cardiomyopathy: A disease of the heart muscle or myocardium proper. Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
308 |
4. Check minimum number of eventsNone |
308 |
5. Include endpointsNone |
308 |
6. Filter based on genotype QC (FinnGen only) |
267 |
Control definitions (FinnGen only)
- Control exclude
- I9_OTHHEART
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Cardiomyopathies, Secondary/extrinsic
based on the number of shared cases.
Similar with more cases:
- Cardiomyopathy (excluding other)
- Cardiomyopathy
- Other heart diseases
- Other heart diseases, wide
- Cardiovascular diseases (excluding rheumatic etc)
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4781 | 746 | 3926 |
| Only index persons | 2094 | 381 | 1713 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.02 | 0.11 |
| Only index persons | 0.06 | 0.01 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 56.51 | 59.10 | 55.87 |
| Only index persons | 58.60 | 60.45 | 58.19 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 267 | 72 | 195 |
| Unadjusted period prevalence (%) | 0.07 | 0.03 | 0.09 |
| Median age at first event (years) | 60.70 | 57.22 | 61.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 272
- Matched controls
- 2720
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I50.9
ICD-10 Finland
Heart failure, unspecified
172.9
237.6
118
12
I42.6
ICD-10 Finland
Alcoholic cardiomyopathy
+∞
227.2
185
*
201
Kela drug reimbursment
Chronic cardiac insufficiency
148.6
214.4
108
12
I48
ICD-10 Finland
Atrial fibrillation and flutter
104.7
173.5
91
13
C01AA05
ATC
digoxin; systemic
55.1
119.5
70
17
I42.0
ICD-10 Finland
Dilated cardiomyopathy
+∞
116.2
103
*
C03DA01
ATC
spironolactone; oral
17.8
107.8
105
93
I42.7
ICD-10 Finland
Cardiomyopathy due to drugs and other external agents
+∞
88.5
80
*
I50.1
ICD-10 Finland
Left ventricular failure
1063.7
83.1
77
*
C03CA01
ATC
furosemide; systemic
9.1
76.0
154
342
I50.0
ICD-10 Finland
Congestive heart failure
828.5
68.1
64
*
207
Kela drug reimbursment
Chronic arrhythmias
761.8
63.5
60
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
8.9
61.5
97
159
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
52.9
49
*
B01AA03
ATC
warfarin; systemic
8.4
50.1
78
124
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
8.6
49.6
75
115
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
+∞
49.5
46
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
48.4
45
*
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
174.1
43.2
44
*
C07AB07
ATC
bisoprolol; oral
5.6
43.1
179
693
289
Kela drug reimbursment
Combination product containing sacubitril and valsartan
+∞
34.1
32
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
5.4
33.9
85
211
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
9.1
33.8
45
58
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.2
30.9
79
198
TFP20
NOMESCO Finland
Cardiodefibrillation
+∞
30.8
29
*
C09DX04
ATC
valsartan and sacubitril; oral
+∞
30.8
29
*
C09AA05
ATC
ramipril; oral
4.3
30.4
116
398
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
174.2
30.3
31
*
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
324.9
29.4
29
*
381
Kela drug reimbursment
Combination product containing sacubitril and valsartan
+∞
28.6
27
*
B01AF02
ATC
apixaban; oral
9.3
28.0
36
44
P15
ICPC
Chronic alcohol abuse
8.5
27.5
38
51
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
9.1
26.2
34
42
I47.2
ICD-10 Finland
Ventricular tachycardia
286.3
26.2
26
*
K78
ICPC
Atrial fibrillation/flutter
25.7
26.0
36
16
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
4.2
25.6
90
286
250, ,
Kela drug reimbursment
+∞
25.4
24
*
K70.0
ICD-10 Finland
Alcoholic fatty liver
53.8
24.8
29
6
XF400
NOMESCO Finland
ECG with 12 standard connections
4.4
23.9
74
213
N07BB01
ATC
disulfiram; oral
6.6
23.0
40
69
C01BD01
ATC
amiodarone; systemic
125.1
21.9
23
*
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
119.2
20.9
22
*
I48.1
ICD-10 Finland
Persistent atrial fibrillation
+∞
20.0
19
*
F10.25
ICD-10 Finland
Alcohol dependence continuous use
16.3
20.0
32
22
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
113.4
19.9
21
*
XF404
NOMESCO Finland
Ambulatory ECG
8.2
19.5
27
36
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
6.2
18.7
34
61
F10.0
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Acute intoxication
20.4
17.7
26
14
K77
ICPC
Heart failure
53.7
17.2
20
*
I48.2
ICD-10 Finland
Chronic atrial fibrillation
180.6
16.7
17
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.5
16.5
71
252
F10.20
ICD-10 Finland
Alcohol dependence currently independent
7.6
16.4
24
34
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
169.3
15.6
16
*
GD1LA
NOMESCO Finland
GD
169.3
15.6
16
*
WX892
NOMESCO Finland
Monitored bed care
5.2
15.4
34
73
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
17.8
15.1
23
14
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
14.4
15.0
25
19
AN1
HP
Coronary angiography
4.2
14.9
44
120
I50
ICD-10 Finland
Heart failure
84.8
14.7
16
*
TPH07
NOMESCO Finland
Cathetrisation of artery
3.9
14.0
46
135
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
15.8
13.8
22
15
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
79.2
13.7
15
*
I44.7
ICD-10 Finland
Left bundle-branch block, unspecified
79.2
13.7
15
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
147.0
13.6
14
*
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
13.1
13.4
23
19
N17.9
ICD-10 Finland
Acute renal failure, unspecified
6.6
13.1
22
36
F10.24
ICD-10 Finland
Alcohol depence active use
12.4
13.1
23
20
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
21.3
12.6
18
9
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
+∞
12.6
12
*
I42.8
ICD-10 Finland
Other cardiomyopathies
+∞
12.6
12
*
N05AA02
ATC
levomepromazine; systemic
5.8
12.5
24
45
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
12.4
146
862
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
11.8
93
453
T36
ICD-10 Finland
Poisoning by systemic antibiotics
6.1
11.7
21
37
ZX120
NOMESCO Finland
Intravenous
3.6
11.5
42
132
F10.09
ICD-10 Finland
Alcohol intoxication UNS
9.2
11.3
23
27
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
13.7
10.8
18
14
N05CD07
ATC
temazepam; oral
3.2
10.6
46
161
R99
ICD-10 Finland
Other ill-defined and unspecified causes of mortality
8.3
10.6
23
30
FPG96
NOMESCO Finland
Other implantation of permanent cardioverter-defibrillator
+∞
10.5
10
*
I42.2
ICD-10 Finland
Other hypertrophic cardiomyopathy
+∞
10.5
10
*
M04AA01
ATC
allopurinol; systemic
3.0
10.4
53
204
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
8.4
10.3
22
28
I47.1
ICD-10 Finland
Supraventricular tachycardia
41.7
10.0
12
*
ZXD05
NOMESCO Finland
Urgent procedure
2.4
9.8
87
443
A10BK01
ATC
dapagliflozin; oral
3.7
9.7
33
99
R06.0
ICD-10 Finland
Dyspnoea
2.5
9.6
79
388
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.1
9.5
27
71
1CX08, ,
NOMESCO Finland
103.5
9.5
10
*
L03AA02
ATC
filgrastim; parenteral
5.0
9.5
21
45
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
+∞
9.4
9
*
FPG32
NOMESCO Finland
Implantation of cardioverter-defibrillator with atrial and ventricular electrodes
+∞
9.4
9
*
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
+∞
9.4
9
*
FPE37
NOMESCO Finland
Implantation of biventricular cardioverter-defibrillator with atrial and ventricular electrodes
+∞
9.4
9
*
I44.2
ICD-10 Finland
Atrioventricular block, complete
+∞
9.4
9
*
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
+∞
9.4
9
*
Z2221
NOMESCO Finland
Medical doctor
2.4
9.2
83
423
N05BA01
ATC
diazepam; systemic, rectal
2.9
9.1
46
176
PH1AC
NOMESCO Finland
Flebography of over extremity with X-ray
38.1
9.1
11
*
N05CF01
ATC
zopiclone; oral
2.3
9.0
100
557
Z3231
NOMESCO Finland
Registered nurse
2.3
9.0
87
457
C07AA07
ATC
sotalol; systemic
14.7
8.8
14
10
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
28.5
8.5
11
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
5.1
8.5
18
37
FPE96
NOMESCO Finland
Other implantation or replacement of transvenous cardiac pacemaker
+∞
8.4
8
*
4258A
ICD-9 Finland
Cardiomyopathy in other diseases classified elsewhere
+∞
8.4
8
*
FPJ24
NOMESCO Finland
Revision of biventricular cardioverter-defibrillator with atrial and ventricular electrodes
+∞
8.4
8
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.6
8.3
20
46
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.0
8.3
39
143
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
15.1
8.3
13
9
A98
ICPC
Health maint/preventive medicine
0.4
8.3
193
2309
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
8.6
8.2
17
21
K70.4
ICD-10 Finland
Alcoholic hepatic failure
34.5
8.1
10
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
4.9
8.0
18
39
JN4BD
NOMESCO Finland
Extensive body CT
2.8
7.9
42
165
N05BA02
ATC
chlordiazepoxide; systemic
6.7
7.9
19
30
A12BA01
ATC
potassium chloride; oral
6.7
7.9
19
30
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
46.3
7.8
9
*
Z2446
NOMESCO Finland
Social worker
3.4
7.5
28
89
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.6
7.3
45
190
I42
ICD-10 Finland
Cardiomyopathy
+∞
7.3
7
*
42792
ICD-8 Finland
Symptomatic heart disease, Fibrillatio auricularis
+∞
7.3
7
*
K70.1
ICD-10 Finland
Alcoholic hepatitis
16.3
7.3
11
7
N05BA04
ATC
oxazepam; oral
2.2
7.1
78
426
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
10.4
7.1
13
13
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
4.2
7.0
19
48
XF640, ,
NOMESCO Finland
11.3
6.9
12
11
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
6.8
49
224
R4110
NOMESCO Finland
Physiotherapy
2.1
6.8
83
473
J01FF01
ATC
clindamycin; systemic
2.1
6.7
74
404
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.8
6.7
21
59
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
8.1
6.7
14
18
Z72.1
ICD-10 Finland
Alcohol use
10.4
6.6
12
12
127
Kela drug reimbursment
Transplant complication
10.4
6.6
12
12
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
6.5
6.6
16
26
R50.9
ICD-10 Finland
Fever, unspecified
2.4
6.5
47
214
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.3
6.5
25
81
V03AA01, ,
ATC
7.7
6.5
14
19
N06AB04
ATC
citalopram; systemic
2.2
6.4
60
306
C07AB02
ATC
metoprolol; systemic
2.3
6.4
52
251
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
3.9
6.3
19
52
I42.1
ICD-10 Finland
Obstructive hypertrophic cardiomyopathy
+∞
6.3
6
*
K86.0
ICD-10 Finland
Alcohol-induced chronic pancreatitis
+∞
6.3
6
*
2000B
ICD-9 Finland
Lymphosarcoma and reticulosarcoma, Reticulosarcoma[LYMPHOMA MALIGNUM DIFFUSUM]
+∞
6.3
6
*
I49.0
ICD-10 Finland
Ventricular fibrillation and flutter
+∞
6.3
6
*
TFJ02
NOMESCO Finland
Muscle biopsy of heart
+∞
6.3
6
*
FJA10
NOMESCO Finland
Transvenous biopsy of right ventricle
+∞
6.3
6
*
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
5.6
6.3
17
32
I35.0
ICD-10 Finland
Aortic (valve) stenosis
27.4
6.3
8
*
S82.6
ICD-10 Finland
Fracture of lateral malleolus
3.5
6.1
21
63
I49.3
ICD-10 Finland
Ventricular premature depolarization
8.9
6.1
12
14
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
8.9
6.1
12
14
R02
ICPC
Shortness of breath/dyspnoea
2.6
6.0
37
156
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
47
110
4.96
19.41
9.3
4.5
24.24
24.48
mmol/l
0.19
47
110
63
197
3.86
17.76
8.7
3.7
2.19
1.88
mmol/l
0.23
58
171
65
213
3.70
17.07
20.6
6.4
0.94
0.56
mmol/l
0.20
54
174
101
500
2.62
12.48
2.8
2.0
2.62
2.86
mg/l
0.47
89
426
43
131
3.71
12.38
29.0
7.8
0.55
0.64
%
0.96
43
131
194
2378
0.36
12.21
53.9
21.1
4.28
4.57
e12/l
10.09
189
2311
194
2377
0.36
12.14
54.1
21.1
225.46
245.10
e9/l
3.26
189
2320
44
139
3.58
12.00
28.5
7.5
93.78
93.85
%
0.03
44
139
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
23
44
5.62
11.76
13.6
2.7
0.37
0.30
iu/ml
0.48
13
21
60
240
2.92
11.05
2.2
1.7
—
—
—
0
0
62
254
2.87
10.92
2.2
1.7
—
—
—
0
0
169
2177
0.41
10.88
5.3
5.1
4.45
4.60
mmol/l
0.99
151
2024
168
2168
0.41
10.81
5.2
5.1
1.32
1.41
mmol/l
1.67
150
1998
175
2209
0.42
10.14
6.1
5.8
2.53
2.72
mmol/l
2.04
158
2039
73
340
2.57
9.94
2.5
1.8
—
—
—
0
0
40
134
3.33
9.91
3.7
2.1
7.77
5.89
ug/l
0.25
40
119
68
309
2.60
9.72
3.6
2.0
2.12
1.56
%
2.02
59
274
192
2311
0.42
8.78
23.4
11.6
33.39
27.89
u/l
2.73
187
2244
62
292
2.45
8.11
25.7
6.4
101.81
104.05
mmol/l
2.08
62
292
52
227
2.60
7.96
2.3
3.0
0.21
0.22
g/l
0.05
46
217
50
217
2.60
7.74
3.3
2.2
30.29
34.30
u/l
0.30
42
187
32
110
3.16
7.57
1.6
1.3
—
—
—
0
0
30
101
3.21
7.34
7.1
3.5
1.55
1.29
%
0.51
30
101
56
1017
0.43
7.28
3.6
4.4
20.19
21.56
%
0.31
22
507
52
239
2.45
7.12
14.7
5.5
236.92
248.74
u/l
0.31
52
228
35
132
2.90
7.06
2.1
1.4
—
—
—
0
0
167
2073
0.50
6.93
4.8
4.3
1.57
1.35
mmol/l
2.54
145
1897
18
44
4.31
6.93
5.3
4.0
4.11
3.88
mmol/l
0.81
18
44
17
40
4.47
6.85
1.2
1.4
—
—
—
0
0
55
264
2.36
6.83
4.4
3.7
14.06
7.76
umol/l
0.73
47
242
29
100
3.13
6.82
7.2
3.5
0.67
0.66
%
0.11
29
100
79
1243
0.49
6.72
3.8
5.2
1.91
2.49
ug/l
0.73
66
1131
160
1148
1.96
6.71
14.1
7.3
13.38
11.79
umol/l
1.05
154
1094
18
34
5.59
6.59
1.4
1.3
—
—
—
0
0
18
34
5.59
6.59
1.4
1.3
—
—
—
0
0
18
46
4.12
6.55
1.9
1.8
—
—
—
0
0
32
120
2.89
6.52
3.2
1.7
0.53
0.32
mg/l
1.12
25
60
138
955
1.90
6.32
18.6
5.4
1.17
1.21
mmol/l
5.96
133
883
20
58
3.64
6.14
4.9
4.6
2.02
1.57
mmol/l
0.37
20
58
101
640
1.92
5.98
3.5
3.0
0.98
0.52
e6/l
0.61
80
453
130
896
1.86
5.92
3.8
2.6
211.95
176.48
ug/l
0.63
121
826
178
2127
0.53
5.57
5.8
5.1
6.41
6.04
mmol/l
1.78
161
1940
179
2135
0.53
5.56
36.6
13.6
79.89
81.25
ml/min/173m2
0.33
173
1964
31
127
2.63
5.35
1.9
1.6
—
—
—
0
0
12
18
6.92
5.31
1.2
1.5
197.08
392.17
u/l
1.06
12
18
176
2100
0.54
5.23
7.0
6.4
41.54
39.69
mmol/mol
1.21
154
1960
107
715
1.82
5.22
4.3
3.9
48.92
32.23
u/l
2.46
101
683
27
106
2.72
5.06
40.4
8.7
15.86
15.97
%
0.08
27
101
12
20
6.22
4.97
1.3
1.5
6.52
5.65
mmol/l
0.32
12
20
15
33
4.75
4.95
1.1
1.4
—
—
—
0
0
15
42
3.72
4.84
1.4
1.3
—
—
—
0
0
76
466
1.88
4.83
7.5
1.8
1.87
1.40
mg/l
0.45
63
372
143
1071
1.71
4.50
17.1
6.2
1.18
1.21
mmol/l
4.30
123
927
60
943
0.53
4.45
2.0
2.0
1.81
1.38
mmol/l
1.92
51
791
17
56
3.17
4.32
1.4
1.5
—
—
—
0
0
67
410
1.84
4.23
3.4
2.8
1.09
1.19
e6/l
0.07
42
223
45
763
0.51
4.21
2.2
3.1
0.56
0.75
ug/l
1.17
34
485
24
102
2.48
3.86
8.6
6.1
23.77
24.48
mmol/l
0.34
24
97
14
39
3.73
3.76
1.9
1.7
—
—
—
0
0
13
34
3.96
3.74
1.2
1.4
—
—
—
0
0
77
512
1.70
3.62
4.1
2.4
—
—
—
0
0
17
66
2.68
3.28
1.5
1.2
—
—
—
0
0
188
2131
0.62
3.17
39.9
13.8
28.46
25.82
mg/l
0.61
177
1722
12
35
3.54
3.15
2.1
2.4
4.45
4.98
kpa
1.26
12
35
19
80
2.48
3.14
1.6
2.5
—
—
—
0
0
7
12
5.95
3.04
3.1
1.6
—
—
—
0
0
7
12
5.95
3.04
2.1
1.6
—
—
—
0
0
7
12
5.95
3.04
2.1
1.6
—
—
—
0
0
7
12
5.95
3.04
2.1
1.6
—
—
—
0
0
10
27
3.80
2.91
1.0
1.4
—
—
—
0
0
10
28
3.67
2.81
2.0
2.1
—
—
—
0
0
82
588
1.56
2.77
3.7
2.7
396.48
352.86
umol/l
1.77
77
507
8
19
4.30
2.70
1.3
1.6
—
—
—
0
0
9
24
3.84
2.69
5.2
3.0
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
5
7
7.25
2.56
2.4
1.0
228.40
152.29
%
—
5
7
92
691
1.50
2.48
4.8
2.7
54.94
65.87
u/l
0.80
86
643
150
1241
1.47
2.48
14.3
10.5
4.49
4.14
e9/l
0.92
133
1091
42
630
0.61
2.34
3.8
2.8
0.00
0.00
estimate
-0.00
15
181
13
53
2.53
2.31
1.5
1.2
—
—
—
0
0
6
13
4.69
2.28
2.7
3.0
—
—
—
0
0
97
1215
0.69
2.28
3.3
2.8
—
—
—
0
0
56
385
1.57
2.24
3.6
2.9
1.62
1.18
e6/l
0.18
30
200
65
876
0.66
2.22
5.2
3.2
0.00
0.01
estimate
0.50
17
192
7
19
3.75
2.16
1.6
1.1
77.43
93.00
%
—
7
19
34
212
1.69
2.00
4.6
3.1
—
—
—
0
0
6
16
3.81
1.94
2.0
1.3
—
—
—
0
0
6
17
3.58
1.84
2.3
4.6
104.00
94.88
%
—
6
17
12
53
2.32
1.83
1.9
1.8
3929.14
22767.18
e6/l
—
7
33
7
23
3.10
1.81
1.4
1.4
—
—
—
0
0
174
1931
0.73
1.72
5.4
4.5
2.07
1.96
mu/l
0.56
160
1724
92
733
1.39
1.72
5.2
3.6
2.33
2.35
mmol/l
0.71
84
660
101
819
1.37
1.70
6.3
2.8
31.93
35.43
ng/l
0.21
85
598
17
92
1.90
1.60
3.5
4.0
4.21
4.77
pmol/l
1.21
17
78
57
430
1.41
1.45
4.3
2.9
2.46
2.45
mmol/l
0.34
51
388
78
625
1.35
1.38
1.8
1.6
17.81
20.22
nmol/l
0.92
70
515
5
17
2.98
1.36
1.0
1.1
—
—
—
0
0
49
639
0.72
1.31
5.6
3.2
0.00
0.00
estimate
0.50
17
204
116
992
1.30
1.29
4.1
2.7
—
—
estimate
—
0
0
47
355
1.39
1.20
2.1
1.7
1151.39
1094.57
nmol/l
0.12
37
262
6
26
2.34
1.19
1.0
1.0
—
—
—
0
0
29
200
1.50
1.18
3.7
2.4
427.86
376.24
nmol/l
1.11
29
191
5
20
2.53
1.15
1.8
1.9
—
—
—
0
0
7
30
2.37
1.13
1.6
1.1
—
—
—
0
0
5
21
2.41
1.09
1.2
1.7
—
—
—
0
0
21
310
0.65
1.09
2.6
2.3
9.93
14.44
nmol/l
1.49
21
287
21
310
0.65
1.09
2.0
1.5
—
—
—
0
0
12
69
1.77
0.98
1.0
3.6
1.25
2.49
ratio
—
6
44
6
27
2.25
0.94
1.0
1.1
—
—
—
0
0
138
1519
0.81
0.92
4.5
3.6
14.98
14.77
pmol/l
0.39
128
1353
181
1675
1.24
0.91
15.8
8.4
90.32
81.81
u/l
1.29
174
1587
5
105
0.47
0.90
1.0
1.0
—
—
—
0
0
10
56
1.82
0.89
1.6
1.6
—
—
—
0
0
23
171
1.38
0.68
1.7
1.5
—
—
—
0
0
19
258
0.72
0.67
23.2
5.4
—
—
—
0
0
20
147
1.39
0.64
8.9
2.7
4.95
5.10
kpa
0.34
20
140
105
1156
0.85
0.62
4.3
3.4
0.00
0.00
estimate
-0.00
17
207
14
197
0.69
0.61
2.4
2.4
0.24
0.28
e6/l
0.11
14
190
8
52
1.55
0.60
2.6
2.9
—
—
—
0
0
0
22
0.00
0.59
0.0
1.5
—
927.51
—
0
17
0
22
0.00
0.59
0.0
1.0
—
502.60
—
0
10
0
22
0.00
0.59
0.0
1.5
—
—
—
0
0
0
22
0.00
0.59
0.0
1.1
—
36.20
—
0
10
7
111
0.62
0.59
3.7
3.6
139.21
1846.20
u/ml
—
7
97
105
1151
0.86
0.58
4.3
3.3
0.00
7.12
estimate
0.50
18
228
10
65
1.56
0.56
2.0
1.2
—
—
—
0
0
10
65
1.56
0.56
1.2
1.2
—
—
—
0
0
10
65
1.56
0.56
2.0
1.2
—
—
—
0
0
19
143
1.35
0.54
4.5
3.0
54.43
68.07
ml/min/173m2
—
7
60
104
1135
0.86
0.53
4.3
3.3
0.00
0.00
estimate
-0.00
18
223
9
65
1.40
0.51
1.1
1.4
—
—
—
0
0
7
45
1.57
0.49
2.7
2.9
—
—
—
0
0
8
56
1.44
0.43
2.0
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
5
34
1.48
0.40
1.0
1.1
1.56
1.43
g/l
—
5
29
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
2.8
—
4.27
—
0
11
152
1597
0.89
0.40
4.9
4.1
17.99
11.19
mm/h
3.60
142
1473
5
36
1.40
0.38
1.0
2.3
7.96
7.81
pmol/l
—
5
36
43
489
0.86
0.38
5.7
3.5
1.02
1.02
kg/l
0.08
35
326
12
91
1.33
0.34
1.9
1.3
—
—
—
0
0
10
75
1.35
0.30
3.6
1.8
—
—
—
0
0
12
150
0.79
0.27
2.7
2.2
—
—
—
0
0
11
139
0.78
0.27
2.7
2.0
—
—
—
0
0
5
72
0.69
0.26
3.0
1.3
—
—
—
0
0
5
38
1.32
0.23
1.0
1.1
—
—
—
0
0
75
797
0.92
0.22
4.2
3.9
8.92
4.43
mg/mmol
0.85
57
505
0
11
0.00
0.21
0.0
1.2
—
10.64
—
0
11
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
86.53
—
0
10
0
12
0.00
0.21
0.0
1.3
—
1.03
—
0
5
0
12
0.00
0.21
0.0
2.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
1.28
—
0
5
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
0.85
—
0
5
19
164
1.17
0.21
3.9
3.9
1.18
1.23
mmol/l
1.92
19
147
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
53.77
—
0
9
6
53
1.13
0.19
1.5
1.7
—
—
—
0
0
6
53
1.13
0.19
1.0
1.0
—
3.77
—
0
6
99
950
1.07
0.17
2.6
2.3
71.56
76.19
nmol/l
0.67
90
852
8
70
1.15
0.16
2.6
1.7
—
—
—
0
0
10
83
1.21
0.15
13.8
2.6
24.72
24.74
mmol/l
—
10
77
32
345
0.92
0.13
1.1
1.3
9.89
12.98
u/ml
—
9
123
34
363
0.93
0.12
1.1
1.3
23.37
31.21
iu/ml
0.32
12
113
150
1471
1.04
0.11
6.0
3.6
112.67
58.15
u/l
4.49
142
1388
6
56
1.07
0.08
1.2
1.1
—
—
—
0
0
105
1027
1.04
0.08
2.2
2.0
84.47
94.80
pmol/l
1.54
65
540
44
457
0.96
0.07
1.2
1.2
2.95
1.71
u/ml
—
6
119
16
149
1.08
0.05
1.4
1.5
—
—
—
0
0
45
448
1.01
0.00
2.0
1.7
459.88
26005774.15
pmol/l
0.79
32
373
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
0.35
—
0
6
9
96
0.94
-0.00
2.3
1.8
181.33
216.49
pmol/l
—
9
91
0
5
0.00
-0.00
0.0
1.4
—
7.36
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
1369.22
—
0
9
0
8
0.00
-0.00
0.0
1.5
—
41.30
—
0
8
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
72.10
—
0
5
0
7
0.00
-0.00
0.0
1.4
—
31.92
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint I9_CARDMSEC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMSEC | 6.432 [4.18, 9.9] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.206 |
During the follow-up period (1.1.1998 — 31.12.2019), 110 out of 233 females with I9_CARDMSEC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMSEC | 7.233 [5.83, 8.98] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 480 out of 782 males with I9_CARDMSEC died.
Mortality risk
Mortality risk for people of age
years, who have I9_CARDMSEC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.612% | 1.675% |
| 5 | 3.985% | 8.275% |
| 10 | 9.404% | 18.906% |
| 15 | 17.163% | 33.051% |
| 20 | 27.778% | 49.542% |
Relationships between endpoints
↥Index endpoint: I9_CARDMSEC – Cardiomyopathies, Secondary/extrinsic
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data