sebaceous gland disease: A skin disease that is located_in the sebaceous gland.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
647 |
4. Check minimum number of eventsNone |
647 |
5. Include endpointsNone |
647 |
6. Filter based on genotype QC (FinnGen only) |
575 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified acne
based on the number of shared cases.
Similar with more cases:
- Acne
- Acne, including avohilmo
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4278 | 2091 | 2170 |
| Only index persons | 4081 | 2024 | 2057 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.06 |
| Only index persons | 0.08 | 0.07 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 23.04 | 26.01 | 20.09 |
| Only index persons | 22.92 | 25.91 | 19.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 575 | 355 | 220 |
| Unadjusted period prevalence (%) | 0.12 | 0.13 | 0.10 |
| Median age at first event (years) | 28.16 | 29.45 | 26.07 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 601
- Matched controls
- 6010
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L70.9
ICD-10 Finland
Acne, unspecified
283.8
307.7
326
25
L70.8
ICD-10 Finland
Other acne
709.7
269.6
247
6
D10BA01
ATC
isotretinoin; oral
14.3
230.3
277
339
L70.0
ICD-10 Finland
Acne vulgaris
22.0
225.5
186
120
J01AA04
ATC
lymecycline; systemic
7.1
117.8
248
543
J01AA07
ATC
tetracycline; systemic
6.5
106.4
243
569
L73.2
ICD-10 Finland
Hidradenitis suppurativa
33.9
72.8
47
15
D10AX03
ATC
azelaic acid; topical
5.3
65.0
159
380
G03HB01
ATC
cyproterone and estrogen; oral
4.4
49.1
150
422
L70
ICD-10 Finland
Acne
6.5
43.7
76
130
L71.9
ICD-10 Finland
Rosacea, unspecified
10.9
38.2
42
41
D06BX01
ATC
metronidazole; topical
4.4
36.4
102
265
L70.1
ICD-10 Finland
Acne conglobata
123.7
33.0
35
*
E0000UV, ,
ATC
2.7
32.3
336
1898
E0001A1, ,
ATC
6.8
32.1
52
82
70612
ICD-8 Finland
Diseases of sebaceous glands, Acne alia sive NUD
+∞
30.5
29
*
S96
ICPC
Acne
6.4
27.7
48
81
L71
ICD-10 Finland
Rosacea
8.2
25.8
35
45
XQ848
NOMESCO Finland
Dermatological photography
7.8
25.3
36
49
L73.8
ICD-10 Finland
Other specified follicular disorders
25.7
24.6
34
14
L72.1
ICD-10 Finland
Trichilemmal cyst
5.0
23.8
54
117
TQW80
NOMESCO Finland
Local dermatologic skincare
7.6
23.5
34
47
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.2
21.8
62
161
L71.8
ICD-10 Finland
Other rosacea
20.4
21.0
31
16
L04AX01
ATC
azathioprine; systemic
4.6
20.8
51
118
J01FF01
ATC
clindamycin; systemic
2.4
19.8
174
866
H02AB06
ATC
prednisolone; systemic
2.2
19.4
281
1718
D10AF01
ATC
clindamycin; topical
4.1
19.4
56
147
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.4
18.2
167
842
E000001, ,
ATC
2.4
18.2
166
835
L04AA06
ATC
mycophenolic acid; systemic
7.2
17.9
27
39
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
8.0
17.5
24
31
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
4.3
17.1
45
110
UJF32
NOMESCO Finland
Coloscopy
2.4
15.5
128
612
C03DA01
ATC
spironolactone; oral
3.3
14.5
58
190
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
14.3
234
1457
L08.8
ICD-10 Finland
Other specified local infections of skin and subcutaneous tissue
4.5
14.2
35
81
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
14.1
143
744
127
Kela drug reimbursment
Transplant complication
6.5
13.4
22
35
S10
ICPC
Boil/carbuncle
3.2
13.1
54
180
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
12.8
137
725
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
12.1
89
402
L04AD01
ATC
ciclosporin; systemic
5.8
12.0
22
39
SPAT1301
SPAT
No procedures
1.9
11.9
194
1191
D07AC01
ATC
betamethasone; topical
1.9
11.8
210
1326
WZC00
NOMESCO Finland
Treatment plan or consultation
1.8
11.8
251
1679
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.3
11.4
99
481
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
3.2
11.1
45
148
D07AD01
ATC
clobetasol; topical
2.3
11.1
92
437
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
9.5
11.1
22
24
L71.0
ICD-10 Finland
Perioral dermatitis
4.6
11.1
26
58
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.5
11.0
38
113
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
9.8
10.8
21
22
A11CC03
ATC
alfacalcidol; systemic
5.7
10.8
20
36
A02BC02
ATC
pantoprazole; systemic
1.8
10.7
347
2608
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.5
10.6
74
325
J01DB01
ATC
cefalexin; oral
2.2
10.6
511
4347
SPAT1249
SPAT
Treatment-related counselling outside office
1.8
10.6
258
1782
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
16.4
10.4
16
10
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
10.1
194
1244
TK800
NOMESCO Finland
Hemodialysis
8.7
10.1
21
25
H02AB04
ATC
methylprednisolone; systemic
2.4
10.0
76
348
J01AA02
ATC
doxycycline; systemic
1.8
9.9
391
3078
V03AE01
ATC
polystyrene sulfonate; oral
20.4
9.8
14
7
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.0
9.7
121
673
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
15.3
9.6
15
10
L30.3
ICD-10 Finland
Infective dermatitis
3.9
9.4
28
75
N02AX02
ATC
tramadol; systemic, rectal
1.8
9.4
206
1369
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
9.4
117
650
Z94.0
ICD-10 Finland
Kidney transplant status
9.7
9.3
18
19
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.5
9.1
58
244
SPAT1255
SPAT
Intravenous administration of medicine
3.2
9.1
37
122
N18.8
ICD-10 Finland
Other chronic renal failure
9.2
9.1
18
20
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
37.3
9.0
11
*
A02BC01
ATC
omeprazole; systemic
1.9
8.9
140
839
S29
ICPC
Skin symptom/complaint other
1.9
8.9
131
769
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.7
8.9
208
1404
N03AX16
ATC
[U] pregabalin
2.0
8.8
108
596
Z49.1
ICD-10 Finland
Extracorporeal dialysis
14.3
8.7
14
10
J01CF05
ATC
flucloxacillin; systemic
2.5
8.7
56
237
L68.0
ICD-10 Finland
Hirsutism
50.7
8.7
10
*
J04BA02
ATC
dapsone; oral
16.6
8.6
13
8
A12AA04
ATC
calcium carbonate; oral
9.2
8.6
17
19
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.2
8.5
33
106
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
4.4
8.5
21
49
SPAT1310
SPAT
Counselling related to known health issue
1.7
8.4
208
1421
380
Kela drug reimbursment
Adalimumab (hidradenitis suppurativa)
+∞
8.3
8
*
7061X
ICD-9 Finland
Diseases of sebaceous glands, Other acne[ACNE ALIA DEFINITA]
+∞
8.3
8
*
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
7.2
8.3
19
27
UJF30
NOMESCO Finland
Ileoscopy through colon
2.4
8.3
60
268
QX3HE
NOMESCO Finland
Ultrsound examination of lesion close to skin
6.6
8.2
20
31
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
3.0
8.2
37
130
D07AC13
ATC
mometasone; topical
1.8
8.2
158
1006
N06AB03
ATC
fluoxetine; oral
2.2
8.2
76
378
137
Kela drug reimbursment
Uraemia requiring dialysis
10.2
8.1
15
15
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
3.1
8.1
34
115
TQW99
NOMESCO Finland
Other minor procedure on skin
3.6
8.1
26
74
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.6
8.1
26
74
SPAT1153
SPAT
Removal of sutures
1.8
8.0
138
848
N02BF02
ATC
pregabalin; oral
2.7
7.9
44
173
D05BB02
ATC
acitretin; oral
6.7
7.9
19
29
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
7.9
142
886
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.9
7.8
36
128
B03XA01
ATC
erythropoietin; parenteral
45.6
7.7
9
*
J01MA02
ATC
ciprofloxacin; systemic
1.7
7.7
177
1182
A02BC05
ATC
esomeprazole; systemic
1.7
7.7
192
1311
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
2.9
7.7
35
124
P01AB01
ATC
metronidazole; oral, rectal
1.7
7.6
215
1513
XQ845
NOMESCO Finland
Dermatoscopy
8.2
7.6
16
20
L04AA01
ATC
[U] ciclosporin
9.0
7.6
15
17
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
7.6
253
1858
B03XA02
ATC
darbepoetin alfa; parenteral
10.2
7.6
14
14
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
7.5
124
752
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
3.2
7.5
29
93
N05CF01
ATC
zopiclone; oral
1.8
7.4
140
883
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.9
7.3
100
570
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.1
7.3
31
105
TPX10
NOMESCO Finland
Implantation of vascular injection port
3.9
7.3
21
55
Z01.6
ICD-10 Finland
Radiological examination, not elsewhere classified
2.1
7.3
68
338
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
16.0
7.2
11
7
N06AX11
ATC
mirtazapine; oral
1.7
7.2
192
1328
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.3
7.2
55
252
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
2.6
7.2
41
164
Z01.2
ICD-10 Finland
Dental examination
1.6
7.1
323
2542
ZYC01
NOMESCO Finland
Remote contact by phone
2.4
7.1
49
215
N02BE01
ATC
paracetamol; systemic, rectal
1.9
7.1
509
4494
B05DA
ATC
Isotonic solutions
10.2
7.1
13
13
L04AD02
ATC
tacrolimus; systemic
6.4
7.0
17
27
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
3.8
7.0
21
57
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.3
7.0
52
236
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
6.9
109
651
N06AX16
ATC
venlafaxine; oral
1.9
6.8
99
575
G44.2
ICD-10 Finland
Tension-type headache
1.9
6.8
98
568
Z49.2
ICD-10 Finland
Other dialysis
11.1
6.8
12
11
B05DB
ATC
Hypertonic solutions
11.1
6.8
12
11
Z75.1
ICD-10 Finland
Person awaiting admission to adequate facility elsewhere
4.3
6.8
17
40
R06AE07
ATC
cetirizine; oral
1.6
6.8
277
2118
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.1
6.7
28
94
N05BA04
ATC
oxazepam; oral
1.7
6.7
143
930
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.1
6.7
66
335
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.1
6.7
27
89
D07BA04
ATC
hydrocortisone and antiseptics; topical
1.9
6.7
82
451
J02AC01
ATC
fluconazole; systemic
1.6
6.7
214
1546
R4110, ,
SPAT
2.1
6.6
68
351
J01MA12
ATC
levofloxacin; systemic
2.0
6.6
79
431
A07EC02
ATC
mesalazine; oral, rectal
2.5
6.6
40
165
R42
ICD-10 Finland
Dizziness and giddiness
1.8
6.5
102
607
SXC05
NOMESCO Finland
Other oral or dental procedure
2.1
6.5
61
304
ZX120
NOMESCO Finland
Intravenous
2.4
6.5
45
198
A04AA01
ATC
ondansetron; systemic, rectal
2.5
6.4
40
167
J01FA01
ATC
erythromycin; systemic
1.8
6.4
102
610
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.2
6.4
55
265
UKC02
NOMESCO Finland
Cystoscopy
2.2
6.4
55
265
SPAT1240
SPAT
Therapeutic discussion
1.8
6.4
94
549
L01BA01
ATC
methotrexate; systemic
3.7
6.4
20
56
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
6.3
181
1268
KBV00
NOMESCO Finland
Insertion of stent into ureter
11.2
6.3
11
10
V03AE02
ATC
sevelamer; oral
18.2
6.3
9
5
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
18.2
6.3
9
5
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.1
6.3
25
82
70600
ICD-8 Finland
Diseases of sebaceous glands, Acne necrotica
+∞
6.3
6
*
70610
ICD-8 Finland
Diseases of sebaceous glands, Acne vulgaris
+∞
6.3
6
*
K51.5
ICD-10 Finland
Left sided colitis
3.0
6.2
27
93
H02AB09
ATC
hydrocortisone; systemic
3.5
6.2
21
62
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
2.9
6.2
28
99
M79.6
ICD-10 Finland
Pain in limb
1.5
6.2
242
1823
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
7.8
6.1
13
17
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.6
6.1
35
140
SPAT1263
SPAT
Sampling
1.5
6.1
250
1898
L73.9
ICD-10 Finland
Follicular disorder, unspecified
12.7
6.1
10
8
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
6.1
333
2693
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.3
6.1
44
197
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.8
6.1
106
651
L84
ICD-10 Finland
Corns and callosities
3.4
6.0
21
63
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
230
1392
2.06
15.47
4.4
2.5
56.69
63.31
u/l
0.72
211
1304
257
1645
1.98
14.55
11.7
7.9
1.13
1.11
inr
0.31
213
1368
135
678
2.28
14.53
4.7
2.3
13.23
14.69
umol/l
1.63
130
629
368
2665
1.98
14.48
6.8
5.0
6.37
6.37
mmol/l
0.00
342
2416
442
3489
2.01
12.64
13.4
7.1
76.02
75.08
u/l
0.21
413
3322
319
2268
1.87
12.55
8.8
6.0
9.30
10.57
umol/l
2.52
298
2161
107
522
2.28
12.19
1.8
1.6
1305.33
1169.78
nmol/l
0.80
77
402
381
2895
1.86
11.82
15.4
9.0
4.12
3.93
e9/l
0.97
350
2536
198
1237
1.90
11.46
3.0
2.1
2.64
2.63
mg/l
0.03
172
1077
105
526
2.21
11.17
18.1
6.5
1.09
1.07
mmol/l
0.20
100
500
256
1759
1.79
10.74
11.2
4.9
36.87
37.41
g/l
0.86
245
1680
40
127
3.30
10.47
7.9
6.3
135.67
511.23
iu/ml
—
6
13
279
2002
1.73
9.81
12.4
6.7
1.21
1.21
mmol/l
0.09
239
1739
114
623
2.02
9.58
2.0
1.8
—
—
—
0
0
253
1777
1.73
9.53
11.9
6.4
1.22
1.21
mmol/l
0.23
231
1645
585
5365
4.40
9.29
17.6
9.4
26.84
27.19
u/l
0.16
575
5238
296
2181
1.70
9.29
3.5
2.5
74.43
71.30
nmol/l
0.94
282
2036
439
3615
1.80
9.10
6.2
3.8
9.85
8.44
mm/h
1.40
418
3405
249
1774
1.69
8.70
4.6
3.2
31.17
29.32
u/l
0.38
235
1692
26
71
3.78
8.53
1.3
1.2
—
—
—
0
0
82
415
2.13
8.42
1.5
1.3
382.54
483.34
u/ml
0.13
77
387
248
1784
1.66
8.23
2.1
1.8
97.72
96.83
pmol/l
0.12
136
969
18
38
4.85
8.16
1.0
1.0
1357.56
1707.05
miu/ml
0.72
18
38
144
901
1.79
7.89
4.1
2.8
139.70
106.21
ug/g
0.50
114
723
394
3220
1.65
7.62
5.7
3.9
324.43
1425.62
e6/l
—
7
37
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
28
88
3.29
7.48
6.3
4.6
0.28
0.33
iu/ml
0.27
14
47
209
1467
1.65
7.47
4.0
2.9
375.33
37.08
ng/l
0.49
117
744
131
818
1.77
7.17
3.8
3.2
1231.36
689.66
ng/l
1.07
103
647
127
788
1.78
7.10
1.7
1.6
238182220.32
36508362.65
pmol/l
0.94
110
693
30
102
3.04
7.06
2.5
1.6
—
—
—
0
0
473
4099
1.72
6.86
5.2
4.2
14.69
14.45
pmol/l
1.43
439
3801
207
1475
1.62
6.85
5.3
3.3
0.00
0.01
estimate
1.08
74
575
511
4531
1.85
6.80
4.8
3.4
1.30
1.24
mmol/l
0.97
490
4294
195
1373
1.62
6.76
1.6
1.4
2.35
2.10
g/l
1.03
136
881
45
196
2.40
6.60
1.9
1.6
0.00
0.03
iu/ml
—
7
30
362
2956
1.56
6.52
4.8
3.2
88.61
78.65
ug/l
0.86
344
2808
196
1393
1.60
6.49
5.3
2.8
2.34
2.35
mmol/l
1.36
185
1293
81
450
1.92
6.41
1.8
1.7
—
—
—
0
0
101
604
1.81
6.35
3.8
2.5
29.49
29.12
s
0.31
96
592
79
437
1.93
6.33
2.1
1.7
—
—
—
0
0
535
4846
1.95
6.20
5.6
4.0
4.59
4.66
mmol/l
0.95
514
4639
40
170
2.45
6.19
1.6
1.3
240.50
218.26
u/ml
0.20
31
103
71
382
1.97
6.16
9.7
4.9
1.27
1.69
mmol/l
0.64
66
327
19
53
3.67
6.08
1.8
1.8
—
—
—
0
0
11
11
10.16
6.05
8.5
6.4
—
—
—
0
0
33
130
2.63
5.97
2.0
1.6
151.69
144.23
au/ml
0.14
16
32
86
502
1.83
5.83
3.0
2.3
11.38
13.55
nmol/l
1.49
79
474
158
1093
1.60
5.76
1.8
1.5
19.37
20.19
nmol/l
0.28
138
966
164
1145
1.59
5.75
2.9
2.0
1.15
0.98
mg/l
0.25
122
843
140
942
1.63
5.71
5.4
2.4
4.25
8.19
e6/l
2.94
131
840
338
2765
1.51
5.69
5.0
3.3
0.00
2.51
estimate
0.50
77
600
22
73
3.09
5.42
1.3
1.5
—
—
—
0
0
339
2791
1.49
5.42
5.0
3.3
0.00
0.00
estimate
-0.00
74
568
440
3826
1.56
5.42
4.0
3.2
40.26
36.70
u/l
0.48
422
3672
271
2133
1.49
5.42
4.8
3.0
0.00
0.02
estimate
1.13
71
513
20
63
3.25
5.36
1.3
1.2
—
—
—
0
0
46
222
2.16
5.34
3.1
2.1
19.66
4.93
iu/ml
—
10
47
53
272
2.04
5.25
2.2
1.7
—
—
—
0
0
333
2747
1.48
5.17
5.0
3.2
0.00
0.00
estimate
0.50
78
605
91
560
1.74
5.16
3.6
2.3
5994.75
6797.21
u/l
0.09
33
244
18
56
3.28
4.93
1.3
1.6
—
—
—
0
0
523
4783
1.72
4.79
6.2
5.0
1.74
1.79
mu/l
0.43
499
4540
47
239
2.05
4.79
7.7
3.6
0.62
1.40
mmol/l
0.59
39
165
163
1179
1.52
4.78
2.4
2.2
132.92
243.89
u/l
1.25
154
1124
533
4909
1.76
4.64
22.3
11.8
139.34
139.63
mmol/l
2.62
522
4792
158
1142
1.52
4.64
6.2
4.2
91.12
94.47
%
1.11
152
1123
23
86
2.74
4.63
1.5
1.5
—
—
—
0
0
26
104
2.57
4.60
1.5
1.6
—
—
—
0
0
21
75
2.87
4.59
1.2
1.9
—
—
—
0
0
32
142
2.32
4.56
1.3
1.3
2.02
6.50
u/ml
—
5
24
529
4871
1.72
4.49
5.5
4.3
2.72
2.79
mmol/l
1.18
505
4643
533
4918
1.74
4.49
23.0
11.8
3.96
3.92
mmol/l
2.27
517
4790
29
124
2.41
4.48
1.8
1.7
—
—
—
0
0
200
1529
1.46
4.42
6.3
2.9
—
—
—
0
0
554
5182
1.88
4.28
23.4
11.4
18.89
20.55
mg/l
0.66
477
4082
38
187
2.10
4.24
1.7
1.4
—
—
—
0
0
148
1075
1.50
4.20
6.7
4.4
22.67
10.21
mg/mmol
0.73
102
716
30
135
2.29
4.16
1.9
1.9
—
—
—
0
0
21
80
2.68
4.10
1.6
1.6
—
—
—
0
0
31
143
2.23
4.06
1.9
2.0
—
—
—
0
0
523
4829
1.64
4.05
5.2
3.9
1.44
1.43
mmol/l
0.08
501
4599
190
1460
1.44
4.03
4.9
3.5
8.11
8.87
mmol/l
1.02
162
1298
481
4360
1.52
4.02
6.4
4.7
37.76
37.34
mmol/mol
0.41
457
4181
49
270
1.89
4.00
10.2
5.1
23.96
24.13
mmol/l
0.24
49
270
38
192
2.05
3.97
3.3
2.9
132.60
91.17
ng/l
0.39
30
167
40
207
2.00
3.92
1.9
1.4
—
—
—
0
0
213
1679
1.42
3.90
3.7
2.7
0.00
0.01
estimate
1.15
69
503
30
139
2.22
3.90
6.6
3.6
24.80
25.04
mmol/l
0.20
30
131
163
1227
1.45
3.83
5.7
2.7
0.32
0.38
e6/l
0.24
131
846
17
60
2.89
3.82
1.6
1.7
—
—
—
0
0
20
78
2.62
3.75
12.2
3.1
11.83
7.44
pmol/l
1.38
20
78
30
142
2.17
3.71
1.3
1.3
—
—
—
0
0
19
73
2.66
3.67
1.9
1.9
—
—
—
0
0
20
79
2.58
3.66
11.9
2.6
5.23
4.92
kpa
1.26
20
79
51
294
1.80
3.63
10.1
3.1
1.23
1.22
mmol/l
0.10
41
251
283
2368
1.37
3.54
3.8
2.8
—
—
estimate
—
0
0
198
1564
1.40
3.52
1.5
1.4
1.10
1.66
u/ml
0.50
64
428
62
384
1.69
3.45
3.3
2.8
—
—
—
0
0
16
58
2.81
3.44
1.6
1.1
167.54
254.49
mg/l
1.71
16
49
26
120
2.22
3.43
1.9
1.6
—
—
—
0
0
183
1432
1.40
3.42
5.9
2.8
16.39
46.12
e6/l
3.13
152
1040
141
1055
1.44
3.38
3.7
2.7
344.44
327.68
umol/l
1.11
122
972
77
507
1.59
3.38
8.9
7.8
103.99
104.63
mmol/l
0.63
77
507
495
4562
1.48
3.35
4.6
3.7
5.77
5.67
mmol/l
0.84
460
4281
60
372
1.68
3.33
2.9
2.3
23.99
19.77
au/ml
—
10
47
28
135
2.13
3.33
1.1
1.1
—
—
—
0
0
80
535
1.57
3.29
4.4
3.6
5.33
6.54
umol/l
0.68
70
460
56
346
1.68
3.16
1.4
1.2
24.54
31.70
au/ml
—
5
27
102
734
1.47
2.99
4.1
3.2
444.07
617.48
ng/l
0.23
56
433
592
5769
2.75
2.99
33.7
17.5
264.80
257.22
e9/l
1.96
586
5683
36
199
1.86
2.96
11.8
13.2
15.42
16.22
%
0.57
36
190
22
103
2.18
2.84
3.6
3.5
—
—
—
0
0
26
131
2.03
2.79
2.1
2.6
9.02
11.29
mg/l
0.96
26
124
56
359
1.62
2.76
3.8
3.6
4.65
4.69
pmol/l
0.13
50
321
592
5777
2.65
2.72
33.6
17.4
4.57
4.60
e12/l
0.88
585
5678
14
54
2.63
2.72
1.4
1.1
—
—
—
0
0
505
4724
1.43
2.66
18.8
10.0
94.04
95.67
ml/min/173m2
0.85
462
4188
233
1955
1.31
2.65
2.6
1.8
1.44
1.37
mmol/l
0.46
204
1734
55
356
1.60
2.62
9.5
8.9
1.20
1.26
mmol/l
0.22
55
350
152
1200
1.36
2.62
3.8
2.2
—
—
—
0
0
52
333
1.61
2.59
9.1
10.5
118.83
123.29
g/l
0.72
52
325
25
128
1.99
2.59
1.7
1.7
3.87
3.61
mmol/l
0.48
25
121
11
36
3.09
2.57
1.5
1.1
—
—
—
0
0
12
44
2.76
2.56
1.6
1.4
—
—
—
0
0
5
7
7.19
2.55
2.6
5.4
18.80
22.00
mg/l
—
5
7
41
248
1.70
2.54
2.4
1.9
47.95
38.82
nmol/l
0.94
41
242
114
863
1.40
2.53
1.7
1.9
1.43
1.40
%
0.20
103
791
20
95
2.14
2.51
1.4
1.3
—
—
—
0
0
11
37
3.01
2.50
1.1
1.1
126.55
108.38
pmol/l
0.52
11
37
9
26
3.50
2.49
5.2
2.2
—
—
—
0
0
7
16
4.41
2.48
3.1
2.9
0.60
0.62
mmol/l
—
7
16
33
189
1.79
2.46
5.6
4.0
0.71
0.61
%
0.92
33
189
27
145
1.90
2.46
1.7
1.7
417.63
410.93
mg/l
0.03
27
138
158
1268
1.33
2.43
4.7
3.2
1.02
1.02
kg/l
0.26
109
807
15
64
2.38
2.40
1.5
1.7
—
—
—
0
0
39
237
1.69
2.38
1.9
1.7
—
—
—
0
0
42
261
1.65
2.37
1.3
1.4
—
—
—
0
0
10
33
3.06
2.36
1.9
3.6
1265.60
581.36
u/ml
—
10
33
206
1725
1.30
2.32
2.0
1.8
—
—
—
0
0
9
28
3.25
2.31
1.1
1.7
—
—
—
0
0
24
127
1.93
2.29
2.3
2.3
209.00
295.58
ug/l
0.41
19
120
58
396
1.51
2.22
5.1
5.1
—
—
—
0
0
35
212
1.69
2.18
1.4
1.7
13.50
6.05
u/ml
—
7
56
66
465
1.47
2.17
3.7
3.4
32.20
31.42
%
0.24
49
334
7
19
3.71
2.15
1.4
1.1
81.43
98.16
%
—
7
19
9
31
2.93
2.08
1.0
1.2
—
—
—
0
0
10
37
2.73
2.08
3.5
4.1
—
—
—
0
0
13
56
2.35
2.06
1.4
1.3
—
—
—
0
0
26
147
1.80
2.05
5.1
7.6
1.55
1.51
%
0.14
26
134
8
26
3.10
2.02
1.4
1.4
—
—
—
0
0
32
195
1.68
1.97
6.6
9.6
24.19
24.36
mmol/l
0.08
32
185
21
113
1.89
1.94
1.6
1.3
2.00
4.93
u/ml
0.71
11
41
47
318
1.52
1.90
5.0
2.3
65.51
80.69
ml/min/173m2
1.42
28
129
12
52
2.33
1.88
1.2
1.4
—
—
—
0
0
6
17
3.55
1.84
1.0
2.8
—
—
—
0
0
6
17
3.55
1.84
1.0
2.8
—
—
—
0
0
33
207
1.63
1.84
1.6
1.3
—
—
—
0
0
12
53
2.29
1.81
1.2
1.4
—
—
—
0
0
12
53
2.29
1.81
1.2
1.4
—
—
—
0
0
90
696
1.34
1.77
3.7
2.5
3.16
3.66
e6/l
0.15
51
309
53
374
1.46
1.76
9.0
10.5
0.63
0.68
mmol/l
0.03
46
311
96
751
1.33
1.75
3.8
2.4
1.54
0.99
e6/l
0.76
58
360
6
18
3.36
1.75
1.0
1.7
—
—
—
0
0
20
110
1.85
1.75
1.6
1.3
3.40
4.02
u/ml
—
10
47
90
699
1.34
1.72
5.0
2.3
2.41
2.42
mmol/l
0.25
81
621
18
96
1.90
1.72
1.4
1.2
—
—
—
0
0
5
13
3.87
1.72
4.8
2.6
10.00
11.01
kpa
—
5
13
5
13
3.87
1.72
4.8
2.6
5.42
4.66
kpa
—
5
13
19
104
1.85
1.69
1.3
1.1
—
—
—
0
0
12
55
2.21
1.68
1.2
1.4
—
—
—
0
0
12
55
2.21
1.68
2.1
1.6
—
—
—
0
0
12
55
2.21
1.68
1.2
1.4
—
—
—
0
0
12
55
2.21
1.68
1.2
1.4
—
—
—
0
0
43
294
1.50
1.68
1.8
1.6
7.65
7.54
u/l
0.03
32
243
6
19
3.18
1.66
1.0
1.8
—
—
—
0
0
6
19
3.18
1.66
1.2
3.0
210.67
189.68
u/l
—
6
19
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
8
31
2.60
1.66
1.5
1.1
—
—
—
0
0
10
41
2.46
1.65
1.0
1.1
—
—
—
0
0
112
906
1.29
1.61
1.3
1.3
2.77
8.08
u/ml
1.71
44
364
54
390
1.42
1.61
1.1
1.0
—
—
—
0
0
6
20
3.02
1.58
1.0
1.8
—
—
—
0
0
16
85
1.91
1.56
1.7
1.4
—
—
—
0
0
5
15
3.35
1.52
1.6
1.1
—
—
—
0
0
6
21
2.88
1.51
2.8
2.3
754.67
536.38
ml
—
6
13
6
22
2.74
1.43
1.0
1.4
—
—
—
0
0
9
39
2.33
1.43
1.1
1.2
—
—
—
0
0
66
504
1.35
1.43
1.2
1.3
225.73
158.46
u/ml
0.31
22
197
14
74
1.91
1.40
1.2
1.8
2.13
1.14
ratio
—
7
42
5
17
2.96
1.36
1.0
1.2
14.20
14.88
u/l
—
5
17
5
18
2.79
1.28
1.6
1.4
—
—
—
0
0
12
62
1.95
1.28
3.9
2.2
—
—
—
0
0
6
25
2.41
1.24
1.5
2.0
—
—
—
0
0
10
49
2.06
1.22
1.3
1.3
—
—
—
0
0
13
71
1.85
1.20
1.2
1.2
—
—
—
0
0
13
71
1.85
1.20
1.2
1.2
—
—
—
0
0
15
86
1.76
1.20
1.8
1.6
—
—
—
0
0
10
50
2.02
1.17
1.5
1.3
153.48
192.78
pmol/l
—
10
50
22
142
1.57
1.16
1.3
1.2
—
—
—
0
0
16
95
1.70
1.14
1.1
1.1
—
1.99
—
0
25
117
993
1.22
1.13
1.4
1.3
17.44
25.51
iu/ml
0.86
27
278
7
30
2.35
1.12
1.1
2.2
—
—
—
0
0
50
382
1.34
1.12
9.2
10.4
12.48
13.46
kpa
0.86
50
367
50
382
1.34
1.12
9.3
10.4
5.05
5.12
kpa
0.24
50
366
5
21
2.39
1.09
1.0
1.0
0.18
0.36
u/ml
—
5
21
461
4408
1.20
1.08
3.8
3.8
—
—
—
0
0
67
537
1.28
1.07
2.9
2.6
0.58
0.72
ug/l
0.89
30
282
14
82
1.72
1.06
3.9
2.7
32.36
25.44
nmol/l
0.59
14
77
9
48
1.89
1.01
1.3
1.3
—
—
—
0
0
18
115
1.58
1.00
1.3
1.1
—
—
—
0
0
7
35
2.01
1.00
1.3
1.1
—
—
—
0
0
49
381
1.31
0.99
1.4
1.3
250.63
247.47
miu/ml
0.02
21
193
15
93
1.63
0.94
2.6
2.2
130.07
133.07
g/l
0.28
15
73
21
142
1.50
0.93
1.3
1.1
—
—
—
0
0
50
394
1.29
0.93
1.6
1.6
339.33
307.94
mu/l
0.30
44
355
9
52
1.74
0.92
1.3
1.2
—
—
—
0
0
9
52
1.74
0.92
1.3
1.2
—
—
—
0
0
85
714
1.22
0.92
3.9
3.7
22.15
22.11
%
0.00
30
271
6
28
2.15
0.91
1.5
1.1
—
—
—
0
0
51
404
1.29
0.91
1.5
1.4
—
—
—
0
0
21
143
1.49
0.91
1.5
1.9
—
—
—
0
0
105
905
1.19
0.88
4.5
4.1
1.62
1.90
ug/l
0.29
97
820
14
88
1.61
0.85
1.4
1.1
—
—
—
0
0
18
121
1.50
0.83
1.3
1.4
201.02
309.37
ug/g
—
8
68
8
46
1.75
0.82
2.6
1.6
—
—
—
0
0
36
277
1.32
0.81
8.3
4.4
3.88
21.35
ug/l
0.54
30
212
36
277
1.32
0.81
1.4
1.9
6.51
3.48
mg/l
0.96
31
196
22
304
0.71
0.80
1.1
1.1
1.46
1.51
g/l
0.33
22
304
12
74
1.63
0.78
1.3
1.9
0.00
0.00
g/l
-0.00
12
74
0
28
0.00
0.76
0.0
1.5
—
—
—
0
0
9
53
1.71
0.75
6.1
5.2
16.33
528.35
u/ml
—
9
48
9
53
1.71
0.75
1.3
1.2
—
—
—
0
0
9
54
1.68
0.74
1.3
1.2
—
—
—
0
0
29
219
1.34
0.74
1.1
1.1
1.81
3.11
u/ml
0.59
21
107
181
1652
1.14
0.73
3.2
2.5
—
—
—
0
0
5
25
2.01
0.73
4.4
1.2
—
—
—
0
0
9
56
1.62
0.72
1.1
1.1
—
—
—
0
0
9
56
1.62
0.72
1.3
1.2
—
—
—
0
0
11
68
1.63
0.72
1.3
1.1
—
—
—
0
0
11
68
1.63
0.72
1.3
1.1
—
—
—
0
0
23
308
0.74
0.71
1.1
1.1
0.97
0.87
g/l
0.94
23
308
5
26
1.93
0.70
1.4
2.2
158.20
134.19
%
—
5
26
28
213
1.33
0.69
1.9
1.6
—
—
—
0
0
10
62
1.62
0.65
1.3
1.2
—
—
—
0
0
5
29
1.73
0.64
1.4
1.0
—
—
—
0
0
15
104
1.45
0.63
1.9
2.5
0.50
1.99
index
—
8
56
5
30
1.67
0.61
1.6
2.3
1.17
1.19
mmol/l
—
5
30
5
30
1.67
0.61
1.6
2.3
104.00
105.40
mmol/l
—
5
30
167
1535
1.12
0.60
3.1
2.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
48
402
1.21
0.58
1.8
1.5
19.68
18.27
iu/l
0.11
40
330
12
81
1.49
0.57
1.3
1.9
0.00
0.00
g/l
-0.00
12
74
6
37
1.63
0.55
1.2
1.2
—
—
—
0
0
10
66
1.52
0.53
1.3
1.1
—
—
—
0
0
24
188
1.29
0.52
1.1
1.1
2.40
2.08
u/ml
0.09
17
96
7
49
1.43
0.46
7.4
2.7
11.14
19.81
u/ml
—
7
49
14
105
1.34
0.41
1.2
1.1
3.49
1.89
eliau/ml
—
9
50
0
17
0.00
0.40
0.0
1.0
—
35.90
—
0
10
0
17
0.00
0.40
0.0
1.0
—
522.80
—
0
10
5
34
1.47
0.40
2.8
1.5
—
—
—
0
0
5
34
1.47
0.40
2.8
1.5
—
—
—
0
0
5
34
1.47
0.40
2.8
1.5
—
—
—
0
0
37
431
0.85
0.40
1.2
1.5
0.94
0.93
ratio
0.07
23
277
37
431
0.85
0.40
1.2
1.5
1.40
1.18
ratio
0.57
23
277
37
430
0.85
0.39
1.2
1.5
1.34
1.15
ratio
0.72
23
276
13
98
1.33
0.37
3.4
3.7
25.79
22.00
mg/l
—
8
70
21
171
1.24
0.36
1.7
2.1
3.04
4.38
iu/l
—
9
71
17
135
1.27
0.35
1.7
1.4
58.82
172.92
pmol/l
0.75
17
130
15
189
0.79
0.35
1.3
1.3
3.56
3.17
ug/l
0.14
15
178
37
423
0.87
0.33
1.2
1.5
—
—
—
0
0
29
338
0.85
0.33
2.2
1.8
—
—
—
0
0
26
304
0.85
0.31
1.5
1.6
61.73
55.37
ug/l
0.34
26
304
20
166
1.21
0.30
1.0
1.0
1.62
6.63
u/ml
2.18
14
89
21
249
0.84
0.29
1.2
1.3
—
—
—
0
0
77
832
0.91
0.28
1.6
1.7
4.53
3.46
ratio
0.53
53
609
8
62
1.29
0.28
1.0
1.5
0.29
0.48
nmol/l
—
8
57
8
65
1.23
0.27
2.0
1.4
—
—
—
0
0
17
141
1.21
0.26
1.0
1.0
0.16
0.39
u/ml
—
8
40
36
320
1.13
0.26
1.4
1.4
—
—
—
0
0
34
301
1.14
0.26
1.4
1.5
—
—
—
0
0
5
40
1.25
0.22
1.0
1.1
7.60
8.25
mm/h
—
5
40
28
248
1.14
0.22
1.4
2.4
17.87
44.89
u/ml
1.67
28
240
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.9
—
43.94
—
0
12
33
365
0.90
0.20
1.7
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
1.13
—
0
14
469
4636
1.05
0.19
27.0
14.2
13.50
13.23
%
4.61
461
4586
6
53
1.13
0.18
1.2
1.9
—
—
—
0
0
101
1057
0.95
0.17
2.9
2.2
—
—
—
0
0
14
163
0.86
0.17
1.4
1.3
—
—
—
0
0
8
71
1.13
0.16
1.9
1.5
0.52
0.51
e9/l
—
8
71
22
197
1.12
0.15
1.2
1.1
1.66
6.66
u/ml
3.15
13
117
50
531
0.94
0.14
1.5
1.5
—
—
—
0
0
62
650
0.95
0.12
1.3
1.6
3.66
3.40
mmol/l
0.54
40
432
13
117
1.11
0.08
1.1
2.3
—
—
—
0
0
116
1138
1.02
0.06
1.7
1.6
—
—
—
0
0
35
336
1.04
0.05
2.0
1.6
0.34
0.28
mg/l
0.23
14
138
33
317
1.04
0.05
1.8
1.9
—
—
—
0
0
88
894
0.98
0.03
2.9
2.0
—
—
—
0
0
16
168
0.95
0.02
1.4
1.6
—
—
—
0
0
19
186
1.02
0.00
3.1
2.5
9.38
5.88
umol/l
0.31
13
145
6
68
0.88
0.00
1.2
1.1
1.53
1.43
g/l
—
6
60
5
54
0.93
0.00
21.8
24.2
1846.60
1564.63
nmol/l
—
5
54
0
9
0.00
-0.00
0.0
8.4
—
5.94
—
0
9
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
12.76
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
1.20
—
0
6
0
6
0.00
-0.00
0.0
3.0
—
0.50
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
11.5
—
10.80
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint L12_ACNE_NAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ACNE_NAS | 1.745 [1.23, 2.48] | 0.002 |
| Birth year | 1.001 [0.99, 1.01] | 0.806 |
During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 1370 females with L12_ACNE_NAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ACNE_NAS | 2.269 [1.71, 3.0] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 98 out of 1383 males with L12_ACNE_NAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_ACNE_NAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.213% | 0.453% |
| 5 | 1.239% | 2.551% |
| 10 | 3.12% | 6.449% |
| 15 | 5.814% | 12.242% |
| 20 | 11.313% | 20.698% |
Relationships between endpoints
↥Index endpoint: L12_ACNE_NAS – Other and unspecified acne
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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