bacteriemia: An infectious disease caused by bacteria causing sepsis.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
232 |
4. Check minimum number of eventsNone |
232 |
5. Include endpointsNone |
232 |
6. Filter based on genotype QC (FinnGen only) |
204 |
Control definitions (FinnGen only)
- Control exclude
- P16_INFECTIONS_SPECIFIC_PERINA_PERIOD
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- P3
- Name in latin
- Sepsis bacterialis neonatorum
Similar endpoints
↥List of similar endpoints to
Bacterial sepsis of newborn
based on the number of shared cases.
Similar with more cases:
- Infections specific to the perinatal period
- Certain conditions originating in the perinatal period
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 26986 | 11234 | 15752 |
| Only index persons | 10206 | 4214 | 5992 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.39 | 0.32 | 0.44 |
| Only index persons | 0.20 | 0.15 | 0.23 |
| Median age at first event (years) | |||
| Whole population | - | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 204 | 117 | 87 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | 0.00 | 0.00 | 0.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 215
- Matched controls
- 2148
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P36.90
ICD-10 Finland
Suspected bacterial sepsis of newborn
+∞
183.6
149
*
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
7.3
29.9
51
88
P36.0
ICD-10 Finland
Sepsis of newborn due to streptococcus, group B
+∞
24.4
23
*
P36.99
ICD-10 Finland
Bacterial sepsis of newborn, unspecified
+∞
22.3
21
*
P07.3
ICD-10 Finland
Other preterm infants
5.8
19.1
39
79
P36.3
ICD-10 Finland
Sepsis of newborn due to other and unspecified staphylococci
+∞
12.6
12
*
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
15.6
12.5
20
14
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
5.9
10.6
20
37
P39.9
ICD-10 Finland
Infection specific to the perinatal period, unspecified
+∞
7.3
7
*
P01.10
ICD-10 Finland
Fetus and newborn affected by premature rupture of membranes 1-7 days before delivery
11.5
6.9
12
11
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
3.2
6.6
27
91
602
Kela drug reimbursment
Children's severe malnutrition
3.6
6.6
23
70
P36.4
ICD-10 Finland
Sepsis of newborn due to Escherichia coli
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
27
150
1.91
2.33
6.0
7.9
288.11
328.30
u/l
0.43
27
145
74
547
1.54
2.24
4.4
3.7
2.60
2.38
mg/l
0.51
67
486
57
399
1.58
2.19
4.4
4.6
4.32
2.61
e6/l
0.28
27
215
7
19
3.77
2.16
1.1
1.3
—
—
—
0
0
6
15
4.08
2.05
1.2
1.2
—
—
—
0
0
5
13
3.91
1.72
1.2
1.1
64.40
349.46
u/l
—
5
13
55
402
1.49
1.71
4.7
4.4
0.80
0.72
e6/l
0.07
25
216
53
390
1.47
1.59
4.6
3.8
—
—
—
0
0
20
118
1.76
1.47
3.0
2.3
59.07
94.34
au/ml
—
9
52
9
43
2.14
1.32
1.1
1.2
—
—
—
0
0
97
817
1.34
1.30
4.7
4.0
0.00
0.00
estimate
-0.00
13
137
12
62
1.99
1.30
2.7
2.0
—
60.67
—
0
6
5
18
2.82
1.29
1.4
1.9
2.52
3.61
mg/l
—
5
11
5
18
2.82
1.29
1.4
1.9
2.73
7.63
mg/l
—
5
13
31
214
1.52
1.27
2.7
2.4
—
—
—
0
0
17
101
1.74
1.23
7.0
14.8
0.62
0.60
%
0.07
17
101
13
71
1.88
1.22
3.1
4.9
—
—
—
0
0
97
824
1.32
1.20
4.6
4.0
0.00
0.00
estimate
-0.00
14
137
31
218
1.49
1.17
2.5
2.3
—
—
—
0
0
74
607
1.33
1.16
9.0
9.8
23.64
24.29
umol/l
0.04
68
564
5
20
2.53
1.15
1.0
1.1
—
—
—
0
0
5
20
2.53
1.15
1.0
2.1
—
—
—
0
0
16
96
1.72
1.13
2.4
2.3
—
—
—
0
0
7
30
2.37
1.13
6.1
8.6
2.22
1.63
mg/l
—
7
25
95
811
1.31
1.12
4.7
4.0
0.00
0.00
estimate
-0.00
13
143
54
426
1.36
1.09
3.4
3.2
1.02
1.02
kg/l
0.04
34
267
35
257
1.43
1.07
2.8
2.3
—
—
—
0
0
72
595
1.31
1.07
5.5
5.0
0.18
0.29
e6/l
0.53
50
430
12
67
1.84
1.06
4.7
6.8
496.83
442.13
mg/l
0.13
12
67
5
22
2.30
1.04
11.8
7.5
—
—
—
0
0
38
287
1.39
1.00
4.9
6.1
7.52
1.90
mg/l
0.49
26
210
10
173
0.56
1.00
1.2
1.2
—
6.04
—
0
5
65
534
1.31
1.00
3.3
3.4
0.00
0.00
estimate
—
10
114
18
116
1.60
1.00
1.7
1.7
—
—
—
0
0
16
100
1.65
0.99
1.9
2.0
—
—
—
0
0
57
462
1.32
0.96
3.3
2.9
2.40
2.40
mmol/l
0.01
51
431
11
62
1.81
0.96
4.2
2.0
1.02
1.02
ratio
0.21
11
51
11
63
1.78
0.91
1.7
2.4
—
—
—
0
0
10
168
0.57
0.91
1.6
1.5
—
—
—
0
0
58
476
1.30
0.89
10.3
11.6
-0.37
1.02
mmol/l
1.11
46
378
10
167
0.58
0.89
1.4
1.3
—
—
—
0
0
38
295
1.35
0.86
1.6
1.5
20.13
19.14
nmol/l
0.22
33
258
112
1000
1.25
0.86
8.2
6.2
136.65
129.56
u/l
0.33
103
952
77
663
1.25
0.80
5.7
5.3
—
—
—
0
0
6
33
1.84
0.79
1.0
1.0
—
—
—
0
0
6
33
1.84
0.79
4.5
6.5
—
—
—
0
0
56
466
1.27
0.78
15.0
10.7
1.15
0.84
mmol/l
0.47
45
337
93
821
1.23
0.77
4.8
5.6
30.15
25.38
u/l
0.69
88
791
15
218
0.66
0.77
1.3
1.2
—
15.77
—
0
42
134
1232
1.23
0.74
11.9
12.7
3.12
3.35
e9/l
0.72
109
1013
5
25
2.02
0.73
2.4
1.9
—
—
—
0
0
5
26
1.94
0.71
10.4
7.0
—
—
—
0
0
11
69
1.62
0.69
1.4
2.3
—
—
—
0
0
10
61
1.67
0.69
3.2
6.3
96.10
97.95
%
—
10
61
51
426
1.26
0.69
1.9
1.5
90.54
95.44
pmol/l
0.34
33
215
150
1402
1.23
0.67
3.9
3.7
14.31
14.44
pmol/l
0.27
140
1267
15
103
1.49
0.66
2.6
2.4
—
—
—
0
0
205
1995
1.57
0.65
26.7
19.5
282.09
273.37
e9/l
0.94
198
1908
5
29
1.74
0.64
2.4
1.3
—
—
—
0
0
5
29
1.74
0.64
8.2
5.2
1.00
0.62
index
—
5
29
205
1997
1.55
0.62
26.6
19.4
4.60
4.60
e12/l
0.10
197
1902
15
206
0.71
0.59
1.3
1.2
2.98
10.10
u/ml
—
6
58
23
176
1.34
0.59
1.3
1.4
286.68
137.63
u/ml
—
5
55
90
988
0.85
0.56
2.0
2.2
—
—
—
0
0
9
59
1.55
0.55
1.3
3.1
—
—
—
0
0
6
96
0.61
0.53
1.0
1.3
—
—
—
0
0
87
950
0.86
0.49
14.3
8.3
110.32
110.80
ml/min/173m2
0.05
66
686
25
200
1.28
0.49
12.7
14.6
105.52
105.42
mmol/l
0.04
25
200
7
47
1.50
0.48
2.1
4.2
0.71
0.73
e9/l
—
7
47
10
68
1.49
0.47
2.5
5.3
26.40
26.82
%
—
10
68
21
165
1.30
0.47
2.9
2.0
139.82
165.25
u/ml
0.17
11
74
11
77
1.45
0.46
1.6
1.2
—
—
—
0
0
7
50
1.41
0.45
2.4
1.8
—
—
—
0
0
12
86
1.42
0.45
4.0
2.5
—
—
—
0
0
9
129
0.68
0.44
1.2
1.1
—
40.23
—
0
13
13
95
1.39
0.44
13.5
18.3
91.88
95.76
%
0.46
13
95
17
217
0.76
0.44
1.2
1.2
2.34
2.51
u/ml
0.03
11
163
5
31
1.63
0.43
3.0
1.5
—
—
—
0
0
8
56
1.44
0.43
1.4
1.9
—
—
—
0
0
5
32
1.57
0.42
3.0
1.9
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
336.13
—
0
15
0
17
0.00
0.41
0.0
2.3
—
—
—
0
0
7
102
0.68
0.40
1.9
2.1
—
—
—
0
0
5
34
1.48
0.40
1.0
1.1
—
—
—
0
0
5
36
1.40
0.38
3.4
4.5
474.40
423.22
umol/l
—
5
36
51
453
1.16
0.38
10.1
11.1
22.84
23.48
mmol/l
0.86
51
453
10
72
1.41
0.37
2.5
5.3
10.20
8.51
%
—
10
72
66
601
1.14
0.35
5.2
3.8
—
—
estimate
—
0
0
14
176
0.78
0.33
1.9
2.7
4.16
6.80
iu/l
—
8
107
10
74
1.37
0.33
1.4
2.3
—
—
—
0
0
11
83
1.34
0.32
1.3
1.5
—
—
—
0
0
11
83
1.34
0.32
1.3
1.5
—
—
—
0
0
184
1794
1.17
0.31
3.9
3.9
—
—
—
0
0
11
84
1.32
0.30
1.8
1.3
254.19
220.42
miu/ml
—
5
35
8
109
0.72
0.29
1.4
2.0
—
—
—
0
0
12
94
1.29
0.28
14.2
18.4
0.78
0.65
%
1.24
12
94
10
76
1.33
0.28
1.0
1.3
—
—
—
0
0
9
73
1.24
0.26
2.4
1.5
—
—
—
0
0
9
73
1.24
0.26
2.6
5.3
—
—
—
0
0
43
391
1.12
0.24
2.9
3.1
0.00
0.00
estimate
-0.00
11
114
5
37
1.36
0.23
1.0
1.9
—
—
—
0
0
5
38
1.32
0.23
1.0
1.6
105.00
76.16
%
—
5
38
183
1792
1.14
0.23
17.1
13.1
25.43
24.15
mg/l
0.21
139
1282
54
499
1.11
0.23
2.9
2.7
—
—
—
0
0
5
41
1.22
0.22
2.4
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
22.58
—
0
10
0
11
0.00
0.21
0.0
2.5
—
22.91
—
0
11
0
12
0.00
0.21
0.0
1.1
—
16.06
—
0
12
6
51
1.18
0.19
1.0
1.5
—
—
—
0
0
56
525
1.09
0.18
18.9
16.3
24.34
24.67
mmol/l
0.39
56
525
7
59
1.19
0.18
2.1
1.5
—
—
—
0
0
22
196
1.14
0.17
2.6
2.6
22067.63
5287.67
u/l
—
6
51
51
478
1.09
0.16
2.7
2.5
—
—
—
0
0
32
293
1.11
0.16
1.1
1.1
—
—
—
0
0
24
216
1.12
0.16
6.7
3.6
647.64
960.47
ng/l
0.36
11
125
6
78
0.76
0.16
2.2
1.5
—
—
—
0
0
178
1750
1.09
0.15
25.0
18.4
13.39
13.13
%
1.46
178
1731
21
231
0.90
0.13
1.2
1.3
2.65
3.83
u/ml
0.28
15
173
12
105
1.15
0.11
1.8
2.0
14.81
18.60
ng/l
1.14
12
105
5
47
1.06
0.09
3.2
4.6
187.20
6.27
u/ml
—
5
47
6
54
1.11
0.09
7.3
5.9
2.25
1.98
ug/l
—
6
54
6
54
1.11
0.09
4.3
3.1
17.08
8.73
ug/l
—
6
42
6
55
1.09
0.09
1.3
1.5
40.35
58.15
ug/l
—
6
55
5
61
0.81
0.08
1.4
1.1
—
7.77
—
0
10
39
372
1.06
0.08
2.3
2.5
—
—
—
0
0
96
939
1.04
0.07
12.9
9.0
6.57
6.10
mmol/l
0.84
89
888
107
1049
1.04
0.07
5.3
4.2
—
122.00
—
0
18
15
138
1.09
0.06
2.1
1.6
—
—
—
0
0
11
121
0.90
0.06
1.4
1.4
—
—
—
0
0
116
1144
1.03
0.04
4.6
5.2
8.94
7.15
mm/h
0.70
110
1080
20
189
1.06
0.04
2.4
2.7
5.51
5.42
u/l
0.03
13
113
21
219
0.95
0.03
1.1
1.3
9.98
7.22
u/ml
0.20
15
169
35
340
1.03
0.03
2.2
2.3
—
—
—
0
0
25
241
1.04
0.02
4.6
2.6
34.71
36.70
ng/l
—
7
95
21
218
0.96
0.02
1.1
1.3
0.40
1.03
u/ml
1.09
14
163
18
172
1.05
0.02
1.7
1.2
—
—
—
0
0
37
378
0.97
0.02
3.1
4.0
0.00
0.00
estimate
-0.00
14
137
92
911
1.02
0.01
1.8
2.1
1.17
3.47
u/ml
1.46
14
169
16
166
0.96
0.01
5.3
2.7
29.27
33.02
u/l
0.34
11
126
6
67
0.89
0.00
2.3
2.4
0.21
0.12
nmol/l
—
6
58
9
98
0.91
0.00
2.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
26.1
—
26.00
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
24.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
59.83
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
-0.00
1.0
1.2
—
—
—
0
0
5
56
0.89
-0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
305.00
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
1.33
—
0
6
6
68
0.88
-0.00
1.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
23.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
761.60
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
3.71
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint P16_BACTERIAL_SEPSIS_NEWBO and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| P16_BACTERIAL_SEPSIS_NEWBO | 1.309 [1.03, 1.66] | 0.027 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 75 out of 15045 males with P16_BACTERIAL_SEPSIS_NEWBO died.
Mortality risk
Mortality risk for people of age
years, who have P16_BACTERIAL_SEPSIS_NEWBO.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.274% |
| 5 | No data | 1.604% |
| 10 | No data | 3.955% |
| 15 | No data | 7.652% |
| 20 | No data | 12.738% |
Relationships between endpoints
↥Index endpoint: P16_BACTERIAL_SEPSIS_NEWBO – Bacterial sepsis of newborn
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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