Idiopathic peripheral autonomic neuropathy

G6_IDIOAUT

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G90.0 Hospital discharge: ICD-9 — 3370 Cause of death: ICD-10 — G90.0 Cause of death: ICD-9 — 3370 2 out of 7 registries used, show all original rules.	156
4. Check minimum number of events None	156
5. Include endpoints None	156
6. Filter based on genotype QC (FinnGen only)	135

Control definitions (FinnGen only)

Control exclude: G6_AUTONOM

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: G90
Name in latin: Neuropathia autonomica peripherica idiopathica

NAME	G6_IDIOAUT
CONTROL_EXCLUDE	G6_AUTONOM
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G900
HD_ICD_9	3370
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G900
COD_ICD_9	3370
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Idiopathic peripheral autonomic neuropathy based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	941	432	497
Only index persons	774	372	402
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.02
Median age at first event (years)
Whole population	57.97	60.25	55.86
Only index persons	55.19	57.82	52.76

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	135	67	68
Unadjusted period prevalence (%)	0.03	0.02	0.03
Median age at first event (years)	61.32	56.40	66.17

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
140: Matched controls
1400

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G90.0

ICD-10 Finland

Idiopathic peripheral autonomic neuropathy

+∞

196.3

138

R55

ICD-10 Finland

Syncope and collapse

12.1

46.6

AA1AD

NOMESCO Finland

CT of head and brain

3.2

10.3

270

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

4.2

9.4

N03AX16

ATC

[U] pregabalin

3.2

8.9

192

XFP20

NOMESCO Finland

Check up of cardiac pacemaker

4.7

8.8

I49.5

ICD-10 Finland

Sick sinus syndrome

8.3

8.8

FPE20

NOMESCO Finland

Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes

8.3

8.8

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

4.5

8.2

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

5.0

7.9

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.7

7.4

476

Z45.0

ICD-10 Finland

Adjustment and management of cardiac devices

8.1

7.4

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

4.1

7.4

SPAT1229

SPAT

Assessment of need for aid

4.8

7.2

F32.9

ICD-10 Finland

Depressive episode, unspecified

3.6

7.0

XF404

NOMESCO Finland

Ambulatory ECG

3.9

6.6

FPK00

NOMESCO Finland

Implantation of electrocardiograph with loop recorder

28.1

6.3

G91.0

ICD-10 Finland

Communicating hydrocephalus

+∞

6.3

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

3.8

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3032080) INR in Blood by Coagulation assay

558

2.80

7.81

12.3

14.5

1.20

1.28

inr

0.78

470

(3023368) Bacteria identified in Blood by Culture

325

2.48

6.28

3.8

4.5

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

636

2.45

5.84

6.4

6.3

10.33

11.60

umol/l

1.25

607

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

620

2.41

5.71

7.8

7.3

1.21

mmol/l

0.18

526

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

319

2.33

5.38

2.8

2.2

3.08

2.77

mg/l

0.52

278

(3019309) Folate [Moles/volume] in Red Blood Cells

210

2.43

5.08

1.7

1.8

1125.82

1191.02

nmol/l

0.16

158

(3018418) pH of Serum or Plasma

385

2.22

5.01

3.7

4.2

7.40

7.39

0.20

265

(3004588) Protein electrophoresis panel - Serum or Plasma

3.04

4.97

2.7

2.4

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

474

2.19

4.93

4.5

4.3

19.41

39.18

ng/l

2.51

357

(3024561) Albumin [Mass/volume] in Serum or Plasma

545

2.09

4.37

5.1

4.7

35.38

35.46

g/l

0.04

517

(3037522) Nuclear Ab [Titer] in Serum

161

2.37

4.14

1.6

1.3

373.33

477.84

titre

—

(3007853) Bacteria identified in Skin by Aerobe culture

131

2.42

3.84

1.8

1.7

—

(3021960) Folate [Moles/volume] in Serum or Plasma

370

1.97

3.63

1.9

1.7

17.88

21.79

nmol/l

1.76

305

(3013512) EKG study

415

1.89

3.29

3.7

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

562

1.88

3.29

4.5

3.1

124.61

122.41

ug/l

0.02

525

(3001604) Monocytes [#/volume] in Blood

610

1.89

3.29

9.5

5.7

0.55

0.59

e9/l

0.71

525

(3006315) Basophils [#/volume] in Blood

610

1.89

3.29

9.5

5.7

0.04

e9/l

0.03

524

(3013115) Eosinophils [#/volume] in Blood

631

1.88

3.25

10.0

5.9

0.18

0.19

e9/l

0.26

545

(4035726) Immunohistochemistry procedure

106

2.40

3.25

1.2

1.3

—

(42529406) Shigella sp [Presence] in Stool by Culture

3.64

2.97

1.4

1.3

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

3.64

2.97

1.4

1.3

—

(40758558) Short blood count panel - Blood

374

1.83

2.93

8.1

6.0

—

(3019198) Lymphocytes [#/volume] in Blood

628

1.79

2.83

9.6

5.7

1.89

1.78

e9/l

0.42

555

(36304419) Bacteria [Presence] in Urine

343

1.82

2.81

3.5

3.0

—

estimate

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

268

1.87

2.77

2.8

2.2

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

4.85

2.63

1.3

1.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

200

1.92

2.60

2.1

1.9

—

(42870588) Differential panel, method unspecified - Blood

403

1.75

2.59

9.7

5.3

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

3.39

2.57

4.9

2.7

1.55

1.52

ratio

—

(21494890) Protein electrophoresis panel - 24 hour Urine

5.64

2.57

1.8

4.6

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.55

2.56

1.8

1.7

—

(40768797) Stomach Pathology biopsy report

155

2.01

2.53

1.2

1.3

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

202

1.90

2.52

3.0

0.94

1.20

e6/l

0.28

110

(3004616) Nuclear Ab [Presence] in Serum

4.54

2.51

1.7

1.1

—

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

3.28

2.49

1.8

1.7

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

416

1.72

2.48

2.9

3.3

2.34

2.36

mmol/l

0.58

385

(3033658) Prothrombin time (PT) actual/Normal

294

1.78

2.47

4.4

3.5

84.71

86.81

0.25

289

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

236

1.84

2.45

3.6

37.13

127.27

ng/l

1.16

184

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

4.28

2.39

1.3

1.6

—

(3045142) Bone marrow Pathology biopsy report

6.43

2.39

2.6

1.3

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

4.77

2.29

3.3

4.1

2.75

2.64

nmol/l

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

4.04

2.28

2.9

2.0

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

4.04

2.28

1.1

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.82

2.26

1.4

1.7

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

5.71

2.23

1.0

2.3

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

5.71

2.23

1.0

2.3

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

5.71

2.23

1.0

2.3

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

269

1.74

2.19

1.8

1.7

1.42

0.87

mg/l

0.82

219

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.19

2.11

2.1

1.7

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

3.03

2.11

1.2

1.3

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

5.14

2.09

1.2

1.1

—

(3035637) Corticotropin [Mass/volume] in Plasma

5.14

2.09

1.8

2.8

19.86

51.30

ng/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

120

1.99

2.07

4.2

3.5

—

(3044640) Blood type and Crossmatch panel - Blood

379

1.64

2.04

3.5

2.3

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.68

1.98

1.5

2.0

—

(3018095) Leukocytes [#/volume] in Urine

473

1.60

1.98

4.4

4.2

28.02

86.94

e6/l

1.41

347

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.84

1.97

1.6

2.1

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

4.67

1.96

1.2

1.1

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

4.67

1.96

1.4

1.2

—

(3032773) Endomysium IgG Ab [Titer] in Serum

4.67

1.96

1.0

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.33

1.91

1.1

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

3.29

1.90

1.3

1.8

—

(3044290) Cell count panel - Cerebral spinal fluid

3.29

1.90

1.1

—

(1761868) Lipid panel - Serum or Plasma

449

0.58

1.90

3.1

3.3

—

(3042936) Bacteria identified in Isolate by Culture

163

1.81

1.89

1.7

2.1

—

(3021589) Normoblasts [#/volume] in Blood

553

1.58

1.89

13.8

12.1

0.00

e9/l

0.32

451

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

772

1.61

1.88

4.5

3.2

55.17

46.30

u/l

0.43

729

(3018677) aPTT in Platelet poor plasma by Coagulation assay

188

1.76

1.86

2.6

1.9

28.42

28.92

0.25

182

(40761535) Cells panel - Urine sediment

2.07

1.78

8.8

4.3

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.25

1.78

1.3

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.60

1.77

1.4

1.3

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.12

1.77

1.1

1.2

—

(3007164) IgA [Mass/volume] in Serum or Plasma

277

1.62

1.72

1.9

1.3

1.74

2.46

g/l

2.96

154

(3021601) Nitrite [Presence] in Urine by Test strip

640

1.54

1.71

5.1

4.1

0.00

estimate

-0.00

142

(3035350) Ketones [Presence] in Urine by Test strip

650

1.54

1.71

5.0

4.1

0.00

estimate

-0.00

149

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

2.61

1.70

1.2

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.89

1.67

1.3

1.4

—

(3026782) Osmolality of Urine

254

1.62

1.64

2.7

3.2

536.58

522.04

mosm/kgh2o

0.15

225

(3002582) Erythrocytes [#/volume] in Urine

424

1.53

1.63

3.8

3.5

17.34

210.71

e6/l

0.72

337

(3013650) Neutrophils [#/volume] in Blood by Automated count

695

1.52

1.61

13.4

9.3

3.88

4.14

e9/l

0.50

594

(3030467) Casts [#/volume] in Urine by Automated count

353

1.55

1.59

3.9

3.3

0.32

0.36

e6/l

0.09

267

(3009261) Glucose [Presence] in Urine by Test strip

649

1.50

1.54

5.1

4.2

0.00

0.03

estimate

0.50

133

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

2.94

1.52

1.5

1.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

158

1.71

1.51

1.6

—

(3015736) pH of Urine

507

1.48

5.0

3.8

6.24

6.21

0.09

295

(1616796) Gas panel - Central venous blood

2.58

1.47

1.0

3.5

—

(3029937) Albumin [Presence] in Urine by Test strip

361

1.50

1.42

6.3

4.2

0.00

estimate

-0.00

131

(46235355) HIV 1 and 2 tests - Meaningful Use set

229

1.58

1.39

1.9

2.0

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

522

1.46

1.38

3.0

2.1

95.02

95.24

pmol/l

0.01

260

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

213

1.58

1.36

1.7

1.3

23.91

30.98

iu/ml

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

248

1.55

1.35

1.8

367.93

438.99

pmol/l

1.56

211

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.82

1.34

1.4

1.5

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

189

1.60

1.32

1.7

1.4

1.06

7.78

u/ml

1.61

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

189

1.60

1.32

3.1

3.3

9.00

2.50

e6/l

0.69

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

123

1129

1.74

1.31

24.8

16.6

22.46

24.99

mg/l

0.42

112

923

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

2.43

1.31

1.0

2.4

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.43

1.31

1.3

1.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

548

1.43

1.26

2.8

2.7

—

estimate

—

(40768804) Tissue Pathology biopsy report

434

1.44

1.25

2.4

2.1

—

(3011288) Drugs identified in Urine by Screen method Nominal

2.23

1.23

4.0

2.2

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.17

1.20

1.0

1.8

—

(3028707) Methadone [Presence] in Urine by Screen method

2.36

1.20

2.0

—

(3037756) Immunofixation for Serum or Plasma

2.36

1.20

2.0

1.3

—

(36660697) Celiac disease serology panel - Serum

104

1.72

1.15

1.5

1.1

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

1.15

0.0

4.5

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.40

1.14

1.7

1.2

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

394

1.42

1.13

3.0

3.4

611.35

1627.59

ng/l

3.69

337

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.73

1.12

1.5

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

197

1.53

1.11

1.7

—

(40768800) Prostate Pathology biopsy report

2.43

1.10

1.4

1.1

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

2.18

1.07

1.7

16.51

2.97

mg/l

—

(3022145) Colonoscopy Study observation

140

1.59

1.05

1.5

1.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

157

1.56

1.04

2.2

1.8

—

(3045716) Anion gap in Serum or Plasma by calculation

2.32

1.04

3.0

2.1

12.80

10.36

mmol/l

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

149

1.57

1.03

2.0

1.9

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

123

1145

1.61

1.03

27.4

19.7

4.00

3.97

mmol/l

0.40

123

1126

(3019550) Sodium [Moles/volume] in Serum or Plasma

123

1145

1.61

1.03

27.0

19.5

139.43

139.65

mmol/l

0.46

123

1128

(4024509) Urine culture

1.89

1.01

2.0

1.7

—

(40761511) CBC panel - Blood by Automated count

124

1158

1.62

1.01

20.6

15.4

—

(3026008) Bacteria identified in Urine by Culture

384

1.38

0.98

4.4

3.2

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

311

1.40

0.96

1.6

1.3

7.75

0.75

u/ml

0.45

(3000991) Gas panel - Venous blood

110

1.62

0.96

6.7

7.7

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

111

1.60

0.93

1.7

2.2

34.06

31.44

u/l

0.10

(3022313) Gas panel - Capillary blood

1.85

0.90

5.7

3.9

—

(40761536) Microorganisms panel - Urine sediment

1.59

0.82

3.8

3.6

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

248

1.38

0.78

3.1

2.7

2.48

2.45

mmol/l

0.55

226

(3014576) Chloride [Moles/volume] in Serum or Plasma

177

1.43

0.77

5.4

6.4

105.96

104.10

mmol/l

0.99

177

(3003327) Ova and parasites identified in Stool by Light microscopy

1.80

0.77

1.3

—

(3039443) Prostate specific Ag panel - Serum or Plasma

2.22

0.77

2.2

1.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

107

0.54

0.76

3.0

2.4

3.03

3.32

ratio

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.89

0.75

1.3

1.8

—

(3027801) Oxygen [Partial pressure] in Arterial blood

152

1.45

0.74

5.0

7.2

13.23

11.91

kpa

0.58

145

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

152

1.45

0.74

5.0

7.2

5.24

5.06

kpa

0.30

145

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.84

0.73

1.9

1.3

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.84

0.73

3.0

2.5

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

1.79

0.72

1.7

2.8

0.97

1.66

mg/l

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

136

1.46

0.71

13.5

8.5

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

1.96

0.71

1.2

1.3

—

(3019150) Specific gravity of Urine by Refractometry

299

1.32

0.70

6.6

4.2

1.02

kg/l

0.59

198

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.66

0.68

2.1

1.7

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

1.81

0.67

1.2

1.3

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

125

1191

1.46

0.65

16.0

11.7

24.75

25.42

u/l

0.21

125

1161

(3012544) pH of Venous blood

139

1.42

0.64

3.3

3.7

7.38

7.39

0.12

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

1.75

0.64

1.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.63

0.63

1.8

1.4

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

125

1193

1.45

0.62

29.5

21.3

79.97

79.64

umol/l

0.03

125

1180

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.69

0.62

1.6

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.61

0.0

2.6

—

1.18

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.61

0.0

3.7

—

52.40

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.60

0.0

1.3

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.60

0.0

2.5

—

4.06

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.60

0.0

2.5

—

108.05

—

(40768443) Skin Pathology biopsy report

1.70

0.57

1.5

1.3

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

108

1.44

0.56

1.3

1.6

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

1.56

0.53

1.7

2.0

278.83

338.65

mu/l

—

(3000494) Fungus identified in Specimen by Culture

136

1.37

0.52

1.1

1.4

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.52

0.52

1.2

1.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

503

1.22

0.52

5.4

4.1

0.00

0.02

estimate

0.50

126

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

103

1088

0.80

0.51

5.8

5.1

5.88

5.95

mmol/l

0.26

993

(3049717) Cytology report of Urine Cyto stain

1.58

0.50

3.3

3.0

—

(3016879) Cocaine [Presence] in Urine

1.51

0.48

2.1

1.7

—

(3025159) Blasts/Leukocytes in Blood

112

1.38

0.47

3.1

4.2

0.40

0.39

—

(3027008) Opiates [Presence] in Urine

1.45

0.46

2.1

1.7

—

(3028300) Cannabinoids [Presence] in Urine

1.45

0.46

2.1

1.7

—

(3027944) Amphetamines [Presence] in Urine

1.42

0.45

2.1

1.7

—

(3000764) Benzodiazepines [Presence] in Urine

1.42

0.45

2.1

1.7

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.41

0.0

1.4

—

(3019977) pH of Arterial blood

151

1.30

0.41

5.3

7.3

7.42

—

(21494755) Public health laboratory ask at order entry panel

103

0.66

0.41

1.1

1.5

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.40

0.0

1.6

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.40

0.0

1.4

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

101

956

1.20

0.40

29.2

20.7

13.87

13.65

0.85

101

948

(3025941) Bacteria identified in Stool by Culture

1.29

0.37

1.6

1.2

—

(42868678) Cholesterol non HDL [Moles/volume] in Serum or Plasma

0.62

0.36

2.2

2.3

3.20

3.38

mmol/l

—

(3017181) Myelocytes/Leukocytes in Blood

118

1.30

0.35

2.8

3.8

1.67

0.80

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

106

1099

0.85

0.29

6.3

5.9

2.67

2.62

mmol/l

0.22

100

1016

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

108

1041

1.16

0.27

7.0

6.4

38.53

39.76

mmol/mol

0.74

103

977

(3016502) Oxygen saturation in Arterial blood

133

1.23

0.25

5.4

7.7

95.54

95.76

0.05

128

(3002256) Pathology report gross observation

133

1.23

0.25

1.4

1.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

124

1.23

0.25

2.6

2.4

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

1.36

0.24

1.0

1.6

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

316

1.14

0.23

5.1

4.7

21.95

22.53

0.09

145

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.21

0.0

1.4

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3009595) Pneumocystis jirovecii DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.3

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.3

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.21

0.0

5.2

—

(3011648) Oxygen content in Venous blood

0.00

0.21

0.0

2.2

—

10.24

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.20

0.0

5.4

—

133.41

—

(3007461) Platelets [#/volume] in Blood

125

1226

1.18

0.19

38.1

24.7

237.63

243.73

e9/l

0.47

125

1207

(3041096) Erythrocytes [Presence] in Urine by Automated

381

1.11

0.17

2.9

3.6

0.00

0.02

estimate

0.50

116

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.17

0.17

3.3

2.6

0.56

0.68

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.17

0.17

3.3

2.7

1.89

1.03

—

(3026361) Erythrocytes [#/volume] in Blood

125

1228

1.17

0.16

38.1

24.7

4.34

4.47

e12/l

1.98

125

1203

(3000963) Hemoglobin [Mass/volume] in Blood

125

1228

1.17

0.16

38.3

24.9

129.49

134.32

g/l

3.18

125

1216

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

125

1228

1.17

0.16

38.5

25.0

39.08

40.21

2.37

125

1216

(3010813) Leukocytes [#/volume] in Blood

125

1228

1.17

0.16

38.2

24.8

6.71

6.64

e9/l

0.16

125

1202

(3024731) MCV [Entitic mean volume] in Red Blood Cells

125

1228

1.17

0.16

38.0

24.6

90.88

90.91

0.02

125

1217

(3035941) MCH [Entitic mass]

125

1228

1.17

0.16

37.9

24.6

30.23

30.25

0.05

125

1217

(3020682) Albumin/Creatinine [Ratio] in Urine

388

0.90

0.16

3.9

4.21

8.03

mg/mmol

1.01

248

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

244

0.88

0.16

4.0

3.0

0.82

0.93

ug/l

0.22

146

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

100

1026

0.91

0.15

4.5

4.4

1.31

1.26

mmol/l

0.28

940

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

105

1075

0.91

0.15

5.4

5.3

4.47

4.51

mmol/l

0.13

996

(3017446) Testosterone [Moles/volume] in Serum or Plasma

105

0.85

0.13

2.7

2.3

32.23

14.49

nmol/l

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

105

1072

0.92

0.12

5.3

5.1

1.40

1.44

mmol/l

0.33

984

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

126

0.86

0.12

1.5

1.6

—

(3003694) ABO and Rh group [Type] in Blood

329

0.93

0.10

1.5

1.4

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

1.12

0.10

2.0

1.6

—

519.75

u/l

—

(3008898) HLA-B27 [Presence]

1.12

0.10

1.0

1.1

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.07

0.09

1.4

1.7

—

7.62

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

721

1.06

0.08

3.2

—

(3014051) Protein [Presence] in Urine by Test strip

347

0.94

0.08

2.5

3.2

—

0.00

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

1.06

0.08

3.3

4.7

1.41

1.53

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.03

0.08

1.0

1.1

—

(3000492) Spirometry study

111

0.89

0.06

1.7

1.6

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

160

0.93

0.04

1.3

1.5

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

471

1.03

0.02

2.1

1.9

1.26

1.32

mmol/l

0.21

394

(3019832) Treponema pallidum Ab [Presence] in Serum

113

1.07

0.02

1.8

1.9

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

116

1.04

0.00

3.0

2.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

296

1.02

0.00

7.4

4.9

—

(3009508) Creatinine [Moles/volume] in Urine

422

0.99

0.00

3.3

3.1

8.41

7.78

mmol/l

0.25

356

(3012516) Albumin [Mass/volume] in Urine

387

1.01

0.00

3.3

3.2

32.83

53.70

mg/l

0.54

254

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

205

1.03

0.00

2.7

1.6

—

(3019060) Gas panel - Arterial blood

0.97

0.00

2.8

4.1

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.7

—

912.14

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.0

—

10.23

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

207.44

—

(3013727) Leukocytes other/Leukocytes in Blood

0.00

-0.00

0.0

4.6

—

63.80

—

(3022689) Creatine [Moles/volume] in Urine

0.00

-0.00

0.0

1.6

—

10.08

—

(3012741) Chlamydophila pneumoniae IgA Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

64.00

—

(3011544) Albumin [Mass/volume] in Pleural fluid

0.00

-0.00

0.0

1.0

—

18.60

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

-0.00

0.0

1.0

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

4.0

—

4.56

—

(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.9

—

4.71

—

(3004451) EKG impression Narrative

0.00

-0.00

0.0

1.3

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

-0.00

0.0

2.2

—

1.66

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

0.62

—

(3020485) Acetaminophen [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.1

—

(3036432) Mycobacterium tuberculosis genotype [Identifier] in Isolate

0.00

-0.00

0.0

11.2

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

1.02

-0.00

3.5

4.9

0.90

0.88

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

93.98

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

-0.00

0.0

1.0

—

(3019897) Erythrocyte [DistWidth] in Red Blood Cells by Automated count

0.00

-0.00

0.0

2.4

—

13.67

—

(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.2

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.0

—

4.61

—

(40758292) HTLV I+II Ab panel - Serum

0.00

-0.00

0.0

1.6

—

(44816893) Food Allergen Mix 50 (Kiwi+Pineapple+Banana+Mango) IgE Ab [Units/volume] in Serum by Multidisk

0.00

-0.00

0.0

1.0

—

0.28

—

(3002222) Hepatitis E virus IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

0.31

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.3

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

-0.00

0.0

1.0

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

-0.00

0.0

1.2

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

2.6

—

0.71

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_IDIOAUT and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_IDIOAUT	2.777 [2.01, 3.83]	< 0.001
Birth year	0.994 [0.98, 1.01]	0.307

During the follow-up period (1.1.1998 — 31.12.2019), 116 out of 349 females with G6_IDIOAUT died.

Males

Parameter	HR [95% CI]	p-value
G6_IDIOAUT	1.888 [1.43, 2.49]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.003

During the follow-up period (1.1.1998 — 31.12.2019), 150 out of 429 males with G6_IDIOAUT died.

Mortality risk

Mortality risk for people of age

years, who have G6_IDIOAUT.

N-year risk	Females	Males
1	0.284%	0.399%
5	1.651%	2.298%
10	4.088%	5.4%
15	7.869%	10.144%
20	13.603%	17.063%

Relationships between endpoints

↥

Index endpoint: G6_IDIOAUT – Idiopathic peripheral autonomic neuropathy

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Idiopathic peripheral autonomic neuropathy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints