No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
613 |
4. Check minimum number of eventsNone |
613 |
5. Include endpointsNone |
613 |
6. Filter based on genotype QC (FinnGen only) |
564 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M34
- Name in latin
- Syndroma CREST
Similar endpoints
↥List of similar endpoints to
CR(E)ST syndrome
based on the number of shared cases.
Similar with more cases:
- Systemic sclerosis, icd10
- Systemic sclerosis (FG)
- Systemic sclerosis
- Systemic connective tissue disorders
- Autoimmune diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2272 | 1946 | 313 |
| Only index persons | 2112 | 1834 | 278 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.01 |
| Only index persons | 0.06 | 0.07 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.34 | 58.28 | 59.14 |
| Only index persons | 57.94 | 57.80 | 58.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 564 | 494 | 70 |
| Unadjusted period prevalence (%) | 0.16 | 0.18 | 0.03 |
| Median age at first event (years) | 57.99 | 57.82 | 59.22 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 585
- Matched controls
- 5850
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
29.3
307.7
404
414
P01BA02
ATC
hydroxychloroquine; oral
24.0
307.7
349
340
I73.0
ICD-10 Finland
Raynaud syndrome
67.6
307.7
192
42
M34.1
ICD-10 Finland
CR(E)ST syndrome
+∞
307.7
585
*
C08CA05
ATC
nifedipine; systemic
38.1
307.7
294
151
XX9XE
NOMESCO Finland
Other ultrasound examination
84.9
246.8
132
20
L04AX03
ATC
methotrexate; systemic
13.2
214.8
279
378
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
401.4
178.7
171
6
L04AA06
ATC
mycophenolic acid; systemic
36.5
178.1
115
39
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
38.7
170.8
108
34
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
14.0
146.6
152
143
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
10.8
144.8
190
250
G04BE03
ATC
sildenafil; oral
74.8
143.8
78
12
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
8.4
124.3
209
365
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
10.9
86.5
101
110
L88
ICPC
Rheumatoid/seropositive arthritis
9.2
83.6
113
149
M34.0
ICD-10 Finland
Progressive systemic sclerosis
451.6
81.0
79
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.9
80.0
343
1314
XPX04
NOMESCO Finland
Angioscopy
231.1
79.4
80
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
8.2
79.4
118
174
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
4.6
72.6
269
908
L04AX01
ATC
azathioprine; systemic
9.5
69.9
89
108
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
10.7
65.3
75
79
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
702.2
65.2
63
*
C08CA02
ATC
felodipine; oral
5.8
60.8
129
271
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.3
58.4
419
2168
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
10.6
56.7
65
68
R4120
NOMESCO Finland
Occupational therapy
5.8
53.5
110
223
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
4.8
52.9
144
372
QC6S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in hand
+∞
52.9
50
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.5
46.5
137
374
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
5.1
46.4
111
256
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
16.4
46.4
40
26
XG410
NOMESCO Finland
Flow-volume spirometry
7.7
45.9
68
98
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
9.8
45.8
55
61
GD1AD
NOMESCO Finland
Thorax CT examination
5.6
44.0
92
188
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
9.9
42.8
51
56
NH3EA
NOMESCO Finland
Feet X-ray examination with load
8.8
41.2
54
67
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.5
38.8
169
601
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
391.0
37.4
37
*
A05AA02
ATC
ursodeoxycholic acid; oral
11.2
36.1
39
37
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
11.9
35.7
37
33
L01BA01
ATC
methotrexate; systemic
6.4
33.7
59
101
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
10.9
33.7
37
36
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
8.1
33.1
46
61
M35.1
ICD-10 Finland
Other overlap syndromes
38.9
31.9
40
11
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
7.5
31.8
47
67
M34
ICD-10 Finland
Systemic sclerosis
329.7
31.1
31
*
C08CA01
ATC
amlodipine; oral
2.7
30.5
304
1674
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
28.9
28.3
38
14
H02AB06
ATC
prednisolone; systemic
2.6
27.9
361
2225
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
4.3
26.9
75
193
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
26.8
308
1784
L04AD01
ATC
ciclosporin; systemic
9.6
26.7
32
35
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.6
26.0
96
301
K74.3
ICD-10 Finland
Primary biliary cirrhosis
30.0
25.7
34
12
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
3.5
24.4
94
303
C02KX01
ATC
bosentan; oral
+∞
23.1
22
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
6.4
22.8
39
65
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
47.0
22.5
27
6
C02KX04
ATC
macitentan; oral
+∞
22.0
21
*
R06.0
ICD-10 Finland
Dyspnoea
2.4
21.8
218
1158
K62.3
ICD-10 Finland
Rectal prolapse
8.6
21.5
28
34
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.3
20.9
346
2265
SBA10
NOMESCO Finland
Measurement of salivary flow rate
9.0
20.8
26
30
WZA10
NOMESCO Finland
Extensive medical or dental certificate
8.5
19.8
26
32
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
19.3
184
949
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
7.2
19.3
29
42
TGC00
NOMESCO Finland
Bronchial lavation
5.9
19.2
35
62
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
4.2
18.7
53
137
L03.0
ICD-10 Finland
Cellulitis of finger and toe
3.2
18.7
83
290
RT172, ,
NOMESCO Finland
103.4
18.7
20
*
RT160, ,
NOMESCO Finland
196.0
18.6
19
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.1
18.6
87
314
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.0
18.4
90
333
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
18.1
177
919
M01CC01
ATC
penicillamine; oral
98.1
17.7
19
*
J01FF01
ATC
clindamycin; systemic
2.2
17.5
208
1168
E0000UV, ,
ATC
2.1
16.9
303
1987
J99.1*M34.8
ICD-10 Finland
Respiratory disorders in systemic: sclerosis
+∞
16.7
16
*
R15
ICD-10 Finland
Faecal incontinence
4.2
16.2
44
110
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
7.3
16.2
24
34
RT274, ,
NOMESCO Finland
49.0
16.1
19
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.0
15.9
75
271
K22.4
ICD-10 Finland
Dyskinesia of oesophagus
17.8
15.7
24
14
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.3
15.3
60
194
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.0
15.1
73
267
L04AA01
ATC
[U] ciclosporin
12.3
14.7
26
22
A02BC02
ATC
pantoprazole; systemic
2.2
14.7
454
3559
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
14.6
100
439
S09
ICPC
Infected finger/toe
4.3
14.2
38
94
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.3
14.1
37
90
H04.10
ICD-10 Finland
Dry eye syndrome
2.4
14.0
116
554
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
3.9
14.0
43
118
D06BX01
ATC
metronidazole; topical
2.5
13.9
102
462
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
13.8
277
1848
XJC02
NOMESCO Finland
Mesurement of oesophageal pressure and pressure profile of lower oesophageal sphincter
26.5
13.4
18
7
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.6
13.2
81
336
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.4
12.9
48
150
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
14.5
12.8
21
15
UJF30
NOMESCO Finland
Ileoscopy through colon
2.5
12.7
92
413
R4190
NOMESCO Finland
Nutritional therapy
3.9
12.6
38
103
G73.7*M34.8
ICD-10 Finland
Myopathy in scleroderma
132.7
12.5
13
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
4.8
12.2
28
61
K22.7
ICD-10 Finland
Barrett oesophagus
10.4
12.1
23
23
A06AC01
ATC
ispaghula (psylla seeds); oral
1.9
11.9
203
1268
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
3.0
11.8
55
197
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
5.4
11.6
23
44
B80
ICPC
Iron deficiency anaemia
5.0
11.5
25
52
XQ860
NOMESCO Finland
Laser Doppler measurement/scan of capillary perfusion
+∞
11.5
11
*
L95
ICPC
Osteoporosis
3.2
11.3
47
157
RT271, ,
NOMESCO Finland
35.8
11.3
14
*
UJF32
NOMESCO Finland
Coloscopy
1.9
11.2
180
1100
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
14.2
11.0
18
13
M05BX04
ATC
denosumab; parenteral
2.8
11.0
58
222
I27.0
ICD-10 Finland
Primary pulmonary hypertension
44.2
11.0
13
*
RT310, ,
NOMESCO Finland
44.2
11.0
13
*
GD2SN
NOMESCO Finland
Lung ventilation SPECT
15.9
10.9
17
11
D64.9
ICD-10 Finland
Anaemia, unspecified
2.5
10.7
72
312
7101A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic sclerosis[SCLERODERMA]
61.1
10.7
12
*
RT231, ,
NOMESCO Finland
61.1
10.7
12
*
M35.8
ICD-10 Finland
Other specified systemic involvement of connective tissue
61.1
10.7
12
*
I27.8
ICD-10 Finland
Other specified pulmonary heart diseases
61.1
10.7
12
*
C08DB01
ATC
diltiazem; oral
3.4
10.6
39
121
R13
ICD-10 Finland
Dysphagia
2.6
10.5
64
264
K22.1
ICD-10 Finland
Ulcer of oesophagus
7.9
10.5
23
30
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.5
10.4
67
284
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.2
10.3
28
70
S97
ICPC
Chronic ulcer skin
2.8
10.2
52
196
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
4.2
10.1
27
67
NDQ20
NOMESCO Finland
Amputation of finger
40.8
10.0
12
*
L99
ICPC
Musculoskeletal disease other
4.3
10.0
26
63
ZX120
NOMESCO Finland
Intravenous
2.4
9.9
73
329
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
3.6
9.9
33
96
H02AB07
ATC
prednisone; oral
2.1
9.8
100
516
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
20.4
9.8
14
7
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.3
9.8
77
358
GX1K5
NOMESCO Finland
Diffusion capacity
13.7
9.7
16
12
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.2
9.7
38
123
RT272, ,
NOMESCO Finland
15.4
9.6
15
10
NHQ40
NOMESCO Finland
Amputation of toe
8.9
9.4
19
22
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
9.7
9.3
18
19
A10BA02
ATC
metformin; oral
0.4
9.3
48
1087
A02BC05
ATC
esomeprazole; systemic
1.7
9.3
276
2000
SPAT1249
SPAT
Treatment-related counselling outside office
1.7
9.2
244
1712
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
8.9
142
857
C02DE02, ,
ATC
10.9
8.8
16
15
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
4.0
8.8
25
65
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
3.5
8.7
30
89
SPAT1263
SPAT
Sampling
1.7
8.6
253
1819
R50.9
ICD-10 Finland
Fever, unspecified
2.0
8.5
98
528
WZC30
NOMESCO Finland
Teaching
1.9
8.5
114
650
I78.8
ICD-10 Finland
Other diseases of capillaries
91.3
8.4
9
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.9
8.4
122
713
B01AC27
ATC
selexipag; oral
+∞
8.4
8
*
RJ512, ,
NOMESCO Finland
+∞
8.4
8
*
383
Kela drug reimbursment
Selexipag
+∞
8.4
8
*
XF614
NOMESCO Finland
Measurement of pulmonary artery pressure
+∞
8.4
8
*
C03CA01
ATC
furosemide; systemic
1.8
8.3
166
1069
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.5
8.3
52
217
E000001, ,
ATC
1.9
8.3
132
793
R22.3
ICD-10 Finland
Localized swelling, mass and lump, upper limb
3.9
8.3
24
63
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.1
8.2
85
440
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.8
8.2
132
797
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
2.0
8.2
93
499
A02BC01
ATC
omeprazole; systemic
1.7
8.2
176
1159
R76.0
ICD-10 Finland
Raised antibody titre
17.5
8.1
12
7
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.1
8.1
81
415
J01DB01
ATC
cefalexin; oral
2.0
8.0
497
4334
PD4AC
NOMESCO Finland
Arterigography of lower extremity with X-ray
7.4
8.0
18
25
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
8.6
7.9
16
19
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.8
7.8
40
151
XF622
NOMESCO Finland
Measurement of minute volume of heart
45.6
7.7
9
*
J01AA04
ATC
lymecycline; systemic
2.0
7.7
88
473
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
7.7
81
423
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.0
7.6
87
467
K76.9
ICD-10 Finland
Liver disease, unspecified
4.5
7.5
18
41
R4180
NOMESCO Finland
Podiatric therapy
6.6
7.5
18
28
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
3.1
7.5
31
104
NDQ48
NOMESCO Finland
Revision or amputation or exarticulation of finger
81.1
7.4
8
*
GD1UN
NOMESCO Finland
Lung circulation SPECT
13.6
7.4
12
9
GX1D5
NOMESCO Finland
Flow volume spirometry
16.0
7.2
11
7
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.8
7.2
140
890
Z3226
NOMESCO Finland
Physiotherapist
1.8
7.2
118
714
A02BC03
ATC
lansoprazole; oral
1.7
7.2
187
1289
K11.2
ICD-10 Finland
Sialoadenitis
3.1
7.1
29
96
UJF92
NOMESCO Finland
Capsular endoscopy
4.1
7.1
19
47
K11.71
ICD-10 Finland
Xerostomy (dry mouth)
6.2
7.1
18
30
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
3.2
6.9
27
87
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
3.6
6.9
22
62
SBA00
NOMESCO Finland
Microbiological examinations
3.3
6.9
26
82
PHD76
NOMESCO Finland
Resection of long saphenous vein
2.6
6.8
39
156
JGC01
NOMESCO Finland
Laparoscopic rectopexy
6.2
6.8
17
28
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.8
6.8
102
600
K23.8*B37.8
ICD-10 Finland
Esophagitis caused by candidiasis
16.9
6.8
10
6
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
6.8
188
1314
SPAT1255
SPAT
Intravenous administration of medicine
2.5
6.7
42
176
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.6
6.6
235
1743
NFQ20
NOMESCO Finland
Amputation of femur
10.2
6.6
12
12
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.7
6.5
34
130
B01AC04
ATC
clopidogrel; oral
1.9
6.5
84
471
J02AC01
ATC
fluconazole; systemic
1.6
6.5
283
2195
WZC00
NOMESCO Finland
Treatment plan or consultation
1.6
6.5
228
1684
PB1BC
NOMESCO Finland
Extensive angiography of upper extremity with X-ray
70.6
6.4
7
*
G73.7
ICD-10 Finland
Myopathy in other diseases classified elsewhere
70.6
6.4
7
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.6
6.4
36
143
A03FA02
ATC
cisapride; oral, rectal
2.2
6.4
52
245
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
2.8
6.4
32
120
SPAT1211
SPAT
Application of soft bandage
2.2
6.3
55
266
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.3
6.3
46
207
C02KX02
ATC
ambrisentan; oral
+∞
6.3
6
*
ADA20
NOMESCO Finland
Thoracal sympathectomy
27.0
6.2
8
*
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.8
6.2
95
561
M05BA04
ATC
alendronic acid; oral
2.0
6.2
66
345
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.2
6.1
52
249
RJ420, ,
NOMESCO Finland
12.7
6.1
10
8
A06AC51
ATC
ispaghula, combinations; oral
2.5
6.1
37
153
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
6.8
6.1
14
21
N03AX16
ATC
[U] pregabalin
1.6
6.0
151
1024
S18
ICPC
Laceration/cut
1.5
6.0
286
2247
J01MA02
ATC
ciprofloxacin; systemic
1.6
6.0
216
1596
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
308
193
32.59
307.65
1.7
1.3
2.98
2.06
u/ml
0.55
80
21
291
149
37.87
307.65
1.6
1.3
15.56
8.93
u/ml
0.30
39
11
305
194
31.76
307.65
1.7
1.3
5.47
5.87
u/ml
0.05
117
33
309
204
30.99
307.65
1.7
1.2
4.29
13.45
u/ml
0.40
19
13
248
159
26.34
307.04
1.7
1.2
24.71
55.87
u/ml
1.10
41
20
287
262
20.54
294.54
2.2
1.9
4.89
6.88
iu/ml
0.75
91
60
229
153
23.95
276.21
1.5
1.3
0.40
—
u/ml
—
9
0
195
171
16.61
199.44
2.0
1.8
0.20
0.24
g/l
3.90
185
164
195
180
15.75
193.02
2.0
1.7
1.08
1.22
g/l
5.49
186
171
376
859
10.45
183.98
1.8
1.4
2120.14
483.17
titre
37.58
279
202
211
253
12.48
174.45
1.7
1.3
7.53
0.98
u/ml
3.09
18
12
491
1587
14.03
171.41
5.5
3.0
682.50
944.16
ng/l
1.07
462
1332
135
96
17.98
153.50
1.4
1.1
14.69
2.60
u/ml
—
13
5
103
61
20.28
127.61
1.2
1.2
—
—
—
0
0
75
20
42.87
123.25
2.9
1.2
8.72
9.00
ug/l
0.13
75
20
70
32
24.71
96.36
1.2
1.2
—
—
—
0
0
551
2885
16.66
94.46
14.4
6.1
1.64
1.94
e9/l
8.55
539
2530
554
2929
17.82
93.67
14.6
6.4
0.19
0.18
e9/l
0.92
542
2553
79
51
17.75
93.13
1.3
1.1
—
—
—
0
0
85
65
15.13
91.47
1.3
1.2
14.13
70.43
u/ml
—
15
7
79
53
17.08
91.28
1.3
1.1
—
—
—
0
0
79
53
17.08
91.28
1.3
1.1
—
—
—
0
0
77
50
17.58
90.45
1.3
1.2
—
—
—
0
0
79
56
16.15
88.60
1.3
1.1
—
—
—
0
0
552
3153
14.31
78.42
16.7
9.6
3.71
4.00
e9/l
3.31
539
2753
176
435
5.36
69.72
3.8
3.0
9.65
10.25
g/l
0.91
166
404
159
363
5.64
68.89
4.0
2.8
98.78
150.42
ng/l
1.77
154
336
375
1707
4.33
65.34
2.8
2.1
102.42
202.34
u/l
1.90
364
1620
319
1366
3.94
59.05
3.2
2.5
311.29
320.90
umol/l
1.01
307
1196
48
28
18.59
58.95
1.0
1.1
—
—
—
0
0
502
2966
5.88
58.30
6.7
4.1
9.45
4.89
estimate
0.19
145
620
498
2941
5.66
57.39
6.6
4.0
0.00
0.00
estimate
0.50
143
605
499
3000
5.51
54.86
6.7
4.1
0.00
0.02
estimate
1.49
145
587
133
358
4.51
45.98
1.8
1.7
1.62
1.31
g/l
1.16
122
329
325
1637
3.22
42.38
6.9
4.2
0.00
0.00
estimate
0.80
143
583
433
2715
3.29
36.19
3.5
2.5
81.18
79.18
nmol/l
0.84
414
2450
257
1262
2.85
32.93
1.3
1.3
41.86
31.24
iu/ml
0.51
118
406
394
2466
2.83
30.64
20.0
10.8
0.00
0.00
e9/l
0.22
368
2011
423
2809
2.83
28.19
8.6
6.8
1.21
1.22
mmol/l
1.77
372
2427
393
2546
2.66
26.98
7.8
5.9
1.22
1.22
mmol/l
0.51
378
2354
61
133
5.00
26.80
1.7
1.8
118.89
127.87
g/l
1.08
19
102
229
1209
2.47
23.60
1.6
1.5
2.09
2.30
g/l
1.04
154
716
346
2209
2.39
22.97
6.7
3.9
0.05
0.04
estimate
0.11
130
495
42
79
5.65
21.68
1.5
1.1
3.47
1.38
u/ml
0.61
19
24
123
511
2.78
20.42
3.0
2.2
0.20
0.21
g/l
1.81
115
484
362
2435
2.28
20.18
6.7
4.5
35.87
36.04
g/l
0.25
349
2295
178
891
2.43
20.09
3.9
2.3
10.71
13.01
umol/l
4.68
172
835
41
82
5.30
19.79
1.4
1.1
7.10
6.74
u/ml
0.03
20
31
62
174
3.87
19.60
1.7
1.5
0.11
0.16
iu/ml
—
9
21
156
757
2.45
18.69
3.8
2.4
19.08
22.28
%
2.26
148
715
208
1153
2.25
18.23
1.3
1.3
15.83
11.87
u/ml
0.28
84
426
23
7
34.11
18.08
1.0
1.1
—
—
—
0
0
237
1402
2.16
17.51
4.3
2.2
2.99
2.97
mg/l
0.03
221
1193
163
830
2.34
17.36
3.8
2.3
2.35
2.36
g/l
0.11
158
772
25
14
18.60
16.60
1.0
1.1
—
—
—
0
0
257
1595
2.09
16.50
5.1
3.4
0.00
0.01
estimate
0.96
129
489
105
449
2.63
16.24
2.4
2.8
64.51
67.26
g/l
2.57
100
417
204
1173
2.13
15.91
3.6
2.6
3.58
6.96
e6/l
3.57
195
1077
41
99
4.38
15.82
1.4
1.3
—
—
—
0
0
241
1481
2.07
15.70
3.8
3.0
0.20
0.39
e6/l
1.54
199
1050
168
903
2.21
15.49
3.1
2.8
0.70
1.17
e6/l
2.09
121
446
268
1731
2.01
15.04
4.0
3.2
22.47
41.73
e6/l
0.80
229
1303
25
44
5.89
13.78
1.2
1.2
—
—
—
0
0
47
140
3.56
13.58
1.6
1.6
—
—
—
0
0
24
21
11.86
13.41
1.2
1.0
—
—
—
0
0
33
78
4.42
13.07
1.7
1.6
—
—
—
0
0
22
36
6.31
13.01
1.5
1.4
44.62
45.89
%
0.04
12
19
53
177
3.19
12.80
1.5
1.3
308.85
307.52
ug/g
0.01
30
101
153
850
2.08
12.64
2.5
1.9
—
—
—
0
0
38
105
3.80
12.24
1.7
1.5
—
—
—
0
0
386
2948
1.91
12.07
8.2
6.2
10.05
10.32
umol/l
0.20
368
2821
221
1418
1.90
11.95
1.4
1.3
0.51
1.56
u/ml
2.07
56
386
46
147
3.31
11.93
1.7
1.6
—
—
—
0
0
328
2386
1.85
11.88
13.4
11.8
1.16
1.17
inr
0.15
278
1951
25
51
5.08
11.78
1.6
1.5
—
—
—
0
0
34
91
3.91
11.45
1.6
1.6
—
—
—
0
0
574
5214
6.37
11.05
30.9
15.0
18.55
22.19
mg/l
2.10
518
4256
37
108
3.59
11.02
6.9
5.2
2160.54
156.50
iu/ml
0.89
13
14
38
113
3.53
11.01
1.4
1.3
—
—
—
0
0
86
399
2.35
10.99
2.1
1.5
—
—
—
0
0
40
124
3.39
10.88
1.8
1.5
—
—
—
0
0
46
156
3.12
10.83
2.8
2.5
—
—
—
0
0
286
2036
1.79
10.74
4.9
3.6
20.82
77.78
ng/l
1.04
206
1391
124
680
2.05
10.42
5.7
4.8
1.02
1.04
mmol/l
0.29
115
622
26
62
4.34
10.19
1.4
1.6
53.56
52.50
%
0.04
16
38
35
104
3.52
10.16
1.8
1.5
—
—
—
0
0
118
641
2.05
10.15
2.2
1.8
—
—
—
0
0
131
758
1.94
9.37
1.8
2.1
150.51
108.42
ug/g
1.22
106
605
20
42
4.90
9.12
1.2
1.6
—
—
—
0
0
20
42
4.90
9.12
1.2
1.6
—
—
—
0
0
20
42
4.90
9.12
1.2
1.6
—
—
—
0
0
281
2057
1.70
9.05
3.0
3.5
2.35
2.37
mmol/l
1.77
261
1870
52
210
2.62
8.90
2.1
2.0
1.47
1.58
g/l
0.38
45
184
87
447
2.11
8.61
2.3
2.2
0.15
0.41
e6/l
1.41
81
420
40
143
2.93
8.61
1.6
1.4
—
—
—
0
0
109
610
1.97
8.54
2.3
1.9
—
—
—
0
0
89
463
2.09
8.53
4.3
3.7
1.22
1.23
mmol/l
0.93
82
405
103
569
1.98
8.36
9.9
8.0
0.59
1.23
mmol/l
0.96
90
478
433
3609
1.77
8.27
6.0
4.9
19.50
2295.48
e6/l
—
6
52
100
551
1.98
8.17
1.6
2.2
358.03
381.67
nmol/l
0.36
95
519
342
2701
1.64
7.75
4.7
3.0
88.99
99.47
ug/l
0.43
324
2523
20
34
6.05
7.74
1.8
1.8
—
—
—
0
0
241
1745
1.65
7.74
3.3
2.4
60.63
63.83
u/l
0.29
220
1613
187
1293
1.66
7.06
8.1
4.2
1.02
1.02
kg/l
0.11
158
866
20
52
3.95
7.03
1.2
1.2
—
—
—
0
0
375
3089
1.60
6.66
6.8
4.7
6.33
6.60
mmol/l
1.61
368
2927
38
153
2.59
6.57
1.1
1.2
—
—
—
0
0
136
881
1.71
6.51
1.7
1.7
1219.66
1221.01
nmol/l
0.01
108
640
18
46
4.01
6.48
1.3
1.7
—
—
—
0
0
138
900
1.70
6.44
3.8
3.1
0.82
0.82
mmol/l
0.28
128
848
25
81
3.18
6.39
1.4
1.4
150.00
170.06
au/ml
—
5
24
246
1857
1.56
6.29
4.8
3.0
31.28
28.64
u/l
1.13
236
1746
23
75
3.15
5.83
1.1
1.1
—
—
—
0
0
16
31
5.28
5.74
1.4
1.2
—
—
—
0
0
41
183
2.33
5.72
1.2
1.3
—
—
—
0
0
109
687
1.72
5.71
9.7
6.1
103.94
103.96
mmol/l
0.02
109
687
38
164
2.41
5.71
1.4
1.2
—
—
—
0
0
386
3257
1.54
5.70
3.1
3.0
—
—
—
0
0
21
68
3.17
5.39
3.2
1.8
10.43
60.84
u/ml
0.44
21
68
18
53
3.47
5.34
1.3
1.6
—
—
—
0
0
217
1639
1.52
5.32
1.8
1.7
21.70
21.36
nmol/l
0.12
191
1375
30
120
2.58
5.29
1.2
1.8
—
—
—
0
0
15
30
5.10
5.28
1.6
1.6
410.80
522.09
e6/l
—
10
23
23
80
2.95
5.25
1.6
1.4
—
—
—
0
0
161
1150
1.55
5.06
1.6
1.7
487.11
25676126.68
pmol/l
1.32
137
962
59
320
1.94
5.02
5.6
3.2
5.21
5.15
kpa
0.23
59
311
70
406
1.82
4.86
1.3
1.3
64.01
189.91
u/ml
2.13
65
379
11
17
6.57
4.79
1.0
1.8
—
—
—
0
0
11
17
6.57
4.79
1.0
1.8
—
—
—
0
0
11
17
6.57
4.79
1.0
1.8
—
—
—
0
0
163
1183
1.52
4.73
2.4
2.7
2.45
2.46
mmol/l
0.32
150
1069
10
14
7.25
4.67
1.6
1.1
—
—
—
0
0
13
26
5.09
4.65
1.0
1.7
—
—
—
0
0
13
26
5.09
4.65
1.0
1.7
—
—
—
0
0
13
26
5.09
4.65
1.0
1.7
—
—
—
0
0
13
26
5.09
4.65
1.0
1.7
—
—
—
0
0
173
1276
1.51
4.64
2.0
1.6
1.39
1.11
mg/l
0.28
147
1016
113
758
1.61
4.62
2.4
1.8
29.76
29.14
s
0.72
113
734
34
155
2.27
4.56
2.8
3.3
10.04
2.14
ratio
0.74
19
88
28
117
2.46
4.54
1.6
1.6
—
—
—
0
0
17
54
3.21
4.52
1.8
3.0
60.32
54.95
%
0.40
17
49
95
615
1.65
4.47
2.9
2.4
5.90
6.14
umol/l
0.06
88
535
20
72
2.84
4.32
2.1
1.5
—
—
—
0
0
483
4384
1.58
4.28
34.8
19.0
14.28
13.62
%
18.44
483
4334
75
462
1.72
4.25
2.9
2.7
70.12
67.63
ml/min/173m2
0.21
34
200
300
2489
1.42
4.24
2.3
2.1
97.14
98.92
pmol/l
0.25
157
1199
547
5139
1.99
4.20
25.2
14.8
80.20
80.81
ml/min/173m2
0.31
531
4774
141
1020
1.50
4.09
4.7
3.7
109.14
235.08
ng/l
0.96
109
753
11
22
5.07
4.02
1.1
1.5
—
—
—
0
0
18
64
2.87
3.99
1.1
1.1
—
—
—
0
0
32
151
2.18
3.98
1.6
1.6
4862.42
14737.26
e6/l
1.26
26
100
15
48
3.18
3.95
1.5
1.5
386914.00
204141.46
e6/l
—
10
28
8
11
7.36
3.87
1.0
1.1
108.38
105.27
%
—
8
11
9
15
6.07
3.83
2.3
1.7
1.70
1.67
ratio
—
9
15
14
44
3.24
3.80
2.4
1.5
—
—
—
0
0
182
1405
1.43
3.74
6.6
3.6
92.44
94.65
%
0.63
175
1371
48
269
1.85
3.74
4.6
3.1
2.08
1.92
mmol/l
0.11
33
206
18
67
2.74
3.69
2.1
1.6
—
—
—
0
0
7
9
7.85
3.56
1.4
1.3
—
—
—
0
0
66
413
1.67
3.54
2.5
2.5
21.08
23.54
au/ml
0.12
11
34
30
145
2.13
3.54
1.5
1.4
—
—
—
0
0
12
31
3.93
3.50
2.3
1.4
—
—
—
0
0
12
32
3.81
3.40
2.3
1.4
—
—
—
0
0
7
10
7.07
3.37
4.6
7.8
5.00
5.78
kpa
—
7
10
7
10
7.07
3.37
4.0
7.7
5.16
5.02
kpa
—
7
10
71
459
1.62
3.37
10.8
6.6
1.15
1.21
mmol/l
0.28
71
451
12
34
3.58
3.21
2.4
1.4
—
—
—
0
0
45
262
1.78
3.13
1.4
2.4
42.62
40.73
u/l
0.26
45
234
61
389
1.63
3.06
2.4
2.3
21.41
5.40
ug/l
0.59
50
345
481
4449
1.46
3.03
5.3
4.9
15.31
14.78
pmol/l
4.97
450
4116
34
184
1.90
2.98
2.4
1.8
—
—
—
0
0
45
269
1.73
2.88
1.5
1.4
—
—
—
0
0
39
224
1.79
2.86
1.8
1.7
—
—
—
0
0
71
479
1.55
2.83
3.8
3.3
70.85
76.88
ng/l
0.36
64
420
7
14
5.05
2.73
1.3
1.0
—
—
—
0
0
6
10
6.05
2.70
1.3
1.3
—
—
—
0
0
79
553
1.50
2.66
4.1
3.3
—
—
—
0
0
12
43
2.83
2.66
1.5
1.4
4401.20
60178.35
e6/l
—
5
20
71
487
1.52
2.64
4.1
3.1
1.25
2.03
mmol/l
1.13
64
421
534
5078
1.59
2.61
6.6
6.0
2.09
1.88
mu/l
2.49
503
4723
11
36
3.09
2.57
1.8
2.7
804.91
748.19
mg
0.05
11
36
24
122
2.01
2.54
3.4
2.6
10.89
7.79
pmol/l
0.47
24
122
48
305
1.63
2.48
2.0
1.7
—
—
—
0
0
31
174
1.83
2.47
2.1
1.7
—
—
—
0
0
18
83
2.21
2.43
1.4
1.3
255.00
233.61
u/ml
0.10
11
46
11
39
2.85
2.35
1.9
2.4
—
—
—
0
0
108
824
1.38
2.30
3.4
2.9
3.93
3.66
e6/l
0.07
60
367
16
72
2.26
2.29
1.4
1.3
—
—
—
0
0
16
73
2.23
2.23
1.4
1.3
—
—
—
0
0
16
76
2.14
2.04
1.4
1.3
—
—
—
0
0
16
76
2.14
2.04
1.4
1.3
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
23
126
1.86
2.01
2.7
2.4
0.35
0.41
iu/ml
—
9
70
9
32
2.84
2.00
1.3
4.2
664.44
747.16
u/ml
—
9
32
28
164
1.74
1.98
1.4
2.7
12.11
12.11
mg/l
0.00
28
155
7
21
3.36
1.97
1.3
1.8
—
—
—
0
0
7
21
3.36
1.97
1.3
1.8
—
—
—
0
0
554
5358
1.64
1.96
26.2
17.5
139.41
139.74
mmol/l
1.97
549
5248
12
52
2.34
1.89
1.3
1.1
89.92
111.33
pmol/l
0.91
12
52
161
1339
1.28
1.88
3.8
2.3
—
—
—
0
0
15
72
2.11
1.88
1.4
1.3
—
—
—
0
0
35
224
1.60
1.81
2.1
2.8
25.57
1058.85
u/ml
0.98
30
192
24
139
1.76
1.78
2.5
3.2
0.86
2.03
index
—
7
69
27
429
0.61
1.74
1.7
1.8
3.43
3.48
mmol/l
0.09
19
323
285
2555
1.23
1.67
3.8
2.7
—
—
estimate
—
0
0
15
76
2.00
1.65
1.4
1.3
—
—
—
0
0
5
14
3.59
1.62
4.4
1.9
3.20
4.56
ug/l
—
5
14
6
20
3.02
1.58
1.2
1.1
—
—
—
0
0
552
5365
1.51
1.52
26.5
17.6
3.95
3.94
mmol/l
0.09
546
5245
6
21
2.88
1.51
4.2
5.6
—
—
—
0
0
18
101
1.81
1.50
1.4
1.3
—
—
—
0
0
18
101
1.81
1.50
1.4
1.3
—
—
—
0
0
41
567
0.70
1.39
1.8
2.1
2.97
3.31
ratio
1.31
31
462
80
633
1.31
1.37
9.2
6.3
—
—
—
0
0
10
47
2.15
1.34
1.1
1.2
—
—
—
0
0
10
47
2.15
1.34
1.1
1.2
—
—
—
0
0
6
24
2.52
1.30
1.0
1.0
—
—
—
0
0
5
18
2.79
1.28
3.2
3.1
0.60
0.62
mmol/l
—
5
18
34
479
0.69
1.28
1.9
1.9
—
—
—
0
0
57
436
1.34
1.25
1.5
1.5
—
—
—
0
0
140
1220
1.19
1.04
1.4
1.4
—
—
—
0
0
5
22
2.28
1.03
1.0
1.4
—
—
—
0
0
7
34
2.07
1.03
1.1
1.1
—
—
—
0
0
33
437
0.74
0.91
1.8
1.8
—
—
—
0
0
170
1887
0.86
0.90
3.1
3.2
6.12
6.87
mmol/l
1.55
140
1583
166
1843
0.86
0.88
3.8
4.0
19.58
7.63
mg/mmol
0.66
90
1030
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
32
1.88
0.82
1.0
1.1
—
—
—
0
0
0
24
0.00
0.79
0.0
1.1
—
—
—
0
0
379
3617
1.14
0.76
4.6
3.2
56.91
42.99
u/l
2.60
355
3405
5
24
2.09
0.74
1.4
2.0
34.94
41.68
g/l
—
5
24
5
28
1.79
0.66
3.4
2.0
97.80
110.82
%
—
5
28
64
544
1.20
0.65
2.9
2.2
30.98
40.71
u/l
1.30
59
448
18
129
1.41
0.64
1.2
1.2
2.23
11.82
e6/l
0.68
13
93
514
5030
1.18
0.63
4.1
4.3
1.14
1.26
mmol/l
6.03
480
4611
5
30
1.67
0.61
4.8
3.1
0.70
1.38
%
—
5
30
0
20
0.00
0.60
0.0
1.1
—
114.64
—
0
11
18
131
1.39
0.59
1.3
1.2
68.46
168.70
e6/l
0.55
13
99
10
64
1.57
0.59
4.8
3.6
—
—
—
0
0
6
35
1.72
0.58
1.7
1.8
—
—
—
0
0
6
35
1.72
0.58
1.0
1.1
—
—
—
0
0
14
98
1.44
0.57
1.1
1.1
0.51
1.51
u/ml
—
9
55
494
5041
0.87
0.56
5.4
6.3
37.72
38.97
mmol/mol
1.08
465
4726
537
5286
1.19
0.54
5.0
5.3
4.65
4.81
mmol/l
3.46
509
4916
13
181
0.71
0.53
1.1
1.2
1.53
1.62
g/l
0.59
13
181
20
152
1.33
0.52
1.2
2.0
3984.30
4406.74
u/l
—
5
62
535
5267
1.18
0.52
4.9
5.1
1.63
1.57
mmol/l
2.24
504
4874
79
700
1.15
0.51
4.2
4.9
33.79
33.07
%
0.24
58
440
32
262
1.23
0.49
1.8
1.4
—
—
—
0
0
14
188
0.74
0.47
1.1
1.2
0.90
0.92
g/l
0.12
14
188
11
77
1.44
0.46
1.3
1.2
0.22
0.18
nmol/l
0.73
11
52
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
8
60
1.34
0.40
1.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
41.42
—
0
18
542
5356
1.16
0.39
5.4
6.0
2.60
2.79
mmol/l
6.18
513
4966
0
19
0.00
0.39
0.0
1.0
—
100.50
—
0
10
19
151
1.27
0.39
1.7
2.2
14.88
11.35
nmol/l
0.52
13
143
19
152
1.26
0.37
1.2
1.2
646.11
504.81
mg/l
0.60
19
143
28
331
0.84
0.36
1.7
1.3
39.52
31.19
iu/l
0.50
22
290
21
171
1.24
0.36
1.5
1.1
—
—
—
0
0
26
306
0.84
0.33
1.0
1.1
—
—
—
0
0
28
239
1.18
0.32
1.5
1.5
—
—
—
0
0
7
55
1.28
0.30
1.0
1.0
—
—
—
0
0
24
205
1.18
0.28
1.7
1.4
0.28
0.34
mg/l
—
8
71
8
64
1.25
0.27
1.0
1.1
—
—
—
0
0
14
113
1.24
0.27
6.0
1.7
0.90
0.85
nmol/l
0.14
14
93
5
73
0.68
0.26
1.0
1.5
—
—
—
0
0
32
285
1.13
0.23
1.7
1.4
—
—
—
0
0
237
2442
0.95
0.23
1.8
2.0
1.25
1.35
mmol/l
1.54
193
2058
20
172
1.17
0.22
1.5
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
0.01
—
0
5
0
10
0.00
0.21
0.0
1.0
—
114.10
—
0
10
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
0.06
—
0
5
42
383
1.10
0.21
4.4
4.3
18.50
22.81
%
1.22
24
183
5
43
1.16
0.21
1.0
1.7
48.00
99.25
ng/l
—
5
43
0
13
0.00
0.21
0.0
2.5
—
2.54
—
0
5
6
48
1.25
0.20
2.0
1.3
—
—
—
0
0
24
271
0.88
0.20
2.3
1.9
—
—
—
0
0
19
218
0.87
0.20
1.8
1.8
—
—
—
0
0
52
555
0.93
0.16
1.4
1.6
1.55
1.39
%
0.69
44
489
106
1017
1.05
0.16
1.7
1.5
—
—
—
0
0
32
294
1.09
0.15
2.8
2.9
0.51
0.78
ug/l
2.01
22
188
15
168
0.89
0.12
1.6
1.9
1.62
4.02
iu/l
—
5
66
17
155
1.10
0.09
1.6
1.3
—
—
—
0
0
12
107
1.12
0.08
2.8
3.7
28.00
22.49
mg/l
—
5
69
41
391
1.05
0.08
2.2
3.3
4.10
4.44
pmol/l
1.54
33
344
6
74
0.81
0.07
1.5
1.5
—
—
—
0
0
8
94
0.85
0.06
1.0
1.2
126.72
18.68
u/l
—
8
79
19
202
0.94
0.05
1.3
2.0
9.35
2.49
mg/l
0.43
19
150
19
179
1.06
0.05
1.3
1.3
274.43
259.24
miu/ml
—
7
85
517
5157
1.02
0.03
4.6
5.2
5.52
5.87
mmol/l
13.52
481
4751
17
161
1.06
0.03
1.5
1.7
330.83
302.40
mu/l
0.11
12
147
45
461
0.97
0.03
1.1
1.2
106.31
154.68
u/ml
0.35
13
198
17
175
0.97
0.00
1.6
1.2
—
—
—
0
0
60
605
0.99
0.00
2.4
4.1
4.62
8.95
ug/l
1.91
49
487
49
487
1.01
0.00
6.2
5.1
2.74
2.63
ug/l
0.03
44
431
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
88
0.91
-0.00
1.1
1.1
—
1.88
—
0
15
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
-0.00
1.0
1.4
1.58
3.02
ug/l
—
5
40
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
6.14
—
0
8
0
8
0.00
-0.00
0.0
1.3
—
1.21
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.01
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
65.67
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint CREST and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CREST | 2.418 [2.09, 2.8] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.062 |
During the follow-up period (1.1.1998 — 31.12.2019), 370 out of 1714 females with CREST died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CREST | 2.657 [1.86, 3.8] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 263 males with CREST died.
Mortality risk
Mortality risk for people of age
years, who have CREST.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.263% | 0.492% |
| 5 | 1.279% | 3.229% |
| 10 | 3.077% | 7.7% |
| 15 | 6.036% | 14.045% |
| 20 | 10.835% | 23.099% |
Relationships between endpoints
↥Index endpoint: CREST – CR(E)ST syndrome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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