scleroderma: Scleroderma is a rare autoimmune connective tissue disorder characterized by abnormal hardening of the skin and, sometimes, other organs. It is classified into two main forms: localized scleroderma and systemic sclerosis (SSc), the latter comprising three subsets; diffuse cutaneous SSc (dcSSc), limited cutaneous SSc (lcSSc) and limited SSc (lSSc) (see these terms).
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditions
|
978 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
362 |
4. Check minimum number of eventsNone |
362 |
5. Include endpointsNone |
362 |
6. Filter based on genotype QC (FinnGen only) |
333 |
Control definitions (FinnGen only)
- Control conditions
- not SYSTSCLE_ICD10
Extra metadata
- First used in FinnGen datafreeze
- DF3
Similar endpoints
↥List of similar endpoints to
Systemic sclerosis,strict definition
based on the number of shared cases.
Similar with more cases:
- Systemic sclerosis, icd10
- Systemic sclerosis
- Systemic sclerosis (FG)
- Systemic connective tissue disorders
- Reimbursement for rheumatic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1154 | 971 | 174 |
| Only index persons | 1108 | 946 | 162 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.00 |
| Only index persons | 0.03 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 56.01 | 56.13 | 55.70 |
| Only index persons | 55.73 | 55.79 | 55.39 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 333 | 286 | 47 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.02 |
| Median age at first event (years) | 55.07 | 54.41 | 59.07 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 346
- Matched controls
- 3460
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
+∞
307.7
346
248
M34.1
ICD-10 Finland
CR(E)ST syndrome
+∞
307.7
261
*
C08CA05
ATC
nifedipine; systemic
49.1
278.9
187
81
P01BA02
ATC
hydroxychloroquine; oral
32.6
252.5
227
191
L04AX03
ATC
methotrexate; systemic
27.6
229.2
230
232
I73.0
ICD-10 Finland
Raynaud syndrome
64.1
219.8
127
31
XX9XE
NOMESCO Finland
Other ultrasound examination
136.6
207.8
105
11
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
2987.0
183.5
161
*
L04AA06
ATC
mycophenolic acid; systemic
50.0
157.9
95
26
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
18.2
116.4
106
82
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
12.6
103.5
124
147
G04BE03
ATC
sildenafil; oral
65.2
98.5
55
10
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
35.8
95.6
62
21
L88
ICPC
Rheumatoid/seropositive arthritis
14.6
87.5
88
79
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
9.0
82.5
134
228
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
14.6
81.4
81
71
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
12.1
73.5
83
88
M34.0
ICD-10 Finland
Progressive systemic sclerosis
+∞
68.0
63
*
L04AX01
ATC
azathioprine; systemic
13.6
66.0
67
60
XPX04
NOMESCO Finland
Angioscopy
363.3
61.4
60
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.6
56.3
205
715
C08CA02
ATC
felodipine; oral
8.4
55.3
83
125
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
+∞
49.1
46
*
QC6S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in hand
+∞
48.0
45
*
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
15.1
47.7
44
33
R4120
NOMESCO Finland
Occupational therapy
7.3
45.6
77
131
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
4.8
44.4
155
504
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.2
43.6
256
1226
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
12.1
40.8
43
40
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
12.8
39.4
40
35
XG410
NOMESCO Finland
Flow-volume spirometry
9.1
36.8
48
60
GD1AD
NOMESCO Finland
Thorax CT examination
6.8
35.3
61
105
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
5.2
34.2
83
197
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
367.6
33.5
33
*
NH3EA
NOMESCO Finland
Feet X-ray examination with load
11.7
31.8
34
32
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.6
29.4
84
226
L04AD01
ATC
ciclosporin; systemic
11.2
25.7
28
27
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.6
24.3
66
169
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
9.0
23.5
30
36
M34
ICD-10 Finland
Systemic sclerosis
+∞
23.2
22
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.6
23.1
97
339
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
35.0
22.8
29
9
H02AB06
ATC
prednisolone; systemic
3.1
22.0
223
1288
L01BA01
ATC
methotrexate; systemic
7.0
21.8
35
55
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.5
21.2
58
149
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
7.7
20.7
30
42
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.9
20.4
179
945
C08CA01
ATC
amlodipine; oral
2.8
20.3
170
876
J99.1*M34.8
ICD-10 Finland
Respiratory disorders in systemic: sclerosis
+∞
20.0
19
*
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
4.0
18.6
58
164
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
19.4
18.1
27
15
C02KX04
ATC
macitentan; oral
+∞
17.9
17
*
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
66.8
16.9
19
*
RT172, ,
NOMESCO Finland
94.7
16.7
18
*
E0000UV, ,
ATC
2.5
16.2
195
1164
RT160, ,
NOMESCO Finland
+∞
15.7
15
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
6.9
15.1
24
37
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
16.0
15.1
24
16
Z01.8
ICD-10 Finland
Other specified special examinations
2.7
15.0
112
529
RT274, ,
NOMESCO Finland
83.7
14.7
16
*
C02KX01
ATC
bosentan; oral
+∞
14.7
14
*
K22.4
ICD-10 Finland
Dyskinesia of oesophagus
28.6
14.4
19
7
L03.0
ICD-10 Finland
Cellulitis of finger and toe
3.4
13.6
55
184
WZA10
NOMESCO Finland
Extensive medical or dental certificate
11.6
13.2
24
22
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.4
13.2
52
171
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
4.3
13.0
35
88
L04AA01
ATC
[U] ciclosporin
18.2
12.7
19
11
G73.7*M34.8
ICD-10 Finland
Myopathy in scleroderma
134.7
12.5
13
*
M35.1
ICD-10 Finland
Other overlap syndromes
27.8
12.2
16
6
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
10.2
11.9
23
24
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.3
11.9
48
160
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.4
11.0
100
508
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
4.3
10.9
29
72
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.1
10.8
188
1237
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
11.8
10.7
19
17
A02BC02
ATC
pantoprazole; systemic
2.4
10.7
271
2069
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.1
10.2
45
158
S09
ICPC
Infected finger/toe
4.7
10.2
24
54
UJF30
NOMESCO Finland
Ileoscopy through colon
2.8
9.7
55
222
RT271, ,
NOMESCO Finland
56.6
9.7
11
*
I27.0
ICD-10 Finland
Primary pulmonary hypertension
102.7
9.5
10
*
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.7
9.3
30
86
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
4.5
9.3
23
54
R06.0
ICD-10 Finland
Dyspnoea
2.1
9.0
115
664
A02BC05
ATC
esomeprazole; systemic
2.0
8.9
171
1142
R15
ICD-10 Finland
Faecal incontinence
4.3
8.9
23
56
UJF32
NOMESCO Finland
Coloscopy
2.1
8.5
106
604
PB1BC
NOMESCO Finland
Extensive angiography of upper extremity with X-ray
92.2
8.5
9
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.4
8.4
66
311
PHD76
NOMESCO Finland
Resection of long saphenous vein
3.5
8.4
29
87
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.3
8.4
75
374
I73.1
ICD-10 Finland
Thromboangiitis obliterans [Buerger]
+∞
8.4
8
*
I27.8
ICD-10 Finland
Other specified pulmonary heart diseases
+∞
8.4
8
*
J01FF01
ATC
clindamycin; systemic
2.0
8.2
114
674
C03CA01
ATC
furosemide; systemic
2.1
8.1
95
528
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
7.2
7.9
18
26
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
9.7
7.9
15
16
K22.1
ICD-10 Finland
Ulcer of oesophagus
12.2
7.6
13
11
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
4.6
7.5
18
41
S97
ICPC
Chronic ulcer skin
3.2
7.5
30
99
C08DB01
ATC
diltiazem; oral
3.9
7.5
22
59
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
3.0
7.4
33
116
SPAT1263
SPAT
Sampling
1.9
7.3
161
1102
G04BE08
ATC
tadalafil; oral
+∞
7.3
7
*
XQ860
NOMESCO Finland
Laser Doppler measurement/scan of capillary perfusion
+∞
7.3
7
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.0
7.3
32
112
XJC02
NOMESCO Finland
Mesurement of oesophageal pressure and pressure profile of lower oesophageal sphincter
30.7
7.2
9
*
RT310, ,
NOMESCO Finland
30.7
7.2
9
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
7.1
78
420
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.3
7.1
58
277
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.0
7.1
33
119
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.4
7.1
18
43
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.7
7.1
41
167
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
7.0
162
1123
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.2
6.8
65
331
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
9.6
6.8
13
14
S18
ICPC
Laceration/cut
1.8
6.8
178
1277
RT231, ,
NOMESCO Finland
40.9
6.8
8
*
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
7.4
6.8
15
21
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
6.7
55
263
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
3.7
6.7
21
59
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.7
6.6
36
142
J96.1
ICD-10 Finland
Chronic respiratory failure
7.1
6.6
15
22
RT272, ,
NOMESCO Finland
14.7
6.4
10
7
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.4
6.4
47
215
K62.3
ICD-10 Finland
Rectal prolapse
7.2
6.3
14
20
L94.3
ICD-10 Finland
Sclerodactyly
+∞
6.3
6
*
M43.9
ICD-10 Finland
Deforming dorsopathy, unspecified
+∞
6.3
6
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.5
6.3
40
171
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
5.5
6.2
17
32
SPAT1249
SPAT
Treatment-related counselling outside office
1.8
6.2
146
1007
H04.10
ICD-10 Finland
Dry eye syndrome
2.1
6.1
62
324
R13
ICD-10 Finland
Dysphagia
2.6
6.0
35
143
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
184
98
38.96
252.41
1.7
1.3
23.30
0.96
u/ml
—
30
5
182
122
30.36
223.98
1.7
1.3
2.30
2.52
u/ml
0.11
56
14
182
123
30.11
223.05
1.7
1.3
6.04
6.85
u/ml
0.07
80
24
185
132
28.97
220.74
1.6
1.2
2.57
3.04
u/ml
—
11
9
150
104
24.70
178.67
1.7
1.3
0.46
—
u/ml
—
5
0
144
101
23.71
169.99
1.6
1.2
25.11
49.71
u/ml
0.66
29
16
167
172
17.83
158.17
2.6
1.8
5.08
4.45
iu/ml
0.20
59
40
306
872
22.70
128.65
6.3
3.2
570.44
859.64
ng/l
1.82
290
740
84
40
27.41
115.72
1.2
1.3
—
—
—
0
0
235
543
11.37
115.31
1.9
1.4
2156.32
435.56
titre
25.09
174
126
132
163
12.48
107.25
1.8
1.2
8.21
1.22
u/ml
—
16
9
58
12
57.87
101.42
3.0
1.2
8.34
8.93
ug/l
0.18
58
12
57
21
32.30
85.35
1.2
1.1
—
—
—
0
0
338
1697
43.82
84.71
16.9
6.3
1.62
1.96
e9/l
4.97
329
1503
338
1731
42.13
81.93
17.2
6.6
0.19
0.18
e9/l
0.90
330
1523
58
32
21.57
74.09
1.3
1.3
—
—
—
0
0
58
32
21.57
74.09
1.3
1.3
—
—
—
0
0
58
33
20.91
73.04
1.3
1.2
—
—
—
0
0
58
33
20.91
73.04
1.3
1.2
—
—
—
0
0
337
1853
32.46
71.59
20.2
9.8
3.70
3.97
e9/l
2.19
328
1620
58
36
19.15
70.03
1.3
1.2
—
—
—
0
0
61
42
17.42
69.91
1.4
1.2
8.73
72.20
u/ml
—
11
5
239
970
5.73
53.96
3.2
2.2
92.06
147.77
u/l
5.46
232
929
312
1736
9.11
44.87
6.5
3.8
18.51
8.15
estimate
0.23
74
372
310
1722
8.69
44.44
6.6
3.8
0.00
0.00
estimate
-0.00
73
362
311
1761
8.57
42.76
6.6
3.9
0.00
0.02
estimate
0.80
74
355
193
803
4.17
38.36
3.5
2.6
314.89
319.57
umol/l
0.27
188
707
338
2443
17.58
36.85
16.7
8.1
73.40
77.80
u/l
1.69
338
2310
50
76
7.52
32.40
1.8
1.9
124.33
128.97
g/l
0.47
18
58
52
97
6.13
27.58
1.5
1.6
0.01
0.08
iu/ml
—
5
9
190
977
3.10
23.70
7.2
3.9
0.00
0.00
estimate
-0.00
72
354
245
1479
3.25
22.56
22.4
10.7
0.00
0.00
e9/l
0.09
226
1219
250
1528
3.29
22.51
3.5
2.6
79.78
78.36
nmol/l
0.40
244
1388
33
21
17.24
21.04
1.2
1.1
—
—
—
0
0
25
6
44.77
20.74
1.0
1.2
—
—
—
0
0
154
765
2.83
19.51
1.3
1.3
25.02
34.26
iu/ml
0.66
62
244
25
11
24.37
18.01
1.0
1.3
—
—
—
0
0
241
1574
2.75
16.81
9.4
6.7
1.21
1.22
mmol/l
1.56
218
1359
220
1418
2.51
15.04
8.4
5.9
1.21
1.22
mmol/l
0.76
212
1317
27
53
5.44
13.39
1.4
1.1
3.92
1.44
u/ml
0.46
13
18
107
523
2.51
13.09
3.1
2.6
0.91
1.07
e6/l
0.31
83
263
126
664
2.41
13.07
3.3
2.6
4.31
7.05
e6/l
1.10
118
609
203
1314
2.32
12.99
6.7
3.6
0.09
0.01
estimate
0.63
69
300
35
93
4.07
12.06
2.5
2.4
—
—
—
0
0
95
461
2.46
11.64
2.7
1.9
—
—
—
0
0
26
56
4.94
11.62
1.3
1.1
5.12
3.95
u/ml
0.13
17
22
137
783
2.24
11.47
3.8
2.2
3.20
2.87
mg/l
0.79
130
670
145
855
2.20
11.18
3.8
2.9
0.15
0.36
e6/l
2.02
126
597
124
709
2.17
10.14
1.3
1.3
3.33
9.68
u/ml
1.88
47
281
23
51
4.76
9.93
1.3
1.4
—
—
—
0
0
72
339
2.42
9.25
2.5
1.8
—
—
—
0
0
340
3095
6.68
9.05
31.5
14.4
18.54
21.62
mg/l
1.02
293
2500
26
71
3.88
8.62
1.5
1.4
—
—
—
0
0
66
310
2.40
8.49
11.9
7.5
0.07
1.09
mmol/l
1.46
56
265
17
20
8.88
8.40
2.1
2.1
—
—
—
0
0
123
745
2.01
8.33
7.7
3.9
1.02
1.02
kg/l
0.08
99
487
66
324
2.28
7.63
2.6
1.9
—
—
—
0
0
15
17
9.17
7.62
1.5
1.0
—
—
—
0
0
19
33
6.03
7.33
1.9
1.7
—
—
—
0
0
49
215
2.49
7.27
2.5
1.5
—
—
—
0
0
17
39
4.53
7.04
1.1
1.1
—
—
—
0
0
90
514
2.01
7.03
4.5
3.6
0.82
0.82
mmol/l
0.11
83
491
37
144
2.76
6.96
5.0
3.6
1.50
1.72
mmol/l
0.16
25
107
163
1136
1.82
6.89
2.9
3.4
2.35
2.36
mmol/l
0.83
157
1038
60
306
2.16
6.28
3.7
4.3
287.73
275.12
u/l
0.14
60
289
21
62
3.54
6.24
2.3
1.7
—
—
—
0
0
141
964
1.78
6.18
4.4
3.2
0.00
0.00
estimate
0.50
69
293
28
100
2.96
6.16
3.8
2.5
24.26
24.70
mmol/l
0.28
28
100
30
112
2.84
6.10
2.0
2.0
1.77
1.60
g/l
0.41
24
97
162
1160
1.75
6.00
5.4
3.5
32.13
81.18
ng/l
0.44
114
761
19
54
3.66
5.97
2.2
1.8
—
—
—
0
0
26
93
2.94
5.71
1.4
1.1
—
—
—
0
0
46
219
2.27
5.68
6.8
7.5
8.23
8.33
mmol/l
0.03
46
210
13
20
6.71
5.61
1.3
1.2
—
—
—
0
0
33
138
2.54
5.41
2.0
1.6
—
—
—
0
0
17
48
3.67
5.39
2.2
1.8
—
—
—
0
0
16
34
4.88
5.37
1.7
1.3
—
—
—
0
0
9
8
11.51
5.32
1.8
1.3
—
—
—
0
0
215
1701
1.70
5.26
7.6
6.5
9.35
10.14
umol/l
1.15
202
1626
19
60
3.29
5.12
2.3
1.7
—
—
—
0
0
21
72
3.04
4.96
2.3
1.7
—
—
—
0
0
18
57
3.28
4.83
3.7
2.4
13.78
16.31
%
1.67
18
57
96
624
1.75
4.82
2.4
2.6
2.44
2.45
mmol/l
0.34
91
570
22
79
2.91
4.81
4.0
2.9
7.06
8.22
kpa
1.51
22
79
22
79
2.91
4.81
1.6
1.4
—
—
—
0
0
23
87
2.76
4.59
2.2
1.7
—
—
—
0
0
23
87
2.76
4.59
2.3
1.8
—
—
—
0
0
20
70
2.97
4.57
1.1
2.0
—
—
—
0
0
25
100
2.62
4.49
1.2
1.2
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
19
66
2.99
4.40
2.7
2.3
0.49
0.40
iu/ml
0.31
12
36
65
388
1.83
4.31
12.4
6.4
103.94
104.30
mmol/l
0.24
65
388
7
6
11.87
4.29
3.1
2.0
1.03
1.24
ratio
—
7
6
16
51
3.24
4.26
1.2
1.1
98.25
118.51
%
2.19
16
45
48
263
1.96
4.12
2.5
2.5
30.12
21.79
au/ml
—
9
21
109
762
1.63
4.08
2.0
1.7
1.20
1.05
mg/l
0.31
90
601
74
468
1.74
4.03
1.7
1.7
1170.54
1195.55
nmol/l
0.09
65
340
50
280
1.92
4.03
2.6
2.5
64.85
68.44
ml/min/173m2
0.29
26
122
172
1343
1.56
4.00
13.5
10.4
1.21
1.14
inr
1.06
147
1098
71
445
1.75
3.99
3.7
2.3
21.21
22.36
%
0.17
65
415
13
32
4.18
3.94
1.1
1.5
—
—
—
0
0
14
37
3.90
3.94
1.1
1.2
—
—
—
0
0
14
38
3.79
3.84
1.1
1.1
—
—
—
0
0
46
255
1.93
3.82
1.5
1.5
—
—
—
0
0
16
55
3.00
3.79
1.2
1.0
—
—
—
0
0
87
588
1.64
3.68
4.6
3.7
226.39
315.45
ng/l
0.23
67
417
14
40
3.60
3.65
1.2
1.0
88.50
102.88
%
1.01
14
33
173
1372
1.52
3.63
2.2
2.0
99.09
99.79
pmol/l
0.06
97
680
117
853
1.56
3.60
1.3
1.3
0.51
1.68
u/ml
1.52
31
250
243
2077
1.57
3.58
5.2
4.6
—
158.64
—
0
28
17
63
2.79
3.54
1.1
1.3
—
—
—
0
0
38
204
1.97
3.47
2.7
2.4
28.14
7.68
ug/l
0.44
31
179
11
27
4.17
3.42
1.2
1.7
—
—
—
0
0
11
27
4.17
3.42
1.2
1.7
—
—
—
0
0
11
27
4.17
3.42
1.2
1.7
—
—
—
0
0
29
143
2.12
3.32
1.8
1.3
—
—
—
0
0
198
1639
1.49
3.24
4.4
3.0
105.33
91.96
ug/l
0.31
191
1536
23
104
2.30
3.23
3.2
1.9
101.22
97.35
%
0.51
23
98
8
15
5.43
3.21
2.0
4.5
1037.63
1178.47
mg
—
8
15
23
105
2.28
3.17
1.9
1.9
—
—
—
0
0
20
86
2.41
3.14
3.5
4.1
30.97
25.21
mg/l
0.36
15
69
20
86
2.41
3.14
3.4
4.1
80.07
37.19
mg/l
0.57
15
71
11
31
3.63
3.02
1.9
1.9
—
—
—
0
0
5
5
10.12
2.99
3.2
6.6
4.86
5.40
kpa
—
5
5
5
5
10.12
2.99
4.8
6.8
5.08
5.76
kpa
—
5
5
8
17
4.79
2.93
3.1
1.5
—
—
—
0
0
8
17
4.79
2.93
3.1
1.5
—
—
—
0
0
8
18
4.52
2.81
3.3
1.4
—
—
—
0
0
7
14
5.08
2.74
1.0
1.1
10.29
13.71
u/l
—
7
14
24
119
2.09
2.73
1.4
1.8
2.80
2.98
g/l
0.39
24
112
324
3042
2.02
2.69
24.9
13.9
82.54
83.23
ml/min/173m2
0.27
315
2811
22
106
2.15
2.69
1.3
1.7
10.68
9.96
g/l
0.32
22
98
8
19
4.28
2.69
1.6
2.0
76.07
55.54
ug/l
—
8
19
11
35
3.21
2.67
1.9
1.8
—
—
—
0
0
18
80
2.32
2.65
1.7
1.5
—
—
—
0
0
21
100
2.17
2.64
1.8
1.7
—
—
—
0
0
289
2633
1.59
2.64
37.1
18.1
14.30
13.54
%
16.24
289
2609
209
1788
1.43
2.63
7.6
4.6
6.19
6.50
mmol/l
2.28
201
1690
286
2603
1.57
2.59
5.2
4.9
15.23
14.67
pmol/l
3.36
273
2420
12
42
2.92
2.57
2.9
1.6
—
—
—
0
0
6
11
5.53
2.55
1.0
2.1
—
—
—
0
0
6
11
5.53
2.55
1.0
2.1
—
—
—
0
0
6
11
5.53
2.55
1.0
2.1
—
—
—
0
0
17
75
2.33
2.55
2.9
3.2
1.67
1.33
index
—
6
43
137
1093
1.42
2.53
4.4
3.2
29.18
28.46
u/l
0.20
131
1034
117
908
1.44
2.52
1.9
1.6
22.23
21.50
nmol/l
0.20
108
754
17
76
2.30
2.48
2.6
3.8
14.61
2.44
ratio
—
8
41
24
125
1.99
2.42
1.4
1.8
3.14
3.66
g/l
2.14
24
118
24
125
1.99
2.42
1.4
1.8
7.16
7.54
g/l
0.61
24
118
24
125
1.99
2.42
1.4
1.8
3.96
4.45
g/l
1.95
24
118
7
17
4.18
2.37
1.0
1.8
—
—
—
0
0
7
17
4.18
2.37
1.0
1.8
—
—
—
0
0
7
17
4.18
2.37
1.0
1.8
—
—
—
0
0
7
17
4.18
2.37
1.0
1.8
—
—
—
0
0
54
362
1.58
2.34
9.6
5.8
—
—
—
0
0
8
23
3.54
2.28
3.0
1.5
—
—
—
0
0
28
159
1.83
2.21
1.5
1.5
—
—
—
0
0
22
116
1.96
2.16
1.8
1.4
262.05
311.46
ug/g
0.40
11
70
15
68
2.26
2.14
1.9
1.5
—
—
—
0
0
234
2079
1.39
2.14
3.3
3.2
—
—
—
0
0
14
62
2.31
2.10
1.5
1.4
—
—
—
0
0
99
768
1.40
2.09
3.9
2.2
—
—
—
0
0
11
45
2.49
1.95
2.5
1.6
—
—
—
0
0
16
79
2.08
1.88
1.3
1.2
3.21
3.75
mmol/l
1.04
16
73
123
1004
1.35
1.88
2.8
2.5
59.74
60.72
u/l
0.06
113
929
18
96
1.92
1.74
1.2
1.8
0.00
0.05
g/l
0.49
18
91
8
30
2.71
1.73
2.6
3.7
—
—
—
0
0
20
111
1.85
1.72
1.5
2.0
1.27
0.64
g/l
0.27
20
101
19
104
1.87
1.71
1.2
2.9
11.39
10.68
mg/l
0.15
19
96
41
282
1.51
1.62
3.8
3.4
0.49
2.06
mmol/l
1.43
35
245
314
2990
1.54
1.54
6.5
5.9
2.01
1.85
mu/l
1.69
304
2793
0
44
0.00
1.52
0.0
1.6
—
—
—
0
0
13
66
2.01
1.45
2.2
2.9
7.89
7.88
pmol/l
0.00
13
66
5
16
3.15
1.44
1.2
1.6
—
—
—
0
0
5
16
3.15
1.44
1.2
1.1
—
—
—
0
0
6
22
2.76
1.44
1.2
1.1
214.83
763.60
u/l
—
6
22
18
104
1.77
1.40
1.4
1.2
—
—
—
0
0
5
18
2.80
1.29
1.2
1.2
6.40
8.56
mm/h
—
5
18
11
55
2.03
1.28
1.6
1.3
—
—
—
0
0
11
55
2.03
1.28
1.6
1.3
—
—
—
0
0
5
19
2.65
1.22
1.6
4.7
859.40
479.05
u/ml
—
5
19
20
125
1.64
1.20
1.3
1.4
201.00
253.91
miu/ml
—
8
55
48
362
1.38
1.20
1.6
2.8
4.63
5.93
umol/l
1.15
40
313
23
150
1.57
1.18
1.9
1.6
—
—
—
0
0
59
464
1.33
1.14
4.0
2.8
6.21
3.70
e6/l
0.47
34
204
25
172
1.49
1.03
4.3
3.1
22.52
24.59
mmol/l
1.88
25
172
11
61
1.83
0.99
1.2
1.4
225.00
225.35
u/ml
—
6
34
26
361
0.70
0.98
1.2
1.8
1.47
1.39
%
0.25
20
318
167
1511
1.20
0.95
3.7
2.6
—
—
estimate
—
0
0
76
637
1.25
0.91
1.5
1.7
469.10
9470148.57
pmol/l
0.50
69
528
6
29
2.09
0.89
2.2
1.1
88.50
102.93
pmol/l
—
6
29
8
42
1.93
0.89
1.5
1.3
—
—
—
0
0
8
42
1.93
0.89
1.5
1.3
—
—
—
0
0
16
103
1.58
0.89
1.7
1.2
—
—
—
0
0
16
104
1.56
0.86
1.6
1.2
—
—
—
0
0
25
180
1.42
0.84
1.8
1.4
—
—
—
0
0
11
66
1.69
0.79
1.2
1.4
—
—
—
0
0
5
24
2.10
0.75
1.0
1.2
—
—
—
0
0
5
25
2.01
0.73
2.0
2.5
—
—
—
0
0
85
740
1.20
0.71
1.5
1.5
—
—
—
0
0
7
41
1.72
0.70
1.6
1.3
—
—
—
0
0
7
41
1.72
0.70
1.6
1.3
—
—
—
0
0
30
383
0.76
0.70
1.6
2.0
—
—
—
0
0
7
42
1.68
0.69
1.6
1.3
—
—
—
0
0
7
42
1.68
0.69
1.6
1.3
—
—
—
0
0
22
165
1.36
0.62
3.8
2.6
0.63
0.61
%
0.15
22
165
22
288
0.75
0.62
1.4
1.9
3.27
3.52
mmol/l
0.61
16
225
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
2.0
—
7.23
—
0
20
30
374
0.78
0.59
1.7
2.1
3.05
3.30
ratio
0.79
22
310
22
167
1.34
0.58
3.9
2.7
1.01
1.23
%
0.91
22
167
91
1011
0.86
0.55
4.1
4.0
18.87
7.78
mg/mmol
0.71
51
570
6
39
1.55
0.53
1.2
1.2
—
—
—
0
0
6
39
1.55
0.53
1.2
1.2
—
—
—
0
0
304
2965
1.21
0.51
4.1
4.3
1.14
1.26
mmol/l
3.15
287
2747
37
309
1.22
0.49
4.8
3.2
—
—
—
0
0
23
183
1.28
0.46
16.3
7.3
24.12
25.09
mmol/l
0.77
23
183
308
3018
1.19
0.42
4.5
5.0
5.59
5.83
mmol/l
4.77
292
2801
0
15
0.00
0.41
0.0
2.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
43.87
—
0
15
29
342
0.83
0.38
2.0
4.2
3.31
19.87
ug/l
0.73
23
280
316
3109
1.19
0.36
4.7
5.0
1.60
1.56
mmol/l
0.87
302
2898
25
295
0.84
0.33
1.2
1.3
24.14
166.19
u/ml
—
7
128
14
175
0.79
0.31
1.7
1.8
—
—
—
0
0
30
346
0.85
0.31
1.4
1.9
—
—
—
0
0
135
1420
0.92
0.30
1.7
2.0
1.25
1.36
mmol/l
0.97
119
1208
291
2958
0.90
0.27
5.2
6.0
37.11
38.64
mmol/mol
3.24
279
2795
45
406
1.12
0.27
4.5
4.8
33.89
32.95
%
0.23
37
258
13
105
1.25
0.25
1.3
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
319
3157
1.13
0.21
5.3
5.9
2.60
2.83
mmol/l
5.09
306
2948
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
12
0.00
0.21
0.0
1.0
—
146.92
—
0
12
0
12
0.00
0.21
0.0
1.0
—
105.33
—
0
6
0
12
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
120.57
—
0
7
73
687
1.08
0.20
1.7
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
1905.36
—
0
14
315
3118
1.11
0.19
4.9
5.2
4.63
4.84
mmol/l
3.29
303
2919
19
214
0.88
0.16
2.0
1.9
—
—
—
0
0
10
83
1.21
0.15
1.0
1.1
—
8.48
—
0
13
214
2180
0.95
0.15
3.9
3.2
54.06
42.69
u/l
1.30
200
2067
8
97
0.82
0.14
1.0
1.1
—
4.99
—
0
15
9
108
0.83
0.13
1.3
1.2
—
—
—
0
0
17
154
1.11
0.10
1.9
1.5
—
—
—
0
0
25
269
0.92
0.10
3.1
4.4
21.44
22.51
%
0.16
12
129
6
56
1.07
0.08
4.2
1.4
0.73
0.96
nmol/l
—
6
46
19
179
1.07
0.05
1.0
1.0
—
—
—
0
0
12
127
0.94
0.01
1.1
1.3
0.87
0.90
g/l
0.21
12
127
15
143
1.05
0.01
1.5
1.4
0.22
0.30
mg/l
—
7
51
12
122
0.98
0.00
1.1
1.2
1.49
1.63
g/l
1.22
12
122
10
103
0.97
0.00
1.4
1.2
—
—
—
0
0
20
204
0.98
0.00
2.0
2.9
0.55
0.81
ug/l
1.24
13
127
0
5
0.00
0.00
0.0
1.0
—
52.40
—
0
5
0
5
0.00
0.00
0.0
1.6
—
6.06
—
0
5
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
0.67
—
0
6
0
5
0.00
0.00
0.0
1.4
—
1.20
—
0
5
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
75.60
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
409.80
—
0
5
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
108.50
—
0
6
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint SYSTSCLE_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SYSTSCLE_STRICT | 2.104 [1.69, 2.63] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.582 |
During the follow-up period (1.1.1998 — 31.12.2019), 108 out of 823 females with SYSTSCLE_STRICT died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have SYSTSCLE_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.201% | No data |
| 5 | 1.155% | No data |
| 10 | 3.086% | No data |
| 15 | 6.121% | No data |
| 20 | 10.651% | No data |
Relationships between endpoints
↥Index endpoint: SYSTSCLE_STRICT – Systemic sclerosis,strict definition
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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