newborn respiratory distress syndrome: Infant acute respiratory distress syndrome is a lung disorder that affects premature infants caused by developmental insufficiency of surfactant production and structural immaturity of the lungs. The symptoms usually appear shortly after birth and may include tachypnea, tachycardia, chest wall retractions (recession), expiratory grunting, nasal flaring and cyanosis during breathing efforts.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
563 |
4. Check minimum number of eventsNone |
563 |
5. Include endpointsNone |
563 |
6. Filter based on genotype QC (FinnGen only) |
495 |
Control definitions (FinnGen only)
- Control exclude
- P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- P2
- Name in latin
- Dyspnoea neonatalis
Similar endpoints
↥List of similar endpoints to
Respiratory distress of newborn
based on the number of shared cases.
Similar with more cases:
- Respiratory and cardiovascular disorders specific to the perinatal period
- Certain conditions originating in the perinatal period
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 49038 | 21114 | 27923 |
| Only index persons | 18039 | 7483 | 10556 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.70 | 0.60 | 0.78 |
| Only index persons | 0.35 | 0.28 | 0.40 |
| Median age at first event (years) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 495 | 254 | 241 |
| Unadjusted period prevalence (%) | 0.10 | 0.09 | 0.11 |
| Median age at first event (years) | 0.00 | 0.00 | 0.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 523
- Matched controls
- 4845
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
4006.5
284.3
254
*
P07.3
ICD-10 Finland
Other preterm infants
20.1
207.5
194
138
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
13.7
139.2
156
146
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
+∞
136.2
128
*
WX722
NOMESCO Finland
PEEP
22.6
135.9
111
57
P22.9
ICD-10 Finland
Respiratory distress of newborn, unspecified
+∞
122.8
116
*
P59.0
ICD-10 Finland
Neonatal jaundice associated with preterm delivery
14.6
64.4
63
45
P22.8
ICD-10 Finland
Other respiratory distress of newborn
266.8
50.5
52
*
P07.2
ICD-10 Finland
Extreme immaturity
200.2
38.2
40
*
P27.1
ICD-10 Finland
Bronchopulmonary dysplasia originating in the perinatal period
+∞
35.9
35
*
P29.30
ICD-10 Finland
Delayed closure of the ductus arteriosus
+∞
33.8
33
*
WX882
NOMESCO Finland
High dependency care
3.5
30.8
137
451
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
4.3
30.3
90
223
P01.5
ICD-10 Finland
Fetus and newborn affected by multiple pregnancy
11.7
28.4
31
26
602
Kela drug reimbursment
Children's severe malnutrition
4.5
26.2
71
163
P39.9
ICD-10 Finland
Infection specific to the perinatal period, unspecified
10.5
24.8
29
27
P07.11
ICD-10 Finland
Other low birth weight 1500-1999 g
10.1
24.2
29
28
P70.0
ICD-10 Finland
Syndrome of infant of mother with gestational diabetes
7.0
21.8
35
49
P21.1
ICD-10 Finland
Mild and moderate birth asphyxia
+∞
21.4
21
*
P36.90
ICD-10 Finland
Suspected bacterial sepsis of newborn
7.5
21.0
32
42
WX730
NOMESCO Finland
Conventional respirator
8.7
20.3
27
30
P07.10
ICD-10 Finland
Other low birth weight 1000-1499 g
36.1
20.2
26
7
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.8
19.8
127
504
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.7
19.4
130
528
P07.02
ICD-10 Finland
Extremely low birth weight 750-999 g
+∞
19.3
19
*
H35.1
ICD-10 Finland
Retinopathy of prematurity
182.3
18.1
19
*
F82
ICD-10 Finland
Specific developmental disorder of motor function
3.8
17.2
56
147
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.5
16.2
126
545
R4110
NOMESCO Finland
Physiotherapy
2.2
16.1
186
958
P07.12
ICD-10 Finland
Other low birth weight 2000-2499 g
5.4
15.4
32
58
P29.31
ICD-10 Finland
Persistent fetal circulation
+∞
15.2
15
*
P70.4
ICD-10 Finland
Other neonatal hypoglycaemia
4.3
14.8
40
91
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.8
14.7
81
294
J45.1
ICD-10 Finland
Nonallergic asthma
2.6
14.2
98
399
WW804
NOMESCO Finland
Transfer from treating institution to higher-Level care, accompanied by doctor
6.0
13.7
25
40
P00.0
ICD-10 Finland
Fetus and newborn affected by maternal hypertensive disorders
6.5
13.6
23
34
P07.1
ICD-10 Finland
Other low birth weight
71.5
13.2
15
*
P07.01
ICD-10 Finland
Extremely low birth weight 500-749 g
133.0
13.1
14
*
P05.1
ICD-10 Finland
Small for gestational age
5.8
12.6
24
40
F80.1
ICD-10 Finland
Expressive language disorder
3.5
11.7
43
122
FDE00
NOMESCO Finland
Closure of patent ductus arteriosus
113.6
11.1
12
*
Z3231
NOMESCO Finland
Registered nurse
1.9
10.8
235
1473
P01.10
ICD-10 Finland
Fetus and newborn affected by premature rupture of membranes 1-7 days before delivery
8.5
10.7
23
26
XG413
NOMESCO Finland
Spirometry with oscillometry
3.5
10.5
38
107
P25.1
ICD-10 Finland
Pneumothorax originating in the perinatal period
+∞
10.1
10
*
Z3226
NOMESCO Finland
Physiotherapist
1.9
10.1
161
907
Z2221
NOMESCO Finland
Medical doctor
2.0
10.1
150
826
P05.0
ICD-10 Finland
Light for gestational age
9.1
9.3
19
20
H50.30
ICD-10 Finland
Intermittent esotropy
3.7
8.9
29
76
P70.1
ICD-10 Finland
Syndrome of infant of a diabetic mother
8.3
8.9
19
22
JAB00
NOMESCO Finland
Division and ligature of inguinal hernia sac
3.6
8.7
29
77
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.6
8.7
55
213
R03BA05
ATC
fluticasone; inhalant
1.8
8.5
165
983
P02.1
ICD-10 Finland
Fetus and newborn affected by other forms of placental separation and haemorrhage
47.1
8.4
10
*
P21.0
ICD-10 Finland
Severe birth asphyxia
+∞
8.1
8
*
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
13.7
7.9
13
9
TAW99
NOMESCO Finland
Other minor neurosurgical procedure
16.2
7.8
12
7
Z2446
NOMESCO Finland
Social worker
1.9
7.8
126
707
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
7.7
135
776
RT150, ,
NOMESCO Finland
3.5
7.5
26
71
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
7.4
142
836
RK312, ,
NOMESCO Finland
7.0
7.3
17
23
R62.0
ICD-10 Finland
Delayed milestone
2.2
7.3
65
294
EMB30
NOMESCO Finland
Adenotomy
1.8
7.2
119
669
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.8
7.1
133
777
WW805
NOMESCO Finland
Transfer from treating institution to lower-Level care, accompanied by paramedic/nurse
8.8
6.9
14
15
R03BA02
ATC
budesonide; inhalant
1.9
6.8
101
548
A03FA02
ATC
cisapride; oral, rectal
3.5
6.8
23
62
P52.0
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 1, of fetus and newborn
21.2
6.4
9
*
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
3.0
6.4
28
89
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.0
6.2
75
380
J21.9
ICD-10 Finland
Acute bronchiolitis, unspecified
2.3
6.2
48
205
WX725
NOMESCO Finland
Noninvasive ventilation
3.5
6.2
21
57
P36.3
ICD-10 Finland
Sepsis of newborn due to other and unspecified staphylococci
+∞
6.1
6
*
P28.4
ICD-10 Finland
Other apnoea of newborn
+∞
6.1
6
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
1.7
6.0
114
666
P52.2
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 3, and grade 4 of fetus and newborn
25.0
6.0
8
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
95
629
1.49
2.91
1.7
1.5
245.96
478.27
u/ml
0.82
90
590
171
1269
1.37
2.77
14.7
10.7
5.05
4.96
kpa
1.03
163
1238
170
1264
1.36
2.71
14.5
10.5
0.91
0.65
mmol/l
0.61
119
923
13
45
2.72
2.64
9.0
9.3
—
—
—
0
0
197
1506
1.34
2.60
5.7
5.4
39.99
22.26
e6/l
0.46
149
1119
184
1408
1.32
2.37
5.2
5.2
0.17
0.21
e6/l
0.34
137
1013
56
348
1.55
2.31
1.0
1.0
9.91
8.29
mu/l
0.95
51
308
68
444
1.48
2.24
11.1
10.2
44.65
49.59
ng/l
0.96
68
439
174
1337
1.31
2.15
10.6
11.2
41.40
27.11
umol/l
2.21
162
1227
130
964
1.33
2.05
4.7
4.6
2.42
2.07
e6/l
0.18
79
522
12
46
2.45
2.04
2.2
1.6
0.25
0.26
iu/ml
—
7
31
6
14
4.00
2.01
1.2
1.1
—
—
—
0
0
35
202
1.65
1.98
16.4
12.1
22.57
22.99
mmol/l
0.54
35
196
157
1207
1.29
1.90
13.6
10.4
9.42
9.83
kpa
2.05
149
1176
127
953
1.31
1.84
4.5
4.5
0.65
0.88
e6/l
0.65
75
508
5
11
4.24
1.82
2.6
1.9
208.40
190.73
nmol/l
—
5
11
13
55
2.22
1.81
1.9
1.6
0.97
1.08
iu/ml
—
8
32
193
1536
1.26
1.75
6.3
5.4
—
—
—
0
0
13
56
2.18
1.74
6.2
7.7
—
—
—
0
0
43
273
1.50
1.66
1.0
1.0
-3.12
-2.12
mmol/l
0.27
12
61
43
273
1.50
1.66
1.0
1.0
7.40
7.27
kpa
0.15
37
234
145
1125
1.27
1.61
14.8
13.2
1.39
1.37
mmol/l
0.29
140
1071
80
573
1.35
1.60
2.5
2.2
—
—
—
0
0
34
208
1.55
1.56
1.5
1.4
—
—
—
0
0
34
208
1.55
1.56
1.5
1.4
—
—
—
0
0
42
270
1.48
1.54
1.0
1.0
3.46
3.27
kpa
0.19
36
232
16
79
1.90
1.53
1.0
1.1
—
—
—
0
0
266
2219
1.22
1.51
15.9
10.8
5.77
5.99
mmol/l
0.90
256
2114
37
233
1.51
1.50
1.4
1.8
—
—
—
0
0
68
481
1.36
1.48
2.5
2.2
—
—
—
0
0
28
166
1.59
1.47
1.4
3.4
—
—
—
0
0
13
61
2.00
1.43
1.5
2.0
—
—
—
0
0
86
979
0.78
1.33
2.4
2.6
—
—
—
0
0
213
1756
1.21
1.31
5.1
4.3
68.65
67.95
nmol/l
0.15
206
1676
90
1015
0.78
1.29
2.5
2.7
—
—
—
0
0
15
235
0.58
1.28
1.3
1.3
—
—
—
0
0
11
51
2.02
1.26
6.8
3.9
121.00
169.74
umol/l
—
5
27
22
130
1.59
1.20
5.6
5.9
2.98
2.30
ug/l
0.61
22
130
40
269
1.41
1.20
2.7
2.7
98.64
93.08
au/ml
0.10
14
129
251
2116
1.19
1.19
24.4
17.6
1.23
1.23
mmol/l
0.20
246
2039
58
677
0.77
1.10
2.2
2.3
—
—
—
0
0
65
479
1.29
1.10
2.8
2.3
—
—
—
0
0
16
89
1.69
1.10
5.0
5.6
—
—
—
0
0
7
29
2.25
1.10
1.1
1.2
—
—
—
0
0
64
736
0.78
1.08
2.2
2.5
—
—
—
0
0
327
2836
1.18
1.06
13.6
13.6
3.32
3.32
e9/l
0.01
269
2293
7
31
2.11
1.04
1.1
1.3
—
—
—
0
0
7
31
2.11
1.04
1.1
1.2
0.59
0.67
ug/l
—
7
23
258
2199
1.17
1.03
22.3
15.2
1.23
1.23
mmol/l
0.05
253
2079
7
33
1.98
0.98
1.3
1.5
—
—
—
0
0
54
397
1.29
0.95
2.8
2.6
6.81
6.37
iu/l
0.12
37
225
128
1039
1.19
0.91
6.1
5.4
7.91
8.44
mmol/l
0.45
123
994
50
367
1.29
0.90
2.4
2.2
—
62.01
—
0
7
101
804
1.20
0.89
1.8
1.6
101.39
98.72
pmol/l
0.19
48
398
33
403
0.74
0.89
1.2
1.3
—
—
—
0
0
22
142
1.45
0.85
1.5
1.6
1877.35
1085.09
nmol/l
2.27
17
104
26
174
1.40
0.84
18.3
16.2
121.17
294.42
u/ml
—
6
26
6
29
1.93
0.83
3.5
7.6
219.50
239.72
ug/l
—
6
29
11
60
1.71
0.83
1.5
1.6
—
—
—
0
0
16
97
1.54
0.82
1.2
1.3
—
—
—
0
0
232
1987
1.15
0.82
1.9
1.9
1.36
1.42
g/l
0.27
122
1036
78
611
1.21
0.81
4.8
7.1
1.59
2.21
mg/l
0.62
54
459
24
160
1.41
0.80
2.2
1.3
—
—
—
0
0
252
2175
1.14
0.78
4.8
4.0
81.24
47.56
ug/l
0.68
244
2095
21
137
1.44
0.78
1.3
2.1
—
—
—
0
0
118
964
1.17
0.78
4.6
4.0
5.94
6.16
e6/l
0.08
107
856
69
538
1.22
0.76
1.5
1.5
20.10
19.92
nmol/l
0.04
63
483
14
192
0.67
0.74
1.3
1.2
3.00
2.91
mmol/l
—
9
106
7
36
1.81
0.73
1.3
1.2
—
—
—
0
0
152
1275
1.15
0.71
18.0
11.8
5.72
5.78
kpa
0.52
152
1244
21
140
1.41
0.71
7.1
3.1
—
—
—
0
0
5
24
1.94
0.71
1.0
1.4
—
—
—
0
0
151
1268
1.15
0.70
17.8
11.9
0.95
0.84
mmol/l
0.18
122
1025
5
25
1.86
0.68
1.6
5.2
13.00
33.36
u/l
—
5
25
13
79
1.54
0.68
1.4
1.3
0.93
1.64
u/ml
0.25
13
79
12
72
1.56
0.66
1.5
2.0
—
—
—
0
0
16
103
1.45
0.65
1.4
1.4
21.72
12.85
u/ml
0.33
16
96
8
118
0.62
0.65
2.5
1.6
—
—
—
0
0
72
575
1.19
0.64
7.3
10.5
5.48
6.23
umol/l
0.45
58
480
184
1837
0.89
0.62
7.6
7.1
114.57
114.10
ml/min/173m2
0.10
125
1235
0
18
0.00
0.61
0.0
1.4
—
—
—
0
0
147
1244
1.13
0.60
16.7
11.7
5.48
5.16
kpa
0.65
147
1218
55
431
1.20
0.60
2.8
2.6
4.52
5.00
u/l
0.16
32
225
32
236
1.27
0.59
2.1
1.9
—
—
—
0
0
23
162
1.33
0.59
2.1
2.0
—
—
—
0
0
11
67
1.53
0.58
1.1
1.0
—
—
—
0
0
8
50
1.49
0.57
4.4
2.0
—
—
—
0
0
228
2239
0.90
0.56
2.3
2.2
—
—
—
0
0
47
366
1.21
0.55
2.5
2.2
144.33
149.35
u/ml
0.03
24
158
174
1732
0.90
0.55
4.9
6.3
26.20
26.05
u/l
0.02
169
1671
26
189
1.29
0.54
20.4
13.2
60.40
341.37
iu/ml
—
5
27
20
241
0.76
0.54
1.3
1.3
—
—
—
0
0
30
223
1.26
0.53
26.9
27.0
0.66
0.71
%
0.49
30
223
212
1847
1.11
0.52
3.3
3.0
1.07
1.06
mmol/l
0.11
201
1768
9
59
1.42
0.52
1.9
3.3
58.44
60.32
umol/l
—
9
59
16
109
1.37
0.51
1.4
1.4
9.94
8.40
u/ml
0.09
16
101
30
225
1.25
0.50
27.1
26.8
96.31
95.91
%
0.15
30
225
7
44
1.48
0.47
1.1
1.4
94.57
125.30
pmol/l
—
7
44
234
2057
1.10
0.47
1.9
2.1
2.51
4.47
u/ml
1.21
42
347
12
79
1.42
0.46
1.2
1.1
20.96
33.51
iu/ml
0.81
12
79
53
428
1.16
0.44
2.0
2.4
13.00
43.49
ng/l
1.68
22
167
8
53
1.40
0.42
1.5
1.5
—
—
—
0
0
19
138
1.29
0.42
2.0
1.9
3.64
3.72
umol/l
0.05
19
121
13
89
1.36
0.41
2.2
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
203.12
—
0
16
12
148
0.75
0.39
1.2
1.4
—
—
—
0
0
5
33
1.41
0.38
1.4
1.4
—
—
—
0
0
9
62
1.35
0.38
1.1
1.0
—
—
—
0
0
32
348
0.84
0.38
1.2
1.3
—
—
—
0
0
18
132
1.27
0.38
6.6
4.8
74.57
86.90
ml/min/173m2
—
7
29
30
234
1.20
0.38
3.3
3.0
5.44
5.19
pmol/l
0.61
30
217
107
916
1.10
0.37
4.9
4.2
—
—
—
0
0
5
34
1.37
0.37
2.4
2.9
25.48
16.46
umol/l
—
5
34
5
34
1.37
0.37
1.8
1.1
318.80
709.06
mu/l
—
5
34
41
330
1.16
0.37
1.8
1.8
—
—
—
0
0
11
75
1.37
0.36
1.0
1.3
—
—
—
0
0
11
75
1.37
0.36
1.0
1.3
—
—
—
0
0
11
75
1.37
0.36
1.0
1.3
—
—
—
0
0
9
66
1.27
0.36
1.0
1.0
—
—
—
0
0
240
2133
1.08
0.35
7.2
6.2
151.00
142.56
u/l
0.55
228
2021
19
142
1.25
0.35
3.0
2.4
—
—
—
0
0
12
84
1.33
0.34
4.3
2.9
1.89
1.74
mmol/l
0.27
12
84
79
798
0.90
0.34
5.3
3.1
0.00
0.00
estimate
-0.00
23
225
11
76
1.35
0.34
1.0
1.3
—
—
—
0
0
30
323
0.85
0.33
1.1
1.1
1.87
0.73
u/ml
0.34
18
178
11
77
1.33
0.31
1.3
1.5
—
—
—
0
0
7
90
0.72
0.31
2.7
1.8
—
—
—
0
0
20
222
0.83
0.31
1.5
1.7
—
—
—
0
0
11
78
1.31
0.29
1.1
1.3
—
—
—
0
0
49
503
0.89
0.29
3.7
4.4
923.00
1251.26
ng/l
0.38
36
292
15
170
0.81
0.28
2.7
7.1
103.20
97.32
%
0.27
15
170
8
60
1.24
0.27
2.0
2.0
137.00
121.25
%
—
8
60
227
2176
0.94
0.27
2.7
2.3
5.38
5.28
mmol/l
0.45
209
1996
35
365
0.88
0.27
1.2
1.2
1.12
7.20
u/ml
—
9
96
203
1952
0.94
0.26
4.1
3.6
34.80
35.57
mmol/mol
0.54
193
1861
92
797
1.08
0.26
6.1
3.8
0.00
0.00
estimate
-0.00
25
268
29
235
1.15
0.26
3.3
2.2
—
—
—
0
0
413
3767
1.07
0.25
14.2
11.9
52.70
54.34
umol/l
0.81
406
3695
6
78
0.71
0.24
1.2
1.1
0.30
1.01
u/ml
—
6
78
16
176
0.84
0.23
2.3
2.3
0.42
0.46
nmol/l
0.11
16
156
5
35
1.33
0.23
1.8
1.1
71.00
74.86
%
—
5
35
31
255
1.13
0.23
2.6
3.5
13.64
17.44
mu/l
0.65
31
243
33
341
0.89
0.23
1.2
1.2
12.65
11.90
u/ml
0.05
23
225
12
90
1.24
0.22
3.5
1.6
—
—
—
0
0
7
88
0.73
0.22
2.9
2.7
—
—
—
0
0
36
369
0.90
0.22
2.1
2.5
26.97
29.30
u/l
0.36
29
286
493
4534
1.13
0.22
23.6
19.8
4.64
4.62
e12/l
0.31
472
4289
10
115
0.80
0.22
1.5
1.3
—
—
—
0
0
34
283
1.12
0.21
26.2
22.1
15.47
15.90
kpa
0.13
34
276
34
283
1.12
0.21
26.2
22.1
5.31
5.44
kpa
0.45
34
276
0
11
0.00
0.21
0.0
1.4
—
58.73
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
12
91
1.23
0.21
1.2
1.4
—
—
—
0
0
35
293
1.11
0.20
1.8
1.9
2.45
2.42
mmol/l
1.36
28
249
10
74
1.26
0.20
1.0
1.3
—
—
—
0
0
0
13
0.00
0.20
0.0
2.1
—
—
—
0
0
0
13
0.00
0.20
0.0
6.0
—
1.95
—
0
13
21
170
1.15
0.19
1.7
2.1
—
—
—
0
0
17
135
1.17
0.19
1.4
1.3
418.91
371.59
ug/g
0.68
11
75
35
356
0.90
0.19
1.1
1.2
9.52
7.22
u/ml
0.22
27
247
44
376
1.09
0.18
1.6
1.3
235.96
142.38
u/ml
—
9
95
7
54
1.20
0.18
1.0
1.0
—
—
—
0
0
11
84
1.22
0.18
5.5
4.7
0.36
0.61
index
0.67
11
84
136
1213
1.05
0.18
4.6
3.7
2.49
2.46
mg/l
0.07
124
1106
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
16
128
1.16
0.17
14.6
30.6
0.23
0.33
iu/ml
—
7
84
23
190
1.13
0.17
6.1
4.7
2.93
3.25
mmol/l
0.98
23
184
23
190
1.13
0.17
5.2
3.7
561.06
553.97
e6/l
0.02
17
120
214
2032
0.96
0.16
3.6
3.1
1.36
1.40
mmol/l
0.81
201
1942
10
111
0.83
0.16
2.1
1.4
—
—
—
0
0
29
244
1.11
0.16
3.6
2.4
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
8
66
1.12
0.16
2.1
2.1
123.00
115.11
%
—
8
66
23
237
0.89
0.16
1.4
1.2
3.34
3.13
ratio
0.29
17
142
441
4048
1.06
0.16
14.9
13.2
23.54
24.81
mg/l
0.33
316
2864
8
67
1.11
0.16
1.7
1.2
—
—
—
0
0
23
191
1.12
0.16
6.2
4.9
194.94
251.24
e6/l
0.12
17
129
9
72
1.16
0.15
1.4
1.2
—
—
—
0
0
492
4532
1.10
0.15
23.7
20.0
278.39
275.56
e9/l
0.36
473
4303
9
74
1.13
0.15
1.0
1.3
—
—
—
0
0
23
192
1.11
0.15
6.2
4.9
53.38
7.74
e6/l
0.41
16
126
23
192
1.11
0.15
5.4
3.7
371.65
179.11
e6/l
1.08
17
122
73
710
0.94
0.14
1.1
1.1
—
—
—
0
0
331
3026
1.04
0.13
4.0
3.6
14.68
14.48
pmol/l
0.77
305
2741
40
347
1.07
0.13
1.5
1.5
—
—
—
0
0
53
518
0.94
0.12
1.2
1.2
3.67
3.09
u/ml
0.10
43
386
12
97
1.15
0.11
1.2
1.3
—
21.00
—
0
5
40
393
0.94
0.11
1.2
1.2
13.25
16.51
iu/ml
—
6
75
19
160
1.10
0.10
1.5
1.3
258.59
193.29
miu/ml
0.35
13
66
22
221
0.92
0.10
1.5
1.7
11.16
11.69
u/ml
0.02
15
161
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
5
43
1.08
0.09
1.0
1.2
—
58.44
—
0
9
5
43
1.08
0.09
1.0
1.2
—
77.67
—
0
9
5
45
1.03
0.09
1.0
1.8
84.80
86.60
%
—
5
45
222
2087
0.97
0.09
3.6
3.3
4.22
4.24
mmol/l
0.11
209
2011
7
59
1.10
0.08
1.1
1.0
—
—
—
0
0
37
360
0.95
0.08
2.5
2.5
93.66
9467.22
u/l
—
5
92
11
114
0.89
0.08
1.2
1.4
—
—
—
0
0
59
566
0.96
0.07
1.2
1.3
4.23
3.03
u/ml
0.23
44
417
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
66
0.84
0.07
1.7
1.2
—
—
—
0
0
20
199
0.93
0.07
47.8
21.9
74.77
70.14
%
0.86
20
199
7
75
0.86
0.07
1.0
1.0
1.60
1.49
g/l
—
7
75
7
76
0.85
0.07
1.0
1.1
0.92
0.80
g/l
—
7
76
361
3320
1.02
0.07
4.6
4.1
2.22
2.05
mu/l
1.60
351
3167
8
84
0.88
0.07
1.6
4.5
—
—
—
0
0
8
84
0.88
0.07
1.6
4.6
—
—
—
0
0
443
4123
0.97
0.07
4.0
4.0
—
—
—
0
0
8
88
0.84
0.06
1.6
1.5
61.17
59.25
ug/l
—
8
88
30
264
1.06
0.06
37.3
18.0
0.54
0.60
%
0.45
30
264
14
119
1.09
0.06
1.0
1.2
—
—
—
0
0
218
2042
0.98
0.06
3.6
3.2
2.59
2.55
mmol/l
0.26
205
1947
20
174
1.07
0.05
1.3
1.3
1.37
2.08
u/ml
0.19
15
127
124
1130
1.02
0.05
5.3
3.2
0.00
0.00
estimate
-0.00
21
224
197
1842
0.99
0.04
5.9
3.9
0.00
0.00
estimate
-0.00
27
275
29
279
0.96
0.04
2.1
1.6
386.89
355.86
mu/l
0.18
29
262
20
177
1.05
0.03
1.7
1.9
—
—
—
0
0
56
529
0.98
0.03
1.2
1.2
5.23
5.54
u/ml
0.07
43
411
393
3630
1.01
0.02
11.5
11.0
29.86
24.66
u/l
1.15
386
3522
15
132
1.05
0.02
2.3
2.0
35.10
32.34
%
—
10
102
52
474
1.02
0.01
34.9
18.0
106.10
105.73
mmol/l
0.21
52
474
22
197
1.04
0.01
5.7
4.0
—
—
—
0
0
99
909
1.01
0.01
5.2
2.8
1.08
1.02
kg/l
0.50
68
565
23
207
1.03
0.01
1.9
2.2
—
—
—
0
0
196
1823
0.99
0.01
5.8
3.9
0.00
0.00
estimate
-0.00
26
282
14
124
1.05
0.01
2.1
1.6
—
—
—
0
0
139
1293
0.99
0.00
5.1
4.2
—
—
estimate
—
0
0
11
101
1.01
0.00
1.5
1.4
80.55
75.08
%
0.21
11
101
21
190
1.02
0.00
2.0
2.0
—
—
—
0
0
13
124
0.97
0.00
1.0
1.2
—
—
—
0
0
44
412
0.99
0.00
7.2
9.5
2627.47
1364.10
ng/l
0.67
39
355
11
106
0.96
0.00
2.5
1.9
7.94
6.18
ug/l
0.20
11
99
11
102
1.00
0.00
2.3
1.9
2.12
3.49
iu/l
—
5
40
276
2552
1.00
0.00
4.5
5.1
7.13
6.91
mm/h
0.13
267
2413
100
926
1.00
0.00
2.2
2.1
1.30
1.17
mmol/l
0.78
92
870
198
1837
1.00
0.00
5.9
3.9
45.52
0.00
estimate
0.49
27
272
13
118
1.02
0.00
3.3
4.1
430.23
442.13
ug/l
0.03
13
110
56
522
0.99
0.00
1.2
1.2
1.13
0.87
u/ml
0.20
41
387
19
171
1.03
0.00
3.0
1.5
—
—
—
0
0
19
175
1.01
0.00
1.6
1.2
—
—
—
0
0
5
46
1.01
-0.00
1.0
1.2
—
88.83
—
0
18
0
8
0.00
-0.00
0.0
1.0
—
0.71
—
0
8
7
65
1.00
-0.00
22.6
9.6
6.01
5.25
pmol/l
—
7
65
0
6
0.00
-0.00
0.0
1.0
—
1.92
—
0
6
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
13.50
—
0
8
5
46
1.01
-0.00
2.6
2.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
7.52
—
0
5
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
80
0.93
-0.00
2.9
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
6
59
0.94
-0.00
16.8
4.5
4.47
5.03
kpa
—
6
59
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
7
73
0.89
-0.00
2.4
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
65
1.00
-0.00
8.7
5.3
29.14
23.81
ug/l
—
7
65
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
5
51
0.91
-0.00
1.0
1.3
92.20
84.71
%
—
5
51
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
5
54
0.86
-0.00
1.0
1.1
—
—
—
0
0
5
47
0.99
-0.00
1.0
1.3
—
72.37
—
0
19
Mortality – FinRegistry
↥Association
Association between endpoint P16_RESPI_DISTR_NEWBO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| P16_RESPI_DISTR_NEWBO | 1.873 [1.51, 2.32] | < 0.001 |
| Birth year | 0.996 [0.99, 1.01] | 0.39 |
During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 19773 females with P16_RESPI_DISTR_NEWBO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| P16_RESPI_DISTR_NEWBO | 1.898 [1.59, 2.26] | < 0.001 |
| Birth year | 0.985 [0.97, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 164 out of 26033 males with P16_RESPI_DISTR_NEWBO died.
Mortality risk
Mortality risk for people of age
years, who have P16_RESPI_DISTR_NEWBO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.196% | 0.286% |
| 5 | 1.099% | 1.786% |
| 10 | 2.779% | 4.573% |
| 15 | 5.361% | 8.709% |
| 20 | 9.471% | 14.853% |
Relationships between endpoints
↥Index endpoint: P16_RESPI_DISTR_NEWBO – Respiratory distress of newborn
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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