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Other respiratory conditions originating in the perinatal period

P16_OTH_RESPI_COND_ORIGINA_PERINA_PERIOD

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 P28
  • Cause of death: ICD-10 P28

2 out of 7 registries used, show all original rules.

56

4. Check minimum number of events

None

56

5. Include endpoints

None

56

6. Filter based on genotype QC (FinnGen only)

42

Control definitions (FinnGen only)

Control exclude
P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P2
Name in latin
Aliae condiciones respiratoriae origine perinatales

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3839 1774 2065
Only index persons 1696 755 941
Unadjusted period prevalence (%)
Whole population 0.05 0.05 0.06
Only index persons 0.03 0.03 0.04
Median age at first event (years)
Whole population - 0.01 0.01
Only index persons 0.00 0.00 0.00

-FinnGen-

Key figures

All Female Male
Number of individuals 42 27 15
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 0.05 0.01 0.11

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
53
Matched controls
506
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P28.4
ICD-10 Finland
Other apnoea of newborn
+∞
40.4
34
*
P07.3
ICD-10 Finland
Other preterm infants
15.0
9.6
16
14
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
13.2
7.6
13
12
WX722
NOMESCO Finland
PEEP
33.8
7.2
9
*
P01.5
ICD-10 Finland
Fetus and newborn affected by multiple pregnancy
44.0
6.8
8
*
602
Kela drug reimbursment
Children's severe malnutrition
11.9
6.8
12
12
J45.1
ICD-10 Finland
Nonallergic asthma
6.8
6.3
16
30
P27.1
ICD-10 Finland
Bronchopulmonary dysplasia originating in the perinatal period
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
6
13
4.82
2.25
4.5
4.5
22.17
21.31
umol/l
—
6
13
20
106
2.29
2.04
7.8
17.1
—
—
—
0
0
17
85
2.34
1.97
2.1
1.9
106.51
93.50
pmol/l
—
9
46
8
27
3.14
1.92
2.6
1.4
—
—
—
0
0
5
15
3.40
1.49
5.4
3.8
1.46
1.41
umol/l
—
5
15
7
27
2.69
1.48
1.9
2.4
—
—
—
0
0
7
27
2.69
1.48
1.9
2.4
—
—
—
0
0
7
27
2.69
1.48
1.9
2.4
—
—
—
0
0
7
27
2.69
1.48
1.9
2.4
—
—
—
0
0
19
112
1.97
1.42
6.4
18.6
7.36
7.37
ph
0.38
12
72
6
23
2.67
1.33
2.2
1.3
0.18
0.18
g/l
—
6
23
6
23
2.67
1.33
2.2
1.3
1.05
1.14
g/l
—
6
23
18
108
1.90
1.26
30.4
13.3
—
—
—
0
0
5
18
2.82
1.25
1.4
1.2
—
—
—
0
0
5
18
2.82
1.25
1.4
1.2
—
—
—
0
0
19
117
1.86
1.23
32.0
12.2
24.37
23.97
mmol/l
0.36
19
117
17
109
1.72
0.94
7.0
16.9
23.31
23.20
mmol/l
0.09
17
109
21
144
1.65
0.91
32.4
22.0
25.05
24.45
mmol/l
0.62
21
144
6
29
2.10
0.89
1.2
1.5
2.41
2.40
mmol/l
—
6
22
8
129
0.52
0.89
2.0
1.9
—
—
—
0
0
12
171
0.57
0.87
4.1
2.1
—
—
—
0
0
17
112
1.66
0.84
6.7
17.8
4.74
5.30
kpa
0.78
17
112
5
90
0.48
0.75
1.8
1.7
—
—
—
0
0
28
218
1.48
0.65
29.0
21.2
1.25
1.24
mmol/l
0.41
28
211
5
28
1.78
0.64
2.6
34.0
0.66
0.55
%
—
5
28
34
276
1.49
0.63
5.2
14.4
46.19
47.38
%
0.21
34
270
0
20
0.00
0.61
0.0
1.0
—
—
—
0
0
0
21
0.00
0.61
0.0
1.0
—
—
—
0
0
0
21
0.00
0.61
0.0
1.9
—
—
—
0
0
0
21
0.00
0.61
0.0
2.2
—
48.21
—
0
21
29
232
1.43
0.56
26.7
17.2
1.25
1.24
mmol/l
0.58
29
220
22
168
1.43
0.54
3.5
12.0
—
—
—
0
0
10
65
1.58
0.51
2.7
2.3
—
—
—
0
0
34
284
1.40
0.48
5.2
14.5
38.51
37.47
%
0.18
34
277
8
52
1.55
0.46
1.0
1.0
—
—
—
0
0
5
32
1.54
0.42
1.6
1.7
—
—
—
0
0
33
278
1.35
0.42
5.2
14.3
0.04
0.04
e9/l
0.16
27
217
0
14
0.00
0.42
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
9.8
—
—
—
0
0
34
288
1.35
0.41
5.1
14.2
2.65
2.56
e9/l
0.09
28
234
9
117
0.68
0.41
2.4
2.0
—
—
—
0
0
0
17
0.00
0.41
0.0
7.3
—
58.58
—
0
17
0
17
0.00
0.41
0.0
1.3
—
1104.91
—
0
11
14
103
1.40
0.41
1.6
2.9
2.39
2.39
mmol/l
0.02
14
94
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
32
270
1.33
0.39
5.3
15.0
0.57
0.60
%
0.10
32
261
32
271
1.32
0.37
5.3
14.9
2.75
3.05
%
0.41
32
262
13
97
1.37
0.34
1.3
1.3
—
—
—
0
0
6
44
1.34
0.34
1.3
1.6
—
502.86
—
0
7
10
123
0.72
0.32
9.6
2.5
—
—
—
0
0
33
284
1.29
0.32
5.6
16.9
0.00
0.00
e9/l
-0.00
24
204
11
81
1.37
0.31
1.3
1.9
—
—
—
0
0
34
295
1.28
0.30
5.9
17.2
3.62
3.45
e9/l
0.14
28
232
8
58
1.37
0.30
7.3
20.3
106.38
105.67
mmol/l
—
8
58
33
287
1.26
0.28
5.6
15.5
0.19
0.23
e9/l
0.73
27
236
32
278
1.25
0.27
5.3
14.3
0.61
0.57
e9/l
0.39
26
217
25
266
0.81
0.26
9.4
4.1
—
25.86
—
0
7
14
159
0.78
0.26
2.4
2.6
—
—
—
0
0
43
431
0.75
0.25
25.1
23.2
13.40
13.15
%
0.62
43
426
14
111
1.28
0.25
1.9
2.9
40.29
60.94
ug/g
0.89
14
82
5
35
1.40
0.24
1.2
1.1
—
—
—
0
0
25
214
1.22
0.23
6.0
17.8
—
—
—
0
0
22
186
1.22
0.23
13.6
6.3
13.96
36.93
e6/l
0.98
16
113
5
40
1.21
0.22
1.4
1.2
—
—
—
0
0
0
10
0.00
0.22
0.0
1.6
—
—
—
0
0
0
10
0.00
0.22
0.0
1.7
—
7.37
—
0
10
0
10
0.00
0.22
0.0
31.1
—
0.66
—
0
10
0
10
0.00
0.22
0.0
12.6
—
94.30
—
0
10
0
10
0.00
0.22
0.0
8.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
3.5
—
237.67
—
0
12
0
12
0.00
0.21
0.0
4.6
—
0.20
—
0
5
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
7
54
1.27
0.19
9.4
30.6
1.21
1.22
mmol/l
—
7
54
7
55
1.25
0.19
2.0
8.1
9.09
7.82
g/l
—
7
55
5
64
0.72
0.18
1.8
2.1
—
—
—
0
0
5
65
0.71
0.18
1.8
2.1
—
—
—
0
0
5
65
0.71
0.18
1.8
2.1
—
—
—
0
0
5
66
0.69
0.18
1.8
2.1
—
—
—
0
0
16
172
0.84
0.16
7.3
3.7
6.60
6.51
ph
—
5
73
20
172
1.18
0.16
1.4
1.9
—
—
—
0
0
7
84
0.76
0.16
1.4
1.7
—
—
—
0
0
12
99
1.20
0.14
2.3
2.9
1.02
1.02
kg/l
—
7
61
13
109
1.18
0.13
10.2
4.6
2.76
1.56
e6/l
—
7
55
26
265
0.88
0.12
7.0
4.7
—
—
—
0
0
17
147
1.15
0.12
11.3
5.1
0.10
0.17
e6/l
0.26
11
95
10
83
1.19
0.10
2.9
13.5
29.00
31.90
s
—
10
83
6
51
1.14
0.09
1.8
3.1
0.89
1.07
g/l
—
6
51
6
55
1.05
0.09
1.3
2.9
200.00
360.18
u/l
—
6
55
10
84
1.17
0.09
9.2
5.9
—
—
—
0
0
11
94
1.15
0.08
1.8
4.6
—
—
—
0
0
7
78
0.84
0.08
1.6
4.4
99.71
60.06
u/l
—
7
72
45
432
0.96
0.08
20.0
16.0
25.24
23.66
mg/l
0.11
34
328
45
421
1.14
0.07
10.8
10.9
—
—
—
0
0
10
85
1.15
0.07
1.7
1.7
—
—
—
0
0
15
153
0.91
0.05
6.6
15.5
71.27
33.87
umol/l
0.94
15
147
41
382
1.11
0.05
4.5
4.0
2.16
2.00
mu/l
0.50
41
362
21
210
0.93
0.04
2.3
2.0
1.14
1.41
g/l
0.89
15
114
16
145
1.08
0.03
12.1
5.1
—
—
estimate
—
0
0
42
407
0.93
0.01
8.3
13.3
50.38
53.85
umol/l
0.54
42
396
17
168
0.95
0.00
2.4
2.1
—
—
—
0
0
14
131
1.03
0.00
2.5
5.0
—
—
—
0
0
25
242
0.97
0.00
3.1
5.5
199.48
137.37
u/l
1.10
25
232
13
125
0.99
0.00
8.2
4.1
—
—
—
0
0
19
177
1.04
0.00
2.6
4.6
—
—
estimate
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
4.94
—
0
9
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
8.41
—
0
9
0
9
0.00
0.00
0.0
3.4
—
2.77
—
0
9
0
7
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
46
1.04
-0.00
2.8
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
24.37
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
5.40
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
2043.00
—
0
5
0
5
0.00
-0.00
0.0
2.0
—
0.44
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
0.16
—
0
5
5
48
0.99
-0.00
1.8
10.9
245.20
251.37
umol/l
—
5
48
0
6
0.00
-0.00
0.0
2.2
—
4.88
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
336.60
—
0
5
5
51
0.93
-0.00
3.8
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
1664.24
—
0
5
0
7
0.00
-0.00
0.0
2.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint P16_OTH_RESPI_COND_ORIGINA_PERINA_PERIOD and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_OTH_RESPI_COND_ORIGINA_PERINA_PERIOD.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: P16_OTH_RESPI_COND_ORIGINA_PERINA_PERIOD – Other respiratory conditions originating in the perinatal period

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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