Ankylosis of joint

M13_ANKYLOSISJOINT

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M24.6
  • Hospital discharge: ICD-9 7185
  • Hospital discharge: ICD-8 727
  • Cause of death: ICD-10 M24.6
  • Cause of death: ICD-9 7185
  • Cause of death: ICD-8 727

2 out of 7 registries used, show all original rules.

237

4. Check minimum number of events

None

237

5. Include endpoints

None

237

6. Filter based on genotype QC (FinnGen only)

207

Control definitions (FinnGen only)

Control exclude
M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M24
Name in latin
Ancylosis articulationis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2284 1149 1101
Only index persons 1575 851 724
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.03 0.03 0.03
Median age at first event (years)
Whole population 50.86 50.73 50.88
Only index persons 45.49 46.78 43.99

-FinnGen-

Key figures

All Female Male
Number of individuals 207 109 98
Unadjusted period prevalence (%) 0.04 0.04 0.04
Median age at first event (years) 47.44 47.01 47.93

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
215
Matched controls
2150
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M24.6
ICD-10 Finland
Ankylosis of joint
+∞
117.9
102
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
23.1
72.2
57
33
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
38.7
36
*
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
13.7
36.1
36
31
72710
ICD-8 Finland
Ankylosis of joint, Of shoulder
+∞
27.7
26
*
M16.1
ICD-10 Finland
Other primary coxarthrosis
28.5
26.7
36
15
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
10.3
26.6
32
36
M19.0
ICD-10 Finland
Primary arthrosis of other joints
28.6
25.3
34
14
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
67.1
21.4
24
*
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
51.2
19.6
23
5
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
60.9
19.3
22
*
NGT60
NOMESCO Finland
Forcible manipulation of knee joint
+∞
18.0
17
*
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
+∞
16.9
16
*
L15
ICPC
Knee symptom/complaint
4.0
16.5
58
182
M25.5
ICD-10 Finland
Pain in joint
3.8
16.1
61
202
72700
ICD-8 Finland
Ankylosis of joint, Of spine
+∞
15.8
15
*
B01AB05
ATC
enoxaparin; parenteral
3.3
14.6
78
319
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
45.9
14.3
17
*
Z01.8
ICD-10 Finland
Other specified special examinations
3.3
13.8
67
258
WX320
NOMESCO Finland
Spinalanesthesy
3.5
13.3
55
191
M01AH01
ATC
celecoxib; oral
3.8
12.9
45
139
WX111
NOMESCO Finland
Local infiltration anesthesia
+∞
12.6
12
*
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
5.3
12.5
27
57
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.8
12.1
93
459
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
+∞
11.6
11
*
NF1AA
NOMESCO Finland
Hip X-ray examination
5.1
11.5
26
57
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
37.2
11.4
14
*
N03AX12
ATC
[U] gabapentin; oral
3.6
11.3
42
135
71301
ICD-8 Finland
Osteo-arthritis and allied conditions, Arthritis (arthrosis) genus
+∞
10.5
10
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
9.2
10.3
21
25
M48.0
ICD-10 Finland
Spinal stenosis
3.6
10.3
37
116
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.3
10.2
43
150
M01AX05
ATC
glucosamine; oral
3.3
9.9
43
152
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.6
9.8
88
459
NGC30
NOMESCO Finland
Secondary implantation of prosthesis in knee joint, special prosthesis
+∞
9.4
9
*
72799
ICD-8 Finland
Ankylosis of joint, Of unspecified site
+∞
9.4
9
*
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
12.2
9.2
16
14
N02AX02
ATC
tramadol; systemic, rectal
2.4
8.9
94
525
NDE60
NOMESCO Finland
Incision and release of adhesions in joint of finger or metacarpal
52.2
8.7
10
*
M09AX01
ATC
hyaluronic acid; parenteral
9.6
8.7
17
19
R51.80
ICD-10 Finland
Headache
3.0
8.7
44
170
1220
FHL
Arthroscopy
17.2
8.7
13
8
S18
ICPC
Laceration/cut
2.3
8.6
103
605
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
28.8
8.6
11
*
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
13.5
8.5
14
11
72760
ICD-8 Finland
Ankylosis of joint, Of knee
+∞
8.4
8
*
72770
ICD-8 Finland
Ankylosis of joint, Of ankle
+∞
8.4
8
*
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
8.1
8.4
18
24
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.3
7.8
21
53
ACC51
NOMESCO Finland
Release of median nerve
4.8
7.8
18
40
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
46.7
7.8
9
*
L13
ICPC
Hip symptom/complaint
2.9
7.8
42
168
L12
ICPC
Hand/finger symptom/complaint
2.9
7.7
41
163
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
26.1
7.6
10
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
4.1
7.5
21
55
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
11.4
7.4
13
12
9294
FHL
Endoprosthesis replacement of the entire hip joint (eg Charnley)
+∞
7.3
7
*
M01AH02
ATC
rofecoxib; oral
3.1
7.2
32
114
9253
FHL
Manipulation under anesthesia or regression and plastering
31.2
7.2
9
*
M79.6
ICD-10 Finland
Pain in limb
2.2
7.2
85
489
R4120
NOMESCO Finland
Occupational therapy
4.6
7.1
17
39
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
4.1
7.0
20
53
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.9
6.9
21
58
M20.1
ICD-10 Finland
Hallux valgus (acquired)
11.5
6.9
12
11
NDU20
NOMESCO Finland
Removal of internal fixation device from wrist or hand
17.4
6.8
10
6
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
41.4
6.8
8
*
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.8
6.8
21
59
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.5
6.6
46
209
L90
ICPC
Osteoarthrosis of knee
7.8
6.5
14
19
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
71.9
6.5
7
*
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
6.3
6.4
16
27
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
6.4
79
457
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
18.7
6.3
9
5
9271
FHL
Hallux surgery
+∞
6.3
6
*
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
+∞
6.3
6
*
M01AH05
ATC
etoricoxib; oral
2.1
6.3
111
735
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.2
6.2
61
322
B01AF01
ATC
rivaroxaban; oral
3.2
6.2
25
84
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
4.2
6.0
16
40

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
39
165
2.67
6.43
1.4
1.1
1.25
1.67
u/ml
—
8
69
78
490
1.93
4.83
2.4
2.2
247.74
215.25
u/l
0.13
72
464
41
208
2.20
4.50
1.4
1.2
11.83
16.96
iu/ml
0.73
11
59
105
743
1.81
4.36
4.5
4.5
35.67
35.55
g/l
0.08
98
698
56
341
1.87
3.69
2.6
2.7
355.00
352.67
umol/l
0.04
47
290
113
847
1.70
3.62
6.8
6.6
1.22
1.21
mmol/l
0.51
101
726
75
505
1.75
3.53
3.9
4.9
—
—
—
0
0
50
316
1.76
2.88
1.3
1.4
3.12
2.46
g/l
0.77
26
201
18
79
2.40
2.76
1.1
1.4
—
62.50
—
0
10
97
735
1.58
2.75
2.5
2.1
90.02
94.08
pmol/l
0.36
50
383
22
106
2.20
2.74
1.1
2.5
—
—
—
0
0
35
201
1.89
2.73
1.4
1.2
—
—
—
0
0
32
180
1.91
2.66
2.1
1.8
—
—
—
0
0
93
703
1.57
2.64
3.0
2.7
131.07
113.47
ug/l
0.37
84
648
89
667
1.57
2.62
2.8
2.6
—
—
estimate
—
0
0
54
359
1.67
2.58
1.4
1.3
8.94
1.45
u/ml
0.63
14
101
60
412
1.63
2.52
2.1
1.9
2.48
3.22
mg/l
1.64
47
347
92
715
1.50
2.21
5.4
5.6
8.69
9.07
%
0.67
85
664
28
162
1.84
2.15
7.1
4.3
7.29
7.36
ph
0.36
22
110
91
714
1.48
2.05
5.4
5.5
2.83
2.84
%
0.02
84
664
91
714
1.48
2.05
5.4
5.5
0.69
0.70
%
0.06
85
658
100
801
1.46
2.02
13.7
13.5
1.36
1.27
inr
0.69
83
686
66
487
1.51
2.00
1.7
1.6
25.09
20.02
nmol/l
0.68
56
395
69
515
1.50
1.98
2.4
2.4
52.52
72.71
u/l
0.98
64
478
92
728
1.46
1.97
5.3
5.6
26.54
26.90
%
0.12
87
688
100
806
1.45
1.93
5.0
5.6
0.19
0.19
e9/l
0.02
83
686
98
788
1.45
1.91
5.0
5.5
1.78
1.81
e9/l
0.14
82
685
96
770
1.45
1.89
5.1
5.4
0.58
0.59
e9/l
0.21
79
652
96
773
1.44
1.84
5.1
5.4
0.04
0.04
e9/l
0.54
79
656
12
53
2.34
1.84
1.0
1.2
—
—
—
0
0
15
75
2.08
1.74
2.7
2.4
—
—
—
0
0
105
869
1.41
1.69
5.6
6.8
10.23
12.40
umol/l
1.91
98
832
10
40
2.57
1.69
1.0
1.2
—
—
—
0
0
89
719
1.41
1.63
5.2
5.4
59.13
57.79
%
0.46
84
678
26
161
1.70
1.62
2.0
1.7
—
—
—
0
0
7
26
2.75
1.59
1.3
1.0
—
—
—
0
0
44
598
0.67
1.59
3.7
3.3
—
—
—
0
0
68
526
1.43
1.59
3.5
4.2
7.39
7.40
ph
0.54
53
367
13
64
2.10
1.57
1.0
1.2
—
—
—
0
0
21
124
1.77
1.54
1.2
3.1
69.07
66.19
g/l
1.21
16
113
28
180
1.64
1.52
1.4
2.5
93.66
126.67
ug/g
0.51
18
142
23
142
1.69
1.45
3.1
3.3
—
—
—
0
0
45
327
1.48
1.45
1.6
1.6
0.72
1.24
mg/l
2.20
38
255
5
16
3.17
1.44
1.2
1.3
—
—
—
0
0
5
16
3.17
1.44
1.2
1.3
—
—
—
0
0
14
77
1.88
1.28
1.3
1.3
—
—
—
0
0
79
659
1.31
1.11
5.1
4.1
31.83
51.40
ng/l
0.85
65
501
103
893
1.29
1.08
7.6
9.5
4.41
4.21
e9/l
0.40
88
766
59
475
1.33
1.05
3.8
4.1
—
—
—
0
0
135
1215
1.30
1.05
5.6
3.9
15.31
14.92
pmol/l
0.99
123
1097
19
123
1.60
1.03
1.5
2.6
10.77
10.53
g/l
0.13
19
111
58
467
1.33
1.03
2.5
2.3
—
—
—
0
0
24
165
1.51
1.02
1.3
1.5
—
—
—
0
0
9
48
1.91
1.02
2.0
2.7
—
—
—
0
0
17
109
1.61
0.97
1.4
1.2
—
—
—
0
0
56
457
1.30
0.91
5.3
6.7
—
—
—
0
0
8
42
1.94
0.89
1.1
1.3
—
—
—
0
0
17
113
1.55
0.85
5.2
2.9
7.40
7.42
ph
1.31
12
96
64
539
1.27
0.81
3.2
3.3
65.10
56.28
mg/l
0.09
45
351
160
1497
1.27
0.78
7.0
6.4
39.63
39.80
mmol/mol
0.09
153
1370
0
28
0.00
0.76
0.0
1.3
—
—
—
0
0
65
553
1.25
0.76
3.2
3.2
7.30
7.51
mmol/l
0.16
56
462
9
56
1.63
0.73
1.4
1.7
—
11.50
—
0
11
9
56
1.63
0.73
1.6
1.3
16.74
29.49
iu/l
—
9
45
28
213
1.36
0.73
1.4
1.5
—
—
—
0
0
74
642
1.23
0.72
1.8
1.9
1.43
1.29
mmol/l
0.67
63
514
7
41
1.73
0.70
1.3
1.3
—
—
—
0
0
10
61
1.67
0.70
2.9
3.4
184.32
339.46
mg/l
—
5
28
7
42
1.69
0.69
1.3
1.3
—
—
—
0
0
7
42
1.69
0.69
1.3
1.3
—
—
—
0
0
7
42
1.69
0.69
1.3
1.3
—
—
—
0
0
5
27
1.87
0.69
1.2
1.7
—
—
—
0
0
38
306
1.29
0.69
1.8
1.7
1102.90
1161.68
nmol/l
0.16
30
231
27
345
0.75
0.67
3.9
3.1
0.96
0.94
ug/l
0.02
18
221
34
271
1.30
0.66
2.4
2.8
1.41
1.60
e6/l
0.07
17
130
8
128
0.61
0.66
1.3
1.4
—
—
—
0
0
76
671
1.21
0.61
3.4
3.5
6.39
6.25
ph
0.51
35
401
39
469
0.79
0.61
3.3
3.4
0.00
0.00
estimate
—
10
136
166
1576
1.23
0.61
20.0
15.1
25.94
27.06
mg/l
0.16
137
1254
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
120
1292
0.84
0.60
22.0
18.8
13.84
13.72
%
0.50
120
1277
0
22
0.00
0.59
0.0
2.6
—
15.38
—
0
16
0
23
0.00
0.58
0.0
1.4
—
274.13
—
0
15
155
1469
1.20
0.54
6.8
4.9
1.86
1.93
mu/l
0.39
144
1327
6
39
1.55
0.53
1.3
1.3
—
—
—
0
0
63
711
0.84
0.53
8.7
10.2
0.00
0.00
e9/l
1.96
49
574
45
383
1.22
0.52
4.9
3.9
1.02
1.02
kg/l
0.12
24
259
116
1077
1.17
0.50
4.6
4.2
—
0.82
—
0
5
7
46
1.54
0.49
1.1
1.1
—
—
—
0
0
17
130
1.33
0.45
2.5
2.7
5.79
6.09
ph
0.95
12
85
9
130
0.68
0.44
4.0
3.4
—
—
—
0
0
5
32
1.58
0.42
1.0
1.3
—
—
—
0
0
5
33
1.53
0.41
1.0
5.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.4
—
102.67
—
0
15
0
15
0.00
0.41
0.0
1.6
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
0.23
—
0
8
0
16
0.00
0.41
0.0
2.3
—
0.88
—
0
16
0
16
0.00
0.41
0.0
2.1
—
7.20
—
0
11
23
187
1.26
0.41
3.2
4.7
3.30
61.90
ug/l
1.00
18
172
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
2.2
—
0.78
—
0
11
0
18
0.00
0.40
0.0
2.4
—
31.94
—
0
18
61
548
1.16
0.40
3.9
4.0
2.48
11.33
mg/mmol
3.16
42
354
5
78
0.63
0.36
2.0
3.0
3.02
1.44
%
—
5
71
18
145
1.26
0.35
1.2
1.4
—
—
—
0
0
13
164
0.78
0.32
1.8
3.0
3.89
4.43
kpa
0.73
13
156
11
84
1.33
0.30
6.7
2.6
—
—
—
0
0
58
530
1.13
0.30
3.1
3.4
—
—
—
0
0
17
139
1.24
0.30
1.5
1.5
—
—
—
0
0
8
106
0.75
0.29
1.8
2.8
1.58
1.32
%
—
8
106
8
66
1.22
0.27
1.1
1.2
—
—
—
0
0
9
73
1.24
0.26
1.7
2.0
—
—
—
0
0
36
323
1.14
0.25
3.5
3.9
109.94
355.52
ng/l
1.04
31
261
21
242
0.85
0.23
1.9
1.9
—
—
—
0
0
18
153
1.19
0.23
2.0
2.5
53.85
70.27
e9/l
2.06
11
113
64
599
1.10
0.22
3.5
4.0
89.06
85.76
e6/l
0.03
47
425
90
856
1.09
0.22
4.1
3.9
0.00
0.00
estimate
-0.00
14
176
5
42
1.19
0.21
1.0
2.0
22.00
36.84
umol/l
—
5
37
8
104
0.76
0.21
1.8
2.8
0.64
0.64
%
—
8
104
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
69.45
—
0
11
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
17.28
—
0
10
16
187
0.84
0.21
1.1
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.7
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
9
113
0.79
0.20
1.8
2.8
128.11
128.54
g/l
—
9
108
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
49
458
1.09
0.17
2.9
3.2
0.19
0.55
e6/l
1.02
39
335
57
537
1.08
0.17
3.0
3.3
28.25
50.36
e6/l
0.68
47
407
90
864
1.07
0.16
4.0
3.9
0.00
0.02
estimate
0.50
14
168
18
203
0.88
0.16
1.3
1.3
—
—
—
0
0
166
1629
1.08
0.16
16.8
13.5
—
—
—
0
0
9
83
1.09
0.15
5.8
4.2
37.10
37.00
°c
—
9
83
10
118
0.84
0.14
1.7
1.4
—
—
—
0
0
17
152
1.13
0.12
6.8
6.3
12.09
10.00
mmol/l
0.56
17
144
160
1574
1.06
0.12
6.2
5.7
2.54
2.65
mmol/l
0.88
151
1439
17
153
1.12
0.11
6.1
8.2
—
—
—
0
0
156
1537
1.05
0.10
5.4
4.9
1.46
1.47
mmol/l
0.09
147
1397
64
662
0.95
0.09
4.2
3.9
0.00
0.01
estimate
0.50
12
147
157
1549
1.05
0.09
5.5
5.0
4.40
4.57
mmol/l
1.43
152
1424
20
185
1.09
0.08
1.4
1.5
—
—
—
0
0
5
60
0.83
0.08
1.8
1.6
—
—
—
0
0
7
64
1.10
0.08
1.0
1.1
—
—
—
0
0
19
205
0.92
0.08
6.1
6.6
5.06
5.05
kpa
0.03
19
194
19
205
0.92
0.08
6.1
6.6
11.72
11.59
kpa
0.05
19
197
52
501
1.05
0.08
4.6
3.7
0.00
0.00
estimate
-0.00
13
163
174
1722
1.05
0.08
28.8
22.7
4.40
4.47
e12/l
0.91
169
1665
174
1722
1.05
0.08
28.9
22.8
6.68
6.72
e9/l
0.14
169
1664
17
184
0.92
0.07
2.5
3.7
7.35
7.39
ph
—
7
110
13
118
1.11
0.07
4.5
3.3
—
—
—
0
0
87
852
1.04
0.06
4.0
3.8
0.00
0.00
estimate
-0.00
12
178
19
202
0.93
0.05
6.1
6.7
7.42
7.43
ph
0.09
11
122
11
100
1.11
0.05
1.6
2.0
—
—
—
0
0
12
110
1.10
0.05
1.0
1.2
—
—
—
0
0
37
358
1.04
0.04
1.7
1.7
423.72
437.76
pmol/l
0.10
32
293
10
109
0.91
0.04
5.9
5.3
24.57
24.23
mmol/l
—
10
104
64
629
1.02
0.03
2.5
2.1
—
—
—
0
0
13
138
0.94
0.02
1.3
1.6
—
—
—
0
0
155
1542
1.02
0.01
5.5
5.0
6.00
6.03
mmol/l
0.07
142
1403
31
317
0.97
0.01
5.9
5.8
—
—
—
0
0
11
114
0.96
0.00
1.2
1.5
—
—
—
0
0
10
99
1.01
0.00
2.1
4.2
24.59
24.36
mmol/l
—
10
99
13
133
0.98
0.00
2.4
2.5
0.21
0.47
e6/l
0.73
13
126
12
123
0.97
0.00
4.9
4.9
1.60
0.61
%
—
5
41
13
127
1.03
0.00
3.9
5.3
0.40
0.08
%
—
5
37
44
445
0.99
0.00
1.3
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
31.04
—
0
5
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
0.00
—
0
5
0
5
0.00
0.00
0.0
1.0
—
7.36
—
0
5
0
7
0.00
-0.00
0.0
6.0
—
55.29
—
0
7
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
6.36
—
0
7
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
128.67
—
0
6
0
6
0.00
-0.00
0.0
2.0
—
8.90
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
999.57
—
0
7
0
9
0.00
-0.00
0.0
2.3
—
37.82
—
0
9
146
1460
1.00
-0.00
4.7
4.2
1.32
1.25
mmol/l
0.61
137
1322
0
8
0.00
-0.00
0.0
1.3
—
7.10
—
0
8
0
8
0.00
-0.00
0.0
1.3
—
206.22
—
0
8

Mortality – FinRegistry

Association

Association between endpoint M13_ANKYLOSISJOINT and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
M13_ANKYLOSISJOINT 1.198 [0.89, 1.62] 0.241
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 285 males with M13_ANKYLOSISJOINT died.

Mortality risk

Mortality risk for people of age

years, who have M13_ANKYLOSISJOINT.

N-year risk Females Males
1 No data 0.302%
5 No data 1.378%
10 No data 3.297%
15 No data 5.964%
20 No data 10.437%

Relationships between endpoints

Index endpoint: M13_ANKYLOSISJOINT – Ankylosis of joint

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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