Infections specific to the perinatal period

P16_INFECTIONS_SPECIFIC_PERINA_PERIOD

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 P35-P39
  • Cause of death: ICD-10 P35-P39

2 out of 7 registries used, show all original rules.

468

4. Check minimum number of events

None

468

5. Include endpoints

468

6. Filter based on genotype QC (FinnGen only)

415

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P
Name in latin
Infectiones temporis perinatalis specificae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 42413 17614 24798
Only index persons 19844 8095 11749
Unadjusted period prevalence (%)
Whole population 0.61 0.50 0.69
Only index persons 0.39 0.30 0.45
Median age at first event (years)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00

-FinnGen-

Key figures

All Female Male
Number of individuals 415 234 181
Unadjusted period prevalence (%) 0.08 0.08 0.08
Median age at first event (years) 0.00 0.00 0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
438
Matched controls
4378
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P39.9
ICD-10 Finland
Infection specific to the perinatal period, unspecified
+∞
177.5
158
*
P36.90
ICD-10 Finland
Suspected bacterial sepsis of newborn
+∞
165.4
148
*
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
5.0
30.2
72
165
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
7.5
28.5
43
63
P39.1
ICD-10 Finland
Neonatal conjunctivitis and dacryocystitis
+∞
26.3
25
*
P36.0
ICD-10 Finland
Sepsis of newborn due to streptococcus, group B
+∞
24.2
23
*
P36.99
ICD-10 Finland
Bacterial sepsis of newborn, unspecified
+∞
22.1
21
*
P07.3
ICD-10 Finland
Other preterm infants
4.2
21.4
62
165
P01.10
ICD-10 Finland
Fetus and newborn affected by premature rupture of membranes 1-7 days before delivery
18.4
20.3
31
18
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
11.5
13.2
24
22
P36.3
ICD-10 Finland
Sepsis of newborn due to other and unspecified staphylococci
+∞
12.6
12
*
P39.0
ICD-10 Finland
Neonatal infective mastitis
+∞
11.5
11
*
P39.4
ICD-10 Finland
Neonatal skin infection
+∞
11.5
11
*
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
3.0
8.2
36
125
P22.9
ICD-10 Finland
Respiratory distress of newborn, unspecified
6.3
7.9
20
33
WX722
NOMESCO Finland
PEEP
3.9
7.9
23
61
P02.7
ICD-10 Finland
Fetus and newborn affected by chorioamnionitis
45.8
7.7
9
*
P59.0
ICD-10 Finland
Neonatal jaundice associated with preterm delivery
3.8
7.6
23
63
ZX198
NOMESCO Finland
Other local administration
10.3
7.1
13
13
602
Kela drug reimbursment
Children's severe malnutrition
2.8
6.5
33
125
P38
ICD-10 Finland
Omphalitis of newborn with or without mild haemorrhage
70.8
6.4
7
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.1
6.4
27
92
P70.4
ICD-10 Finland
Other neonatal hypoglycaemia
3.1
6.3
26
87
P35.1
ICD-10 Finland
Congenital cytomegalovirus infection
+∞
6.3
6
*
P36.4
ICD-10 Finland
Sepsis of newborn due to Escherichia coli
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
92
575
1.76
5.12
5.1
4.3
—
—
—
0
0
6
9
6.74
2.87
1.0
1.0
—
—
—
0
0
140
1089
1.42
2.84
3.2
3.1
0.00
0.00
estimate
0.50
34
234
193
1598
1.37
2.67
4.0
3.7
0.00
5.72
estimate
0.50
40
284
190
1582
1.35
2.49
4.0
3.6
0.00
0.00
estimate
-0.00
41
290
7
16
4.43
2.48
1.1
1.3
—
—
—
0
0
8
21
3.86
2.47
1.1
1.1
—
—
—
0
0
192
1606
1.35
2.43
4.1
3.7
0.00
0.00
estimate
-0.00
42
282
23
121
1.95
2.25
4.0
4.8
7.72
10.71
e6/l
0.15
18
84
236
2055
1.32
2.19
10.7
12.0
0.00
0.01
e9/l
0.48
185
1574
9
30
3.04
2.15
1.0
1.1
—
—
—
0
0
95
724
1.40
2.12
4.9
4.5
7.39
7.38
ph
0.30
53
506
91
699
1.38
1.94
3.7
4.0
4.01
3.55
e6/l
0.10
43
359
37
237
1.61
1.91
2.6
3.6
—
—
—
0
0
162
1360
1.30
1.89
3.8
3.3
6.43
6.37
ph
0.27
79
647
378
3563
1.44
1.88
14.2
11.7
23.83
22.82
mg/l
0.24
276
2534
134
1098
1.32
1.86
4.3
4.4
0.24
0.21
e6/l
0.09
90
803
12
53
2.30
1.82
1.2
1.0
—
—
—
0
0
103
816
1.34
1.80
3.1
2.8
0.00
0.00
estimate
-0.00
36
232
36
233
1.59
1.80
6.6
5.6
0.69
0.34
%
0.54
13
77
95
747
1.35
1.74
3.3
3.6
0.00
0.00
estimate
-0.00
40
278
37
245
1.56
1.69
7.0
6.2
0.15
0.00
%
0.78
13
68
180
1550
1.27
1.69
15.5
13.6
1.23
1.23
mmol/l
0.12
172
1486
343
3200
1.33
1.67
17.2
13.2
3.92
3.90
mmol/l
0.35
337
3096
52
372
1.45
1.66
19.1
22.0
1.16
1.05
mg/l
0.82
52
367
10
41
2.47
1.65
1.2
3.1
—
—
—
0
0
37
249
1.53
1.58
6.6
6.2
0.92
0.55
%
0.37
12
84
72
554
1.36
1.52
4.1
4.9
4.36
1.40
mg/l
0.47
48
389
342
3205
1.30
1.50
17.2
13.2
139.45
139.51
mmol/l
0.27
336
3121
415
4015
1.63
1.49
21.4
17.4
275.25
270.12
e9/l
0.77
394
3855
140
1185
1.27
1.48
4.8
4.6
19.72
22.97
e6/l
0.14
97
892
74
575
1.34
1.47
1.7
1.5
18.19
18.52
nmol/l
0.09
64
513
7
28
2.52
1.45
1.0
1.0
—
—
—
0
0
7
28
2.52
1.45
1.0
1.0
—
—
—
0
0
415
4019
1.61
1.43
21.2
17.2
86.49
86.39
fl
0.15
408
3960
415
4020
1.61
1.42
21.3
17.3
4.62
4.64
e12/l
0.31
394
3850
415
4020
1.61
1.42
22.8
18.4
39.57
40.79
%
0.78
408
3962
415
4020
1.61
1.42
21.3
17.2
28.99
29.02
pg
0.14
408
3962
26
166
1.60
1.40
11.5
14.2
0.63
0.62
%
0.02
26
166
11
53
2.10
1.39
1.3
1.0
—
—
—
0
0
21
127
1.69
1.39
6.2
5.0
10.41
12.19
umol/l
0.18
16
109
415
4022
1.60
1.39
21.6
17.5
133.18
134.10
g/l
0.70
408
3967
9
41
2.22
1.37
1.4
1.6
480.78
315.72
pmol/l
—
9
36
42
300
1.44
1.37
1.6
1.4
—
—
—
0
0
415
4023
1.59
1.37
21.3
17.3
6.69
6.71
e9/l
0.06
394
3851
31
208
1.53
1.37
4.6
9.2
151.46
332.79
mg/l
2.95
26
163
5
17
2.96
1.36
1.0
1.1
—
—
—
0
0
5
17
2.96
1.36
2.2
20.8
—
—
—
0
0
22
136
1.65
1.35
3.3
3.9
—
—
—
0
0
0
39
0.00
1.34
0.0
1.2
—
32.17
—
0
10
0
39
0.00
1.34
0.0
1.2
—
18.09
—
0
11
363
3447
1.31
1.31
19.5
16.1
13.26
13.08
%
1.81
357
3396
19
115
1.68
1.26
4.6
4.9
—
—
—
0
0
98
811
1.27
1.24
5.3
5.5
—
—
—
0
0
187
1662
1.22
1.23
13.6
12.1
1.23
1.22
mmol/l
0.81
176
1532
35
247
1.45
1.23
1.0
1.1
—
—
—
0
0
121
1029
1.24
1.21
3.6
3.5
2.55
2.50
mg/l
0.11
111
916
18
109
1.68
1.20
4.7
7.5
25.03
24.16
mmol/l
0.49
18
103
162
1422
1.22
1.20
6.0
5.4
43.41
54.21
e6/l
0.21
99
931
97
805
1.26
1.20
6.1
5.8
1.13
1.17
inr
0.28
81
683
62
486
1.32
1.18
1.5
1.5
265.43
504.50
u/ml
0.67
57
456
8
39
2.07
1.15
6.6
8.8
—
—
—
0
0
34
242
1.44
1.15
6.9
6.2
0.00
0.04
%
—
10
75
0
35
0.00
1.15
0.0
1.2
—
—
—
0
0
372
3560
1.30
1.14
10.1
8.1
—
—
—
0
0
104
878
1.24
1.11
3.8
2.8
2.39
2.40
mmol/l
0.28
95
822
7
31
2.28
1.10
1.1
1.3
0.39
0.40
nmol/l
—
7
31
103
870
1.24
1.09
1.8
1.6
95.89
98.02
pmol/l
0.18
60
459
70
566
1.28
1.07
1.9
1.7
—
—
—
0
0
77
631
1.27
1.06
10.0
9.3
—
—
—
0
0
98
827
1.24
1.05
3.1
2.9
1.10
1.02
kg/l
0.50
57
505
253
2339
1.19
1.04
11.0
11.4
3.34
3.46
e9/l
0.47
210
1945
5
22
2.29
1.03
21.2
3.1
5.00
4.95
kpa
—
5
22
5
22
2.29
1.03
1.2
1.1
—
—
—
0
0
27
190
1.45
0.99
2.9
2.4
65.51
99.80
au/ml
0.74
11
76
19
124
1.56
0.98
2.4
1.6
—
—
—
0
0
45
347
1.33
0.98
2.3
2.4
6.44
5.49
u/l
0.55
32
214
0
30
0.00
0.97
0.0
4.7
—
207.71
—
0
17
7
36
1.96
0.97
2.1
2.4
—
—
—
0
0
11
62
1.79
0.95
1.2
1.2
—
—
—
0
0
239
2210
1.18
0.94
9.0
9.8
0.54
0.55
e9/l
0.15
201
1837
85
717
1.23
0.92
12.2
13.0
—
—
—
0
0
37
280
1.35
0.92
2.4
2.0
179.65
162.32
u/ml
0.15
20
123
6
28
2.16
0.92
2.2
2.2
32.33
31.68
pg
—
6
28
6
28
2.16
0.92
1.2
1.0
—
—
—
0
0
8
42
1.92
0.89
1.4
1.7
—
—
—
0
0
29
212
1.39
0.88
1.1
1.3
—
—
—
0
0
135
1196
1.19
0.88
8.1
8.1
18.50
18.64
umol/l
0.01
124
1106
18
120
1.52
0.86
4.6
4.6
3.54
3.32
mmol/l
0.55
18
115
95
817
1.21
0.86
3.1
2.4
—
—
—
0
0
15
96
1.58
0.85
5.5
5.7
—
—
—
0
0
8
138
0.57
0.84
1.1
1.1
—
6.33
—
0
23
86
734
1.21
0.84
12.0
9.3
7.40
7.41
ph
0.24
70
599
180
1639
1.17
0.84
9.8
10.3
—
—
—
0
0
216
1999
1.16
0.80
8.0
6.1
121.64
114.40
u/l
0.62
198
1892
168
1527
1.16
0.79
4.7
3.7
67.49
65.76
nmol/l
0.39
163
1446
107
1212
0.84
0.79
4.5
3.4
—
—
estimate
—
0
0
0
25
0.00
0.79
0.0
2.4
—
—
—
0
0
237
2212
1.15
0.78
9.1
9.8
0.04
0.04
e9/l
1.03
199
1841
17
115
1.50
0.78
2.6
2.2
—
—
—
0
0
17
115
1.50
0.78
2.6
2.2
—
—
—
0
0
17
115
1.50
0.78
2.2
4.5
190.55
160.60
e6/l
0.16
11
81
17
115
1.50
0.78
2.6
2.2
—
—
—
0
0
17
115
1.50
0.78
2.6
2.2
—
—
—
0
0
26
192
1.38
0.77
1.6
1.7
—
—
—
0
0
26
192
1.38
0.77
2.9
2.3
—
—
—
0
0
45
361
1.27
0.76
1.3
1.3
277.58
136.85
u/ml
—
9
107
0
28
0.00
0.76
0.0
1.2
—
—
—
0
0
9
53
1.71
0.76
8.2
3.3
1.36
1.43
%
—
9
48
231
2155
1.15
0.75
3.4
3.2
4.27
4.31
mmol/l
0.31
221
2063
233
2177
1.15
0.74
9.5
9.9
35.18
34.55
%
0.35
228
2093
7
38
1.85
0.74
1.3
1.1
—
—
—
0
0
10
159
0.62
0.73
1.3
1.2
—
—
—
0
0
228
2128
1.15
0.73
3.4
3.1
2.58
2.58
mmol/l
0.04
218
2019
41
328
1.28
0.72
4.1
4.3
54.69
70.66
mg/l
0.25
32
271
38
301
1.29
0.72
1.5
1.5
532.10
25094066.15
pmol/l
0.50
30
267
7
40
1.76
0.71
1.6
1.4
—
—
—
0
0
5
26
1.93
0.71
1.2
1.4
—
—
—
0
0
7
116
0.60
0.69
2.6
2.7
—
—
—
0
0
242
2276
1.14
0.68
9.8
10.4
0.19
0.21
e9/l
1.11
207
1940
12
78
1.55
0.66
1.5
1.5
—
—
—
0
0
240
2259
1.14
0.66
9.0
9.7
2.26
2.25
e9/l
0.05
207
1937
99
876
1.17
0.66
1.9
2.0
1.37
1.16
mmol/l
0.39
89
822
20
146
1.39
0.64
13.9
8.6
22.64
23.34
mmol/l
0.68
20
140
225
2112
1.13
0.64
3.3
3.0
1.36
1.42
mmol/l
1.63
215
2006
8
49
1.64
0.62
6.9
9.2
2.58
2.33
mg/l
—
8
40
9
138
0.64
0.61
1.1
1.4
—
—
—
0
0
64
740
0.84
0.61
1.5
1.7
—
—
—
0
0
293
2804
1.13
0.59
4.1
3.7
14.39
14.44
pmol/l
0.12
263
2500
83
732
1.16
0.58
3.1
3.5
500.31
600.55
mosm/kgh2o
3.14
74
649
89
790
1.16
0.57
11.8
10.6
7.37
7.37
ph
0.20
64
556
23
176
1.32
0.57
1.9
1.7
—
—
—
0
0
8
55
1.46
0.56
7.1
2.6
—
—
—
0
0
8
55
1.46
0.56
8.0
8.4
4.67
6.06
pmol/l
—
8
55
13
90
1.46
0.56
1.8
1.7
3.63
3.63
iu/l
—
7
40
6
37
1.63
0.55
2.0
2.2
—
—
—
0
0
24
186
1.31
0.55
1.7
1.6
1091.06
1123.89
nmol/l
0.06
18
141
8
124
0.64
0.55
1.0
1.2
—
—
—
0
0
17
125
1.37
0.54
1.1
1.5
0.70
3.32
u/ml
1.51
11
82
15
108
1.40
0.53
17.9
18.9
69.00
68.58
%
0.03
15
108
65
568
1.17
0.52
2.0
1.6
—
—
—
0
0
41
344
1.21
0.51
1.7
2.1
—
—
—
0
0
11
75
1.48
0.51
1.2
2.4
—
—
—
0
0
88
789
1.14
0.50
10.7
10.6
0.14
1.14
mmol/l
1.07
72
638
12
84
1.44
0.49
3.3
4.7
82.55
5.34
u/ml
0.48
12
84
7
45
1.56
0.49
2.7
2.7
—
—
—
0
0
24
190
1.28
0.49
1.3
1.7
0.20
0.19
mg/l
—
5
75
216
2046
1.11
0.49
4.5
3.8
55.34
46.85
ug/l
0.37
208
1961
13
93
1.41
0.48
1.4
2.0
—
—
—
0
0
11
76
1.46
0.48
3.0
5.0
—
—
—
0
0
88
792
1.14
0.48
2.1
1.7
—
—
—
0
0
158
1687
0.90
0.47
1.7
1.9
0.78
3.06
u/ml
3.06
25
332
204
1930
1.11
0.47
3.3
2.8
1.10
1.06
mmol/l
0.35
197
1830
18
231
0.77
0.46
1.2
1.1
1.06
1.29
u/ml
—
8
113
221
2101
1.10
0.46
9.7
10.0
2.84
3.19
%
1.51
216
2000
11
77
1.44
0.46
1.5
1.4
—
—
—
0
0
167
1567
1.11
0.45
2.5
2.3
—
—
—
0
0
344
3349
1.12
0.44
10.5
9.5
25.77
24.01
u/l
0.87
334
3250
6
95
0.63
0.42
1.0
1.0
—
—
—
0
0
6
95
0.63
0.42
1.0
1.0
18.50
19.17
mmol/l
—
6
95
221
2108
1.10
0.42
9.8
10.0
8.43
8.45
%
0.05
216
2003
38
324
1.19
0.42
5.5
4.8
5.96
6.69
mg/mmol
0.08
30
267
5
33
1.52
0.41
2.4
2.4
342.20
1128.06
u/ml
—
5
33
0
15
0.00
0.41
0.0
4.7
—
4.56
—
0
15
0
15
0.00
0.41
0.0
2.6
—
3.78
—
0
15
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
6.4
—
44.28
—
0
16
15
114
1.33
0.41
2.1
4.5
583.11
531.00
e6/l
—
9
80
19
150
1.28
0.40
1.1
1.2
—
—
—
0
0
5
34
1.48
0.40
1.2
1.1
—
—
—
0
0
81
735
1.12
0.40
10.6
10.3
22.98
23.63
mmol/l
1.20
81
735
236
2262
1.09
0.39
2.8
2.5
5.52
5.34
mmol/l
0.70
215
2072
14
106
1.33
0.39
1.1
1.3
199.83
314.36
iu/ml
—
6
28
0
19
0.00
0.39
0.0
1.2
—
197.98
—
0
19
0
19
0.00
0.39
0.0
1.1
—
1352.11
—
0
19
19
151
1.27
0.39
1.1
1.2
—
—
—
0
0
50
440
1.15
0.38
2.8
2.4
14432.04
8559.66
u/l
—
10
128
10
136
0.73
0.38
1.2
1.2
—
—
—
0
0
11
81
1.37
0.36
2.9
5.9
—
—
—
0
0
9
71
1.27
0.36
1.0
1.1
—
—
—
0
0
20
162
1.25
0.36
20.0
20.1
93.85
95.66
%
0.30
20
162
6
44
1.37
0.34
3.8
3.1
53.67
59.14
umol/l
—
6
44
15
118
1.28
0.34
2.1
4.6
1332.56
1413.00
e6/l
—
9
84
48
427
1.14
0.33
6.7
7.4
5.25
6.38
umol/l
0.55
40
357
32
369
0.86
0.33
1.3
1.2
2.30
2.51
u/ml
0.07
24
265
10
74
1.36
0.32
5.0
4.4
—
—
—
0
0
6
47
1.28
0.32
1.2
1.1
—
—
—
0
0
107
1141
0.92
0.31
1.9
1.5
—
—
—
0
0
41
364
1.14
0.29
6.0
5.6
61.76
63.28
e9/l
0.10
30
220
139
1319
1.08
0.28
6.6
8.6
—
—
—
0
0
16
193
0.82
0.27
1.2
1.1
—
—
—
0
0
89
832
1.09
0.26
2.7
3.5
60.45
102.23
ug/g
2.11
73
670
39
349
1.13
0.26
17.8
15.1
105.59
105.38
mmol/l
0.11
39
349
31
350
0.88
0.25
2.2
2.0
—
—
—
0
0
14
114
1.24
0.25
2.1
4.8
0.22
0.35
e9/l
—
8
74
9
75
1.20
0.25
28.2
23.5
10.51
11.52
%
—
9
75
9
75
1.20
0.25
3.2
7.2
7.39
7.39
ph
—
9
75
19
161
1.19
0.24
20.7
20.2
0.65
0.69
%
0.27
19
161
87
817
1.08
0.23
18.8
15.9
24.68
24.73
mmol/l
0.05
87
817
57
525
1.10
0.23
3.3
2.4
21.41
24.88
ng/l
0.14
17
190
83
779
1.08
0.23
4.3
3.5
7.00
7.92
e6/l
0.27
74
702
21
242
0.86
0.23
1.1
1.1
26.49
11.97
u/ml
0.31
12
155
5
39
1.28
0.23
3.8
2.1
—
—
—
0
0
5
39
1.28
0.23
2.2
4.4
48.52
23.55
ug/l
—
5
39
316
3100
1.07
0.23
4.7
4.2
1.92
1.96
mu/l
0.23
300
2946
5
40
1.25
0.22
10.8
3.1
1.07
1.23
mmol/l
—
5
32
5
40
1.25
0.22
1.8
1.3
97.20
126.10
pmol/l
—
5
40
47
430
1.10
0.22
1.5
2.1
—
—
—
0
0
60
557
1.09
0.21
8.7
6.6
31.88
30.72
s
0.64
60
550
0
10
0.00
0.21
0.0
1.4
—
57.80
—
0
10
0
10
0.00
0.21
0.0
2.9
—
277.20
—
0
10
0
10
0.00
0.21
0.0
1.2
—
26.80
—
0
10
8
102
0.78
0.21
1.3
1.2
—
—
—
0
0
185
1790
1.06
0.21
10.9
7.9
6.29
6.05
mmol/l
0.55
176
1679
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
37
336
1.11
0.20
2.1
2.4
4.45
7.43
iu/l
3.08
26
216
0
14
0.00
0.20
0.0
2.2
—
180.64
—
0
14
0
14
0.00
0.20
0.0
2.7
—
106.57
—
0
14
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
2.7
—
1.22
—
0
14
53
492
1.09
0.19
2.6
2.4
—
—
—
0
0
6
51
1.18
0.19
7.0
4.8
1.00
0.49
index
—
6
51
18
206
0.87
0.18
1.0
1.1
—
—
—
0
0
13
153
0.84
0.18
8.4
5.8
123.31
175.89
ng/l
0.42
13
142
45
416
1.09
0.18
5.5
3.3
1246.45
1261.29
ng/l
0.01
20
224
7
58
1.21
0.18
3.4
8.0
7.96
9.16
kpa
—
7
58
7
58
1.21
0.18
3.3
8.0
5.70
4.85
kpa
—
7
58
13
110
1.19
0.17
2.2
4.8
42.60
37.10
%
1.20
13
110
19
168
1.14
0.16
1.5
1.5
0.21
0.20
g/l
0.16
19
162
19
169
1.13
0.14
1.4
1.5
1.17
1.13
g/l
0.41
19
162
7
87
0.80
0.14
1.4
1.1
—
—
—
0
0
15
131
1.15
0.14
1.3
1.3
—
—
—
0
0
38
408
0.92
0.14
1.3
1.3
3.25
3.22
u/ml
0.00
26
287
203
1985
1.04
0.14
4.5
3.4
36.15
35.57
mmol/mol
0.32
194
1885
35
377
0.92
0.14
1.2
1.2
0.46
1.39
u/ml
1.65
25
264
33
305
1.09
0.14
1.7
2.2
10.80
8.94
nmol/l
0.31
27
272
9
109
0.82
0.13
1.0
1.0
1.44
1.53
g/l
—
9
109
24
219
1.10
0.13
18.8
15.7
7.38
7.40
ph
—
8
76
14
123
1.14
0.12
1.4
1.5
16.21
17.94
u/ml
—
9
76
183
1792
1.04
0.11
3.9
4.5
27.58
25.98
u/l
0.27
169
1722
36
383
0.93
0.11
1.2
1.2
7.65
7.31
u/ml
0.04
27
285
48
505
0.94
0.11
1.5
1.6
920.00
455.47
titre
—
6
75
10
86
1.17
0.11
1.3
1.5
—
—
—
0
0
19
208
0.91
0.10
2.4
1.9
6.00
6.34
ph
0.93
12
126
13
115
1.13
0.10
3.7
2.1
1.02
1.02
ratio
0.16
13
96
82
792
1.04
0.10
2.5
1.9
—
—
—
0
0
11
96
1.15
0.10
7.5
3.3
590.82
404.53
ug/l
0.44
11
88
42
399
1.06
0.09
1.3
1.2
1.83
9.21
u/ml
1.27
16
120
5
48
1.04
0.09
1.0
1.2
—
400.09
—
0
11
5
48
1.04
0.09
4.6
3.2
20.60
49.62
u/ml
—
5
40
24
257
0.93
0.09
1.2
1.1
10.27
6.74
u/ml
0.35
17
168
6
56
1.07
0.08
1.0
1.1
—
—
—
0
0
24
224
1.08
0.08
1.2
1.4
2.89
2.96
mmol/l
0.13
12
132
5
62
0.80
0.08
1.0
1.7
7.57
13.83
u/ml
—
5
50
6
75
0.80
0.07
1.0
1.4
—
184.00
—
0
15
60
580
1.04
0.07
1.4
1.7
—
—
—
0
0
8
78
1.03
0.07
7.6
5.7
2.52
2.04
ug/l
—
8
78
60
619
0.96
0.07
1.5
1.7
—
—
—
0
0
50
482
1.04
0.07
2.3
1.8
—
—
—
0
0
8
90
0.89
0.07
1.5
2.1
216.38
136.77
ng/l
—
8
85
12
109
1.10
0.06
1.8
1.0
0.94
0.80
g/l
0.38
12
109
60
617
0.97
0.06
1.5
1.7
—
—
—
0
0
34
326
1.05
0.05
2.9
1.8
2.43
2.41
mmol/l
0.52
28
276
46
446
1.03
0.05
1.3
1.2
8.83
15.71
iu/ml
—
6
91
76
774
0.98
0.04
2.3
2.0
—
—
—
0
0
19
200
0.95
0.04
1.5
1.3
275.62
216.07
miu/ml
—
8
97
158
1565
1.01
0.03
1.7
1.8
1.48
1.55
g/l
0.31
86
849
19
181
1.05
0.03
1.5
1.3
—
—
—
0
0
49
500
0.98
0.02
1.5
1.7
—
—
—
0
0
61
620
0.98
0.02
1.5
1.7
—
—
—
0
0
17
178
0.95
0.02
2.9
2.8
49.35
54.13
%
0.73
17
178
34
331
1.03
0.02
1.9
1.5
—
—
—
0
0
10
93
1.08
0.02
1.2
1.4
346.00
368.53
ug/g
—
5
49
70
708
0.99
0.01
1.3
1.3
—
—
—
0
0
29
283
1.03
0.01
1.6
1.5
—
—
—
0
0
49
496
0.99
0.00
1.1
1.3
—
3.30
—
0
5
88
886
0.99
0.00
4.6
3.5
—
—
—
0
0
24
244
0.98
0.00
1.3
1.3
—
—
—
0
0
27
271
1.00
0.00
1.4
2.1
—
—
—
0
0
36
357
1.01
0.00
3.7
1.9
—
—
—
0
0
20
198
1.01
0.00
1.3
1.1
—
—
—
0
0
119
1184
1.01
0.00
2.6
2.3
—
—
—
0
0
62
620
1.00
0.00
1.5
1.7
—
—
—
0
0
32
317
1.01
0.00
3.8
2.4
27.59
31.20
u/l
0.71
27
257
0
7
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
5.1
—
138.33
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
70.40
—
0
5
0
6
0.00
-0.00
0.0
22.0
—
13.62
—
0
6
0
5
0.00
-0.00
0.0
3.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
9.34
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
7
70
1.00
-0.00
1.9
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.8
—
13.17
—
0
6
8
79
1.01
-0.00
2.0
3.6
0.72
0.78
e9/l
—
8
79
0
6
0.00
-0.00
0.0
1.5
—
75.10
—
0
6
8
89
0.90
-0.00
2.1
1.4
—
—
—
0
0
7
79
0.88
-0.00
1.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
305.00
—
0
5
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
6
60
1.00
-0.00
4.8
2.3
51.33
35.87
mmol/l
—
6
60
0
5
0.00
-0.00
0.0
4.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
0.00
—
0
6
0
6
0.00
-0.00
0.0
1.3
—
6.35
—
0
6
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.8
—
29.00
—
0
6
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
9
89
1.01
-0.00
1.1
1.8
0.74
5.18
u/ml
—
9
89
8
82
0.97
-0.00
4.1
4.0
2.61
3.30
e9/l
—
8
82
0
5
0.00
-0.00
0.0
9.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
215.80
—
0
5

Mortality – FinRegistry

Association

Association between endpoint P16_INFECTIONS_SPECIFIC_PERINA_PERIOD and mortality.

Females

Parameter HR [95% CI] p-value
P16_INFECTIONS_SPECIFIC_PERINA_PERIOD 1.84 [1.45, 2.34] < 0.001
Birth year 0.998 [0.99, 1.01] 0.613

During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 16734 females with P16_INFECTIONS_SPECIFIC_PERINA_PERIOD died.

Males

Parameter HR [95% CI] p-value
P16_INFECTIONS_SPECIFIC_PERINA_PERIOD 1.099 [0.9, 1.34] 0.351
Birth year 0.987 [0.98, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 113 out of 23642 males with P16_INFECTIONS_SPECIFIC_PERINA_PERIOD died.

Mortality risk

Mortality risk for people of age

years, who have P16_INFECTIONS_SPECIFIC_PERINA_PERIOD.

N-year risk Females Males
1 0.158% 0.199%
5 1.081% 1.32%
10 2.695% 3.159%
15 5.399% 6.062%
20 9.582% 10.507%

Relationships between endpoints

Index endpoint: P16_INFECTIONS_SPECIFIC_PERINA_PERIOD – Infections specific to the perinatal period

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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