eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
1127 |
6. Filter based on genotype QC (FinnGen only) |
997 |
Control definitions (FinnGen only)
- Control exclude
- H7_VITREOUS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorders of globe
based on the number of shared cases.
Similar with more cases:
- Disorders of vitreous body and globe
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9948 | 5247 | 4600 |
| Only index persons | 7619 | 4160 | 3459 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.15 | 0.13 |
| Only index persons | 0.14 | 0.15 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 66.32 | 70.47 | 61.57 |
| Only index persons | 63.06 | 68.34 | 56.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 997 | 538 | 459 |
| Unadjusted period prevalence (%) | 0.20 | 0.19 | 0.21 |
| Median age at first event (years) | 64.04 | 63.51 | 64.67 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1030
- Matched controls
- 10300
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H44.2
ICD-10 Finland
Degenerative myopia
3179.1
278.0
256
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
13.2
260.3
284
289
H44.0
ICD-10 Finland
Purulent endophthalmitis
+∞
238.0
219
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
25.3
226.9
165
77
WX140
NOMESCO Finland
Parabulbar anesthesy
12.0
201.6
227
238
S01ED51
ATC
timolol, combinations; ophthalmic
8.6
198.1
307
484
H44.1
ICD-10 Finland
Other endophthalmitis
+∞
190.7
177
*
H44.5
ICD-10 Finland
Degenerated conditions of globe
+∞
188.5
175
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
43.2
173.9
105
27
Z96.1
ICD-10 Finland
Presence of intraocular lens
6.0
168.9
432
1110
S01ED01
ATC
timolol; ophthalmic
11.6
168.6
189
195
CKA10
NOMESCO Finland
Biopsy of vitreous body
1750.0
156.4
148
*
S01EC01
ATC
acetazolamide; systemic
14.9
147.9
138
106
S01EA05
ATC
brimonidine; ophthalmic
13.2
133.2
133
114
114
Kela drug reimbursment
Glaucoma
6.0
132.7
289
628
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
6.2
131.4
271
559
H33.0
ICD-10 Finland
Retinal detachment with retinal break
12.3
129.5
136
126
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
10.8
127.0
147
157
H43.8
ICD-10 Finland
Other disorders of vitreous body
15.9
122.8
109
76
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.7
120.2
272
608
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
4.0
103.7
612
2772
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.2
97.7
352
1127
H52.1
ICD-10 Finland
Myopia
10.1
96.0
114
125
H20.1
ICD-10 Finland
Chronic iridocyclitis
29.1
93.5
63
23
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
14.8
89.6
82
60
S01EE01
ATC
latanoprost; ophthalmic
5.5
87.7
194
418
H26.4
ICD-10 Finland
After-cataract
4.5
86.9
261
723
XCK00
NOMESCO Finland
Perimetry
6.0
83.7
165
319
H43.1
ICD-10 Finland
Vitreous haemorrhage
228.3
82.6
84
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.6
79.7
224
587
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
29.4
78.9
53
19
H26.2
ICD-10 Finland
Complicated cataract
18.8
77.2
62
35
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
5.7
77.1
158
316
S01EA03
ATC
apraclonidine; ophthalmic
18.3
72.7
59
34
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
32.1
70.5
46
15
S01EX03, ,
ATC
9.0
69.9
90
109
XCK10
NOMESCO Finland
Photography of fundus of eye
4.4
69.9
208
566
S01EC04
ATC
brinzolamide; ophthalmic
6.2
69.5
129
234
CKD40
NOMESCO Finland
Endophotocoagulation of retina
16.0
67.9
59
39
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.1
67.7
570
2967
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
5.2
61.6
138
297
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
13.7
60.1
57
44
WX142
NOMESCO Finland
Sub-tenon anesthesy
17.5
56.8
47
28
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
5.0
56.8
134
301
S01EC03
ATC
dorzolamide; ophthalmic
10.9
56.6
62
60
H44.4
ICD-10 Finland
Hypotony of eye
+∞
55.7
53
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.7
53.8
596
3446
S01BA07
ATC
fluorometholone; ophthalmic
10.7
53.3
59
58
S01BA04
ATC
prednisolone; ophthalmic
8.0
51.5
72
96
CKC12
NOMESCO Finland
Photocoagulation of retina
6.8
50.6
83
132
XCH00
NOMESCO Finland
Eye pressure measurement
4.9
49.8
117
261
S01FA01
ATC
atropine; ophthalmic
19.3
49.3
39
21
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
6.2
48.6
86
148
S01BC03
ATC
diclofenac; ophthalmic
8.1
48.5
67
88
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
5.9
47.4
89
162
S01BA01
ATC
dexamethasone; ophthalmic
5.9
47.0
88
160
H26.02
ICD-10 Finland
Presenil cataract
7.4
46.7
70
101
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
14.0
46.2
43
32
H16.0
ICD-10 Finland
Corneal ulcer
5.0
45.6
104
226
WX100
NOMESCO Finland
Conjunctival surface anesthesia
3.1
45.4
231
878
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
11.4
44.5
47
43
S01EC54
ATC
brinzolamide, combinations; ophthalmic
10.1
44.2
51
53
S01EB01
ATC
pilocarpine; ophthalmic
13.7
43.6
41
31
S01EE05
ATC
tafluprost; ophthalmic
5.2
43.4
94
195
Z3229
NOMESCO Finland
Other healthcare associate professional
3.6
43.2
158
489
S01EE03
ATC
bimatoprost; ophthalmic
6.5
43.0
72
117
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
12.1
42.3
43
37
H25.1
ICD-10 Finland
Senile nuclear cataract
2.4
41.4
455
2528
H44.8
ICD-10 Finland
Other disorders of globe
413.0
40.4
40
*
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
145.8
40.0
42
*
H40.0
ICD-10 Finland
Glaucoma suspect
3.5
39.0
149
473
XCD10
NOMESCO Finland
Electrophysiological examination of eye
6.3
38.4
66
110
S01EE04
ATC
travoprost; ophthalmic
6.3
35.8
62
104
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
4.8
35.6
83
183
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
6.5
34.6
58
94
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
7.2
34.6
52
75
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
7.5
32.9
48
67
TCH12
NOMESCO Finland
Sample aspiration from anterior chambre
+∞
32.5
31
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
6.0
32.4
59
104
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
3.3
30.3
127
425
XCD20
NOMESCO Finland
Photoangiography of eye
7.0
29.9
46
68
ZXA00
NOMESCO Finland
Right side
2.2
29.7
353
1968
CHC05
NOMESCO Finland
Iridotomy
7.2
28.6
43
62
H40.9
ICD-10 Finland
Glaucoma, unspecified
5.6
28.3
55
103
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
11.0
27.9
30
28
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
102.9
27.8
30
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
6.6
27.5
45
71
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
6.6
27.1
44
69
H54.4
ICD-10 Finland
Blindness, monocular
42.5
26.9
33
8
H57.1
ICD-10 Finland
Ocular pain
4.4
26.4
68
162
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
4.2
25.8
70
174
Z97.0
ICD-10 Finland
Presence of artificial eye
95.9
25.8
28
*
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
6.9
25.6
40
60
WX002
NOMESCO Finland
Sedation and analgesia
2.3
25.5
249
1269
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
6.6
25.3
41
64
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
5.2
24.9
52
104
3643
FHL
Vitrectomy through pars Plana
92.4
24.8
27
*
ZXA05
NOMESCO Finland
Left side
2.1
24.6
313
1768
H33.3
ICD-10 Finland
Retinal breaks without detachment
5.0
24.6
54
113
A10AA01, ,
ATC
5.3
24.5
50
98
H3603, E103,
ICD-10 Finland
35.5
24.4
31
9
CKC10
NOMESCO Finland
Local photocoagulation of retina
6.0
24.2
43
74
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
3.2
23.2
98
328
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
25.3
23.2
32
13
H44.3
ICD-10 Finland
Other degenerative disorders of globe
+∞
23.0
22
*
S01BC05
ATC
ketorolac; ophthalmic
3.5
23.0
83
252
CHF15
NOMESCO Finland
Cryotherapy of ciliary body
235.0
22.7
23
*
H16.9
ICD-10 Finland
Keratitis, unspecified
6.5
22.4
37
59
CKD15
NOMESCO Finland
Injection of vitreous substitute
28.0
22.3
30
11
A10AB01
ATC
insulin (human); parenteral
4.3
22.0
59
145
A10AA02, ,
ATC
4.0
22.0
65
172
ZXA10
NOMESCO Finland
Bilateral
2.1
21.4
240
1284
H04.10
ICD-10 Finland
Dry eye syndrome
2.5
21.4
149
651
XCW10
NOMESCO Finland
Assessment of vision
5.8
21.3
39
69
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
30.8
20.6
27
9
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
4.0
20.2
58
150
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
27.7
20.1
27
10
CKD20
NOMESCO Finland
Removal of vitreous body substitute
19.3
20.0
30
16
H44.9
ICD-10 Finland
Disorder of globe, unspecified
+∞
19.9
19
*
3600A
ICD-9 Finland
Disorders of the globe, Purulent endophthalmitis
+∞
19.9
19
*
H44.6
ICD-10 Finland
Retained (old) intraocular foreign body, magnetic
+∞
19.9
19
*
CHD99
NOMESCO Finland
Other filtering operation
29.6
19.7
26
9
Z94.7
ICD-10 Finland
Corneal transplant status
25.1
19.6
27
11
S01ED02
ATC
betaxolol; ophthalmic
6.6
19.3
31
48
CKC20
NOMESCO Finland
Cryopexy of undetached retina
23.1
19.1
27
12
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
20.5
19.1
28
14
S01AX11
ATC
[U] ofloxacin
3.5
18.8
65
192
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
14.5
18.7
31
22
H54.1
ICD-10 Finland
Severe visual impairment, binocular
101.9
18.6
20
*
CS494
NOMESCO Finland
Other visual field testing
4.4
18.5
47
111
CKD60
NOMESCO Finland
Anterior vitrectomy
7.3
18.3
27
38
S01EA02
ATC
dipivefrine; ophthalmic
19.8
18.3
27
14
H33.5
ICD-10 Finland
Other retinal detachments
22.2
18.2
26
12
127
Kela drug reimbursment
Transplant complication
7.1
17.9
27
39
H21.0
ICD-10 Finland
Hyphaema
23.3
17.8
25
11
CDC00
NOMESCO Finland
Enucleation of eye
67.8
17.8
20
*
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
14.2
17.3
29
21
ZXD05
NOMESCO Finland
Urgent procedure
1.8
17.2
327
2076
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
4.2
16.9
45
110
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
3.5
16.8
58
171
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
15.4
16.7
27
18
3608A
ICD-9 Finland
Disorders of the globe, Other disorders of globe[ANOPHTALMIA ARTEFACTA]
+∞
16.7
16
*
37861
ICD-8 Finland
Other diseases of eye, Phthisis et degeneratio bulbi
+∞
16.7
16
*
3602A
ICD-9 Finland
Disorders of the globe, Degenerative disorders of globe[MYOPIA MALIGNA]
+∞
16.7
16
*
37520
ICD-8 Finland
Glaucoma, Secondary
91.6
16.6
18
*
TCK20
NOMESCO Finland
Needle biopsy of vitreous body
91.6
16.6
18
*
S01FA04
ATC
cyclopentolate; ophthalmic
7.1
16.6
25
36
H18.1
ICD-10 Finland
Bullous keratopathy
28.1
16.5
22
8
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
172.7
16.5
17
*
H25.0
ICD-10 Finland
Senile incipient cataract
2.7
16.4
94
372
CFD10
NOMESCO Finland
Repair of conjunctiva
40.8
16.4
20
5
A10AB04
ATC
insulin lispro; parenteral
4.1
16.3
45
113
H54.0
ICD-10 Finland
Blindness, binocular
48.3
16.1
19
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
14.8
15.9
26
18
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
4.2
15.8
43
107
3745
FHL
Hard membrane girding, cerclage with coagulation
61.0
15.8
18
*
3641A
ICD-9 Finland
Disorders of iris and ciliary body, Chronic iridocyclitis
+∞
15.7
15
*
TCA15
NOMESCO Finland
Retrobulbar therapeutic injection into orbit
162.4
15.5
16
*
L04AA01
ATC
[U] ciclosporin
6.8
15.4
24
36
H02AB06
ATC
prednisolone; systemic
1.7
15.3
502
3697
CFW99
NOMESCO Finland
Other operation on conjunctiva
23.8
15.1
21
9
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
4.9
15.0
33
69
TCG10
NOMESCO Finland
Removal of sutures from cornea
16.8
14.8
23
14
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
21.4
14.7
21
10
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
2.6
14.7
87
350
H35.36
ICD-10 Finland
Macular cyst
12.1
14.6
26
22
36609
ICD-8 Finland
Other inflammation of uveal tract, Unspecified
+∞
14.6
14
*
H04AA01
ATC
glucagon; nasal, parenteral
5.0
14.6
31
63
CGF10
NOMESCO Finland
Suture of laceration of cornea
152.1
14.5
15
*
3661A
ICD-9 Finland
Cataract, Senile cataract
4.4
14.2
36
85
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
16.0
14.0
22
14
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.1
14.0
147
759
CKC65
NOMESCO Finland
Removal of buckling implant from sclera
54.1
13.8
16
*
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
54.1
13.8
16
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
13.8
13.8
23
17
H27.0
ICD-10 Finland
Aphakia
15.0
13.6
22
15
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
34.5
13.5
17
5
H21.1
ICD-10 Finland
Other vascular disorders of iris and ciliary body
141.8
13.5
14
*
H35.4
ICD-10 Finland
Peripheral retinal degeneration
11.7
13.3
24
21
CM2X4
NOMESCO Finland
Follow-up OCT of age-related macular degeneration lesions
10.6
13.3
25
24
H35.6
ICD-10 Finland
Retinal haemorrhage
9.8
13.3
26
27
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
40.6
13.2
16
*
CKC30
NOMESCO Finland
Cryopexy of detached retina
12.4
13.1
23
19
25002
ICD-8 Finland
Diabetes mellitus, Retinopathia diabetica
50.7
12.9
15
*
H3603, E113,
ICD-10 Finland
11.7
12.8
23
20
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
5.9
12.8
23
40
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
3.5
12.7
43
125
CHD35
NOMESCO Finland
Laser goniopuncture
15.7
12.6
20
13
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
12.5
12.6
22
18
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
12.5
12.6
22
18
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
12.5
12.6
22
18
H33.4
ICD-10 Finland
Traction detachment of retina
32.5
12.6
16
5
36402
ICD-8 Finland
Iritis, Iridocyclitis, uveitis chronica
32.5
12.6
16
5
H30.2
ICD-10 Finland
Posterior cyclitis
32.5
12.6
16
5
3656X
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUCOMA SECUNDARIA ALIA SEU NUD]
+∞
12.5
12
*
H44.7
ICD-10 Finland
Retained (old) intraocular foreign body, nonmagnetic
+∞
12.5
12
*
CKC15
NOMESCO Finland
Panretinal photocoagulation
10.2
12.5
24
24
S01FA02
ATC
scopolamine; ophthalmic
9.5
12.5
25
27
H05.0
ICD-10 Finland
Acute inflammation of orbit
131.6
12.5
13
*
H01.0
ICD-10 Finland
Blepharitis
2.6
12.4
76
311
Z3231
NOMESCO Finland
Registered nurse
1.7
12.3
285
1886
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
3.9
12.3
36
95
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
12.2
244
1549
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
3.3
12.0
45
140
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
47.2
11.9
14
*
CM2S4
NOMESCO Finland
Follow-up photography of age-related macular degeneration lesions
11.9
11.9
21
18
H53.1
ICD-10 Finland
Subjective visual disturbances
2.5
11.7
76
320
3708
FHL
Trabeculectomy or equivalent
30.4
11.7
15
5
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
8.7
11.6
24
28
H40.11
ICD-10 Finland
Low pressure glaucoma
3.7
11.5
37
104
CKC60
NOMESCO Finland
Local buckling of sclera using implant
10.2
11.5
22
22
H20.8
ICD-10 Finland
Other iridocyclitis
13.8
11.5
19
14
37514
ICD-8 Finland
Glaucoma, Chronicum absolutum s. fero absolutum dolorosum
+∞
11.5
11
*
3711
FHL
Cyclodiateria or cryocoagulation
+∞
11.5
11
*
ZXE00
NOMESCO Finland
One hour or less
1.6
11.4
384
2784
A10AB05
ATC
insulin aspart; parenteral
2.3
11.4
92
426
CK2M4
NOMESCO Finland
Macular light layer imaging (OCT)
8.4
11.3
24
29
ZX198
NOMESCO Finland
Other local administration
8.4
11.3
24
29
3660C
ICD-9 Finland
Cataract, Infantile, juvenile and presenile cataract[CATARACTA PRAESENILIS]
17.3
11.2
17
10
37872
ICD-8 Finland
Other diseases of eye, Aphakia artefacta, acquisita
43.8
10.9
13
*
A10AD01
ATC
insulin (human); parenteral
3.8
10.9
33
89
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.7
10.9
34
94
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
15.7
10.8
17
11
A12AA04
ATC
calcium carbonate; oral
4.5
10.8
26
59
3663A
ICD-9 Finland
Cataract secondary to ocular disorders
28.3
10.7
14
5
CFB00
NOMESCO Finland
Suture of conjunctiva
28.3
10.7
14
5
37510
ICD-8 Finland
Glaucoma, Chronicum simplex
21.7
10.7
15
7
H40.3
ICD-10 Finland
Glaucoma secondary to eye trauma
21.7
10.7
15
7
A10AC01
ATC
insulin (human); parenteral
2.2
10.6
96
466
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
10.6
379
2777
S01AD03
ATC
aciclovir; ophthalmic
2.9
10.5
50
180
3747
FHL
Combined ablation and vitreous surgery with coagulation
111.1
10.4
11
*
3604
FHL
Penetration of the cornea
111.1
10.4
11
*
CDC40
NOMESCO Finland
Evisceration of eye with insertion of prosthesis
111.1
10.4
11
*
3604A
ICD-9 Finland
Disorders of the globe, Degenerated conditions of globe
+∞
10.4
10
*
CAE10
NOMESCO Finland
Revision and secondary implant in orbit
+∞
10.4
10
*
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
5.5
10.4
20
37
H35.8
ICD-10 Finland
Other specified retinal disorders
12.2
10.4
18
15
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
10.7
10.3
19
18
37002
ICD-8 Finland
Refractive errors, Myopia
23.6
10.3
14
6
S01AA01
ATC
chloramphenicol; ophthalmic
2.6
10.2
60
241
H40.8
ICD-10 Finland
Other glaucoma
12.3
9.9
17
14
H3600, E113,
ICD-10 Finland
5.2
9.9
20
39
ZXD20
NOMESCO Finland
Day surgery
1.9
9.8
133
748
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.2
9.8
83
393
S05.6
ICD-10 Finland
Penetrating wound of eyeball without foreign body
55.5
9.7
11
*
XCH05
NOMESCO Finland
Eye pressure longterm registration
4.9
9.6
21
44
H53.0
ICD-10 Finland
Amblyopia ex anopsia
9.2
9.5
19
21
H43.3
ICD-10 Finland
Other vitreous opacities
15.2
9.5
15
10
CAW99
NOMESCO Finland
Other operation on orbit
100.9
9.4
10
*
3102
FHL
Enucleation
100.9
9.4
10
*
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
7.0
9.3
22
32
ZYC01
NOMESCO Finland
Remote contact by phone
2.4
9.3
64
277
CG2T4
NOMESCO Finland
Topography assessment of cornea
7.4
9.2
21
29
H40.20
ICD-10 Finland
Acute glaucoma with closed ventricular angle
10.1
9.0
17
17
37600
ICD-8 Finland
Detachment of retina, Primaria
37.0
9.0
11
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.5
9.0
353
2621
T89
ICPC
Diabetes insulin dependent
2.7
8.9
46
173
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
2.2
8.7
75
357
Z94.0
ICD-10 Finland
Kidney transplant status
7.7
8.7
19
25
Z49.1
ICD-10 Finland
Extracorporeal dialysis
4.4
8.6
21
48
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
8.6
167
1045
CKD95
NOMESCO Finland
Extended combined vitectomy and lens procedure through pars plana
11.7
8.6
15
13
H53.9
ICD-10 Finland
Visual disturbance, unspecified
2.9
8.5
40
143
E913A
ICD-9 Finland
Accidental mechanical suffocation
90.8
8.4
9
*
H3603, E107,
ICD-10 Finland
90.8
8.4
9
*
TK800
NOMESCO Finland
Hemodialysis
3.5
8.4
28
81
3852
FHL
Reoperation for another reason
+∞
8.3
8
*
CKC70
NOMESCO Finland
Circular buckling of sclera
10.9
8.3
15
14
H27.1
ICD-10 Finland
Dislocation of lens
10.9
8.3
15
14
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
9.5
8.3
16
17
L04AA06
ATC
mycophenolic acid; systemic
4.0
8.2
23
59
S05.1
ICD-10 Finland
Contusion of eyeball and orbital tissues
4.4
8.2
20
46
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
17.3
8.1
12
7
S01AX12
ATC
[U] norfloxacin
9.0
8.1
16
18
SPAT1301
SPAT
No procedures
1.5
8.0
304
2233
V03AE01
ATC
polystyrene sulfonate; oral
4.0
7.9
22
56
CHD00
NOMESCO Finland
Laser trabeculoplasty
4.0
7.9
22
56
H35.9
ICD-10 Finland
Retinal disorder, unspecified
13.1
7.9
13
10
ZXC20
NOMESCO Finland
Use of chemical agents
3.2
7.9
31
100
R42
ICD-10 Finland
Dizziness and giddiness
1.6
7.8
241
1689
H26.3
ICD-10 Finland
Drug-induced cataract
10.9
7.8
14
13
A10AE04
ATC
insulin glargine; parenteral
1.9
7.7
105
590
3718X
ICD-9 Finland
Corneal opacity and other disorders of cornea, Other corneal disorders
45.3
7.7
9
*
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
45.3
7.7
9
*
CHW99
NOMESCO Finland
Other operation on anterior chamber, anterior chamber angle, iris or ciliary body
45.3
7.7
9
*
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
7.5
7.7
17
23
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
8.1
7.6
16
20
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
8.1
7.6
16
20
CA1AD
NOMESCO Finland
Orbita CT
25.2
7.6
10
*
H18.6
ICD-10 Finland
Keratoconus
10.1
7.5
14
14
CJE00
NOMESCO Finland
Phakoemulsification
80.7
7.4
8
*
ZZL00
NOMESCO Finland
Free graft of amniotic membrane
80.7
7.4
8
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.8
7.4
111
643
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
7.7
7.4
16
21
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
13.5
7.4
12
9
L01BA01
ATC
methotrexate; systemic
2.7
7.4
38
143
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
2.2
7.4
62
293
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.1
7.4
66
320
36600
ICD-8 Finland
Other inflammation of uveal tract, Abscessus oculi. Uveitis suppurativa. Panophthalmitis
+∞
7.3
7
*
3649
FHL
Other measure in this category
+∞
7.3
7
*
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
7.3
7
*
CBH30
NOMESCO Finland
Tarsorraphy
+∞
7.3
7
*
3700A
ICD-9 Finland
Keratitis, Corneal ulcer
+∞
7.3
7
*
36608
ICD-8 Finland
Other inflammation of uveal tract, Alia definita
+∞
7.3
7
*
H25.8
ICD-10 Finland
Other senile cataract
1.7
7.3
135
832
TCF00
NOMESCO Finland
Subconjunctival therapeutic injection
15.9
7.2
11
7
AA1AD
NOMESCO Finland
CT of head and brain
1.5
7.2
304
2271
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.8
7.2
100
566
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
7.1
235
1667
CJF45
NOMESCO Finland
Removal and implantation of artificial lens in anterior chamber with iridectomy or iridotomy
20.2
7.1
10
5
H36.01
ICD-10 Finland
Diabetic maculopathy
3.8
7.1
21
56
H40
ICD-10 Finland
Glaucoma
4.1
7.1
19
47
S01EE51
ATC
latanoprost and netarsudil; ophthalmic
8.9
7.1
14
16
CK2Y4
NOMESCO Finland
OCT video recording of ocular fundus
10.1
7.0
13
13
A46
ICD-10 Finland
Erysipelas
1.6
7.0
155
1002
A10AE05
ATC
insulin detemir; parenteral
2.2
7.0
56
260
N18.8
ICD-10 Finland
Other chronic renal failure
2.9
6.9
32
114
R3120
NOMESCO Finland
Training in mobility skills
8.3
6.8
14
17
3793C
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[PSEUDOPHAKIA]
11.0
6.8
12
11
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
11.0
6.8
12
11
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
16.8
6.8
10
6
E10
ICD-10 Finland
Type 1 diabetes mellitus
3.5
6.7
22
63
S01AA12
ATC
tobramycin; ophthalmic
7.2
6.7
15
21
B03XA02
ATC
darbepoetin alfa; parenteral
2.9
6.7
30
105
Z49.0
ICD-10 Finland
Preparatory care for dialysis
5.9
6.6
17
29
A11CC03
ATC
alfacalcidol; systemic
3.0
6.6
29
100
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
12.3
6.6
11
9
3744
FHL
Pericardial identification surgery with coagulation (includes epi- and intrascleral indications and eg Lincoff catheter)
12.3
6.6
11
9
A10AE06
ATC
insulin degludec; parenteral
2.6
6.6
38
152
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
3.0
6.6
28
95
Z2446
NOMESCO Finland
Social worker
2.0
6.5
69
357
F99
ICPC
Eye/adnexa disease other
6.2
6.5
16
26
N0830, E102,
ICD-10 Finland
70.3
6.4
7
*
CDC30
NOMESCO Finland
Evisceration of eye
70.3
6.4
7
*
3665A
ICD-9 Finland
Cataract, After-cataract
70.3
6.4
7
*
CK2P4
NOMESCO Finland
Optic nerve head light layer imaging (OCT)
7.5
6.4
14
19
CK9G4
NOMESCO Finland
Iridocyanine green angiography (ICGA) of choroid and retina
14.4
6.4
10
7
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.8
6.4
104
618
H3601, E113,
ICD-10 Finland
3.3
6.3
23
71
H35.37
ICD-10 Finland
Macular holes
3.4
6.3
22
66
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.3
6.3
45
199
CG2S4
NOMESCO Finland
Photography of cornea
9.3
6.3
12
13
3651B
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA CAPSULARE (AVOKULMA)]
9.3
6.3
12
13
CHC03
NOMESCO Finland
Laser iridoplasty
18.1
6.3
9
5
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
18.1
6.3
9
5
CHB05
NOMESCO Finland
Puncture of anterior chamber of eye to lower intraocular pressure
+∞
6.3
6
*
37601
ICD-8 Finland
Detachment of retina, Secundaria
+∞
6.3
6
*
CAE00
NOMESCO Finland
Removal of implant from orbit
+∞
6.3
6
*
CAE20
NOMESCO Finland
Revision of conjunctival sac with graft
+∞
6.3
6
*
CDC10
NOMESCO Finland
Enucleation of eye with insertion of prosthesis
+∞
6.3
6
*
3792A
ICD-9 Finland
Other disorders of eye, Disorders of vitreous body
+∞
6.3
6
*
3620B
ICD-9 Finland
Other retinal disorders, Diabetic retinopathy[RETINOPATHIA DIABETICA PROLIFERATIVA]
+∞
6.3
6
*
CHB99
NOMESCO Finland
Other operation on anterior chamber and anterior chamber angle
26.8
6.2
8
*
CJF20
NOMESCO Finland
Removal of artificial lens
26.8
6.2
8
*
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
5.1
6.2
18
36
A10AA03, ,
ATC
4.0
6.2
17
43
UJF32
NOMESCO Finland
Coloscopy
1.5
6.1
251
1856
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.8
6.1
83
467
V03AE02
ATC
sevelamer; oral
12.6
6.1
10
8
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.9
6.1
77
424
H26.1
ICD-10 Finland
Traumatic cataract
8.7
6.1
12
14
H3601, E103,
ICD-10 Finland
8.7
6.1
12
14
H40.1
ICD-10 Finland
Primary open-angle glaucoma
10.1
6.0
11
11
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
6.1
6.0
15
25
137
Kela drug reimbursment
Uraemia requiring dialysis
6.1
6.0
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
116
260
4.90
49.07
1.7
1.6
—
—
—
0
0
102
206
5.39
48.64
1.8
1.6
—
—
—
0
0
34
80
4.36
13.45
1.5
1.2
—
—
—
0
0
31
78
4.07
11.26
1.1
1.2
—
—
—
0
0
23
47
4.98
10.77
1.3
1.2
—
—
—
0
0
29
74
4.00
10.35
2.3
2.4
16.34
23.68
iu/ml
—
5
13
194
1242
1.69
9.20
9.5
5.2
1.08
1.03
mmol/l
1.01
183
1139
18
37
4.93
8.38
2.5
3.1
503.61
855.68
u/ml
1.55
18
37
43
164
2.69
8.12
9.4
5.2
208.00
367.35
iu/ml
—
10
20
207
1404
1.59
7.72
2.0
2.0
30.14
29.58
s
0.69
199
1362
35
127
2.82
7.28
1.9
1.4
136.67
154.32
au/ml
—
6
36
15
21
7.23
6.71
1.1
1.0
—
—
—
0
0
547
4609
1.40
6.48
10.7
7.0
1.21
1.21
mmol/l
0.35
478
3953
167
1138
1.56
6.02
6.2
7.3
5.16
5.09
kpa
0.30
159
1097
167
1139
1.56
5.99
6.2
7.3
11.74
11.84
kpa
0.09
159
1099
165
1127
1.55
5.88
6.1
7.3
1.69
1.05
mmol/l
0.95
128
923
494
4141
1.37
5.79
9.4
6.3
1.21
1.21
mmol/l
0.57
460
3801
178
1263
1.49
5.29
1.9
1.8
—
—
—
0
0
485
4092
1.35
5.28
6.2
5.0
34.84
35.18
g/l
0.64
444
3832
113
724
1.63
5.27
1.7
1.6
—
—
—
0
0
157
1097
1.51
5.02
3.9
3.9
245.87
257.70
u/l
0.42
146
1039
114
741
1.61
5.02
6.7
3.5
114.19
86.34
ng/l
2.02
94
639
14
28
5.05
4.95
1.1
1.0
2203.36
1646.79
miu/ml
0.85
14
28
461
3899
1.33
4.78
3.0
2.4
75.97
78.12
nmol/l
0.94
408
3467
263
2059
1.37
4.50
5.6
4.4
1.02
1.02
kg/l
0.15
189
1406
350
2871
1.33
4.40
2.4
2.1
208.88
275.42
u/l
0.77
331
2722
421
3549
1.32
4.35
4.8
4.1
69.78
62.76
ng/l
0.08
320
2643
541
4734
1.30
4.19
6.2
6.4
11.19
11.77
umol/l
0.33
520
4505
361
2991
1.32
4.19
4.6
3.5
35.43
82.39
e6/l
1.24
292
2311
400
3363
1.31
4.17
5.7
4.1
149.03
124.47
e6/l
0.15
293
2413
64
377
1.74
4.12
2.0
2.2
38.05
39.07
u/l
0.16
55
329
529
4623
1.30
4.10
5.6
4.2
0.00
3.46
estimate
0.80
117
1012
723
6600
1.32
3.98
9.7
8.1
81.68
80.69
u/l
0.17
694
6232
162
1196
1.42
3.89
1.9
1.9
—
—
—
0
0
357
2982
1.30
3.83
4.8
4.1
15.45
8.91
mg/mmol
1.07
247
1840
520
4562
1.28
3.80
5.4
4.2
0.00
0.00
estimate
-0.00
113
985
580
5161
1.28
3.78
6.8
5.1
7.03
6.76
mmol/l
1.94
567
4919
314
2582
1.31
3.77
4.4
3.4
0.41
0.46
e6/l
0.19
245
1923
42
225
1.90
3.69
2.0
1.3
—
—
—
0
0
118
831
1.47
3.64
2.9
2.9
66.10
66.46
g/l
0.20
107
758
262
2112
1.32
3.61
3.4
2.7
4.12
5.83
e6/l
2.16
244
1925
230
1821
1.34
3.59
4.4
4.2
127.35
331.61
ng/l
2.55
191
1491
527
4653
1.27
3.58
5.6
4.3
0.01
0.33
estimate
0.50
107
953
7
9
7.82
3.56
9.0
5.3
—
—
—
0
0
213
1670
1.35
3.54
2.1
1.9
—
—
—
0
0
135
981
1.43
3.54
8.1
3.4
1.68
1.77
mmol/l
0.10
119
832
270
2194
1.31
3.50
4.8
4.2
89.23
87.85
%
0.39
264
2152
34
174
1.99
3.42
1.7
1.5
18876.29
886.99
e6/l
0.48
28
136
15
53
2.86
3.36
3.1
1.6
150.33
90.94
ng/l
0.94
15
53
91
622
1.51
3.26
6.5
8.5
93.96
93.83
%
0.09
91
617
333
2806
1.28
3.24
3.2
2.6
54.58
61.75
u/l
1.74
313
2601
188
1466
1.35
3.23
4.1
3.2
1.47
2.41
e6/l
1.81
106
732
461
4039
1.26
3.22
2.2
2.2
97.20
94.86
pmol/l
0.48
246
2120
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
13
44
2.98
3.14
1.0
1.2
—
—
—
0
0
33
173
1.94
3.12
1.6
1.4
155.56
21.30
e6/l
0.71
25
131
355
3031
1.26
3.07
4.3
3.4
6.73
7.28
mmol/l
1.69
311
2546
296
2474
1.28
3.05
2.7
2.3
2.88
2.96
mg/l
0.21
264
2115
66
427
1.58
3.03
2.6
1.8
2.31
2.04
ug/l
0.08
58
370
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
53
325
1.66
3.02
2.9
2.6
0.34
0.38
iu/ml
0.23
30
186
11
31
3.58
2.99
1.0
1.1
—
—
—
0
0
112
812
1.43
2.99
2.5
2.4
6.04
6.96
ug/l
0.37
93
706
21
94
2.26
2.98
2.6
2.3
—
—
—
0
0
16
63
2.56
2.96
1.4
1.1
119.62
101.25
pmol/l
1.05
16
63
686
6325
1.25
2.92
4.8
4.3
15.08
14.95
pmol/l
0.64
613
5740
68
449
1.55
2.88
1.8
1.9
1.63
1.56
g/l
0.27
63
401
192
1527
1.32
2.88
3.3
3.1
0.81
0.82
mmol/l
0.27
183
1435
200
1600
1.31
2.87
4.1
3.0
0.98
1.17
e6/l
0.32
120
872
485
4314
1.23
2.85
19.4
16.8
1.32
1.30
inr
0.29
418
3636
96
683
1.45
2.84
2.9
2.8
63.46
64.48
ml/min/173m2
0.08
37
303
135
1021
1.37
2.82
9.3
7.7
—
—
—
0
0
334
2857
1.25
2.79
3.5
3.2
35.31
33.67
u/l
0.26
316
2695
6
10
6.03
2.70
2.7
1.4
—
—
—
0
0
628
5765
1.23
2.64
6.3
5.0
14367.73
2471.69
e6/l
0.63
11
103
187
1499
1.30
2.64
3.8
2.5
2.24
2.29
g/l
0.65
172
1387
353
3063
1.23
2.55
3.5
3.2
2075.04
1538.86
ng/l
1.07
317
2663
707
6588
1.23
2.51
29.1
22.1
13.76
13.77
%
0.08
701
6496
31
173
1.82
2.48
1.5
1.5
—
—
—
0
0
44
273
1.64
2.44
1.4
1.5
0.11
0.09
iu/ml
—
10
47
6
12
5.02
2.40
1.2
1.2
99.00
98.83
%
—
6
12
6
12
5.02
2.40
15.2
12.5
4.88
5.63
mmol/l
—
6
12
113
855
1.36
2.38
7.3
2.9
4.42
4.36
kpa
0.11
113
831
5
8
6.27
2.37
1.4
1.0
—
—
—
0
0
13
52
2.52
2.36
2.5
2.0
—
—
—
0
0
196
1608
1.27
2.31
3.8
2.5
11.98
12.42
umol/l
0.35
182
1493
65
449
1.48
2.28
2.7
3.3
4.30
4.44
pmol/l
0.55
58
393
674
6281
1.21
2.25
5.1
4.4
14.88
13.27
mm/h
1.53
628
5818
172
1394
1.28
2.24
4.0
2.5
20.17
22.07
%
1.47
161
1299
866
8289
1.28
2.23
29.8
21.4
3.98
3.99
mmol/l
0.07
848
8091
84
612
1.41
2.23
6.9
8.4
0.63
0.64
%
0.09
84
607
865
8280
1.28
2.22
29.5
21.2
139.47
139.59
mmol/l
0.62
849
8097
80
581
1.41
2.17
6.3
8.5
24.50
24.34
mmol/l
0.16
75
567
535
4891
1.20
2.16
11.4
9.4
4.40
4.21
e9/l
1.04
476
4238
5
10
5.02
2.07
1.2
1.0
—
—
—
0
0
51
344
1.51
2.03
3.6
3.8
33.85
49.61
mg/l
0.95
45
300
51
344
1.51
2.03
3.6
3.8
48.62
66.63
mg/l
0.48
45
300
34
208
1.66
2.03
2.2
1.9
5.23
31.76
iu/l
0.48
12
85
298
2595
1.21
2.01
5.4
4.3
0.00
0.01
estimate
0.96
105
908
41
265
1.57
1.98
3.7
3.3
3.72
3.96
mmol/l
2.87
41
260
34
210
1.64
1.97
1.5
1.5
—
—
—
0
0
75
551
1.39
1.93
4.9
3.3
2.16
2.09
mmol/l
0.04
57
412
840
8068
1.22
1.75
24.4
17.5
27.20
25.71
mg/l
0.57
713
6745
12
54
2.24
1.74
2.1
2.5
—
—
—
0
0
786
7503
1.20
1.73
6.1
5.4
2.04
1.96
mu/l
0.81
727
6869
24
140
1.73
1.73
1.4
1.2
194.75
271.26
u/ml
0.84
14
70
8
30
2.68
1.72
2.3
1.3
—
—
—
0
0
7
24
2.93
1.72
3.7
2.3
0.55
0.61
mmol/l
—
7
24
5
13
3.86
1.71
1.0
1.2
1.18
1.19
mmol/l
—
5
13
75
563
1.36
1.71
7.5
3.5
23.69
24.22
mmol/l
0.75
75
556
794
7592
1.20
1.69
8.0
6.7
41.30
39.78
mmol/mol
3.73
745
7056
36
236
1.54
1.67
1.7
1.6
—
—
—
0
0
7
25
2.81
1.65
1.0
1.1
—
—
—
0
0
7
25
2.81
1.65
1.0
1.1
—
—
—
0
0
7
25
2.81
1.65
1.0
1.1
—
—
—
0
0
66
491
1.37
1.61
4.9
4.0
1.02
1.02
ratio
0.46
58
454
26
159
1.65
1.60
5.3
1.4
0.86
0.84
nmol/l
0.05
19
133
7
26
2.70
1.58
1.0
1.2
—
—
—
0
0
20
114
1.77
1.57
1.7
1.6
—
—
—
0
0
10
44
2.28
1.56
1.6
1.5
11.96
7.55
u/l
—
5
36
36
241
1.51
1.54
1.6
1.6
—
—
—
0
0
50
359
1.41
1.51
2.0
2.9
1.10
1.11
g/l
0.01
43
311
6
21
2.87
1.50
1.0
1.1
—
—
—
0
0
36
243
1.50
1.49
2.0
1.7
—
—
—
0
0
197
1697
1.20
1.48
1.8
1.8
1263.06
1193.65
nmol/l
0.46
155
1292
21
124
1.71
1.48
5.5
4.8
345.81
359.79
umol/l
0.16
16
111
383
3485
1.16
1.48
5.2
4.3
0.04
0.04
estimate
0.00
82
814
216
1877
1.19
1.47
1.7
1.7
1.20
1.31
mg/l
0.38
169
1478
81
632
1.31
1.46
1.7
1.7
—
—
—
0
0
309
2769
1.17
1.45
1.8
1.8
21.91
20.24
nmol/l
0.71
264
2340
191
1644
1.20
1.45
1.6
1.5
2.59
2.54
g/l
0.12
121
1000
435
4003
1.15
1.42
3.3
2.9
—
—
estimate
—
0
0
879
8523
1.21
1.41
31.2
23.2
84.80
79.85
umol/l
2.24
865
8404
352
3198
1.15
1.37
3.4
3.4
2.34
2.35
mmol/l
1.19
312
2891
24
151
1.60
1.35
1.3
1.5
—
—
—
0
0
56
419
1.36
1.35
2.7
2.6
4.24
4.24
g/l
0.01
50
383
56
419
1.36
1.35
2.7
2.6
4.31
3.67
g/l
0.54
50
383
56
419
1.36
1.35
2.7
2.6
7.60
7.42
g/l
0.34
50
383
46
334
1.39
1.33
5.8
3.7
24.42
25.22
mmol/l
0.58
41
308
25
161
1.57
1.29
1.8
1.7
—
—
—
0
0
35
243
1.46
1.29
4.2
3.2
1.00
1.86
index
0.78
18
124
253
2254
1.16
1.28
3.2
2.7
362.95
349.54
umol/l
1.15
219
1968
27
178
1.53
1.27
2.4
2.8
8.89
9.28
pmol/l
0.08
27
178
8
35
2.30
1.27
1.1
1.1
—
—
—
0
0
52
390
1.35
1.25
2.8
2.6
2.97
2.96
g/l
0.03
44
354
117
1393
0.82
1.24
1.4
1.3
21.51
12.66
u/ml
0.40
42
502
27
179
1.52
1.24
1.3
1.5
—
—
—
0
0
9
45
2.01
1.23
2.8
1.6
14.33
21.32
nmol/l
—
9
38
11
56
1.97
1.22
1.2
1.2
—
—
—
0
0
866
8415
1.18
1.19
15.1
12.4
26.42
25.40
u/l
0.53
843
8147
240
2143
1.16
1.18
3.2
2.5
—
—
—
0
0
10
50
2.01
1.16
1.3
1.2
—
—
—
0
0
47
352
1.35
1.16
3.5
3.0
—
—
—
0
0
209
1850
1.16
1.15
1.3
1.3
2.24
1.53
u/ml
0.28
47
508
42
311
1.37
1.11
2.2
2.7
0.00
0.02
g/l
0.50
37
280
10
51
1.97
1.11
1.3
1.2
—
—
—
0
0
217
1932
1.16
1.11
2.8
2.9
2.45
2.46
mmol/l
0.57
197
1740
5
21
2.39
1.09
1.0
1.2
—
—
—
0
0
41
304
1.36
1.08
2.2
2.7
0.00
0.00
g/l
-0.00
35
266
34
245
1.40
1.06
1.2
1.1
—
—
—
0
0
34
245
1.40
1.06
1.2
1.1
—
—
—
0
0
10
52
1.93
1.06
1.3
1.2
—
—
—
0
0
10
52
1.93
1.06
1.3
1.2
—
—
—
0
0
18
113
1.60
1.06
1.8
1.5
—
—
—
0
0
9
46
1.96
1.03
2.7
1.5
—
—
—
0
0
9
46
1.96
1.03
2.7
1.5
—
—
—
0
0
48
368
1.32
1.03
2.4
2.6
10.40
10.43
g/l
0.01
42
330
33
238
1.40
1.03
1.7
1.6
6880.63
17154.18
e6/l
1.85
19
165
21
138
1.53
1.03
1.4
1.3
—
—
—
0
0
11
60
1.84
1.03
1.4
1.5
—
—
—
0
0
31
222
1.41
1.01
1.4
1.4
—
—
—
0
0
90
749
1.22
1.01
4.8
3.8
1.22
1.23
mmol/l
0.66
74
639
19
123
1.55
1.00
3.6
1.7
31.37
32.50
pg
0.36
19
123
364
3382
1.12
0.96
2.1
1.9
1.41
1.33
mmol/l
1.09
307
2803
29
208
1.41
0.95
2.5
2.4
247.82
96.52
ug/min
0.82
18
125
13
209
0.62
0.94
1.1
1.2
1.59
1.55
g/l
0.24
13
209
6
27
2.23
0.93
1.0
1.2
—
—
—
0
0
100
849
1.20
0.93
3.3
2.3
29.96
35.56
u/l
1.35
80
705
91
1075
0.83
0.92
5.9
4.9
33.33
32.52
%
0.33
63
682
15
94
1.60
0.91
1.3
1.9
—
—
—
0
0
41
315
1.31
0.89
3.9
3.6
4.51
2.65
ratio
0.26
23
188
14
218
0.64
0.89
1.1
1.2
0.93
0.90
g/l
0.13
14
218
6
29
2.08
0.89
3.3
3.0
10.80
9.86
kpa
—
6
29
6
29
2.08
0.89
3.3
3.0
5.26
4.77
kpa
—
6
29
35
263
1.34
0.89
5.9
3.0
1.32
1.59
mmol/l
1.92
35
258
122
1060
1.17
0.88
1.5
1.4
—
—
—
0
0
44
344
1.29
0.86
1.8
2.0
2.99
7.68
iu/ml
1.76
13
84
14
88
1.60
0.84
1.2
1.2
1.33
1.47
nmol/l
0.18
14
79
478
4534
1.10
0.82
2.9
2.8
—
—
—
0
0
11
65
1.70
0.82
1.3
1.2
—
—
—
0
0
885
8670
1.15
0.81
35.6
26.5
91.44
91.40
fl
0.10
876
8544
885
8671
1.15
0.81
35.7
26.6
247.83
247.38
e9/l
0.07
872
8462
8
47
1.71
0.80
1.0
1.0
—
—
—
0
0
885
8673
1.14
0.79
36.2
27.1
39.47
39.80
%
1.00
875
8541
885
8673
1.14
0.79
35.7
26.6
4.38
4.43
e12/l
2.12
866
8437
22
156
1.42
0.79
1.6
1.9
5.47
4.75
mmol/24h
0.35
16
141
415
3916
1.10
0.79
4.0
3.0
128.38
131.98
ug/l
0.12
388
3616
8
48
1.67
0.79
1.6
2.2
—
—
—
0
0
15
98
1.54
0.78
1.7
1.9
—
2022.86
—
0
7
885
8676
1.14
0.78
36.0
26.8
131.83
133.29
g/l
2.05
876
8548
13
198
0.65
0.77
1.8
1.4
—
—
—
0
0
10
59
1.70
0.76
1.3
1.2
—
—
—
0
0
103
896
1.17
0.75
2.6
2.1
0.20
0.21
g/l
0.82
96
831
41
326
1.27
0.73
2.1
1.8
—
—
—
0
0
110
965
1.16
0.72
3.9
3.5
—
—
—
0
0
28
211
1.34
0.72
1.5
1.4
—
—
—
0
0
7
39
1.80
0.72
1.0
1.3
—
—
—
0
0
7
40
1.76
0.71
2.0
1.2
—
—
—
0
0
7
40
1.76
0.71
2.0
1.2
—
—
—
0
0
15
101
1.49
0.70
1.1
1.3
1662.59
395.76
u/l
0.41
15
96
44
355
1.25
0.70
2.3
1.9
—
—
—
0
0
214
1965
1.11
0.70
1.8
1.8
445.66
21620369.63
pmol/l
1.44
168
1605
13
85
1.54
0.69
1.4
1.9
—
—
—
0
0
117
1037
1.14
0.68
2.6
2.6
8.35
7.86
umol/l
0.08
103
925
59
497
1.20
0.64
1.6
1.5
—
—
—
0
0
5
29
1.73
0.64
1.4
1.1
—
—
—
0
0
16
112
1.44
0.63
2.3
1.3
—
—
—
0
0
136
1506
0.89
0.63
1.4
1.3
45.90
33.28
iu/ml
0.58
42
476
14
96
1.46
0.61
1.5
1.4
0.21
0.18
nmol/l
0.52
14
70
16
113
1.42
0.61
1.2
1.3
24851.33
100148.21
e6/l
—
6
58
8
50
1.60
0.61
1.4
1.6
—
—
—
0
0
13
187
0.69
0.61
4.7
3.5
197.55
1676.02
u/ml
0.58
13
174
94
829
1.15
0.60
2.1
2.1
372.80
383.77
nmol/l
0.24
88
763
34
273
1.25
0.58
1.5
1.3
—
—
—
0
0
10
64
1.57
0.58
1.3
1.3
—
—
—
0
0
112
1002
1.13
0.58
2.4
2.3
146.48
138.79
ug/g
0.09
80
796
0
23
0.00
0.58
0.0
1.6
—
—
—
0
0
8
54
1.49
0.57
1.4
1.6
—
—
—
0
0
6
36
1.67
0.56
1.0
1.3
—
—
—
0
0
6
36
1.67
0.56
1.3
1.1
303.50
171.93
iu/ml
—
6
36
6
37
1.63
0.55
1.2
1.4
7.35
6.51
mmol/l
—
6
37
15
108
1.39
0.53
1.5
1.4
0.57
17.67
nmol/l
0.50
15
100
6
39
1.54
0.53
1.5
1.8
40.12
40.25
g/l
—
6
39
42
351
1.20
0.52
1.5
1.3
—
—
—
0
0
24
189
1.28
0.50
1.5
1.3
176.64
232.16
miu/ml
—
5
84
815
8006
1.09
0.49
6.5
6.0
2.51
2.64
mmol/l
4.12
758
7361
11
76
1.45
0.48
1.1
1.6
—
—
—
0
0
800
7856
1.08
0.48
5.7
5.2
4.45
4.56
mmol/l
2.33
736
7246
795
7806
1.08
0.47
5.5
5.1
1.45
1.46
mmol/l
0.26
733
7147
7
47
1.49
0.47
1.1
1.1
—
—
—
0
0
14
102
1.38
0.47
1.1
1.2
2.00
2.94
u/ml
—
8
34
7
48
1.46
0.47
1.6
1.5
—
—
—
0
0
793
7792
1.08
0.45
5.7
5.3
6.19
6.00
mmol/l
2.43
732
7069
12
86
1.40
0.44
1.7
1.3
1095.83
178260.57
e6/l
—
6
61
59
669
0.87
0.43
2.2
2.1
3.23
3.51
ratio
1.10
46
537
785
7715
1.07
0.43
23.3
17.3
75.08
77.12
ml/min/173m2
1.68
742
7173
5
32
1.57
0.42
1.2
1.1
—
—
—
0
0
30
249
1.21
0.42
1.5
1.4
—
—
—
0
0
8
58
1.38
0.41
2.0
1.3
—
—
—
0
0
8
58
1.38
0.41
2.0
1.3
—
—
—
0
0
14
105
1.34
0.41
1.1
1.2
1.67
7.47
u/ml
—
9
49
16
204
0.78
0.39
1.3
1.3
—
—
—
0
0
276
2636
1.06
0.38
5.4
5.7
5.54
2.74
ug/l
0.87
249
2354
24
197
1.22
0.38
1.5
1.3
—
—
—
0
0
24
197
1.22
0.38
1.5
1.3
—
—
—
0
0
42
366
1.15
0.36
1.2
1.3
—
—
—
0
0
5
78
0.64
0.35
1.2
1.5
—
25.58
—
0
12
6
42
1.43
0.35
1.0
1.1
—
1.24
—
0
26
10
73
1.37
0.34
1.1
1.0
—
—
—
0
0
11
82
1.35
0.34
2.1
1.6
—
—
—
0
0
24
200
1.20
0.34
1.1
1.2
—
—
—
0
0
547
5345
1.05
0.32
3.8
3.4
50.63
51.99
u/l
0.14
513
4992
7
98
0.71
0.31
1.0
1.1
—
—
—
0
0
10
75
1.34
0.30
1.0
1.1
—
—
—
0
0
27
231
1.17
0.30
1.2
1.2
—
—
—
0
0
257
2477
1.05
0.26
4.6
3.7
0.00
0.04
estimate
0.66
86
766
21
178
1.18
0.26
1.4
1.3
140.00
318.33
titre
—
5
12
15
123
1.22
0.25
1.5
1.7
—
—
—
0
0
94
1002
0.93
0.24
3.8
4.1
4.50
26.56
ug/l
1.80
74
826
28
246
1.14
0.24
2.8
2.2
126.48
126.21
g/l
0.01
21
195
36
324
1.12
0.22
2.0
1.6
0.48
0.32
mg/l
0.87
18
137
13
107
1.22
0.21
1.9
1.4
—
—
—
0
0
13
107
1.22
0.21
1.9
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
6.26
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
57
615
0.92
0.21
1.9
2.1
—
—
—
0
0
62
666
0.93
0.21
1.8
1.4
—
—
—
0
0
34
376
0.90
0.20
2.5
3.2
23.79
4058.54
u/ml
0.90
28
325
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
13
108
1.21
0.20
1.9
1.4
—
—
—
0
0
32
288
1.11
0.20
1.8
1.6
11.49
12.58
u/ml
—
7
61
6
49
1.23
0.20
1.2
1.6
100.00
78.65
umol/l
—
6
49
753
7460
1.03
0.18
4.8
4.4
1.30
1.28
mmol/l
0.36
688
6756
8
69
1.16
0.16
1.0
1.1
—
—
—
0
0
13
111
1.17
0.15
1.9
1.4
—
—
—
0
0
13
111
1.17
0.15
2.1
2.3
10.00
24.44
mg/l
—
5
42
30
275
1.09
0.14
1.6
1.3
27.00
26.41
iu/l
0.03
24
229
13
112
1.16
0.14
1.9
1.4
—
—
—
0
0
12
103
1.17
0.13
1.0
1.1
0.82
1.76
eliau/ml
—
5
41
47
500
0.94
0.13
1.1
1.2
124.00
140.78
u/ml
0.09
15
188
13
113
1.15
0.13
1.9
1.4
—
—
—
0
0
5
47
1.06
0.09
1.8
4.1
0.80
1.09
%
—
5
47
6
54
1.11
0.09
1.8
1.3
322.83
290.31
mu/l
—
6
42
54
562
0.96
0.08
1.9
1.9
—
—
—
0
0
5
65
0.77
0.08
1.2
1.2
—
—
—
0
0
13
117
1.11
0.08
1.0
1.1
0.17
1.35
u/ml
—
6
64
83
854
0.97
0.07
2.1
1.8
1.68
1.51
%
0.89
74
753
6
72
0.83
0.07
1.3
1.5
—
485.56
—
0
9
6
73
0.82
0.07
1.2
1.1
113.17
98.78
%
—
6
68
8
75
1.07
0.07
1.9
1.1
—
—
—
0
0
8
76
1.05
0.07
1.6
1.3
—
—
—
0
0
10
112
0.89
0.07
1.1
1.5
—
—
—
0
0
28
265
1.06
0.07
1.4
1.4
278.68
281.84
ug/g
0.03
14
152
27
256
1.06
0.06
1.8
1.6
—
—
—
0
0
63
612
1.03
0.06
2.2
2.4
15.07
13.09
nmol/l
1.00
53
548
32
306
1.05
0.05
2.1
2.1
—
—
—
0
0
24
253
0.95
0.05
2.2
2.2
—
—
—
0
0
213
2105
1.01
0.05
5.0
4.6
22.94
21.44
%
0.79
118
1044
23
219
1.05
0.04
2.1
1.9
45.04
40.53
nmol/l
0.38
23
208
38
372
1.02
0.01
1.1
1.1
—
—
—
0
0
155
1542
1.01
0.01
3.4
3.3
0.75
0.80
ug/l
0.34
117
1006
48
486
0.99
0.00
1.6
1.9
3.24
3.47
mmol/l
0.80
34
354
10
104
0.96
0.00
2.4
3.9
—
—
—
0
0
12
116
1.03
0.00
1.0
1.0
—
—
—
0
0
12
123
0.98
0.00
1.0
1.1
—
—
—
0
0
12
119
1.01
0.00
1.0
1.3
5.92
6.68
mmol/l
0.42
12
113
118
1177
1.00
0.00
1.3
1.5
—
—
—
0
0
6
67
0.89
0.00
1.3
1.4
—
57.14
—
0
7
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
5
51
0.98
-0.00
2.4
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
5.3
—
—
—
0
0
5
51
0.98
-0.00
2.4
1.7
—
—
—
0
0
9
98
0.92
-0.00
1.3
1.6
—
—
—
0
0
5
51
0.98
-0.00
2.4
1.7
—
—
—
0
0
8
83
0.96
-0.00
1.9
1.6
—
—
—
0
0
8
83
0.96
-0.00
1.9
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
-0.00
2.4
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
83
0.96
-0.00
1.9
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_GLOBE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLOBE | 1.188 [1.07, 1.32] | 0.002 |
| Birth year | 0.998 [0.99, 1.01] | 0.557 |
During the follow-up period (1.1.1998 — 31.12.2019), 1511 out of 3733 females with H7_GLOBE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLOBE | 1.391 [1.21, 1.59] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.047 |
During the follow-up period (1.1.1998 — 31.12.2019), 1101 out of 2981 males with H7_GLOBE died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLOBE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.145% | 0.279% |
| 5 | 0.882% | 1.903% |
| 10 | 1.939% | 4.507% |
| 15 | 3.542% | 8.496% |
| 20 | 6.097% | 13.929% |
Relationships between endpoints
↥Index endpoint: H7_GLOBE – Disorders of globe
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data