No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
165 |
4. Check minimum number of eventsNone |
165 |
5. Include endpointsNone |
165 |
6. Filter based on genotype QC (FinnGen only) |
145 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other specified and unspecified disorders of choroid
based on the number of shared cases.
Similar with more cases:
- Other disorders of choroid
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 751 | 407 | 340 |
| Only index persons | 694 | 385 | 309 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 59.10 | 60.28 | 57.74 |
| Only index persons | 58.78 | 59.62 | 57.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 145 | 84 | 61 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 59.58 | 60.01 | 58.99 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 151
- Matched controls
- 1510
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H31.9
ICD-10 Finland
Disorder of choroid, unspecified
+∞
93.8
80
*
H31.8
ICD-10 Finland
Other specified disorders of choroid
+∞
79.3
69
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
27.8
68.8
52
28
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
20.1
67.8
63
52
XCK10
NOMESCO Finland
Photography of fundus of eye
12.1
42.1
51
61
XCW99
NOMESCO Finland
Other investigative procedure of eye
14.0
41.6
44
43
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
41.1
24.4
30
9
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.6
22.4
58
151
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
134.6
22.2
23
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
15.4
15.9
26
20
XCD20
NOMESCO Finland
Photoangiography of eye
89.0
14.9
16
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
51.1
12.1
14
*
WX140
NOMESCO Finland
Parabulbar anesthesy
13.4
10.7
18
15
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
+∞
10.5
10
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
4.0
10.5
35
106
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
+∞
9.5
9
*
XCK00
NOMESCO Finland
Perimetry
5.3
9.4
20
42
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
95.1
8.5
9
*
H35.8
ICD-10 Finland
Other specified retinal disorders
+∞
8.4
8
*
H35.9
ICD-10 Finland
Retinal disorder, unspecified
+∞
8.4
8
*
CKE65
NOMESCO Finland
Removal of brachytherapeutic plate from eye
84.0
7.5
8
*
C69.30
ICD-10 Finland
Malignant tumor of the chorioidea without histology
84.0
7.5
8
*
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
84.0
7.5
8
*
CKE60
NOMESCO Finland
Brachytherapy of choroid and retina
84.0
7.5
8
*
C69.32
ICD-10 Finland
Malignant tumor of the chorioidea melanoma
+∞
7.3
7
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
7.8
6.9
15
21
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.5
6.8
62
329
H35.7
ICD-10 Finland
Separation of retinal layers
+∞
6.3
6
*
CK9G4
NOMESCO Finland
Iridocyanine green angiography (ICGA) of choroid and retina
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
36
159
2.66
5.61
5.5
5.3
233.42
243.46
u/l
0.23
36
151
103
779
2.01
3.87
10.9
10.5
4.18
4.03
e9/l
0.33
89
686
13
34
4.08
3.80
1.5
1.4
—
2.26
—
0
10
8
12
6.97
3.72
1.0
1.2
—
—
—
0
0
68
453
1.91
3.67
3.9
2.8
57.29
67.22
u/l
0.42
63
414
33
170
2.20
3.60
2.1
1.9
—
—
—
0
0
34
178
2.17
3.56
2.2
1.8
—
—
—
0
0
6
7
8.86
3.29
2.5
1.7
2085.83
761.14
u/ml
—
6
7
82
597
1.82
3.22
8.8
5.0
36.07
35.72
g/l
0.23
77
560
120
987
2.05
3.20
4.8
4.4
15.14
14.85
pmol/l
0.57
112
903
40
236
1.95
3.02
2.1
2.0
—
—
—
0
0
16
64
2.68
2.98
8.6
4.6
1.61
1.48
%
0.32
16
54
83
617
1.77
2.95
2.9
2.8
—
—
estimate
—
0
0
81
598
1.76
2.95
2.6
2.6
77.91
77.91
nmol/l
0.00
73
530
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
12
41
3.09
2.69
3.6
2.5
0.29
0.40
iu/ml
—
6
24
35
207
1.90
2.60
7.4
1.9
29.65
29.27
s
0.11
35
200
49
327
1.74
2.46
2.3
2.3
—
—
—
0
0
10
33
3.17
2.40
1.0
1.2
4.72
3.90
mmol/l
—
10
28
45
296
1.74
2.36
3.0
1.7
1.21
1.43
mg/l
0.24
37
239
6
15
4.12
2.06
1.8
1.3
—
—
—
0
0
6
15
4.12
2.06
1.0
1.0
—
—
—
0
0
6
15
4.12
2.06
1.0
1.0
—
—
—
0
0
118
1023
1.70
1.95
14.2
8.6
91.18
79.50
u/l
0.78
113
959
85
685
1.55
1.88
10.2
7.1
1.20
1.21
mmol/l
0.35
75
577
5
12
4.27
1.84
2.0
1.3
—
—
—
0
0
6
18
3.43
1.76
1.2
1.3
—
—
—
0
0
60
455
1.53
1.72
6.0
3.7
7.53
10.54
mg/mmol
0.41
45
276
132
1194
1.84
1.70
6.5
5.5
1.95
1.93
mu/l
0.06
124
1090
139
1280
2.08
1.67
5.0
5.2
1.44
1.47
mmol/l
0.29
128
1174
24
145
1.78
1.67
3.3
3.5
—
—
—
0
0
10
42
2.48
1.65
1.1
1.1
1.50
1.51
g/l
—
10
42
34
228
1.63
1.63
1.9
1.7
1055.23
1202.27
nmol/l
0.41
26
165
141
1307
2.19
1.63
24.9
16.5
23.45
23.37
mg/l
0.01
125
1072
5
14
3.65
1.63
1.4
1.2
—
—
—
0
0
139
1282
2.06
1.63
5.1
5.3
4.63
4.64
mmol/l
0.01
129
1181
8
33
2.50
1.56
1.5
1.2
—
—
—
0
0
32
214
1.63
1.55
4.3
7.4
104.72
104.02
mmol/l
0.52
32
214
47
346
1.52
1.52
2.5
2.1
2.81
3.30
mg/l
0.48
39
295
35
241
1.59
1.51
1.4
1.3
1.12
8.93
u/ml
2.08
14
92
10
45
2.31
1.50
1.3
1.2
0.95
0.85
g/l
—
10
45
10
45
2.31
1.50
1.2
2.6
0.91
2.70
ratio
—
5
22
6
22
2.80
1.45
3.2
2.0
12.83
10.13
mmol/l
—
6
22
135
1245
1.80
1.40
8.2
6.3
41.22
39.28
mmol/mol
1.45
126
1158
6
23
2.67
1.38
1.3
1.8
—
—
—
0
0
10
47
2.21
1.37
1.3
2.7
—
—
—
0
0
35
247
1.54
1.36
5.3
3.9
305.70
250.57
ng/l
0.09
27
186
140
1308
1.97
1.35
6.4
5.9
2.71
2.71
mmol/l
0.03
129
1200
8
35
2.36
1.29
1.1
1.3
—
—
—
0
0
8
36
2.29
1.26
1.1
1.3
—
—
—
0
0
8
38
2.17
1.20
1.3
1.4
—
—
—
0
0
6
26
2.36
1.20
1.2
1.2
—
—
—
0
0
6
26
2.36
1.20
1.2
1.2
—
—
—
0
0
60
487
1.39
1.12
4.7
3.3
—
—
—
0
0
72
603
1.37
1.11
2.6
2.1
102.63
97.29
pmol/l
0.34
45
285
5
21
2.43
1.10
1.2
1.1
—
—
—
0
0
14
82
1.78
1.09
2.8
3.8
24.48
24.15
mmol/l
0.12
14
82
66
553
1.34
0.99
4.6
4.1
22.41
36.10
ng/l
1.10
48
395
7
37
1.93
0.95
1.3
1.6
—
—
—
0
0
6
27
2.27
0.94
4.7
2.3
7.55
7.91
pmol/l
—
6
27
6
28
2.19
0.92
1.3
1.7
—
—
—
0
0
8
46
1.78
0.84
1.1
2.2
0.00
0.00
g/l
—
8
46
130
1223
1.45
0.81
4.3
4.5
1.34
1.30
mmol/l
0.23
118
1116
47
385
1.32
0.80
4.1
3.2
0.49
0.33
e6/l
0.18
35
277
100
906
1.31
0.80
4.6
3.4
53.96
48.33
u/l
0.31
95
859
15
100
1.56
0.76
2.3
3.0
39.67
65.13
ml/min/173m2
—
6
45
15
101
1.54
0.73
1.7
1.6
—
—
—
0
0
14
93
1.56
0.72
12.1
7.1
24.93
24.64
mmol/l
0.13
14
86
7
40
1.79
0.72
1.6
1.5
—
—
—
0
0
7
42
1.70
0.69
1.4
1.8
—
—
—
0
0
5
27
1.88
0.69
1.4
1.6
—
—
—
0
0
83
743
1.26
0.69
5.1
4.1
0.00
0.00
estimate
-0.00
18
151
83
744
1.26
0.67
5.0
4.0
0.00
10.02
estimate
0.50
20
162
33
263
1.33
0.67
1.5
1.3
75.21
32.02
iu/ml
—
9
78
12
79
1.56
0.65
12.9
7.6
15.22
15.95
%
0.59
12
73
81
728
1.24
0.63
5.0
4.0
0.00
0.00
estimate
-0.00
19
161
27
211
1.34
0.63
2.7
3.2
2.93
2.99
e6/l
0.01
12
97
5
30
1.69
0.62
1.2
1.1
0.95
1.09
u/ml
—
5
20
0
20
0.00
0.61
0.0
1.6
—
15.41
—
0
20
38
314
1.28
0.60
1.3
1.3
0.67
2.15
u/ml
1.26
11
89
11
159
0.67
0.58
9.1
8.0
—
—
—
0
0
8
121
0.64
0.57
1.4
2.0
—
—
—
0
0
6
36
1.69
0.57
1.3
1.3
—
—
—
0
0
132
1263
1.36
0.56
5.8
5.2
6.14
5.98
mmol/l
0.52
120
1154
6
38
1.60
0.55
1.2
2.0
—
—
—
0
0
6
40
1.52
0.52
1.2
1.8
—
—
—
0
0
6
40
1.52
0.52
1.2
1.6
—
—
—
0
0
29
236
1.28
0.52
3.0
3.1
0.73
0.89
e6/l
0.20
14
121
12
85
1.45
0.48
1.6
1.8
—
—
—
0
0
5
31
1.63
0.43
1.0
1.8
—
—
—
0
0
114
1084
1.21
0.42
31.9
20.6
13.78
13.70
%
0.27
114
1074
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
5
34
1.49
0.40
1.0
1.1
—
6.13
—
0
6
5
35
1.44
0.39
1.2
1.3
40.80
79.61
pmol/l
—
5
35
10
135
0.72
0.38
1.6
2.1
—
—
—
0
0
6
41
1.48
0.36
1.0
1.3
39.02
21.65
iu/l
—
6
35
35
306
1.19
0.34
5.5
4.3
1.02
1.02
kg/l
0.88
21
191
12
93
1.32
0.31
3.5
8.1
25.83
24.81
mmol/l
0.43
12
93
60
554
1.14
0.29
5.2
4.0
0.00
0.00
estimate
-0.00
18
135
46
417
1.15
0.29
2.1
1.7
17.73
21.59
nmol/l
1.38
41
337
32
282
1.17
0.28
1.6
1.8
435.96
50000461.69
pmol/l
0.50
27
234
8
63
1.28
0.28
1.7
2.1
—
—
—
0
0
5
73
0.67
0.26
2.2
1.3
—
—
—
0
0
45
410
1.14
0.26
4.0
3.4
0.00
0.00
estimate
-0.00
16
130
5
37
1.36
0.24
1.0
1.3
—
—
—
0
0
12
97
1.26
0.23
1.7
1.3
91.91
555.17
u/ml
0.93
12
87
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
4.29
—
0
13
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
17
146
1.19
0.20
10.2
8.7
116.24
119.71
g/l
0.42
17
140
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
6
52
1.16
0.19
1.7
2.0
—
—
—
0
0
11
91
1.23
0.18
2.4
2.7
0.53
0.64
%
0.81
11
91
45
420
1.10
0.17
5.6
4.1
0.00
0.00
estimate
-0.00
18
146
11
92
1.21
0.16
2.6
2.8
1.93
1.31
%
0.37
11
92
31
328
0.93
0.09
6.1
4.5
20.13
22.11
%
0.32
14
140
11
123
0.89
0.08
1.7
1.4
—
—
—
0
0
18
169
1.07
0.05
9.9
8.2
5.19
5.15
kpa
0.08
18
159
19
201
0.94
0.05
1.4
1.5
—
—
—
0
0
81
822
0.97
0.04
2.9
3.0
—
—
—
0
0
25
256
0.97
0.00
1.6
1.6
—
—
—
0
0
18
176
1.03
0.00
4.6
4.8
31.50
31.45
%
—
10
108
17
169
1.01
0.00
10.4
8.2
12.35
12.42
kpa
0.02
17
160
25
253
0.99
0.00
3.3
2.9
0.60
0.73
ug/l
0.44
17
153
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
9.13
—
0
8
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
5
49
1.02
-0.00
1.6
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
70.70
—
0
9
0
9
0.00
-0.00
0.0
5.3
—
0.44
—
0
9
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
6
65
0.92
-0.00
1.2
1.0
—
—
—
0
0
6
64
0.93
-0.00
1.3
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
8.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_CHORNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHORNAS | 1.072 [0.76, 1.51] | 0.693 |
| Birth year | 0.995 [0.99, 1.0] | 0.211 |
During the follow-up period (1.1.1998 — 31.12.2019), 62 out of 338 females with H7_CHORNAS died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have H7_CHORNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.093% | No data |
| 5 | 0.555% | No data |
| 10 | 1.562% | No data |
| 15 | 3.141% | No data |
| 20 | 5.669% | No data |
Relationships between endpoints
↥Index endpoint: H7_CHORNAS – Other specified and unspecified disorders of choroid
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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