No definition available.
Multiple system atrophy (rare forms of Parkinsonism)
G6_MULTIPLE_SYSTEM_ATROPHY
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
117 |
4. Check minimum number of eventsNone |
117 |
5. Include endpointsNone |
117 |
6. Filter based on genotype QC (FinnGen only) |
104 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Similar endpoints
↥List of similar endpoints to
Multiple system atrophy (rare forms of Parkinsonism)
based on the number of shared cases.
Similar with more cases:
- Autonomic disorders
- Other neurological diseases
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 104 | 44 | 60 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | 70.80 | 70.35 | 71.13 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 105
- Matched controls
- 1050
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G90.3
ICD-10 Finland
Multi-system degeneration
+∞
151.4
105
*
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
123.8
129.1
73
19
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
125.9
112.4
60
11
G20
ICD-10 Finland
Parkinson disease
115.3
110.6
60
12
N87
ICPC
Parkinsonism
152.6
38.9
39
*
N04BC05
ATC
pramipexole; oral
11.8
30.7
39
50
N04BD01
ATC
selegiline; oral
102.3
22.8
24
*
N04BA03
ATC
levodopa, decarboxylase inhibitor and COMT inhibitor; oral
214.8
18.1
18
*
H02AA02
ATC
fludrocortisone; oral
51.7
18.1
21
5
N04BC04
ATC
ropinirole; oral
200.6
17.0
17
*
N04BD02
ATC
rasagiline; oral
173.1
14.9
15
*
G23.2
ICD-10 Finland
Multiple system atrophy, parkinsonian type [MSA-P]
134.1
11.7
12
*
193
Kela drug reimbursment
Rasagiline
134.1
11.7
12
*
XF606
NOMESCO Finland
Ortostatic test
+∞
11.7
11
*
R4130
NOMESCO Finland
Speech therapy
16.6
10.9
17
12
G23.3
ICD-10 Finland
Multiple system atrophy, cerebellar type [MSA-C]
+∞
10.6
10
*
I95.1
ICD-10 Finland
Orthostatic hypotension
8.7
10.2
22
31
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.5
9.6
21
46
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
40.5
9.2
11
*
N28
ICPC
Limited function/disability (N)
18.3
8.8
13
8
G21.9
ICD-10 Finland
Secondary parkinsonism, unspecified
97.6
8.5
9
*
G23.9
ICD-10 Finland
Degenerative disease of basal ganglia, unspecified
97.6
8.5
9
*
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
16.2
8.5
13
9
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.1
7.5
17
38
N03AE01
ATC
clonazepam; systemic
9.0
7.4
15
19
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
10.4
7.0
13
14
SPAT1229
SPAT
Assessment of need for aid
4.8
6.8
17
41
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.5
6.8
18
46
L89
ICD-10 Finland
Decubitus ulcer and pressure area
13.5
6.8
11
9
G23.8
ICD-10 Finland
Other specified degenerative diseases of basal ganglia
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
59
811
0.38
5.48
4.7
5.9
5.93
6.13
mmol/l
0.76
54
731
11
343
0.24
5.36
2.3
2.0
1.16
1.32
mmol/l
0.47
11
276
68
865
0.39
4.65
9.2
13.9
20.24
24.27
u/l
1.92
62
838
57
778
0.42
4.59
3.6
4.8
1.17
1.28
mmol/l
0.71
50
699
48
670
0.48
3.40
32.3
25.2
13.87
13.94
%
0.13
48
664
31
172
2.14
2.92
2.8
3.1
0.63
0.86
e6/l
0.39
21
102
16
66
2.68
2.87
2.2
4.3
25.79
23.95
mmol/l
1.02
16
66
55
708
0.53
2.56
4.8
9.1
79.37
83.06
u/l
0.23
49
667
14
283
0.42
2.47
6.9
3.7
0.00
0.00
estimate
—
5
92
63
772
0.54
2.34
5.1
5.7
1.86
2.04
mu/l
0.90
56
684
7
18
4.09
2.29
1.9
1.6
—
—
—
0
0
7
18
4.09
2.29
1.9
1.6
—
—
—
0
0
38
534
0.55
2.24
3.4
7.1
10.82
12.16
umol/l
0.61
33
502
20
110
2.01
1.89
7.5
9.1
—
—
—
0
0
26
158
1.86
1.85
2.9
3.3
2.64
1.72
e6/l
0.18
16
89
29
185
1.78
1.77
1.6
1.7
1040.47
1188.01
nmol/l
0.41
23
147
27
384
0.60
1.46
4.0
6.3
3.39
2.59
ug/l
0.23
22
344
25
354
0.61
1.29
3.4
4.2
14.58
11.08
mg/mmol
0.14
16
226
39
294
1.52
1.20
4.0
3.3
0.88
0.37
e6/l
0.52
31
227
0
34
0.00
1.18
0.0
1.6
—
—
—
0
0
11
58
2.00
1.17
1.8
2.6
0.55
0.62
%
0.44
11
58
0
36
0.00
1.16
0.0
1.3
—
1.79
—
0
8
0
36
0.00
1.16
0.0
2.3
—
3.29
—
0
27
36
271
1.50
1.10
2.6
2.2
2.86
2.86
mg/l
0.00
31
239
75
831
0.66
1.06
21.7
19.3
33.48
25.68
mg/l
0.97
66
711
11
61
1.90
1.03
1.8
2.6
1.09
1.12
%
0.05
11
61
29
212
1.51
1.01
2.0
2.4
—
—
—
0
0
22
151
1.58
1.01
9.8
7.2
103.95
104.09
mmol/l
0.04
22
151
0
31
0.00
0.98
0.0
1.2
—
—
—
0
0
19
127
1.61
0.97
1.8
2.0
—
—
—
0
0
19
129
1.58
0.91
1.8
1.9
—
—
—
0
0
55
634
0.72
0.86
4.1
4.5
14.98
15.07
pmol/l
0.08
47
560
30
382
0.70
0.86
6.2
4.4
0.40
0.00
estimate
—
5
95
41
494
0.72
0.84
5.7
4.3
0.17
0.00
estimate
—
6
115
19
134
1.51
0.78
4.5
5.7
0.96
1.06
mmol/l
1.26
19
126
5
24
2.14
0.75
1.0
2.0
—
—
—
0
0
36
434
0.74
0.71
5.0
4.7
32.85
43.90
ng/l
0.42
27
336
43
505
0.75
0.71
5.5
4.3
0.00
0.00
estimate
—
5
104
46
535
0.75
0.71
5.3
11.0
5.79
4.31
e9/l
0.70
40
472
15
103
1.53
0.69
12.6
8.4
114.20
119.79
g/l
0.45
15
103
35
422
0.74
0.69
2.2
2.3
—
—
—
0
0
36
430
0.75
0.66
2.5
2.8
—
—
estimate
—
0
0
44
372
1.31
0.65
4.1
3.4
—
—
—
0
0
8
52
1.58
0.61
7.9
8.3
14.09
14.85
%
—
8
52
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
12
81
1.54
0.60
9.7
7.9
0.89
1.24
mmol/l
2.59
12
81
19
247
0.72
0.59
3.5
3.3
340.71
352.29
umol/l
0.21
14
206
9
64
1.44
0.53
14.4
8.0
27.82
24.63
mmol/l
—
9
64
25
200
1.33
0.53
1.5
1.8
1.36
1.41
mg/l
0.05
20
166
44
496
0.81
0.46
5.3
4.3
0.00
14.00
estimate
—
6
116
8
59
1.38
0.42
1.4
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
2.9
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
250.83
—
0
6
0
15
0.00
0.41
0.0
3.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.4
—
2.39
—
0
17
0
17
0.00
0.41
0.0
1.4
—
—
—
0
0
26
307
0.80
0.40
2.9
5.2
18.85
22.14
%
—
10
166
0
19
0.00
0.39
0.0
1.5
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
152.71
—
0
7
6
45
1.35
0.34
5.7
5.6
28.07
29.23
mg/l
—
6
38
6
45
1.35
0.34
5.7
5.6
44.38
182.86
mg/l
—
6
38
21
179
1.22
0.28
1.8
2.0
—
—
—
0
0
5
73
0.67
0.27
1.4
2.1
13.80
13.48
nmol/l
—
5
67
7
92
0.74
0.23
1.0
1.4
—
—
—
0
0
24
211
1.18
0.23
5.0
4.8
1.02
1.02
kg/l
0.59
13
147
0
11
0.00
0.21
0.0
3.6
—
112.06
—
0
11
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
48
448
1.13
0.21
10.4
6.5
1.20
1.21
mmol/l
0.79
42
412
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
7
61
1.16
0.18
1.4
1.8
—
—
—
0
0
20
222
0.88
0.15
2.3
3.2
0.53
0.89
ug/l
0.93
15
158
7
85
0.81
0.15
1.3
1.4
—
—
—
0
0
27
293
0.89
0.15
6.4
4.3
0.00
0.00
estimate
—
5
104
8
97
0.81
0.14
1.5
3.6
4.88
8.49
umol/l
—
8
83
10
117
0.84
0.14
5.8
3.5
—
—
—
0
0
45
428
1.09
0.12
3.0
2.3
86.81
92.60
pmol/l
0.48
25
229
20
182
1.12
0.12
3.2
2.9
0.86
0.82
mmol/l
0.97
20
169
48
496
0.94
0.07
7.2
7.4
1.21
1.21
mmol/l
0.19
42
428
39
400
0.96
0.03
4.4
3.0
129.74
129.95
ug/l
0.00
34
367
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
5.1
—
0.87
—
0
8
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
9.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
176.11
—
0
9
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
5.7
—
4.54
—
0
7
0
9
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
97.40
—
0
5
0
7
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
7.7
—
213.17
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
61.00
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
77
0.90
-0.00
1.6
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
13.68
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
9.67
—
0
6
0
9
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
8.71
—
0
7
0
7
0.00
-0.00
0.0
1.3
—
15.57
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
8
88
0.90
-0.00
2.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
26.20
—
0
5
0
7
0.00
-0.00
0.0
1.3
—
95.43
—
0
7
0
7
0.00
-0.00
0.0
5.7
—
9.66
—
0
7
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: G6_MULTIPLE_SYSTEM_ATROPHY – Multiple system atrophy (rare forms of Parkinsonism)
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).