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Horner syndrome

DOID EFO Endpoint Browser PheWeb

G6_HORNER

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G90.2
  • Hospital discharge: ICD-8 — 35800
  • Cause of death: ICD-10 — G90.2
  • Cause of death: ICD-8 — 35800

2 out of 7 registries used, show all original rules.

497

4. Check minimum number of events

None

497

5. Include endpoints

None

497

6. Filter based on genotype QC (FinnGen only)

455

Control definitions (FinnGen only)

Control exclude
G6_AUTONOM

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G90
Name in latin
Syndroma Horner

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2743 1372 1366
Only index persons 2515 1258 1257
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.04
Only index persons 0.05 0.05 0.05
Median age at first event (years)
Whole population 52.54 54.09 50.94
Only index persons 52.78 54.46 51.10

-FinnGen-

Key figures

All Female Male
Number of individuals 455 256 199
Unadjusted period prevalence (%) 0.09 0.09 0.09
Median age at first event (years) 55.94 56.31 55.46

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
469
Matched controls
4690
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G90.2
ICD-10 Finland
Horner syndrome
+∞
307.7
461
*
H02.4
ICD-10 Finland
Ptosis of eyelid
15.3
90.4
85
67
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
10.8
56.4
65
69
H57.0
ICD-10 Finland
Anomalies of pupillary function
58.9
37.1
43
8
AA1AD
NOMESCO Finland
CT of head and brain
3.2
33.8
209
930
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
9.7
29.8
36
40
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.3
29.5
86
231
I67.0
ICD-10 Finland
Dissection of cerebral arteries, nonruptured
148.5
26.9
28
*
XCK00
NOMESCO Finland
Perimetry
4.7
22.2
55
129
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
9.4
21.4
26
29
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
20.8
276
1701
G44.0
ICD-10 Finland
Cluster headache syndrome
19.4
20.7
31
17
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
6.1
19.1
34
59
PA6CG
NOMESCO Finland
Extensive MRI examination of neck vasculature with high intensity magnet
73.0
18.9
21
*
XCK10
NOMESCO Finland
Photography of fundus of eye
3.1
15.2
69
245
B01AA03
ATC
warfarin; systemic
2.6
15.2
105
468
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.1
15.1
72
263
PA6AD
NOMESCO Finland
CT of neck arteries
4.3
14.8
40
100
CBJ40
NOMESCO Finland
Resection of levator muscle of eyelid
16.1
14.5
23
15
N03AX16
ATC
[U] pregabalin
2.3
14.2
137
708
PA6BG
NOMESCO Finland
MRI examination of neck vasculature with high intensity magnet
43.9
14.2
17
*
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
5.4
13.1
26
50
CBJ41
NOMESCO Finland
Shortening of superior tarsal muscle (Müller's muscle)
51.5
12.9
15
*
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
4.3
12.3
33
82
R51.80
ICD-10 Finland
Headache
2.2
10.4
99
503
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
3.0
10.2
48
174
WX002
NOMESCO Finland
Sedation and analgesia
2.2
10.1
105
552
XLA10, ,
NOMESCO Finland
4.2
10.1
27
67
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
3.5
9.8
35
107
I63.2
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
13.8
9.7
16
12
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
5.5
9.7
19
36
N02AX02
ATC
tramadol; systemic, rectal
1.9
9.7
222
1530
35800
ICD-8 Finland
Disease of peripheral autonomic nervous system, Syndroma Horner
+∞
9.4
9
*
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.2
9.4
39
131
R42
ICD-10 Finland
Dizziness and giddiness
2.0
9.3
122
699
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.5
9.2
62
270
TAB00
NOMESCO Finland
Lumbar puncture
3.1
9.1
38
128
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
8.7
103
566
WX110
NOMESCO Finland
Infiltration anesthesia
1.9
8.6
347
2806
C08DA01
ATC
verapamil; systemic
3.3
8.5
33
106
PA7BD
NOMESCO Finland
CT angiography of neck and brain
7.4
8.0
18
25
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.7
8.0
44
173
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
15.3
7.7
12
8
N06AX21
ATC
duloxetine; oral
2.2
7.7
68
333
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.8
7.6
38
142
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
10.3
7.6
14
14
Q13.2
ICD-10 Finland
Other congenital malformations of iris
30.5
7.2
9
*
EP1BG
NOMESCO Finland
MRI examination of soft tissue of neck with high intesity magnet
20.4
7.2
10
5
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
7.0
125
784
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
2.1
6.9
69
354
WX402
NOMESCO Finland
General anaesthesia
1.8
6.7
115
710
H02AB06
ATC
prednisolone; systemic
1.7
6.7
225
1677
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.2
6.6
61
304
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.7
6.5
35
136
H53.1
ICD-10 Finland
Subjective visual disturbances
2.5
6.5
42
179
A02BC05
ATC
esomeprazole; systemic
1.7
6.5
197
1425
C10AA05
ATC
atorvastatin; oral
1.7
6.5
201
1462
CBJ30
NOMESCO Finland
Plastic repair of levator aponeurosis of eyelid
14.6
6.4
10
7
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
11.2
6.3
11
10
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
6.3
168
1174
TDM10
NOMESCO Finland
Puncture of maxillary antrum
3.2
6.3
24
77
I72.0
ICD-10 Finland
Aneurysm and dissection of carotid artery
27.1
6.2
8
*
A03FA01
ATC
metoclopramide; systemic, rectal
1.8
6.2
114
719
R51
ICD-10 Finland
Headache
2.7
6.1
32
123
A02BC02
ATC
pantoprazole; systemic
1.7
6.1
323
2671
H57.1
ICD-10 Finland
Ocular pain
3.0
6.0
27
95
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
6.0
141
950

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
332
2461
2.19
13.33
6.6
5.3
6.49
6.70
mmol/l
1.16
320
2339
274
1911
2.04
12.66
12.6
13.3
1.23
1.22
inr
0.09
228
1572
207
1314
2.03
12.37
2.4
2.1
174.47
264.19
u/l
0.86
198
1252
267
1894
1.95
11.21
8.5
6.8
1.21
1.21
mmol/l
0.50
249
1754
287
2093
1.96
11.02
9.8
7.5
1.22
1.21
mmol/l
0.25
242
1822
213
1411
1.93
10.87
7.2
6.1
—
—
—
0
0
167
1048
1.92
9.80
5.3
4.1
90.25
90.53
%
0.05
167
1030
254
1827
1.85
9.67
6.2
5.1
35.71
35.91
g/l
0.24
236
1718
274
2036
1.83
9.21
7.6
6.4
26.33
27.80
%
1.50
263
1940
293
2234
1.83
8.92
7.3
6.6
0.19
0.20
e9/l
0.21
263
1955
380
3161
2.07
8.74
11.2
8.5
83.60
78.86
u/l
0.84
367
3004
268
1998
1.80
8.71
7.6
6.3
2.87
2.92
%
0.15
253
1879
268
1998
1.80
8.71
7.7
6.4
9.05
8.85
%
0.61
255
1888
308
2397
1.83
8.63
10.5
9.9
4.41
4.03
e9/l
1.67
271
2098
267
1995
1.79
8.55
7.7
6.4
0.70
0.71
%
0.10
254
1873
288
2206
1.79
8.41
7.2
6.3
1.79
1.94
e9/l
1.54
258
1951
283
2168
1.77
8.15
7.2
6.3
0.04
0.04
e9/l
0.15
247
1863
282
2159
1.77
8.13
7.3
6.3
0.61
0.58
e9/l
1.08
245
1856
267
2017
1.75
8.02
7.6
6.3
58.33
57.18
%
0.91
257
1930
190
1305
1.77
7.97
5.2
4.1
7.40
7.40
ph
1.45
145
922
442
4000
2.82
6.88
23.3
15.9
24.73
23.38
mg/l
0.30
391
3291
85
484
1.92
6.39
8.8
9.6
1.07
0.92
mmol/l
0.12
72
416
31
116
2.79
6.21
2.2
1.8
7.97
5.42
iu/l
0.33
12
48
188
1356
1.64
6.21
3.7
3.3
23.13
110.60
e6/l
1.09
138
1039
419
3742
2.12
6.09
7.2
5.3
1.84
1.89
mu/l
0.43
396
3459
126
825
1.72
5.97
4.8
4.0
84.07
374.72
ng/l
2.41
99
635
209
1560
1.61
5.94
4.4
3.9
55.54
89.57
e6/l
0.53
140
1092
149
1023
1.67
5.91
2.6
2.4
—
—
—
0
0
445
4085
2.75
5.88
26.3
18.7
139.71
139.70
mmol/l
0.03
440
4008
166
1174
1.64
5.85
3.6
3.1
0.42
0.41
e6/l
0.02
118
856
280
2248
1.61
5.83
8.3
6.8
11.67
11.34
umol/l
0.20
270
2149
445
4091
2.71
5.75
26.5
18.8
3.96
3.97
mmol/l
0.71
439
4004
334
2805
1.66
5.75
5.3
4.6
—
2.94
—
0
7
84
494
1.85
5.70
8.8
9.5
7.41
7.42
ph
0.19
40
276
66
360
1.97
5.61
11.1
9.4
—
—
—
0
0
163
1159
1.62
5.57
4.8
4.4
—
—
—
0
0
194
1439
1.59
5.56
3.8
3.5
2.35
2.36
mmol/l
0.60
181
1315
174
1262
1.60
5.46
2.7
3.1
939.90
1178.30
ng/l
0.64
148
1073
246
1945
1.56
5.25
3.1
2.8
—
—
estimate
—
0
0
236
1850
1.55
5.22
2.6
2.5
77.57
76.81
nmol/l
0.17
217
1670
173
1268
1.58
5.13
7.0
6.1
—
—
—
0
0
102
663
1.69
4.88
2.7
2.3
2.39
2.31
g/l
0.74
96
615
362
3155
1.65
4.85
5.9
4.3
14.97
14.78
pmol/l
0.73
340
2896
48
247
2.05
4.79
10.2
11.8
16.55
15.78
%
1.06
48
239
95
617
1.68
4.54
2.7
2.3
21.21
23.48
%
0.97
90
583
101
668
1.65
4.50
3.2
3.0
3.48
2.20
e6/l
0.32
48
317
207
1614
1.51
4.48
4.0
3.7
26.61
35.45
ng/l
0.90
150
1171
80
500
1.72
4.39
2.0
1.7
—
—
—
0
0
69
415
1.78
4.33
3.2
2.6
31.33
35.48
u/l
0.47
63
340
25
102
2.53
4.29
1.5
1.2
14.60
12.58
e6/l
0.05
20
76
188
1460
1.48
4.04
4.1
3.4
42.39
32.64
u/l
1.02
181
1379
270
2255
1.47
3.96
4.1
3.8
0.00
0.68
estimate
0.50
51
438
128
923
1.53
3.91
3.0
2.7
5.98
5.10
e6/l
0.41
111
842
204
1622
1.46
3.84
2.3
2.1
—
—
—
0
0
176
1362
1.47
3.80
2.8
2.4
—
—
—
0
0
439
4109
2.07
3.76
19.2
14.0
—
—
—
0
0
264
2211
1.44
3.72
4.0
3.8
0.00
0.00
estimate
-0.00
53
464
113
802
1.54
3.70
2.9
2.9
554.04
533.72
mosm/kgh2o
0.40
95
701
92
623
1.59
3.69
1.4
1.4
254.74
464.11
titre
2.63
19
141
224
1822
1.44
3.69
2.4
2.1
97.76
96.59
pmol/l
0.15
119
938
221
1796
1.44
3.64
3.6
3.3
6.17
6.17
ph
0.01
109
1038
174
1356
1.45
3.58
3.1
2.7
51.55
65.01
u/l
1.83
163
1265
68
431
1.68
3.54
3.8
4.5
3.05
17.54
ug/l
0.84
55
353
22
93
2.43
3.54
1.5
1.2
—
—
—
0
0
265
2234
1.43
3.52
4.1
3.8
0.00
3.98
estimate
0.50
53
472
145
1099
1.46
3.42
3.1
2.7
338.32
344.24
umol/l
0.28
124
965
183
1451
1.43
3.39
3.7
3.5
—
0.67
—
0
6
228
1880
1.41
3.39
13.2
11.4
0.00
0.00
e9/l
0.08
183
1544
11
28
4.00
3.30
1.2
1.1
0.58
0.50
ratio
—
5
15
124
922
1.47
3.21
1.8
1.7
2.73
1.30
mg/l
0.45
94
737
140
1069
1.44
3.14
2.5
2.1
2.73
2.90
mg/l
0.34
121
935
19
80
2.43
3.10
2.7
2.6
2.30
2.73
mmol/l
0.27
12
54
94
665
1.52
3.09
1.8
1.7
1124.61
1193.74
nmol/l
0.37
78
509
85
589
1.54
3.07
1.3
1.3
—
—
—
0
0
157
1232
1.41
3.02
1.9
1.7
20.26
20.80
nmol/l
0.17
135
1052
46
274
1.75
3.01
4.2
3.5
7.41
7.42
ph
0.56
40
222
318
2810
1.41
2.99
4.5
3.5
43.77
50.51
u/l
1.54
298
2665
55
345
1.67
2.99
1.6
1.5
—
—
—
0
0
233
1956
1.38
2.99
3.4
3.0
120.12
125.64
ug/l
0.19
217
1838
5
5
10.09
2.98
1.2
1.0
—
—
—
0
0
39
222
1.83
2.96
1.3
1.3
—
—
—
0
0
34
188
1.87
2.83
4.6
3.8
—
—
—
0
0
417
3898
1.63
2.82
5.7
5.1
5.89
5.96
mmol/l
0.46
387
3613
110
818
1.45
2.82
3.4
2.7
2.46
2.45
mmol/l
0.14
101
739
64
424
1.59
2.81
1.7
1.5
—
—
—
0
0
46
281
1.71
2.76
4.2
3.5
5.29
5.17
kpa
0.41
46
273
411
3835
1.58
2.73
7.0
6.4
39.44
39.31
mmol/mol
0.10
389
3616
62
411
1.59
2.72
2.7
2.6
0.23
0.22
g/l
1.00
56
384
78
547
1.51
2.67
1.7
1.4
—
—
—
0
0
154
1231
1.37
2.59
3.5
3.1
—
—
—
0
0
29
158
1.89
2.54
1.3
1.3
—
—
—
0
0
40
241
1.72
2.54
3.5
6.8
—
—
—
0
0
58
387
1.57
2.48
2.3
2.1
0.40
0.04
estimate
—
10
84
54
355
1.59
2.46
6.1
4.2
7.35
7.34
ph
0.08
36
257
62
425
1.53
2.36
3.8
3.4
1.09
1.84
mmol/l
0.97
57
365
12
47
2.59
2.28
1.1
1.3
—
—
—
0
0
108
831
1.39
2.26
1.4
1.3
17.49
36.16
iu/ml
2.43
32
250
7
18
3.93
2.26
2.3
3.2
697.43
699.56
u/ml
—
7
18
22
114
1.98
2.24
2.3
3.0
1.50
1.76
index
0.13
16
66
427
4053
1.60
2.23
6.4
5.9
2.66
2.71
mmol/l
0.59
396
3779
84
621
1.43
2.21
2.6
2.1
—
—
—
0
0
35
212
1.70
2.20
2.3
2.1
0.75
0.01
estimate
—
8
70
98
747
1.39
2.17
1.4
1.3
3.33
10.48
u/ml
1.99
24
296
10
36
2.82
2.15
3.5
1.9
46.00
38.56
%
—
10
36
13
55
2.40
2.14
1.1
1.0
0.20
3.51
u/ml
—
6
21
12
49
2.49
2.12
1.4
1.2
—
—
—
0
0
12
49
2.49
2.12
1.2
1.3
22.67
33.46
ng/l
0.67
12
49
451
4351
1.95
2.11
34.0
24.1
4.48
4.51
e12/l
0.51
446
4258
11
43
2.59
2.09
1.7
1.1
—
—
—
0
0
20
103
1.98
2.08
1.4
1.2
—
—
—
0
0
442
4241
1.73
2.08
16.7
12.3
27.89
26.67
u/l
0.48
435
4129
5
10
5.04
2.07
6.4
3.1
—
—
—
0
0
5
10
5.04
2.07
1.2
1.2
—
—
—
0
0
207
1774
1.30
2.07
1.9
2.0
1.35
1.36
mmol/l
0.01
165
1501
26
147
1.81
2.07
4.7
4.0
25.26
25.17
mmol/l
0.08
26
138
6
15
4.04
2.04
1.0
1.1
96.83
63.93
nmol/24h
—
6
15
421
3998
1.52
2.02
5.7
5.2
4.60
4.64
mmol/l
0.26
393
3741
44
291
1.57
1.99
1.4
1.3
90.83
328.81
u/ml
1.66
39
268
106
831
1.36
1.97
1.9
1.8
451.08
16549243.49
pmol/l
0.50
89
707
5
11
4.58
1.94
1.2
1.0
—
—
—
0
0
62
444
1.46
1.94
3.8
3.4
5.69
5.79
kpa
0.35
62
431
43
285
1.56
1.93
1.3
1.2
156.42
140.57
u/ml
0.06
19
120
13
58
2.28
1.92
1.1
1.0
3.41
5.78
u/ml
—
7
28
62
447
1.45
1.87
3.8
3.5
7.38
7.38
ph
0.39
35
252
364
3386
1.34
1.85
26.8
19.8
13.64
13.62
%
0.13
364
3356
68
505
1.41
1.76
4.4
3.0
8.55
7.32
umol/l
0.25
59
455
9
36
2.53
1.75
1.1
1.2
—
—
—
0
0
7
24
2.94
1.73
1.1
1.1
—
—
—
0
0
5
13
3.87
1.72
3.4
4.0
—
—
—
0
0
317
2914
1.27
1.65
4.9
4.1
—
0.25
—
0
8
21
121
1.77
1.61
1.7
2.3
10.37
11.66
mg/l
0.27
21
114
28
176
1.63
1.58
1.3
1.2
—
—
—
0
0
6
20
3.03
1.58
1.2
1.3
—
—
—
0
0
12
57
2.13
1.56
3.2
3.0
—
—
—
0
0
7
27
2.62
1.52
1.6
2.6
0.43
0.96
index
—
7
27
154
1318
1.25
1.46
4.7
5.1
1.93
2.34
ug/l
0.66
140
1197
5
16
3.15
1.44
3.4
3.4
—
—
—
0
0
71
550
1.34
1.44
2.6
2.4
77.51
128.80
ug/g
2.18
56
442
9
39
2.33
1.43
1.2
1.2
121.44
105.05
pmol/l
—
9
39
52
383
1.40
1.43
3.2
2.7
4.68
4.44
kpa
0.21
52
370
400
3813
1.33
1.41
4.8
4.4
1.31
1.30
mmol/l
0.11
369
3526
9
41
2.22
1.37
1.2
1.3
—
—
—
0
0
49
360
1.40
1.37
1.5
1.4
—
—
—
0
0
64
493
1.35
1.35
1.3
1.4
—
—
—
0
0
10
47
2.15
1.34
1.8
1.3
—
—
—
0
0
415
3984
1.36
1.34
5.8
5.1
1.48
1.46
mmol/l
0.35
387
3709
15
83
1.83
1.33
5.5
12.3
104.73
105.32
mmol/l
0.13
15
76
15
83
1.83
1.33
5.5
12.3
12.73
10.84
mmol/l
0.37
15
76
9
43
2.11
1.31
2.0
1.4
—
—
—
0
0
8
34
2.38
1.29
1.4
1.4
—
—
—
0
0
44
321
1.41
1.29
1.8
2.3
5.13
8.28
ug/l
0.68
34
296
66
515
1.33
1.28
1.9
1.7
—
—
—
0
0
9
44
2.07
1.27
2.4
2.6
—
22.78
—
0
6
9
44
2.07
1.27
3.3
1.8
9.27
11.42
%
—
9
44
12
63
1.93
1.24
3.3
3.2
3.94
4.67
e9/l
0.69
12
63
12
63
1.93
1.24
4.1
2.5
—
—
—
0
0
80
645
1.29
1.23
1.9
1.7
—
—
—
0
0
34
239
1.46
1.22
3.1
2.4
0.58
0.62
%
0.51
34
239
5
19
2.65
1.22
1.0
1.1
161.68
145.26
nmol/l
—
5
19
39
282
1.42
1.21
3.3
3.2
127.03
129.18
g/l
0.23
39
274
13
71
1.85
1.20
1.2
1.1
0.28
2.41
u/ml
—
8
40
19
118
1.64
1.16
5.1
10.2
1.12
1.24
mmol/l
0.55
19
105
93
772
1.26
1.14
2.2
2.0
—
—
—
0
0
8
40
2.02
1.12
1.8
1.0
—
—
—
0
0
7
31
2.28
1.10
1.0
1.3
—
—
—
0
0
7
31
2.28
1.10
1.3
1.4
—
—
—
0
0
19
120
1.61
1.10
1.4
1.3
8.17
8.87
u/l
—
10
95
11
59
1.89
1.08
1.2
1.1
—
—
—
0
0
19
122
1.58
1.04
1.1
1.1
—
—
—
0
0
5
22
2.29
1.03
1.0
1.0
1596.60
1522.36
miu/ml
—
5
22
22
320
0.67
1.02
1.7
1.8
3.04
3.49
mmol/l
1.01
15
234
20
131
1.55
1.01
1.2
1.5
175.14
281.78
miu/ml
—
7
59
7
35
2.01
1.00
2.1
2.7
—
—
—
0
0
7
35
2.01
1.00
1.3
1.2
413.57
375.55
nmol/l
—
7
29
43
329
1.34
0.98
3.8
3.8
—
—
—
0
0
7
36
1.96
0.97
1.0
1.1
—
—
—
0
0
33
243
1.39
0.96
3.2
2.5
1.08
1.26
%
0.76
33
243
14
85
1.67
0.95
3.4
2.8
—
—
—
0
0
7
37
1.91
0.94
1.7
1.9
—
—
—
0
0
55
440
1.28
0.93
1.7
1.6
—
—
—
0
0
117
1019
1.20
0.91
1.4
1.3
6.04
1.75
u/ml
0.39
25
304
28
203
1.40
0.89
1.8
2.0
28.94
5.83
iu/ml
—
8
54
22
153
1.46
0.87
1.3
1.5
—
—
—
0
0
8
44
1.83
0.86
3.8
3.3
4.42
3.17
nmol/l
—
8
44
8
44
1.83
0.86
1.5
3.7
—
—
—
0
0
20
137
1.48
0.85
1.5
1.3
—
—
—
0
0
28
205
1.39
0.85
1.9
1.5
0.29
0.33
mg/l
0.12
17
92
22
154
1.45
0.85
1.3
1.4
—
—
—
0
0
22
155
1.44
0.82
1.3
1.4
—
—
—
0
0
44
349
1.29
0.81
1.2
1.2
—
—
—
0
0
22
156
1.43
0.80
1.3
1.5
—
—
—
0
0
19
131
1.47
0.79
1.1
1.4
445.13
273.70
ug/g
—
8
75
6
34
1.77
0.76
1.3
1.5
160.32
164.76
pmol/l
—
6
34
9
53
1.71
0.76
1.9
1.4
0.61
0.54
nmol/l
—
9
48
92
801
1.18
0.73
2.8
3.0
0.72
0.77
ug/l
0.27
55
505
20
143
1.42
0.71
1.3
1.5
—
—
—
0
0
5
26
1.93
0.71
1.0
1.8
—
—
—
0
0
39
312
1.27
0.69
1.1
1.3
—
—
—
0
0
63
534
1.21
0.67
1.5
1.3
—
—
—
0
0
150
1636
0.88
0.64
3.5
3.2
—
—
—
0
0
15
104
1.46
0.63
1.9
1.9
—
—
—
0
0
18
130
1.40
0.62
1.7
2.3
2070.94
4808.32
u/l
—
8
44
17
122
1.41
0.61
1.2
1.2
—
—
—
0
0
8
52
1.55
0.59
1.1
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
1.8
—
—
—
0
0
37
301
1.25
0.59
2.1
1.6
1.17
1.36
g/l
0.40
32
277
13
89
1.47
0.58
3.5
2.9
59.54
59.41
%
0.02
13
89
20
150
1.35
0.56
3.1
2.8
—
—
—
0
0
6
38
1.59
0.54
1.0
1.4
0.51
1.22
promille
—
6
30
13
91
1.44
0.53
2.9
2.2
—
—
—
0
0
133
1220
1.13
0.53
4.4
3.8
0.00
0.00
estimate
-0.00
49
433
25
197
1.28
0.52
2.2
1.9
—
—
—
0
0
6
41
1.47
0.50
1.3
1.1
—
—
—
0
0
20
154
1.31
0.49
1.6
1.6
20.81
9.81
u/ml
—
7
24
148
1379
1.11
0.45
3.6
3.4
49.09
47.63
mg/l
0.03
93
878
16
121
1.33
0.44
1.3
1.5
—
—
—
0
0
10
69
1.46
0.44
4.8
3.5
0.71
0.75
nmol/l
—
10
57
130
1204
1.11
0.44
1.4
1.4
—
—
—
0
0
151
1410
1.10
0.44
4.3
4.1
7.28
7.95
mg/mmol
0.08
92
861
12
87
1.39
0.42
2.9
1.4
—
—
—
0
0
19
238
0.79
0.41
6.5
2.9
24.37
45.42
u/ml
0.83
19
229
0
16
0.00
0.41
0.0
1.2
—
37.94
—
0
10
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
23
186
1.25
0.41
1.3
1.8
—
—
—
0
0
22
177
1.25
0.41
6.1
7.5
0.93
0.90
%
0.16
22
166
10
138
0.72
0.41
11.5
10.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.5
—
—
—
0
0
9
66
1.37
0.38
1.1
1.2
—
—
—
0
0
24
197
1.23
0.38
2.8
3.4
24.72
25.07
mmol/l
0.17
24
189
16
125
1.29
0.37
1.1
1.2
—
—
—
0
0
9
69
1.31
0.37
1.0
1.1
—
10.27
—
0
16
40
348
1.16
0.36
2.6
2.4
0.87
0.51
e6/l
0.26
40
328
42
367
1.16
0.36
2.5
2.4
15.31
13.89
nmol/l
0.52
37
345
11
82
1.35
0.34
3.6
4.0
34.91
26.47
u/ml
0.22
11
82
156
1476
1.09
0.34
3.4
3.3
7.94
7.78
mmol/l
0.14
122
1251
6
45
1.34
0.34
1.3
1.2
—
—
—
0
0
42
370
1.15
0.33
3.5
4.7
0.09
0.14
%
0.21
11
99
104
969
1.09
0.32
4.6
4.9
—
—
—
0
0
35
306
1.16
0.31
4.0
3.1
—
—
—
0
0
10
75
1.34
0.30
1.3
1.5
—
—
—
0
0
10
75
1.34
0.30
1.3
1.5
—
—
—
0
0
10
75
1.34
0.30
1.3
1.5
—
—
—
0
0
10
75
1.34
0.30
1.3
1.5
—
—
—
0
0
97
904
1.09
0.30
1.7
1.4
2.23
2.57
g/l
1.09
57
551
24
281
0.85
0.29
1.6
2.6
—
—
—
0
0
106
993
1.09
0.29
4.2
3.8
1.02
1.02
kg/l
0.14
73
673
129
1221
1.08
0.28
3.1
3.3
0.00
0.08
estimate
0.63
44
376
24
205
1.18
0.28
1.0
1.1
—
95.17
—
0
6
43
385
1.13
0.28
1.5
1.4
—
—
—
0
0
9
116
0.77
0.27
1.8
1.4
—
—
—
0
0
8
66
1.22
0.27
1.0
1.3
—
—
—
0
0
11
86
1.29
0.26
1.2
1.1
—
—
—
0
0
11
86
1.29
0.26
1.2
1.1
—
—
—
0
0
42
378
1.12
0.25
3.5
5.1
0.00
0.18
%
—
10
88
41
370
1.12
0.24
3.3
4.6
0.42
0.56
%
0.28
12
107
6
84
0.71
0.24
1.3
1.6
—
—
—
0
0
14
115
1.22
0.23
2.0
1.8
242.86
232.87
pmol/l
0.10
14
108
18
153
1.18
0.22
1.5
1.5
0.23
0.23
g/l
0.11
18
146
25
221
1.14
0.20
1.2
1.1
—
—
—
0
0
23
202
1.15
0.20
5.9
6.9
1.55
1.56
%
0.02
23
191
13
108
1.21
0.20
1.6
2.3
65.69
65.59
ug/min
—
8
57
15
176
0.85
0.20
1.0
1.1
—
—
—
0
0
12
144
0.83
0.20
1.8
4.0
24.73
45.35
mg/l
0.80
12
122
12
144
0.83
0.20
1.8
4.0
28.92
79.00
mg/l
0.63
12
121
43
395
1.10
0.19
3.5
4.6
0.75
0.96
%
0.38
12
126
26
232
1.13
0.19
1.1
1.1
—
—
—
0
0
21
185
1.14
0.18
1.5
1.3
18.33
25.28
iu/l
0.59
15
155
173
1680
1.05
0.17
4.1
3.7
0.00
0.02
estimate
1.22
42
396
18
158
1.14
0.16
1.6
1.5
1.24
1.18
g/l
0.42
18
152
16
139
1.16
0.16
1.0
1.2
0.81
0.89
g/l
0.52
16
139
9
83
1.09
0.14
1.3
1.1
—
—
—
0
0
7
87
0.80
0.14
1.4
2.5
4.97
8.38
pmol/l
—
7
87
7
90
0.77
0.14
1.0
1.7
—
—
—
0
0
9
109
0.82
0.13
3.9
4.6
—
—
—
0
0
16
143
1.12
0.11
2.6
3.7
384.33
253.43
mg/l
—
6
61
6
57
1.05
0.08
1.3
2.6
107.67
105.93
mmol/l
—
6
57
6
57
1.05
0.08
1.3
2.6
1.19
1.19
mmol/l
—
6
57
6
57
1.05
0.08
1.3
2.6
3.98
4.00
mmol/l
—
6
57
7
67
1.05
0.08
1.0
1.1
—
—
—
0
0
14
127
1.11
0.08
1.0
1.1
—
0.63
—
0
16
6
71
0.84
0.07
1.2
1.5
—
—
—
0
0
6
73
0.82
0.07
1.2
1.5
—
—
—
0
0
8
74
1.08
0.07
1.1
1.2
—
—
—
0
0
8
78
1.03
0.07
1.1
1.2
29.28
18.96
u/l
—
8
67
58
562
1.04
0.06
4.5
3.2
3.97
5.28
e9/l
1.03
47
500
39
380
1.03
0.03
3.0
2.7
68.32
71.83
e9/l
0.24
26
277
43
420
1.03
0.02
1.7
1.5
—
—
—
0
0
34
332
1.03
0.02
3.1
2.5
6.05
6.12
ph
0.26
22
227
39
382
1.02
0.01
1.7
1.8
—
—
—
0
0
14
133
1.05
0.01
1.0
1.2
1.47
1.52
g/l
0.37
14
133
10
94
1.07
0.01
1.2
1.1
—
—
—
0
0
19
195
0.97
0.00
3.5
2.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
60.29
—
0
7
0
7
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.3
—
259.78
—
0
9
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
59
0.85
-0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
0.20
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
6.3
—
6.66
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
11.20
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.8
—
1.18
—
0
9
7
73
0.96
-0.00
1.4
1.6
—
—
—
0
0
7
71
0.99
-0.00
1.4
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
40.80
—
0
5
5
59
0.85
-0.00
1.8
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
54
0.93
-0.00
1.8
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.5
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint G6_HORNER and mortality.

Females

Parameter HR [95% CI] p-value
G6_HORNER 1.65 [1.36, 2.0] < 0.001
Birth year 0.998 [0.99, 1.01] 0.712

During the follow-up period (1.1.1998 — 31.12.2019), 199 out of 1204 females with G6_HORNER died.

Males

Parameter HR [95% CI] p-value
G6_HORNER 1.362 [1.12, 1.65] 0.002
Birth year 0.988 [0.98, 1.0] 0.016

During the follow-up period (1.1.1998 — 31.12.2019), 172 out of 1188 males with G6_HORNER died.

Mortality risk

Mortality risk for people of age

years, who have G6_HORNER.

N-year risk Females Males
1 0.154% 0.27%
5 0.995% 1.74%
10 2.61% 4.415%
15 5.056% 8.223%
20 9.002% 13.224%

Relationships between endpoints

↥

Index endpoint: G6_HORNER – Horner syndrome

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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