pigmented villonodular synovitis: Pigmented villonodular synovitis (PVNS) is a rare benign proliferative disorder of the synovial membrane primarily affecting young adults (with a peak age of onset in the second to fourth decade of life) characterized by proliferative, locally invasive tumor-like lesions, usually involving a single joint, tendon sheath or bursae (most commonly the joints of the knee and hip and rarely others such as the ankle, shoulder and temporomandibular joints). It presents with pain and limitation of motion along with swelling, heat and tenderness over the involved joint, eventually leading to arthritic degeneration and significant locomotor deficit, if left untreated. PVNS can recur in patients even after treatment.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
335 |
4. Check minimum number of eventsNone |
335 |
5. Include endpointsNone |
335 |
6. Filter based on genotype QC (FinnGen only) |
307 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M12
- Name in latin
- Synovitis villonodularis [pigmentata]
Similar endpoints
↥List of similar endpoints to
Villonodular synovitis (pigmented)
based on the number of shared cases.
Similar with more cases:
- Other specific arthropathies, wide
- Polyarthropathies
- Finngen Rheumatological endpoints
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2060 | 1083 | 962 |
| Only index persons | 1901 | 1014 | 887 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 39.12 | 40.66 | 37.21 |
| Only index persons | 38.21 | 39.93 | 36.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 307 | 196 | 111 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.05 |
| Median age at first event (years) | 40.70 | 41.63 | 39.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 318
- Matched controls
- 3180
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M12.2
ICD-10 Finland
Villonodular synovitis (pigmented)
+∞
207.9
176
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
33.1
156.7
110
50
1220
FHL
Arthroscopy
81.2
155.0
84
14
7192F
ICD-9 Finland
Other and unspecified disorder of joint, Villonodular synovitis[SYNOVITIS VILLONODULARIS, POLVI]
+∞
141.5
125
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
22.7
114.4
92
56
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
61.6
99.0
56
11
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
36.0
91.0
59
20
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
39.8
89.2
56
17
A07EC01
ATC
sulfasalazine; oral, rectal
21.5
84.0
67
39
M13.9
ICD-10 Finland
Arthritis, unspecified
33.0
82.8
55
20
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
53.6
79.2
46
10
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
14.8
76.9
76
66
P01BA02
ATC
hydroxychloroquine; oral
26.4
76.3
55
25
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
36.0
76.1
49
16
L04AX03
ATC
methotrexate; systemic
15.7
72.4
68
54
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
15.3
57.7
54
42
M25.5
ICD-10 Finland
Pain in joint
5.8
53.1
155
451
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
78.4
52.3
58
9
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
51.5
48
*
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
76.7
51.2
57
9
WX320
NOMESCO Finland
Spinalanesthesy
6.1
49.2
114
268
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
254.3
44.1
44
*
NGR20
NOMESCO Finland
Intralesional or marginal excision of tumor of knee or lower leg
247.6
43.0
43
*
M19.0
ICD-10 Finland
Primary arthrosis of other joints
14.2
40.8
39
31
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
+∞
40.5
38
*
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
12.3
39.9
42
39
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
387.8
35.7
35
*
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
7.3
34.7
56
90
1222
FHL
Arthroscopy and synovial surgery
375.2
34.6
34
*
L01BA01
ATC
methotrexate; systemic
98.0
32.4
35
*
L88
ICPC
Rheumatoid/seropositive arthritis
53.7
32.4
38
8
L15
ICPC
Knee symptom/complaint
4.2
30.1
105
331
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
+∞
29.6
28
*
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
6.7
29.4
51
88
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
31.0
27.4
36
13
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
147.0
26.0
27
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
8.1
26.0
37
51
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
270.4
25.0
25
*
NGF10
NOMESCO Finland
Total synovectomy of knee, open
+∞
23.2
22
*
ZXD10
NOMESCO Finland
Scheduled procedure
3.2
22.5
150
699
9311
FHL
Knee cleansing surgery (synovectomy, debridement)
+∞
22.1
21
*
1221
FHL
Arthroscopy and meniscus surgery
82.5
21.0
23
*
1225
FHL
Arthroscopy and other therapeutic procedure
117.8
20.8
22
*
M01AX05
ATC
glucosamine; oral
4.4
20.1
56
146
M01AH01
ATC
celecoxib; oral
3.9
20.0
69
211
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
5.3
19.6
42
88
ZXA00
NOMESCO Finland
Right side
3.3
19.4
95
364
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
+∞
18.9
18
*
L04AA13
ATC
[U] leflunomide
106.4
18.8
20
*
M01AH05
ATC
etoricoxib; oral
3.0
18.2
222
1387
ZXA05
NOMESCO Finland
Left side
3.3
18.0
84
311
B01AB05
ATC
enoxaparin; parenteral
3.0
18.0
105
444
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
+∞
17.9
17
*
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
+∞
17.9
17
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.7
16.5
133
662
N02AX02
ATC
tramadol; systemic, rectal
2.7
16.3
149
789
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.6
15.8
149
798
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
28.0
15.8
21
8
7177A
ICD-9 Finland
Internal derangement of knee, Chondromalacia of patella
+∞
15.8
15
*
N02AJ06
ATC
codeine and paracetamol; systemic
2.6
15.7
154
841
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
4.7
15.5
38
89
M01AH02
ATC
rofecoxib; oral
3.8
15.4
52
155
M23.8
ICD-10 Finland
Other internal derangements of knee
17.6
15.0
23
14
NG1DG
NOMESCO Finland
Knee and lower leg very extensive MRI examination with high intensity magnet
84.1
14.7
16
*
TNG10
NOMESCO Finland
Puncture of knee
+∞
14.7
14
*
7170A
ICD-9 Finland
Internal derangement of knee, Old bucket handle tear of medial meniscus
+∞
14.7
14
*
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
28.7
14.4
19
7
L90
ICPC
Osteoarthrosis of knee
12.8
14.3
25
21
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
44.7
14.2
17
*
H02AB06
ATC
prednisolone; systemic
2.5
14.2
159
912
M09AX01
ATC
hyaluronic acid; parenteral
17.2
13.6
21
13
M01CB01
ATC
sodium aurothiomalate; parenteral
+∞
13.6
13
*
B01AF01
ATC
rivaroxaban; oral
4.1
13.6
40
108
WX111
NOMESCO Finland
Local infiltration anesthesia
146.0
13.6
14
*
M17.5
ICD-10 Finland
Other secondary gonarthrosis
146.0
13.6
14
*
M25.4
ICD-10 Finland
Effusion of joint
42.0
13.3
16
*
M16.1
ICD-10 Finland
Other primary coxarthrosis
13.8
13.1
22
17
M22.4
ICD-10 Finland
Chondromalacia patellae
25.5
12.6
17
7
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
+∞
12.6
12
*
A02BC02
ATC
pantoprazole; systemic
2.5
12.4
225
1565
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
28.0
12.2
16
6
D16.2
ICD-10 Finland
Benign neoplasm: Long bones of lower limb
48.6
12.0
14
*
D48.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Connective and other soft tissue
11.2
12.0
22
21
M79.6
ICD-10 Finland
Pain in limb
2.3
11.9
148
871
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
67.5
11.7
13
*
M01AE02
ATC
naproxen; oral, rectal
2.3
11.1
191
1274
S18
ICPC
Laceration/cut
2.2
10.9
154
946
Z3226
NOMESCO Finland
Physiotherapist
2.8
10.9
60
240
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
62.1
10.7
12
*
M01AC06
ATC
meloxicam; systemic, rectal
2.3
10.6
115
632
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
14.9
10.6
17
12
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
113.6
10.5
11
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
+∞
10.5
10
*
NG2AA
NOMESCO Finland
Patella X-ray examination
33.8
10.4
13
*
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.9
10.4
32
89
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
24.3
10.3
14
6
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
4.7
10.2
24
54
N03AX16
ATC
[U] pregabalin
2.5
10.1
76
355
M20.1
ICD-10 Finland
Hallux valgus (acquired)
12.8
10.0
17
14
J01AA02
ATC
doxycycline; systemic
2.5
9.9
255
1964
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.4
9.5
36
115
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
103.0
9.5
10
*
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
+∞
9.4
9
*
M19.2
ICD-10 Finland
Other secondary arthrosis
+∞
9.4
9
*
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
11.2
9.4
17
16
NF1AA
NOMESCO Finland
Hip X-ray examination
4.4
9.4
24
58
M02AA07
ATC
piroxicam; topical
2.2
9.3
113
646
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
4.7
9.2
22
50
ZXD20
NOMESCO Finland
Day surgery
2.9
9.1
45
169
M01AE11
ATC
tiaprofenic acid; oral, rectal
7.8
9.1
20
27
M01AE03
ATC
ketoprofen; systemic, rectal
2.1
9.0
114
659
R4110
NOMESCO Finland
Physiotherapy
2.2
9.0
90
475
TQW40
NOMESCO Finland
Remowal of suture of skin
3.7
8.7
29
85
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.8
8.6
27
76
M01AX17
ATC
nimesulide; oral
2.4
8.6
71
344
ND1CG
NOMESCO Finland
Wrist and hand extensive MRI examination with high intensity magnet
28.4
8.5
11
*
M24.2
ICD-10 Finland
Disorder of ligament
92.4
8.5
9
*
SPAT1202
SPAT
Intra-articular injection
13.2
8.5
14
11
X59
ICD-10 Finland
Exposure to unspecified factor
2.4
8.4
65
305
NG1BG, ,
SPAT
4.3
8.4
22
54
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
+∞
8.4
8
*
M25.0
ICD-10 Finland
Haemarthrosis
+∞
8.4
8
*
ZX140
NOMESCO Finland
Intra articular
+∞
8.4
8
*
72410
ICD-8 Finland
Internal derangement of joint, Other shoulder derangement
+∞
8.4
8
*
H02AB04
ATC
methylprednisolone; systemic
2.7
8.3
48
196
ZXE00
NOMESCO Finland
One hour or less
2.0
8.2
122
745
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
22.7
8.1
11
5
L04AB04
ATC
adalimumab; parenteral
13.5
7.9
13
10
M01AC01
ATC
piroxicam; systemic, rectal
2.7
7.9
45
182
N02BE01
ATC
paracetamol; systemic, rectal
2.8
7.9
285
2394
NG1AA, ,
SPAT
3.0
7.9
36
129
M01AB05
ATC
diclofenac; systemic, rectal
2.0
7.8
210
1567
M02.9
ICD-10 Finland
Reactive arthropathy, unspecified
46.1
7.7
9
*
L17
ICPC
Foot/toe symptom/complaint
2.1
7.7
92
517
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
12.3
7.6
13
11
M13.1
ICD-10 Finland
Monoarthritis, not elsewhere classified
81.9
7.4
8
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
7.4
143
949
L04AA17
ATC
[U] adalimumab
+∞
7.3
7
*
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
+∞
7.3
7
*
NK5AT
NOMESCO Finland
Joint injection with ultrasound guidance not elsewhere classified
+∞
7.3
7
*
7190F
ICD-9 Finland
Other and unspecified disorder of joint, Effusion of joint[HYDROPS (HYDRARTHRON), POLVI]
+∞
7.3
7
*
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
16.2
7.3
11
7
TQW40, ,
SPAT
2.8
7.3
38
147
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
5.9
7.2
19
34
NH1CG
NOMESCO Finland
Ankle and foot extensive MRI examination with high intensity magnet
20.6
7.2
10
5
N03AX12
ATC
[U] gabapentin; oral
2.5
7.2
47
204
WX002
NOMESCO Finland
Sedation and analgesia
2.4
7.0
54
252
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.2
6.9
68
352
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
17.2
6.8
10
6
L40.5
ICD-10 Finland
Arthropathic psoriasis
40.9
6.8
8
*
M01AH03
ATC
valdecoxib; oral
3.7
6.7
21
59
J01FF01
ATC
clindamycin; systemic
2.0
6.6
87
504
ND1AA
NOMESCO Finland
Wrist X-ray examination
3.1
6.5
28
97
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.4
6.5
46
207
1223
FHL
Arthroscopy and articular cartilage surgery
71.2
6.4
7
*
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
71.2
6.4
7
*
NG1DA
NOMESCO Finland
X-ray of knees
71.2
6.4
7
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.0
6.4
77
430
TNG11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in knee
+∞
6.3
6
*
7174A
ICD-9 Finland
Internal derangement of knee, Derangement of lateral meniscus
+∞
6.3
6
*
L04AA11
ATC
[U] etanercept
+∞
6.3
6
*
L04AK01
ATC
leflunomide; oral
+∞
6.3
6
*
NHR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of ankle or foot
+∞
6.3
6
*
M13.0
ICD-10 Finland
Polyarthritis, unspecified
+∞
6.3
6
*
NGE10
NOMESCO Finland
Incision or suture of capsule of knee joint
+∞
6.3
6
*
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
+∞
6.3
6
*
M07.3
ICD-10 Finland
Other psoriatic arthropathies
+∞
6.3
6
*
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
6.5
6.2
15
24
M16.9
ICD-10 Finland
Coxarthrosis, unspecified
6.0
6.2
16
28
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
3.7
6.1
19
53
S83.2
ICD-10 Finland
Tear of meniscus, current
3.6
6.1
20
58
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
39
14
31.52
29.70
1.7
1.0
—
—
—
0
0
98
357
3.52
22.01
1.3
1.1
4.92
1.49
u/ml
0.70
39
152
95
414
2.85
15.06
1.3
1.2
67.42
17.79
iu/ml
0.66
32
109
253
1874
2.71
11.98
6.3
3.2
10.71
10.46
mm/h
0.11
246
1747
208
1509
2.09
8.83
12.4
10.3
3.76
4.08
e9/l
1.40
180
1298
101
571
2.13
8.40
2.4
2.6
338.32
333.17
umol/l
0.22
96
514
247
1967
2.15
7.47
9.4
8.1
75.94
78.69
u/l
0.63
238
1865
154
1080
1.83
6.44
2.6
2.8
—
—
estimate
—
0
0
296
2626
2.84
5.66
17.2
13.2
18.82
24.81
mg/l
3.38
250
2039
91
563
1.86
5.55
2.3
2.4
—
—
—
0
0
24
85
2.97
5.38
1.9
2.0
—
—
—
0
0
20
65
3.22
5.16
1.5
1.4
0.00
0.05
iu/ml
—
5
10
158
1167
1.70
5.15
2.5
2.4
72.86
75.29
nmol/l
0.53
146
1074
13
23
5.85
5.12
2.0
1.2
—
—
—
0
0
289
2613
2.16
3.95
15.0
12.6
85.83
84.51
ml/min/173m2
0.59
270
2402
86
573
1.69
3.93
1.5
1.6
1.36
1.19
mg/l
0.18
63
439
64
393
1.79
3.89
1.8
2.0
—
—
—
0
0
20
81
2.57
3.54
2.0
1.8
—
—
—
0
0
151
1196
1.50
3.16
5.9
8.4
1.21
1.21
mmol/l
0.13
139
1043
137
1069
1.49
3.05
4.7
5.3
36.86
36.33
g/l
0.62
132
1019
11
31
3.64
3.02
1.6
1.4
—
—
—
0
0
11
31
3.64
3.02
1.6
1.4
—
—
—
0
0
11
31
3.64
3.02
1.6
1.4
—
—
—
0
0
212
1810
1.51
3.01
3.0
3.1
—
—
—
0
0
293
2714
2.01
2.92
16.7
15.6
139.88
139.74
mmol/l
0.46
288
2658
114
863
1.50
2.92
3.0
3.8
2.36
2.36
mmol/l
0.13
108
790
293
2721
1.98
2.79
16.8
15.7
3.95
3.95
mmol/l
0.02
286
2660
165
1354
1.45
2.76
4.1
3.4
89.81
0.00
estimate
0.48
16
260
164
1347
1.45
2.72
4.1
3.4
0.00
0.00
estimate
0.50
14
263
98
733
1.49
2.62
1.9
2.1
273.01
174.30
u/l
0.63
93
706
48
304
1.68
2.61
1.6
2.1
—
—
—
0
0
164
1361
1.42
2.50
4.1
3.4
0.00
0.04
estimate
1.20
15
253
7
16
4.45
2.49
1.1
1.1
—
—
—
0
0
6
12
5.07
2.41
2.7
2.1
—
—
—
0
0
9
27
3.40
2.41
1.7
1.5
—
—
—
0
0
9
27
3.40
2.41
1.7
1.5
—
—
—
0
0
9
27
3.40
2.41
1.7
1.5
—
—
—
0
0
87
646
1.48
2.39
2.9
3.4
644.12
1091.74
ng/l
2.28
76
541
16
71
2.32
2.38
1.1
1.3
—
—
—
0
0
16
71
2.32
2.38
1.5
1.3
—
—
—
0
0
133
1078
1.40
2.25
2.0
2.0
93.29
97.19
pmol/l
0.46
81
584
272
2507
1.59
2.22
5.7
5.1
1.80
1.91
mu/l
0.80
259
2340
131
1063
1.40
2.19
5.0
7.5
1.22
1.21
mmol/l
0.10
123
997
161
1356
1.38
2.13
6.3
7.5
9.59
11.62
umol/l
2.73
150
1304
63
451
1.49
2.06
3.0
3.9
32.95
379.73
ng/l
2.10
44
313
6
15
4.06
2.05
1.0
2.3
—
14.55
—
0
6
13
59
2.25
1.87
2.2
2.5
0.00
2.78
index
—
6
35
301
2873
1.89
1.82
21.4
16.9
72.89
74.80
umol/l
1.10
301
2841
18
95
1.95
1.79
1.2
1.6
—
—
—
0
0
49
343
1.51
1.78
1.8
2.2
—
—
—
0
0
56
405
1.46
1.74
3.0
2.5
0.92
1.00
e6/l
0.12
28
183
5
13
3.89
1.72
1.0
1.0
—
—
—
0
0
302
2891
1.89
1.72
16.3
10.3
26.46
26.52
u/l
0.03
297
2822
86
675
1.38
1.70
1.3
1.3
0.63
1.67
u/ml
1.00
16
195
273
2555
1.48
1.67
5.8
5.6
38.20
38.78
mmol/mol
0.57
264
2413
84
659
1.37
1.66
3.3
2.8
0.24
0.46
e6/l
0.84
62
450
69
524
1.40
1.65
1.7
1.5
—
—
—
0
0
13
64
2.08
1.56
1.8
1.2
—
—
—
0
0
9
37
2.47
1.49
1.1
1.2
—
—
—
0
0
5
16
3.16
1.44
2.8
3.6
1.60
1.38
%
—
5
16
165
1451
1.29
1.42
3.9
5.5
6.73
6.63
mmol/l
0.26
158
1368
10
47
2.16
1.35
1.1
1.1
—
—
—
0
0
0
39
0.00
1.34
0.0
2.0
—
12.93
—
0
39
19
114
1.71
1.31
1.2
1.3
280.58
231.09
miu/ml
0.21
12
53
5
18
2.80
1.29
1.2
1.1
29.00
35.56
u/l
—
5
18
5
18
2.80
1.29
1.2
1.1
99.20
103.38
u/l
—
5
18
5
115
0.43
1.28
1.2
1.5
417.80
335.66
mu/l
—
5
108
6
25
2.43
1.25
1.2
1.8
—
—
—
0
0
6
25
2.43
1.25
1.2
1.8
—
—
—
0
0
6
25
2.43
1.25
1.2
1.8
—
—
—
0
0
40
292
1.42
1.21
4.2
4.2
31.61
32.08
%
0.10
33
201
97
814
1.28
1.18
3.1
2.7
62.56
65.75
u/l
0.14
89
761
250
2345
1.31
1.17
22.9
17.2
331.66
332.99
g/l
1.71
250
2335
34
243
1.45
1.15
2.3
2.4
34.64
40.81
u/l
0.36
28
204
10
51
1.99
1.12
1.9
1.7
—
—
—
0
0
228
2119
1.27
1.11
4.8
4.3
14.44
14.62
pmol/l
0.54
220
1972
12
66
1.85
1.10
2.0
1.7
—
—
—
0
0
8
41
1.98
1.09
2.4
1.6
—
—
—
0
0
20
130
1.57
1.05
1.6
2.9
2.29
1.46
mmol/l
0.88
13
101
37
275
1.39
1.03
1.8
2.0
—
—
—
0
0
73
601
1.28
1.03
2.2
2.0
2.81
2.79
mg/l
0.03
63
520
11
61
1.83
0.99
1.3
1.3
—
19.22
—
0
11
13
77
1.72
0.96
1.3
1.2
—
—
—
0
0
10
55
1.84
0.93
1.2
1.3
—
57.81
—
0
7
47
371
1.31
0.91
2.1
1.9
1.47
1.36
%
0.48
39
332
48
383
1.30
0.86
2.9
2.6
5.88
2.47
e6/l
0.73
21
159
127
1133
1.20
0.84
2.0
1.9
1.37
1.37
mmol/l
0.00
122
956
305
2979
1.58
0.84
27.0
20.3
256.48
253.44
e9/l
0.35
300
2921
305
2980
1.57
0.83
26.9
20.2
91.13
90.72
fl
0.92
305
2952
305
2981
1.57
0.81
27.0
20.2
4.53
4.55
e12/l
0.26
299
2921
208
1946
1.20
0.80
3.8
3.3
55.60
45.15
u/l
0.74
196
1859
37
288
1.32
0.80
1.7
1.9
—
—
—
0
0
12
186
0.63
0.79
5.1
3.2
1.22
1.23
mmol/l
0.42
12
158
305
2983
1.55
0.78
27.2
20.4
136.26
136.84
g/l
0.32
305
2952
18
124
1.48
0.77
1.4
1.8
—
—
—
0
0
18
124
1.48
0.77
1.3
1.7
0.39
0.32
mg/l
—
8
54
16
108
1.51
0.75
1.3
1.5
—
—
—
0
0
15
218
0.67
0.74
3.1
2.9
—
—
—
0
0
7
38
1.86
0.74
1.4
1.9
—
—
—
0
0
7
38
1.86
0.74
1.1
1.5
—
—
—
0
0
90
787
1.20
0.73
3.7
4.1
14.58
8.38
mg/mmol
0.31
62
492
5
25
2.02
0.73
1.6
2.2
—
—
—
0
0
34
266
1.31
0.72
8.5
6.8
—
—
—
0
0
25
187
1.37
0.70
1.1
1.3
199.51
420.69
u/ml
0.71
25
172
71
610
1.21
0.69
4.8
3.3
1.02
1.02
kg/l
0.01
49
391
11
69
1.62
0.69
1.6
1.5
—
—
—
0
0
5
27
1.86
0.68
1.6
2.1
—
—
—
0
0
271
2617
1.24
0.66
5.1
4.5
5.89
5.87
mmol/l
0.10
257
2439
37
299
1.27
0.63
1.9
3.2
3.65
8.21
umol/l
2.44
31
270
65
562
1.20
0.60
4.1
3.8
22.95
21.88
%
0.17
27
248
0
22
0.00
0.59
0.0
1.5
—
7.85
—
0
22
42
348
1.24
0.59
2.5
1.7
888.22
1260.37
nmol/l
2.27
30
263
269
2605
1.21
0.57
4.4
4.0
1.40
1.28
mmol/l
1.97
256
2440
21
159
1.34
0.57
1.0
1.0
—
—
—
0
0
6
36
1.68
0.57
1.2
1.3
—
—
—
0
0
28
222
1.29
0.56
2.2
2.4
14.46
13.81
nmol/l
0.22
28
203
140
1296
1.14
0.55
2.8
2.9
94.52
116.50
ug/l
0.95
134
1227
6
38
1.59
0.54
1.2
1.1
—
—
—
0
0
11
74
1.50
0.54
1.3
1.5
388.50
301.01
ug/g
—
6
46
10
68
1.49
0.47
1.5
4.2
9.88
2.51
ratio
—
10
43
281
2745
1.20
0.45
5.3
4.7
4.73
4.77
mmol/l
0.30
272
2597
7
50
1.41
0.45
1.3
1.5
—
—
—
0
0
31
257
1.23
0.45
5.4
12.1
1.32
1.24
mmol/l
0.03
22
210
23
184
1.27
0.45
1.4
3.1
78.78
71.56
ml/min/173m2
—
9
85
49
426
1.18
0.44
2.8
2.7
0.53
0.75
ug/l
2.06
31
243
27
221
1.24
0.44
6.0
13.0
121.81
120.80
g/l
0.10
27
215
31
258
1.22
0.44
5.4
12.0
12.64
12.53
kpa
0.04
31
249
31
258
1.22
0.44
5.4
12.0
5.14
5.10
kpa
0.09
31
247
0
16
0.00
0.41
0.0
1.3
—
187.31
—
0
16
13
97
1.35
0.40
1.5
1.5
—
—
—
0
0
0
18
0.00
0.40
0.0
5.1
—
735.50
—
0
18
280
2741
1.18
0.39
5.2
4.6
1.41
1.47
mmol/l
1.78
269
2576
17
133
1.29
0.39
1.2
1.1
1.41
1.55
g/l
1.27
17
133
18
143
1.27
0.38
6.1
10.6
24.11
24.36
mmol/l
0.08
18
136
17
134
1.28
0.37
1.2
1.1
0.88
0.93
g/l
0.33
17
134
6
43
1.40
0.35
2.8
1.6
—
—
—
0
0
24
201
1.21
0.33
1.9
9.2
8.52
8.69
mmol/l
0.04
24
195
44
390
1.15
0.33
2.1
2.5
12.65
14.03
umol/l
0.63
44
363
7
52
1.35
0.31
2.6
1.6
—
—
—
0
0
8
66
1.22
0.27
1.3
1.3
54.63
283.73
pmol/l
—
8
66
8
66
1.22
0.27
1.1
1.2
—
—
—
0
0
282
2777
1.14
0.26
5.9
5.2
2.85
2.82
mmol/l
0.19
270
2617
8
67
1.20
0.26
1.3
1.7
1.14
0.82
nmol/l
—
8
55
19
161
1.19
0.24
3.8
3.8
4.54
4.47
pmol/l
0.08
14
149
5
42
1.19
0.21
1.8
3.3
5.16
7.79
pmol/l
—
5
42
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
10.31
—
0
13
0
13
0.00
0.21
0.0
1.9
—
57.20
—
0
13
47
509
0.91
0.20
1.9
1.7
473.48
51919178.66
pmol/l
0.96
42
443
6
51
1.18
0.19
1.0
1.3
—
—
—
0
0
6
51
1.18
0.19
1.0
1.3
—
—
—
0
0
38
414
0.91
0.19
1.9
2.0
3.14
3.53
ratio
1.75
29
334
10
81
1.24
0.19
2.8
2.7
25.11
25.28
mmol/l
—
10
81
99
948
1.06
0.17
3.3
3.4
18.84
79.72
ng/l
0.92
66
629
5
69
0.72
0.17
1.0
1.4
—
1.19
—
0
45
5
69
0.72
0.17
1.0
1.4
—
1.19
—
0
45
5
69
0.72
0.17
1.0
1.4
—
1.01
—
0
45
22
196
1.13
0.17
1.8
2.2
—
—
—
0
0
21
188
1.13
0.15
2.7
2.6
3.21
7.36
ug/l
1.97
21
167
36
334
1.09
0.14
4.5
8.4
104.08
104.23
mmol/l
0.06
36
334
10
86
1.17
0.11
1.4
2.1
104.10
89.34
%
—
10
80
14
125
1.13
0.10
7.4
17.4
16.61
15.75
%
0.62
14
118
74
766
0.96
0.10
3.1
2.8
0.00
0.01
estimate
0.74
14
215
72
743
0.96
0.08
5.0
3.4
0.00
0.00
estimate
0.50
15
253
18
195
0.92
0.08
1.5
1.4
—
—
—
0
0
7
65
1.08
0.08
4.3
2.9
—
—
—
0
0
8
76
1.05
0.07
1.1
1.1
—
—
—
0
0
8
77
1.04
0.07
1.1
1.1
—
—
—
0
0
18
167
1.08
0.07
1.7
2.2
—
—
—
0
0
32
305
1.05
0.06
1.8
1.7
3.21
3.56
mmol/l
1.48
23
225
108
1063
1.02
0.05
4.3
3.2
0.00
0.04
estimate
1.23
13
220
25
239
1.05
0.04
5.0
2.4
0.24
0.22
g/l
0.48
25
229
27
259
1.05
0.04
5.0
4.8
2.64
7.86
ug/l
1.82
19
220
19
180
1.06
0.04
1.9
1.6
—
—
—
0
0
47
480
0.98
0.02
1.6
1.5
—
—
—
0
0
15
142
1.06
0.02
1.6
2.8
1.04
1.24
%
0.77
15
142
14
148
0.94
0.02
1.6
1.3
—
—
—
0
0
12
118
1.02
0.00
1.5
1.7
—
—
—
0
0
12
122
0.98
0.00
2.0
3.3
25.60
24.93
mmol/l
0.44
12
117
15
149
1.01
0.00
7.6
13.0
1.40
1.43
%
0.03
15
149
10
103
0.97
0.00
2.8
1.7
4.89
2.16
ug/l
—
10
92
13
135
0.96
0.00
1.3
1.4
—
—
—
0
0
14
144
0.97
0.00
5.6
11.0
25.38
25.03
mmol/l
0.19
14
144
15
146
1.03
0.00
7.6
13.1
0.72
0.65
%
0.26
15
146
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
2.8
—
154.00
—
0
9
0
5
0.00
-0.00
0.0
2.8
—
30.40
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
6.50
—
0
5
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
10
100
1.00
-0.00
4.3
10.0
1.54
1.65
%
—
10
90
0
6
0.00
-0.00
0.0
1.0
—
98.50
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.21
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
98.67
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
58.80
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
7.81
—
0
7
0
5
0.00
-0.00
0.0
3.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_VILLONODULAR and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have M13_VILLONODULAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: M13_VILLONODULAR – Villonodular synovitis (pigmented)
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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