Cardiomyopathy due to drugs and other external agents

CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — I42.7# 1 out of 7 registries used, show all original rules.	89
4. Check minimum number of events None	89
5. Include endpoints None	89
6. Filter based on genotype QC (FinnGen only)	75

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	I427
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Cardiomyopathy due to drugs and other external agents based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	370	194	172
Only index persons	288	154	134
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	58.64	60.72	56.11
Only index persons	57.79	60.94	54.16

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	75	50	25
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	61.47	58.57	67.27

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
76: Matched controls
760

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

I42.7

ICD-10 Finland

Cardiomyopathy due to drugs and other external agents

+∞

109.3

I50.1

ICD-10 Finland

Left ventricular failure

43.5

56.2

201

Kela drug reimbursment

Chronic cardiac insufficiency

29.0

48.0

117

Kela drug reimbursment

Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue

18.4

31.1

I42.0

ICD-10 Finland

Dilated cardiomyopathy

57.3

30.3

I50.9

ICD-10 Finland

Heart failure, unspecified

11.5

26.1

C03DA01

ATC

spironolactone; oral

11.3

25.2

C09AA05

ATC

ramipril; oral

7.9

18.6

135

C03CA01

ATC

furosemide; systemic

7.5

16.7

171

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

7.1

16.3

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

6.3

14.7

142

I42.9

ICD-10 Finland

Cardiomyopathy, unspecified

38.5

14.7

I50.0

ICD-10 Finland

Congestive heart failure

13.7

14.1

H02AB02

ATC

dexamethasone; systemic

6.5

13.3

C09DX04

ATC

valsartan and sacubitril; oral

56.3

12.3

I47.2

ICD-10 Finland

Ventricular tachycardia

19.2

12.0

AN1

Coronary angiography

7.3

11.9

289

Kela drug reimbursment

Combination product containing sacubitril and valsartan

42.2

11.7

XFP20

NOMESCO Finland

Check up of cardiac pacemaker

13.1

11.4

C83.31

ICD-10 Finland

Diffuse lymphoma with large B cells

51.5

11.3

L03AA02

ATC

filgrastim; parenteral

13.5

10.5

C07AB07

ATC

bisoprolol; oral

5.8

10.2

299

GD1AA

NOMESCO Finland

Thorax X-ray examination

5.2

10.1

265

115

Kela drug reimbursment

Breast cancer

5.9

10.1

A03FA01

ATC

metoclopramide; systemic, rectal

4.6

9.9

136

250, ,

Kela drug reimbursment

21.0

9.8

381

Kela drug reimbursment

Combination product containing sacubitril and valsartan

35.0

9.7

PJD52

NOMESCO Finland

Block dissection of axillary lymph nodes

13.2

9.3

FN1AC

NOMESCO Finland

Angiography of heart and/or coronary arteries

4.4

9.0

119

C01AA05

ATC

digoxin; systemic

9.0

FM1DE

NOMESCO Finland

Doppler ultrasound examination of heart

5.7

8.7

N02AA05

ATC

oxycodone; systemic

4.4

8.6

8500/3-C50.9

ICD-O-3

Infiltrating duct carcinoma, NOS, of breast, NOS

8.8

8.0

A49.9

ICD-10 Finland

Bacterial infection, unspecified

5.0

7.7

C85.9

ICD-10 Finland

Non-Hodgkin lymphoma, unspecified

88.4

7.6

Z95.0

ICD-10 Finland

Presence of electronic cardiac devices

9.5

7.5

Z45.0

ICD-10 Finland

Adjustment and management of cardiac devices

12.7

7.1

127

Kela drug reimbursment

Transplant complication

44.2

6.9

JN4BD

NOMESCO Finland

Extensive body CT

4.4

6.7

TFC00

NOMESCO Finland

Catheterisation of right atrium or ventricle

76.0

6.5

L04AA01

ATC

[U] ciclosporin

+∞

6.3

207

Kela drug reimbursment

Chronic arrhythmias

4.1

6.3

J01MA12

ATC

levofloxacin; systemic

3.6

6.3

100

L03AA13

ATC

pegfilgrastim; parenteral

6.6

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

7.24

12.74

4.0

3.2

417.83

163.65

ng/l

1.19

(3023368) Bacteria identified in Blood by Culture

188

4.18

8.76

5.1

4.4

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

169

4.10

8.54

2.3

2.2

2.69

3.07

mg/l

0.45

151

(3012095) Magnesium [Moles/volume] in Serum or Plasma

112

3.77

6.97

7.3

2.8

0.80

0.81

mmol/l

0.18

104

(3001122) Ferritin [Mass/volume] in Serum or Plasma

312

3.52

6.03

3.3

3.1

204.04

104.17

ug/l

1.49

289

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

112

3.38

5.71

3.0

2.2

—

(3019977) pH of Arterial blood

3.57

5.70

4.5

8.0

7.45

7.42

0.65

(3045788) Cell count panel - Pleural fluid

14.67

5.20

1.9

1.0

—

(3001604) Monocytes [#/volume] in Blood

360

3.33

5.11

10.7

5.9

0.59

0.55

e9/l

0.59

313

(3003396) Base excess in Arterial blood by calculation

3.36

5.06

4.6

8.0

1.63

1.29

mmol/l

0.16

(3006315) Basophils [#/volume] in Blood

362

3.30

5.02

10.8

5.9

0.04

e9/l

0.50

313

(3013115) Eosinophils [#/volume] in Blood

370

3.16

4.68

11.0

6.0

0.15

0.18

e9/l

1.74

328

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.15

4.46

2.4

2.1

—

(3012441) Differential panel - Pleural fluid

12.66

4.36

1.7

1.3

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

5.27

4.27

2.0

2.1

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

338

2.71

3.96

11.1

7.9

1.21

mmol/l

0.08

296

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

3.49

3.94

3.6

2.6

7.45

4.32

ug/l

0.26

(3036782) Glucose [Moles/volume] in Pleural fluid

9.48

3.86

1.3

1.1

6.97

6.09

mmol/l

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

209

2.50

3.72

2.5

2.2

121.05

150.21

u/l

0.36

196

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

5.07

3.57

1.1

2.0

—

(40768806) Pleura Pathology biopsy report

10.71

3.56

2.0

1.5

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.75

3.55

6.5

7.7

103.91

103.87

mmol/l

0.01

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

164

2.50

3.55

3.6

2.4

—

(3030467) Casts [#/volume] in Urine by Automated count

188

2.46

3.54

3.7

3.1

0.20

0.37

e6/l

0.99

133

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.84

3.52

2.4

2.2

—

(42870588) Differential panel, method unspecified - Blood

222

2.42

3.50

10.1

5.4

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

4.63

3.33

1.1

2.1

—

(4035726) Immunohistochemistry procedure

2.83

3.27

1.4

1.3

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

8.02

3.11

1.3

221.50

293.79

u/l

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

3.20

3.10

4.8

8.8

0.48

0.70

1.58

(3021589) Normoblasts [#/volume] in Blood

313

2.31

3.09

13.7

12.3

0.00

e9/l

0.80

252

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.07

3.09

2.4

1.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

241

2.27

3.05

4.9

3.1

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

106

2.51

3.01

3.7

3.0

1.82

1.18

e6/l

0.17

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

316

2.28

2.98

3.8

2.8

—

estimate

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.72

2.95

1.5

1.2

—

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

7.12

2.92

3.5

1.9

—

(3042936) Bacteria identified in Isolate by Culture

111

2.38

2.71

3.0

2.0

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.93

2.69

1.4

1.5

—

(3022313) Gas panel - Capillary blood

3.94

2.67

3.8

2.3

—

(3032080) INR in Blood by Coagulation assay

335

2.17

2.66

23.9

14.4

1.46

1.22

inr

1.57

277

(3002582) Erythrocytes [#/volume] in Urine

225

2.14

2.65

4.0

3.3

20.42

25.62

e6/l

0.21

172

(3000991) Gas panel - Venous blood

2.78

2.63

10.6

8.6

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

2.98

2.59

2.6

3.7

3.99

4.48

pmol/l

0.87

(21494815) CD4 cells/Lymphocytes in Specimen

7.54

2.59

4.2

1.4

32.10

27.16

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

4.13

2.54

5.5

5.2

40.50

52.83

u/ml

—

(3044640) Blood type and Crossmatch panel - Blood

221

2.08

2.47

4.1

2.5

—

(3018418) pH of Serum or Plasma

221

2.08

2.47

7.4

5.2

7.39

7.40

0.25

163

(3016650) Hepatitis A virus Ab [Presence] in Serum

5.32

2.45

1.2

1.1

—

(3002256) Pathology report gross observation

2.40

2.41

1.6

1.3

—

(3045142) Bone marrow Pathology biopsy report

6.59

2.41

2.2

1.4

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

3.76

2.34

2.0

2.1

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

3.76

2.34

3.9

2.1

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.78

2.32

4.3

8.6

1.23

1.69

0.90

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

4.17

2.31

1.0

2.1

—

(3018095) Leukocytes [#/volume] in Urine

253

2.00

2.28

4.6

3.8

151.77

44.02

e6/l

0.39

175

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

3.60

2.25

1.1

2.0

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.04

2.23

3.0

7.7

25.36

24.98

mmol/l

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.26

2.23

1.4

3.0

—

(3020891) Body temperature

3.05

2.08

6.8

4.8

36.79

37.03

°c

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

278

1.93

2.06

6.0

4.1

33.18

33.83

ng/l

0.02

197

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

3.56

2.02

2.9

1.8

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

3.98

1.97

2.5

2.0

—

(40761535) Cells panel - Urine sediment

2.45

1.97

6.4

3.6

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

3.40

1.93

1.4

1.3

—

(3043409) Potassium [Moles/volume] in Arterial blood

3.40

1.93

3.0

3.9

4.19

3.87

mmol/l

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.78

1.87

2.1

1.9

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

4.38

1.85

1.6

1.2

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.24

1.85

1.6

1.1

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

4.04

1.74

1.2

1.1

—

(3019060) Gas panel - Arterial blood

2.46

1.73

2.5

4.5

—

(3026008) Bacteria identified in Urine by Culture

217

1.82

1.71

4.0

3.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.19

1.67

2.6

1.6

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.74

1.64

2.2

1.4

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

3.74

1.64

1.6

1.2

—

(3000850) Epithelial cells [#/volume] in Urine

167

1.85

1.64

3.2

2.8

6.72

5.12

e6/l

0.38

149

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

1.58

0.0

1.0

—

(40768443) Skin Pathology biopsy report

2.75

1.55

1.0

1.3

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.01

1.54

1.8

1.4

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.87

1.46

1.2

1.1

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.87

1.46

1.0

1.1

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

2.87

1.46

1.2

2.3

94.67

89.36

—

(40760892) CBC W Ordered Manual Differential panel - Blood

173

1.76

1.44

6.8

6.1

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

2.24

1.36

9.0

3.4

24.12

24.48

mmol/l

—

(3005719) IgG [Mass/volume] in Serum or Plasma

2.00

1.29

2.4

2.1

9.26

10.44

g/l

0.47

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

103

1.84

1.26

1.4

1.6

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.30

1.26

6.8

3.1

0.68

0.64

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

2.74

1.23

1.2

2.3

3.14

3.53

g/l

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.17

1.19

7.1

3.0

1.57

1.42

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

2.12

1.16

3.5

2.3

1.20

2.28

mmol/l

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

1.79

1.07

4.4

3.1

3.00

4.88

e6/l

—

(40758558) Short blood count panel - Blood

235

1.54

0.99

15.8

6.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

111

1.68

0.98

1.9

2.0

—

(1761868) Lipid panel - Serum or Plasma

252

0.63

0.92

2.9

3.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.81

0.0

2.4

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.81

0.0

1.2

—

300.68

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

650

0.63

0.76

5.8

5.4

4.68

mmol/l

0.00

595

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.16

0.76

1.2

1.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.64

0.75

1.2

1.5

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

664

0.64

0.67

6.8

6.1

2.70

2.73

mmol/l

0.08

607

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

646

0.66

0.65

5.6

5.3

1.39

1.51

mmol/l

1.39

585

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.77

0.65

2.0

2.6

—

(3031040) Bacteria [#/volume] in Urine by Automated count

451

1.40

0.63

6.4

4.6

—

43.80

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.63

0.63

1.9

1.4

—

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

0.61

0.0

1.2

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.61

0.0

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

707

0.64

0.61

54.5

26.0

38.60

40.05

1.74

695

(3000963) Hemoglobin [Mass/volume] in Blood

707

0.64

0.61

54.1

25.8

126.10

133.94

g/l

3.83

696

(3035941) MCH [Entitic mass]

707

0.64

0.61

53.5

25.5

30.27

30.32

0.08

695

(3026361) Erythrocytes [#/volume] in Blood

707

0.64

0.61

53.8

25.6

4.21

4.44

e12/l

3.15

687

(3007461) Platelets [#/volume] in Blood

707

0.64

0.61

54.1

25.6

237.44

251.39

e9/l

0.90

692

(3010813) Leukocytes [#/volume] in Blood

707

0.64

0.61

53.9

25.7

6.75

6.52

e9/l

0.41

687

(3024731) MCV [Entitic mean volume] in Red Blood Cells

707

0.64

0.61

53.6

25.6

92.13

91.15

1.23

695

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

152

1.43

0.60

1.7

1.8

477.14

473.42

pmol/l

0.02

125

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.59

0.60

6.5

3.4

—

(40768804) Tissue Pathology biopsy report

285

1.35

0.58

2.9

2.1

—

(3000494) Fungus identified in Specimen by Culture

1.50

0.55

2.3

1.6

—

(3003694) ABO and Rh group [Type] in Blood

175

1.36

0.51

1.6

1.4

—

(3021440) Promyelocytes/Leukocytes in Blood

1.54

0.50

7.8

5.2

0.00

0.25

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

1.50

0.48

1.4

1.1

—

166.93

—

(3025159) Blasts/Leukocytes in Blood

1.49

0.44

6.5

5.7

0.00

0.05

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.41

0.0

1.1

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.41

0.0

1.2

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.41

0.0

1.4

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.41

0.0

1.3

—

(3008898) HLA-B27 [Presence]

0.00

0.41

0.0

1.3

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.41

0.0

6.2

—

25.82

—

(3020682) Albumin/Creatinine [Ratio] in Urine

252

0.77

0.40

4.4

3.9

1.98

6.44

mg/mmol

1.64

157

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.40

0.0

2.8

—

12.43

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.39

0.0

1.9

—

4.10

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

551

1.32

0.39

38.2

21.3

14.24

13.73

2.60

541

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.39

0.35

1.5

1.3

—

(3017181) Myelocytes/Leukocytes in Blood

1.38

0.32

7.8

4.9

0.40

0.85

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

305

1.21

0.29

2.2

2.1

90.80

96.39

pmol/l

0.25

146

(40768797) Stomach Pathology biopsy report

106

1.27

0.25

1.6

1.3

—

(3015736) pH of Urine

299

1.18

0.25

6.0

3.7

6.71

6.26

1.41

168

(3012516) Albumin [Mass/volume] in Urine

249

0.84

0.23

4.3

3.2

13.65

37.50

mg/l

1.37

159

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.30

0.23

2.0

2.1

—

(3021601) Nitrite [Presence] in Urine by Test strip

371

1.17

0.22

5.5

4.0

0.00

estimate

—

(40768800) Prostate Pathology biopsy report

0.00

0.21

0.0

1.3

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.21

0.0

1.2

—

(3026782) Osmolality of Urine

137

1.21

0.21

4.4

2.9

551.19

527.90

mosm/kgh2o

0.17

119

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

613

0.83

0.20

5.3

4.5

1.53

1.27

mmol/l

1.37

556

(3025941) Bacteria identified in Stool by Culture

1.22

0.20

1.3

—

(40761536) Microorganisms panel - Urine sediment

1.19

0.20

4.2

—

(3035350) Ketones [Presence] in Urine by Test strip

373

1.15

0.20

5.6

4.1

0.00

estimate

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

121

0.80

0.19

1.8

1.7

—

(3045414) Leukocytes [Presence] in Urine

0.73

0.17

2.8

2.2

—

0.00

estimate

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

691

0.85

0.17

51.2

21.9

84.91

76.41

umol/l

1.27

682

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

641

1.23

0.17

32.5

16.4

74.11

79.72

ml/min/173m2

1.15

599

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

121

1.19

0.16

1.1

1.3

1.10

13.12

u/ml

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

460

0.90

0.13

3.9

3.4

99.26

48.64

u/l

1.00

429

(3009261) Glucose [Presence] in Urine by Test strip

381

1.11

0.11

5.6

4.1

0.00

estimate

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.16

0.09

1.5

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.08

0.09

6.3

5.4

1.19

1.23

mmol/l

—

(3000492) Spirometry study

0.79

0.08

2.3

1.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.10

0.07

19.9

7.5

—

(40761511) CBC panel - Blood by Automated count

677

0.91

0.07

26.2

15.0

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

671

1.13

0.07

45.1

19.9

4.09

3.97

mmol/l

3.77

655

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

138

1.11

0.07

1.1

1.3

17.10

35.46

iu/ml

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

283

0.93

0.06

6.5

4.0

0.00

0.02

estimate

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

388

1.07

0.05

3.0

3.3

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

629

0.92

0.04

7.5

6.8

42.09

39.90

mmol/mol

0.84

583

(3007164) IgA [Mass/volume] in Serum or Plasma

162

1.06

0.02

1.1

1.4

2.17

2.30

g/l

—

(3029937) Albumin [Presence] in Urine by Test strip

207

1.02

0.00

7.5

4.3

0.00

estimate

—

(3013512) EKG study

255

0.97

0.00

7.2

3.6

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.98

0.00

3.0

2.2

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.3

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

6.4

—

1.14

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.4

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.1

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.6

—

4.52

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.8

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

-0.00

0.0

1.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.90

-0.00

1.2

2.4

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

-0.00

0.0

1.1

—

(3022145) Colonoscopy Study observation

0.89

-0.00

1.4

1.3

—

(3020876) Protein [Mass/time] in 24 hour Urine

0.00

-0.00

0.0

4.0

—

0.68

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.2

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

(4062490) Immunoglobulin typing, IgG

0.00

-0.00

0.0

1.3

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

-0.00

0.0

1.0

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

672

1.11

-0.00

45.2

19.7

139.18

139.68

mmol/l

0.75

657

(3026470) Cobalt [Mass/volume] in Blood

0.00

-0.00

0.0

2.2

—

3.47

—

(3025577) Chromium [Mass/volume] in Blood

0.00

-0.00

0.0

2.3

—

2.25

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

-0.00

0.0

1.3

—

(3036432) Mycobacterium tuberculosis genotype [Identifier] in Isolate

0.00

-0.00

0.0

9.8

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.3

—

(44806071) Cardiolipin IgM antibody measurement

0.00

-0.00

0.0

1.2

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

-0.00

0.0

1.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.02

-0.00

2.2

1.5

—

(3014271) Vancomycin [Susceptibility]

0.00

-0.00

0.0

2.2

—

(4211845) Urine protein measurement

0.00

-0.00

0.0

1.5

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.2

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.6

—

9.90

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.92

-0.00

3.2

2.5

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

-0.00

0.0

1.0

—

(3006462) Nitrate [Presence] in Urine

0.00

-0.00

0.0

1.6

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

-0.00

0.0

1.1

—

(3044927) Protein electrophoresis panel - Urine

0.00

-0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS and mortality.

Females

Parameter	HR [95% CI]	p-value
CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS	5.804 [3.29, 10.24]	< 0.001
Birth year	0.991 [0.98, 1.0]	0.04

During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 160 females with CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS died.

Males

Parameter	HR [95% CI]	p-value
CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS	4.335 [2.25, 8.34]	< 0.001
Birth year	0.991 [0.98, 1.0]	0.118

During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 136 males with CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS died.

Mortality risk

Mortality risk for people of age

years, who have CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS.

N-year risk	Females	Males
1	0.329%	0.929%
5	2.531%	5.604%
10	7.054%	13.748%
15	13.192%	25.687%
20	21.35%	40.197%

Relationships between endpoints

↥

Index endpoint: CARDIOMYOPATHY_DRUGS_OTHER_EXTER_AGENTS – Cardiomyopathy due to drugs and other external agents

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Cardiomyopathy due to drugs and other external agents

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints