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Cardiovascular disorders originating in the perinatal period

Endpoint Browser PheWeb

P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — P29
  • Cause of death: ICD-10 — P29

2 out of 7 registries used, show all original rules.

142

4. Check minimum number of events

None

142

5. Include endpoints

None

142

6. Filter based on genotype QC (FinnGen only)

120

Control definitions (FinnGen only)

Control exclude
P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P2
Name in latin
Morbositates cardiovasculares origine perinatales

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7884 3729 4154
Only index persons 4035 1874 2161
Unadjusted period prevalence (%)
Whole population 0.11 0.11 0.12
Only index persons 0.08 0.07 0.08
Median age at first event (years)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.01 0.00

-FinnGen-

Key figures

All Female Male
Number of individuals 120 70 50
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 0.00 0.00 0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
134
Matched controls
1336
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
19.1
55.4
52
43
P29.30
ICD-10 Finland
Delayed closure of the ductus arteriosus
+∞
55.0
49
*
P07.3
ICD-10 Finland
Other preterm infants
17.0
44.0
42
35
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
+∞
38.3
35
*
P29.31
ICD-10 Finland
Persistent fetal circulation
+∞
34.9
32
*
P29.9
ICD-10 Finland
Cardiovascular disorder originating in the perinatal period, unspecified
+∞
33.7
31
*
P27.1
ICD-10 Finland
Bronchopulmonary dysplasia originating in the perinatal period
+∞
20.3
19
*
P07.2
ICD-10 Finland
Extreme immaturity
205.5
18.0
18
*
J45.1
ICD-10 Finland
Nonallergic asthma
5.3
16.5
42
106
WX722
NOMESCO Finland
PEEP
20.5
16.3
24
14
Z2221
NOMESCO Finland
Medical doctor
4.2
14.5
59
212
WX730
NOMESCO Finland
Conventional respirator
34.2
14.3
18
6
P29.1
ICD-10 Finland
Neonatal cardiac dysrhythmia
+∞
12.7
12
*
H35.1
ICD-10 Finland
Retinopathy of prematurity
+∞
12.7
12
*
P29.8
ICD-10 Finland
Other cardiovascular disorders originating in the perinatal period
+∞
12.7
12
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
3.9
11.3
42
139
602
Kela drug reimbursment
Children's severe malnutrition
5.2
11.0
25
56
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
4.8
10.8
28
70
FDE00
NOMESCO Finland
Closure of patent ductus arteriosus
+∞
10.5
10
*
ZXE10
NOMESCO Finland
More than one and less than three hours
3.3
10.4
59
255
Q25.0
ICD-10 Finland
Patent ductus arteriosus
11.4
10.4
19
19
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
5.8
9.6
19
37
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.2
9.3
55
241
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.2
8.8
26
72
R03AK06
ATC
salmeterol and fluticasone; inhalant
4.3
8.5
24
64
P07.01
ICD-10 Finland
Extremely low birth weight 500-749 g
+∞
8.4
8
*
WX882
NOMESCO Finland
High dependency care
3.4
8.2
35
125
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
7.7
60
300
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
4.3
7.7
22
59
XF400
NOMESCO Finland
ECG with 12 standard connections
2.9
7.4
44
190
P07.02
ICD-10 Finland
Extremely low birth weight 750-999 g
+∞
7.3
7
*
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
+∞
7.3
7
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.7
7.3
63
330
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
7.3
57
284
Z3229
NOMESCO Finland
Other healthcare associate professional
3.4
7.3
30
104
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
4.3
7.3
20
52
P07.10
ICD-10 Finland
Other low birth weight 1000-1499 g
31.8
7.2
9
*
FM2CE, ,
NOMESCO Finland
3.6
7.1
26
83
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.2
7.1
34
129
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.9
7.1
43
187
Z2446
NOMESCO Finland
Social worker
2.9
7.1
41
174
ZXD05
NOMESCO Finland
Urgent procedure
3.0
6.9
38
156
Z3226
NOMESCO Finland
Physiotherapist
2.7
6.9
51
246
R4110
NOMESCO Finland
Physiotherapy
2.7
6.9
54
269
RK312, ,
NOMESCO Finland
17.8
6.8
10
6
WX732
NOMESCO Finland
High frequency respirator
42.1
6.8
8
*
RK320, ,
NOMESCO Finland
42.1
6.8
8
*
ZX114
NOMESCO Finland
Intramuscular
8.5
6.8
14
18
ZXD20
NOMESCO Finland
Day surgery
4.1
6.7
20
55
Z3231
NOMESCO Finland
Registered nurse
2.6
6.7
70
400
P21.0
ICD-10 Finland
Severe birth asphyxia
+∞
6.3
6
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
46
242
2.36
4.95
6.6
4.4
1.09
1.12
inr
0.29
37
202
54
305
2.28
4.93
5.0
3.8
—
—
—
0
0
24
104
2.58
3.84
1.7
1.8
—
—
—
0
0
14
46
3.27
3.63
1.6
2.2
—
—
—
0
0
24
109
2.46
3.49
1.4
2.0
—
—
—
0
0
58
375
1.96
3.47
4.6
3.8
—
—
estimate
—
0
0
58
380
1.92
3.30
5.7
5.1
0.41
0.32
e6/l
0.11
43
268
32
170
2.15
3.24
4.5
6.7
1.13
2.44
mg/l
1.07
23
133
61
410
1.89
3.19
6.2
5.3
940.73
26.33
e6/l
0.48
46
301
45
278
1.92
3.01
5.1
4.5
2.41
2.25
e6/l
0.06
25
147
65
478
1.69
2.31
8.1
6.4
37.60
40.46
e6/l
0.04
46
311
22
118
2.03
2.16
2.1
2.6
21.55
8.83
iu/l
0.69
15
71
36
230
1.77
2.09
8.9
4.7
7.39
7.39
ph
0.11
26
154
6
15
4.12
2.05
2.0
2.4
—
—
—
0
0
8
26
3.20
2.04
13.9
5.9
7.39
7.38
ph
—
8
26
9
32
2.93
2.03
5.8
4.8
23.78
27.22
umol/l
—
9
32
7
21
3.45
1.99
2.7
3.0
—
—
—
0
0
22
122
1.95
1.97
2.0
2.6
9.63
5.24
u/l
0.51
12
66
5
11
4.66
1.95
21.6
2.7
1.10
1.06
mmol/l
—
5
11
6
16
3.86
1.95
1.2
1.1
—
—
—
0
0
31
195
1.76
1.89
3.8
4.4
—
—
—
0
0
20
111
1.94
1.79
1.2
2.7
—
—
—
0
0
46
327
1.61
1.78
14.7
13.0
—
—
—
0
0
8
30
2.76
1.75
13.9
6.9
—
—
—
0
0
31
441
0.61
1.60
1.6
2.1
—
—
—
0
0
49
364
1.54
1.54
2.0
1.5
—
—
—
0
0
7
27
2.67
1.53
3.0
4.0
17.36
17.80
mmol/l
—
7
27
76
621
1.51
1.52
13.5
11.0
5.97
6.03
mmol/l
0.09
76
586
14
73
2.02
1.49
1.7
1.9
18.79
19.14
ng/l
0.04
14
73
44
322
1.54
1.47
18.8
10.9
—
—
—
0
0
7
29
2.48
1.40
11.7
6.1
37.00
36.96
°c
—
7
29
34
237
1.58
1.40
6.3
3.8
454.90
592.83
mosm/kgh2o
2.44
29
207
63
503
1.47
1.37
5.4
3.9
0.00
0.00
estimate
-0.00
12
81
35
247
1.56
1.37
4.3
2.4
—
—
—
0
0
16
91
1.86
1.35
1.5
1.4
—
—
—
0
0
63
505
1.46
1.34
5.5
3.9
0.00
0.00
estimate
-0.00
12
76
63
505
1.46
1.34
5.5
4.0
0.00
0.00
estimate
-0.00
12
78
6
24
2.56
1.31
16.8
5.8
5.45
4.76
kpa
—
6
24
6
24
2.56
1.31
10.2
5.8
7.93
9.03
kpa
—
6
24
75
626
1.44
1.26
5.4
4.2
—
125.18
—
0
11
54
424
1.45
1.26
2.3
2.3
—
—
—
0
0
46
351
1.47
1.24
13.2
11.8
1.48
0.79
mmol/l
1.02
38
275
46
351
1.47
1.24
13.2
11.7
6.02
5.76
kpa
1.65
46
343
46
353
1.46
1.20
13.2
11.8
7.36
7.37
ph
0.24
34
235
59
475
1.43
1.19
4.5
8.6
—
—
—
0
0
27
185
1.57
1.19
2.3
1.8
—
—
—
0
0
5
20
2.55
1.15
1.2
1.1
—
—
—
0
0
8
41
2.00
1.10
2.4
1.5
—
—
—
0
0
5
21
2.43
1.09
24.6
8.0
7.86
5.29
pmol/l
—
5
21
46
360
1.42
1.07
21.0
11.2
7.40
7.41
ph
0.29
40
275
44
343
1.42
1.04
13.4
11.6
5.24
5.23
kpa
0.02
44
336
21
140
1.59
1.04
18.8
19.1
104.52
106.02
mmol/l
0.61
21
140
5
22
2.31
1.04
4.8
3.5
3.02
2.83
e9/l
—
5
22
10
53
1.95
1.03
1.5
2.0
—
—
—
0
0
10
53
1.95
1.03
1.5
2.0
—
—
—
0
0
10
53
1.95
1.03
1.5
2.0
—
—
—
0
0
10
53
1.95
1.03
1.5
2.0
—
—
—
0
0
55
448
1.38
1.01
3.4
3.7
6.48
6.36
ph
0.24
23
196
17
109
1.64
0.98
5.2
4.6
29.78
22.83
nmol/l
0.87
17
109
43
338
1.40
0.97
19.5
10.3
24.56
24.04
mmol/l
0.86
43
338
72
616
1.36
0.96
8.8
11.6
—
—
—
0
0
43
339
1.39
0.95
6.7
11.6
24.04
23.29
mmol/l
1.62
43
339
50
407
1.36
0.90
21.4
17.8
25.07
24.61
mmol/l
0.52
50
407
12
72
1.73
0.87
2.2
1.5
—
—
—
0
0
8
45
1.82
0.86
1.4
4.5
65.89
62.96
g/l
—
8
45
19
131
1.52
0.83
3.5
4.9
1168.08
1141.98
ng/l
0.01
12
90
16
106
1.57
0.82
2.8
2.0
227.17
143.24
u/ml
—
6
46
0
26
0.00
0.79
0.0
5.2
—
85.73
—
0
26
5
24
2.12
0.75
8.4
3.0
30.20
33.21
mmol/l
—
5
24
5
24
2.12
0.75
3.8
2.7
11.76
12.15
umol/l
—
5
24
44
362
1.32
0.72
16.6
10.0
36.98
37.63
g/l
0.26
44
349
14
201
0.66
0.72
1.3
1.5
—
110.63
—
0
8
107
997
1.35
0.66
26.8
16.7
138.94
139.34
mmol/l
0.84
107
976
107
997
1.35
0.66
26.4
16.6
3.99
3.97
mmol/l
0.21
107
966
20
147
1.42
0.65
22.5
23.0
1.41
1.35
mmol/l
0.12
20
141
0
20
0.00
0.61
0.0
1.3
—
0.85
—
0
20
49
563
0.79
0.61
1.7
1.9
1.56
1.43
g/l
0.34
23
277
51
583
0.79
0.60
1.9
2.2
1.07
3.85
u/ml
—
10
97
28
222
1.33
0.59
2.5
1.5
106.92
94.83
pmol/l
0.45
12
117
9
60
1.53
0.55
2.1
2.5
4.87
5.21
pmol/l
—
9
53
10
66
1.55
0.53
1.3
1.2
—
—
—
0
0
6
40
1.52
0.52
1.3
1.3
—
—
—
0
0
41
353
1.23
0.46
7.9
3.4
2.26
2.45
mg/l
0.34
36
315
18
140
1.33
0.44
1.3
2.3
—
—
—
0
0
8
56
1.45
0.43
2.0
26.4
78.49
73.54
%
—
8
56
8
56
1.45
0.43
2.1
26.6
68.85
73.90
%
—
8
56
5
31
1.63
0.43
1.0
1.2
—
—
—
0
0
22
177
1.29
0.43
2.4
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
0.65
—
0
7
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
25
206
1.26
0.41
6.1
7.4
1.31
1.36
%
0.22
25
199
57
513
1.19
0.40
6.2
4.0
36.00
36.94
mmol/mol
0.25
52
485
0
18
0.00
0.40
0.0
2.3
—
5.60
—
0
11
5
35
1.44
0.39
2.6
5.9
—
—
—
0
0
5
35
1.44
0.39
1.6
6.7
—
—
—
0
0
11
80
1.40
0.39
1.9
1.5
—
—
—
0
0
0
19
0.00
0.39
0.0
1.0
—
1.55
—
0
19
9
67
1.36
0.39
1.0
1.2
—
—
—
0
0
9
68
1.34
0.38
9.1
3.9
—
—
—
0
0
9
70
1.30
0.37
5.0
22.9
0.88
0.58
%
—
9
70
9
70
1.30
0.37
1.0
1.2
—
4.10
—
0
7
18
144
1.28
0.37
1.4
2.3
—
—
—
0
0
5
79
0.62
0.36
1.2
2.7
—
—
—
0
0
6
41
1.48
0.36
6.7
6.0
3.00
2.40
ug/l
—
6
41
18
146
1.26
0.33
1.4
2.3
—
—
—
0
0
18
146
1.26
0.33
1.4
2.3
—
—
—
0
0
6
46
1.31
0.33
2.0
6.4
—
—
—
0
0
14
174
0.78
0.32
1.8
2.1
—
—
—
0
0
18
147
1.26
0.32
1.4
2.3
—
—
—
0
0
14
173
0.78
0.31
2.0
2.2
—
—
—
0
0
10
75
1.36
0.30
1.8
1.8
—
—
—
0
0
18
149
1.24
0.29
1.7
1.7
—
—
—
0
0
8
65
1.24
0.27
3.8
2.2
48.44
48.69
%
—
8
65
10
125
0.78
0.24
1.7
2.9
—
—
—
0
0
15
124
1.23
0.24
1.3
2.2
—
—
—
0
0
5
37
1.36
0.24
1.4
2.9
—
—
—
0
0
127
1246
1.31
0.23
27.2
19.7
276.25
277.67
e9/l
0.08
122
1176
10
79
1.28
0.22
3.9
2.2
—
—
—
0
0
5
41
1.22
0.22
2.8
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
8.3
—
—
—
0
0
0
13
0.00
0.21
0.0
30.0
—
0.64
—
0
13
0
13
0.00
0.21
0.0
1.2
—
203.96
—
0
13
0
14
0.00
0.20
0.0
2.6
—
27.56
—
0
14
6
50
1.21
0.20
1.8
6.4
—
—
—
0
0
6
50
1.21
0.20
1.7
6.0
2.63
3.40
mmol/l
—
6
50
83
796
1.10
0.18
10.9
12.8
3.19
3.30
e9/l
0.20
73
630
9
79
1.15
0.15
1.6
2.0
8.82
9.85
nmol/l
—
9
71
10
118
0.83
0.15
3.2
2.5
29.20
22.01
ng/l
—
5
52
9
82
1.10
0.15
1.4
1.3
676.00
500.82
pmol/l
—
9
73
127
1249
1.26
0.15
27.0
19.6
7.10
7.11
e9/l
0.01
121
1173
127
1248
1.28
0.15
27.0
19.6
4.56
4.58
e12/l
0.17
121
1173
7
89
0.77
0.15
1.0
1.1
—
78.02
—
0
6
22
198
1.13
0.15
2.4
1.8
—
—
—
0
0
109
1064
1.11
0.14
15.8
8.6
—
—
—
0
0
25
272
0.90
0.14
1.1
1.4
—
—
—
0
0
77
741
1.08
0.14
11.6
12.7
0.00
0.00
e9/l
-0.00
63
526
27
250
1.10
0.11
3.2
3.1
1.01
1.02
kg/l
0.60
19
161
5
43
1.17
0.10
9.8
5.4
13.68
23.27
umol/l
—
5
35
87
847
1.07
0.10
3.5
3.5
14.37
14.42
pmol/l
0.08
78
776
5
44
1.14
0.10
1.0
1.3
—
—
—
0
0
114
1120
1.10
0.10
17.7
13.0
24.94
24.65
mg/l
0.03
82
793
6
53
1.13
0.09
1.8
5.9
1082.17
447.55
mg/l
—
6
53
5
61
0.81
0.08
1.2
1.0
—
—
—
0
0
8
75
1.07
0.07
33.5
21.9
90.68
96.00
%
—
8
75
21
196
1.08
0.07
1.8
1.8
—
—
—
0
0
80
783
1.05
0.06
10.3
11.8
0.20
0.22
e9/l
0.50
74
631
24
229
1.05
0.04
6.6
3.6
0.00
0.00
estimate
—
10
76
12
128
0.93
0.03
1.0
1.0
14.01
7.38
mu/l
1.00
12
119
10
92
1.09
0.03
27.1
18.6
7.37
7.37
ph
—
5
19
56
549
1.03
0.02
4.2
3.5
4.16
4.27
mmol/l
0.34
51
521
23
221
1.05
0.02
6.8
3.5
0.00
0.00
estimate
—
8
65
16
152
1.06
0.02
5.8
5.6
52.65
63.38
e9/l
0.94
11
92
22
226
0.96
0.01
12.1
5.9
—
—
—
0
0
27
263
1.03
0.01
2.3
2.3
—
—
—
0
0
78
784
0.98
0.00
10.7
10.8
2.54
2.58
e9/l
0.09
71
646
53
534
0.98
0.00
4.1
3.3
1.43
1.43
mmol/l
0.01
48
502
13
127
1.02
0.00
2.9
2.3
4.71
3.92
e9/l
0.58
13
118
19
194
0.97
0.00
4.5
2.8
289.00
350.67
nmol/l
0.69
19
186
32
315
1.02
0.00
5.8
3.3
0.00
0.00
estimate
—
9
69
77
769
1.00
0.00
10.5
10.8
0.04
0.04
e9/l
0.53
67
598
77
771
0.99
0.00
10.4
10.8
0.59
0.57
e9/l
0.30
67
600
10
101
0.99
0.00
2.1
2.6
26.40
31.18
u/l
—
10
76
60
595
1.01
0.00
2.2
2.4
5.36
5.33
mmol/l
0.05
54
535
53
533
0.99
0.00
4.2
3.4
2.61
2.53
mmol/l
0.32
48
504
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
8
0.00
0.00
0.0
8.9
—
0.58
—
0
8
0
6
0.00
-0.00
0.0
7.5
—
720.83
—
0
6
7
76
0.91
-0.00
37.4
21.6
0.84
0.96
%
—
7
76
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
84
0.95
-0.00
1.1
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
32.40
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
0.50
—
0
6
7
74
0.94
-0.00
37.4
22.1
0.59
0.70
%
—
7
74

Mortality – FinRegistry

↥

Association

Association between endpoint P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD and mortality.

Females

Parameter HR [95% CI] p-value
P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD 8.691 [4.36, 17.33] < 0.001
Birth year 0.993 [0.98, 1.0] 0.094

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 3415 females with P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD.

N-year risk Females Males
1 0.626% No data
5 4.213% No data
10 11.306% No data
15 21.689% No data
20 35.607% No data

Relationships between endpoints

↥

Index endpoint: P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD – Cardiovascular disorders originating in the perinatal period

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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