No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
135 |
4. Check minimum number of eventsNone |
135 |
5. Include endpointsNone |
135 |
6. Filter based on genotype QC (FinnGen only) |
119 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H31
- Name in latin
- Haemorrhagia chorioideae
Similar endpoints
↥List of similar endpoints to
Choroidal haemorrhage and rupture
based on the number of shared cases.
Similar with more cases:
- Other disorders of choroid
- Disorders of choroid and retina
- Bleeding
- Diseases of the eye and adnexa
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1087 | 570 | 511 |
| Only index persons | 959 | 503 | 456 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 70.48 | 75.66 | 64.66 |
| Only index persons | 69.40 | 75.24 | 62.96 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 119 | 50 | 69 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 66.43 | 64.77 | 67.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 123
- Matched controls
- 1230
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H31.3
ICD-10 Finland
Choroidal haemorrhage and rupture
+∞
159.6
116
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
12.5
32.1
37
41
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
109.0
24.7
26
*
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
155.3
24.6
25
*
XCK10
NOMESCO Finland
Photography of fundus of eye
7.8
21.5
36
62
Z96.1
ICD-10 Finland
Presence of intraocular lens
6.2
21.3
51
126
WX140
NOMESCO Finland
Parabulbar anesthesy
24.3
21.3
30
16
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
83.5
19.4
21
*
S01ED51
ATC
timolol, combinations; ophthalmic
7.7
19.4
32
54
H43.1
ICD-10 Finland
Vitreous haemorrhage
53.0
19.0
22
5
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
8.1
18.4
28
43
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
+∞
18.2
17
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
+∞
17.1
16
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.3
16.8
45
120
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
4.7
15.9
78
332
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
31.7
14.8
19
7
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
26.2
14.8
20
9
CKD40
NOMESCO Finland
Endophotocoagulation of retina
+∞
12.7
12
*
H33.3
ICD-10 Finland
Retinal breaks without detachment
+∞
12.7
12
*
114
Kela drug reimbursment
Glaucoma
5.0
12.4
32
81
H35.6
ICD-10 Finland
Retinal haemorrhage
+∞
11.6
11
*
S01EC01
ATC
acetazolamide; systemic
13.8
11.3
19
16
CKC10
NOMESCO Finland
Local photocoagulation of retina
119.8
10.6
11
*
S01EE01
ATC
latanoprost; ophthalmic
5.1
10.1
24
56
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
+∞
9.5
9
*
S01EA05
ATC
brimonidine; ophthalmic
10.3
9.4
18
20
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.2
9.1
72
377
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
8.4
8.9
19
26
XCD20
NOMESCO Finland
Photoangiography of eye
53.9
8.8
10
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.3
8.5
25
69
CKC12
NOMESCO Finland
Photocoagulation of retina
96.4
8.5
9
*
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
96.4
8.5
9
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
+∞
8.4
8
*
H26.4
ICD-10 Finland
After-cataract
4.1
8.4
26
75
H40.9
ICD-10 Finland
Glaucoma, unspecified
18.8
8.3
12
7
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
85.0
7.5
8
*
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
+∞
7.4
7
*
3636A
ICD-9 Finland
Chorioretinal inflammations and scars and other disorders of choroid, Choroidal haemorrhage and rupture
+∞
7.4
7
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
+∞
7.4
7
*
WX142
NOMESCO Finland
Sub-tenon anesthesy
+∞
7.4
7
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
11.0
7.2
13
13
S01EC03
ATC
dorzolamide; ophthalmic
15.4
6.5
10
7
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
73.5
6.5
7
*
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
28.3
6.3
8
*
CKD15
NOMESCO Finland
Injection of vitreous substitute
+∞
6.3
6
*
S01EC04
ATC
brinzolamide; ophthalmic
6.2
6.2
16
29
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
47
264
2.26
4.38
2.6
2.1
3.09
3.25
mg/l
0.24
39
228
61
402
2.03
3.61
4.1
3.0
130.00
148.02
ug/l
0.21
54
367
53
333
2.04
3.57
4.8
3.8
8.24
7.70
mg/mmol
0.05
33
229
72
513
1.97
3.33
7.5
7.8
1.20
1.21
mmol/l
0.35
59
433
114
990
3.07
3.27
32.2
28.6
129.97
133.30
g/l
1.52
114
977
114
990
3.07
3.27
32.2
28.8
38.23
39.78
%
1.45
114
978
114
990
3.07
3.27
31.7
28.3
91.51
91.52
fl
0.01
114
979
74
536
1.96
3.22
4.9
4.2
0.00
0.00
estimate
-0.00
18
114
105
866
2.45
3.19
7.6
6.8
42.25
40.30
mmol/mol
1.15
98
792
112
954
2.95
3.13
26.4
22.8
139.72
139.46
mmol/l
0.46
112
936
112
955
2.93
3.11
26.8
22.9
4.00
4.00
mmol/l
0.04
112
936
73
531
1.92
3.09
4.8
4.2
0.00
13.20
estimate
0.50
21
123
113
972
3.00
3.00
29.6
25.0
85.38
83.67
umol/l
0.21
113
960
72
525
1.90
2.99
4.8
4.2
0.00
0.00
estimate
-0.00
21
120
87
685
1.92
2.74
3.9
4.1
15.03
15.20
pmol/l
0.27
79
612
105
893
2.20
2.51
5.5
5.2
4.41
4.48
mmol/l
0.26
96
805
107
919
2.26
2.46
20.9
19.4
23.32
25.65
mg/l
0.39
88
780
104
888
2.11
2.36
5.3
5.2
1.42
1.44
mmol/l
0.12
95
801
22
115
2.11
2.34
3.5
3.3
—
—
—
0
0
100
844
1.99
2.31
4.9
5.1
2.08
2.02
mu/l
0.18
94
750
103
883
2.02
2.21
19.7
18.1
71.78
75.24
ml/min/173m2
0.80
98
827
100
849
1.95
2.20
4.7
4.4
1.27
1.27
mmol/l
0.01
90
759
16
76
2.27
2.13
3.1
3.1
64.78
62.09
ml/min/173m2
—
9
35
71
553
1.67
2.05
8.3
10.0
4.42
4.32
e9/l
0.12
66
492
103
893
1.94
1.99
5.6
5.5
6.31
6.03
mmol/l
1.27
97
801
59
444
1.63
1.91
2.5
3.1
—
—
estimate
—
0
0
105
920
1.97
1.90
6.3
5.9
2.47
2.61
mmol/l
0.79
97
832
88
733
1.70
1.89
8.5
8.6
89.88
83.17
u/l
0.16
81
686
15
75
2.14
1.78
1.4
1.5
—
—
—
0
0
55
415
1.59
1.71
5.5
4.4
0.13
0.04
estimate
0.28
16
98
57
440
1.55
1.58
5.6
4.9
32.72
55.99
ng/l
1.11
44
335
41
298
1.56
1.46
3.7
3.3
0.19
0.35
e6/l
0.93
35
230
43
322
1.52
1.33
5.8
4.1
0.00
0.00
estimate
-0.00
19
104
25
167
1.62
1.25
4.4
6.9
103.64
103.56
mmol/l
0.02
25
167
27
186
1.58
1.19
2.3
2.2
—
—
—
0
0
49
384
1.46
1.19
3.8
3.6
2506.73
1799.15
ng/l
0.71
42
314
8
39
2.12
1.17
1.1
1.3
—
—
—
0
0
13
73
1.87
1.16
1.9
3.0
0.91
1.31
%
1.37
13
73
82
711
1.46
1.15
4.7
4.4
14.49
13.91
mm/h
0.10
76
652
31
223
1.52
1.14
5.5
5.1
1.02
1.02
kg/l
0.09
20
147
7
33
2.19
1.07
1.7
1.7
—
—
—
0
0
32
236
1.48
1.04
2.2
1.9
432.09
446.11
pmol/l
0.09
22
196
68
579
1.39
1.00
3.1
3.3
48.79
58.88
u/l
0.52
61
535
0
29
0.00
0.99
0.0
1.5
—
—
—
0
0
39
305
1.41
0.93
1.5
1.8
17.03
19.80
nmol/l
0.60
30
245
12
71
1.76
0.92
2.0
3.0
0.62
0.67
%
0.22
12
71
8
44
1.87
0.88
1.0
1.0
—
—
—
0
0
32
245
1.41
0.86
1.9
2.6
—
—
—
0
0
58
492
1.34
0.83
3.0
2.9
—
—
—
0
0
50
418
1.33
0.78
6.2
5.5
4.02
2.64
ug/l
0.51
44
358
10
60
1.73
0.74
4.9
8.2
27.10
24.06
mmol/l
—
10
60
7
39
1.84
0.74
2.1
2.1
—
—
—
0
0
30
234
1.37
0.72
3.3
3.2
1.82
0.82
ug/l
0.60
17
157
39
320
1.32
0.68
5.6
4.9
22.83
22.38
%
0.06
20
177
28
219
1.36
0.66
1.5
1.8
0.70
1.68
mg/l
1.95
20
178
54
465
1.29
0.66
4.9
4.9
34.03
34.72
g/l
0.31
46
437
5
30
1.69
0.62
1.2
1.5
—
—
—
0
0
5
30
1.69
0.62
1.2
1.5
—
—
—
0
0
0
20
0.00
0.61
0.0
1.3
—
2.10
—
0
6
13
89
1.52
0.61
6.2
7.2
17.73
10.62
mmol/l
1.67
13
82
20
150
1.40
0.60
4.5
6.9
0.92
0.74
mmol/l
0.08
13
117
0
21
0.00
0.60
0.0
1.4
—
—
—
0
0
36
302
1.27
0.53
4.6
3.8
0.06
0.02
estimate
0.25
17
93
51
447
1.24
0.52
2.1
2.2
94.65
94.06
pmol/l
0.03
29
233
26
213
1.28
0.46
2.0
1.7
1021.23
1238.36
nmol/l
0.68
20
161
18
140
1.33
0.45
2.1
2.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.9
—
—
—
0
0
0
16
0.00
0.41
0.0
1.9
—
—
—
0
0
0
16
0.00
0.41
0.0
1.9
—
—
—
0
0
8
60
1.36
0.41
1.1
1.7
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
21
173
1.26
0.36
2.2
3.1
1.15
0.84
e6/l
0.48
16
100
7
55
1.29
0.30
1.7
1.9
13.62
1.19
ug/l
—
7
50
17
144
1.21
0.23
1.1
1.3
21.65
9.78
u/ml
0.46
11
59
5
39
1.29
0.23
1.4
2.1
32.28
73.26
u/ml
—
5
39
16
135
1.21
0.23
2.2
2.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
305.51
—
0
13
0
14
0.00
0.20
0.0
1.8
—
—
—
0
0
0
14
0.00
0.20
0.0
1.8
—
—
—
0
0
15
129
1.19
0.18
1.7
1.5
—
—
—
0
0
37
347
1.09
0.13
2.0
2.0
1.12
1.36
mmol/l
1.77
30
283
5
43
1.17
0.10
3.2
3.2
4.56
4.59
pmol/l
—
5
38
12
107
1.13
0.09
2.7
1.9
381.67
391.58
nmol/l
0.07
12
98
14
128
1.11
0.07
8.8
8.9
—
—
—
0
0
8
91
0.87
0.07
1.5
1.5
—
—
—
0
0
21
201
1.05
0.03
1.5
1.2
0.76
2.67
u/ml
0.85
11
52
16
153
1.05
0.01
2.6
3.2
2.33
2.31
e6/l
0.00
11
80
0
8
0.00
0.00
0.0
3.8
—
238.13
—
0
8
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
60.32
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
0.00
0.0
3.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.7
—
0.78
—
0
9
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1757.60
—
0
5
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.3
—
9.83
—
0
6
0
6
0.00
-0.00
0.0
1.7
—
61.95
—
0
6
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.3
—
4.43
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_CHORHAEMORRHAGE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHORHAEMORRHAGE | 1.035 [0.83, 1.28] | 0.757 |
| Birth year | 0.994 [0.99, 1.0] | 0.161 |
During the follow-up period (1.1.1998 — 31.12.2019), 194 out of 506 females with H7_CHORHAEMORRHAGE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHORHAEMORRHAGE | 1.019 [0.79, 1.31] | 0.884 |
| Birth year | 0.992 [0.98, 1.0] | 0.089 |
During the follow-up period (1.1.1998 — 31.12.2019), 133 out of 419 males with H7_CHORHAEMORRHAGE died.
Mortality risk
Mortality risk for people of age
years, who have H7_CHORHAEMORRHAGE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.075% | 0.219% |
| 5 | 0.534% | 1.415% |
| 10 | 1.286% | 3.496% |
| 15 | 2.713% | 6.676% |
| 20 | 4.845% | 11.232% |
Relationships between endpoints
↥Index endpoint: H7_CHORHAEMORRHAGE – Choroidal haemorrhage and rupture
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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