No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
618 |
6. Filter based on genotype QC (FinnGen only) |
542 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other disorders of choroid
based on the number of shared cases.
Similar with more cases:
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4103 | 2132 | 1941 |
| Only index persons | 3629 | 1908 | 1721 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.05 |
| Only index persons | 0.07 | 0.07 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 63.92 | 67.31 | 60.08 |
| Only index persons | 62.24 | 65.65 | 58.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 542 | 284 | 258 |
| Unadjusted period prevalence (%) | 0.11 | 0.10 | 0.12 |
| Median age at first event (years) | 63.38 | 61.95 | 64.96 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 570
- Matched controls
- 5700
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H31.0
ICD-10 Finland
Chorioretinal scars
+∞
149.8
137
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
12.6
142.2
161
173
H31.3
ICD-10 Finland
Choroidal haemorrhage and rupture
+∞
126.9
117
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
14.9
117.4
113
93
XCW99
NOMESCO Finland
Other investigative procedure of eye
10.2
114.9
150
193
XCK10
NOMESCO Finland
Photography of fundus of eye
9.5
112.2
157
220
WX140
NOMESCO Finland
Parabulbar anesthesy
19.3
105.1
86
52
H31.4
ICD-10 Finland
Choroidal detachment
+∞
95.6
89
*
H31.9
ICD-10 Finland
Disorder of choroid, unspecified
+∞
85.6
80
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.7
80.0
197
483
H31.8
ICD-10 Finland
Other specified disorders of choroid
+∞
73.6
69
*
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
19.1
70.5
57
33
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
121.2
69.7
74
7
S01EA05
ATC
brimonidine; ophthalmic
13.4
68.0
67
56
S01EC01
ATC
acetazolamide; systemic
15.8
67.4
60
42
XCD10
NOMESCO Finland
Electrophysiological examination of eye
14.7
66.6
62
47
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
22.7
64.4
48
23
S01ED51
ATC
timolol, combinations; ophthalmic
6.6
63.3
117
216
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.7
60.9
185
528
XCK00
NOMESCO Finland
Perimetry
7.7
60.5
93
141
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
111.5
56.0
60
6
H33.0
ICD-10 Finland
Retinal detachment with retinal break
496.6
47.0
46
*
S01ED01
ATC
timolol; ophthalmic
8.8
46.0
61
77
H43.1
ICD-10 Finland
Vitreous haemorrhage
18.6
43.2
35
20
114
Kela drug reimbursment
Glaucoma
4.6
41.4
114
294
H31.2
ICD-10 Finland
Hereditary choroidal dystrophy
+∞
40.1
38
*
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
92.9
39.4
43
5
S01EC03
ATC
dorzolamide; ophthalmic
12.7
36.2
36
30
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.9
34.3
274
1373
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
48.9
34.2
41
9
XCD20
NOMESCO Finland
Photoangiography of eye
98.8
34.1
37
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.9
33.9
280
1427
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
67.7
33.4
38
6
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
7.3
32.8
50
74
S01EX03, ,
ATC
9.7
32.5
39
43
XCH00
NOMESCO Finland
Eye pressure measurement
6.4
32.4
57
98
S01EC04
ATC
brinzolamide; ophthalmic
6.0
31.3
58
105
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
330.1
31.1
31
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.2
30.8
92
250
H31.1
ICD-10 Finland
Choroidal degeneration
+∞
30.5
29
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.6
27.9
309
1775
H26.4
ICD-10 Finland
After-cataract
3.6
26.6
99
313
H33.3
ICD-10 Finland
Retinal breaks without detachment
141.4
25.8
27
*
CKD40
NOMESCO Finland
Endophotocoagulation of retina
+∞
24.1
23
*
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
23.3
23.3
33
15
S01EE01
ATC
latanoprost; ophthalmic
4.0
23.1
71
196
H25.1
ICD-10 Finland
Senile nuclear cataract
2.4
22.0
226
1220
S01BC03
ATC
diclofenac; ophthalmic
8.4
21.9
29
36
CKC10
NOMESCO Finland
Local photocoagulation of retina
228.4
21.7
22
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
5.5
21.6
43
83
CKC12
NOMESCO Finland
Photocoagulation of retina
38.8
20.9
26
7
S01EE04
ATC
travoprost; ophthalmic
7.4
19.7
29
41
S01EE05
ATC
tafluprost; ophthalmic
5.0
19.5
43
91
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
196.2
18.6
19
*
ZXA10
NOMESCO Finland
Bilateral
2.5
18.5
137
630
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
4.1
17.8
51
133
Z3229
NOMESCO Finland
Other healthcare associate professional
3.2
17.4
77
269
S01EA03
ATC
apraclonidine; ophthalmic
20.0
17.0
25
13
H35.6
ICD-10 Finland
Retinal haemorrhage
+∞
16.7
16
*
H35.7
ICD-10 Finland
Separation of retinal layers
+∞
16.7
16
*
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
92.8
16.6
18
*
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
92.8
16.6
18
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
34.5
15.8
20
6
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
+∞
15.7
15
*
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
19.9
15.7
23
12
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
87.5
15.6
17
*
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
+∞
14.6
14
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.5
14.2
103
464
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
43.7
14.2
17
*
CKD15
NOMESCO Finland
Injection of vitreous substitute
+∞
13.6
13
*
S01EE03
ATC
bimatoprost; ophthalmic
5.4
13.6
27
52
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
143.3
13.5
14
*
H40.9
ICD-10 Finland
Glaucoma, unspecified
5.4
13.1
26
50
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
17.8
12.6
19
11
CKD20
NOMESCO Finland
Removal of vitreous body substitute
+∞
12.5
12
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
+∞
12.5
12
*
H35.8
ICD-10 Finland
Other specified retinal disorders
+∞
12.5
12
*
CHD00
NOMESCO Finland
Laser trabeculoplasty
10.0
12.3
24
25
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
12.1
11.9
21
18
H35.9
ICD-10 Finland
Retinal disorder, unspecified
66.3
11.6
13
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
66.3
11.6
13
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
14.0
11.5
19
14
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
122.4
11.5
12
*
H35.4
ICD-10 Finland
Peripheral retinal degeneration
122.4
11.5
12
*
S01BA07
ATC
fluorometholone; ophthalmic
9.5
11.1
22
24
WX002
NOMESCO Finland
Sedation and analgesia
2.1
10.9
126
685
ZXA05
NOMESCO Finland
Left side
1.9
10.7
159
944
H27.0
ICD-10 Finland
Aphakia
22.0
10.7
15
7
H35.37
ICD-10 Finland
Macular holes
112.0
10.5
11
*
C69.32
ICD-10 Finland
Malignant tumor of the chorioidea melanoma
112.0
10.5
11
*
WX142
NOMESCO Finland
Sub-tenon anesthesy
33.2
10.4
13
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
19.2
10.3
15
8
CHD99
NOMESCO Finland
Other filtering operation
19.2
10.3
15
8
S01EC54
ATC
brinzolamide, combinations; ophthalmic
8.7
10.1
21
25
H26.2
ICD-10 Finland
Complicated cataract
14.9
10.0
16
11
H26.02
ICD-10 Finland
Presenil cataract
4.8
9.8
22
47
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
20.5
9.8
14
7
CK2M4
NOMESCO Finland
Macular light layer imaging (OCT)
56.0
9.7
11
*
CJF00
NOMESCO Finland
Secondary implantation of artificial lens in anterior chamber
101.7
9.4
10
*
C69.30
ICD-10 Finland
Malignant tumor of the chorioidea without histology
30.6
9.4
12
*
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
30.6
9.4
12
*
H35.36
ICD-10 Finland
Macular cyst
+∞
9.4
9
*
CK9G4
NOMESCO Finland
Iridocyanine green angiography (ICGA) of choroid and retina
+∞
9.4
9
*
H34.1
ICD-10 Finland
Central retinal artery occlusion
+∞
9.4
9
*
CHC05
NOMESCO Finland
Iridotomy
7.5
9.3
21
29
S01ED02
ATC
betaxolol; ophthalmic
8.5
9.1
19
23
H27.1
ICD-10 Finland
Dislocation of lens
19.0
9.0
13
7
S01BA04
ATC
prednisolone; ophthalmic
4.4
8.9
22
51
H33.5
ICD-10 Finland
Other retinal detachments
24.5
8.9
12
5
H53.1
ICD-10 Finland
Subjective visual disturbances
2.8
8.9
47
180
XCW10
NOMESCO Finland
Assessment of vision
8.4
8.6
18
22
H40.0
ICD-10 Finland
Glaucoma suspect
2.5
8.6
54
226
CKD60
NOMESCO Finland
Anterior vitrectomy
9.2
8.6
17
19
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
3.5
8.5
29
86
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.1
8.5
83
422
CM2X4
NOMESCO Finland
Follow-up OCT of age-related macular degeneration lesions
91.4
8.4
9
*
CKC70
NOMESCO Finland
Circular buckling of sclera
+∞
8.4
8
*
H30.9
ICD-10 Finland
Chorioretinal inflammation, unspecified
+∞
8.4
8
*
H33.2
ICD-10 Finland
Serous retinal detachment
+∞
8.4
8
*
H3600, E113,
ICD-10 Finland
+∞
8.4
8
*
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
3.6
8.3
27
77
H57.1
ICD-10 Finland
Ocular pain
3.5
8.3
28
82
ZXA00
NOMESCO Finland
Right side
1.8
8.3
163
1048
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
4.3
8.3
21
50
CKE65
NOMESCO Finland
Removal of brachytherapeutic plate from eye
33.9
8.1
10
*
CKE60
NOMESCO Finland
Brachytherapy of choroid and retina
33.9
8.1
10
*
Z3231
NOMESCO Finland
Registered nurse
1.7
7.6
160
1044
H25.8
ICD-10 Finland
Other senile cataract
2.1
7.6
74
375
CHD35
NOMESCO Finland
Laser goniopuncture
13.6
7.4
12
9
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
7.0
7.3
17
25
H30.2
ICD-10 Finland
Posterior cyclitis
+∞
7.3
7
*
H3603, E103,
ICD-10 Finland
+∞
7.3
7
*
3636A
ICD-9 Finland
Chorioretinal inflammations and scars and other disorders of choroid, Choroidal haemorrhage and rupture
+∞
7.3
7
*
H36.00
ICD-10 Finland
Diabetic background retinopathy
+∞
7.3
7
*
S01BC05
ATC
ketorolac; ophthalmic
2.8
7.0
34
125
CA1ME
NOMESCO Finland
Ultrasound oculometry
14.0
6.9
11
8
H53.9
ICD-10 Finland
Visual disturbance, unspecified
3.1
6.9
28
93
H43.8
ICD-10 Finland
Other disorders of vitreous body
2.2
6.6
54
255
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
70.6
6.4
7
*
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
70.6
6.4
7
*
3708
FHL
Trabeculectomy or equivalent
70.6
6.4
7
*
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
70.6
6.4
7
*
H54.1
ICD-10 Finland
Severe visual impairment, binocular
70.6
6.4
7
*
H02AB06
ATC
prednisolone; systemic
1.6
6.4
267
2050
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
8.3
6.4
13
16
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.3
6.3
47
213
ZXE00
NOMESCO Finland
One hour or less
1.6
6.3
208
1514
CK2Y4
NOMESCO Finland
OCT video recording of ocular fundus
+∞
6.3
6
*
H33.4
ICD-10 Finland
Traction detachment of retina
+∞
6.3
6
*
H3601, E113,
ICD-10 Finland
+∞
6.3
6
*
H30.1
ICD-10 Finland
Disseminated chorioretinal inflammation
+∞
6.3
6
*
L04AX01
ATC
azathioprine; systemic
3.0
6.2
27
93
Z2221
NOMESCO Finland
Medical doctor
1.7
6.2
146
975
S01EA02
ATC
dipivefrine; ophthalmic
12.7
6.1
10
8
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
132
781
1.90
8.81
3.4
2.4
2.22
2.29
g/l
0.75
124
715
139
848
1.85
8.40
3.5
2.4
11.86
12.17
umol/l
0.21
134
785
124
730
1.89
8.37
3.4
2.4
21.49
21.59
%
0.03
119
677
192
1317
1.69
7.62
2.7
2.2
2.80
3.06
mg/l
0.66
166
1125
283
2146
1.63
7.57
3.9
3.0
127.48
128.71
ug/l
0.04
263
1998
17
40
4.35
6.79
1.1
1.1
—
—
—
0
0
178
1248
1.62
6.28
3.6
2.8
349.64
350.21
umol/l
0.02
159
1101
221
1640
1.57
6.10
4.1
3.4
65.32
87.17
e6/l
0.19
174
1273
14
22
6.49
5.89
1.8
3.5
2316.50
1217.50
u/ml
0.33
14
22
334
2734
1.54
5.79
11.7
9.4
4.21
4.15
e9/l
0.19
292
2384
12
16
7.63
5.65
1.0
1.1
—
—
—
0
0
206
1530
1.54
5.54
3.3
2.5
59.02
62.22
u/l
0.29
195
1429
312
2547
1.50
5.27
9.6
7.0
1.21
1.21
mmol/l
0.96
271
2203
410
3546
1.56
5.25
4.5
4.3
14.99
14.92
pmol/l
0.27
376
3252
279
2228
1.49
5.24
6.9
4.8
35.64
35.44
g/l
0.24
257
2085
188
1396
1.52
4.96
4.0
3.3
0.25
0.45
e6/l
1.11
145
1030
16
47
3.47
4.78
1.5
1.4
—
—
—
0
0
159
1152
1.53
4.66
3.6
2.7
4.81
5.48
e6/l
0.33
145
1060
317
2639
1.45
4.58
5.4
4.1
0.00
0.56
estimate
0.50
75
537
315
2621
1.45
4.55
5.4
4.1
0.00
2.86
estimate
0.50
81
568
312
2594
1.45
4.51
5.3
4.1
0.00
0.00
estimate
-0.00
79
552
121
832
1.58
4.47
4.3
3.3
0.82
0.82
mmol/l
0.21
112
789
507
4687
1.74
4.20
28.4
20.5
3.99
3.99
mmol/l
0.03
496
4590
411
3632
1.47
4.09
11.5
8.0
85.97
78.77
u/l
0.92
392
3437
286
2368
1.42
4.08
19.8
15.9
1.29
1.29
inr
0.09
237
1978
205
1601
1.44
4.04
4.5
3.1
30.52
32.69
u/l
0.51
194
1511
311
2621
1.41
3.96
7.7
6.3
12.06
11.69
umol/l
0.16
303
2505
505
4679
1.70
3.94
27.9
20.4
139.73
139.62
mmol/l
0.42
495
4591
10
19
5.34
3.84
1.1
1.0
1761.40
1395.00
miu/ml
—
10
19
422
3770
1.46
3.79
29.3
21.0
13.85
13.72
%
1.02
417
3732
259
2131
1.39
3.72
2.9
2.4
78.12
78.89
nmol/l
0.15
237
1902
120
856
1.51
3.72
3.1
3.0
1.25
1.02
e6/l
0.29
62
463
463
4219
1.52
3.71
5.9
5.3
1.88
1.98
mu/l
1.10
429
3878
472
4320
1.54
3.69
7.7
6.4
40.68
39.34
mmol/mol
2.43
443
4039
100
687
1.55
3.68
2.2
1.8
—
—
—
0
0
515
4816
1.72
3.63
30.2
22.4
83.18
79.62
umol/l
1.15
508
4751
337
2905
1.39
3.62
6.5
5.0
6.74
6.68
mmol/l
0.22
327
2763
95
656
1.54
3.41
2.2
1.9
—
—
—
0
0
44
249
1.83
3.35
1.8
1.8
1.63
1.59
g/l
0.09
38
225
72
472
1.60
3.24
2.6
1.8
357.19
390.17
nmol/l
0.64
67
434
471
4346
1.48
3.16
21.9
16.6
75.85
77.78
ml/min/173m2
1.10
444
4055
76
509
1.57
3.13
4.3
3.6
—
—
—
0
0
138
1045
1.42
3.11
2.4
1.7
1.19
1.38
mg/l
0.45
110
825
122
905
1.44
3.08
2.3
1.9
—
—
—
0
0
6
8
7.56
3.06
1.3
1.0
—
—
—
0
0
207
1684
1.36
3.03
4.3
3.1
7.10
7.58
mmol/l
1.01
182
1439
7
12
5.89
3.03
1.1
1.3
—
—
—
0
0
108
787
1.46
2.99
3.2
3.2
2.49
2.53
e6/l
0.02
50
395
35
192
1.88
2.95
1.8
3.3
0.14
0.80
g/l
2.45
30
168
203
1654
1.35
2.92
5.2
3.8
7.90
8.83
mg/mmol
0.15
129
1044
62
405
1.60
2.84
5.0
3.8
1.22
1.23
mmol/l
0.38
55
352
264
2244
1.33
2.84
3.0
2.8
—
—
estimate
—
0
0
390
3510
1.35
2.81
5.9
4.3
14.85
13.17
mm/h
1.07
373
3258
478
4451
1.46
2.79
5.5
5.1
4.50
4.57
mmol/l
0.70
438
4127
238
1999
1.33
2.76
5.3
4.0
28.33
66.42
ng/l
0.78
181
1476
120
905
1.41
2.75
1.9
1.7
1133.57
1173.94
nmol/l
0.18
86
673
11
34
3.28
2.74
2.0
1.3
—
—
—
0
0
174
1397
1.35
2.73
5.1
3.6
0.02
0.07
estimate
0.45
63
435
35
198
1.82
2.70
1.9
3.0
11.06
10.19
g/l
0.46
30
180
60
395
1.58
2.67
1.8
1.6
—
—
—
0
0
488
4575
1.46
2.62
24.5
16.9
23.26
24.99
mg/l
0.68
414
3832
267
2293
1.31
2.60
9.0
6.3
1.21
1.21
mmol/l
0.78
254
2122
9
25
3.64
2.58
1.3
2.2
—
—
—
0
0
9
25
3.64
2.58
1.3
2.2
—
—
—
0
0
15
62
2.46
2.56
1.4
1.5
30.80
32.63
pg
0.81
15
62
26
136
1.96
2.54
1.3
1.7
—
—
—
0
0
505
4772
1.51
2.54
16.0
12.0
25.66
25.74
u/l
0.04
489
4638
473
4418
1.41
2.51
5.3
5.0
1.42
1.46
mmol/l
1.28
430
4079
87
630
1.45
2.49
7.7
7.2
0.92
0.98
mmol/l
0.05
60
511
231
1955
1.31
2.47
5.7
4.1
0.03
0.04
estimate
0.05
65
454
259
2229
1.30
2.43
2.3
2.2
100.35
95.71
pmol/l
0.68
138
1175
517
4919
1.55
2.41
34.8
25.7
245.15
247.09
e9/l
0.27
505
4830
98
730
1.41
2.41
7.1
6.7
104.62
103.97
mmol/l
0.58
98
730
23
118
1.99
2.38
7.6
5.9
105.00
105.10
mmol/l
0.04
23
107
517
4921
1.54
2.38
34.7
25.6
4.39
4.45
e12/l
1.61
503
4822
517
4921
1.54
2.38
35.3
26.1
39.41
40.08
%
1.78
512
4866
517
4921
1.54
2.38
34.7
25.6
91.67
91.33
fl
0.83
512
4870
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
30
171
1.80
2.29
4.8
2.5
0.37
0.38
iu/ml
0.02
19
95
13
53
2.49
2.29
1.3
1.3
—
—
—
0
0
5
9
5.59
2.21
35.0
7.4
7.78
5.04
kpa
—
5
9
5
9
5.59
2.21
35.4
7.6
5.54
6.02
kpa
—
5
9
64
448
1.48
2.18
1.9
3.2
66.81
66.40
g/l
0.17
57
413
481
4537
1.39
2.12
6.4
5.8
2.61
2.65
mmol/l
0.45
441
4194
188
1582
1.28
2.02
2.7
2.1
174.89
209.74
u/l
0.34
180
1499
204
1740
1.27
1.96
4.5
3.3
2.35
2.36
mmol/l
0.44
190
1571
131
1057
1.31
1.93
3.4
2.9
2.45
2.46
mmol/l
0.54
117
944
102
794
1.35
1.93
1.3
1.3
8.42
13.54
u/ml
0.56
46
285
72
531
1.41
1.89
4.6
3.7
1.69
1.96
mmol/l
0.30
62
458
12
52
2.34
1.89
1.3
1.3
2.80
5.53
u/ml
—
5
19
40
262
1.57
1.87
4.1
3.3
23.55
25.31
mmol/l
2.19
40
253
469
4429
1.33
1.87
5.8
5.2
6.16
5.96
mmol/l
2.18
432
4050
45
305
1.52
1.82
4.2
3.7
45.32
47.50
%
0.24
45
298
132
1075
1.30
1.82
1.8
1.7
61165483.79
13190968.68
pmol/l
0.35
103
887
13
60
2.19
1.79
2.7
2.0
3.51
66.08
u/ml
0.50
13
60
6
18
3.36
1.75
3.3
2.2
111.83
97.83
%
—
6
18
56
404
1.43
1.67
3.7
3.6
109.40
81.18
ng/l
0.80
50
352
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
5
14
3.59
1.62
1.4
3.0
255.00
130.14
%
—
5
14
329
3003
1.23
1.61
4.1
3.2
52.89
49.83
u/l
0.29
306
2818
7
26
2.71
1.58
1.0
1.0
—
—
—
0
0
20
114
1.78
1.58
1.6
1.6
212.89
312.12
mu/l
2.12
20
109
215
1883
1.23
1.57
1.9
1.9
1.35
1.34
mmol/l
0.07
184
1587
449
4246
1.27
1.55
4.6
4.2
1.31
1.29
mmol/l
0.32
404
3892
17
93
1.85
1.53
2.6
2.1
3248.04
8310.03
u/l
—
7
34
13
65
2.02
1.49
1.2
1.4
—
—
—
0
0
25
155
1.64
1.49
3.8
3.2
1.68
1.59
mmol/l
0.18
25
150
39
269
1.48
1.48
1.5
1.4
—
—
—
0
0
173
1490
1.23
1.47
5.7
4.2
0.00
0.01
estimate
0.74
71
514
23
140
1.67
1.47
1.5
1.6
—
—
—
0
0
20
117
1.74
1.47
1.8
2.0
1.55
55.84
iu/l
—
9
46
7
28
2.52
1.45
11.6
3.1
0.71
0.93
index
—
7
28
27
174
1.58
1.40
2.6
3.6
1.10
2.73
ratio
1.99
16
97
71
551
1.33
1.39
3.4
2.6
9.35
8.84
umol/l
0.07
62
492
12
60
2.02
1.39
1.0
1.1
1.66
1.47
g/l
0.53
12
54
6
23
2.63
1.37
1.2
1.0
—
—
—
0
0
288
2623
1.20
1.36
3.2
2.9
—
—
—
0
0
136
1151
1.24
1.35
5.4
4.4
1.02
1.02
kg/l
1.07
94
767
21
129
1.65
1.31
1.5
1.6
17291.67
18767.49
e6/l
0.06
15
90
6
24
2.52
1.30
1.0
1.2
72.33
75.05
u/l
—
6
24
23
146
1.60
1.28
1.2
1.3
—
—
—
0
0
8
36
2.24
1.24
1.4
1.2
—
—
—
0
0
8
36
2.24
1.24
1.4
1.2
—
—
—
0
0
9
45
2.02
1.23
1.1
1.1
—
—
—
0
0
137
1174
1.22
1.21
2.6
2.4
—
—
—
0
0
6
26
2.32
1.19
2.2
4.4
89.83
188.15
nmol/l
—
6
26
28
190
1.50
1.18
3.4
2.1
700.23
292.89
ug/l
0.39
28
183
122
1037
1.22
1.17
1.3
1.3
0.96
1.28
u/ml
0.42
46
282
44
327
1.37
1.16
1.6
1.8
—
—
—
0
0
5
20
2.51
1.15
1.0
1.3
5.68
7.06
mmol/l
—
5
20
7
30
2.35
1.12
2.1
3.9
—
—
—
0
0
16
96
1.69
1.11
1.4
1.6
—
—
—
0
0
5
21
2.39
1.09
2.4
1.2
—
—
—
0
0
8
41
1.96
1.09
1.0
1.1
—
81.83
—
0
6
8
41
1.96
1.09
1.4
1.1
—
—
—
0
0
50
387
1.32
1.04
3.0
2.8
57.26
64.49
ml/min/173m2
0.63
23
173
116
996
1.21
1.01
4.8
4.2
218.81
294.40
ng/l
0.30
89
812
139
1215
1.19
1.00
5.4
4.0
89.68
88.32
%
0.25
133
1191
7
35
2.01
1.00
1.4
1.2
—
—
—
0
0
7
35
2.01
1.00
1.4
1.2
—
—
—
0
0
9
49
1.85
0.99
1.9
2.3
—
—
—
0
0
16
100
1.62
0.97
1.4
1.4
—
—
—
0
0
16
100
1.62
0.97
1.4
1.4
—
—
—
0
0
13
77
1.70
0.96
1.5
1.2
252.14
248.09
u/ml
—
7
44
100
852
1.21
0.95
1.4
1.3
42.57
36.71
iu/ml
0.20
31
265
27
193
1.42
0.92
2.1
2.2
8.63
8.42
iu/ml
—
7
54
57
461
1.26
0.88
3.1
2.4
0.34
0.52
e6/l
0.26
52
441
8
43
1.87
0.87
1.5
1.3
—
—
—
0
0
22
153
1.46
0.87
1.8
3.3
0.00
0.00
g/l
-0.00
22
143
8
44
1.83
0.86
1.1
1.1
—
—
—
0
0
8
45
1.79
0.84
1.4
1.2
—
—
—
0
0
8
45
1.79
0.84
1.3
1.2
—
—
—
0
0
181
1643
1.15
0.81
3.9
3.3
1946.55
1405.26
ng/l
1.50
161
1419
16
106
1.52
0.79
1.1
1.6
3.33
18.56
e6/l
—
9
84
171
1550
1.15
0.78
1.8
1.7
19.62
20.20
nmol/l
0.21
149
1317
16
107
1.51
0.77
1.2
1.6
112.91
1205.37
e6/l
0.54
11
86
25
184
1.38
0.75
1.2
1.3
—
—
—
0
0
5
24
2.09
0.74
1.0
1.2
15.00
18.15
u/l
—
5
24
7
38
1.85
0.73
1.0
1.1
—
—
—
0
0
22
298
0.73
0.73
2.1
1.8
3.90
3.43
mmol/l
0.77
14
225
10
60
1.68
0.72
7.4
4.5
—
—
—
0
0
9
57
1.59
0.71
2.8
1.8
—
—
—
0
0
30
386
0.76
0.71
1.7
1.5
—
—
—
0
0
5
27
1.86
0.68
1.6
1.7
—
—
—
0
0
16
111
1.45
0.66
1.3
1.2
0.94
0.88
g/l
0.40
16
111
5
29
1.73
0.64
1.6
1.7
—
—
—
0
0
21
155
1.37
0.64
2.0
2.2
—
—
—
0
0
8
49
1.64
0.62
1.9
1.4
—
—
—
0
0
5
30
1.67
0.61
1.4
1.6
142.60
79.72
ng/l
—
5
30
8
51
1.58
0.60
1.1
1.1
—
—
—
0
0
15
105
1.44
0.60
1.1
1.1
1.49
1.54
g/l
0.27
15
105
10
64
1.57
0.59
1.5
1.3
468.60
263.86
pmol/l
—
10
59
6
35
1.72
0.58
1.3
1.2
—
—
—
0
0
5
89
0.56
0.56
1.4
1.2
155.04
21.20
u/l
—
5
78
23
177
1.31
0.55
4.3
2.9
—
—
—
0
0
6
39
1.54
0.53
1.7
1.7
—
—
—
0
0
52
444
1.19
0.53
3.3
2.4
34.36
35.25
u/l
0.06
44
377
16
118
1.37
0.50
1.3
1.2
—
—
—
0
0
6
41
1.47
0.50
1.2
2.0
13.17
13.19
%
—
6
41
7
49
1.43
0.46
1.9
1.7
—
—
—
0
0
12
86
1.40
0.45
1.5
1.6
—
—
—
0
0
16
121
1.33
0.44
1.8
1.5
—
—
—
0
0
27
220
1.24
0.44
1.0
1.0
—
—
—
0
0
20
157
1.28
0.44
1.2
1.3
—
—
—
0
0
5
31
1.62
0.43
1.4
1.3
—
—
—
0
0
5
31
1.62
0.43
1.4
1.3
—
—
—
0
0
17
131
1.31
0.42
1.7
1.4
—
—
—
0
0
5
32
1.57
0.42
1.6
1.7
—
—
—
0
0
8
57
1.41
0.42
1.3
1.4
—
—
—
0
0
8
58
1.38
0.41
1.3
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.7
—
—
—
0
0
33
280
1.19
0.38
1.2
1.2
95.03
124.84
u/ml
0.24
13
109
15
116
1.30
0.37
1.3
1.5
—
—
—
0
0
5
37
1.35
0.37
1.0
1.1
73.00
100.11
pmol/l
—
5
37
51
575
0.88
0.37
4.3
4.8
31.17
32.60
%
0.32
29
374
35
406
0.85
0.37
2.3
2.0
3.81
3.47
ratio
0.93
28
333
9
70
1.29
0.37
1.1
1.7
—
—
—
0
0
23
189
1.23
0.36
2.3
2.2
—
—
—
0
0
6
46
1.31
0.33
1.5
1.6
—
—
—
0
0
169
1606
1.07
0.31
6.0
5.5
2.37
2.57
ug/l
0.17
151
1446
17
138
1.24
0.30
11.7
3.0
1.33
1.65
index
0.20
12
73
7
54
1.30
0.30
5.1
3.5
2.83
5.97
nmol/l
—
7
54
35
307
1.15
0.29
10.2
9.3
23.48
24.34
mmol/l
0.66
35
301
7
57
1.23
0.29
1.3
1.4
—
—
—
0
0
30
343
0.87
0.28
2.2
2.0
—
—
—
0
0
8
62
1.29
0.28
2.6
1.6
—
—
—
0
0
8
65
1.23
0.27
2.0
1.6
—
—
—
0
0
135
1282
1.07
0.26
5.4
4.6
22.60
21.62
%
0.34
67
631
12
149
0.80
0.26
2.8
1.9
37.67
39.49
nmol/l
0.16
12
144
53
484
1.10
0.25
1.9
1.8
1.58
1.51
%
0.27
44
425
13
105
1.24
0.25
1.7
1.5
—
—
—
0
0
33
293
1.13
0.24
4.8
3.8
1.77
2.05
mmol/l
0.18
26
217
34
379
0.89
0.23
2.6
2.1
—
—
—
0
0
47
429
1.10
0.23
3.5
3.3
202.39
224.39
ng/l
0.16
41
398
16
135
1.19
0.21
2.1
1.5
—
—
—
0
0
5
42
1.19
0.21
1.2
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
12
145
0.82
0.21
1.6
1.5
—
—
—
0
0
8
105
0.76
0.21
1.3
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
2.6
—
2.84
—
0
5
6
49
1.23
0.20
1.8
1.6
54.16
50.44
ug/l
—
6
49
47
433
1.09
0.20
2.6
2.4
11.94
6.85
ug/l
0.42
40
382
77
725
1.07
0.20
1.8
1.6
—
—
—
0
0
7
59
1.19
0.18
1.4
1.4
—
—
—
0
0
7
61
1.15
0.17
1.4
1.4
—
—
—
0
0
7
61
1.15
0.17
1.4
1.4
—
—
—
0
0
20
226
0.88
0.17
1.6
1.3
—
—
—
0
0
7
62
1.13
0.17
1.0
1.1
—
13.12
—
0
17
11
92
1.20
0.16
1.5
1.7
4.05
4.56
mmol/24h
0.28
11
84
16
144
1.11
0.10
2.2
1.5
—
—
—
0
0
98
950
1.04
0.10
3.3
3.2
1.02
0.80
ug/l
0.40
59
623
14
156
0.89
0.10
1.5
1.1
—
—
—
0
0
5
44
1.14
0.10
1.2
1.2
9.80
10.54
u/l
—
5
39
5
46
1.09
0.09
8.0
2.6
2086.00
784.57
mg
—
5
46
19
175
1.09
0.08
1.4
1.9
—
—
—
0
0
9
104
0.86
0.06
1.0
1.1
—
5.21
—
0
14
61
594
1.03
0.05
1.4
1.5
—
—
—
0
0
11
100
1.10
0.05
2.0
1.5
—
—
—
0
0
10
110
0.91
0.05
1.1
1.3
—
—
—
0
0
20
189
1.06
0.04
1.5
2.0
—
—
—
0
0
57
556
1.03
0.04
8.3
7.6
—
—
—
0
0
54
527
1.03
0.04
3.9
4.2
30.19
15.16
ug/l
0.22
45
447
19
200
0.95
0.04
2.3
1.4
0.24
0.30
mg/l
—
9
82
15
158
0.95
0.02
1.5
1.1
—
—
—
0
0
15
144
1.04
0.00
1.8
1.7
—
—
—
0
0
11
114
0.96
0.00
1.5
1.3
4.15
8.84
u/l
2.81
11
91
6
59
1.02
0.00
1.0
1.1
—
2.18
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
62
0.97
-0.00
1.8
1.8
—
—
—
0
0
12
120
1.00
-0.00
1.1
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
78
0.90
-0.00
1.1
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
44.80
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
85
0.94
-0.00
2.5
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
7
69
1.01
-0.00
1.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
0.60
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
53
0.94
-0.00
2.4
1.4
0.18
0.18
nmol/l
—
5
39
0
9
0.00
-0.00
0.0
1.0
—
57.58
—
0
9
6
63
0.95
-0.00
2.3
1.5
0.67
0.63
nmol/l
—
6
58
Mortality – FinRegistry
↥Association
Association between endpoint H7_CHOROIDOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHOROIDOTH | 1.061 [0.92, 1.22] | 0.4 |
| Birth year | 0.998 [0.99, 1.01] | 0.675 |
During the follow-up period (1.1.1998 — 31.12.2019), 525 out of 1781 females with H7_CHOROIDOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHOROIDOTH | 1.09 [0.93, 1.27] | 0.272 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 417 out of 1549 males with H7_CHOROIDOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_CHOROIDOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.112% | 0.209% |
| 5 | 0.689% | 1.294% |
| 10 | 1.593% | 3.192% |
| 15 | 3.182% | 5.938% |
| 20 | 5.824% | 10.166% |
Relationships between endpoints
↥Index endpoint: H7_CHOROIDOTH – Other disorders of choroid
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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