No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
96 |
4. Check minimum number of eventsNone |
96 |
5. Include endpointsNone |
96 |
6. Filter based on genotype QC (FinnGen only) |
88 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H31
- Name in latin
- Ablatio chorioideae
Similar endpoints
↥List of similar endpoints to
Choroidal detachment
based on the number of shared cases.
Similar with more cases:
- Other disorders of choroid
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 799 | 431 | 358 |
| Only index persons | 630 | 346 | 284 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 73.78 | 76.13 | 70.93 |
| Only index persons | 73.34 | 76.49 | 69.51 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 88 | 40 | 48 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 71.77 | 71.23 | 72.22 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 93
- Matched controls
- 930
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H31.4
ICD-10 Finland
Choroidal detachment
+∞
123.5
89
*
S01ED51
ATC
timolol, combinations; ophthalmic
32.0
66.9
60
50
114
Kela drug reimbursment
Glaucoma
18.9
47.9
55
66
Z96.1
ICD-10 Finland
Presence of intraocular lens
16.0
41.6
64
113
S01ED01
ATC
timolol; ophthalmic
19.0
35.0
32
25
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
18.9
34.0
31
24
S01EE01
ATC
latanoprost; ophthalmic
15.1
33.9
37
39
S01EA05
ATC
brimonidine; ophthalmic
41.7
30.7
38
15
S01EC01
ATC
acetazolamide; systemic
52.1
30.7
36
11
XCK00
NOMESCO Finland
Perimetry
13.6
26.4
29
30
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
79.6
22.1
24
*
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
27.0
21.8
30
16
XCW99
NOMESCO Finland
Other investigative procedure of eye
10.9
20.7
26
32
H33.0
ICD-10 Finland
Retinal detachment with retinal break
+∞
20.6
19
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
10.2
20.3
27
36
S01EX03, ,
ATC
32.2
20.0
26
11
S01EC04
ATC
brinzolamide; ophthalmic
22.8
20.0
29
18
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
9.5
18.5
78
330
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
+∞
18.3
17
*
S01EC03
ATC
dorzolamide; ophthalmic
33.3
18.0
23
9
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
7.1
17.6
69
269
WX140
NOMESCO Finland
Parabulbar anesthesy
26.4
17.6
24
12
XCK10
NOMESCO Finland
Photography of fundus of eye
7.2
14.3
25
45
S01EE03
ATC
bimatoprost; ophthalmic
38.1
13.1
16
5
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
149.3
12.8
13
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.4
12.6
32
82
CHD00
NOMESCO Finland
Laser trabeculoplasty
35.3
12.1
15
5
S01EE05
ATC
tafluprost; ophthalmic
12.6
11.8
21
21
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
+∞
11.7
11
*
CHC05
NOMESCO Finland
Iridotomy
29.4
11.6
15
6
S01EE04
ATC
travoprost; ophthalmic
29.4
11.6
15
6
S01EA03
ATC
apraclonidine; ophthalmic
32.5
11.1
14
5
S01EC54
ATC
brinzolamide, combinations; ophthalmic
32.5
11.1
14
5
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
68.0
10.9
12
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
15.7
10.7
17
13
CJB10
NOMESCO Finland
Laser discission of secondary cataract
5.3
10.1
24
57
CHD99
NOMESCO Finland
Other filtering operation
61.6
9.9
11
*
CHD35
NOMESCO Finland
Laser goniopuncture
110.8
9.6
10
*
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
41.1
9.2
11
*
XCH00
NOMESCO Finland
Eye pressure measurement
9.4
8.9
18
23
H25.1
ICD-10 Finland
Senile nuclear cataract
3.6
8.5
57
283
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
+∞
8.5
8
*
H57.1
ICD-10 Finland
Ocular pain
13.5
8.4
14
12
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
13.5
8.4
14
12
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.6
8.1
60
314
H26.4
ICD-10 Finland
After-cataract
4.4
8.1
24
68
CHD10
NOMESCO Finland
Trabeculectomy
+∞
7.4
7
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
7.4
7
*
S01BA07
ATC
fluorometholone; ophthalmic
32.8
7.3
9
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
43.3
6.9
8
*
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
19.7
6.4
9
5
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
28.8
6.3
8
*
S01EB01
ATC
pilocarpine; ophthalmic
28.8
6.3
8
*
3708
FHL
Trabeculectomy or equivalent
+∞
6.3
6
*
H35.36
ICD-10 Finland
Macular cyst
+∞
6.3
6
*
H40.0
ICD-10 Finland
Glaucoma suspect
4.3
6.3
18
49
H16.0
ICD-10 Finland
Corneal ulcer
9.6
6.3
12
14
S01BC05
ATC
ketorolac; ophthalmic
6.0
6.0
16
31
S01ED02
ATC
betaxolol; ophthalmic
16.4
6.0
9
6
S01BC03
ATC
diclofenac; ophthalmic
16.4
6.0
9
6
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
51
341
2.10
3.05
5.2
4.5
0.00
0.00
estimate
-0.00
14
73
51
346
2.05
2.89
5.1
4.6
0.00
21.65
estimate
0.49
14
75
51
348
2.03
2.82
5.2
4.7
0.00
0.00
estimate
-0.00
13
71
20
107
2.11
2.06
1.4
2.0
—
—
—
0
0
20
110
2.04
1.92
3.2
6.2
0.29
0.94
mmol/l
0.23
11
86
37
252
1.78
1.87
5.8
4.7
0.00
0.03
estimate
—
10
58
51
382
1.74
1.85
6.5
7.5
1.20
1.21
mmol/l
0.60
45
335
20
112
2.00
1.82
1.4
1.9
—
—
—
0
0
58
461
1.69
1.61
4.6
4.7
15.03
15.30
pmol/l
0.40
51
410
22
134
1.84
1.57
4.1
3.2
0.73
2.48
e6/l
—
10
64
28
187
1.71
1.47
5.5
4.1
0.00
0.04
estimate
—
9
56
32
227
1.62
1.33
4.2
3.4
0.07
0.44
e6/l
2.86
22
158
5
18
2.87
1.30
1.0
1.3
—
—
—
0
0
6
26
2.40
1.20
1.0
1.0
—
—
—
0
0
6
26
2.40
1.20
1.0
1.3
—
—
—
0
0
8
41
2.04
1.12
1.9
1.5
—
—
—
0
0
46
373
1.46
0.99
11.7
10.0
4.24
4.36
e9/l
0.15
41
324
21
144
1.59
0.98
1.6
2.1
—
—
—
0
0
38
298
1.47
0.97
2.7
2.5
—
—
estimate
—
0
0
10
55
1.92
0.96
1.3
1.9
—
—
—
0
0
66
579
1.48
0.91
4.9
5.3
4.49
4.35
mmol/l
0.31
58
527
26
191
1.50
0.90
6.6
4.8
0.00
0.00
estimate
—
10
63
11
66
1.76
0.83
2.0
1.6
—
—
—
0
0
21
152
1.49
0.78
1.8
1.8
1092.93
1128.83
nmol/l
0.05
12
115
22
161
1.48
0.78
3.3
3.0
2.46
2.47
mmol/l
0.16
17
143
14
94
1.58
0.72
1.1
1.3
18.05
10.82
u/ml
—
6
26
20
146
1.47
0.71
4.2
3.0
1.30
0.92
e6/l
—
8
75
22
164
1.45
0.71
2.1
1.9
506.07
458.89
pmol/l
0.21
14
135
64
571
1.39
0.71
6.0
5.7
1.69
2.06
mu/l
2.36
58
505
64
574
1.37
0.66
4.6
5.3
1.41
1.43
mmol/l
0.15
57
518
17
122
1.48
0.66
5.2
6.1
104.18
103.82
mmol/l
0.12
17
122
19
140
1.45
0.65
1.2
1.2
0.77
4.11
u/ml
—
7
35
38
319
1.32
0.60
6.2
5.1
47.70
44.87
ng/l
0.07
28
251
26
206
1.36
0.60
4.3
2.5
57.12
77.22
u/l
0.44
26
193
64
579
1.34
0.59
7.9
7.2
41.91
41.00
mmol/mol
0.26
59
532
9
59
1.58
0.57
5.0
2.8
1.14
1.17
%
—
9
59
39
331
1.31
0.57
2.4
2.3
97.13
94.76
pmol/l
0.11
20
164
20
155
1.37
0.52
3.4
4.0
14.87
306.87
ng/l
1.14
15
139
65
595
1.31
0.51
6.3
6.3
2.68
2.48
mmol/l
0.68
58
542
23
187
1.31
0.45
5.4
4.6
20.88
23.54
%
0.45
12
97
67
622
1.28
0.43
25.2
19.7
26.95
27.10
mg/l
0.01
54
527
29
245
1.27
0.42
6.4
5.0
1.38
2.60
ug/l
1.35
24
212
5
33
1.54
0.42
5.6
3.2
28.00
61.40
u/ml
—
5
33
0
15
0.00
0.41
0.0
3.0
—
236.80
—
0
15
5
34
1.50
0.41
1.2
3.0
0.00
0.38
g/l
—
5
29
29
251
1.23
0.34
3.3
3.8
16.83
8.00
mg/mmol
0.27
16
165
7
51
1.40
0.32
4.7
4.3
24.67
24.65
mmol/l
—
7
51
33
291
1.21
0.32
2.5
2.4
—
—
—
0
0
58
545
1.17
0.26
4.2
4.5
1.32
1.25
mmol/l
0.28
52
489
69
658
1.19
0.25
36.4
29.8
129.49
130.93
g/l
0.29
69
643
5
40
1.26
0.23
1.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
3.9
—
0.82
—
0
11
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
5.0
—
855.75
—
0
12
8
69
1.17
0.17
11.8
10.6
—
—
—
0
0
10
108
0.92
0.03
7.9
5.1
1.26
1.04
mmol/l
—
10
100
13
123
1.07
0.02
1.0
1.9
29.73
29.54
s
0.07
13
118
16
167
0.95
0.01
2.6
2.3
—
—
—
0
0
11
104
1.07
0.01
1.5
1.3
28.83
41.43
iu/ml
—
6
34
14
142
0.98
0.00
3.1
3.2
0.54
0.90
ug/l
—
7
97
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
91.80
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
15.95
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
59
1.02
-0.00
2.7
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
76
0.91
-0.00
7.4
3.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_CHORDETACH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHORDETACH | 0.994 [0.82, 1.21] | 0.953 |
| Birth year | 0.994 [0.99, 1.0] | 0.199 |
During the follow-up period (1.1.1998 — 31.12.2019), 151 out of 331 females with H7_CHORDETACH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHORDETACH | 0.9 [0.7, 1.15] | 0.399 |
| Birth year | 0.987 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 108 out of 260 males with H7_CHORDETACH died.
Mortality risk
Mortality risk for people of age
years, who have H7_CHORDETACH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.071% | 0.169% |
| 5 | 0.545% | 0.93% |
| 10 | 1.404% | 2.5% |
| 15 | 2.849% | 5.043% |
| 20 | 4.983% | 8.75% |
Relationships between endpoints
↥Index endpoint: H7_CHORDETACH – Choroidal detachment
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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