No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
232 |
4. Check minimum number of eventsNone |
232 |
5. Include endpointsNone |
232 |
6. Filter based on genotype QC (FinnGen only) |
205 |
Control definitions (FinnGen only)
- Control exclude
- H7_VITREOUS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H44
- Name in latin
- Degeneratio bulbi oculi
Similar endpoints
↥List of similar endpoints to
Degenerative conditions of globe
based on the number of shared cases.
Similar with more cases:
- Disorders of globe
- Disorders of vitreous body and globe
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3241 | 1579 | 1622 |
| Only index persons | 2177 | 1098 | 1079 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.05 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 71.66 | 76.48 | 66.95 |
| Only index persons | 69.72 | 76.15 | 63.17 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 205 | 76 | 129 |
| Unadjusted period prevalence (%) | 0.05 | 0.03 | 0.06 |
| Median age at first event (years) | 66.27 | 65.97 | 66.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 206
- Matched controls
- 2060
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H44.5
ICD-10 Finland
Degenerated conditions of globe
+∞
227.5
174
*
S01ED51
ATC
timolol, combinations; ophthalmic
19.4
100.8
102
99
114
Kela drug reimbursment
Glaucoma
15.9
91.5
112
144
S01ED01
ATC
timolol; ophthalmic
22.1
89.2
76
53
S01EA05
ATC
brimonidine; ophthalmic
37.2
81.0
53
19
S01EX03, ,
ATC
28.8
78.9
57
27
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
53.6
78.2
46
11
S01EC01
ATC
acetazolamide; systemic
25.2
78.1
60
33
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
14.9
45.2
44
37
S01EE01
ATC
latanoprost; ophthalmic
9.8
44.7
62
87
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
9.9
35.6
46
58
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
12.5
31.2
33
31
H33.0
ICD-10 Finland
Retinal detachment with retinal break
13.3
29.8
30
26
S01BA01
ATC
dexamethasone; ophthalmic
10.9
26.9
31
33
Z96.1
ICD-10 Finland
Presence of intraocular lens
4.8
25.4
80
240
H43.1
ICD-10 Finland
Vitreous haemorrhage
147.9
25.2
26
*
H54.4
ICD-10 Finland
Blindness, monocular
147.9
25.2
26
*
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
147.9
25.2
26
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.9
23.6
67
184
S01EC03
ATC
dorzolamide; ophthalmic
30.1
23.5
31
12
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.3
23.1
129
581
XCK00
NOMESCO Finland
Perimetry
6.9
23.0
40
70
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
8.1
21.9
32
46
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
4.0
21.6
125
570
H16.0
ICD-10 Finland
Corneal ulcer
7.5
20.7
32
49
Z97.0
ICD-10 Finland
Presence of artificial eye
110.2
18.9
20
*
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
49.0
18.6
22
5
WX140
NOMESCO Finland
Parabulbar anesthesy
7.1
18.6
30
48
S01EC04
ATC
brinzolamide; ophthalmic
7.0
18.2
30
49
CHF15
NOMESCO Finland
Cryotherapy of ciliary body
+∞
16.9
16
*
37861
ICD-8 Finland
Other diseases of eye, Phthisis et degeneratio bulbi
+∞
16.9
16
*
S01EA03
ATC
apraclonidine; ophthalmic
30.5
16.9
22
8
S01EB01
ATC
pilocarpine; ophthalmic
23.2
15.0
21
10
H04.10
ICD-10 Finland
Dry eye syndrome
4.6
14.1
37
93
CDC00
NOMESCO Finland
Enucleation of eye
80.6
13.8
15
*
TCA15
NOMESCO Finland
Retrobulbar therapeutic injection into orbit
+∞
13.7
13
*
H54.0
ICD-10 Finland
Blindness, binocular
149.4
13.6
14
*
S01FA01
ATC
atropine; ophthalmic
28.0
13.6
18
7
S01EA02
ATC
dipivefrine; ophthalmic
23.1
13.6
19
9
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.2
13.0
40
113
S01BA07
ATC
fluorometholone; ophthalmic
16.9
12.9
20
13
H43.8
ICD-10 Finland
Other disorders of vitreous body
21.8
12.7
18
9
25002
ICD-8 Finland
Diabetes mellitus, Retinopathia diabetica
+∞
12.6
12
*
37520
ICD-8 Finland
Glaucoma, Secondary
138.1
12.6
13
*
H40.0
ICD-10 Finland
Glaucoma suspect
4.7
12.3
31
75
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
12.2
11.8
21
19
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
11.1
11.8
22
22
H3603, E103,
ICD-10 Finland
69.0
11.7
13
*
37514
ICD-8 Finland
Glaucoma, Chronicum absolutum s. fero absolutum dolorosum
+∞
11.6
11
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
37.3
11.4
14
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
11.5
11.0
20
19
A10AB01
ATC
insulin (human); parenteral
5.4
11.0
23
47
A10AA02, ,
ATC
4.9
10.8
25
56
S01BC03
ATC
diclofenac; ophthalmic
10.9
10.8
20
20
XCK10
NOMESCO Finland
Photography of fundus of eye
3.7
10.6
38
119
S01AX11
ATC
[U] ofloxacin
5.9
10.6
20
37
3604A
ICD-9 Finland
Disorders of the globe, Degenerated conditions of globe
+∞
10.5
10
*
H26.2
ICD-10 Finland
Complicated cataract
34.5
10.5
13
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
42.3
10.1
12
*
Z3229
NOMESCO Finland
Other healthcare associate professional
3.7
10.0
35
108
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
27.6
9.9
13
5
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
31.7
9.5
12
*
H54.1
ICD-10 Finland
Severe visual impairment, binocular
+∞
9.4
9
*
S01BA04
ATC
prednisolone; ophthalmic
9.0
9.3
19
23
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.7
9.2
32
98
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
25.3
9.0
12
5
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
25.3
9.0
12
5
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
5.1
8.8
19
40
H20.1
ICD-10 Finland
Chronic iridocyclitis
52.3
8.8
10
*
CKD15
NOMESCO Finland
Injection of vitreous substitute
52.3
8.8
10
*
A10AA01, ,
ATC
7.3
8.6
20
30
XCH00
NOMESCO Finland
Eye pressure measurement
4.8
8.6
20
45
H18.1
ICD-10 Finland
Bullous keratopathy
93.7
8.5
9
*
CDC40
NOMESCO Finland
Evisceration of eye with insertion of prosthesis
+∞
8.4
8
*
S01AA01
ATC
chloramphenicol; ophthalmic
5.1
8.3
18
38
H3603, E113,
ICD-10 Finland
23.1
8.1
11
5
S01FA02
ATC
scopolamine; ophthalmic
23.1
8.1
11
5
S01EE05
ATC
tafluprost; ophthalmic
6.6
8.1
20
33
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
8.3
8.1
17
22
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
9.0
8.0
16
19
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
4.2
7.9
22
57
H01.0
ICD-10 Finland
Blepharitis
4.8
7.8
18
40
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
4.8
7.8
18
40
H21.0
ICD-10 Finland
Hyphaema
46.8
7.8
9
*
S01EE03
ATC
bimatoprost; ophthalmic
9.4
7.7
15
17
127
Kela drug reimbursment
Transplant complication
26.1
7.6
10
*
37510
ICD-8 Finland
Glaucoma, Chronicum simplex
83.0
7.5
8
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
4.1
7.5
21
55
H04AA01
ATC
glucagon; nasal, parenteral
8.9
7.5
15
18
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
6.2
7.4
19
33
TCG10
NOMESCO Finland
Removal of sutures from cornea
+∞
7.3
7
*
3711
FHL
Cyclodiateria or cryocoagulation
+∞
7.3
7
*
A10AB05
ATC
insulin aspart; parenteral
3.2
7.2
30
103
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
9.3
7.2
14
16
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.1
7.0
20
53
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
14.4
7.0
11
8
S01ED02
ATC
betaxolol; ophthalmic
8.7
6.9
14
17
C08CA02
ATC
felodipine; oral
3.0
6.9
34
129
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
11.5
6.9
12
11
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
17.4
6.8
10
6
H40.8
ICD-10 Finland
Other glaucoma
41.5
6.8
8
*
3643
FHL
Vitrectomy through pars Plana
41.5
6.8
8
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.2
6.8
100
627
Z94.0
ICD-10 Finland
Kidney transplant status
23.4
6.7
9
*
CKD40
NOMESCO Finland
Endophotocoagulation of retina
12.8
6.7
11
9
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
12.8
6.7
11
9
S01BC05
ATC
ketorolac; ophthalmic
3.7
6.6
22
65
3708
FHL
Trabeculectomy or equivalent
72.0
6.5
7
*
CHD99
NOMESCO Finland
Other filtering operation
72.0
6.5
7
*
CKC65
NOMESCO Finland
Removal of buckling implant from sclera
+∞
6.3
6
*
3745
FHL
Hard membrane girding, cerclage with coagulation
+∞
6.3
6
*
F94
ICPC
Blindness
+∞
6.3
6
*
H44.0
ICD-10 Finland
Purulent endophthalmitis
+∞
6.3
6
*
3747
FHL
Combined ablation and vitreous surgery with coagulation
+∞
6.3
6
*
H33.4
ICD-10 Finland
Traction detachment of retina
+∞
6.3
6
*
H05.0
ICD-10 Finland
Acute inflammation of orbit
+∞
6.3
6
*
L04AD01
ATC
ciclosporin; systemic
27.6
6.3
8
*
CKC20
NOMESCO Finland
Cryopexy of undetached retina
27.6
6.3
8
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
5.5
6.2
17
33
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.8
6.2
33
131
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
7.1
6.1
14
21
H57.1
ICD-10 Finland
Ocular pain
6.4
6.1
15
25
S01EE04
ATC
travoprost; ophthalmic
7.6
6.0
13
18
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
86
599
1.75
3.66
3.4
2.5
75.74
77.35
nmol/l
0.20
74
523
34
180
2.06
3.35
9.7
9.0
—
—
—
0
0
6
7
8.78
3.28
1.5
2.0
—
—
—
0
0
29
146
2.15
3.25
3.6
2.8
3.96
6.45
ug/l
0.83
20
123
55
347
1.80
3.23
4.2
4.5
1.02
1.02
kg/l
0.38
34
231
25
120
2.23
3.14
1.8
1.5
—
—
—
0
0
36
202
1.95
3.02
3.5
6.6
2.29
1.07
mmol/l
1.13
27
166
92
684
1.62
2.90
7.1
5.0
34.47
34.94
g/l
0.32
82
639
23
114
2.15
2.68
4.5
6.3
24.70
24.22
mmol/l
0.23
23
109
68
484
1.60
2.50
2.4
2.0
200.56
259.69
u/l
0.37
63
452
98
768
1.53
2.32
13.6
7.3
1.20
1.21
mmol/l
0.18
88
650
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
12
47
2.65
2.31
3.3
2.4
0.32
0.33
iu/ml
—
6
25
5
10
5.09
2.08
1.0
1.2
—
—
—
0
0
6
16
3.83
1.95
1.8
1.6
—
—
—
0
0
25
145
1.82
1.92
2.8
2.8
0.36
0.34
e6/l
0.03
25
139
16
79
2.11
1.91
4.1
5.0
1.59
1.52
%
0.15
16
73
6
17
3.60
1.85
1.8
1.6
—
—
—
0
0
6
17
3.60
1.85
1.8
1.6
—
—
—
0
0
6
17
3.60
1.85
1.8
1.6
—
—
—
0
0
66
498
1.48
1.79
6.1
4.1
12.75
11.31
mg/mmol
0.10
50
313
6
18
3.40
1.76
1.8
1.6
—
—
—
0
0
6
18
3.40
1.76
1.8
1.6
—
—
—
0
0
85
688
1.40
1.55
11.9
6.2
1.20
1.21
mmol/l
0.11
77
629
18
101
1.86
1.54
7.1
6.0
25.61
24.72
mmol/l
0.51
18
101
5
15
3.39
1.53
3.2
2.7
—
—
—
0
0
5
15
3.39
1.53
2.2
1.3
—
—
—
0
0
5
15
3.39
1.53
1.0
1.6
9.60
16.87
u/l
—
5
15
9
37
2.50
1.50
2.2
1.2
—
—
—
0
0
22
134
1.72
1.46
8.6
3.0
4.85
4.18
kpa
0.93
22
127
25
158
1.66
1.46
10.4
4.1
5.72
5.73
kpa
0.02
25
151
83
678
1.38
1.41
4.8
4.4
192.50
51.88
ng/l
0.52
67
522
26
380
0.64
1.32
3.3
3.3
0.76
0.83
ug/l
0.25
20
251
39
282
1.47
1.29
2.4
1.9
—
—
—
0
0
5
18
2.82
1.29
1.6
1.7
—
—
—
0
0
9
44
2.09
1.28
1.3
1.4
—
—
—
0
0
48
362
1.42
1.28
3.4
2.3
—
—
—
0
0
42
315
1.42
1.16
2.1
1.8
1146.97
1226.97
nmol/l
0.27
34
240
5
20
2.54
1.16
1.6
1.3
—
—
—
0
0
7
30
2.38
1.13
1.0
1.4
—
—
—
0
0
38
281
1.43
1.13
1.3
1.3
7.77
1.11
u/ml
—
6
87
12
66
1.87
1.11
2.6
2.0
—
—
—
0
0
8
41
1.99
1.10
1.6
1.6
—
—
—
0
0
90
768
1.31
1.08
5.1
4.3
0.00
9.50
estimate
0.50
14
171
89
759
1.30
1.07
5.2
4.2
0.00
0.00
estimate
-0.00
14
167
16
98
1.69
1.07
4.1
3.0
75.33
65.38
ml/min/173m2
—
6
42
7
33
2.16
1.06
1.1
1.5
—
—
—
0
0
55
438
1.35
1.06
3.1
2.2
3.03
3.21
mg/l
0.25
46
374
79
664
1.31
1.05
2.5
2.1
92.51
96.14
pmol/l
0.27
45
339
67
551
1.32
1.04
5.2
3.3
—
—
—
0
0
5
22
2.30
1.04
1.2
1.3
—
—
—
0
0
15
92
1.68
1.00
1.5
1.4
—
—
—
0
0
0
30
0.00
0.98
0.0
1.1
—
0.74
—
0
24
41
520
0.74
0.97
5.5
4.8
24.03
22.83
%
0.21
27
264
28
202
1.45
0.96
2.2
1.8
—
—
—
0
0
90
779
1.28
0.94
5.2
4.3
0.08
1.87
estimate
0.48
12
163
11
63
1.79
0.92
2.5
1.8
—
—
—
0
0
79
680
1.26
0.85
3.3
2.8
—
—
estimate
—
0
0
125
1359
0.80
0.83
6.9
5.9
2.42
2.55
mmol/l
0.74
114
1231
116
1271
0.80
0.82
5.4
4.3
1.39
1.29
mmol/l
1.01
103
1137
71
606
1.26
0.82
4.7
4.3
0.20
0.08
estimate
—
10
147
26
193
1.40
0.78
2.3
1.9
—
—
—
0
0
30
229
1.36
0.77
8.3
6.1
104.03
103.80
mmol/l
0.10
30
229
7
38
1.87
0.74
1.1
1.5
—
0.06
—
0
12
120
1095
1.23
0.73
33.4
23.3
331.94
331.88
g/l
0.02
120
1085
14
93
1.54
0.71
1.8
1.9
—
—
—
0
0
67
578
1.24
0.69
3.4
3.4
2079.56
1842.42
ng/l
0.17
58
480
54
456
1.25
0.67
4.8
4.2
0.00
0.01
estimate
0.50
11
144
5
28
1.80
0.66
1.4
1.5
—
—
—
0
0
58
672
0.81
0.66
5.3
5.7
6.28
2.72
ug/l
0.38
52
585
61
525
1.23
0.64
3.1
3.3
2.32
2.35
mmol/l
1.08
53
475
11
72
1.56
0.60
4.4
4.5
1.02
1.02
ratio
0.23
11
67
6
37
1.64
0.56
1.5
1.2
—
—
—
0
0
9
60
1.52
0.55
1.8
2.9
—
—
—
0
0
6
38
1.60
0.55
1.5
1.2
—
—
—
0
0
6
38
1.60
0.55
1.3
1.6
—
—
—
0
0
6
40
1.51
0.52
1.3
1.3
—
—
—
0
0
9
128
0.69
0.45
1.6
1.4
—
—
—
0
0
119
1116
1.16
0.44
9.7
7.9
95.38
81.05
u/l
0.78
114
1056
87
798
1.16
0.44
4.4
6.2
11.06
12.60
umol/l
0.83
81
753
59
525
1.17
0.44
2.2
2.0
1.47
1.32
mmol/l
0.94
49
427
5
31
1.63
0.43
1.4
1.6
—
—
—
0
0
126
1329
0.87
0.42
6.2
5.2
4.31
4.43
mmol/l
0.59
112
1212
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
5
35
1.44
0.39
1.6
2.3
—
—
—
0
0
39
445
0.85
0.37
4.0
3.7
0.00
0.20
estimate
0.57
12
138
125
1313
0.88
0.37
24.0
17.9
70.56
75.26
ml/min/173m2
1.24
119
1227
6
43
1.41
0.35
1.3
1.5
—
—
—
0
0
6
43
1.41
0.35
1.5
2.3
—
—
—
0
0
126
1319
0.88
0.34
6.2
5.1
1.35
1.41
mmol/l
0.96
111
1189
109
1030
1.12
0.33
4.8
4.0
15.36
15.08
pmol/l
0.45
92
906
50
451
1.14
0.31
1.8
1.7
19.69
20.27
nmol/l
0.09
40
366
50
453
1.14
0.29
4.8
3.1
37.04
31.55
u/l
0.40
50
430
125
1303
0.90
0.29
10.0
6.8
43.82
40.47
mmol/mol
2.41
113
1207
127
1320
0.90
0.27
5.7
5.3
6.54
6.10
mmol/l
1.98
111
1183
9
72
1.26
0.26
3.6
3.3
11.56
3063.19
u/ml
—
9
64
20
170
1.20
0.25
1.2
1.5
—
—
—
0
0
43
391
1.13
0.24
3.0
3.1
395.89
364.95
umol/l
1.27
38
333
69
645
1.10
0.24
4.2
2.9
182.22
142.75
ug/l
0.64
63
588
36
324
1.13
0.24
1.8
1.6
1.68
1.53
mg/l
0.16
29
250
47
432
1.11
0.22
4.4
3.0
0.23
0.45
e6/l
0.78
41
324
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
5
43
1.17
0.21
6.8
1.7
—
—
—
0
0
5
43
1.17
0.21
1.4
1.5
—
—
—
0
0
140
1439
0.92
0.20
15.8
12.0
29.75
25.09
u/l
0.86
135
1393
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
28
251
1.13
0.20
3.9
3.0
0.26
1.26
e6/l
2.88
21
129
7
58
1.21
0.18
1.4
1.3
—
—
—
0
0
7
59
1.19
0.18
1.0
1.0
—
—
—
0
0
39
360
1.10
0.17
1.7
1.9
379.38
18750424.90
pmol/l
0.50
29
304
28
254
1.12
0.17
3.2
3.2
0.82
0.83
mmol/l
0.10
28
235
26
236
1.12
0.15
4.0
3.1
0.93
1.65
e6/l
0.55
17
114
12
102
1.19
0.15
1.5
1.3
—
—
—
0
0
129
1257
1.07
0.15
6.0
5.0
2.19
2.06
mu/l
0.46
115
1122
8
100
0.79
0.14
2.6
2.1
—
—
—
0
0
17
188
0.90
0.11
1.1
1.3
1.20
11.77
u/ml
—
8
70
141
1386
1.05
0.10
27.9
17.8
29.81
26.82
mg/l
0.42
125
1178
5
44
1.14
0.10
1.2
2.2
219.00
203.52
%
—
5
44
83
806
1.05
0.10
9.7
9.9
4.84
4.17
e9/l
2.01
73
702
6
54
1.11
0.09
1.3
1.3
—
—
—
0
0
8
75
1.07
0.07
2.9
3.1
4.55
4.31
pmol/l
—
8
66
76
742
1.04
0.06
3.4
2.8
—
—
—
0
0
18
192
0.93
0.05
6.7
4.9
33.33
32.42
%
—
9
123
106
1048
1.02
0.03
5.9
4.3
19.04
13.55
mm/h
1.46
96
965
143
1436
0.99
0.00
34.4
21.3
139.64
139.54
mmol/l
0.17
138
1401
18
181
0.99
0.00
2.5
3.4
—
—
—
0
0
147
1467
1.01
0.00
34.8
23.6
95.65
85.41
umol/l
1.11
142
1441
144
1435
1.01
0.00
34.8
21.6
4.01
4.01
mmol/l
0.00
138
1395
5
51
0.98
0.00
2.8
3.9
0.00
0.00
g/l
—
5
46
0
8
0.00
0.00
0.0
1.5
—
52.96
—
0
8
5
51
0.98
0.00
1.4
5.4
2.09
5.99
ratio
—
5
27
5
50
1.00
0.00
2.8
4.0
0.00
0.00
g/l
—
5
42
0
5
0.00
-0.00
0.0
1.6
—
87.40
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
13.63
—
0
7
8
87
0.92
-0.00
2.4
2.0
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
6
0.00
-0.00
0.0
2.8
—
145.67
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.0
—
209.00
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
12.60
—
0
6
0
6
0.00
-0.00
0.0
1.5
—
115.33
—
0
6
5
54
0.92
-0.00
1.4
5.7
49.36
189.88
mg/l
—
5
46
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
9.17
—
0
6
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
54
0.92
-0.00
1.4
5.7
34.32
30.66
mg/l
—
5
47
Mortality – FinRegistry
↥Association
Association between endpoint H7_GLOBEDEGENERATED and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLOBEDEGENERATED | 1.333 [1.16, 1.54] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.296 |
During the follow-up period (1.1.1998 — 31.12.2019), 733 out of 1161 females with H7_GLOBEDEGENERATED died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLOBEDEGENERATED | 1.488 [1.24, 1.78] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 564 out of 1066 males with H7_GLOBEDEGENERATED died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLOBEDEGENERATED.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.104% | 0.31% |
| 5 | 0.751% | 1.805% |
| 10 | 1.846% | 4.363% |
| 15 | 3.805% | 8.382% |
| 20 | 6.9% | 14.242% |
Relationships between endpoints
↥Index endpoint: H7_GLOBEDEGENERATED – Degenerative conditions of globe
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data