Hypotony of eye

H7_HYPOTONYEYE

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H44.4 Hospital discharge: ICD-9 — 3603 Cause of death: ICD-10 — H44.4 Cause of death: ICD-9 — 3603 2 out of 7 registries used, show all original rules.	60
4. Check minimum number of events None	60
5. Include endpoints None	60
6. Filter based on genotype QC (FinnGen only)	51

Control definitions (FinnGen only)

Control exclude: H7_VITREOUS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H44
Name in latin: Hypotonia oculi

NAME	H7_HYPOTONYEYE
CONTROL_EXCLUDE	H7_VITREOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H444
HD_ICD_9	3603
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H444
COD_ICD_9	3603
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Hypotony of eye based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	339	172	164
Only index persons	309	157	152
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	64.21	68.73	59.51
Only index persons	62.95	67.65	58.08

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	51	27	24
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	66.34	64.79	68.09

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
53: Matched controls
530

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H44.4

ICD-10 Finland

Hypotony of eye

+∞

75.9

S01ED51

ATC

timolol, combinations; ophthalmic

41.0

43.5

114

Kela drug reimbursment

Glaucoma

30.9

37.3

S01EA05

ATC

brimonidine; ophthalmic

143.2

28.2

Z96.1

ICD-10 Finland

Presence of intraocular lens

14.5

22.6

WX140

NOMESCO Finland

Parabulbar anesthesy

37.8

21.8

S01ED01

ATC

timolol; ophthalmic

50.6

21.2

S01EC04

ATC

brinzolamide; ophthalmic

38.3

19.1

S01EE01

ATC

latanoprost; ophthalmic

20.3

16.1

H40.13

ICD-10 Finland

Chronic glaucoma with open ventricular angle

30.5

15.9

S01EE04

ATC

travoprost; ophthalmic

52.9

15.7

H20.1

ICD-10 Finland

Chronic iridocyclitis

+∞

15.3

S01EC01

ATC

acetazolamide; systemic

48.6

14.6

S01EE03

ATC

bimatoprost; ophthalmic

48.6

14.6

CHD99

NOMESCO Finland

Other filtering operation

+∞

14.2

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

9.1

14.1

CHD50

NOMESCO Finland

Shunt operation on anterior chamber

+∞

13.0

XCW99

NOMESCO Finland

Other investigative procedure of eye

13.7

13.0

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic

8.7

13.0

128

XCK00

NOMESCO Finland

Perimetry

15.7

12.5

CHC05

NOMESCO Finland

Iridotomy

151.6

11.9

H40.5

ICD-10 Finland

Glaucoma secondary to other eye disorders

151.6

11.9

H40.10

ICD-10 Finland

Capsular glaucoma with pseudoexfoliation on the anterior lens capsule

33.9

11.9

Z01.0

ICD-10 Finland

Examination of eyes and vision

6.8

11.1

CHD65

NOMESCO Finland

Nonpenetrating glaucoma surgery

135.8

10.8

WX100

NOMESCO Finland

Conjunctival surface anesthesia

6.9

10.7

WX002

NOMESCO Finland

Sedation and analgesia

6.4

10.1

CFW99

NOMESCO Finland

Other operation on conjunctiva

67.9

10.1

H40.0

ICD-10 Finland

Glaucoma suspect

10.4

9.8

CHD15

NOMESCO Finland

Trabeculectomy and iridectomy

120.7

9.8

H20.0

ICD-10 Finland

Acute and subacute iridocyclitis

20.5

9.7

XCH05

NOMESCO Finland

Eye pressure longterm registration

+∞

9.7

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

6.5

9.6

149

S01EE05

ATC

tafluprost; ophthalmic

15.5

9.3

S01EC54

ATC

brinzolamide, combinations; ophthalmic

33.9

8.9

ZXC20

NOMESCO Finland

Use of chemical agents

33.9

8.9

CHD35

NOMESCO Finland

Laser goniopuncture

106.3

8.7

H40.4

ICD-10 Finland

Glaucoma secondary to eye inflammation

+∞

8.6

XCK10

NOMESCO Finland

Photography of fundus of eye

8.6

8.4

S01BC03

ATC

diclofenac; ophthalmic

30.1

7.9

ZXA00

NOMESCO Finland

Right side

5.0

7.8

TCA20

NOMESCO Finland

Peribulbar therapeutic injection into orbit

+∞

7.5

S01BA04

ATC

prednisolone; ophthalmic

35.4

7.4

S01EA03

ATC

apraclonidine; ophthalmic

46.1

7.0

S01BA07

ATC

fluorometholone; ophthalmic

46.1

7.0

S01EC03

ATC

dorzolamide; ophthalmic

46.1

7.0

CHC03

NOMESCO Finland

Laser iridoplasty

79.0

6.6

WX006

NOMESCO Finland

Intravenous sedation or analgesia without general anesthesia

8.2

6.4

T85.2

ICD-10 Finland

Mechanical complication of intraocular lens

+∞

6.4

CHD05

NOMESCO Finland

Selective lasertrabeculoplasty

11.2

6.1

ZXA05

NOMESCO Finland

Left side

4.2

6.1

CS1H4

NOMESCO Finland

Retinal nerve fibre layer imaging

13.3

6.1

H26.4

ICD-10 Finland

After-cataract

6.5

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3017732) Neutrophils [#/volume] in Blood

3.21

2.8

3.9

5.05

5.01

e9/l

0.02

(40758558) Short blood count panel - Blood

142

2.44

2.53

9.5

6.3

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

472

+∞

2.21

31.8

23.0

78.06

79.75

umol/l

0.24

466

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

5.39

2.12

7.0

1.6

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

2.55

1.97

10.5

3.6

269.15

233.83

u/l

0.27

(3021879) Hepatitis B virus core Ab [Presence] in Serum

3.06

1.88

1.5

—

(3007461) Platelets [#/volume] in Blood

481

+∞

1.80

35.6

25.5

234.49

247.80

e9/l

1.03

475

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.43

1.70

2.9

1.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.56

1.67

1.7

1.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.38

1.64

1.8

1.4

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.13

1.51

3.0

2.0

2.11

2.29

g/l

0.48

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

100

2.03

1.46

2.1

2.3

2.42

2.46

mmol/l

0.50

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.26

1.39

2.7

1.6

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

417

2.60

1.33

5.5

6.1

2.14

1.95

mu/l

0.47

374

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

175

1.81

1.26

4.6

3.4

—

(3035350) Ketones [Presence] in Urine by Test strip

253

1.81

1.21

7.1

4.5

0.00

estimate

-0.00

(3021601) Nitrite [Presence] in Urine by Test strip

254

1.79

1.19

6.5

4.5

0.00

estimate

-0.00

(3023368) Bacteria identified in Blood by Culture

143

1.78

1.14

6.0

4.0

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

1.91

1.11

4.5

3.1

0.33

3.51

e6/l

—

(3009261) Glucose [Presence] in Urine by Test strip

259

1.73

1.06

6.8

4.6

0.00

estimate

—

(42870588) Differential panel, method unspecified - Blood

156

1.70

1.02

11.0

5.2

—

(3022948) Iron [Moles/volume] in Serum or Plasma

1.83

1.00

3.1

2.1

8.47

14.97

umol/l

2.70

(3002582) Erythrocytes [#/volume] in Urine

175

1.68

1.00

4.2

3.3

48.41

422.52

e6/l

0.47

127

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

214

1.65

0.97

2.0

92.88

97.72

pmol/l

0.27

(3018095) Leukocytes [#/volume] in Urine

195

1.65

0.97

6.2

4.1

313.62

45.19

e6/l

0.52

136

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

1.76

0.94

4.9

3.0

0.76

0.99

e6/l

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.76

0.94

10.0

6.7

—

(3012516) Albumin [Mass/volume] in Urine

160

1.64

0.91

3.2

3.6

13.59

54.31

mg/l

1.20

104

(3000494) Fungus identified in Specimen by Culture

1.93

0.91

1.2

1.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

246

1.63

0.90

3.2

2.9

—

(3020682) Albumin/Creatinine [Ratio] in Urine

170

1.62

0.89

3.6

4.0

1.77

8.65

mg/mmol

1.47

103

(3015736) pH of Urine

200

1.59

0.84

5.6

4.1

6.61

6.22

0.97

114

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.78

0.83

1.3

1.5

—

(3042936) Bacteria identified in Isolate by Culture

1.86

0.82

1.5

1.8

—

(3027945) Reticulocytes/Erythrocytes in Blood

1.88

0.82

6.9

1.8

1.88

1.84

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.88

0.82

4.6

1.7

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

0.00

0.81

0.0

3.7

—

48.70

—

(3019309) Folate [Moles/volume] in Red Blood Cells

1.73

0.81

2.0

1.7

1435.38

1305.62

nmol/l

0.19

(3030467) Casts [#/volume] in Urine by Automated count

155

1.59

0.80

4.5

3.2

0.12

0.50

e6/l

1.88

110

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

1.68

0.75

4.5

3.2

0.77

0.74

ug/l

0.06

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.66

0.74

4.6

3.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

113

1.60

0.72

5.9

4.6

26.51

21.99

0.45

(3018010) Neutrophils/Leukocytes in Blood

206

1.51

0.71

13.0

6.3

57.25

58.93

0.32

196

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.63

0.68

2.8

1.7

—

(3003338) MCHC [Entitic Mass/volume] in Red Blood Cells

361

1.60

0.66

30.4

22.4

332.07

332.39

g/l

0.09

361

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.86

0.61

3.2

1.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.80

0.60

1.3

1.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.57

0.58

1.8

1.4

—

(3003694) ABO and Rh group [Type] in Blood

120

1.48

0.54

1.5

1.3

—

(3000492) Spirometry study

1.56

0.53

2.2

1.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

215

1.41

0.53

2.7

2.6

—

estimate

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

447

1.78

0.50

25.7

16.7

24.61

22.51

mg/l

0.19

368

(3026008) Bacteria identified in Urine by Culture

150

1.42

0.50

2.5

3.3

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.42

0.0

1.2

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

155

1.24

0.24

7.0

5.8

2.70

2.23

ug/l

0.28

136

(40768804) Tissue Pathology biopsy report

175

1.23

0.23

1.7

2.1

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.21

0.0

1.2

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.1

—

(3004809) Band form neutrophils/Leukocytes in Blood

0.00

0.21

0.0

3.2

—

2.75

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

0.00

0.21

0.0

1.1

—

0.89

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

0.00

0.21

0.0

2.0

—

93.08

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.21

0.0

1.3

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.21

0.0

2.7

—

107.75

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

2.7

—

1.20

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

2.7

—

3.97

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.21

0.0

1.3

—

112.80

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.21

0.0

4.6

—

21.07

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

848.77

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.20

0.0

1.9

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.6

—

(3029937) Albumin [Presence] in Urine by Test strip

149

1.21

0.19

6.4

4.3

0.00

estimate

-0.00

(3013826) Glucose [Moles/volume] in Serum or Plasma

290

1.17

0.15

4.0

5.2

6.24

6.65

mmol/l

1.11

277

(3041096) Erythrocytes [Presence] in Urine by Automated

143

1.17

0.13

5.2

3.8

0.00

estimate

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

116

0.83

0.13

1.8

2.6

—

(40761536) Microorganisms panel - Urine sediment

1.12

0.10

6.8

3.8

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.82

0.09

30.8

9.2

—

(3016502) Oxygen saturation in Arterial blood

0.82

0.09

1.8

7.5

96.76

95.52

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

0.77

0.09

1.8

7.2

4.70

5.06

kpa

—

(3027801) Oxygen [Partial pressure] in Arterial blood

0.77

0.09

1.8

7.2

10.86

11.94

kpa

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.07

0.08

2.4

1.6

—

(1761868) Lipid panel - Serum or Plasma

177

1.11

0.08

2.9

3.2

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.08

0.08

2.8

6.4

105.00

103.36

mmol/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

199

1.09

0.05

6.2

4.2

0.10

0.00

estimate

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

170

0.92

0.05

3.7

3.0

44.19

31.52

u/l

0.54

155

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

211

1.07

0.03

4.8

4.1

17.19

36.28

ng/l

1.24

160

(3021960) Folate [Moles/volume] in Serum or Plasma

152

1.08

0.03

1.9

1.6

21.73

19.02

nmol/l

0.34

121

(3013512) EKG study

194

1.05

0.00

5.1

3.7

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

177

1.03

0.00

2.7

2.9

2.35

mmol/l

0.02

158

(3044640) Blood type and Crossmatch panel - Blood

148

1.02

0.00

2.1

2.4

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.1

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

2.2

—

221.33

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.2

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.0

1.6

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

2.9

—

98.63

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3011648) Oxygen content in Venous blood

0.00

0.0

1.1

—

10.21

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.94

0.00

1.5

1.6

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

-0.00

0.0

1.3

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

-0.00

0.0

1.2

—

(3002256) Pathology report gross observation

0.83

-0.00

1.0

1.3

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.3

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3026285) Alpha 1 antitrypsin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

1.43

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

-0.00

0.0

9.7

—

(4195642) Thrombophilia screening test

0.00

-0.00

0.0

1.3

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

-0.00

0.0

2.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.2

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

-0.00

0.0

1.7

—

16.50

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

-0.00

0.0

1.0

—

(40768797) Stomach Pathology biopsy report

0.93

-0.00

1.2

1.3

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.3

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(44806420) Estimation of glomerular filtration rate

0.00

-0.00

0.0

3.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

-0.00

0.0

1.2

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.2

—

(3024980) IgG subclass 4 [Mass/volume] in Serum

0.00

-0.00

0.0

1.2

—

0.79

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.3

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.0

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

1.00

-0.00

1.6

7.3

0.96

1.06

mmol/l

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

1.0

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

-0.00

0.0

1.2

—

6.30

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

-0.00

0.0

1.0

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.5

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.6

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

1.5

—

(4268621) Lupus anticoagulant assay

0.00

-0.00

0.0

1.9

—

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.3

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

-0.00

0.0

1.6

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

-0.00

0.0

2.3

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

0.98

-0.00

2.4

1.3

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_HYPOTONYEYE and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_HYPOTONYEYE.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H7_HYPOTONYEYE – Hypotony of eye

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Hypotony of eye

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints