Other and unspecified disorders of autonomic nervous system

G6_AUTOTHUNS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G90.8, G90.9
  • Hospital discharge: ICD-9 337[1-9]
  • Cause of death: ICD-10 G90.8, G90.9
  • Cause of death: ICD-9 337[1-9]

2 out of 7 registries used, show all original rules.

177

4. Check minimum number of events

None

177

5. Include endpoints

None

177

6. Filter based on genotype QC (FinnGen only)

158

Control definitions (FinnGen only)

Control exclude
G6_AUTONOM

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1130 550 569
Only index persons 923 477 446
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 50.73 48.91 52.18
Only index persons 48.28 47.06 49.57

-FinnGen-

Key figures

All Female Male
Number of individuals 158 96 62
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 49.52 46.35 54.42

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
164
Matched controls
1640
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G90.8
ICD-10 Finland
Other disorders of autonomic nervous system
+∞
92.7
80
*
G90.9
ICD-10 Finland
Disorder of autonomic nervous system, unspecified
+∞
78.6
69
*
U09.9
ICD-10 Finland
Post COVID-19 condition, unspecified
40.8
26.8
33
10
R53
ICD-10 Finland
Malaise and fatigue
4.4
19.7
81
298
N03AX16
ATC
[U] pregabalin
4.0
16.0
63
219
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
5.9
15.7
32
65
N06AX21
ATC
duloxetine; oral
4.7
14.9
42
113
R03DC03
ATC
montelukast; oral
4.1
14.7
51
161
C07AB07
ATC
bisoprolol; oral
3.5
14.1
99
495
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.4
12.0
35
96
R55
ICD-10 Finland
Syncope and collapse
4.6
11.9
32
82
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
5.3
11.4
25
54
G93.3
ICD-10 Finland
Postviral fatigue syndrome
22.0
11.4
16
8
IDY03
NOMESCO Finland
Systematic individual therapy, cognitive-behavioural
6.2
11.0
20
36
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
5.6
10.9
22
44
R42
ICD-10 Finland
Dizziness and giddiness
3.3
10.7
54
214
3378X
ICD-9 Finland
Disorders of the autonomic nervous system[NEUROPATHIA AUTONOMICA PERIPHERICA ALIA DEFINITA]
+∞
10.5
10
*
R68.88
ICD-10 Finland
Other specified general symptoms and signs, not elsewhere classified.
20.4
10.5
15
8
K59.09
ICD-10 Finland
Constipation, unspecified
5.2
9.6
21
45
H02AA02
ATC
fludrocortisone; oral
105.9
9.5
10
*
N05BA04
ATC
oxazepam; oral
2.9
9.4
62
284
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
8.7
89
505
N03AX12
ATC
[U] gabapentin; oral
3.2
8.6
40
149
N28
ICPC
Limited function/disability (N)
29.3
8.6
11
*
A28
ICPC
Limited function/disability NOS
3.3
8.5
37
132
N06AX16
ATC
venlafaxine; oral
3.2
8.5
41
156
L28
ICPC
Limited function/disability (L)
3.2
8.5
39
144
U09
ICD-10 Finland
Post COVID-19 condition
18.3
8.2
12
7
C07AA05
ATC
propranolol; systemic
2.8
8.2
52
231
XQ800
NOMESCO Finland
Prick test
4.4
8.2
22
56
AA1AD
NOMESCO Finland
CT of head and brain
2.8
8.2
57
266
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.2
8.0
36
131
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
3.6
8.0
29
92
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.7
7.8
57
271
G62.8
ICD-10 Finland
Other specified polyneuropathies
83.7
7.5
8
*
A02BC02
ATC
pantoprazole; systemic
2.7
7.4
120
826
L29
ICPC
Musculoskeletal sympt/complt other
3.6
7.3
26
81
G90.0
ICD-10 Finland
Idiopathic peripheral autonomic neuropathy
+∞
7.3
7
*
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
3.0
7.3
37
144
N06CA01
ATC
amitriptyline and psycholeptics; systemic
3.7
7.3
25
76
Z2446
NOMESCO Finland
Social worker
4.2
7.2
20
52
A06AC01
ATC
ispaghula (psylla seeds); oral
2.7
7.2
51
238
H02AB06
ATC
prednisolone; systemic
2.4
7.2
88
530
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
6.2
7.0
18
32
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
3.0
6.8
34
131
N02AX02
ATC
tramadol; systemic, rectal
2.4
6.8
78
453
Z01.8
ICD-10 Finland
Other specified special examinations
2.6
6.8
49
230
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.2
6.8
30
108
R06.0
ICD-10 Finland
Dyspnoea
2.5
6.7
58
296
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.4
6.7
78
456
A02BA02
ATC
ranitidine; systemic
2.9
6.7
35
139
N03AE01
ATC
clonazepam; systemic
6.0
6.5
17
31
N06AX26
ATC
vortioxetine; oral
3.6
6.4
22
67
M35.7
ICD-10 Finland
Hypermobility syndrome
11.7
6.4
11
10
A99
ICPC
Disease/condition unspecnature/site
3.1
6.4
29
106
N99
ICPC
Neurological disease other
18.9
6.3
9
5
Z02.7
ICD-10 Finland
Issue of medical certificate
3.6
6.3
22
68
A03FA01
ATC
metoclopramide; systemic, rectal
2.5
6.2
47
225
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.6
6.2
41
184
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
13.2
6.2
10
8
H02AB07
ATC
prednisone; oral
3.0
6.2
29
108
Z3226
NOMESCO Finland
Physiotherapist
2.7
6.1
39
172
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
7.7
6.1
13
18
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
6.9
6.0
14
22
UJF30
NOMESCO Finland
Ileoscopy through colon
3.2
6.0
26
92

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
65
214
4.38
18.11
1.6
1.4
1320.00
553.64
titre
—
10
44
93
420
3.80
16.08
2.8
2.1
95.36
205.48
u/l
2.08
88
407
118
688
3.55
12.49
7.4
6.6
0.62
0.70
%
0.75
112
657
111
630
3.36
12.16
3.3
2.5
83.21
75.08
nmol/l
1.83
100
581
38
110
4.19
12.14
3.1
2.4
—
28.10
—
0
8
119
709
3.47
11.92
7.6
6.5
27.77
28.56
%
0.35
114
692
117
691
3.42
11.87
7.4
6.5
2.72
2.76
%
0.08
111
662
124
767
3.53
11.47
8.2
6.5
1.87
1.98
e9/l
0.56
114
691
122
748
3.46
11.44
8.0
6.5
0.04
0.04
e9/l
0.85
109
657
116
695
3.29
11.21
7.4
6.6
8.01
8.55
%
1.81
109
668
121
747
3.36
11.03
8.0
6.5
0.53
0.56
e9/l
0.85
107
659
70
323
3.04
10.68
2.6
1.8
0.52
1.28
mg/l
2.77
52
247
123
779
3.32
10.49
8.4
7.0
0.18
0.19
e9/l
0.09
111
694
100
568
2.95
10.32
6.3
5.1
36.50
36.37
g/l
0.10
92
546
20
40
5.56
9.85
2.5
2.5
24.93
23.79
mmol/l
0.61
20
40
99
572
2.84
9.68
2.6
1.9
101.47
96.97
pmol/l
0.48
58
312
90
499
2.78
9.47
6.6
6.1
—
—
—
0
0
110
685
2.84
9.09
9.9
7.8
1.22
1.21
mmol/l
0.39
99
596
125
835
3.09
9.00
11.9
10.3
3.81
4.05
e9/l
0.71
112
736
21
52
4.48
8.08
1.6
1.6
0.20
0.23
g/l
1.02
21
52
22
60
4.08
7.48
1.8
2.9
6.99
4.91
iu/ml
—
9
11
17
38
4.88
7.37
1.2
1.3
—
—
—
0
0
68
362
2.50
7.32
2.1
1.3
1.95
2.36
g/l
1.12
50
225
35
132
3.10
7.32
1.3
1.3
97.48
117.78
u/ml
0.15
15
56
47
210
2.74
7.23
3.0
2.6
114.66
91.74
ug/g
0.22
38
159
97
612
2.43
7.11
8.5
7.0
1.21
1.22
mmol/l
0.28
91
577
70
383
2.44
7.05
1.8
1.6
20.60
21.11
nmol/l
0.11
64
336
26
87
3.36
6.58
2.8
3.7
7.41
7.42
ph
0.22
21
73
113
783
2.43
6.44
4.8
3.0
123.10
100.78
ug/l
0.20
107
746
74
429
2.32
6.41
5.8
3.8
7.40
7.39
ph
0.69
45
305
12
13
9.85
6.40
1.8
1.1
—
—
—
0
0
70
397
2.33
6.37
1.6
1.3
8.60
1.36
u/ml
0.69
21
110
16
39
4.44
6.25
1.3
1.4
—
—
—
0
0
49
240
2.49
6.16
1.6
1.7
437.76
447.06
pmol/l
0.09
41
208
99
665
2.23
5.83
12.0
11.0
0.00
0.00
e9/l
0.50
78
554
136
1051
2.72
5.72
9.3
8.0
75.43
76.32
u/l
0.11
129
1005
20
63
3.48
5.53
1.6
1.5
9.35
10.31
u/l
0.12
15
52
45
224
2.39
5.39
3.1
2.7
11.76
2.51
e6/l
0.53
19
101
51
271
2.28
5.25
4.2
2.7
530.28
528.71
mosm/kgh2o
0.01
43
245
105
741
2.16
5.23
4.9
6.2
11.41
12.72
umol/l
0.24
98
703
12
19
6.72
5.18
1.2
1.4
18.01
23.04
ng/l
0.33
12
19
68
410
2.13
5.09
4.7
2.8
0.17
0.37
e6/l
1.12
43
300
16
47
3.66
4.89
1.3
1.4
—
—
—
0
0
139
1124
2.55
4.64
6.0
4.4
14.95
14.57
pmol/l
1.23
134
1047
22
82
2.94
4.64
4.2
3.3
—
—
—
0
0
46
246
2.21
4.60
2.1
2.6
2.42
2.43
mmol/l
0.13
40
223
20
71
3.07
4.58
4.1
3.2
25.09
24.04
mmol/l
0.89
20
71
74
475
2.02
4.57
4.7
2.9
18.56
61.11
e6/l
1.63
51
365
15
37
4.36
4.54
1.1
1.2
—
—
—
0
0
59
350
2.07
4.52
5.5
4.9
—
—
—
0
0
57
335
2.08
4.47
4.8
4.6
—
—
—
0
0
11
21
5.53
4.22
1.5
1.1
—
—
—
0
0
68
435
1.96
4.16
5.3
3.0
0.15
0.01
estimate
0.45
20
142
38
198
2.20
4.01
1.3
1.2
—
—
—
0
0
11
23
5.05
3.95
1.9
2.7
92.89
88.84
%
1.07
11
23
17
61
2.99
3.82
1.8
3.7
—
—
—
0
0
11
24
4.83
3.82
1.5
1.2
22.70
21.48
mu/l
0.08
11
24
87
617
1.87
3.80
4.5
3.2
6.13
6.18
ph
0.19
50
339
6
5
12.38
3.79
1.0
2.6
1.44
1.13
ug/l
—
6
5
108
823
1.91
3.75
7.0
5.3
6.79
6.47
mmol/l
0.62
102
763
26
119
2.41
3.68
1.6
1.5
24.39
25.07
iu/l
0.04
20
103
29
140
2.30
3.65
2.5
2.9
28.79
29.24
u/l
0.05
24
115
56
348
1.93
3.65
3.2
2.7
319.66
335.66
umol/l
0.52
47
316
70
469
1.86
3.61
4.0
3.4
2.34
2.35
mmol/l
0.45
62
437
35
184
2.15
3.60
2.0
1.6
1156.10
1165.08
nmol/l
0.02
26
141
72
488
1.85
3.57
4.8
3.6
14.58
40.28
ng/l
2.29
37
319
102
770
1.86
3.57
5.5
3.6
0.00
9.61
estimate
0.50
27
169
82
580
1.83
3.53
11.5
12.8
1.17
1.21
inr
0.29
70
472
6
6
10.31
3.52
2.3
1.2
89.07
152.67
mmol/24h
—
6
6
47
279
1.96
3.48
1.5
1.3
4.33
9.67
u/ml
0.81
18
115
101
765
1.83
3.45
5.5
3.6
0.00
0.00
estimate
-0.00
27
167
7
10
7.25
3.40
1.3
1.3
4.74
9.13
ug/l
—
7
10
32
166
2.15
3.39
1.6
1.7
—
—
—
0
0
42
242
1.99
3.38
5.3
2.9
243.84
146.91
ng/l
0.16
25
160
17
66
2.76
3.33
2.5
2.0
0.00
0.00
estimate
—
8
21
31
160
2.16
3.33
1.5
1.4
—
—
—
0
0
9
19
4.95
3.29
1.4
1.5
0.36
0.46
nmol/l
—
9
19
8
15
5.55
3.23
1.4
1.5
—
—
nmol/l
—
0
0
80
574
1.77
3.20
5.1
3.4
0.17
0.00
estimate
0.48
24
143
24
113
2.32
3.19
4.5
5.4
0.00
0.22
%
—
5
27
101
777
1.78
3.15
5.5
3.7
0.00
0.00
estimate
-0.00
25
155
58
383
1.80
3.04
2.9
1.9
2.48
2.71
mg/l
0.44
50
332
24
116
2.25
3.01
5.0
5.8
0.00
0.36
%
—
5
28
20
89
2.42
3.01
1.2
1.5
0.40
0.23
mg/l
—
8
31
12
37
3.42
3.00
2.3
3.9
9.53
8.69
kpa
0.56
12
37
65
446
1.76
2.98
4.2
3.3
7.90
8.30
mmol/l
0.28
58
382
9
22
4.26
2.93
2.4
3.1
17.90
15.75
%
—
9
22
29
154
2.07
2.89
1.7
3.1
1.56
1.78
%
0.90
22
137
61
415
1.75
2.86
2.3
2.1
—
—
—
0
0
8
18
4.61
2.83
2.3
1.2
—
—
—
0
0
12
40
3.15
2.76
1.1
1.2
2.28
1.87
u/ml
—
7
22
24
121
2.15
2.73
4.5
5.3
0.00
0.86
%
—
5
35
23
114
2.18
2.72
4.0
5.4
0.00
0.78
%
—
5
30
49
318
1.77
2.68
4.2
2.5
5.03
8.28
e6/l
0.53
44
297
75
549
1.67
2.66
5.9
3.6
7.14
58.80
e6/l
2.42
50
383
10
30
3.48
2.65
1.1
1.1
0.20
0.19
u/ml
—
5
14
32
182
1.94
2.64
2.3
3.1
8.26
5.69
umol/l
0.26
27
156
25
130
2.09
2.63
6.8
3.6
7.38
7.39
ph
0.23
16
83
15
62
2.56
2.62
1.9
1.3
—
—
—
0
0
11
36
3.20
2.62
1.7
2.8
7.43
7.42
ph
0.72
11
36
11
36
3.20
2.62
5.4
3.8
3.19
2.76
ratio
—
6
20
115
944
1.73
2.61
7.3
4.3
—
70.73
—
0
11
149
1328
2.33
2.60
8.0
5.3
2.15
1.80
mu/l
0.33
141
1243
8
20
4.15
2.60
1.3
1.1
—
—
—
0
0
15
63
2.52
2.55
1.5
1.4
—
—
—
0
0
58
402
1.69
2.49
5.4
4.2
19.35
10.63
mg/mmol
0.28
38
258
32
186
1.90
2.48
2.3
3.1
4.23
5.40
e9/l
0.45
26
169
47
312
1.71
2.35
1.5
1.3
77.23
27.27
iu/ml
0.73
14
99
64
462
1.63
2.33
7.6
6.5
—
—
—
0
0
9
29
3.22
2.26
2.4
2.8
—
—
—
0
0
11
41
2.80
2.25
1.6
1.5
0.45
0.28
nmol/l
0.33
11
33
5
9
5.69
2.23
1.0
1.0
—
—
—
0
0
5
9
5.69
2.23
1.0
1.0
—
—
—
0
0
5
9
5.69
2.23
1.0
1.0
—
—
—
0
0
17
81
2.23
2.22
2.4
1.9
—
—
—
0
0
56
396
1.63
2.19
4.4
3.6
31.23
71.27
mg/l
1.55
36
260
6
14
4.40
2.17
1.3
3.8
1.73
1.42
nmol/l
—
6
14
19
96
2.11
2.16
6.3
6.4
25.20
24.65
mmol/l
0.42
19
96
24
133
1.94
2.13
9.5
11.8
1.38
1.22
mmol/l
0.12
18
111
16
76
2.22
2.10
2.6
2.0
20.63
21.30
s
0.22
16
69
5
10
5.12
2.08
1.4
3.6
347.40
920.00
u/ml
—
5
10
23
127
1.94
2.07
2.8
2.0
0.00
0.00
estimate
—
9
30
8
26
3.18
2.04
1.1
1.0
—
—
—
0
0
9
32
2.92
2.03
1.2
1.8
—
—
—
0
0
17
85
2.12
1.98
1.4
1.2
—
—
—
0
0
11
46
2.49
1.89
1.3
1.1
—
—
—
0
0
8
28
2.95
1.89
2.0
2.1
4.84
5.03
kpa
—
8
28
8
28
2.95
1.89
2.0
2.1
9.59
8.39
kpa
—
8
28
17
87
2.06
1.88
1.4
1.1
—
—
—
0
0
7
23
3.13
1.82
4.1
2.7
5.17
10.23
pmol/l
—
7
23
21
119
1.88
1.76
1.6
3.2
65.15
68.94
e9/l
0.37
15
89
11
48
2.38
1.74
1.0
1.6
—
—
—
0
0
23
135
1.82
1.73
10.6
11.7
7.40
7.42
ph
0.21
11
78
5
13
3.93
1.73
1.4
1.7
221.60
192.62
e6/l
—
5
13
153
1423
2.12
1.64
25.4
14.0
17.26
21.61
mg/l
1.37
125
1141
7
26
2.77
1.60
1.0
1.2
—
—
—
0
0
55
414
1.49
1.57
4.3
3.7
0.00
0.00
estimate
-0.00
25
157
11
51
2.24
1.54
1.5
1.1
—
—
—
0
0
57
436
1.47
1.50
4.6
3.4
—
—
—
0
0
34
234
1.57
1.45
1.6
1.6
—
—
—
0
0
10
46
2.25
1.43
1.0
1.1
—
—
—
0
0
13
67
2.02
1.43
2.5
1.7
—
—
—
0
0
24
152
1.68
1.42
1.3
1.2
—
—
—
0
0
7
29
2.48
1.41
2.0
2.8
140.00
126.20
g/l
—
7
20
52
395
1.46
1.41
3.8
2.9
—
—
—
0
0
73
594
1.41
1.36
2.4
2.0
—
—
—
0
0
6
24
2.56
1.31
1.3
1.4
—
—
—
0
0
118
1048
1.45
1.31
3.6
3.2
49.74
43.20
u/l
0.21
112
1005
143
1324
1.63
1.26
4.9
4.6
6.07
5.80
mmol/l
0.75
135
1233
19
117
1.71
1.24
10.4
8.7
—
—
—
0
0
138
1269
1.55
1.24
6.8
5.6
39.18
38.33
mmol/mol
0.46
130
1206
59
469
1.40
1.23
1.9
2.2
—
—
—
0
0
26
177
1.56
1.17
1.7
1.5
—
—
—
0
0
5
20
2.55
1.16
1.0
1.3
—
—
—
0
0
20
132
1.59
1.03
5.8
3.5
—
—
—
0
0
10
172
0.55
1.00
1.3
1.4
—
—
—
0
0
42
326
1.39
0.99
4.2
3.6
1.02
1.02
kg/l
0.04
27
206
22
150
1.54
0.99
1.4
1.4
—
—
—
0
0
18
117
1.60
0.98
2.9
2.3
6.44
6.10
ph
—
9
77
7
36
1.99
0.98
1.0
1.1
—
—
—
0
0
13
78
1.72
0.94
1.0
1.4
—
—
—
0
0
154
1477
1.70
0.84
19.1
12.5
—
—
—
0
0
33
255
1.37
0.80
1.7
1.9
—
—
—
0
0
0
24
0.00
0.80
0.0
4.4
—
20.34
—
0
19
11
67
1.69
0.77
7.3
11.2
—
—
—
0
0
5
26
1.95
0.71
1.0
1.2
—
—
—
0
0
5
26
1.95
0.71
2.4
2.4
3.65
3.82
e9/l
—
5
26
70
611
1.25
0.70
2.2
1.9
1.65
1.41
mmol/l
0.80
58
526
7
42
1.70
0.69
1.0
1.2
—
—
—
0
0
11
71
1.59
0.64
4.2
2.5
0.48
0.65
%
1.40
11
71
8
49
1.66
0.63
1.3
1.2
—
—
—
0
0
13
88
1.52
0.62
2.2
1.5
—
—
—
0
0
8
50
1.63
0.62
1.0
1.1
—
—
—
0
0
8
51
1.60
0.61
1.6
2.3
—
—
—
0
0
11
73
1.54
0.58
4.2
2.5
0.79
1.24
%
2.08
11
73
6
36
1.69
0.57
1.0
1.1
—
—
—
0
0
40
471
0.80
0.55
1.3
1.6
—
—
—
0
0
9
61
1.50
0.55
2.2
1.5
—
—
—
0
0
13
92
1.45
0.52
2.2
1.5
—
—
—
0
0
7
45
1.58
0.49
1.3
1.2
—
100.00
—
0
6
16
120
1.37
0.48
1.3
1.4
—
—
—
0
0
21
166
1.30
0.46
1.4
1.3
—
—
—
0
0
7
50
1.42
0.45
14.4
12.8
0.99
0.85
%
—
7
45
25
203
1.27
0.45
2.0
2.2
—
—
—
0
0
13
95
1.40
0.45
2.2
1.5
—
—
—
0
0
13
172
0.73
0.43
1.8
2.0
—
—
—
0
0
13
96
1.38
0.43
2.2
1.5
—
—
—
0
0
28
233
1.24
0.42
1.4
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
3.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
14
108
1.32
0.36
1.5
1.7
—
—
—
0
0
7
54
1.31
0.31
14.4
12.1
1.74
1.62
%
—
7
49
11
86
1.30
0.27
1.0
1.1
—
—
—
0
0
22
189
1.19
0.26
1.6
1.2
—
—
—
0
0
12
96
1.27
0.25
1.2
1.1
—
—
—
0
0
141
1377
1.17
0.24
5.4
4.7
4.73
4.65
mmol/l
0.39
134
1301
5
40
1.26
0.22
2.6
2.1
52.80
58.09
%
—
5
40
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
58
616
0.91
0.19
3.0
2.9
—
—
—
0
0
140
1376
1.12
0.15
5.4
4.6
1.43
1.46
mmol/l
0.41
132
1290
11
94
1.18
0.13
2.4
1.5
—
—
—
0
0
141
1390
1.10
0.12
6.1
5.2
2.86
2.73
mmol/l
0.91
135
1309
5
60
0.83
0.08
3.6
4.8
36.94
37.03
°c
—
5
60
6
71
0.84
0.08
1.2
1.0
1.59
1.59
g/l
—
6
71
6
74
0.80
0.07
1.2
1.1
1.02
0.85
g/l
—
6
74
133
1315
1.06
0.07
4.6
3.9
1.43
1.26
mmol/l
1.22
125
1222
67
684
0.97
0.05
2.6
2.8
—
—
estimate
—
0
0
22
228
0.96
0.02
3.7
3.1
0.65
0.77
ug/l
0.48
15
150
35
353
0.99
0.00
1.8
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
18.03
—
0
6
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
134.29
—
0
7
0
6
0.00
-0.00
0.0
3.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
8.55
—
0
8
156
1553
1.09
-0.00
37.3
22.1
135.44
135.70
g/l
0.08
156
1536
0
5
0.00
-0.00
0.0
1.6
—
15.08
—
0
5
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
177.40
—
0
5
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint G6_AUTOTHUNS and mortality.

Females

Parameter HR [95% CI] p-value
G6_AUTOTHUNS 2.676 [1.8, 3.98] < 0.001
Birth year 0.995 [0.99, 1.0] 0.258

During the follow-up period (1.1.1998 — 31.12.2019), 87 out of 362 females with G6_AUTOTHUNS died.

Males

Parameter HR [95% CI] p-value
G6_AUTOTHUNS 2.681 [2.0, 3.6] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 159 out of 402 males with G6_AUTOTHUNS died.

Mortality risk

Mortality risk for people of age

years, who have G6_AUTOTHUNS.

N-year risk Females Males
1 0.252% 0.419%
5 1.563% 3.014%
10 3.867% 7.291%
15 7.165% 13.851%
20 12.414% 22.741%

Relationships between endpoints

Index endpoint: G6_AUTOTHUNS – Other and unspecified disorders of autonomic nervous system

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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