rheumatic fever: Rheumatic fever (RF) is a multisystem inflammatory disease occurring as a post-infectious, nonsuppurative sequela of untreated streptococcus pyogenes (Group A streptococcus [GAS]) pharyngitis, and mainly occurs in individuals aged 5 to 15 years. The most common presenting signs are fever, migratory polyarthritis and carditis.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
1433 |
6. Filter based on genotype QC (FinnGen only) |
1242 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Rheumatic fever incl heart disease
based on the number of shared cases.
Similar with more cases:
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 20505 | 10490 | 9486 |
| Only index persons | 9214 | 4842 | 4372 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.29 | 0.30 | 0.27 |
| Only index persons | 0.17 | 0.18 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 61.81 | 65.18 | 57.95 |
| Only index persons | 51.22 | 55.20 | 46.81 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1242 | 567 | 675 |
| Unadjusted period prevalence (%) | 0.26 | 0.20 | 0.31 |
| Median age at first event (years) | 51.77 | 47.36 | 55.47 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1291
- Matched controls
- 12910
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
20.5
290.9
234
138
I06.9
ICD-10 Finland
Rheumatic aortic valve disease, unspecified
2331.5
222.4
209
*
B01AA03
ATC
warfarin; systemic
4.1
133.9
632
2470
201
Kela drug reimbursment
Chronic cardiac insufficiency
5.5
133.6
312
711
I34.2
ICD-10 Finland
Nonrheumatic mitral (valve) stenosis
44.8
120.9
72
17
I35.0
ICD-10 Finland
Aortic (valve) stenosis
5.0
106.5
267
639
C01AA05
ATC
digoxin; systemic
4.0
101.7
373
1190
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
7.4
99.1
154
233
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
14.6
97.2
89
65
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
9.8
94.1
113
125
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
5.7
92.7
191
383
5253
FHL
Cardiac lung machine
12.7
86.5
86
72
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.3
84.1
435
1711
I05.0
ICD-10 Finland
Mitral stenosis
+∞
80.0
76
*
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
5.9
79.6
154
290
5273
FHL
Repair with flap prosthesis or graft
145.8
77.9
82
6
K83
ICPC
Heart valve disease NOS
15.2
76.3
68
47
I06.0
ICD-10 Finland
Rheumatic aortic stenosis
+∞
75.8
72
*
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
21.3
75.3
57
28
I08.0
ICD-10 Finland
Disorders of both mitral and aortic valves
+∞
72.6
69
*
I01.0
ICD-10 Finland
Acute rheumatic pericarditis
+∞
71.5
68
*
XF640, ,
NOMESCO Finland
7.0
69.8
111
171
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
4.8
69.8
174
408
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.8
69.8
561
2770
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
6.4
67.2
117
198
3950A
ICD-9 Finland
Diseases of aortic valve, Rheumatic aortic stenosis
+∞
63.0
60
*
I50.9
ICD-10 Finland
Heart failure, unspecified
2.7
59.5
436
2021
62
HP
Catheterization and pressure measurement of the right side of the heart
22.2
58.0
43
20
I05.2
ICD-10 Finland
Mitral stenosis with insufficiency
+∞
57.7
55
*
I50.0
ICD-10 Finland
Congestive heart failure
3.2
56.6
269
981
39501
ICD-8 Finland
Diseases of aortic valve, Cum insufficientia (febris rheumatica inactiva)
+∞
55.6
53
*
I34.1
ICD-10 Finland
Mitral (valve) prolapse
6.6
55.0
92
149
C03CA01
ATC
furosemide; systemic
2.5
54.1
704
4235
I05.1
ICD-10 Finland
Rheumatic mitral insufficiency
+∞
53.5
51
*
I06.1
ICD-10 Finland
Rheumatic aortic insufficiency
+∞
50.3
48
*
42700
ICD-8 Finland
Symptomatic heart disease, Congestive heart failure
12.4
49.0
49
41
C07AA07
ATC
sotalol; systemic
4.2
48.5
138
356
3952A
ICD-9 Finland
Diseases of aortic valve, Rheumatic aortic stenosis with insufficiency
+∞
48.2
46
*
3951A
ICD-9 Finland
Diseases of aortic valve, Rheumatic aortic insufficiency
+∞
47.2
45
*
I34.9
ICD-10 Finland
Nonrheumatic mitral valve disorder, unspecified
12.3
43.0
43
36
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
4.4
42.2
111
269
I06.2
ICD-10 Finland
Rheumatic aortic stenosis with insufficiency
+∞
41.9
40
*
81
HP
Angiography of the heart and coronary arteries
3.2
41.8
187
651
C03DA01
ATC
spironolactone; oral
2.7
41.6
278
1204
39097
ICD-8 Finland
Rheumatic fever without mention of heart involvement, Suspecta
+∞
40.8
39
*
39500
ICD-8 Finland
Diseases of aortic valve, Cum stenosi (febris rheumatica inactiva)
+∞
40.8
39
*
I05.9
ICD-10 Finland
Mitral valve disease, unspecified
+∞
39.8
38
*
4241B
ICD-9 Finland
Other diseases of endocardium, Aortic valve disorders[STENOSIS VALVULAE AORTAE (NON RHEUMATICA)]
54.1
39.8
47
9
42792
ICD-8 Finland
Symptomatic heart disease, Fibrillatio auricularis
8.0
39.3
54
70
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
6.4
37.2
63
103
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.2
36.0
401
2169
I50.1
ICD-10 Finland
Left ventricular failure
3.2
35.8
157
538
207
Kela drug reimbursment
Chronic arrhythmias
2.3
35.1
328
1646
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
6.4
34.5
58
94
39401
ICD-8 Finland
Diseases of mitral valve, Cum insufficientia (febris rheumatica inactiva)
+∞
33.5
32
*
4241A
ICD-9 Finland
Other diseases of endocardium, Aortic valve disorders[INSUFFICIENTIA VALVULAE AORTAE (NON RHEUMATICA)]
92.6
32.9
36
*
39502
ICD-8 Finland
Diseases of aortic valve, Cum stenosi et insufficientia (febris rheumatica inactiva)
+∞
32.4
31
*
FKD00
NOMESCO Finland
Replacement of mitral valve using mechanical prosthesis
61.6
31.2
36
6
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
11.7
30.1
31
27
61
HP
Catheterization and pressure measurement of the left side of the heart
4.8
29.9
69
150
3941A
ICD-9 Finland
Diseases of mitral valve, Rheumatic mitral insufficiency
+∞
28.2
27
*
I34.0
ICD-10 Finland
Mitral (valve) insufficiency
5.6
28.1
54
100
TFP20
NOMESCO Finland
Cardiodefibrillation
2.8
27.9
150
574
21
HP
Aortic Valve Replacement (AVR)
43.6
27.8
34
8
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
27.4
289
1508
AB2
HP
AVR bio, stent
8.7
26.7
34
40
I00
ICD-10 Finland
Rheumatic fever without mention of heart involvement
+∞
26.1
25
*
39099
ICD-8 Finland
Rheumatic fever without mention of heart involvement, Unspecified
+∞
26.1
25
*
AN1
HP
Coronary angiography
2.3
26.0
220
1045
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
26.0
352
2013
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
2.9
26.0
132
490
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
2.8
25.7
136
516
C07AB02
ATC
metoprolol; systemic
2.0
25.4
384
2278
C07AB07
ATC
bisoprolol; oral
1.9
25.2
741
5438
I07.1
ICD-10 Finland
Tricuspid insufficiency
+∞
25.1
24
*
FKD10
NOMESCO Finland
Replacement of mitral valve using biological prosthesis
30.7
25.1
33
11
4241C
ICD-9 Finland
Other diseases of endocardium, Aortic valve disorders[INSUFFICIENTIA/STENOSIS VALVULAE AORTAE (NON RHEUM)]
132.6
24.7
26
*
39199
ICD-8 Finland
Rheumatic fever with heart involvement, Other active rheumatic heart disease
+∞
24.0
23
*
3940A
ICD-9 Finland
Diseases of mitral valve, Mitral stenosis
+∞
24.0
23
*
39197
ICD-8 Finland
Rheumatic fever with heart involvement, Suspecta
+∞
23.0
22
*
39400
ICD-8 Finland
Diseases of mitral valve, Cum stenosi (febris rheumatica inactiva)
+∞
23.0
22
*
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
2.5
22.9
152
646
B01AB05
ATC
enoxaparin; parenteral
1.9
22.7
426
2698
5284
FHL
Mitral defect correction with flap prosthesis or graft
234.0
22.7
23
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.1
22.5
275
1505
C01BD01
ATC
amiodarone; systemic
3.8
21.8
67
182
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.9
21.7
109
401
L04AA01
ATC
[U] ciclosporin
7.5
21.7
31
42
I35.9
ICD-10 Finland
Aortic valve disorder, unspecified
6.7
20.9
33
50
3960A
ICD-9 Finland
Diseases of mitral and aortic valves, Mitral valve stenosis and aortic valve stenosis
+∞
20.9
20
*
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
4.8
20.7
47
101
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
4.1
19.7
54
135
R50.9
ICD-10 Finland
Fever, unspecified
2.0
19.0
222
1189
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
3.8
18.9
58
157
39409
ICD-8 Finland
Diseases of mitral valve, Unspecified
+∞
18.8
18
*
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
2.8
18.5
97
365
XFE00
NOMESCO Finland
Epicardial ultrasonography
3.9
18.4
54
142
4240A
ICD-9 Finland
Other diseases of endocardium, Mitral valve disorders[INSUFFICIENTIA VALVULAE MITRALIS (NON RHEUMATICA)]
25.4
18.3
25
10
WX872
NOMESCO Finland
Intensive care
2.9
18.0
87
313
K84
ICPC
Heart disease other
3.6
18.0
61
177
4130B
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),AHTAUTUNUT]
3.7
18.0
57
158
M04AA01
ATC
allopurinol; systemic
2.0
18.0
243
1369
127
Kela drug reimbursment
Transplant complication
6.1
17.8
31
52
J01DA01
ATC
[U] cefalexin
1.7
17.3
785
6214
XF404
NOMESCO Finland
Ambulatory ECG
2.3
17.1
140
651
L04AA06
ATC
mycophenolic acid; systemic
5.3
17.1
34
65
I34.8
ICD-10 Finland
Other nonrheumatic mitral valve disorders
50.7
17.0
20
*
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.7
16.7
415
2803
3942A
ICD-9 Finland
Diseases of mitral valve, Mitral stenosis with insufficiency
+∞
16.7
16
*
K78
ICPC
Atrial fibrillation/flutter
2.2
16.7
154
753
AC2
HP
MVR bio
91.3
16.6
18
*
C02EA02, ,
ATC
2.5
16.3
105
438
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
16.0
617
4654
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
2.6
15.7
93
373
39402
ICD-8 Finland
Diseases of mitral valve, Cum stenosi et insufficientia (febris rheumatica inactiva)
+∞
15.7
15
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.8
15.5
48
131
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
7.1
15.3
23
33
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.1
15.2
64
213
I33.9
ICD-10 Finland
Acute endocarditis, unspecified
29.0
15.2
20
7
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.8
15.2
76
279
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.1
15.1
155
788
AP2
HP
Catheterization of the right side of the heart
18.6
14.7
22
12
J01FF01
ATC
clindamycin; systemic
1.7
14.6
327
2134
39509
ICD-8 Finland
Diseases of aortic valve, Unspecified
+∞
14.6
14
*
I01.9
ICD-10 Finland
Acute rheumatic heart disease, unspecified
+∞
14.6
14
*
I08.1
ICD-10 Finland
Disorders of both mitral and tricuspid valves
+∞
14.6
14
*
39403
ICD-8 Finland
Diseases of mitral valve, Operata (febris rheumatica inactiva)
+∞
14.6
14
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.1
14.6
146
735
42798
ICD-8 Finland
Symptomatic heart disease, Alia arrhytmia definita
5.6
14.3
27
49
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
3.7
14.2
45
125
L01BA01
ATC
methotrexate; systemic
3.2
14.0
56
181
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
13.9
379
2601
FCA60
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of composite graft with mechanical valve prosthesis
24.1
13.8
19
8
TFC20
NOMESCO Finland
Catheterisation of both sides of heart
20.3
13.8
20
10
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
2.5
13.7
91
385
A12BA01
ATC
potassium chloride; oral
2.2
13.7
118
560
R04.0
ICD-10 Finland
Epistaxis
2.2
13.6
127
622
22
HP
Mitral valve Replacement (MVR)
76.0
13.6
15
*
42410
ICD-8 Finland
Chronic disease of endocardium, Aortae, non operata
+∞
13.6
13
*
I08.3
ICD-10 Finland
Combined disorders of mitral, aortic and tricuspid valves
+∞
13.6
13
*
I07.2
ICD-10 Finland
Tricuspid stenosis with insufficiency
+∞
13.6
13
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.4
13.4
92
395
FGC10
NOMESCO Finland
Annuloplasty of tricuspid valve using prosthetic ring
26.0
13.4
18
7
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
13.3
365
2503
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.7
13.2
260
1634
4289X
ICD-9 Finland
Heart failure, unspecified
4.6
13.1
31
69
R06.0
ICD-10 Finland
Dyspnoea
1.6
13.1
378
2626
C08DA01
ATC
verapamil; systemic
2.4
12.6
88
381
H02AB06
ATC
prednisolone; systemic
1.5
12.6
586
4532
39503
ICD-8 Finland
Diseases of aortic valve, Operata (febris rheumatica inactiva)
+∞
12.5
12
*
Z95.3
ICD-10 Finland
Presence of xenogenic heart valve
9.4
12.5
25
27
ZXD05
NOMESCO Finland
Urgent procedure
1.6
12.2
386
2731
M01AE01
ATC
ibuprofen; systemic, rectal
0.7
11.9
745
8718
C09AA02
ATC
enalapril; systemic
1.6
11.9
300
2009
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.0
11.7
126
651
J01CA04
ATC
amoxicillin; systemic
1.6
11.7
922
7930
L04AD01
ATC
ciclosporin; systemic
4.5
11.7
28
63
C01DA14
ATC
isosorbide mononitrate; oral
1.6
11.7
323
2211
I48.2
ICD-10 Finland
Chronic atrial fibrillation
2.3
11.7
88
395
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
11.7
435
3191
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.6
11.6
398
2865
I48.1
ICD-10 Finland
Persistent atrial fibrillation
2.5
11.5
74
309
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.0
11.5
138
742
74673
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae aortae
+∞
11.5
11
*
I09.0
ICD-10 Finland
Rheumatic myocarditis
+∞
11.5
11
*
J01MA12
ATC
levofloxacin; systemic
1.7
11.4
253
1635
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
4.2
11.4
30
73
25
HP
Valve and coronary artery bypass surgery
17.2
11.2
17
10
I50
ICD-10 Finland
Heart failure
2.4
11.1
75
321
N05BA01
ATC
diazepam; systemic, rectal
1.8
11.0
175
1030
C01BA03
ATC
disopyramide; systemic
4.7
11.0
25
54
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
12.0
10.8
19
16
L04AX01
ATC
azathioprine; systemic
2.8
10.7
55
205
ZSF00
NOMESCO Finland
Procedure related to previous procedure classified in chapter F
18.0
10.7
16
9
AD1
HP
TVP
28.3
10.7
14
5
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
10.7
223
1418
41399
ICD-8 Finland
Angina pectoris, Without mention of hypertensive disease
3.6
10.6
35
100
J01FA06
ATC
roxithromycin; oral
1.5
10.5
467
3537
J01FA10
ATC
azithromycin; systemic
1.5
10.5
563
4431
24
HP
Multi-valve repair or other valve surgery
110.9
10.4
11
*
42100
ICD-8 Finland
Acute and subacute endocarditis, Acute and subacute bacterial endocarditis
+∞
10.4
10
*
39604
ICD-8 Finland
Diseases of mitral and aortic valves, Non operata
+∞
10.4
10
*
I01.1
ICD-10 Finland
Acute rheumatic endocarditis
+∞
10.4
10
*
H02AB07
ATC
prednisone; oral
1.7
10.3
189
1159
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.5
10.2
402
2966
7865A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Chest pain
3.2
9.9
39
125
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
1.9
9.8
125
686
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
1.5
9.8
334
2388
Z95.4
ICD-10 Finland
Presence of other heart-valve replacement
13.5
9.7
16
12
4240X
ICD-9 Finland
Other diseases of endocardium, Mitral valve disorders[ALIUD VITIUM VALVULAE MITRALIS (NON RHEUMATICUM)]
55.4
9.7
11
*
I71.9
ICD-10 Finland
Aortic aneurysm of unspecified site, without mention of rupture
4.0
9.6
27
69
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
9.4
288
2005
42400
ICD-8 Finland
Chronic disease of endocardium, Mitralis, non-operata
100.8
9.4
10
*
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
9.4
280
1939
42411
ICD-8 Finland
Chronic disease of endocardium, Aortae, operata
+∞
9.4
9
*
74679
ICD-8 Finland
Congenital anomalies of heart, Aliae malformationes valvulae aortae sive ventriculi sinistri
+∞
9.4
9
*
I09.9
ICD-10 Finland
Rheumatic heart disease, unspecified
+∞
9.4
9
*
I01.8
ICD-10 Finland
Other acute rheumatic heart disease
+∞
9.4
9
*
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
3.2
9.4
36
114
Z3231
NOMESCO Finland
Registered nurse
1.5
9.4
331
2380
J45.9
ICD-10 Finland
Asthma, unspecified
1.6
9.4
233
1546
C01BA01
ATC
quinidine; oral
4.6
9.3
22
49
ZXE20
NOMESCO Finland
More than three and less than five hours
1.7
9.3
175
1079
I42.0
ICD-10 Finland
Dilated cardiomyopathy
2.8
9.3
46
169
A41.9
ICD-10 Finland
Sepsis, unspecified
2.4
9.2
63
271
FPE00
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with ventricular electrode
2.5
9.2
56
228
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.9
9.2
43
153
D64.9
ICD-10 Finland
Anaemia, unspecified
1.7
9.2
178
1107
TK800
NOMESCO Finland
Hemodialysis
3.3
9.1
34
106
Z2221
NOMESCO Finland
Medical doctor
1.5
8.9
313
2243
J46
ICD-10 Finland
Status asthmaticus
2.9
8.9
41
145
7806A
ICD-9 Finland
General symptoms, Pyrexia of unknown origin
6.9
8.9
21
31
4130X
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),MÄÄRITTELEMÄT]
2.5
8.7
56
234
Z94.0
ICD-10 Finland
Kidney transplant status
6.7
8.7
21
32
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
2.8
8.6
43
159
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
2.3
8.6
62
274
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
3.0
8.5
37
126
K99
ICPC
Cardiovascular disease other
2.7
8.5
46
177
P01BA02
ATC
hydroxychloroquine; oral
2.0
8.4
88
450
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.8
8.4
143
856
L54.0*I00
ICD-10 Finland
Erythema marginatum in acute rheumatic fever
+∞
8.3
8
*
3910A
ICD-9 Finland
Rheumatic fever with heart involvement, Acute rheumatic pericarditis
+∞
8.3
8
*
39601
ICD-8 Finland
Diseases of mitral and aortic valves, Mitralium operata
+∞
8.3
8
*
39609
ICD-8 Finland
Diseases of mitral and aortic valves, Unspecified
+∞
8.3
8
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.7
8.3
161
1000
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
8.3
267
1875
N05CF01
ATC
zopiclone; oral
1.4
8.2
426
3294
71239
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides NUD
4.4
8.2
20
46
H02AB04
ATC
methylprednisolone; systemic
1.7
8.2
171
1085
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
8.1
391
2978
A46
ICD-10 Finland
Erysipelas
1.6
8.1
194
1273
4660A
ICD-9 Finland
Acute bronchitis and bronchiolitis, Acute bronchitis
4.1
8.1
22
55
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.6
8.0
200
1325
5311
FHL
Bypass surgery in one vein
22.2
8.0
11
5
I34.01
ICD-10 Finland
Mitral (valve) regurgitation NOS or of specified cause, except rheumatic
7.8
7.9
17
22
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.9
7.9
95
512
PD5AD
NOMESCO Finland
CT of aorta
2.8
7.8
39
144
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
1.9
7.8
94
506
50099
ICD-8 Finland
Hypertrophy of tonsils and adenoids
2.0
7.8
86
449
AC4
HP
MVP
9.5
7.8
15
16
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
4.2
7.7
20
48
R02
ICPC
Shortness of breath/dyspnoea
1.7
7.7
164
1043
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
2.5
7.7
47
192
K92.1
ICD-10 Finland
Melaena
1.9
7.7
91
487
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
7.6
212
1440
ZX120
NOMESCO Finland
Intravenous
1.8
7.6
116
673
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.6
7.6
164
1048
FCA50
NOMESCO Finland
Resection and reconstruction of ascending aorta using tube graft
11.9
7.6
13
11
J45.1
ICD-10 Finland
Nonallergic asthma
1.9
7.6
88
468
I48.3
ICD-10 Finland
Typical atrial flutter
4.1
7.6
20
49
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
7.2
7.5
17
24
4210A
ICD-9 Finland
Acute and subacute endocarditis, Acute and subacute bacterial endocarditis
80.5
7.4
8
*
I25.5
ICD-10 Finland
Ischaemic cardiomyopathy
2.6
7.4
41
160
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.1
7.4
70
346
4140X
ICD-9 Finland
Other forms of chronic ischaemic heart disease, Coronary atherosclerosis[ATHEROSCLEROSIS ARTER CORON CORDIS,MÄÄRITTELEMÄT]
3.8
7.4
22
59
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
7.3
442
3493
Z49.1
ICD-10 Finland
Extracorporeal dialysis
3.6
7.3
23
64
C02EA01, ,
ATC
3.1
7.3
29
94
39899
ICD-8 Finland
Other heart disease, specified as rheumatic
+∞
7.3
7
*
I07.9
ICD-10 Finland
Tricuspid valve disease, unspecified
+∞
7.3
7
*
74659
ICD-8 Finland
Congenital anomalies of heart, Maleformatio valvulae mitralis
+∞
7.3
7
*
3900A
ICD-9 Finland
Rheumatic fever without mention of heart involvement[FEBRIS RHEUMATICA, MORBO CORDIS NON INDICATO]
+∞
7.3
7
*
I02.9
ICD-10 Finland
Rheumatic chorea without heart involvement
+∞
7.3
7
*
I35
ICD-10 Finland
Nonrheumatic aortic valve disorders
7.4
7.2
16
22
4140B
ICD-9 Finland
Other forms of chronic ischaemic heart disease, Coronary atherosclerosis[ATHEROSCLEROSIS ARTER CORON CORDIS,AHTAUTUNUT]
3.1
7.2
29
95
4412A
ICD-9 Finland
Aortic aneurysm, Thoracic aneurysm without mention of rupture
30.2
7.2
9
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
1.9
7.1
86
463
I40.9
ICD-10 Finland
Acute myocarditis, unspecified
6.6
7.1
17
26
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.9
7.1
94
522
L04AD02
ATC
tacrolimus; systemic
6.1
7.1
18
30
M45
ICD-10 Finland
Ankylosing spondylitis
3.2
7.0
27
86
N02AX02
ATC
tramadol; systemic, rectal
1.4
7.0
499
4048
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
7.0
242
1722
C09AA01
ATC
captopril; oral
2.5
7.0
43
177
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.6
6.9
161
1047
I20.89
ICD-10 Finland
Other angina pectoris unspecified coronary artery status
2.0
6.9
70
355
A03FA02
ATC
cisapride; oral, rectal
1.8
6.8
108
634
J01AA02
ATC
doxycycline; systemic
1.4
6.8
893
7967
A10AC01
ATC
insulin (human); parenteral
1.7
6.8
119
719
5312
FHL
Bypass surgery for two vessels
9.4
6.8
13
14
AP3
HP
Catheterization of the right and left side of the heart
9.4
6.8
13
14
K25.9
ICD-10 Finland
Gastric ulcer, Unspecified as acute or chronic, without haemorrhage or perforation
2.9
6.8
30
104
I47.2
ICD-10 Finland
Ventricular tachycardia
2.8
6.7
33
121
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
1.9
6.7
77
408
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.1
6.7
62
304
TPH07
NOMESCO Finland
Cathetrisation of artery
1.6
6.7
142
903
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
6.7
198
1362
A11CC03
ATC
alfacalcidol; systemic
2.6
6.7
37
145
N18.8
ICD-10 Finland
Other chronic renal failure
2.5
6.6
41
169
A02BC03
ATC
lansoprazole; oral
1.4
6.6
345
2652
A02BC01
ATC
omeprazole; systemic
1.4
6.6
339
2600
FL1AC
NOMESCO Finland
Left cardioangiography
2.9
6.6
30
106
Z94.1
ICD-10 Finland
Heart transplant status
10.1
6.5
12
12
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
2.9
6.5
29
101
M01CB01
ATC
sodium aurothiomalate; parenteral
3.7
6.5
20
55
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
4.0
6.4
18
46
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
3.2
6.4
24
75
B03XA01
ATC
erythropoietin; parenteral
3.4
6.4
22
65
N05CD07
ATC
temazepam; oral
1.5
6.4
189
1298
D59.4
ICD-10 Finland
Other nonautoimmune haemolytic anaemias
70.2
6.4
7
*
J01MA02
ATC
ciprofloxacin; systemic
1.4
6.4
475
3864
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.1
6.4
26
86
J01DA09
ATC
[U] cefadroxil
1.4
6.4
284
2121
H53.1
ICD-10 Finland
Subjective visual disturbances
1.9
6.3
75
402
PD5BD
NOMESCO Finland
Extensive CT of aorta
2.9
6.3
28
97
I97.0
ICD-10 Finland
Postcardiotomy syndrome
8.2
6.3
13
16
Q21.10
ICD-10 Finland
Persistent ostium secundum
8.2
6.3
13
16
I49.5
ICD-10 Finland
Sick sinus syndrome
2.0
6.3
71
374
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.0
6.3
69
360
C08CA05
ATC
nifedipine; systemic
1.8
6.3
99
580
TFP00
NOMESCO Finland
Temporary use of transvenous or epicardial pacemaker
3.2
6.3
24
76
K80
ICPC
Cardiac arrhythmia NOS
1.8
6.3
97
565
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
1.8
6.3
96
558
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.5
6.3
240
1740
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
1.7
6.3
112
681
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.0
6.3
65
333
42401
ICD-8 Finland
Chronic disease of endocardium, Mitralis, operata
+∞
6.3
6
*
39602
ICD-8 Finland
Diseases of mitral and aortic valves, Aortae operata
+∞
6.3
6
*
I02.0
ICD-10 Finland
Rheumatic chorea with heart involvement
+∞
6.3
6
*
UJF32
NOMESCO Finland
Coloscopy
1.4
6.2
298
2255
ZXE40
NOMESCO Finland
More than seven and less than nine hours
2.7
6.1
31
116
C09AA04
ATC
perindopril; oral
1.9
6.1
71
379
WX892
NOMESCO Finland
Monitored bed care
1.8
6.1
95
556
R42
ICD-10 Finland
Dizziness and giddiness
1.4
6.1
289
2182
42799
ICD-8 Finland
Symptomatic heart disease, Other and unspecified disorders or heart rhythm
10.1
6.0
11
11
I38
ICD-10 Finland
Endocarditis, valve unspecified
10.1
6.0
11
11
46100
ICD-8 Finland
Acute sinusitis, Maxillaris
3.2
6.0
23
73
M02.9
ICD-10 Finland
Reactive arthropathy, unspecified
3.5
6.0
20
58
TFN04, ,
NOMESCO Finland
5.2
6.0
17
33
40299
ICD-8 Finland
Hypertensive heart disease
3.3
6.0
22
68
R03BA05
ATC
fluticasone; inhalant
1.5
6.0
192
1342
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
102
397
2.70
18.25
4.9
2.6
0.32
0.37
iu/ml
0.90
65
217
515
3670
1.67
17.03
5.4
3.4
2512.75
1906.42
ng/l
1.61
472
3185
290
1898
1.68
12.62
4.4
2.5
11.55
12.16
umol/l
0.94
266
1759
174
994
1.87
12.07
13.3
6.7
12.86
11.36
mmol/l
1.49
161
952
112
560
2.09
11.38
2.4
1.8
1.36
1.54
g/l
1.05
81
495
268
1762
1.66
11.34
4.6
2.5
2.30
2.26
g/l
0.64
248
1629
253
1645
1.67
11.16
4.7
2.5
20.97
21.77
%
0.44
238
1535
209
1305
1.72
10.69
5.0
4.1
283.32
256.15
u/l
1.16
203
1235
168
987
1.81
10.60
3.5
3.3
304.10
253.12
ng/l
0.63
154
903
642
5181
1.48
10.55
64.2
18.5
1.83
1.35
inr
36.64
559
4369
45
152
3.03
10.49
5.7
5.5
11.47
12.65
mg/l
0.90
40
140
168
1005
1.77
9.96
2.4
2.5
11.66
6.65
ug/l
1.05
149
861
72
336
2.21
8.74
2.6
3.5
0.86
0.84
nmol/l
0.14
55
278
216
1462
1.57
7.90
10.6
5.4
1.08
1.04
mmol/l
1.31
196
1335
200
1341
1.58
7.61
10.7
7.1
0.93
1.09
mmol/l
0.23
159
1080
199
1359
1.55
6.96
10.7
7.1
5.21
5.10
kpa
0.85
187
1295
199
1360
1.55
6.94
10.7
7.0
12.05
11.69
kpa
0.34
187
1299
181
1212
1.57
6.90
11.2
7.3
95.38
95.10
%
0.27
173
1169
58
281
2.11
6.47
2.6
2.6
3.82
3.62
g/l
0.45
58
269
156
1037
1.57
6.13
12.4
7.1
1.36
1.40
mmol/l
0.16
151
1014
114
704
1.68
6.03
14.2
9.1
24.35
24.40
mmol/l
0.05
107
681
10
9
11.19
5.80
4.0
5.0
—
—
—
0
0
41
183
2.28
5.62
8.9
6.0
271.50
361.20
iu/ml
—
10
25
129
839
1.60
5.57
2.0
1.7
—
—
—
0
0
901
9776
0.74
5.53
45.9
27.9
129.56
132.51
g/l
6.19
889
9621
117
745
1.63
5.50
14.0
8.9
1.32
1.32
%
0.03
117
738
901
9773
0.74
5.48
45.5
27.6
4.35
4.40
e12/l
2.00
882
9505
901
9773
0.74
5.48
46.7
28.2
38.99
39.52
%
2.10
889
9609
901
9772
0.74
5.47
45.5
27.7
231.22
242.38
e9/l
5.11
881
9534
18
52
3.50
5.46
2.9
2.0
374.46
619.56
e6/l
0.72
13
43
901
9770
0.74
5.44
45.3
27.6
91.20
91.51
fl
1.07
889
9613
113
718
1.63
5.37
14.4
9.2
0.61
0.65
%
0.44
113
712
58
303
1.96
5.33
2.2
1.6
—
—
—
0
0
70
391
1.84
5.26
4.2
4.5
25.32
25.00
mmol/l
0.56
61
361
35
151
2.35
5.20
3.9
2.6
—
630.50
—
0
12
109
692
1.63
5.20
13.8
8.3
24.77
24.87
mmol/l
0.09
109
687
371
2994
1.34
5.03
3.2
2.3
3.33
3.00
mg/l
1.71
334
2551
154
1068
1.50
4.99
3.6
2.5
70.32
68.86
e9/l
0.19
116
795
35
155
2.29
4.92
1.3
1.3
—
—
—
0
0
101
640
1.63
4.86
4.1
3.9
1.81
2.03
mmol/l
0.29
73
467
39
183
2.17
4.79
2.2
1.8
—
—
—
0
0
50
262
1.94
4.59
1.2
1.3
—
—
—
0
0
50
262
1.94
4.59
1.2
1.3
—
—
—
0
0
16
49
3.29
4.47
1.7
2.0
—
—
—
0
0
53
286
1.89
4.47
2.2
1.5
—
—
—
0
0
124
848
1.51
4.31
6.0
3.7
135.07
93.45
ng/l
1.85
109
731
204
1535
1.39
4.28
1.8
1.9
—
—
—
0
0
260
2036
1.35
4.25
2.1
2.0
—
—
—
0
0
229
1759
1.37
4.23
4.9
3.2
0.83
0.82
mmol/l
0.90
220
1643
896
9622
0.78
4.15
38.4
24.5
92.48
83.28
umol/l
4.38
878
9456
111
749
1.53
4.12
4.4
3.9
5.16
5.18
kpa
0.09
103
718
18
63
2.88
4.07
2.3
1.7
—
—
—
0
0
102
679
1.55
4.03
6.4
3.3
23.80
24.15
mmol/l
0.53
97
671
51
283
1.84
3.98
1.7
1.4
—
—
—
0
0
92
602
1.57
3.92
1.6
1.5
—
—
—
0
0
314
2557
1.30
3.87
4.1
2.9
385.88
357.06
umol/l
3.83
266
2193
489
4209
1.26
3.86
6.2
4.3
48.28
74.69
ng/l
0.79
387
3206
192
1456
1.37
3.84
1.9
1.9
—
—
—
0
0
47
263
1.82
3.60
1.4
1.5
—
—
—
0
0
881
9430
0.79
3.59
17.0
12.2
24.90
25.36
u/l
0.34
854
9092
303
2482
1.29
3.54
3.5
2.5
—
—
—
0
0
14
47
3.00
3.41
1.6
3.6
99.50
96.00
%
0.15
14
47
543
4777
1.24
3.41
11.6
6.4
1.20
1.21
mmol/l
2.24
504
4364
108
758
1.46
3.35
3.4
2.9
59.79
61.55
ml/min/173m2
0.17
58
336
64
402
1.62
3.27
6.4
3.5
62.55
64.41
mg/l
0.04
53
345
64
403
1.62
3.24
6.3
3.6
44.52
57.52
mg/l
0.53
53
348
155
1169
1.37
3.21
6.8
3.4
1.20
1.91
mmol/l
1.70
136
973
614
5501
1.22
3.16
12.5
8.9
4.43
4.28
e9/l
0.77
534
4751
47
276
1.73
3.10
2.0
1.6
—
—
—
0
0
675
7380
0.82
3.08
41.1
24.1
329.34
331.37
g/l
6.48
668
7319
16
62
2.60
3.05
5.3
3.6
1.00
0.89
index
0.21
16
62
64
410
1.59
3.04
1.4
1.3
—
—
—
0
0
7
12
5.86
3.02
1.1
1.1
93.14
89.75
%
—
7
12
156
1195
1.35
2.94
2.5
2.8
9.33
9.30
umol/l
0.01
132
1048
883
9380
0.81
2.90
37.5
22.8
4.02
4.00
mmol/l
1.13
865
9146
305
2560
1.25
2.87
5.6
4.2
72.43
85.17
%
9.44
300
2511
45
269
1.70
2.81
2.1
1.6
—
—
—
0
0
505
4476
1.21
2.80
4.8
3.0
159.97
137.56
ug/l
0.54
474
4101
883
9368
0.82
2.79
37.0
22.6
139.36
139.57
mmol/l
1.55
866
9149
131
985
1.37
2.79
4.0
2.8
65.29
66.20
g/l
0.65
123
895
25
124
2.04
2.77
1.6
1.8
89.14
89.88
%
0.25
25
124
29
152
1.93
2.76
1.7
1.2
224.90
284.30
u/ml
0.60
20
82
7
14
5.02
2.73
5.6
8.0
4.89
4.94
kpa
—
7
14
155
1201
1.33
2.72
6.9
3.4
5.90
5.81
kpa
0.52
148
1165
12
40
3.02
2.69
3.2
1.8
—
—
—
0
0
12
40
3.02
2.69
3.2
1.8
—
—
—
0
0
808
8634
0.83
2.69
5.6
5.3
6.09
6.04
mmol/l
0.43
739
7746
57
367
1.58
2.68
6.4
3.4
11.93
2.32
ratio
0.60
31
220
592
5343
1.20
2.68
7.8
6.4
13.40
12.33
umol/l
0.98
567
5086
12
41
2.94
2.62
3.2
1.8
—
—
—
0
0
238
2853
0.80
2.58
4.8
4.7
21.77
21.89
%
0.04
121
1471
12
44
2.74
2.55
2.1
1.2
—
—
—
0
0
12
44
2.74
2.55
2.2
2.6
618.50
811.30
u/ml
0.56
12
44
12
44
2.74
2.55
2.1
1.2
—
—
—
0
0
303
3529
0.82
2.50
5.1
5.8
2.66
4.54
ug/l
0.85
274
3136
132
1012
1.34
2.50
6.2
2.8
4.50
4.44
kpa
0.12
125
983
828
8801
0.83
2.47
6.2
5.9
2.46
2.58
mmol/l
3.66
774
8000
14
57
2.47
2.45
2.3
2.4
—
—
—
0
0
39
234
1.69
2.44
2.2
1.5
—
—
—
0
0
366
3181
1.21
2.43
2.8
2.6
58.87
86.18
u/l
0.55
343
2942
6
12
5.02
2.40
18.8
13.1
4.02
5.66
mmol/l
—
6
12
168
2081
0.78
2.39
3.2
3.4
0.78
0.82
ug/l
0.24
117
1415
48
306
1.59
2.38
1.4
1.3
—
—
—
0
0
54
355
1.54
2.36
2.1
1.8
14.43
7.40
iu/ml
0.57
12
83
797
8485
0.84
2.35
7.3
6.8
40.66
40.10
mmol/mol
0.80
747
7818
73
512
1.45
2.34
2.1
1.8
1.59
2.17
ug/l
0.32
68
435
804
8550
0.84
2.32
5.4
5.0
1.38
1.43
mmol/l
3.06
749
7749
25
133
1.90
2.32
1.7
1.6
—
—
—
0
0
6
13
4.63
2.27
2.0
1.0
—
—
—
0
0
225
1876
1.24
2.23
4.0
3.2
1.23
1.13
e6/l
0.12
122
1030
812
8615
0.85
2.22
5.4
5.1
4.30
4.47
mmol/l
4.47
761
7869
125
970
1.32
2.20
2.5
2.4
35.39
35.01
u/l
0.04
106
807
8
24
3.35
2.18
1.0
1.0
—
—
—
0
0
23
122
1.90
2.17
1.1
1.1
0.90
1.56
u/ml
0.48
15
63
86
632
1.39
2.15
5.5
2.4
1.20
1.13
%
0.34
86
627
10
36
2.79
2.14
4.2
3.4
11.63
10.35
kpa
—
10
36
10
36
2.79
2.14
4.2
3.4
4.67
4.86
kpa
—
10
36
76
548
1.41
2.12
1.4
1.2
108.06
243.52
u/ml
1.66
67
503
13
55
2.38
2.12
3.0
1.7
—
—
—
0
0
13
55
2.38
2.12
3.0
1.7
—
—
—
0
0
13
55
2.38
2.12
3.0
1.7
—
—
—
0
0
13
55
2.38
2.12
3.0
1.7
—
—
—
0
0
47
308
1.55
2.11
5.3
3.6
2.64
1.66
index
0.55
33
161
256
2178
1.22
2.10
5.7
4.3
518.36
354.73
ng/l
0.28
225
1826
136
1076
1.30
2.09
2.6
2.2
157.78
137.09
ug/g
0.29
115
855
23
124
1.87
2.07
3.9
4.0
—
—
—
0
0
19
96
1.99
2.06
3.3
2.0
—
—
—
0
0
770
8182
0.85
2.06
4.6
4.3
1.31
1.27
mmol/l
0.78
713
7336
580
5311
1.17
2.04
12.1
7.1
1.20
1.21
mmol/l
1.08
511
4543
24
133
1.82
2.00
1.4
1.6
—
—
—
0
0
27
156
1.75
1.97
1.5
1.4
12348.44
80098.41
e6/l
0.94
18
85
212
1781
1.23
1.97
1.8
1.5
2.83
2.61
g/l
0.55
123
1058
8
27
2.97
1.93
2.0
2.4
0.62
0.61
mmol/l
—
8
27
17
85
2.01
1.90
1.3
1.6
—
—
—
0
0
18
92
1.97
1.90
3.1
1.6
—
—
—
0
0
18
92
1.97
1.90
3.1
1.6
—
—
—
0
0
18
92
1.97
1.90
3.1
1.6
—
—
—
0
0
27
158
1.72
1.90
1.9
1.5
—
—
—
0
0
43
285
1.53
1.86
1.6
1.5
0.01
22.51
iu/ml
—
9
54
11
46
2.40
1.85
1.1
1.3
—
—
—
0
0
38
246
1.56
1.83
1.4
1.3
—
—
—
0
0
25
145
1.74
1.82
2.1
1.4
187.49
166.86
au/ml
—
7
39
31
192
1.63
1.79
1.8
1.4
—
—
—
0
0
100
777
1.31
1.78
1.8
1.7
—
—
—
0
0
648
6029
1.15
1.75
8.5
5.1
6.80
6.80
mmol/l
0.00
615
5742
33
209
1.59
1.75
1.5
1.5
30.28
30.59
g/l
0.06
26
192
290
2540
1.18
1.73
3.7
2.8
6.10
5.46
e6/l
0.37
266
2322
31
194
1.61
1.72
1.7
1.5
—
—
—
0
0
21
118
1.79
1.70
2.7
2.7
28.83
20.33
mg/l
—
6
50
696
7397
0.87
1.68
38.1
22.8
14.35
13.85
%
10.65
688
7292
41
276
1.50
1.68
1.8
1.6
20922.80
15401.05
e6/l
0.38
35
191
19
105
1.82
1.63
3.3
1.9
—
—
—
0
0
71
933
0.75
1.61
1.9
1.7
1.59
1.50
%
0.57
64
795
247
2149
1.18
1.60
1.9
1.8
1315.86
1182.05
nmol/l
1.21
193
1594
343
3068
1.16
1.57
4.8
3.5
0.64
0.49
e6/l
0.61
273
2333
13
64
2.04
1.54
1.8
1.4
—
—
—
0
0
13
64
2.04
1.54
1.8
1.4
—
—
—
0
0
18
100
1.81
1.53
2.0
1.6
60.23
64.74
%
0.20
13
72
28
177
1.59
1.52
1.6
1.4
1397.21
1328.49
e6/l
0.05
19
119
7
27
2.60
1.51
2.0
1.2
—
—
—
0
0
34
227
1.51
1.47
1.7
1.4
—
—
—
0
0
204
1762
1.19
1.44
4.3
3.3
2.49
2.17
e6/l
0.24
99
915
798
8363
0.88
1.44
5.7
5.3
2.02
1.99
mu/l
0.28
739
7597
44
313
1.42
1.40
3.5
3.2
3.84
3.96
mmol/l
1.00
44
307
10
46
2.18
1.40
1.0
1.0
—
—
—
0
0
9
41
2.20
1.37
2.2
1.7
40.90
38.78
g/l
—
9
41
22
135
1.64
1.36
1.5
1.4
—
—
—
0
0
11
209
0.52
1.35
1.1
1.2
1.46
1.53
g/l
1.06
11
209
27
175
1.55
1.35
2.1
2.2
417.11
4960.85
u/l
—
8
66
42
299
1.42
1.34
1.5
1.4
282.60
274.54
ug/g
0.10
28
178
878
9129
0.88
1.34
31.1
18.6
25.63
27.19
mg/l
0.71
793
7734
12
221
0.54
1.34
1.2
1.2
0.92
0.92
g/l
0.04
12
221
13
68
1.92
1.33
1.4
1.6
13.33
14.41
umol/l
0.17
13
63
22
136
1.63
1.33
1.5
1.4
—
—
—
0
0
369
3360
1.14
1.30
4.4
4.1
15.13
9.42
mg/mmol
1.07
252
2158
22
137
1.62
1.30
1.5
1.4
—
—
—
0
0
356
3238
1.14
1.27
2.9
2.2
165.22
243.37
u/l
1.90
343
3049
820
8549
0.89
1.26
28.0
18.3
72.62
75.00
ml/min/173m2
2.04
777
7961
56
424
1.34
1.26
2.9
2.7
0.24
1.19
g/l
3.82
51
363
35
492
0.70
1.26
1.4
1.8
3.52
3.46
mmol/l
0.09
25
371
55
418
1.33
1.21
3.3
2.8
—
—
—
0
0
16
93
1.73
1.21
1.4
1.6
—
—
—
0
0
389
3569
1.13
1.21
4.9
3.6
115.49
94.20
e6/l
0.11
312
2800
21
132
1.60
1.20
1.6
1.4
—
—
—
0
0
21
132
1.60
1.20
1.6
1.4
—
—
—
0
0
15
250
0.60
1.19
1.3
1.3
—
—
—
0
0
120
1007
1.21
1.18
2.5
2.2
0.20
0.20
g/l
0.19
107
921
21
133
1.59
1.17
1.6
1.4
—
—
—
0
0
370
3390
1.13
1.17
4.0
3.4
6.93
7.40
mmol/l
1.39
304
2823
662
6969
0.90
1.17
4.6
4.2
15.14
14.97
pmol/l
1.04
606
6275
5
20
2.51
1.15
1.0
1.5
—
—
—
0
0
8
40
2.01
1.12
2.6
1.2
—
—
—
0
0
17
105
1.63
1.06
2.6
2.4
-1.32
0.50
mmol/l
1.35
17
100
61
766
0.79
1.05
2.1
2.4
14.19
12.88
nmol/l
0.61
54
679
14
226
0.62
1.01
1.7
1.7
369.43
296.63
mu/l
0.32
14
208
12
68
1.77
1.00
2.1
1.3
—
—
—
0
0
12
68
1.77
1.00
2.1
1.3
—
—
—
0
0
7
35
2.01
1.00
1.7
1.4
—
—
—
0
0
132
1140
1.18
0.98
5.2
5.0
31.29
32.59
%
0.72
101
706
52
656
0.78
0.95
1.5
2.0
3.78
3.52
ratio
0.65
43
537
0
32
0.00
0.95
0.0
1.6
—
7.28
—
0
32
55
436
1.27
0.94
2.5
1.9
—
—
—
0
0
72
873
0.81
0.93
10.1
3.8
1.21
1.23
mmol/l
0.73
64
746
163
1440
1.15
0.91
1.4
1.3
9.07
11.88
u/ml
0.28
51
529
17
110
1.55
0.90
1.2
1.5
—
—
—
0
0
85
714
1.20
0.88
1.3
1.4
—
—
—
0
0
37
281
1.33
0.87
1.3
1.2
—
—
—
0
0
503
4753
1.10
0.87
6.7
5.0
34.38
34.83
g/l
1.01
467
4415
8
44
1.82
0.86
1.3
1.2
141.28
178.68
pmol/l
—
8
44
37
282
1.32
0.86
1.3
1.2
—
—
—
0
0
220
1996
1.12
0.83
1.3
1.3
1.00
1.46
u/ml
0.58
48
525
26
188
1.39
0.83
8.2
3.2
16.37
9.80
pmol/l
0.96
26
188
10
58
1.73
0.79
1.6
1.6
—
—
—
0
0
421
3961
1.09
0.79
5.9
4.2
160.06
132.93
e6/l
0.20
319
2904
208
2286
0.89
0.79
2.7
3.0
2.46
2.46
mmol/l
0.22
169
2028
15
223
0.67
0.79
2.8
1.8
3.81
30.31
iu/l
—
6
89
13
199
0.65
0.78
1.8
2.1
241.00
217.33
pmol/l
0.31
13
186
561
5873
0.92
0.77
3.8
3.3
64.89
53.14
u/l
1.55
518
5444
41
324
1.27
0.75
1.3
1.2
0.32
1.36
u/ml
—
5
23
11
67
1.65
0.75
1.6
1.5
—
—
—
0
0
13
83
1.57
0.75
1.2
1.1
—
70.43
—
0
7
478
4537
1.09
0.73
3.8
2.9
—
—
estimate
—
0
0
15
100
1.51
0.73
1.1
1.0
1.56
2.24
u/ml
—
9
51
49
398
1.24
0.72
1.9
1.8
—
—
—
0
0
9
56
1.61
0.72
1.7
1.6
—
—
—
0
0
42
521
0.80
0.71
1.2
1.2
44.04
138.77
u/ml
2.24
16
202
16
110
1.46
0.68
1.7
2.2
3.50
1.54
u/field
—
8
54
172
1561
1.12
0.67
1.4
1.3
35.28
33.64
iu/ml
0.07
48
474
105
923
1.15
0.67
1.8
1.9
357.32
382.26
nmol/l
0.80
97
853
5
94
0.53
0.66
1.2
1.3
—
—
—
0
0
18
129
1.40
0.63
1.3
1.3
—
0.70
nmol/l
—
0
6
29
225
1.30
0.63
6.3
4.3
5.07
5.06
kpa
0.02
29
220
8
50
1.60
0.61
1.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.4
—
—
—
0
0
141
1277
1.12
0.59
1.8
1.5
—
—
—
0
0
19
253
0.75
0.58
1.6
1.9
43.53
40.71
nmol/l
0.14
19
238
6
35
1.72
0.57
1.2
1.1
1.01
1.07
ratio
—
6
29
6
37
1.62
0.55
1.5
1.2
—
—
—
0
0
13
90
1.45
0.55
1.0
1.2
—
—
—
0
0
13
90
1.45
0.55
1.9
1.3
—
—
—
0
0
9
60
1.50
0.54
2.6
1.8
333.00
94.65
ng/l
—
9
60
11
74
1.49
0.53
1.0
1.1
0.16
0.92
u/ml
—
6
22
102
1137
0.89
0.53
3.4
4.1
5.64
25.62
ug/l
1.87
85
960
9
62
1.45
0.53
1.3
1.2
—
—
—
0
0
9
64
1.41
0.51
1.3
1.2
—
—
—
0
0
9
64
1.41
0.51
1.3
1.2
—
—
—
0
0
9
64
1.41
0.51
1.3
1.2
—
—
—
0
0
47
398
1.19
0.51
1.1
1.1
—
—
—
0
0
533
5139
1.06
0.50
5.3
4.2
0.00
0.00
estimate
-0.00
114
1137
483
5019
0.94
0.50
2.9
2.8
—
—
—
0
0
47
399
1.18
0.50
1.4
1.3
—
—
—
0
0
33
272
1.22
0.47
2.0
2.1
—
—
—
0
0
310
2943
1.07
0.47
5.6
4.3
0.00
0.01
estimate
0.96
95
1008
29
236
1.23
0.47
3.0
2.3
184.78
92.91
ug/min
0.55
18
142
538
5199
1.06
0.47
5.3
4.3
12.91
4.19
estimate
0.29
114
1173
24
191
1.26
0.46
1.7
1.5
—
—
—
0
0
281
2667
1.07
0.43
3.8
3.4
0.27
0.08
0.31
11
103
8
112
0.71
0.37
1.3
1.5
—
—
—
0
0
5
37
1.35
0.37
1.4
1.2
—
—
—
0
0
13
169
0.77
0.37
1.5
1.4
—
—
—
0
0
15
191
0.78
0.37
1.2
1.2
4.16
3.77
mmol/l
0.46
15
179
9
70
1.29
0.36
1.3
1.2
—
—
—
0
0
328
3150
1.06
0.35
3.7
3.2
36.10
35.90
u/l
0.02
311
2974
6
43
1.40
0.35
1.2
1.1
—
—
—
0
0
6
90
0.67
0.32
1.2
1.4
—
318.00
—
0
10
68
617
1.11
0.32
2.0
1.9
—
—
—
0
0
10
74
1.35
0.32
1.0
1.1
114.10
98.05
pmol/l
—
10
74
38
332
1.15
0.32
2.1
2.1
—
—
—
0
0
11
83
1.33
0.32
1.2
2.6
8.29
8.31
mmol/l
0.01
11
83
537
5235
1.04
0.32
5.3
4.3
0.00
0.28
estimate
0.52
104
1110
7
53
1.32
0.31
2.1
3.1
0.43
0.92
%
—
7
53
29
250
1.16
0.29
1.2
1.2
—
30.17
—
0
11
74
679
1.10
0.29
2.0
2.0
—
—
—
0
0
7
56
1.25
0.29
3.6
4.3
—
—
—
0
0
7
56
1.25
0.29
2.0
1.2
—
—
—
0
0
27
232
1.17
0.28
4.1
4.0
24.39
28.69
mg/l
0.29
22
178
711
6986
1.04
0.28
6.3
4.3
15.66
14.04
mm/h
1.70
665
6432
8
62
1.29
0.28
1.8
1.2
—
—
—
0
0
18
149
1.21
0.28
1.6
1.6
—
—
—
0
0
8
63
1.27
0.27
1.8
1.2
—
—
—
0
0
9
117
0.77
0.27
1.1
1.1
—
—
—
0
0
39
436
0.89
0.26
1.9
3.3
30.62
9340.31
u/ml
0.86
30
378
5
73
0.68
0.26
1.4
1.4
—
—
—
0
0
6
85
0.70
0.24
1.2
1.4
—
56.25
—
0
8
5
42
1.19
0.21
1.2
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
5
43
1.16
0.21
4.8
6.9
—
81.20
—
0
10
0
13
0.00
0.21
0.0
1.2
—
18.05
—
0
8
753
7434
1.03
0.20
11.1
8.1
83.39
81.60
u/l
0.39
716
6980
14
117
1.20
0.20
1.6
1.2
2.67
4.61
u/ml
—
9
41
10
80
1.25
0.20
1.3
1.2
—
—
—
0
0
312
3204
0.97
0.20
2.0
1.8
19.92
20.05
nmol/l
0.05
275
2687
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
19
218
0.87
0.19
1.3
1.3
401.00
490.86
mg/l
0.71
19
207
11
133
0.83
0.19
1.5
1.5
—
—
—
0
0
121
1155
1.05
0.19
12.3
8.6
—
—
—
0
0
7
61
1.15
0.17
2.3
2.3
—
—
—
0
0
8
71
1.13
0.16
1.0
1.1
—
—
—
0
0
32
349
0.91
0.16
1.1
1.5
0.30
0.34
mg/l
0.18
15
156
6
79
0.76
0.15
1.7
1.7
—
—
—
0
0
237
2310
1.03
0.15
5.8
4.5
1.02
1.02
kg/l
1.73
170
1549
30
274
1.10
0.15
2.6
2.2
125.38
126.45
g/l
0.08
21
215
18
203
0.89
0.15
1.3
1.3
213.48
247.26
miu/ml
—
8
91
21
188
1.12
0.14
1.1
1.3
—
316.84
—
0
19
7
86
0.81
0.14
1.9
1.6
—
—
—
0
0
8
99
0.81
0.13
1.3
1.5
—
22.60
—
0
15
9
107
0.84
0.13
1.2
1.2
111.00
114.47
%
—
9
99
219
2141
1.03
0.12
2.1
1.7
1.17
1.45
mg/l
1.11
164
1695
117
1132
1.04
0.12
4.8
3.7
—
—
—
0
0
103
995
1.04
0.11
1.5
1.4
—
—
—
0
0
30
279
1.08
0.11
1.7
1.6
—
—
—
0
0
271
2757
0.98
0.10
4.6
3.8
0.02
0.05
estimate
0.35
87
876
370
3650
1.02
0.10
3.3
3.3
2.35
2.35
mmol/l
0.23
319
3263
40
379
1.06
0.09
1.8
2.1
39.48
39.11
u/l
0.04
33
332
465
4699
0.98
0.09
2.5
2.3
94.64
93.58
pmol/l
0.19
250
2471
5
64
0.78
0.08
1.0
1.9
114.20
92.47
umol/l
—
5
64
6
71
0.84
0.07
1.0
1.2
—
—
—
0
0
226
2292
0.98
0.07
1.9
1.8
47692753.96
14739548.16
pmol/l
0.30
195
1859
13
118
1.10
0.07
1.0
1.0
—
—
—
0
0
13
141
0.92
0.05
1.1
1.1
—
—
—
0
0
670
6670
1.01
0.05
6.7
5.3
729.00
2653.90
e6/l
1.27
13
115
393
3905
1.01
0.04
5.4
4.3
0.01
0.07
estimate
1.39
97
950
435
4325
1.01
0.04
3.0
2.4
81.04
78.23
nmol/l
1.14
396
3815
356
3546
1.01
0.02
2.0
1.9
1.34
1.32
mmol/l
0.10
298
2948
57
561
1.02
0.02
2.3
2.5
15.86
17.40
au/ml
—
7
41
26
267
0.97
0.01
1.7
1.8
6.60
4.05
mg/l
0.45
19
208
12
122
0.98
0.00
1.7
1.2
6.71
5.34
u/ml
—
7
58
23
228
1.01
0.00
1.5
1.3
—
—
—
0
0
11
111
0.99
0.00
2.9
2.5
—
—
—
0
0
31
305
1.02
0.00
1.6
1.6
50.86
15.68
u/ml
—
8
60
21
205
1.02
0.00
2.0
1.5
11.72
9.89
u/l
0.28
16
157
0
5
0.00
0.00
0.0
1.6
—
465.60
—
0
5
0
5
0.00
0.00
0.0
1.8
—
30.20
—
0
5
0
5
0.00
0.00
0.0
1.6
—
2.60
—
0
5
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
8
87
0.92
-0.00
1.1
1.2
94.37
98.83
%
—
8
81
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
74
0.95
-0.00
3.7
2.3
18.86
35.57
mg/l
—
7
56
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
83
0.96
-0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
80
1.00
-0.00
1.0
1.1
—
—
—
0
0
5
59
0.85
-0.00
1.2
2.5
23.00
19.66
nmol/l
—
5
53
0
7
0.00
-0.00
0.0
1.4
—
6.11
—
0
7
0
6
0.00
-0.00
0.0
6.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint I9_RHEUFEV and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_RHEUFEV | 2.108 [1.91, 2.33] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.153 |
During the follow-up period (1.1.1998 — 31.12.2019), 1814 out of 3349 females with I9_RHEUFEV died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_RHEUFEV | 1.918 [1.69, 2.18] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1381 out of 2720 males with I9_RHEUFEV died.
Mortality risk
Mortality risk for people of age
years, who have I9_RHEUFEV.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.123% | 0.234% |
| 5 | 0.939% | 1.818% |
| 10 | 2.767% | 4.92% |
| 15 | 5.439% | 8.981% |
| 20 | 9.551% | 15.703% |
Relationships between endpoints
↥Index endpoint: I9_RHEUFEV – Rheumatic fever incl heart disease
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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