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Chorioretinal scars

DOID Endpoint Browser PheWeb

H7_CHORSCAR

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H31.0
  • Hospital discharge: ICD-9 — 3633
  • Cause of death: ICD-10 — H31.0
  • Cause of death: ICD-9 — 3633

2 out of 7 registries used, show all original rules.

151

4. Check minimum number of events

None

151

5. Include endpoints

None

151

6. Filter based on genotype QC (FinnGen only)

131

Control definitions (FinnGen only)

Control exclude
H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H31
Name in latin
Cicatrices chorioretinales

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 911 460 444
Only index persons 847 431 416
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 54.06 57.19 50.81
Only index persons 53.76 57.06 50.34

-FinnGen-

Key figures

All Female Male
Number of individuals 131 78 53
Unadjusted period prevalence (%) 0.03 0.03 0.02
Median age at first event (years) 60.37 60.58 60.06

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
138
Matched controls
1380
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H31.0
ICD-10 Finland
Chorioretinal scars
+∞
196.2
137
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
7.5
18.5
30
49
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
7.1
17.0
29
50
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
8.4
16.2
23
32
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
65.2
10.8
12
*
XCK10
NOMESCO Finland
Photography of fundus of eye
4.6
10.3
28
73
H33.0
ICD-10 Finland
Retinal detachment with retinal break
+∞
9.5
9
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
39.5
9.2
11
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
3.7
8.2
30
97
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
84.4
7.5
8
*
H33.3
ICD-10 Finland
Retinal breaks without detachment
+∞
7.4
7
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
56
332
2.16
4.46
3.8
2.9
338.84
340.51
umol/l
0.05
49
293
62
417
1.88
3.25
4.6
3.4
95.16
207.52
e6/l
0.28
47
313
45
272
1.97
3.24
2.8
2.0
1.03
1.46
mg/l
0.65
38
217
55
359
1.88
3.14
3.9
3.3
0.17
0.52
e6/l
1.38
42
256
73
529
1.81
2.93
4.7
3.6
6.32
6.25
ph
0.18
41
289
55
366
1.84
2.92
4.2
3.0
—
0.20
—
0
10
76
567
1.76
2.68
19.7
12.1
0.00
0.00
e9/l
0.72
62
455
66
480
1.72
2.50
5.8
4.1
34.05
99.81
e6/l
1.06
51
325
59
418
1.72
2.44
8.6
7.0
—
—
—
0
0
6
12
5.17
2.43
1.2
1.1
—
—
—
0
0
56
396
1.70
2.31
7.1
3.9
7.39
7.40
ph
0.43
40
278
5
9
5.71
2.23
1.2
1.4
—
—
—
0
0
83
659
1.65
2.14
5.6
3.9
0.00
0.00
estimate
-0.00
20
140
5
10
5.14
2.09
2.4
2.7
—
—
—
0
0
83
669
1.60
1.94
5.6
3.9
0.00
11.36
estimate
0.50
21
143
32
203
1.75
1.91
3.5
3.2
3.59
2.44
e6/l
0.29
11
90
52
376
1.61
1.90
4.6
3.2
—
—
—
0
0
72
563
1.58
1.90
8.0
4.7
36.09
35.66
g/l
0.28
66
541
107
921
1.72
1.90
4.7
4.5
15.03
14.81
pmol/l
0.47
99
853
83
672
1.59
1.88
5.6
3.9
0.00
0.00
estimate
-0.00
21
130
20
110
1.96
1.85
2.3
3.7
68.96
72.62
e9/l
0.24
14
80
79
635
1.57
1.82
12.6
7.2
1.21
1.21
mmol/l
0.42
68
545
71
559
1.56
1.78
2.4
2.2
89.83
94.66
pmol/l
0.25
32
286
25
151
1.80
1.75
4.4
3.5
1.79
1.85
%
0.17
25
135
26
161
1.76
1.68
1.1
1.2
—
—
—
0
0
63
492
1.52
1.59
2.0
2.0
1.28
1.36
mmol/l
0.32
50
412
15
81
1.96
1.47
3.7
6.4
24.66
24.44
mmol/l
0.15
15
81
12
61
2.06
1.37
2.3
1.9
—
—
—
0
0
9
42
2.22
1.36
1.2
1.1
—
—
—
0
0
85
722
1.46
1.33
14.5
10.9
4.20
4.13
e9/l
0.12
73
627
6
24
2.57
1.32
2.2
1.5
—
—
—
0
0
62
498
1.44
1.30
2.4
2.0
—
—
—
0
0
48
368
1.47
1.28
5.1
3.3
0.00
0.00
estimate
-0.00
15
108
22
143
1.64
1.21
14.5
8.3
0.41
0.96
mmol/l
0.34
17
119
32
228
1.53
1.20
1.7
1.3
9.52
30.67
iu/ml
—
9
71
20
127
1.67
1.19
1.3
1.3
—
—
—
0
0
22
144
1.63
1.18
4.4
5.1
7.37
7.39
ph
0.49
17
85
46
355
1.44
1.17
5.0
4.1
0.00
0.00
estimate
-0.00
19
126
60
492
1.39
1.08
5.6
3.8
0.00
0.01
estimate
0.50
15
115
33
243
1.47
1.06
1.6
1.8
225000395.68
470.02
pmol/l
0.49
28
201
21
140
1.59
1.05
15.0
8.4
7.41
7.41
ph
0.01
15
86
76
652
1.37
1.02
10.7
6.6
2.39
1.87
e9/l
0.44
64
572
29
211
1.47
0.99
1.6
1.3
1.05
9.11
u/ml
1.67
13
75
26
185
1.50
0.99
1.8
1.9
—
—
—
0
0
75
646
1.35
0.96
10.7
6.6
0.04
0.04
e9/l
0.07
60
548
77
668
1.35
0.93
12.4
6.9
0.17
0.19
e9/l
0.32
63
580
74
641
1.33
0.89
10.8
6.6
0.59
0.57
e9/l
0.23
59
545
8
136
0.56
0.89
2.1
1.5
—
—
—
0
0
18
121
1.56
0.88
2.1
1.8
—
—
—
0
0
52
430
1.34
0.85
4.4
2.9
7.32
7.88
mmol/l
0.38
47
371
22
157
1.48
0.83
1.8
1.4
—
—
—
0
0
6
32
1.91
0.83
1.3
1.0
—
—
—
0
0
6
32
1.91
0.83
3.3
2.1
118.83
120.16
g/l
—
6
19
6
34
1.80
0.77
9.7
5.1
—
—
—
0
0
5
23
2.22
0.77
9.0
2.2
—
—
—
0
0
5
23
2.22
0.77
1.4
1.0
—
—
—
0
0
9
56
1.65
0.74
1.8
2.1
—
—
—
0
0
116
1088
1.42
0.74
6.2
5.6
1.72
1.95
mu/l
1.80
107
1006
5
25
2.04
0.73
1.2
1.0
—
—
—
0
0
7
41
1.74
0.71
2.7
2.3
—
—
—
0
0
7
41
1.74
0.71
1.7
1.4
—
—
—
0
0
5
28
1.81
0.67
1.4
1.9
51.80
59.04
%
—
5
28
47
397
1.28
0.64
4.4
3.1
24.59
41.25
mg/l
0.62
27
262
8
49
1.67
0.63
1.3
1.1
—
—
—
0
0
11
72
1.57
0.61
1.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
5.3
—
—
—
0
0
65
575
1.25
0.60
20.9
13.0
1.27
1.23
inr
0.18
51
474
11
73
1.55
0.58
3.5
3.3
—
—
—
0
0
34
279
1.29
0.58
4.9
4.2
1.01
1.02
kg/l
1.78
23
186
52
451
1.25
0.56
4.5
3.1
2.36
2.36
mmol/l
0.08
47
402
16
117
1.42
0.55
17.6
9.6
—
—
—
0
0
6
38
1.60
0.55
3.0
2.0
9.15
8.29
kpa
—
6
38
47
405
1.24
0.54
8.5
7.1
—
—
—
0
0
6
40
1.52
0.52
1.5
1.4
—
—
—
0
0
67
602
1.22
0.51
3.2
2.9
—
—
estimate
—
0
0
117
1116
1.32
0.50
5.1
4.4
1.32
1.27
mmol/l
0.31
104
1031
26
212
1.28
0.46
2.0
1.6
1072.95
1125.52
nmol/l
0.11
20
161
5
32
1.58
0.42
1.2
1.8
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
123
1188
1.33
0.41
26.6
16.6
21.59
23.89
mg/l
0.42
106
986
20
161
1.28
0.40
16.6
5.5
1.08
1.04
mmol/l
0.26
20
151
5
36
1.40
0.38
1.6
7.1
58.50
57.91
%
—
5
36
6
41
1.48
0.36
1.5
1.3
—
—
—
0
0
6
41
1.48
0.36
1.3
1.3
—
—
—
0
0
6
42
1.45
0.36
1.5
1.4
—
—
—
0
0
6
42
1.45
0.36
1.5
1.3
—
—
—
0
0
120
1160
1.26
0.36
6.3
5.1
5.94
5.92
mmol/l
0.06
109
1068
46
411
1.18
0.36
5.7
3.7
4.47
6.59
mg/mmol
0.28
27
264
11
83
1.35
0.33
1.4
1.1
101.15
327.95
u/ml
0.65
11
77
11
83
1.35
0.33
21.7
10.1
0.76
0.70
%
0.21
11
83
18
147
1.26
0.32
1.3
1.3
—
—
—
0
0
53
483
1.16
0.32
5.9
4.0
22.59
40.82
ng/l
1.03
41
341
128
1250
1.33
0.31
30.5
21.4
80.45
76.73
umol/l
0.47
128
1237
11
84
1.34
0.31
21.7
10.1
1.51
1.28
%
0.46
11
84
120
1164
1.24
0.31
5.9
5.1
1.41
1.49
mmol/l
1.44
108
1080
9
116
0.76
0.29
1.2
1.2
—
—
—
0
0
25
217
1.19
0.27
3.5
3.1
0.75
0.75
ug/l
0.01
17
125
38
342
1.15
0.27
10.4
4.7
—
—
—
0
0
27
237
1.17
0.25
4.3
3.8
397.67
178.95
ng/l
0.32
21
178
10
78
1.30
0.25
2.0
4.8
0.75
0.64
%
—
10
78
120
1170
1.20
0.24
6.2
5.2
4.49
4.62
mmol/l
0.83
109
1091
5
37
1.36
0.24
2.4
2.0
25.96
24.95
mmol/l
—
5
37
22
191
1.18
0.23
16.0
8.2
106.41
103.86
mmol/l
1.72
22
191
5
38
1.33
0.23
1.2
1.2
—
—
—
0
0
11
88
1.27
0.23
1.9
2.3
—
—
—
0
0
42
456
0.89
0.22
4.5
3.1
—
—
—
0
0
28
312
0.87
0.22
1.4
1.3
1.81
1.63
u/ml
—
9
81
11
89
1.26
0.21
7.2
3.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
2.05
—
0
11
0
11
0.00
0.21
0.0
6.0
—
601.00
—
0
6
10
80
1.27
0.21
2.0
4.8
1.30
1.21
%
—
10
80
10
121
0.81
0.18
1.7
1.3
—
—
—
0
0
121
1190
1.14
0.14
6.9
5.9
2.63
2.70
mmol/l
0.44
112
1109
10
86
1.18
0.11
1.2
1.3
—
—
—
0
0
13
115
1.14
0.11
1.4
1.8
—
—
—
0
0
5
46
1.09
0.09
1.6
1.1
—
—
—
0
0
19
175
1.10
0.09
1.5
1.3
—
—
—
0
0
6
58
1.04
0.08
1.0
1.3
—
—
—
0
0
6
58
1.04
0.08
1.8
1.3
—
—
—
0
0
27
286
0.93
0.08
1.7
1.5
2.30
2.60
g/l
0.24
20
165
10
112
0.88
0.07
3.1
2.6
4.29
7.99
ug/l
—
10
97
129
1280
1.12
0.06
37.9
25.3
254.96
251.33
e9/l
0.24
124
1264
16
150
1.08
0.04
2.9
1.7
—
—
—
0
0
42
431
0.96
0.03
3.1
2.5
—
—
—
0
0
29
280
1.05
0.03
12.1
4.5
—
—
—
0
0
22
229
0.95
0.03
3.9
2.0
—
—
—
0
0
10
94
1.07
0.01
1.7
1.6
—
—
—
0
0
14
141
0.99
0.00
2.9
1.6
—
—
—
0
0
19
193
0.98
0.00
2.9
1.7
—
—
—
0
0
36
363
0.99
0.00
1.5
1.5
—
—
—
0
0
123
1228
1.01
0.00
22.6
14.3
—
—
—
0
0
15
145
1.04
0.00
1.5
1.7
—
—
—
0
0
5
59
0.84
0.00
3.2
3.9
14.80
2936.77
u/ml
—
5
52
0
6
0.00
-0.00
0.0
2.3
—
70.33
—
0
6
0
6
0.00
-0.00
0.0
2.0
—
0.59
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
33.34
—
0
7
129
1281
1.11
-0.00
37.8
25.3
4.45
4.46
e12/l
0.11
124
1260
8
85
0.94
-0.00
3.9
3.5
346.63
157.79
ng/l
—
8
75
0
5
0.00
-0.00
0.0
3.4
—
21.50
—
0
5
0
7
0.00
-0.00
0.0
2.0
—
132.00
—
0
7
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
8
86
0.93
-0.00
5.1
3.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
1768.13
—
0
8
8
81
0.99
-0.00
6.3
2.5
7.43
7.42
ph
—
8
69
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
52.83
—
0
6
0
8
0.00
-0.00
0.0
1.5
—
0.00
—
0
8
5
58
0.86
-0.00
8.4
2.5
—
—
—
0
0
129
1281
1.11
-0.00
37.8
25.4
7.23
6.75
e9/l
0.44
124
1261
0
5
0.00
-0.00
0.0
1.6
—
1.79
—
0
5
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
62
0.97
-0.00
1.3
3.7
4.43
4.57
pmol/l
—
6
54
0
7
0.00
-0.00
0.0
1.0
—
177.63
—
0
7
0
5
0.00
-0.00
0.0
4.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_CHORSCAR and mortality.

Females

Parameter HR [95% CI] p-value
H7_CHORSCAR 1.083 [0.82, 1.43] 0.579
Birth year 0.995 [0.99, 1.0] 0.218

During the follow-up period (1.1.1998 — 31.12.2019), 63 out of 382 females with H7_CHORSCAR died.

Males

Parameter HR [95% CI] p-value
H7_CHORSCAR 0.918 [0.68, 1.23] 0.57
Birth year 0.992 [0.98, 1.0] 0.071

During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 360 males with H7_CHORSCAR died.

Mortality risk

Mortality risk for people of age

years, who have H7_CHORSCAR.

N-year risk Females Males
1 0.086% 0.217%
5 0.547% 1.201%
10 1.513% 2.911%
15 2.959% 6.027%
20 5.279% 10.064%

Relationships between endpoints

↥

Index endpoint: H7_CHORSCAR – Chorioretinal scars

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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