Autonomic disorders

G6_AUTONOM

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G90
  • Cause of death: ICD-10 G90

2 out of 7 registries used, show all original rules.

1038

4. Check minimum number of events

None

1038

5. Include endpoints

1063

6. Filter based on genotype QC (FinnGen only)

963

Control definitions (FinnGen only)

Control exclude
G6_OTHNEU

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G90-G99
Name in latin
Morbositates systematis nervosi autonomici

Similar endpoints

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6006 2906 3053
Only index persons 5139 2553 2586
Unadjusted period prevalence (%)
Whole population 0.08 0.08 0.09
Only index persons 0.10 0.09 0.10
Median age at first event (years)
Whole population 56.80 57.86 55.60
Only index persons 55.36 56.45 54.29

-FinnGen-

Key figures

All Female Male
Number of individuals 963 547 416
Unadjusted period prevalence (%) 0.19 0.19 0.19
Median age at first event (years) 55.64 54.09 57.69

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
995
Matched controls
9950
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G90.2
ICD-10 Finland
Horner syndrome
7958.4
307.7
461
*
G90.0
ICD-10 Finland
Idiopathic peripheral autonomic neuropathy
+∞
147.7
138
*
M89.0
ICD-10 Finland
Algoneurodystrophy
32.5
119.6
78
26
G90.3
ICD-10 Finland
Multi-system degeneration
+∞
111.6
105
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
22.7
94.5
70
33
G90.8
ICD-10 Finland
Other disorders of autonomic nervous system
+∞
87.8
83
*
AA1AD
NOMESCO Finland
CT of head and brain
3.5
76.9
402
1620
G56.4
ICD-10 Finland
Causalgia
37.9
75.5
47
13
H02.4
ICD-10 Finland
Ptosis of eyelid
9.0
72.1
93
113
G90.9
ICD-10 Finland
Disorder of autonomic nervous system, unspecified
750.3
72.1
70
*
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
10.0
70.2
83
90
H57.0
ICD-10 Finland
Anomalies of pupillary function
23.4
64.5
47
21
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
7.8
63.2
91
126
N03AX16
ATC
[U] pregabalin
3.2
61.4
340
1388
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
21.4
56.9
43
21
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.3
52.1
148
385
G20
ICD-10 Finland
Parkinson disease
7.9
51.5
73
99
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
8.1
49.8
69
91
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.2
49.4
148
400
N06AX21
ATC
duloxetine; oral
3.5
47.7
196
657
G90.5
ICD-10 Finland
Complex regional pain syndrome type I
490.3
47.7
47
*
N87
ICPC
Parkinsonism
12.0
44.1
45
39
R55
ICD-10 Finland
Syncope and collapse
3.5
42.3
170
560
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.6
42.1
155
482
N03AX12
ATC
[U] gabapentin; oral
2.9
41.0
230
921
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
4.8
40.8
99
226
H02AA02
ATC
fludrocortisone; oral
13.7
39.3
37
28
G90.6
ICD-10 Finland
Complex regional pain syndrome type II
+∞
38.8
37
*
G90.7
ICD-10 Finland
Complex regional pain syndrome, other and unspecified type
+∞
38.8
37
*
U09.9
ICD-10 Finland
Post COVID-19 condition, unspecified
12.3
38.7
39
33
G44.0
ICD-10 Finland
Cluster headache syndrome
10.7
38.0
42
41
R51.80
ICD-10 Finland
Headache
2.8
36.6
226
948
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
34.6
537
3396
N03AX09
ATC
lamotrigine; oral
4.4
34.5
91
222
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
9.3
33.5
41
46
TAB00
NOMESCO Finland
Lumbar puncture
4.7
33.0
79
178
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
7.9
32.9
46
61
PA6AD
NOMESCO Finland
CT of neck arteries
5.5
30.9
61
116
N06AX16
ATC
venlafaxine; oral
2.7
30.5
196
833
N28
ICPC
Limited function/disability (N)
7.8
29.9
42
56
N02BF02
ATC
pregabalin; oral
3.6
29.5
106
322
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.7
29.1
175
718
R42
ICD-10 Finland
Dizziness and giddiness
2.3
29.0
271
1368
N02AX02
ATC
tramadol; systemic, rectal
2.1
27.2
470
3007
R52.2
ICD-10 Finland
Other chronic pain
4.4
27.0
70
168
R53
ICD-10 Finland
Malaise and fatigue
2.2
26.8
305
1663
XCK00
NOMESCO Finland
Perimetry
3.7
26.5
88
253
M03BX01
ATC
baclofen; systemic
6.7
26.2
42
65
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
+∞
26.2
25
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
5.1
25.3
54
110
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.6
25.3
90
271
I67.0
ICD-10 Finland
Dissection of cerebral arteries, nonruptured
59.7
25.1
29
5
A28
ICPC
Limited function/disability NOS
2.4
24.3
206
989
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
24.1
321
1847
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
+∞
24.1
23
*
N03AE01
ATC
clonazepam; systemic
3.5
23.6
84
253
N04BD01
ATC
selegiline; oral
8.2
23.1
31
39
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
235.2
22.7
23
*
N04BC05
ATC
pramipexole; oral
3.0
22.2
107
387
N02BF01
ATC
gabapentin; oral
2.6
22.0
137
568
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.0
20.9
96
338
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
20.8
390
2505
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
5.4
20.5
41
79
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
20.2
254
1417
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.7
20.2
121
491
L28
ICPC
Limited function/disability (L)
2.2
20.1
207
1070
M79.6
ICD-10 Finland
Pain in limb
1.9
19.9
472
3254
N99
ICPC
Neurological disease other
7.9
19.6
27
35
I95.1
ICD-10 Finland
Orthostatic hypotension
4.0
19.6
57
149
J01MA02
ATC
ciprofloxacin; systemic
1.9
19.4
395
2590
ABD32
NOMESCO Finland
Implantation of temporary spinal stimulation device
20.5
19.1
28
14
A02BC05
ATC
esomeprazole; systemic
1.8
19.0
418
2803
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
4.4
18.9
48
113
R4110
NOMESCO Finland
Physiotherapy
1.9
18.9
299
1803
H02AB06
ATC
prednisolone; systemic
1.8
18.9
487
3427
R03DC03
ATC
montelukast; oral
2.2
18.8
192
987
G90.1
ICD-10 Finland
Familial dysautonomia [Riley-Day]
+∞
18.8
18
*
G91.0
ICD-10 Finland
Communicating hydrocephalus
+∞
18.8
18
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.3
18.8
153
716
XA800
NOMESCO Finland
Neuropsychological investigation
3.7
18.7
61
173
N06AX11
ATC
mirtazapine; oral
1.9
18.6
366
2367
PA6CG
NOMESCO Finland
Extensive MRI examination of neck vasculature with high intensity magnet
39.2
18.6
23
6
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
5.5
18.4
36
68
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.5
18.1
129
568
X59
ICD-10 Finland
Exposure to unspecified factor
2.1
18.1
215
1171
R4120
NOMESCO Finland
Occupational therapy
2.9
18.0
87
315
N05AH04
ATC
quetiapine; oral
2.1
17.8
206
1110
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
5.6
17.7
34
63
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.1
17.5
184
956
Z3226
NOMESCO Finland
Physiotherapist
2.1
17.2
199
1070
R4130
NOMESCO Finland
Speech therapy
4.4
17.0
43
101
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.3
16.9
147
706
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
2.9
16.8
80
287
G90.4
ICD-10 Finland
Autonomic dysreflexia
+∞
16.7
16
*
N29
ICPC
Neurological sympt/complt other
5.2
16.6
34
67
R06.0
ICD-10 Finland
Dyspnoea
1.9
16.5
291
1805
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.1
16.5
171
882
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
16.4
161
812
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.8
16.3
325
2092
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
16.3
256
1529
F43.1
ICD-10 Finland
Post-traumatic stress disorder
3.9
16.3
48
127
C07AB07
ATC
bisoprolol; oral
1.7
16.0
465
3335
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
3.3
16.0
63
202
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
16.0
207
1158
A01
ICPC
Pain general/multiple sites
2.4
15.9
121
548
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
15.8
152
761
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
15.7
266
1625
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
162.5
15.5
16
*
N05BA04
ATC
oxazepam; oral
1.8
15.4
277
1724
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.3
15.4
129
610
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
2.1
15.3
152
770
A03FA01
ATC
metoclopramide; systemic, rectal
1.9
15.2
236
1401
SPAT1229
SPAT
Assessment of need for aid
2.7
15.0
82
317
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
2.3
14.9
122
570
UJF32
NOMESCO Finland
Coloscopy
1.8
14.8
260
1602
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
57.6
14.8
17
*
N03AX11
ATC
topiramate; oral
4.1
14.7
41
104
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.6
14.7
50
146
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
14.7
282
1786
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.7
14.7
445
3206
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.4
14.7
103
450
G91.1
ICD-10 Finland
Obstructive hydrocephalus
+∞
14.6
14
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.8
14.6
74
275
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
3.8
14.6
45
123
WX002
NOMESCO Finland
Sedation and analgesia
2.0
14.6
198
1123
R13
ICD-10 Finland
Dysphagia
2.7
14.5
84
334
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
3.7
14.5
46
128
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
5.1
14.4
30
60
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.4
14.4
103
454
G93.3
ICD-10 Finland
Postviral fatigue syndrome
17.3
14.3
22
13
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.6
14.3
89
367
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
14.3
227
1355
ZXD05
NOMESCO Finland
Urgent procedure
1.8
14.3
311
2042
R52.9
ICD-10 Finland
Pain, unspecified
2.2
14.2
125
602
H04.10
ICD-10 Finland
Dry eye syndrome
2.2
14.1
133
658
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
14.0
348
2368
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.3
13.9
115
540
A02BC02
ATC
pantoprazole; systemic
1.7
13.8
667
5402
NA1AD
NOMESCO Finland
Cervical spine CT examination
3.0
13.8
63
221
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
4.9
13.6
30
63
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.5
13.4
90
385
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.3
13.3
108
503
M03BX02
ATC
tizanidine; oral
1.7
13.2
609
4844
C07AA05
ATC
propranolol; systemic
1.9
13.2
211
1259
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.4
13.0
47
143
C08DA01
ATC
verapamil; systemic
3.0
13.0
58
201
H57.1
ICD-10 Finland
Ocular pain
3.1
12.9
54
180
R5110, ,
SPAT
2.3
12.9
99
450
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.7
12.7
68
260
G43.3
ICD-10 Finland
Complicated migraine
4.6
12.7
30
67
K59.09
ICD-10 Finland
Constipation, unspecified
2.5
12.6
79
327
CBJ41
NOMESCO Finland
Shortening of superior tarsal muscle (Müller's muscle)
32.5
12.6
16
5
CBJ40
NOMESCO Finland
Resection of levator muscle of eyelid
11.2
12.6
23
21
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
12.6
187
1089
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.2
12.5
107
509
M35.7
ICD-10 Finland
Hypermobility syndrome
5.1
12.5
26
52
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
4.2
12.4
33
81
H02AB07
ATC
prednisone; oral
2.0
12.4
141
749
H53.1
ICD-10 Finland
Subjective visual disturbances
2.5
12.3
77
318
R33
ICD-10 Finland
Retention of urine
2.4
12.2
87
382
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
3.6
12.2
41
119
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.7
12.1
273
1795
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
12.0
257
1665
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.2
12.0
103
491
WX110
NOMESCO Finland
Infiltration anesthesia
1.7
12.0
704
5882
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.7
11.9
67
263
B01AA03
ATC
warfarin; systemic
1.9
11.8
167
956
N06AB04
ATC
citalopram; systemic
1.8
11.6
202
1232
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.8
11.5
58
215
N06AB10
ATC
escitalopram; oral
1.8
11.5
212
1316
G23.2
ICD-10 Finland
Multiple system atrophy, parkinsonian type [MSA-P]
121.4
11.4
12
*
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
121.4
11.4
12
*
JAH01
NOMESCO Finland
Laparoscopy
2.9
11.4
54
193
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.4
11.4
78
336
R50.9
ICD-10 Finland
Fever, unspecified
1.9
11.4
161
921
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.8
11.3
191
1154
ZXE00
NOMESCO Finland
One hour or less
1.6
11.3
373
2698
N02AA05
ATC
oxycodone; systemic
1.8
11.3
177
1045
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
2.1
11.3
115
586
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.0
11.2
50
173
T78.4
ICD-10 Finland
Allergy, unspecified
2.8
11.2
55
201
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.8
11.2
184
1103
R20.2
ICD-10 Finland
Paraesthesia of skin
2.4
11.1
81
359
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
11.1
419
3124
XKD06
NOMESCO Finland
Physiologic investigation of micturition
3.6
11.1
36
102
J01FF01
ATC
clindamycin; systemic
1.7
11.1
260
1723
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.1
11.1
47
158
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.2
11.1
99
479
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.0
11.1
129
690
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.1
11.1
116
597
R25.1
ICD-10 Finland
Tremor, unspecified
3.5
11.1
38
112
AEA00
NOMESCO Finland
Replacement of impulse generator of stimulation device in the nervous system
10.2
11.0
21
21
WX402
NOMESCO Finland
General anaesthesia
1.7
11.0
223
1420
Z3231
NOMESCO Finland
Registered nurse
1.7
10.9
263
1754
R01AD08
ATC
fluticasone; nasal
1.7
10.9
274
1849
G44.2
ICD-10 Finland
Tension-type headache
1.9
10.9
147
827
XF606
NOMESCO Finland
Ortostatic test
12.1
10.9
19
16
PA6BG
NOMESCO Finland
MRI examination of neck vasculature with high intensity magnet
12.1
10.9
19
16
M79.1
ICD-10 Finland
Myalgia
1.9
10.8
163
950
N04BC04
ATC
ropinirole; oral
9.0
10.8
22
25
N04BD02
ATC
rasagiline; oral
10.7
10.8
20
19
I63.2
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
9.7
10.8
21
22
B01AB05
ATC
enoxaparin; parenteral
1.6
10.7
295
2036
M01AE03
ATC
ketoprofen; systemic, rectal
1.6
10.7
343
2457
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.3
10.5
80
362
3378X
ICD-9 Finland
Disorders of the autonomic nervous system[NEUROPATHIA AUTONOMICA PERIPHERICA ALIA DEFINITA]
+∞
10.4
10
*
G23.3
ICD-10 Finland
Multiple system atrophy, cerebellar type [MSA-C]
+∞
10.4
10
*
X58
ICD-10 Finland
Exposure to other specified factors
1.9
10.4
156
907
G43.9
ICD-10 Finland
Migraine, unspecified
2.4
10.4
71
306
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
10.3
190
1175
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
10.7
10.3
19
18
A06AD11
ATC
lactulose; oral
1.9
10.2
141
799
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
10.2
349
2533
J01AA02
ATC
doxycycline; systemic
1.6
10.1
736
6323
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
4.4
10.1
25
58
ZXA05
NOMESCO Finland
Left side
1.7
10.1
225
1468
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
10.0
397
2976
N06AA09
ATC
amitriptyline; systemic
2.1
10.0
93
457
PA7BD
NOMESCO Finland
CT angiography of neck and brain
7.7
9.9
22
29
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
5.2
9.9
20
39
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
2.9
9.9
45
158
N02BE01
ATC
paracetamol; systemic, rectal
1.9
9.8
867
7807
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.6
9.8
56
222
H02AB04
ATC
methylprednisolone; systemic
1.9
9.7
139
795
A02BC01
ATC
omeprazole; systemic
1.6
9.7
251
1698
R11
ICD-10 Finland
Nausea and vomiting
2.1
9.7
95
476
M48.0
ICD-10 Finland
Spinal stenosis
2.0
9.7
118
640
ZXA10
NOMESCO Finland
Bilateral
1.8
9.7
173
1060
IDY03
NOMESCO Finland
Systematic individual therapy, cognitive-behavioural
2.8
9.6
49
183
L17
ICPC
Foot/toe symptom/complaint
1.6
9.6
300
2126
R60.0
ICD-10 Finland
Localized oedema
1.9
9.6
126
702
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.9
9.5
132
749
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.0
9.5
102
530
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
7.6
9.4
21
28
M54.1
ICD-10 Finland
Radiculopathy
2.8
9.4
46
168
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
+∞
9.4
9
*
G93.0
ICD-10 Finland
Cerebral cysts
+∞
9.4
9
*
G99.2*M47.1
ICD-10 Finland
Spondylogenic compression of spinal cord
+∞
9.4
9
*
35800
ICD-8 Finland
Disease of peripheral autonomic nervous system, Syndroma Horner
+∞
9.4
9
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
9.4
309
2214
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
9.3
353
2608
Z50.5
ICD-10 Finland
Speech therapy
4.7
9.3
21
45
M54.3
ICD-10 Finland
Sciatica
2.4
9.3
64
277
Z2445
NOMESCO Finland
Psychologist
2.8
9.3
46
169
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.7
9.3
173
1072
J01DB01
ATC
cefalexin; oral
1.7
9.3
796
7027
S06.0
ICD-10 Finland
Concussion
1.9
9.2
113
614
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
4.2
9.2
24
58
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.8
9.2
154
925
N06AX26
ATC
vortioxetine; oral
2.2
9.2
81
390
R03AC02
ATC
salbutamol; inhalant
1.5
9.2
529
4272
JN3AD
NOMESCO Finland
Abdominal CT examination
1.9
9.2
130
742
XF404
NOMESCO Finland
Ambulatory ECG
2.1
9.1
85
418
M47.9
ICD-10 Finland
Spondylosis, unspecified
3.3
9.1
34
106
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
2.9
9.1
42
149
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
9.0
287
2036
N05BA12
ATC
alprazolam; oral
2.0
9.0
100
525
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.0
9.0
94
483
R1250
NOMESCO Finland
Evaluation of functional capability
3.3
9.0
33
102
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.2
8.9
78
374
S13.4
ICD-10 Finland
Sprain and strain of cervical spine
2.6
8.9
52
208
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.3
8.8
67
303
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
3.3
8.8
32
98
G04BD12
ATC
mirabegron; oral
1.9
8.8
118
661
L29
ICPC
Musculoskeletal sympt/complt other
2.0
8.8
96
501
R03BA05
ATC
fluticasone; inhalant
1.7
8.8
176
1112
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.2
8.8
77
370
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.8
8.8
142
844
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.8
8.7
151
915
N02CC03
ATC
zolmitriptan; nasal, oral
2.4
8.7
62
273
Z3229
NOMESCO Finland
Other healthcare associate professional
2.1
8.6
81
400
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.7
8.5
186
1202
N04BA03
ATC
levodopa, decarboxylase inhibitor and COMT inhibitor; oral
7.4
8.5
19
26
J01MA12
ATC
levofloxacin; systemic
1.7
8.5
167
1050
N02CC04
ATC
rizatriptan; oral
2.3
8.4
63
283
R61.9
ICD-10 Finland
Hyperhidrosis, unspecified
4.9
8.4
18
37
SPAT1221
SPAT
Guidance concerning rehabilitation services and livelihood
3.8
8.4
25
67
G90
ICD-10 Finland
Disorders of autonomic nervous system
+∞
8.3
8
*
G54.0
ICD-10 Finland
Brachial plexus disorders
3.1
8.3
34
112
P01AB01
ATC
metronidazole; oral, rectal
1.5
8.3
367
2788
J01EA01
ATC
trimethoprim; systemic
1.6
8.3
230
1577
R60.9
ICD-10 Finland
Oedema, unspecified
2.3
8.3
59
260
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.1
8.2
83
421
L01
ICPC
Neck symptom/complaint
1.7
8.1
159
997
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.5
8.1
51
212
UKC02
NOMESCO Finland
Cystoscopy
1.7
8.1
144
879
R68.88
ICD-10 Finland
Other specified general symptoms and signs, not elsewhere classified.
6.9
8.1
19
28
G23.9
ICD-10 Finland
Degenerative disease of basal ganglia, unspecified
33.6
8.1
10
*
ZXA00
NOMESCO Finland
Right side
1.6
8.1
234
1620
Z2221
NOMESCO Finland
Medical doctor
1.6
8.1
254
1792
K59.00
ICD-10 Finland
Constipation caused by slow bowel passage (SCT)
3.6
8.0
26
74
M54.4
ICD-10 Finland
Lumbago with sciatica
1.7
8.0
176
1138
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
2.7
8.0
41
154
J01FA10
ATC
azithromycin; systemic
1.5
8.0
534
4393
N06AB06
ATC
sertraline; oral
1.8
8.0
118
682
Z02.7
ICD-10 Finland
Issue of medical certificate
2.1
7.9
78
392
N05CF01
ATC
zopiclone; oral
1.5
7.9
295
2159
J01FA06
ATC
roxithromycin; oral
1.5
7.9
362
2764
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
3.2
7.9
31
100
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.3
7.9
60
272
M25.5
ICD-10 Finland
Pain in joint
1.5
7.9
316
2348
H53.2
ICD-10 Finland
Diplopia
2.9
7.9
36
127
N17
ICPC
Vertigo/dizziness
1.8
7.8
124
731
U05
ICPC
Urination problems other
2.3
7.8
56
247
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.1
7.8
76
380
AEA50
NOMESCO Finland
Adjustment of implanted neurostimulator
10.9
7.8
14
13
N30.9
ICD-10 Finland
Cystitis, unspecified
2.2
7.8
65
306
193
Kela drug reimbursment
Rasagiline
9.5
7.8
15
16
SPAT1240
SPAT
Therapeutic discussion
1.9
7.7
106
598
R52.1
ICD-10 Finland
Chronic intractable pain
6.0
7.7
20
34
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.6
7.7
43
169
N01
ICPC
Headache
1.8
7.7
121
713
Q79.6
ICD-10 Finland
Ehlers-Danlos syndrome
18.5
7.6
11
6
D01
ICPC
Abdominal pain/cramps general
1.8
7.6
123
730
XCK10
NOMESCO Finland
Photography of fundus of eye
2.0
7.6
89
477
W19
ICD-10 Finland
Unspecified fall
1.9
7.6
96
528
R03BA02
ATC
budesonide; inhalant
1.7
7.6
169
1097
Z43.5
ICD-10 Finland
Attention to cystostomy
10.1
7.5
14
14
N07BC02
ATC
methadone; systemic
10.1
7.5
14
14
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.6
7.5
43
171
J31.0
ICD-10 Finland
Chronic rhinitis
1.9
7.5
90
486
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
3.7
7.5
23
63
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.1
7.5
68
332
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
7.5
185
1232
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
4.5
7.4
18
41
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
7.7
7.4
16
21
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
2.2
7.4
65
313
R07.3
ICD-10 Finland
Other chest pain
1.8
7.4
103
585
A04
ICPC
Weakness/tiredness general
1.7
7.3
152
967
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.8
7.3
122
731
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
+∞
7.3
7
*
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.5
7.3
44
180
R06AE07
ATC
cetirizine; oral
1.4
7.2
397
3127
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
3.7
7.2
22
60
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.8
7.2
35
128
E0000UV, ,
ATC
1.5
7.2
384
3008
N03AF01
ATC
carbamazepine; oral, rectal
2.3
7.2
52
231
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
2.7
7.2
36
134
SFA10
NOMESCO Finland
One-surface restoration
1.4
7.1
519
4300
AEA20
NOMESCO Finland
Removal of impulse generator of stimulation device in the nervous system
20.2
7.1
10
5
N05BA01
ATC
diazepam; systemic, rectal
1.8
7.1
121
728
M03BC01
ATC
orphenadrine (citrate); systemic
1.6
7.1
210
1455
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
3.0
7.1
30
101
G44.8
ICD-10 Finland
Other specified headache syndromes
3.8
7.1
21
56
G21.9
ICD-10 Finland
Secondary parkinsonism, unspecified
12.1
7.1
12
10
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.7
7.1
144
911
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
7.1
242
1733
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.4
7.0
46
195
TAC00
NOMESCO Finland
Peripheral nerve block
10.1
7.0
13
13
J02AC01
ATC
fluconazole; systemic
1.5
7.0
347
2675
N18
ICPC
Paralysis/weakness
3.5
7.0
23
66
G50.0
ICD-10 Finland
Trigeminal neuralgia
3.3
7.0
25
76
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.5
7.0
279
2062
J01DA06
ATC
[U] cefuroxime
1.7
7.0
131
811
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.2
6.9
57
267
R05FA02
ATC
opium derivatives and expectorants; systemic
1.5
6.9
348
2690
R01AD09
ATC
mometasone; nasal
1.4
6.9
425
3409
XQ800
NOMESCO Finland
Prick test
2.0
6.9
71
363
K07.63
ICD-10 Finland
Pain in the jaw joint UNS
3.2
6.9
27
87
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.9
6.8
92
516
N03AG01
ATC
valproic acid; systemic, rectal
2.1
6.8
60
289
SPAT1260
SPAT
Consultation of another employee
1.6
6.8
157
1025
S18
ICPC
Laceration/cut
1.4
6.8
436
3521
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
6.8
430
3465
XLA10, ,
NOMESCO Finland
2.4
6.8
44
186
L09
ICPC
Arm symptom/complaint
2.2
6.8
54
250
A06
ICPC
Fainting/syncope
3.7
6.8
21
58
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
4.3
6.8
17
40
TQW40
NOMESCO Finland
Remowal of suture of skin
2.0
6.8
68
345
G43.8
ICD-10 Finland
Other migraine
3.5
6.7
22
63
S80.0
ICD-10 Finland
Contusion of knee
2.0
6.7
77
409
SPAT1284
SPAT
Extensive health certificate
2.9
6.7
31
110
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.0
6.7
75
395
A02BC03
ATC
lansoprazole; oral
1.5
6.7
253
1846
M02AA10
ATC
ketoprofen; topical
1.7
6.7
139
884
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
1.8
6.7
104
610
B01AC07
ATC
dipyridamole; systemic
2.8
6.7
32
116
WX892
NOMESCO Finland
Monitored bed care
2.0
6.7
72
375
P06
ICPC
Sleep disturbance
1.7
6.7
124
766
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.0
6.6
76
404
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.1
6.6
60
293
Z2446
NOMESCO Finland
Social worker
2.0
6.6
68
349
G57.1
ICD-10 Finland
Meralgia paraesthetica
3.9
6.6
19
50
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
3.9
6.6
19
50
R4110, ,
SPAT
1.7
6.6
127
793
TLC00
NOMESCO Finland
Insertion of intrauterine device
2.1
6.5
58
281
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
2.3
6.5
50
228
R01BA51
ATC
phenylpropanolamine, combinations; oral
1.8
6.5
104
615
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
6.5
182
1245
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
6.2
6.5
16
26
AA1BG, ,
SPAT
3.2
6.5
25
80
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
2.2
6.5
54
255
N30.0
ICD-10 Finland
Acute cystitis
1.6
6.4
154
1015
PA6BM
NOMESCO Finland
MRI examination of neck vasculature with 3 Tesla magnet
70.3
6.4
7
*
M03BC51
ATC
orphenadrine, combinations; systemic
1.5
6.4
244
1782
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
2.2
6.4
52
243
R1260
NOMESCO Finland
Evaluation of communicative skills
3.8
6.4
19
51
M54.2
ICD-10 Finland
Cervicalgia
1.9
6.4
81
446
L12
ICPC
Hand/finger symptom/complaint
1.6
6.4
167
1125
G04CA02
ATC
tamsulosin; oral
1.5
6.4
189
1310
R81
ICPC
Pneumonia
2.5
6.4
40
167
F43.21
ICD-10 Finland
Adaptation disorder with prolonged depression
6.6
6.3
15
23
H02AB09
ATC
hydrocortisone; systemic
3.1
6.3
25
81
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.9
6.3
73
389
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
3.6
6.3
20
56
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
3.0
6.3
27
92
N04BC09
ATC
rotigotine; transdermal
9.3
6.3
12
13
C10AA05
ATC
atorvastatin; oral
1.4
6.3
344
2692
Q13.2
ICD-10 Finland
Other congenital malformations of iris
18.1
6.3
9
5
D89.89
ICD-10 Finland
Other specified disorders involving the immune mechanism, not elsewhere classified
+∞
6.3
6
*
PA7CG
NOMESCO Finland
Extended MRI examination of vessesl in brain and neck with high intensity magnet
+∞
6.3
6
*
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
+∞
6.3
6
*
M01AB05
ATC
diclofenac; systemic, rectal
1.4
6.3
603
5198
C08CA05
ATC
nifedipine; systemic
2.1
6.2
54
259
U13
ICPC
Bladder symptom/complaint other
2.8
6.2
31
115
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
2.8
6.2
31
115
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
2.3
6.2
47
213
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
1.8
6.2
94
547
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
2.3
6.2
43
188
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
6.3
6.2
15
24
U09
ICD-10 Finland
Post COVID-19 condition
6.3
6.2
15
24
A99
ICPC
Disease/condition unspecnature/site
1.8
6.2
101
602
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.8
6.1
100
595
R1210
NOMESCO Finland
Medical assessment of need and possibilities to rehabilitation
4.2
6.1
16
39
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
2.2
6.1
49
228
SPAT1216
SPAT
Assessment of functional ability
1.7
6.1
128
817
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
3.1
6.1
24
78
N07AA02
ATC
pyridostigmine; systemic
8.7
6.1
12
14
D09
ICPC
Nausea
2.2
6.1
51
242
A07AA02
ATC
nystatin; oral
2.1
6.0
55
269
AEA24
NOMESCO Finland
Removal of spinal stimulation elecrode
10.1
6.0
11
11
EP1BG
NOMESCO Finland
MRI examination of soft tissue of neck with high intesity magnet
10.1
6.0
11
11
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
3.0
6.0
26
89
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
3.5
6.0
20
58
ABC30
NOMESCO Finland
Decompression of cervical nerve roots
6.1
6.0
15
25
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
6.0
378
3025
ZY010
NOMESCO Finland
Hospital outpatient
2.1
6.0
54
263

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
458
2479
2.57
45.63
2.7
2.1
178.70
274.81
u/l
1.14
435
2345
198
839
2.70
31.00
2.4
1.9
397.36
384.03
nmol/l
0.34
185
788
568
3796
2.16
30.37
7.8
6.6
1.21
1.21
mmol/l
0.52
527
3505
551
3694
2.10
28.54
5.6
5.1
35.94
35.93
g/l
0.02
516
3468
607
4250
2.10
27.61
8.7
7.2
1.22
1.21
mmol/l
0.43
526
3676
679
4965
2.16
27.44
6.3
4.9
6.49
6.65
mmol/l
1.28
653
4679
552
3739
2.07
27.38
11.9
13.9
1.18
1.24
inr
2.04
466
3084
413
2526
2.09
26.95
4.5
4.2
7.40
7.40
ph
0.61
298
1790
238
1175
2.35
26.52
2.2
2.0
30.12
29.41
s
0.55
231
1140
452
2896
2.03
25.61
7.0
6.2
—
—
—
0
0
40
61
6.79
25.26
1.1
1.1
0.42
1.09
nmol/l
—
7
8
590
4185
2.01
24.69
7.4
6.4
27.42
27.94
%
0.57
567
3989
611
4416
1.99
23.89
7.4
6.3
0.04
0.04
e9/l
0.93
544
3809
576
4083
1.98
23.78
7.4
6.4
2.79
2.84
%
0.22
549
3833
576
4085
1.97
23.73
7.5
6.5
0.65
0.69
%
0.96
551
3838
609
4404
1.99
23.68
7.4
6.2
0.57
0.58
e9/l
0.26
538
3793
576
4088
1.97
23.64
7.5
6.5
8.72
8.84
%
0.49
549
3851
617
4501
1.98
23.16
7.4
6.3
1.84
1.93
e9/l
1.36
559
3982
624
4573
1.98
23.07
7.7
6.5
0.19
0.19
e9/l
0.01
564
4003
577
4129
1.95
22.75
7.5
6.3
57.75
57.17
%
0.60
561
3956
250
1333
2.17
22.74
2.8
2.5
2.35
2.32
g/l
0.37
235
1243
233
1219
2.19
22.17
2.9
2.6
22.73
23.08
%
0.14
220
1144
235
1241
2.17
21.80
1.5
1.4
504.00
471.85
titre
0.07
45
270
654
4945
1.94
21.15
10.4
9.7
4.31
4.11
e9/l
0.98
584
4309
258
1428
2.09
21.10
3.0
2.5
12.75
13.25
umol/l
0.52
248
1329
364
2276
1.95
21.09
4.0
3.1
—
0.00
estimate
—
0
11
368
2311
1.94
21.04
4.7
4.2
—
—
—
0
0
417
2748
1.89
20.44
4.2
3.3
31.57
97.44
e6/l
1.64
316
2093
56
143
4.09
19.89
1.4
1.2
—
—
—
0
0
33
53
6.41
19.83
1.1
1.1
45.16
31.42
mg/l
0.75
28
42
57
149
4.00
19.62
1.4
1.1
28.83
11.29
e6/l
0.40
46
106
57
151
3.94
19.26
1.5
1.2
986.20
1396.61
e6/l
0.15
50
113
370
2392
1.87
18.90
4.1
3.2
0.40
0.37
e6/l
0.09
267
1753
595
4504
1.80
17.59
6.8
6.6
10.90
11.45
umol/l
0.51
563
4292
57
164
3.63
17.12
1.3
1.1
3.67
3.73
mmol/l
0.16
52
155
454
3203
1.77
16.84
5.1
3.9
42.30
96.50
e6/l
2.37
323
2220
189
1008
2.08
16.68
1.9
1.6
—
—
—
0
0
309
1962
1.83
16.23
2.0
1.7
1.58
1.19
mg/l
0.28
234
1528
36
76
4.88
16.22
1.4
1.3
—
—
—
0
0
297
1865
1.84
16.16
3.3
2.7
7.96
5.72
e6/l
0.33
265
1705
443
3141
1.74
15.86
4.2
3.6
23.19
83.75
ng/l
1.38
291
2158
776
6470
1.91
15.65
10.1
8.2
80.16
78.82
u/l
0.32
744
6128
363
2448
1.76
15.40
1.9
1.7
19.55
20.33
nmol/l
0.49
322
2085
35
77
4.67
15.03
1.4
1.3
2.59
2.79
g/l
0.35
30
59
35
77
4.67
15.03
1.4
1.3
5.58
6.90
g/l
1.32
30
60
35
77
4.67
15.03
1.4
1.3
0.26
0.37
g/l
1.51
30
59
115
536
2.30
14.13
4.8
3.6
4.55
4.59
pmol/l
0.15
102
475
137
687
2.15
14.08
3.3
2.8
9.59
10.83
g/l
3.87
126
638
243
1489
1.84
14.03
3.5
2.9
0.79
0.99
e6/l
0.85
136
783
519
3930
1.67
13.93
2.9
2.5
78.62
76.34
nmol/l
1.05
477
3565
254
1582
1.81
13.88
4.8
3.7
58.37
416.56
ng/l
5.12
190
1202
686
5594
1.73
13.88
6.8
4.5
1493.70
1815.23
e6/l
—
10
74
262
1649
1.80
13.82
3.5
2.9
537.22
535.66
mosm/kgh2o
0.04
223
1458
409
2927
1.67
13.53
3.3
3.4
2.34
2.35
mmol/l
1.33
375
2661
25
45
5.67
13.41
1.2
1.2
0.53
0.52
ratio
0.12
15
24
333
2278
1.69
12.94
2.7
2.2
2.74
2.85
mg/l
0.40
292
1964
232
1433
1.81
12.93
3.9
3.2
0.83
0.82
mmol/l
0.65
225
1356
367
2593
1.66
12.51
7.2
6.2
—
—
—
0
0
166
934
1.93
12.36
8.0
8.3
1.34
1.05
mmol/l
0.40
136
770
121
608
2.13
12.32
1.5
1.3
113.04
191.17
u/ml
1.49
108
568
73
295
2.59
12.23
1.3
1.3
—
—
—
0
0
223
1385
1.79
12.12
3.8
3.0
5.18
2.43
e6/l
0.91
115
674
491
3758
1.61
11.94
2.6
2.1
96.15
96.18
pmol/l
0.01
282
1998
541
4247
1.60
11.76
4.0
3.1
116.80
124.47
ug/l
0.26
511
3993
194
1166
1.82
11.72
1.3
1.2
—
—
—
0
0
35
94
3.82
11.64
1.2
1.5
21.33
25.20
ng/l
0.42
35
94
30
72
4.27
11.59
1.5
1.1
—
—
—
0
0
44
139
3.27
11.49
1.4
1.7
0.62
0.76
g/l
0.39
35
115
165
948
1.89
11.49
8.3
8.3
5.29
5.13
kpa
0.77
160
912
165
948
1.89
11.49
8.3
8.3
12.73
12.21
kpa
0.53
160
915
484
3715
1.59
11.46
4.1
3.3
6.17
6.21
ph
0.25
255
2083
215
1350
1.76
11.16
1.8
1.7
1124.53
1186.70
nmol/l
0.49
169
1019
768
6617
1.70
11.05
5.6
4.4
14.81
14.72
pmol/l
0.47
722
6107
498
3871
1.57
11.01
12.8
11.1
0.01
0.00
e9/l
0.46
407
3153
163
945
1.87
11.01
8.3
8.3
7.41
7.42
ph
0.23
80
537
578
4669
1.57
10.65
4.9
3.8
0.00
0.34
estimate
0.53
117
925
342
2453
1.60
10.58
2.9
3.1
778.82
1256.95
ng/l
3.99
295
2070
575
4645
1.56
10.54
4.8
3.7
0.00
8.32
estimate
1.58
123
982
101
504
2.12
10.45
3.4
4.3
24.68
24.17
mmol/l
0.97
101
499
301
2099
1.62
10.43
2.5
2.3
—
—
—
0
0
125
675
1.97
10.43
2.4
3.1
65.78
67.22
g/l
1.38
114
625
569
4596
1.56
10.36
4.8
3.7
0.01
0.00
estimate
0.41
123
972
352
2556
1.58
10.27
4.3
3.0
—
—
—
0
0
79
363
2.28
10.01
1.8
1.9
13.90
7.47
iu/ml
0.39
23
79
76
346
2.30
9.85
1.4
1.2
0.38
1.38
u/ml
—
5
23
297
2090
1.60
9.81
1.4
1.3
5.65
1.46
u/ml
1.01
75
558
33
96
3.52
9.81
1.5
1.3
—
—
nmol/l
—
0
0
367
2715
1.56
9.75
3.3
2.6
52.73
61.40
u/l
2.35
345
2520
140
804
1.86
9.69
2.6
2.3
0.22
0.21
g/l
0.96
129
750
37
117
3.25
9.67
1.5
1.4
—
0.70
nmol/l
—
0
8
374
2794
1.54
9.44
2.7
2.3
—
—
—
0
0
119
657
1.92
9.28
1.3
1.2
104.98
142.41
u/ml
0.43
46
269
106
563
1.99
9.25
2.1
1.8
1.24
1.53
g/l
1.08
96
522
141
826
1.82
9.14
2.8
2.4
32.05
34.05
u/l
0.26
125
693
386
2926
1.52
9.00
3.8
3.3
38.55
32.59
u/l
0.89
371
2773
35
112
3.20
8.99
1.5
1.3
0.51
0.62
nmol/l
1.32
35
106
242
1654
1.61
8.90
2.9
2.9
2.45
2.45
mmol/l
0.37
219
1483
265
1864
1.57
8.60
1.9
1.5
2.05
2.40
g/l
2.67
171
1155
152
927
1.76
8.59
3.2
2.7
1.75
1.84
%
0.46
139
842
63
282
2.32
8.51
1.8
2.3
124.72
530.47
ug/l
1.56
57
273
32
101
3.24
8.41
1.3
1.3
0.17
0.37
nmol/l
0.53
27
76
917
8491
2.02
8.33
26.0
17.4
139.66
139.68
mmol/l
0.14
907
8316
917
8502
2.00
8.13
26.2
17.6
3.95
3.97
mmol/l
1.02
905
8307
124
726
1.81
8.03
9.5
9.0
—
—
—
0
0
181
1178
1.66
8.03
2.5
2.5
97.73
114.71
ug/g
0.50
146
941
906
8372
1.92
8.03
24.2
15.0
22.88
24.09
mg/l
0.48
796
6875
105
587
1.88
7.88
4.1
4.1
7.41
7.42
ph
0.47
91
493
86
450
2.00
7.83
10.2
11.1
16.24
15.94
%
0.46
86
433
222
1528
1.58
7.82
1.4
1.3
2.23
10.81
u/ml
5.79
72
588
858
7816
1.71
7.80
7.0
5.3
1.90
1.88
mu/l
0.06
809
7254
300
2210
1.51
7.77
3.1
2.7
329.00
344.07
umol/l
1.74
259
1963
237
1663
1.56
7.66
1.5
1.3
42.40
31.57
iu/ml
0.34
65
497
136
835
1.73
7.48
3.7
4.0
1.80
1.79
mmol/l
0.02
122
711
46
190
2.49
7.43
1.3
1.2
254.14
226.88
u/ml
0.29
35
105
185
1233
1.61
7.43
2.2
2.0
—
—
—
0
0
139
863
1.71
7.34
3.8
3.9
7.38
7.38
ph
0.11
72
488
60
282
2.20
7.25
2.0
2.5
9.59
10.90
g/l
1.40
50
254
98
551
1.86
7.22
2.3
2.8
—
—
—
0
0
24
70
3.49
7.15
2.1
2.4
20.67
20.66
nmol/l
0.00
24
63
139
872
1.69
7.06
3.7
3.9
5.90
5.82
kpa
0.43
134
847
490
4032
1.42
6.92
3.0
2.7
—
—
estimate
—
0
0
329
2517
1.46
6.91
3.3
2.9
0.60
0.00
—
5
52
172
1147
1.60
6.86
7.0
5.9
1.05
1.04
mmol/l
0.13
162
1062
40
161
2.55
6.83
1.7
1.5
161.00
164.40
au/ml
0.07
11
46
121
742
1.72
6.67
7.0
7.5
7.76
9.81
mmol/l
3.09
116
715
247
1799
1.50
6.61
2.1
2.0
—
—
—
0
0
79
428
1.92
6.53
2.3
2.1
0.24
0.01
estimate
0.76
25
144
42
179
2.41
6.38
1.7
1.5
—
—
—
0
0
238
1734
1.49
6.33
1.8
1.7
439.34
32944831.70
pmol/l
1.91
204
1457
153
1013
1.60
6.27
3.4
2.8
8.60
7.27
umol/l
0.32
128
897
125
792
1.66
6.10
2.3
2.1
0.13
0.02
estimate
0.55
30
175
48
225
2.19
5.88
2.6
3.1
1.70
1.94
index
0.14
30
125
100
603
1.73
5.86
2.6
2.9
149.48
210.00
ng/l
0.62
89
552
661
5827
1.40
5.76
4.2
3.3
47.25
47.34
u/l
0.01
622
5504
358
2855
1.40
5.75
3.7
3.5
—
0.70
—
0
10
413
3386
1.38
5.56
2.2
2.1
—
—
—
0
0
54
272
2.04
5.52
1.7
1.4
10.04
8.81
u/l
0.23
38
223
17
47
3.66
5.50
1.7
3.1
700.41
713.55
u/ml
0.02
17
47
114
725
1.65
5.48
1.2
1.2
—
—
—
0
0
44
206
2.19
5.42
1.8
2.3
136.57
130.44
g/l
0.90
37
162
114
729
1.64
5.37
1.5
1.5
—
—
—
0
0
159
1103
1.53
5.28
1.7
1.6
—
—
—
0
0
22
74
3.02
5.28
1.6
1.2
—
—
—
0
0
36
158
2.33
5.17
2.3
3.5
2.54
2.66
mmol/l
0.10
24
105
19
60
3.21
5.06
1.7
1.6
9.61
12.11
umol/l
1.26
19
54
50
254
2.02
5.01
1.9
2.0
6.00
4.13
iu/l
0.40
19
101
62
340
1.88
4.99
1.9
1.7
330.53
285.24
mu/l
0.46
56
311
51
264
1.98
4.86
2.5
1.7
—
—
—
0
0
157
1107
1.50
4.82
1.5
1.4
—
—
—
0
0
78
465
1.74
4.78
1.3
1.2
—
—
—
0
0
110
718
1.60
4.77
2.8
2.8
71.77
72.00
e9/l
0.02
78
522
17
55
3.13
4.37
1.6
1.5
5.97
6.79
ug/l
0.22
17
47
15
45
3.37
4.33
1.2
1.3
159.56
153.65
nmol/l
0.19
15
45
63
365
1.78
4.28
2.8
2.2
1375.34
5218.74
u/l
1.41
16
153
62
358
1.78
4.26
2.1
2.0
1.40
1.49
g/l
0.35
54
322
32
146
2.23
4.25
1.3
1.3
77.96
62.37
mmol/l
0.97
26
125
48
256
1.92
4.23
1.6
1.2
2.41
5.22
u/ml
—
10
40
9
13
6.97
4.17
1.2
1.0
9.29
5.71
mg/g
—
9
13
24
98
2.48
4.07
1.3
1.3
282.39
279.42
mosm/kgh2o
0.28
18
73
311
2535
1.33
4.06
5.3
3.8
0.00
0.01
estimate
1.15
114
912
37
183
2.06
4.03
2.4
3.7
—
—
—
0
0
69
418
1.70
4.03
4.6
4.3
—
—
—
0
0
9
14
6.48
3.99
1.2
1.0
—
—
—
0
0
649
5854
1.31
3.98
4.5
3.9
—
7770.69
—
0
13
45
241
1.91
3.94
1.2
1.2
—
—
—
0
0
47
257
1.87
3.87
1.4
1.4
343.38
304.03
ug/g
0.54
26
155
55
316
1.78
3.87
1.5
1.3
—
—
—
0
0
8
11
7.32
3.86
1.1
1.3
—
—
—
0
0
97
648
1.55
3.84
4.4
3.9
72.83
88.07
ng/l
0.88
86
563
29
133
2.22
3.83
1.3
1.2
—
—
—
0
0
29
133
2.22
3.83
1.6
1.3
33.01
22.58
u/l
0.78
24
112
66
401
1.69
3.82
1.7
1.7
0.33
0.34
mg/l
0.03
27
189
37
189
1.99
3.72
1.7
1.2
—
—
—
0
0
12
29
4.18
3.71
1.2
1.1
—
—
—
0
0
12
29
4.18
3.71
1.2
1.1
—
—
—
0
0
12
29
4.18
3.71
1.2
1.1
—
—
—
0
0
24
104
2.34
3.61
1.6
1.2
—
—
—
0
0
46
256
1.84
3.60
1.6
1.2
1.22
1.95
u/ml
—
6
23
925
8877
1.60
3.55
28.2
19.4
75.40
76.64
umol/l
0.50
919
8771
139
1016
1.43
3.54
1.4
1.4
—
—
—
0
0
97
661
1.52
3.52
3.3
3.8
1.21
1.23
mmol/l
1.12
86
566
55
326
1.73
3.50
1.6
1.6
23.29
8.21
u/ml
0.80
15
79
50
290
1.76
3.44
2.9
2.5
—
—
—
0
0
309
2566
1.30
3.43
4.1
3.2
0.03
0.05
estimate
0.14
101
768
12
32
3.78
3.39
1.2
1.5
—
—
—
0
0
44
247
1.82
3.37
1.1
1.1
—
—
—
0
0
17
65
2.64
3.31
1.0
1.2
—
—
—
0
0
10
23
4.38
3.31
1.0
1.3
83.87
72.70
nmol/24h
—
10
23
46
758
0.59
3.15
1.7
1.7
3.28
3.46
mmol/l
0.58
33
540
405
3510
1.26
3.12
5.0
3.6
0.06
0.04
estimate
0.21
102
806
87
596
1.50
3.10
1.1
1.2
—
—
—
0
0
14
50
2.83
3.09
1.2
1.2
—
—
—
0
0
40
225
1.81
3.07
1.3
1.2
—
—
—
0
0
26
126
2.09
3.04
1.3
1.3
3.87
5.89
u/ml
0.40
16
53
12
36
3.36
3.02
2.0
1.4
0.00
0.08
estimate
0.49
12
36
9
21
4.31
3.00
1.2
1.1
—
—
—
0
0
248
2039
1.29
2.92
5.1
3.7
1.02
1.02
kg/l
0.84
167
1337
18
76
2.39
2.90
1.2
1.2
109.44
110.59
pmol/l
0.04
18
76
90
631
1.47
2.88
2.5
2.4
4.90
7.46
ug/l
1.01
75
564
6
9
6.70
2.87
1.0
1.0
—
—
—
0
0
108
788
1.42
2.80
3.4
4.7
0.78
0.95
%
0.33
32
245
99
711
1.44
2.80
5.0
3.7
—
—
—
0
0
68
453
1.54
2.78
2.9
2.9
0.55
0.62
%
1.74
68
453
13
48
2.73
2.72
1.2
1.8
—
—
—
0
0
23
112
2.08
2.69
1.4
1.1
—
—
—
0
0
242
2008
1.27
2.63
4.9
4.8
—
—
—
0
0
12
41
2.95
2.62
1.7
1.3
128.12
169.56
mmol/24h
1.15
12
41
104
765
1.40
2.59
3.6
5.0
0.08
0.17
%
0.60
26
190
24
121
2.01
2.57
1.2
1.5
—
—
—
0
0
24
121
2.01
2.57
1.2
1.5
—
—
—
0
0
24
121
2.01
2.57
1.2
1.5
—
—
—
0
0
24
121
2.01
2.57
1.2
1.5
—
—
—
0
0
27
484
0.55
2.55
1.4
1.6
843.73
971.78
mu/l
0.43
20
409
901
8678
1.40
2.55
19.6
13.4
—
—
—
0
0
58
383
1.55
2.49
2.3
2.0
—
—
—
0
0
103
762
1.39
2.49
5.3
4.0
7.35
7.36
ph
0.17
72
552
18
82
2.22
2.48
9.5
6.0
72.72
34.95
u/ml
—
8
28
8
21
3.83
2.46
3.3
2.7
23.19
16.71
umol/l
—
8
21
102
755
1.39
2.46
3.3
4.5
0.54
0.65
%
0.19
28
226
296
3423
0.81
2.46
3.1
3.1
—
—
—
0
0
35
206
1.72
2.36
1.1
1.1
0.96
2.33
u/ml
0.99
21
111
70
488
1.47
2.34
1.6
1.4
22.28
24.99
iu/l
0.35
55
427
101
753
1.38
2.34
3.5
4.8
0.04
0.12
%
0.98
25
208
18
85
2.14
2.29
2.7
4.8
10.20
10.51
%
0.11
18
85
188
1537
1.28
2.29
1.8
1.7
—
—
—
0
0
31
178
1.77
2.28
2.2
2.1
—
—
—
0
0
28
156
1.82
2.27
7.2
9.5
12.00
11.38
mmol/l
0.19
28
141
39
240
1.65
2.25
1.1
1.1
20.02
4.70
eliau/ml
—
5
28
818
7800
1.27
2.25
6.9
6.2
39.17
38.96
mmol/mol
0.26
777
7333
28
157
1.81
2.23
7.3
9.4
104.75
105.27
mmol/l
0.18
28
142
97
727
1.37
2.19
1.4
1.4
—
—
—
0
0
7
19
3.70
2.15
1.3
1.6
—
—
—
0
0
11
42
2.64
2.14
1.0
1.0
1136.09
1562.43
miu/ml
0.60
11
42
34
209
1.65
2.00
1.5
1.2
23.98
39.90
u/ml
—
6
21
48
321
1.52
1.99
1.9
1.8
—
—
—
0
0
18
91
2.00
1.96
2.6
2.4
—
—
—
0
0
27
157
1.74
1.94
1.0
1.1
1.03
3.38
u/ml
1.70
18
75
6
16
3.77
1.93
1.5
1.3
71.67
68.81
ug/l
—
6
16
30
181
1.68
1.90
1.1
1.1
4.14
6.73
u/ml
0.63
18
99
39
252
1.57
1.89
3.5
4.0
1.79
4.01
ratio
0.82
23
146
7
22
3.20
1.88
1.1
1.1
—
—
—
0
0
8
28
2.87
1.86
2.6
1.6
28.50
32.21
%
—
8
28
19
100
1.92
1.86
1.2
1.3
—
—
—
0
0
16
79
2.04
1.86
2.9
3.5
17.36
12.06
index
0.87
11
52
29
175
1.68
1.84
1.1
1.1
0.56
1.63
u/ml
0.72
14
74
89
678
1.34
1.84
2.8
2.6
6.11
6.10
ph
0.07
58
456
25
145
1.74
1.82
1.2
1.1
—
—
—
0
0
20
108
1.87
1.82
2.4
2.5
—
22.50
—
0
12
14
66
2.14
1.82
1.3
1.1
—
—
—
0
0
29
176
1.67
1.81
1.3
1.8
—
—
—
0
0
333
2958
1.19
1.80
3.5
3.4
7.83
7.85
mmol/l
0.03
279
2523
7
23
3.06
1.80
1.1
1.0
—
—
—
0
0
15
282
0.52
1.73
1.2
1.6
56.88
61.64
ug/l
—
10
241
7
24
2.93
1.72
5.0
3.9
—
—
—
0
0
29
179
1.64
1.71
1.1
1.1
0.41
1.88
u/ml
1.99
16
90
393
3556
1.17
1.69
2.0
1.9
1.40
1.36
mmol/l
0.31
321
3027
20
112
1.80
1.65
1.1
1.2
—
—
—
0
0
16
83
1.94
1.65
1.3
1.2
0.01
2.13
u/ml
—
10
42
23
135
1.72
1.63
1.0
1.0
0.07
0.28
u/ml
—
9
43
5
14
3.58
1.61
1.0
1.0
—
—
—
0
0
5
14
3.58
1.61
1.0
1.0
—
—
—
0
0
5
14
3.58
1.61
1.0
1.0
—
—
—
0
0
905
8810
1.30
1.61
15.5
11.7
26.34
26.18
u/l
0.08
887
8560
14
70
2.01
1.59
1.3
1.1
—
—
—
0
0
21
121
1.75
1.59
8.5
5.6
10.49
11.56
mg/l
0.57
21
111
37
252
1.49
1.47
1.2
1.1
—
—
—
0
0
22
132
1.68
1.47
1.0
1.0
1.49
1.99
eliau/ml
—
8
55
50
362
1.40
1.45
1.3
1.3
—
—
—
0
0
11
52
2.13
1.44
1.7
3.6
0.45
0.90
index
1.65
11
52
134
1114
1.23
1.44
3.2
3.2
4.14
4.97
e9/l
0.84
112
991
26
164
1.60
1.44
2.1
3.3
5.89
8.41
pmol/l
1.13
26
164
6
22
2.74
1.43
1.3
1.7
—
—
—
0
0
52
381
1.38
1.42
2.1
1.8
—
—
—
0
0
21
127
1.67
1.37
3.1
2.7
—
—
—
0
0
287
2571
1.16
1.36
4.9
5.3
2.17
2.79
ug/l
0.79
257
2323
302
2716
1.16
1.36
3.6
3.5
42.73
51.92
mg/l
0.40
193
1754
5
17
2.95
1.36
1.0
1.0
1.82
7.59
u/ml
—
5
17
13
68
1.92
1.33
1.0
1.0
—
—
—
0
0
24
152
1.59
1.32
1.1
1.1
—
—
—
0
0
6
24
2.51
1.30
1.5
1.2
—
0.50
—
0
5
828
8020
1.19
1.30
5.4
4.9
5.94
5.90
mmol/l
0.27
766
7388
54
405
1.35
1.29
2.1
1.8
—
—
—
0
0
46
336
1.39
1.29
6.7
6.2
0.97
0.87
%
1.06
46
315
306
2766
1.15
1.28
4.3
4.2
9.45
8.96
mg/mmol
0.06
193
1749
741
7116
1.16
1.28
29.7
19.3
331.99
332.43
g/l
0.70
735
7067
54
406
1.35
1.28
2.1
1.8
—
—
—
0
0
103
848
1.24
1.23
3.3
4.6
2.88
21.44
ug/l
1.28
81
695
54
409
1.34
1.23
2.1
1.8
—
—
—
0
0
108
895
1.23
1.22
1.7
1.5
—
—
—
0
0
10
49
2.05
1.22
1.0
1.2
—
—
—
0
0
22
140
1.58
1.21
1.1
1.1
—
—
—
0
0
17
101
1.70
1.20
1.1
1.1
—
—
—
0
0
50
376
1.35
1.19
6.1
5.8
1.67
1.55
%
0.59
50
357
15
86
1.76
1.19
3.7
2.1
—
—
—
0
0
132
1120
1.21
1.19
1.4
1.3
—
—
—
0
0
12
212
0.56
1.19
1.2
1.5
1.03
1.27
mm
—
7
158
16
94
1.71
1.18
1.2
1.1
—
—
—
0
0
5
20
2.51
1.15
1.0
1.2
—
—
—
0
0
13
220
0.59
1.11
1.2
1.6
—
—
—
0
0
25
168
1.50
1.10
1.2
1.1
5.88
17.04
au/ml
—
5
50
7
32
2.20
1.08
2.7
3.2
—
—
—
0
0
13
215
0.60
1.03
1.2
1.5
—
—
—
0
0
22
147
1.51
1.01
1.0
1.1
2.35
5.84
u/ml
0.94
13
61
20
131
1.54
1.00
1.8
1.9
—
—
—
0
0
7
35
2.01
1.00
2.7
3.0
—
—
—
0
0
7
35
2.01
1.00
1.6
1.8
108.57
69.10
ug/l
—
7
35
89
742
1.22
0.98
3.0
2.4
16.27
13.13
nmol/l
0.84
81
671
52
407
1.29
0.98
2.1
1.7
—
—
—
0
0
27
190
1.43
0.97
1.7
2.4
70.75
131.45
ug/min
0.60
18
107
12
73
1.65
0.82
1.5
1.7
6.98
6.45
mmol/l
0.22
12
49
21
148
1.43
0.78
2.8
3.4
3.97
4.18
e9/l
0.23
21
148
16
232
0.68
0.75
1.6
1.3
—
—
—
0
0
12
75
1.61
0.75
1.5
1.1
—
—
—
0
0
11
68
1.62
0.72
1.2
1.1
—
—
—
0
0
27
354
0.76
0.71
1.0
1.1
1.53
1.52
g/l
0.05
27
354
114
1005
1.15
0.71
1.8
1.8
—
—
—
0
0
74
864
0.84
0.70
1.4
1.4
—
—
—
0
0
9
58
1.56
0.70
1.1
1.2
—
—
—
0
0
170
1542
1.12
0.69
2.9
3.1
0.68
0.75
ug/l
0.59
108
975
5
92
0.54
0.67
1.0
1.1
—
—
—
0
0
13
86
1.52
0.66
1.3
1.3
38827.83
38671.98
e6/l
—
6
47
14
95
1.48
0.64
1.3
1.3
2300.14
1474.25
e6/l
—
7
63
13
87
1.50
0.63
1.5
1.6
—
—
—
0
0
12
79
1.53
0.62
1.3
1.3
—
—
—
0
0
13
88
1.48
0.60
1.3
1.4
—
—
—
0
0
29
366
0.79
0.60
1.0
1.2
0.93
0.91
g/l
0.09
29
366
39
319
1.23
0.58
2.1
4.0
291.27
311.98
mg/l
0.07
11
139
42
347
1.22
0.57
1.0
1.1
—
—
—
0
0
40
329
1.22
0.56
1.3
1.3
184.69
247.68
miu/ml
0.51
12
162
32
257
1.25
0.56
1.2
1.2
—
567.14
—
0
7
6
37
1.63
0.55
2.3
2.9
25.95
246.96
ug/l
—
6
31
15
107
1.41
0.55
1.5
2.9
0.36
1.22
g/24h
—
6
66
6
38
1.58
0.54
1.2
1.1
—
—
—
0
0
40
331
1.22
0.54
2.9
2.5
—
—
—
0
0
6
41
1.47
0.50
58.2
37.8
7.45
6.98
ug/l
—
6
36
10
67
1.50
0.49
2.1
2.7
44.80
39.89
%
—
5
35
7
47
1.49
0.47
1.4
2.6
528.14
505.26
min
—
7
31
25
200
1.26
0.46
2.8
3.2
57.28
57.25
%
0.01
25
200
16
209
0.76
0.45
5.2
4.3
—
—
—
0
0
7
51
1.38
0.44
1.3
1.4
143.86
166.71
pmol/l
—
7
51
925
9166
1.13
0.42
35.2
23.0
253.06
251.26
e9/l
0.37
915
8987
0
15
0.00
0.41
0.0
5.7
—
8.01
—
0
15
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
3.1
—
—
—
0
0
925
9169
1.13
0.40
35.0
22.9
91.16
90.87
fl
1.17
919
9071
925
9170
1.12
0.40
35.0
22.9
30.33
30.27
pg
0.46
919
9072
925
9170
1.12
0.40
35.9
23.4
40.20
40.42
%
0.74
918
9067
925
9170
1.12
0.40
35.1
22.9
4.45
4.51
e12/l
2.96
911
8968
0
18
0.00
0.40
0.0
3.2
—
—
—
0
0
5
36
1.39
0.38
2.8
2.3
—
—
—
0
0
925
9173
1.12
0.38
35.3
23.1
133.77
135.44
g/l
2.82
919
9075
924
9170
1.11
0.33
35.2
23.0
6.93
6.74
e9/l
0.96
913
8962
22
182
1.21
0.33
1.1
1.1
—
—
—
0
0
11
83
1.33
0.32
2.4
2.7
—
—
—
0
0
25
213
1.18
0.29
1.4
1.7
22968.29
11963.75
e6/l
0.31
17
151
97
1036
0.93
0.26
1.6
1.5
—
—
—
0
0
15
124
1.21
0.24
2.9
2.8
—
—
—
0
0
12
97
1.24
0.23
2.1
1.3
—
—
—
0
0
5
39
1.28
0.23
1.0
1.6
—
—
—
0
0
14
167
0.84
0.21
1.6
1.7
—
—
—
0
0
21
182
1.16
0.21
1.1
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
4.60
—
0
5
5
43
1.16
0.21
1.4
1.5
—
—
—
0
0
11
90
1.22
0.19
1.5
4.3
—
—
—
0
0
7
60
1.17
0.18
1.0
1.1
—
—
—
0
0
7
60
1.17
0.18
1.6
2.4
567.71
642.25
ml
—
7
36
817
8227
0.96
0.17
5.4
4.8
1.45
1.46
mmol/l
0.13
759
7653
49
459
1.07
0.15
1.4
1.6
—
—
—
0
0
10
118
0.85
0.14
3.7
2.0
12.61
13.20
%
—
10
118
42
395
1.07
0.12
2.9
2.3
—
—
—
0
0
106
1025
1.04
0.11
1.6
1.7
—
—
—
0
0
18
163
1.11
0.11
1.2
1.2
—
—
—
0
0
262
2576
1.02
0.10
1.5
1.5
—
—
—
0
0
5
44
1.14
0.10
1.2
1.1
134.18
155.37
iu/ml
—
5
44
6
55
1.09
0.09
1.5
3.1
8.57
8.63
mmol/l
—
6
55
7
66
1.06
0.08
2.0
1.5
89.43
80.14
umol/l
—
7
66
8
93
0.86
0.06
2.3
2.3
—
—
—
0
0
835
8375
0.98
0.06
6.1
5.5
2.69
2.73
mmol/l
0.63
779
7807
824
8260
0.99
0.04
5.4
4.9
4.59
4.65
mmol/l
0.79
770
7730
47
461
1.02
0.02
1.2
1.1
—
—
—
0
0
783
7838
1.00
0.01
4.5
4.1
1.31
1.29
mmol/l
0.42
721
7231
10
104
0.96
0.00
2.3
2.5
4.14
4.05
mmol/l
—
10
104
10
104
0.96
0.00
2.3
2.5
107.00
105.53
mmol/l
—
10
104
10
102
0.98
0.00
2.3
2.5
1.19
1.19
mmol/l
—
10
102
15
149
1.01
0.00
1.7
1.7
—
—
—
0
0
11
109
1.01
0.00
2.3
2.3
30.73
32.57
pg
0.49
11
109
23
235
0.98
0.00
14.3
9.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.4
—
106.20
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
6
66
0.91
-0.00
2.5
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
64.11
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
176.33
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
4.3
—
0.21
—
0
8
11
110
1.00
-0.00
1.3
1.4
5.42
7.38
mmol/l
2.38
11
93
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
83
0.96
-0.00
1.8
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.3
—
3.33
—
0
7
0
5
0.00
-0.00
0.0
3.2
—
215.00
—
0
5
8
83
0.96
-0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
31.33
—
0
6

Mortality – FinRegistry

Association

Association between endpoint G6_AUTONOM and mortality.

Females

Parameter HR [95% CI] p-value
G6_AUTONOM 2.775 [2.37, 3.25] < 0.001
Birth year 0.994 [0.99, 1.0] 0.162

During the follow-up period (1.1.1998 — 31.12.2019), 671 out of 2348 females with G6_AUTONOM died.

Males

Parameter HR [95% CI] p-value
G6_AUTONOM 2.517 [2.17, 2.92] < 0.001
Birth year 0.988 [0.98, 1.0] 0.013

During the follow-up period (1.1.1998 — 31.12.2019), 798 out of 2520 males with G6_AUTONOM died.

Mortality risk

Mortality risk for people of age

years, who have G6_AUTONOM.

N-year risk Females Males
1 0.269% 0.529%
5 1.548% 2.991%
10 3.906% 7.184%
15 7.323% 13.304%
20 12.638% 22.103%

Relationships between endpoints

Index endpoint: G6_AUTONOM – Autonomic disorders

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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