6
2.35
2.36
mmol/l
1.24
406
2908
30
62
4.97
13.87
1.4
1.1
117.50
80.00
titre
—
8
8
28
55
5.22
13.70
1.8
1.7
44.18
36.33
%
0.34
13
32
167
917
2.00
13.49
10.8
7.9
4.85
5.10
kpa
2.85
161
889
133
673
2.14
13.39
2.7
2.2
0.23
0.56
e6/l
1.11
124
635
439
3224
1.68
13.37
5.1
3.6
26.22
43.50
ng/l
0.81
309
2181
61
215
2.97
13.25
1.7
1.4
—
—
—
0
0
31
70
4.55
12.92
1.7
1.3
2281.89
1830.56
e6/l
0.20
18
43
38
103
3.80
12.48
2.5
1.5
—
—
—
0
0
898
8232
3.18
12.45
32.5
14.7
18.31
22.61
mg/l
4.58
811
6726
253
1625
1.76
12.41
5.2
3.8
218.74
309.04
ng/l
0.50
202
1207
228
1421
1.80
12.39
5.3
3.1
0.82
0.82
mmol/l
0.01
211
1350
200
1199
1.85
12.33
2.0
2.2
174.24
120.68
ug/g
1.05
163
952
162
908
1.95
12.27
11.1
7.9
0.86
1.06
mmol/l
0.29
138
756
127
655
2.09
12.12
9.3
6.6
9.10
9.06
mmol/l
0.02
120
633
675
5624
1.72
12.09
6.9
4.7
168.56
1541.28
e6/l
—
9
71
69
273
2.65
12.08
2.4
3.8
59.33
66.25
mg/l
0.10
62
232
402
2943
1.64
11.99
5.2
3.1
31.00
31.12
u/l
0.03
388
2772
70
280
2.62
11.99
1.5
1.4
314.91
296.47
ug/g
0.30
38
158
68
273
2.61
11.57
2.5
3.8
30.72
55.07
mg/l
0.98
60
232
11
0
+∞
11.48
1.0
0.0
—
—
—
0
0
352
2532
1.62
11.03
1.9
1.7
21.11
21.26
nmol/l
0.07
314
2123
30
75
4.10
11.01
1.3
1.4
—
—
—
0
0
30
75
4.10
11.01
1.3
1.4
—
—
—
0
0
30
75
4.10
11.01
1.3
1.4
—
—
—
0
0
109
553
2.10
10.84
1.3
1.3
37.17
41.45
au/ml
—
9
44
27
63
4.38
10.82
1.7
1.3
6241.75
159140.77
e6/l
0.69
12
30
128
690
1.99
10.79
4.0
3.7
1.23
1.23
mmol/l
0.80
119
596
61
244
2.60
10.46
2.2
3.7
6.36
4.31
ratio
0.24
34
135
30
78
3.94
10.45
1.8
1.6
—
—
—
0
0
376
2777
1.59
10.41
3.1
2.4
59.13
63.10
u/l
0.60
345
2563
115
609
2.01
10.17
2.6
2.5
28.03
26.39
au/ml
0.07
17
59
39
124
3.24
10.11
1.2
1.1
—
—
—
0
0
21
42
5.09
10.08
1.2
1.5
—
—
—
0
0
21
42
5.09
10.08
1.2
1.5
—
—
—
0
0
21
42
5.09
10.08
1.2
1.5
—
—
—
0
0
21
42
5.09
10.08
1.2
1.5
—
—
—
0
0
62
257
2.51
9.89
1.3
1.2
—
—
—
0
0
284
1984
1.62
9.79
2.1
1.7
1.34
1.09
mg/l
0.41
233
1548
23
52
4.51
9.59
2.8
2.9
45.56
39.19
%
0.65
16
26
70
313
2.34
9.48
2.1
1.9
1.35
2.05
ug/l
0.33
61
285
210
1370
1.69
9.43
1.8
1.7
1185.54
1200.72
nmol/l
0.09
168
1018
20
25
8.15
9.37
1.7
1.3
—
—
—
0
0
37
120
3.17
9.30
3.2
3.3
2.08
1.37
%
0.27
37
111
615
5157
1.56
9.24
3.1
3.0
—
—
—
0
0
30
86
3.57
9.13
1.8
1.5
—
—
—
0
0
51
200
2.64
9.12
1.7
1.6
4755.50
11526.96
e6/l
1.16
38
141
40
138
2.98
9.06
1.3
1.3
307.50
253.17
u/ml
0.54
24
78
34
107
3.26
8.98
2.2
1.4
—
—
—
0
0
481
3848
1.51
8.80
2.3
2.1
98.53
97.66
pmol/l
0.13
253
1925
35
114
3.15
8.75
1.4
1.4
—
—
—
0
0
593
4962
1.53
8.74
7.5
4.7
6.38
6.60
mmol/l
1.73
577
4709
85
433
2.06
8.35
5.6
3.2
2.00
1.95
mmol/l
0.04
61
330
113
638
1.88
8.26
1.3
1.3
71.39
216.92
u/ml
2.48
106
590
27
79
3.49
7.99
3.1
2.9
58.94
58.15
%
0.06
27
73
294
2159
1.53
7.85
6.5
3.8
92.40
92.63
%
0.06
285
2110
14
13
10.91
7.81
1.0
1.1
100.64
104.54
%
0.18
14
13
156
987
1.70
7.74
2.8
2.6
5.65
7.06
umol/l
0.75
142
866
193
1299
1.61
7.51
4.2
2.8
2.88
3.33
e6/l
0.20
102
587
24
69
3.54
7.30
1.6
1.5
242597.19
131913.82
e6/l
0.17
16
45
51
223
2.36
7.30
1.7
1.6
—
—
—
0
0
45
187
2.48
7.19
1.2
1.5
—
—
—
0
0
28
90
3.18
7.18
1.2
1.2
—
—
—
0
0
43
183
2.41
6.55
1.6
1.5
—
—
—
0
0
12
12
10.11
6.54
2.8
8.0
6.88
4.88
kpa
0.47
12
12
17
30
5.75
6.47
1.1
1.5
—
—
—
0
0
17
30
5.75
6.47
1.1
1.5
—
—
—
0
0
17
30
5.75
6.47
1.1
1.6
—
—
—
0
0
57
276
2.13
6.43
1.2
1.3
—
—
—
0
0
59
290
2.10
6.40
2.5
1.9
—
—
—
0
0
29
104
2.85
6.20
1.1
1.1
—
—
—
0
0
241
1782
1.47
5.98
1.7
1.7
28985970.81
35330189.84
pmol/l
0.07
207
1486
116
726
1.68
5.96
3.6
3.4
72.92
80.75
ng/l
0.74
101
627
84
483
1.81
5.80
1.9
1.7
—
—
—
0
0
54
267
2.09
5.79
2.1
1.8
—
—
—
0
0
110
689
1.68
5.63
3.0
2.5
67.48
67.16
ml/min/173m2
0.03
52
292
12
18
6.74
5.26
1.3
1.2
—
—
—
0
0
17
49
3.52
5.19
1.2
1.2
22.00
26.60
u/l
0.25
17
43
17
49
3.52
5.19
1.2
1.2
85.18
78.09
u/l
0.18
17
44
242
1845
1.42
4.99
2.7
2.8
2.46
2.46
mmol/l
0.37
220
1684
757
6951
1.46
4.97
5.3
4.7
15.24
14.74
pmol/l
7.27
706
6427
16
37
4.38
4.95
1.6
3.8
826.31
1279.84
u/ml
0.47
16
37
12
20
6.06
4.92
1.6
1.2
—
—
—
0
0
20
67
3.03
4.85
2.1
1.5
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
45
224
2.06
4.78
3.2
3.1
0.37
0.38
iu/ml
0.04
24
125
16
47
3.45
4.76
1.1
1.1
—
—
—
0
0
24
92
2.65
4.59
4.4
3.4
—
—
—
0
0
16
49
3.30
4.48
2.3
1.3
—
—
—
0
0
101
657
1.60
4.47
2.6
2.3
15.81
6.39
ug/l
0.58
85
580
12
23
5.27
4.46
1.2
1.0
—
—
—
0
0
57
319
1.84
4.34
1.8
1.6
—
—
—
0
0
118
805
1.53
4.25
4.1
3.2
1.51
1.91
mmol/l
0.57
104
692
77
474
1.68
4.24
4.4
3.1
23.81
24.34
mmol/l
0.81
77
468
852
8080
1.60
4.16
26.4
14.6
80.51
80.68
ml/min/173m2
0.08
821
7499
16
53
3.05
3.98
2.4
1.3
—
—
—
0
0
8
11
7.32
3.86
2.4
8.5
11.55
9.45
%
—
8
11
43
229
1.92
3.84
3.1
3.2
1.33
2.25
index
0.70
15
114
16
55
2.94
3.75
2.3
1.3
—
—
—
0
0
261
2112
1.33
3.57
3.4
2.3
—
—
—
0
0
7
9
7.83
3.56
3.0
1.3
—
—
—
0
0
25
113
2.25
3.44
1.1
1.1
—
0.29
—
0
6
458
4018
1.27
3.33
3.7
2.7
—
—
estimate
—
0
0
99
690
1.49
3.25
1.8
1.5
—
—
—
0
0
835
7966
1.44
3.07
6.7
5.8
2.04
1.89
mu/l
2.48
787
7412
23
106
2.20
3.05
1.3
1.3
—
—
—
0
0
41
687
0.58
3.02
1.6
1.8
3.35
3.48
mmol/l
0.34
28
499
23
107
2.18
2.98
1.3
1.3
—
—
—
0
0
18
75
2.43
2.98
1.7
1.1
90.61
110.99
pmol/l
1.07
18
75
116
849
1.42
2.96
2.4
2.3
32.33
38.86
u/l
1.20
103
703
30
156
1.95
2.92
4.6
2.8
34.96
33.59
umol/l
0.10
25
140
18
77
2.36
2.83
2.2
2.1
—
—
—
0
0
61
913
0.65
2.81
1.6
2.0
3.22
3.34
ratio
0.30
46
721
34
189
1.83
2.74
1.2
1.5
2.50
14.99
e6/l
1.59
26
139
34
191
1.81
2.65
1.3
1.5
394.52
548.09
e6/l
0.14
27
147
12
43
2.81
2.65
1.2
1.3
—
—
—
0
0
12
43
2.81
2.65
1.2
1.3
—
—
—
0
0
22
106
2.10
2.64
1.3
1.3
—
—
—
0
0
23
113
2.06
2.63
1.3
1.2
—
—
—
0
0
23
113
2.06
2.63
1.3
1.2
—
—
—
0
0
6
11
5.48
2.54
1.0
1.3
—
—
—
0
0
7
16
4.40
2.47
1.3
1.3
—
—
—
0
0
8
21
3.83
2.46
3.1
2.5
3.88
6.23
ug/l
—
8
21
111
842
1.36
2.32
4.8
3.2
—
—
—
0
0
22
112
1.99
2.32
1.3
1.2
—
—
—
0
0
17
79
2.17
2.25
2.9
3.0
12.67
12.49
index
—
9
45
5
9
5.58
2.21
1.0
1.0
—
—
—
0
0
11
41
2.70
2.21
1.4
1.1
0.56
0.51
ratio
—
5
23
27
151
1.81
2.18
1.4
1.3
—
—
—
0
0
27
151
1.81
2.18
1.4
1.3
—
—
—
0
0
9
30
3.02
2.15
3.3
5.2
—
—
—
0
0
9
30
3.02
2.15
1.2
1.1
—
—
—
0
0
20
104
1.94
2.01
11.8
6.4
13.83
12.27
mg/l
0.74
20
98
24
135
1.80
1.92
1.3
1.2
0.75
13.70
nmol/l
0.49
24
130
870
8466
1.39
1.83
28.5
17.4
139.38
139.71
mmol/l
3.11
862
8313
50
347
1.47
1.77
2.0
3.1
23.34
1058.55
u/ml
1.62
44
306
19
104
1.84
1.68
3.1
2.3
32.47
31.89
pg
0.23
19
104
8
31
2.59
1.66
1.0
1.0
—
—
—
0
0
7
25
2.81
1.65
1.4
2.0
36.41
41.80
g/l
—
7
25
5
14
3.58
1.61
1.0
1.1
—
—
—
0
0
39
264
1.50
1.58
1.4
1.3
234.10
228.02
miu/ml
0.04
17
130
7
26
2.70
1.58
2.7
2.5
0.60
0.63
mmol/l
—
7
26
16
282
0.56
1.52
1.3
1.6
990.23
993.15
mu/l
—
10
222
208
1801
1.20
1.50
1.4
1.4
—
—
—
0
0
868
8477
1.33
1.46
28.7
17.6
3.94
3.95
mmol/l
0.56
859
8303
19
310
0.60
1.37
1.1
1.2
1.57
1.60
g/l
0.23
19
310
8
163
0.49
1.36
1.1
1.4
—
—
—
0
0
10
193
0.51
1.30
1.5
1.5
—
—
—
0
0
11
55
2.01
1.27
1.2
1.5
13.49
9.95
umol/l
0.88
11
49
8
35
2.30
1.27
1.1
2.3
—
—
—
0
0
8
36
2.23
1.24
1.4
1.1
—
86.20
—
0
5
9
45
2.01
1.23
2.0
3.2
0.67
0.84
index
—
9
45
35
248
1.43
1.18
1.5
1.3
—
—
—
0
0
6
130
0.46
1.16
2.2
1.7
—
—
—
0
0
5
20
2.51
1.15
1.0
1.1
—
—
—
0
0
21
319
0.65
1.15
1.1
1.2
0.92
0.90
g/l
0.15
21
319
116
977
1.21
1.14
8.9
6.7
—
—
—
0
0
0
36
0.00
1.14
0.0
2.0
—
31.20
—
0
5
0
36
0.00
1.14
0.0
1.2
—
—
—
0
0
600
5715
1.14
1.13
4.6
3.3
55.44
45.60
u/l
2.15
566
5385
11
58
1.91
1.12
1.0
1.0
—
—
—
0
0
8
40
2.01
1.12
1.4
1.2
9.75
8.40
mm/h
—
8
40
7
32
2.20
1.08
1.3
1.2
—
—
—
0
0
12
68
1.77
1.01
1.2
1.2
—
—
—
0
0
12
68
1.77
1.01
1.2
1.2
—
—
—
0
0
43
327
1.33
0.99
1.9
2.4
13.57
12.60
nmol/l
0.26
36
299
12
69
1.75
0.96
1.5
1.3
—
—
—
0
0
11
62
1.78
0.94
1.3
1.9
1.83
2.13
u/field
—
6
32
8
42
1.91
0.88
3.6
3.4
0.56
1.44
%
—
8
42
8
43
1.87
0.87
1.1
1.1
1279.25
1557.70
miu/ml
—
8
43
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
8
44
1.83
0.86
1.0
1.1
—
—
—
0
0
42
531
0.78
0.82
1.7
1.4
37.21
30.43
iu/l
0.55
35
456
14
89
1.58
0.81
1.1
1.1
—
—
—
0
0
0
27
0.00
0.77
0.0
2.3
—
2.21
—
0
14
35
270
1.31
0.77
5.3
3.9
1.04
1.34
mmol/l
2.41
35
265
9
54
1.67
0.74
1.2
1.0
—
—
—
0
0
5
24
2.09
0.74
1.2
1.1
—
—
—
0
0
7
38
1.85
0.73
2.1
1.6
—
—
—
0
0
5
25
2.01
0.72
1.2
1.2
—
—
—
0
0
5
25
2.01
0.72
1.2
1.2
—
—
—
0
0
5
25
2.01
0.72
1.2
1.1
—
—
—
0
0
7
39
1.80
0.72
1.1
1.2
—
—
—
0
0
33
258
1.29
0.68
1.7
2.0
2214.21
6076.67
u/l
—
9
99
68
795
0.84
0.66
1.9
2.0
—
—
—
0
0
33
259
1.28
0.66
1.3
1.2
—
—
—
0
0
779
7938
0.89
0.66
5.8
6.3
38.08
39.01
mmol/mol
1.23
741
7445
42
340
1.25
0.66
1.5
1.5
—
—
—
0
0
14
95
1.48
0.64
1.1
1.1
—
—
—
0
0
44
360
1.23
0.63
1.5
1.6
5.82
12.49
u/ml
—
5
73
8
49
1.64
0.62
1.1
1.1
—
—
—
0
0
7
116
0.60
0.57
1.3
1.8
—
—
—
0
0
8
54
1.49
0.57
1.3
1.4
95.25
74.72
umol/l
—
8
54
48
402
1.20
0.57
1.7
1.4
—
—
—
0
0
170
1566
1.10
0.55
1.7
1.5
—
—
—
0
0
32
258
1.25
0.54
1.3
1.2
—
—
—
0
0
9
60
1.50
0.54
1.1
1.7
59.33
110.85
ng/l
—
9
60
40
332
1.21
0.53
1.9
1.6
0.25
0.35
mg/l
0.82
19
141
51
435
1.18
0.51
4.0
3.5
1.02
1.02
ratio
0.32
46
400
78
691
1.14
0.49
1.2
1.2
133.27
136.71
u/ml
0.02
23
283
7
108
0.65
0.49
1.0
1.5
—
—
—
0
0
7
47
1.49
0.47
1.1
1.3
—
—
—
0
0
7
47
1.49
0.47
1.1
1.3
—
—
—
0
0
68
602
1.14
0.44
2.1
3.3
4.27
4.47
pmol/l
1.01
58
535
117
1075
1.10
0.42
4.3
4.9
34.00
32.92
%
0.50
84
700
5
33
1.52
0.41
2.0
2.4
40.12
54.23
umol/l
—
5
26
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
102
933
1.10
0.40
2.4
4.3
4.10
26.09
ug/l
1.69
85
745
13
97
1.34
0.39
2.5
1.9
184.54
206.32
pmol/l
0.39
13
92
30
251
1.20
0.39
1.5
1.2
—
—
—
0
0
5
36
1.39
0.38
1.2
1.2
—
—
—
0
0
5
36
1.39
0.38
1.2
1.2
—
—
—
0
0
839
8302
1.10
0.38
5.0
5.2
4.63
4.76
mmol/l
3.58
795
7748
5
37
1.35
0.37
1.0
1.1
—
—
—
0
0
11
81
1.36
0.36
1.1
1.1
—
—
—
0
0
9
125
0.72
0.35
1.0
1.1
—
—
—
0
0
901
8957
1.15
0.33
48.2
23.1
4.35
4.44
e12/l
7.68
896
8764
7
56
1.25
0.29
1.7
1.1
—
—
—
0
0
15
182
0.82
0.26
2.1
2.3
29.47
81.81
ug/min
—
7
104
89
832
1.08
0.25
4.3
4.5
20.46
22.38
%
0.65
42
395
66
713
0.92
0.24
1.8
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
6
48
1.25
0.20
1.0
1.2
131.17
484.31
u/l
—
6
42
6
50
1.20
0.19
2.0
2.0
—
—
—
0
0
31
280
1.11
0.18
1.7
1.7
330.92
294.07
mu/l
0.32
26
254
832
8271
1.05
0.17
4.9
5.1
1.60
1.54
mmol/l
2.89
783
7675
847
8424
1.06
0.17
5.5
5.9
2.61
2.77
mmol/l
5.93
800
7844
7
62
1.13
0.17
1.6
1.9
—
—
—
0
0
47
437
1.08
0.16
1.5
1.4
—
—
—
0
0
7
86
0.81
0.14
1.1
1.2
—
—
—
0
0
7
89
0.78
0.14
1.9
2.5
1.20
1.19
mmol/l
—
7
89
7
90
0.78
0.14
1.9
2.5
106.57
105.41
mmol/l
—
7
90
300
2942
1.03
0.14
3.4
3.2
6.23
7.01
mmol/l
2.90
252
2496
20
181
1.11
0.12
1.1
1.1
0.61
1.47
u/ml
1.39
13
96
15
135
1.11
0.09
1.9
1.8
46.60
41.81
nmol/l
0.45
15
130
5
48
1.04
0.09
1.2
1.4
1.34
1.39
promille
—
5
37
290
2860
1.02
0.09
3.9
4.0
17.82
7.32
mg/mmol
1.05
161
1674
378
3738
1.02
0.09
1.9
1.9
1.27
1.34
mmol/l
1.26
314
3179
25
267
0.93
0.08
1.6
1.9
3.11
25.44
iu/l
—
9
110
5
62
0.81
0.08
1.0
1.0
422.20
336.56
ng/l
—
5
41
5
62
0.81
0.08
1.0
1.0
57.40
45.93
ng/l
—
5
41
5
62
0.81
0.08
1.0
1.0
1115.00
728.98
ng/l
—
5
40
794
7910
1.02
0.08
4.2
4.3
1.17
1.27
mmol/l
5.50
745
7260
47
451
1.04
0.07
2.0
2.0
—
—
—
0
0
104
1062
0.98
0.06
5.4
5.2
2.35
2.22
ug/l
0.08
94
949
93
911
1.02
0.05
1.5
1.7
1.53
1.41
%
0.78
75
799
65
635
1.03
0.04
3.2
3.1
0.61
0.73
ug/l
0.88
40
395
50
490
1.02
0.02
1.0
1.0
—
—
—
0
0
810
8090
1.01
0.01
4.9
5.2
5.59
5.89
mmol/l
12.80
756
7429
17
164
1.04
0.00
3.6
3.7
23.78
22.38
mg/l
—
9
111
37
372
0.99
0.00
1.7
1.9
—
—
—
0
0
18
177
1.02
0.00
5.0
1.7
0.83
0.82
nmol/l
0.02
18
148
15
145
1.04
0.00
1.1
1.0
0.32
1.75
u/ml
—
8
68
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
6.06
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
1.4
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
12
120
1.00
-0.00
1.3
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_SYSTSLCE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYSTSLCE | 2.306 [2.03, 2.62] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.224 |
During the follow-up period (1.1.1998 — 31.12.2019), 615 out of 2768 females with M13_SYSTSLCE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYSTSLCE | 2.516 [2.0, 3.17] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.068 |
During the follow-up period (1.1.1998 — 31.12.2019), 197 out of 642 males with M13_SYSTSLCE died.
Mortality risk
Mortality risk for people of age
years, who have M13_SYSTSLCE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.252% | 0.559% |
| 5 | 1.311% | 3.123% |
| 10 | 3.181% | 8.172% |
| 15 | 6.414% | 15.352% |
| 20 | 11.51% | 24.944% |
Relationships between endpoints
↥Index endpoint: M13_SYSTSLCE – Systemic sclerosis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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