Respiratory and cardiovascular disorders specific to the perinatal period

P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 P20-P29
  • Cause of death: ICD-10 P20-P29

2 out of 7 registries used, show all original rules.

990

4. Check minimum number of events

None

990

5. Include endpoints

990

6. Filter based on genotype QC (FinnGen only)

869

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P
Name in latin
Perturbationes respiratoriae et cardiovasculares temporis perinatalis specificae

Similar endpoints

List of similar endpoints to Respiratory and cardiovascular disorders specific to the perinatal period based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 72975 31693 41278
Only index persons 31986 13548 18438
Unadjusted period prevalence (%)
Whole population 1.05 0.91 1.15
Only index persons 0.62 0.50 0.70
Median age at first event (years)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00

-FinnGen-

Key figures

All Female Male
Number of individuals 869 468 401
Unadjusted period prevalence (%) 0.17 0.17 0.18
Median age at first event (years) 0.00 0.00 0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
915
Matched controls
8172
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
16.5
267.4
272
204
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
2853.3
260.6
249
*
P07.3
ICD-10 Finland
Other preterm infants
15.2
242.7
257
205
WX722
NOMESCO Finland
PEEP
22.4
158.5
130
60
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
+∞
130.2
127
*
P21.1
ICD-10 Finland
Mild and moderate birth asphyxia
+∞
118.6
116
*
P22.9
ICD-10 Finland
Respiratory distress of newborn, unspecified
+∞
117.6
115
*
P27.1
ICD-10 Finland
Bronchopulmonary dysplasia originating in the perinatal period
706.1
72.1
73
*
P59.0
ICD-10 Finland
Neonatal jaundice associated with preterm delivery
12.2
72.1
79
63
P21.0
ICD-10 Finland
Severe birth asphyxia
+∞
71.9
71
*
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
5.3
53.7
123
234
P07.2
ICD-10 Finland
Extreme immaturity
88.7
49.0
56
6
P29.30
ICD-10 Finland
Delayed closure of the ductus arteriosus
+∞
48.3
48
*
P22.8
ICD-10 Finland
Other respiratory distress of newborn
235.9
47.3
50
*
WX882
NOMESCO Finland
High dependency care
3.4
41.6
177
533
602
Kela drug reimbursment
Children's severe malnutrition
4.8
41.4
104
213
P25.1
ICD-10 Finland
Pneumothorax originating in the perinatal period
+∞
40.2
40
*
P36.90
ICD-10 Finland
Suspected bacterial sepsis of newborn
8.6
37.8
52
57
WX730
NOMESCO Finland
Conventional respirator
10.9
35.5
41
35
P39.9
ICD-10 Finland
Infection specific to the perinatal period, unspecified
9.2
35.2
46
47
P70.4
ICD-10 Finland
Other neonatal hypoglycaemia
5.4
34.9
74
130
P01.5
ICD-10 Finland
Fetus and newborn affected by multiple pregnancy
10.7
33.3
39
34
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.6
31.6
227
908
P29.31
ICD-10 Finland
Persistent fetal circulation
+∞
31.1
31
*
P29.9
ICD-10 Finland
Cardiovascular disorder originating in the perinatal period, unspecified
+∞
31.1
31
*
P70.0
ICD-10 Finland
Syndrome of infant of mother with gestational diabetes
7.1
29.3
47
62
P28.4
ICD-10 Finland
Other apnoea of newborn
+∞
29.1
29
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
28.1
180
676
J45.1
ICD-10 Finland
Nonallergic asthma
2.8
27.9
166
599
P24.0
ICD-10 Finland
Neonatal aspiration of meconium
+∞
27.1
27
*
P07.11
ICD-10 Finland
Other low birth weight 1500-1999 g
8.2
26.1
37
42
H35.1
ICD-10 Finland
Retinopathy of prematurity
89.1
25.5
29
*
R4110
NOMESCO Finland
Physiotherapy
2.2
24.6
286
1398
P07.12
ICD-10 Finland
Other low birth weight 2000-2499 g
6.0
24.4
46
72
F82
ICD-10 Finland
Specific developmental disorder of motor function
3.8
24.2
79
197
P07.02
ICD-10 Finland
Extremely low birth weight 750-999 g
+∞
23.0
23
*
P01.10
ICD-10 Finland
Fetus and newborn affected by premature rupture of membranes 1-7 days before delivery
8.0
23.0
33
38
P70.1
ICD-10 Finland
Syndrome of infant of a diabetic mother
8.4
21.6
30
33
WW804
NOMESCO Finland
Transfer from treating institution to higher-Level care, accompanied by doctor
7.2
21.2
33
42
P07.10
ICD-10 Finland
Other low birth weight 1000-1499 g
25.1
21.1
30
11
Z3231
NOMESCO Finland
Registered nurse
1.9
19.9
379
2187
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
19.3
172
745
XG413
NOMESCO Finland
Spirometry with oscillometry
4.1
18.6
54
123
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.6
18.4
118
438
P21.9
ICD-10 Finland
Birth asphyxia, unspecified
+∞
18.0
18
*
P05.1
ICD-10 Finland
Small for gestational age
5.8
17.8
34
54
Z2446
NOMESCO Finland
Social worker
2.1
17.5
202
969
Z3226
NOMESCO Finland
Physiotherapist
2.0
17.1
249
1297
P05.0
ICD-10 Finland
Light for gestational age
7.6
16.8
25
30
P07.01
ICD-10 Finland
Extremely low birth weight 500-749 g
163.8
16.8
18
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.7
15.7
89
310
Z2221
NOMESCO Finland
Medical doctor
1.9
15.6
252
1356
P00.0
ICD-10 Finland
Fetus and newborn affected by maternal hypertensive disorders
5.8
15.2
29
46
P25.2
ICD-10 Finland
Pneumomediastinum originating in the perinatal period
+∞
15.0
15
*
P20.1
ICD-10 Finland
Intrauterine hypoxia first noted during labour and delivery
+∞
15.0
15
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
14.8
217
1127
P07.1
ICD-10 Finland
Other low birth weight
23.9
14.7
21
8
P02.1
ICD-10 Finland
Fetus and newborn affected by other forms of placental separation and haemorrhage
40.9
14.3
18
*
J21.90
ICD-10 Finland
Acute obstructive bronchitis in children
2.5
14.1
95
360
JAB00
NOMESCO Finland
Division and ligature of inguinal hernia sac
3.7
14.0
47
119
FDE00
NOMESCO Finland
Closure of patent ductus arteriosus
136.1
13.8
15
*
R62.0
ICD-10 Finland
Delayed milestone
2.5
13.4
94
363
P23.9
ICD-10 Finland
Congenital pneumonia, unspecified
+∞
13.0
13
*
R03BA02
ATC
budesonide; inhalant
1.9
13.0
184
941
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
3.4
12.8
47
127
F80.1
ICD-10 Finland
Expressive language disorder
3.1
12.7
57
174
Q25.0
ICD-10 Finland
Patent ductus arteriosus
3.8
12.5
39
94
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.8
12.3
205
1104
R03BA05
ATC
fluticasone; inhalant
1.8
12.1
258
1494
P29.8
ICD-10 Finland
Other cardiovascular disorders originating in the perinatal period
+∞
12.0
12
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.7
11.5
318
1974
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
11.4
253
1477
RT150, ,
NOMESCO Finland
3.6
11.4
38
96
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
11.4
172
896
TAW99
NOMESCO Finland
Other minor neurosurgical procedure
19.3
11.3
17
8
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
11.2
213
1190
ZX114
NOMESCO Finland
Intramuscular
3.8
11.1
35
85
P29.1
ICD-10 Finland
Neonatal cardiac dysrhythmia
+∞
11.0
11
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
11.0
276
1666
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
10.7
10.5
20
17
XA800
NOMESCO Finland
Neuropsychological investigation
2.1
10.5
107
485
UGC02
NOMESCO Finland
Rigid bronchoscopy
4.3
10.3
27
57
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
3.4
10.2
37
99
R03AC02
ATC
salbutamol; inhalant
1.6
10.2
523
3739
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
2.9
10.1
50
162
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
2.8
10.0
51
168
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
2.3
9.8
80
331
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.2
9.8
40
116
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.1
9.6
101
462
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.8
9.5
148
776
WX892
NOMESCO Finland
Monitored bed care
2.2
9.4
81
343
H50.30
ICD-10 Finland
Intermittent esotropy
3.2
9.3
38
110
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.2
9.3
77
321
Z3229
NOMESCO Finland
Other healthcare associate professional
1.9
9.2
117
573
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
9.1
224
1337
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.1
9.0
92
417
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.5
8.7
350
2339
ZX108
NOMESCO Finland
Inhalation
3.9
8.5
25
58
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.6
8.3
50
180
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
1.9
8.3
114
574
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
8.2
177
1016
RK312, ,
NOMESCO Finland
6.7
8.2
20
27
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
8.2
268
1708
Z2445
NOMESCO Finland
Psychologist
1.8
8.1
137
735
P52.2
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 3, and grade 4 of fetus and newborn
24.8
8.0
11
*
WX930
NOMESCO Finland
Thepapeutic hypothermia
+∞
8.0
8
*
J21.9
ICD-10 Finland
Acute bronchiolitis, unspecified
2.0
7.9
85
393
H01AC01
ATC
somatropin; parenteral
2.5
7.9
52
196
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.1
7.8
74
325
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
7.8
169
971
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
2.2
7.8
68
290
EBA15
NOMESCO Finland
Extraction of multiple teeth
2.5
7.7
49
181
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
1.7
7.7
159
901
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
1.6
7.7
182
1069
7AA02, ,
NOMESCO Finland
30.1
7.7
10
*
P52.0
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 1, of fetus and newborn
19.9
7.6
11
5
WW805
NOMESCO Finland
Transfer from treating institution to lower-Level care, accompanied by paramedic/nurse
9.1
7.4
15
15
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.4
7.4
49
185
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.0
7.3
76
346
P08.0
ICD-10 Finland
Exceptionally large baby
13.6
7.2
12
8
H66.9
ICD-10 Finland
Otitis media, unspecified
1.5
7.1
282
1862
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
3.4
7.1
25
66
P36.3
ICD-10 Finland
Sepsis of newborn due to other and unspecified staphylococci
72.1
7.1
8
*
6BB16, ,
NOMESCO Finland
10.7
7.1
13
11
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.0
7.0
77
358
P24.1
ICD-10 Finland
Neonatal aspiration of amniotic fluid and mucus
+∞
7.0
7
*
RK520, ,
NOMESCO Finland
8.0
7.0
15
17
H65.3
ICD-10 Finland
Chronic mucoid otitis media
1.7
7.0
136
759
R56.8
ICD-10 Finland
Other and unspecified convulsions
1.9
6.9
95
477
TPH07
NOMESCO Finland
Cathetrisation of artery
1.9
6.9
97
491
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
1.9
6.9
83
399
A03FA02
ATC
cisapride; oral, rectal
2.6
6.9
40
142
A28
ICPC
Limited function/disability NOS
2.0
6.8
74
343
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
3.1
6.8
28
82
EMB30
NOMESCO Finland
Adenotomy
1.6
6.8
190
1162
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.6
6.8
164
968
ZXE00
NOMESCO Finland
One hour or less
1.5
6.8
328
2253
P03.4
ICD-10 Finland
Fetus and newborn affected by caesarean delivery
8.4
6.7
14
15
E34.31
ICD-10 Finland
Short stature, prenatal disorder
3.7
6.7
21
51
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.5
6.7
241
1558
R03DC03
ATC
montelukast; oral
1.6
6.6
163
965
G80.0
ICD-10 Finland
Spastic quadriplegic cerebral palsy
10.8
6.6
12
10
J45.8
ICD-10 Finland
Mixed asthma
2.7
6.5
34
114
FM2CE, ,
NOMESCO Finland
1.9
6.5
90
453
R03AK08
ATC
formoterol and beclometasone; inhalant
3.2
6.5
26
75
ZXD05
NOMESCO Finland
Urgent procedure
1.6
6.3
176
1073
R4120
NOMESCO Finland
Occupational therapy
1.9
6.3
75
359
WX732
NOMESCO Finland
High frequency respirator
20.3
6.3
9
*
Z00.6
ICD-10 Finland
Examination for normal comparison and control in clinical research programme
7.4
6.3
14
17
JDB10
NOMESCO Finland
Percutaneous gastrostomy
3.4
6.3
22
58
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.7
6.2
126
711
P91.02
ICD-10 Finland
Neonatal hypoxic-ischaemic encephalopathy, severe
63.1
6.1
7
*
P59.9
ICD-10 Finland
Neonatal jaundice, unspecified
2.3
6.1
45
179
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
2.2
6.1
52
220
P08.1
ICD-10 Finland
Other heavy for gestational age infants
7.0
6.1
14
18
UDQ02
NOMESCO Finland
Direct laryngoscopy
4.1
6.1
17
38
UDC00
NOMESCO Finland
Ear microscopy
1.8
6.1
91
470
G40.4
ICD-10 Finland
Other generalized epilepsy and epileptic syndromes
3.3
6.1
23
64
RD210, ,
NOMESCO Finland
1.9
6.1
74
358
WX002
NOMESCO Finland
Sedation and analgesia
1.8
6.0
87
444

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
22
50
4.00
7.68
1.0
1.0
—
—
—
0
0
223
1389
1.57
7.40
16.4
9.7
—
—
—
0
0
249
1594
1.54
7.31
17.8
9.8
7.40
7.41
ph
2.03
214
1289
249
1596
1.54
7.26
17.9
9.8
5.11
5.00
kpa
1.86
239
1555
228
1475
1.51
6.25
17.3
9.6
9.50
9.80
kpa
1.68
218
1437
232
1521
1.49
5.93
15.6
12.2
1.37
1.33
mmol/l
1.02
223
1454
153
926
1.57
5.64
1.6
1.5
199.32
426.70
u/ml
1.41
146
876
227
1499
1.47
5.55
14.4
13.4
—
—
—
0
0
414
3078
1.37
5.04
23.0
14.8
1.23
1.23
mmol/l
0.15
403
2970
213
1425
1.44
4.79
3.6
3.9
—
—
—
0
0
427
3211
1.35
4.73
10.7
11.1
—
—
—
0
0
529
4112
1.35
4.70
10.2
10.2
48.27
49.34
%
1.14
518
3994
458
3484
1.35
4.69
12.6
8.8
5.87
5.99
mmol/l
0.54
442
3291
245
1690
1.40
4.63
3.7
3.9
—
—
—
0
0
92
522
1.64
4.42
5.2
8.2
22.23
22.72
s
0.33
86
509
535
4192
1.34
4.35
10.5
10.3
36.45
35.36
%
1.25
524
4049
77
420
1.70
4.30
10.0
8.7
541.38
395.96
mg/l
0.37
61
335
237
1649
1.38
4.21
14.6
10.8
1.27
1.00
mmol/l
0.88
194
1356
68
361
1.74
4.19
1.0
1.0
11.76
8.25
mu/l
2.11
61
312
18
55
2.96
4.13
14.9
10.8
1.22
1.23
mmol/l
0.31
18
50
237
1654
1.38
4.12
15.2
10.8
7.37
7.37
ph
0.01
177
1142
37
161
2.10
4.12
1.8
2.0
—
—
—
0
0
548
4328
1.33
4.11
10.8
10.2
2.54
2.32
e9/l
1.51
478
3712
427
3265
1.32
3.99
21.9
12.9
1.23
1.23
mmol/l
0.05
410
3062
516
4053
1.31
3.95
10.7
10.5
8.57
8.44
%
0.58
498
3879
564
4486
1.32
3.94
12.2
12.0
3.44
3.46
e9/l
0.06
479
3714
514
4037
1.31
3.93
10.6
10.5
3.02
3.22
%
1.06
500
3869
314
2303
1.33
3.92
6.2
4.8
216.19
32.68
e6/l
0.51
238
1697
347
2586
1.32
3.87
8.2
8.6
—
—
—
0
0
548
4357
1.31
3.75
11.5
11.0
0.20
0.22
e9/l
0.76
477
3701
291
2123
1.33
3.74
5.9
4.6
0.19
0.25
e6/l
0.35
215
1512
23
85
2.45
3.73
1.0
1.2
—
—
—
0
0
535
4243
1.30
3.71
10.8
10.2
0.60
0.55
e9/l
2.52
454
3526
203
1405
1.37
3.68
5.3
4.1
2.33
2.99
e6/l
0.54
115
726
222
1559
1.36
3.67
3.6
3.0
2.41
2.40
mmol/l
0.01
212
1462
510
4030
1.29
3.58
10.7
10.5
0.60
0.64
%
0.72
496
3870
533
4238
1.30
3.56
10.9
10.2
0.04
0.04
e9/l
0.35
452
3523
22
85
2.34
3.28
3.2
2.5
—
—
—
0
0
206
1454
1.34
3.27
7.8
5.5
1.13
1.14
inr
0.10
174
1201
200
1407
1.34
3.24
4.9
4.0
0.68
0.90
e6/l
0.75
113
726
10
21
4.29
3.20
1.0
1.0
—
—
—
0
0
498
3956
1.27
3.20
12.6
12.3
0.00
0.01
e9/l
0.80
394
3038
16
54
2.68
3.12
7.9
3.9
99.67
167.07
umol/l
—
9
29
378
2914
1.27
3.07
4.9
3.8
67.61
67.32
nmol/l
0.08
364
2787
148
1003
1.38
3.03
6.5
7.6
1.52
1.38
%
0.94
142
953
148
1006
1.37
2.98
16.1
13.9
0.79
0.81
mmol/l
1.38
143
979
27
120
2.04
2.91
1.1
1.5
7.67
3.92
u/ml
0.57
12
78
166
1165
1.33
2.72
4.4
4.5
—
—
—
0
0
17
65
2.36
2.62
1.7
1.6
0.95
1.20
iu/ml
—
10
38
150
1044
1.34
2.60
3.9
5.3
1.34
1.85
mg/l
0.90
103
735
15
55
2.46
2.53
1.9
1.7
0.24
0.30
iu/ml
—
8
37
51
290
1.60
2.52
4.8
6.7
175.65
199.71
ng/l
0.11
46
263
44
243
1.65
2.44
2.8
2.2
—
—
—
0
0
44
243
1.65
2.44
2.8
2.2
—
—
—
0
0
44
244
1.64
2.41
2.8
2.2
—
—
—
0
0
44
244
1.64
2.41
2.8
2.2
—
—
—
0
0
133
922
1.34
2.37
2.2
1.8
—
—
—
0
0
7
15
4.19
2.35
1.0
1.1
156.14
134.13
nmol/l
—
7
15
49
282
1.58
2.32
1.0
1.0
7.29
7.26
kpa
0.04
39
239
49
282
1.58
2.32
1.0
1.0
—
—
—
0
0
49
282
1.58
2.32
1.0
1.0
-3.34
-2.13
mmol/l
0.31
11
63
11
35
2.83
2.30
1.5
1.7
1508.18
1987.00
ml
0.62
11
35
271
2067
1.24
2.29
12.5
9.2
37.06
38.42
g/l
2.93
265
1978
102
684
1.37
2.25
2.1
2.0
—
—
—
0
0
48
279
1.57
2.20
1.0
1.0
3.56
3.27
kpa
0.33
38
237
8
21
3.42
2.19
1.3
1.6
—
—
—
0
0
124
863
1.33
2.16
4.4
5.2
0.20
0.21
g/l
0.96
116
833
347
2730
1.22
2.16
7.9
5.8
126.96
52.54
e6/l
0.44
245
1775
229
1729
1.24
2.10
5.7
4.9
8.17
9.01
mmol/l
1.32
216
1646
8
22
3.27
2.10
13.5
14.6
—
—
—
0
0
294
2286
1.22
2.04
8.3
9.2
32.16
20.75
umol/l
3.03
276
2105
252
1940
1.22
1.92
3.4
3.5
2.45
2.52
mg/l
0.25
223
1755
118
831
1.31
1.91
5.3
8.8
4.96
6.38
umol/l
1.73
98
701
68
439
1.41
1.90
7.9
5.3
0.37
0.35
%
0.06
35
151
30
161
1.69
1.90
5.9
5.6
2.66
2.08
ug/l
0.61
30
161
707
6001
1.23
1.86
21.4
14.1
3.98
3.91
mmol/l
6.19
699
5825
19
89
1.93
1.85
2.1
2.8
—
—
—
0
0
99
684
1.33
1.84
21.2
15.5
105.54
105.73
mmol/l
0.15
99
684
91
626
1.33
1.75
2.5
2.4
10.38
7.25
iu/l
0.59
58
399
70
462
1.38
1.74
1.4
1.5
—
—
—
0
0
29
160
1.64
1.68
10.2
5.8
—
—
—
0
0
49
306
1.45
1.66
22.7
24.8
0.65
0.71
%
0.88
49
306
69
459
1.37
1.65
8.6
6.0
0.44
0.49
%
0.11
34
154
68
452
1.37
1.64
8.6
6.1
0.06
0.03
%
0.32
31
132
16
74
1.95
1.63
1.3
1.1
—
—
—
0
0
50
316
1.44
1.60
18.9
18.8
118.04
120.91
g/l
0.37
50
311
705
6011
1.21
1.60
21.7
14.1
139.34
139.51
mmol/l
1.32
698
5869
16
75
1.92
1.58
4.4
3.4
—
—
—
0
0
19
95
1.80
1.55
16.9
9.3
6.96
6.22
pmol/l
0.22
19
95
38
229
1.50
1.55
3.6
5.5
7.22
7.33
ph
0.65
33
185
49
312
1.43
1.52
22.9
24.5
95.64
95.67
%
0.01
49
312
193
1481
1.21
1.50
4.9
3.8
5.94
6.81
e6/l
0.47
178
1325
30
176
1.54
1.40
1.3
1.3
393.53
366.28
ug/g
0.35
19
92
6
20
2.69
1.39
1.3
1.6
—
—
—
0
0
64
434
1.34
1.39
1.7
1.2
—
—
—
0
0
282
2255
1.17
1.37
4.0
3.8
—
—
estimate
—
0
0
183
1411
1.20
1.36
4.7
3.5
555.96
597.55
mosm/kgh2o
1.29
166
1244
5
15
2.99
1.36
3.4
3.6
139.00
140.00
mmol/l
—
5
15
33
425
0.68
1.35
1.2
1.3
3.01
2.93
mmol/l
0.19
21
239
25
142
1.59
1.34
1.1
1.1
—
—
—
0
0
447
3706
1.15
1.32
7.3
6.4
135.29
120.30
u/l
2.38
422
3519
177
1368
1.19
1.28
5.5
4.4
7.38
7.38
ph
0.22
117
922
50
332
1.36
1.26
1.7
1.8
—
—
—
0
0
7
130
0.48
1.21
1.1
1.5
—
232.22
—
0
27
10
168
0.53
1.21
1.3
1.1
—
—
—
0
0
42
506
0.73
1.20
1.7
2.4
—
—
—
0
0
26
154
1.52
1.19
8.9
6.8
7.40
7.39
ph
0.27
26
154
0
31
0.00
1.17
0.0
1.5
—
42.48
—
0
25
56
385
1.32
1.14
2.9
2.5
117.61
94.94
au/ml
0.82
23
158
99
1060
0.81
1.14
1.5
1.9
—
—
—
0
0
106
1127
0.82
1.14
1.6
1.9
—
—
—
0
0
92
675
1.24
1.13
2.5
2.4
6.33
5.93
u/l
0.12
50
419
22
127
1.56
1.13
1.5
1.4
—
—
—
0
0
5
18
2.49
1.13
2.4
1.9
10.20
11.08
mmol/l
—
5
18
57
394
1.31
1.12
2.9
2.4
—
—
—
0
0
59
411
1.30
1.10
20.6
19.4
-0.89
-0.31
mmol/l
0.62
54
335
106
1123
0.82
1.10
1.5
1.9
—
—
—
0
0
9
145
0.55
1.10
1.7
1.6
—
—
—
0
0
59
412
1.30
1.09
20.6
19.4
16.87
15.75
kpa
0.36
59
399
59
412
1.30
1.09
20.7
19.4
5.16
5.30
kpa
0.60
59
399
20
114
1.58
1.08
3.5
2.1
5.06
6.59
mmol/l
2.17
15
98
32
203
1.42
1.07
1.7
1.6
0.17
0.25
nmol/l
1.37
25
161
75
542
1.26
1.06
2.7
2.0
178.62
161.49
u/ml
0.16
36
249
105
1108
0.83
1.06
1.6
1.9
—
—
—
0
0
91
675
1.23
1.03
2.3
1.7
—
—
—
0
0
55
384
1.30
1.03
2.2
1.9
0.00
0.02
estimate
0.50
14
105
119
907
1.20
1.03
2.3
2.3
78.35
85.56
ng/l
0.03
48
331
106
1114
0.83
1.02
1.5
1.9
—
—
—
0
0
59
416
1.29
1.02
20.7
19.3
7.38
7.38
ph
0.08
20
133
62
441
1.27
1.01
9.3
6.0
0.04
0.04
%
0.07
28
134
17
95
1.61
1.00
1.1
1.1
27.42
33.99
iu/ml
0.32
17
95
196
1562
1.15
0.99
1.8
1.6
101.64
96.93
pmol/l
0.69
97
824
51
355
1.30
0.98
1.4
1.7
—
—
—
0
0
201
1607
1.15
0.97
2.0
2.0
1.27
1.19
mmol/l
0.72
186
1490
99
746
1.21
0.97
4.5
5.6
62.68
64.26
e9/l
0.13
61
447
7
32
1.96
0.97
1.4
2.7
29.00
21.23
ug/min
—
7
22
22
133
1.49
0.95
2.9
2.7
—
2.75
—
0
8
457
3851
1.12
0.95
5.5
4.1
6.33
210.71
e6/l
—
6
51
86
914
0.82
0.94
1.5
2.0
—
—
—
0
0
17
97
1.58
0.94
7.2
3.4
—
—
—
0
0
35
233
1.36
0.92
1.5
1.9
—
—
—
0
0
5
93
0.48
0.90
11.8
7.8
12.06
9.80
mg/l
—
5
80
7
114
0.54
0.89
1.3
1.5
5.50
9.84
u/l
—
7
105
6
26
2.07
0.89
3.3
3.7
5.10
4.49
mmol/l
—
6
26
29
350
0.73
0.88
1.1
1.0
—
—
—
0
0
82
614
1.21
0.87
3.9
4.4
81.91
96.93
mg/l
0.16
65
523
18
236
0.67
0.87
1.1
1.4
—
—
—
0
0
184
1478
1.14
0.84
8.4
5.2
—
—
—
0
0
6
28
1.92
0.83
1.3
1.0
—
—
—
0
0
739
6430
1.14
0.81
14.1
11.2
56.89
59.32
umol/l
2.12
728
6327
29
192
1.36
0.80
1.2
1.1
—
—
—
0
0
8
42
1.71
0.80
1.3
1.4
—
—
—
0
0
8
42
1.71
0.80
1.0
1.1
—
—
nmol/l
—
0
0
8
43
1.67
0.78
2.9
6.3
266.75
215.77
ug/l
—
8
43
12
66
1.63
0.77
1.2
1.3
93.75
126.21
pmol/l
1.26
12
66
44
312
1.27
0.77
1.3
1.6
1541.84
1046.70
nmol/l
2.21
32
247
174
1401
1.13
0.77
1.3
1.3
—
—
—
0
0
80
607
1.19
0.76
4.2
4.8
183.49
6.20
mg/mmol
0.51
64
508
141
1407
0.88
0.74
2.0
2.0
—
—
—
0
0
10
53
1.69
0.73
2.8
2.6
23.92
18.64
umol/l
—
10
53
93
718
1.17
0.73
1.2
1.2
7.01
6.30
u/ml
0.16
70
538
5
23
1.95
0.71
2.6
1.6
208.40
167.61
nmol/l
—
5
23
359
3024
1.10
0.70
1.8
1.8
1.47
1.54
g/l
0.52
187
1658
9
52
1.55
0.69
3.2
2.2
32.33
32.08
pg
—
9
52
91
707
1.17
0.67
1.2
1.2
0.82
1.21
u/ml
0.45
63
493
87
674
1.17
0.67
2.9
2.4
3.97
4.15
e9/l
0.22
80
607
754
6590
1.12
0.67
21.9
16.8
13.24
13.08
%
3.09
745
6496
5
25
1.79
0.66
1.0
1.4
28.60
28.72
s
—
5
25
39
430
0.80
0.65
1.2
1.4
—
—
—
0
0
224
2158
0.90
0.65
2.2
2.3
—
—
—
0
0
5
26
1.72
0.63
2.2
2.0
—
—
—
0
0
131
1051
1.13
0.63
1.7
1.5
19.97
18.62
nmol/l
0.55
117
959
11
63
1.57
0.63
1.1
1.2
0.47
0.42
nmol/l
0.29
11
63
19
123
1.39
0.62
11.1
7.4
5.01
4.91
kpa
0.21
19
123
19
123
1.39
0.62
8.9
7.4
9.36
9.40
kpa
0.03
19
123
19
123
1.39
0.62
11.1
7.4
2.40
1.30
mmol/l
0.92
14
62
175
1430
1.11
0.62
5.6
3.6
0.00
0.00
estimate
0.50
56
498
193
1586
1.11
0.62
3.6
2.6
—
—
—
0
0
15
93
1.45
0.61
18.5
4.4
1.51
1.37
%
0.21
15
86
5
27
1.66
0.60
1.8
1.2
—
—
—
0
0
378
3215
1.09
0.58
1.9
2.0
1.69
3.50
u/ml
2.29
71
604
36
260
1.25
0.58
9.4
6.1
1.24
1.23
mmol/l
0.57
30
234
6
31
1.73
0.58
1.5
4.8
13.67
34.42
u/l
—
6
31
99
785
1.14
0.58
3.3
3.9
1355.15
1295.93
ng/l
0.04
60
425
5
81
0.55
0.56
1.8
2.2
—
—
—
0
0
68
526
1.17
0.56
1.7
1.4
—
—
—
0
0
771
6766
1.11
0.55
20.4
16.1
335.21
334.83
g/l
0.53
766
6706
6
34
1.58
0.54
2.2
2.3
2.08
2.41
nmol/l
—
6
34
37
271
1.23
0.54
1.4
1.6
7.96
11.53
u/ml
0.19
24
184
13
81
1.44
0.53
17.5
4.3
0.87
0.94
%
0.22
13
74
78
787
0.87
0.51
1.5
2.4
—
—
—
0
0
421
3910
0.93
0.51
3.8
2.9
1.36
1.40
mmol/l
1.59
401
3718
97
776
1.13
0.51
1.2
1.3
2.98
3.30
u/ml
0.08
70
550
16
105
1.37
0.50
1.1
3.2
3.81
2.93
ug/l
—
7
52
760
6673
1.10
0.50
11.5
8.3
—
—
—
0
0
7
40
1.57
0.49
1.0
1.1
—
—
—
0
0
39
291
1.21
0.49
1.2
1.6
4.87
3.05
u/ml
0.30
28
209
15
98
1.37
0.49
1.4
2.3
—
—
—
0
0
70
550
1.15
0.48
1.8
1.9
2.43
2.41
mmol/l
0.88
59
470
17
114
1.34
0.48
3.4
3.2
37.48
35.27
mmol/l
0.14
17
114
21
146
1.29
0.47
2.2
2.4
291.47
294.16
mosm/kgh2o
0.43
15
108
32
345
0.82
0.47
1.6
1.6
0.07
0.18
mg/l
—
7
143
37
276
1.21
0.47
1.1
1.2
—
—
—
0
0
10
127
0.70
0.46
1.1
1.1
—
—
—
0
0
11
69
1.43
0.44
1.7
1.2
—
—
—
0
0
444
3833
1.07
0.43
4.3
3.7
64.43
53.84
ug/l
0.29
425
3687
10
62
1.45
0.42
1.3
1.2
—
—
—
0
0
30
222
1.21
0.42
1.3
1.3
1.01
1.92
u/ml
0.36
22
153
17
117
1.30
0.42
1.1
1.0
—
—
—
0
0
16
184
0.77
0.41
1.7
2.4
—
63.64
—
0
22
353
3277
0.94
0.41
4.0
5.0
24.57
26.62
u/l
0.67
342
3162
8
53
1.35
0.41
8.6
6.2
—
—
—
0
0
87
704
1.11
0.40
1.2
1.2
6.46
3.48
u/ml
0.70
68
510
32
240
1.20
0.40
4.3
3.6
0.46
0.39
e9/l
0.32
22
141
8
54
1.33
0.40
1.0
1.1
—
—
—
0
0
860
7616
1.14
0.40
24.9
19.4
39.61
40.22
%
0.71
851
7527
5
31
1.44
0.39
1.2
1.5
118.60
134.35
mmol/24h
—
5
31
0
17
0.00
0.39
0.0
4.3
—
0.44
—
0
17
0
17
0.00
0.39
0.0
2.3
—
—
—
0
0
67
536
1.13
0.38
1.5
1.5
549.78
13987937.02
pmol/l
0.50
59
479
25
184
1.22
0.38
2.6
2.7
—
—
—
0
0
8
103
0.69
0.37
1.0
1.1
—
—
—
0
0
33
251
1.18
0.36
5.0
3.5
1606.44
1520.10
e6/l
0.14
27
167
157
1492
0.93
0.36
1.8
1.8
—
—
—
0
0
859
7612
1.13
0.35
22.9
17.9
85.85
86.18
fl
1.13
850
7524
18
199
0.80
0.35
39.6
22.3
11.49
11.42
%
0.04
18
199
768
6773
1.08
0.35
15.5
12.1
22.28
23.33
mg/l
0.39
570
4821
28
211
1.19
0.34
1.4
1.3
1.64
20.50
u/ml
1.04
22
172
6
40
1.34
0.34
7.7
2.9
3.75
3.86
mmol/l
—
6
40
14
97
1.29
0.34
2.1
1.9
156.45
162.93
mu/l
0.02
14
89
860
7624
1.12
0.33
22.9
18.0
7.12
6.88
e9/l
1.29
824
7277
859
7616
1.12
0.32
22.9
17.9
4.62
4.63
e12/l
0.36
824
7267
859
7616
1.12
0.32
22.9
17.9
28.89
28.96
pg
0.50
850
7528
29
302
0.85
0.32
1.2
1.3
—
—
—
0
0
13
90
1.29
0.32
2.0
2.1
20.40
18.92
nmol/l
—
5
24
29
301
0.86
0.31
1.2
1.3
—
—
—
0
0
35
272
1.16
0.31
27.2
23.8
15.67
15.67
%
0.01
35
266
593
5198
1.05
0.30
4.0
3.8
14.65
14.42
pmol/l
1.36
548
4674
31
239
1.16
0.30
4.4
3.4
515.13
573.13
e6/l
0.28
24
153
7
49
1.28
0.30
1.0
1.1
—
—
—
0
0
858
7610
1.11
0.30
23.1
18.0
275.08
271.99
e9/l
0.63
824
7284
12
83
1.30
0.29
1.1
1.0
—
—
—
0
0
448
4100
0.95
0.29
2.9
2.5
5.35
5.32
mmol/l
0.20
414
3800
859
7620
1.11
0.29
23.4
18.3
133.06
133.63
g/l
0.55
850
7536
43
342
1.13
0.29
1.2
1.2
—
—
—
0
0
56
453
1.11
0.28
1.2
1.1
—
—
—
0
0
437
3999
0.95
0.28
3.8
3.1
4.25
4.28
mmol/l
0.22
415
3832
419
3647
1.05
0.28
4.2
3.4
35.02
35.45
mmol/mol
0.42
399
3466
233
1998
1.06
0.28
4.1
3.1
—
0.14
—
0
7
62
505
1.10
0.28
1.1
1.1
11.32
6.38
u/ml
0.85
47
346
70
575
1.09
0.27
2.6
2.3
9.50
8.45
nmol/l
0.35
64
519
252
2168
1.05
0.27
1.6
1.6
—
—
—
0
0
8
58
1.23
0.27
1.8
1.4
0.58
0.57
e9/l
—
8
58
47
378
1.12
0.27
21.4
14.5
0.65
0.61
%
0.36
47
378
45
361
1.12
0.27
1.3
1.3
223.17
201.60
miu/ml
0.16
27
160
62
604
0.91
0.27
1.5
1.5
—
—
—
0
0
69
567
1.09
0.27
2.0
2.5
25.67
29.35
u/l
1.10
58
452
28
217
1.16
0.27
4.7
3.9
7.72
7.60
index
0.01
18
140
430
3932
0.96
0.27
3.8
3.0
2.63
2.56
mmol/l
0.96
410
3737
354
3073
1.05
0.26
5.6
3.7
20.15
0.00
estimate
0.49
61
518
58
473
1.10
0.26
1.1
1.1
14.26
10.57
u/ml
0.42
39
308
31
243
1.14
0.26
4.5
3.4
299.83
179.47
e6/l
0.87
24
157
40
398
0.89
0.25
1.9
1.9
6.05
6.37
ph
1.99
29
258
53
432
1.10
0.24
5.0
3.9
—
—
—
0
0
16
170
0.84
0.23
1.0
1.1
0.86
0.81
g/l
0.43
16
170
72
691
0.92
0.23
1.2
1.2
3.18
7.12
u/ml
0.79
22
193
353
3073
1.04
0.23
5.6
3.8
0.00
0.00
estimate
-0.00
62
520
160
1493
0.95
0.23
4.4
3.0
0.00
0.02
estimate
0.50
48
428
5
35
1.28
0.23
22.2
14.3
631.40
802.00
nmol/l
—
5
35
16
169
0.84
0.22
1.0
1.0
1.51
1.48
g/l
0.13
16
169
0
9
0.00
0.21
0.0
2.7
—
—
—
0
0
0
9
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
151
1291
1.05
0.21
4.1
3.0
50.26
57.29
u/l
1.47
140
1212
651
5744
1.04
0.21
4.7
4.3
2.12
1.97
mu/l
2.39
629
5478
0
11
0.00
0.21
0.0
1.0
—
14.42
—
0
11
152
1416
0.95
0.21
2.1
1.8
—
—
—
0
0
0
12
0.00
0.20
0.0
1.7
—
0.00
—
0
12
0
12
0.00
0.20
0.0
1.8
—
11.17
—
0
12
0
12
0.00
0.20
0.0
3.4
—
—
—
0
0
0
12
0.00
0.20
0.0
1.2
—
—
—
0
0
0
12
0.00
0.20
0.0
1.4
—
44.84
—
0
7
15
158
0.85
0.20
2.0
1.5
—
—
—
0
0
349
3045
1.04
0.20
5.6
3.7
0.00
0.00
estimate
-0.00
61
534
9
102
0.79
0.20
1.0
1.1
—
—
—
0
0
17
176
0.86
0.19
1.6
2.1
—
—
—
0
0
36
292
1.11
0.19
5.2
3.8
675.75
394.08
mg/l
0.79
36
287
710
6282
1.04
0.19
10.9
10.1
27.88
24.71
u/l
1.12
693
6115
79
747
0.94
0.18
1.2
1.2
14.49
19.88
iu/ml
0.57
17
134
7
52
1.20
0.18
1.0
1.5
—
—
—
0
0
7
52
1.20
0.18
1.0
1.5
—
—
—
0
0
7
52
1.20
0.18
1.0
1.5
—
—
—
0
0
118
1008
1.05
0.18
1.4
1.4
47.86
325.90
titre
—
7
40
22
221
0.89
0.17
1.0
1.1
9.63
16.83
u/ml
—
6
33
20
158
1.13
0.16
4.4
4.3
—
—
—
0
0
11
82
1.20
0.16
11.5
6.0
—
—
—
0
0
15
116
1.16
0.15
10.7
4.3
23.67
22.97
mmol/l
0.30
15
111
60
567
0.94
0.14
1.8
1.6
338.23
362.80
mu/l
0.25
55
527
8
88
0.81
0.14
1.0
1.1
462.88
212.98
mg/l
—
8
83
33
318
0.92
0.13
1.1
1.1
—
—
—
0
0
15
151
0.89
0.12
1.9
1.5
1.41
1.24
mm
—
10
112
12
123
0.87
0.12
3.8
2.7
4.78
4.87
u/ml
—
7
56
19
188
0.90
0.12
1.9
1.9
1.79
4.10
iu/l
—
8
75
16
160
0.89
0.12
1.9
1.5
—
—
—
0
0
14
110
1.14
0.12
6.9
4.7
0.57
0.65
index
0.11
14
110
23
188
1.10
0.11
2.8
2.1
0.00
0.00
estimate
—
10
82
19
154
1.10
0.11
1.7
1.3
—
—
—
0
0
23
222
0.92
0.10
1.0
1.1
2.70
7.61
eliau/ml
—
6
60
72
667
0.96
0.09
1.5
1.3
214.82
156.94
u/ml
0.35
17
197
14
112
1.12
0.09
3.1
4.4
2.06
3.21
%
—
5
45
6
48
1.12
0.09
1.2
1.2
—
—
—
0
0
6
49
1.09
0.09
1.0
1.2
—
—
—
0
0
87
801
0.97
0.09
2.4
2.5
8624.85
7305.84
u/l
0.08
21
216
403
3563
1.02
0.08
3.4
2.8
1.09
1.07
mmol/l
0.25
386
3388
27
257
0.94
0.08
1.1
1.4
—
—
—
0
0
24
229
0.93
0.08
1.1
1.6
—
12.01
—
0
7
13
128
0.91
0.07
1.0
1.1
—
—
—
0
0
6
67
0.80
0.07
1.0
1.1
—
—
—
0
0
51
438
1.04
0.07
1.1
1.1
1.22
0.69
u/ml
0.24
29
221
8
68
1.05
0.07
13.0
4.4
4.60
5.09
kpa
—
8
68
34
319
0.95
0.07
1.1
1.2
—
—
—
0
0
19
182
0.93
0.07
1.6
1.5
—
—
—
0
0
8
85
0.84
0.06
1.3
1.4
—
—
—
0
0
229
2019
1.02
0.06
4.9
3.1
0.00
0.00
estimate
0.50
47
421
67
616
0.97
0.06
2.0
2.1
—
—
—
0
0
14
115
1.09
0.06
1.1
1.3
—
—
—
0
0
33
282
1.05
0.05
5.5
3.9
150.44
222.66
e6/l
0.24
25
199
11
89
1.11
0.05
1.5
1.9
35.17
21.88
mg/l
—
6
49
22
186
1.06
0.05
1.1
1.4
—
—
—
0
0
119
1080
0.98
0.05
1.6
1.6
—
—
—
0
0
29
249
1.04
0.04
1.4
1.2
—
—
—
0
0
121
1066
1.02
0.04
2.2
1.7
—
—
—
0
0
31
267
1.04
0.03
5.7
4.1
—
—
—
0
0
179
1583
1.01
0.03
4.8
2.9
1.05
3.19
kg/l
0.78
122
936
295
2619
1.01
0.03
4.9
3.5
6.40
6.36
ph
0.20
143
1192
148
1334
0.99
0.02
1.9
1.6
—
—
—
0
0
179
1587
1.01
0.02
3.1
3.6
108.19
95.85
ug/g
0.11
149
1285
24
222
0.96
0.02
6.9
4.6
—
—
—
0
0
18
168
0.96
0.02
1.6
1.2
—
1.13
—
0
9
104
920
1.01
0.02
1.6
1.7
826.67
465.22
titre
0.40
12
138
21
181
1.04
0.01
4.9
3.7
—
—
—
0
0
43
377
1.02
0.01
1.0
1.2
—
—
—
0
0
10
95
0.94
0.01
1.1
1.1
—
291.37
—
0
27
50
453
0.98
0.01
2.2
2.1
14.18
11.95
au/ml
—
5
36
16
143
1.00
0.00
4.9
3.8
3.60
3.26
e9/l
0.34
16
143
11
101
0.97
0.00
1.3
1.7
—
—
—
0
0
32
282
1.01
0.00
5.6
3.9
37.78
8.84
e6/l
0.37
23
191
12
111
0.97
0.00
1.1
1.3
—
—
—
0
0
17
148
1.03
0.00
1.2
1.4
—
—
—
0
0
35
315
0.99
0.00
3.1
2.9
52.15
53.06
%
0.15
35
315
96
859
1.00
0.00
2.4
2.4
—
—
—
0
0
9
81
0.99
0.00
1.1
1.3
9.61
9.08
umol/l
—
9
81
5
44
1.01
0.00
1.0
1.1
—
—
—
0
0
6
60
0.89
-0.00
2.0
2.5
98.17
97.82
g/l
—
6
60
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.0
—
—
—
0
0
7
63
0.99
-0.00
1.6
2.0
—
—
—
0
0
6
58
0.92
-0.00
1.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
47
0.95
-0.00
3.4
2.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
683.40
—
0
5
9
82
0.98
-0.00
1.1
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
—
—
0
0
5
53
0.84
-0.00
1.6
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
1492.67
—
0
6
5
49
0.91
-0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
74.67
—
0
6
9
82
0.98
-0.00
1.2
1.1
—
—
—
0
0
6
60
0.89
-0.00
4.2
3.0
—
—
—
0
0
8
77
0.93
-0.00
1.5
2.8
—
248.70
—
0
21
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
66.81
—
0
7
6
62
0.86
-0.00
6.7
4.5
14.48
11.13
mg/l
—
6
56
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
7
63
0.99
-0.00
1.7
3.1
26.73
27.83
ug/l
—
7
57
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD and mortality.

Females

Parameter HR [95% CI] p-value
P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD 1.961 [1.64, 2.34] < 0.001
Birth year 0.997 [0.99, 1.01] 0.451

During the follow-up period (1.1.1998 — 31.12.2019), 199 out of 29349 females with P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD died.

Males

Parameter HR [95% CI] p-value
P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD 2.368 [2.05, 2.74] < 0.001
Birth year 0.988 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 279 out of 38142 males with P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD died.

Mortality risk

Mortality risk for people of age

years, who have P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD.

N-year risk Females Males
1 0.176% 0.425%
5 1.096% 2.92%
10 2.92% 7.072%
15 5.676% 12.871%
20 10.052% 21.298%

Relationships between endpoints

Index endpoint: P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD – Respiratory and cardiovascular disorders specific to the perinatal period

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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