Rheumatic fever with heart involvement

I9_RHEUFEVHRT

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — I01, I02.0 Hospital discharge: ICD-9 — 391 Hospital discharge: ICD-8 — 391 Cause of death: ICD-10 — I01, I02.0 Cause of death: ICD-9 — 391 Cause of death: ICD-8 — 391 2 out of 7 registries used, show all original rules.	208
4. Check minimum number of events None	208
5. Include endpoints None	208
6. Filter based on genotype QC (FinnGen only)	178

Control definitions (FinnGen only)

Control exclude: I9_RHEUFEV

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	I9_RHEUFEVHRT
CONTROL_EXCLUDE	I9_RHEUFEV
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	I01\|I020
HD_ICD_9	391
HD_ICD_8	391
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	I01\|I020
COD_ICD_9	391
COD_ICD_8	391
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Rheumatic fever with heart involvement based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1875	843	1004
Only index persons	1312	610	702
Unadjusted period prevalence (%)
Whole population	0.03	0.02	0.03
Only index persons	0.02	0.02	0.03
Median age at first event (years)
Whole population	45.88	50.55	41.60
Only index persons	36.70	41.53	32.50

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	178	87	91
Unadjusted period prevalence (%)	0.04	0.03	0.04
Median age at first event (years)	44.67	45.90	43.50

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
180: Matched controls
1800

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

I01.0

ICD-10 Finland

Acute rheumatic pericarditis

+∞

76.7

39199

ICD-8 Finland

Rheumatic fever with heart involvement, Other active rheumatic heart disease

+∞

24.5

39197

ICD-8 Finland

Rheumatic fever with heart involvement, Suspecta

+∞

23.4

I01.9

ICD-10 Finland

Acute rheumatic heart disease, unspecified

+∞

14.8

I01.1

ICD-10 Finland

Acute rheumatic endocarditis

+∞

10.5

I01.8

ICD-10 Finland

Other acute rheumatic heart disease

+∞

9.5

TDM10

NOMESCO Finland

Puncture of maxillary antrum

8.6

3910A

ICD-9 Finland

Rheumatic fever with heart involvement, Acute rheumatic pericarditis

+∞

8.4

J46

ICD-10 Finland

Status asthmaticus

8.8

8.3

R50.9

ICD-10 Finland

Fever, unspecified

3.0

8.1

166

DM1QA

NOMESCO Finland

Paranasal sinuses X-ray examination in one projection

6.5

8.0

J01.0

ICD-10 Finland

Acute maxillary sinusitis

2.6

7.3

270

L01BA01

ATC

methotrexate; systemic

7.7

6.9

UJF32

NOMESCO Finland

Coloscopy

2.4

6.6

304

Z04.8

ICD-10 Finland

Examination and observation for other specified reasons

3.0

6.5

122

I02.0

ICD-10 Finland

Rheumatic chorea with heart involvement

+∞

6.3

J32.0

ICD-10 Finland

Chronic maxillary sinusitis

3.5

6.2

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

4.4

6.2

H02AB06

ATC

prednisolone; systemic

2.2

6.0

641

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

126

2.98

6.68

2.3

1.5

—

(3000570) Elastase.pancreatic [Mass/mass] in Stool

3.99

5.50

1.6

1.3

322.77

308.09

ug/g

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.54

5.48

1.8

1.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

168

2.51

5.34

4.0

1.8

—

(3023368) Bacteria identified in Blood by Culture

446

1.93

4.24

8.3

4.3

—

(3000991) Gas panel - Venous blood

131

2.45

4.20

13.0

8.1

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

700

1.84

3.90

15.4

6.1

1.21

mmol/l

0.37

647

(3018677) aPTT in Platelet poor plasma by Coagulation assay

230

2.08

3.86

3.6

1.9

29.87

28.96

0.52

222

(3001467) Alkaline phosphatase.bone [Enzymatic activity/volume] in Serum or Plasma

10.28

3.52

1.5

1.7

43.00

51.33

u/l

—

(3025941) Bacteria identified in Stool by Culture

2.68

3.51

1.5

1.3

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

197

2.03

3.29

7.3

4.4

234.75

232.26

u/l

0.06

185

(3018418) pH of Serum or Plasma

485

1.77

3.29

11.4

4.3

7.40

0.49

354

(3015736) pH of Urine

642

1.73

3.21

4.3

3.7

6.57

6.23

1.63

367

(3048689) Calprotectin [Mass/mass] in Stool

192

2.02

3.17

3.5

2.4

286.43

130.65

ug/g

0.84

157

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

101

767

1.72

3.17

16.2

7.2

1.20

1.21

mmol/l

0.33

664

(40758558) Short blood count panel - Blood

458

1.74

3.05

12.6

6.3

—

(3045684) Alkaline phosphatase.other fractions [Enzymatic activity/volume] in Serum or Plasma

10.23

2.99

1.6

22.20

21.00

u/l

—

(3035400) Alkaline phosphatase.liver [Enzymatic activity/volume] in Serum or Plasma

10.23

2.99

1.6

65.60

72.80

u/l

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.59

2.95

1.3

1.1

—

(3035715) Granulocytes [#/volume] in Blood

4.25

2.92

4.2

2.1

3.74

4.53

e9/l

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

5.55

2.90

1.4

1.8

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

223

1.89

2.84

17.7

5.3

1.09

1.04

mmol/l

0.62

208

(42870588) Differential panel, method unspecified - Blood

497

1.67

2.72

10.9

5.6

—

(3035350) Ketones [Presence] in Urine by Test strip

104

819

1.64

2.67

5.0

4.1

73.60

8.92

estimate

0.40

182

(3019198) Lymphocytes [#/volume] in Blood

100

782

1.63

2.62

13.0

5.9

1.74

1.93

e9/l

0.88

686

(3014576) Chloride [Moles/volume] in Serum or Plasma

221

1.85

2.61

10.4

6.5

104.86

104.26

mmol/l

0.31

221

(3001604) Monocytes [#/volume] in Blood

764

1.62

2.59

13.1

5.8

0.60

0.58

e9/l

0.25

642

(3006315) Basophils [#/volume] in Blood

766

1.61

2.55

13.1

5.8

0.04

e9/l

0.04

642

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.67

2.50

1.5

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.67

2.50

1.5

1.2

—

(42529406) Shigella sp [Presence] in Stool by Culture

2.67

2.50

1.5

1.2

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

3.94

2.49

1.6

1.3

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

654

1.60

2.49

3.5

2.7

76.17

77.39

nmol/l

0.17

586

(3013115) Eosinophils [#/volume] in Blood

100

789

1.60

2.48

13.7

6.1

0.19

0.20

e9/l

0.10

678

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

5.13

2.42

1.0

—

(3021601) Nitrite [Presence] in Urine by Test strip

102

812

1.59

2.41

4.7

4.0

0.00

estimate

-0.00

176

(3021788) Differential panel - Synovial fluid

3.75

2.39

1.5

1.1

—

(3026008) Bacteria identified in Urine by Culture

478

1.60

2.30

4.2

3.4

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

105

850

1.56

2.25

18.3

10.0

4.36

4.15

e9/l

0.35

736

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

259

1.70

2.15

3.6

1.9

—

(3009261) Glucose [Presence] in Urine by Test strip

102

826

1.54

2.14

4.8

4.1

0.00

estimate

-0.00

165

(3035933) Granulocytes/Leukocytes in Blood

3.00

2.10

4.2

2.5

57.11

59.59

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

141

1.90

2.10

1.7

2.2

350.56

366.84

nmol/l

0.18

129

(3029634) Reagin Ab [Titer] in Serum by VDRL

4.10

2.05

3.3

1.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

198

1.75

2.01

2.6

1.8

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

3.42

1.98

1.4

1.8

0.23

0.16

nmol/l

—

(3026389) Candida sp identified in Specimen by Organism specific culture

3.84

1.95

1.0

1.3

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

3.84

1.95

3.2

4.1

1724.00

579.69

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

3.27

1.90

2.9

1.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

336

1.58

1.89

3.9

2.5

—

(3011648) Oxygen content in Venous blood

4.25

1.83

4.0

1.8

9.90

11.83

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

2.65

1.83

2.7

1.5

—

(3023419) Bacteria identified in Sputum by Culture

2.84

1.81

6.8

2.1

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

280

1.60

1.79

5.6

3.1

0.84

0.82

mmol/l

0.42

265

(3000494) Fungus identified in Specimen by Culture

181

1.72

1.77

2.6

1.5

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

522

1.49

1.75

5.3

3.1

2.37

2.36

mmol/l

0.30

472

(3028167) CD3+CD4+ (T4 helper) cells [#/volume] in Blood

3.92

1.72

3.0

2.3

0.63

0.42

e9/l

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

3.92

1.72

1.2

—

(3026493) Urate [Moles/volume] in Serum or Plasma

379

1.52

1.71

6.0

2.9

366.74

349.59

umol/l

0.46

326

(3042936) Bacteria identified in Isolate by Culture

233

1.62

1.69

3.8

2.0

—

(3017181) Myelocytes/Leukocytes in Blood

144

1.77

1.68

7.6

4.4

0.56

0.78

—

(3044941) Cell count panel - Synovial fluid

3.23

1.67

1.5

1.1

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.33

1.67

1.2

1.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

193

1.67

1.65

3.4

1.9

—

(3002179) Metamyelocytes/Leukocytes in Blood

137

1.78

1.65

7.1

4.5

0.63

0.61

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

2.57

1.61

2.9

1.5

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.49

1.55

1.8

1.3

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.49

1.55

1.5

1.3

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

3.40

1.53

7.0

2.1

—

(3009595) Pneumocystis jirovecii DNA [Presence] in Specimen by NAA with probe detection

3.40

1.53

1.6

1.7

—

(4062490) Immunoglobulin typing, IgG

3.40

1.53

2.0

1.5

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

3.40

1.53

1.0

1.1

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

3.40

1.53

7.0

2.1

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

3.40

1.53

7.0

2.1

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

3.40

1.53

1.0

1.2

—

(3018095) Leukocytes [#/volume] in Urine

590

1.43

1.53

5.3

4.2

116.95

102.98

e6/l

0.09

433

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

2.92

1.52

3.0

1.3

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

3.18

1.45

1.0

1.1

—

(3032080) INR in Blood by Coagulation assay

751

1.40

1.41

26.8

14.0

1.37

1.27

inr

0.74

626

(3020779) Urea [Moles/volume] in Serum or Plasma

136

1.70

1.40

22.9

6.5

10.52

10.35

mmol/l

0.04

127

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

647

1.39

1.37

5.6

4.4

40.25

38.40

ng/l

0.08

493

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

676

1.39

1.37

3.8

2.9

—

estimate

—

(3016502) Oxygen saturation in Arterial blood

178

1.61

1.36

13.2

7.1

97.22

95.36

3.28

172

(40768804) Tissue Pathology biopsy report

544

1.40

1.35

2.3

2.0

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.15

1.32

2.8

1.4

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.97

1.26

7.5

3.1

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.86

1.25

4.5

3.2

4.28

4.47

pmol/l

0.36

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

2.68

1.22

7.2

1.9

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.16

1.20

3.0

1.4

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

2.06

1.19

1.4

1.5

0.24

g/l

—

(40760892) CBC W Ordered Manual Differential panel - Blood

351

1.42

1.18

8.9

4.9

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.81

1.16

2.9

1.6

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

177

1.55

1.16

2.3

1.4

—

(3019309) Folate [Moles/volume] in Red Blood Cells

290

1.44

1.15

1.7

1529.82

1262.33

nmol/l

0.76

215

(40761535) Cells panel - Urine sediment

128

1.63

1.14

5.6

3.6

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

576

1.35

1.14

4.7

3.4

—

(3037522) Nuclear Ab [Titer] in Serum

195

1.52

1.13

1.4

1.3

272.00

596.86

titre

—

(3044640) Blood type and Crossmatch panel - Blood

474

1.36

1.12

3.8

2.5

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

2.42

1.10

1.0

1.6

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

2.42

1.10

1.0

1.6

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

2.42

1.10

1.0

1.6

—

(21494755) Public health laboratory ask at order entry panel

125

0.46

1.09

1.2

1.4

—

(3049717) Cytology report of Urine Cyto stain

1.98

1.08

1.2

2.8

—

(3002256) Pathology report gross observation

189

1.50

1.07

1.3

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

2.31

1.04

3.4

1.3

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

2.31

1.04

7.2

1.8

—

(1761868) Lipid panel - Serum or Plasma

532

0.73

1.02

3.4

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

585

1.32

1.01

1.9

2.0

1.37

1.38

mmol/l

0.05

482

(3025159) Blasts/Leukocytes in Blood

141

1.55

1.00

8.0

4.9

0.00

0.29

—

(3019150) Specific gravity of Urine by Refractometry

362

1.36

0.98

6.9

4.3

1.01

1.02

kg/l

3.01

251

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

1.84

0.98

1.4

1.5

1.24

1.10

g/l

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.67

0.97

1.4

—

(3021589) Normoblasts [#/volume] in Blood

685

1.30

0.96

22.2

12.4

0.00

e9/l

0.50

547

(3012544) pH of Venous blood

168

1.49

0.96

10.1

3.7

7.39

7.38

0.44

100

(46236952) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)/1.73 sq M

118

1.58

0.95

2.0

3.1

75.22

59.56

ml/min/173m2

—

(3002582) Erythrocytes [#/volume] in Urine

534

1.31

0.92

4.5

3.4

18.62

189.71

e6/l

0.80

418

(3021960) Folate [Moles/volume] in Serum or Plasma

461

1.31

0.88

2.2

1.7

24.54

21.52

nmol/l

0.61

379

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.90

0.88

2.6

1.6

—

(3023520) Reticulocytes [#/volume] in Blood

154

1.49

0.88

2.9

2.8

91.42

71.43

e9/l

1.13

112

(3030467) Casts [#/volume] in Urine by Automated count

452

1.31

0.88

4.0

3.3

0.40

0.39

e6/l

0.04

336

(3000475) Leukocytes [#/volume] in Synovial fluid

2.03

0.88

1.8

1.2

14900.83

2559.00

e6/l

—

(3027801) Oxygen [Partial pressure] in Arterial blood

198

1.43

0.86

14.0

6.7

12.15

11.48

kpa

0.56

190

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

198

1.43

0.86

14.0

6.7

5.24

5.08

kpa

0.48

187

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.81

0.85

2.4

1.5

—

(3022145) Colonoscopy Study observation

165

1.45

0.83

1.5

1.3

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

1.90

0.82

5.8

1.5

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.73

0.82

3.1

1.9

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

123

1.51

0.81

1.4

—

(3019977) pH of Arterial blood

201

1.40

0.80

14.0

6.7

7.41

0.14

130

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.70

0.80

5.0

1.6

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.70

0.80

4.7

1.8

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.70

0.80

4.9

1.6

—

(3042631) Mycobacterium sp identified in Specimen

2.11

0.75

2.6

3.7

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.59

0.74

1.5

1.3

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

1.95

0.71

1.8

1.9

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

260

1.33

0.71

3.7

3.0

2.41

0.94

e6/l

0.87

145

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.65

0.67

2.3

1.9

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

299

1.30

0.67

8.7

3.9

720.71

124.58

ng/l

0.43

233

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.53

0.65

8.1

2.7

1.02

1.25

0.95

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.53

0.65

8.1

2.7

0.58

0.61

0.12

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

121

1.45

0.65

1.5

1.4

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

1.69

0.62

3.4

1.8

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.60

0.0

1.5

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.60

0.0

1.3

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.60

0.0

1.7

—

(3029937) Albumin [Presence] in Urine by Test strip

473

1.23

0.60

5.9

4.0

0.00

estimate

-0.00

159

(4024509) Urine culture

1.60

0.60

2.3

1.7

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

629

1.21

0.58

5.1

4.0

0.00

0.01

estimate

0.50

145

(3020630) Protein [Mass/volume] in Serum or Plasma

133

1.39

0.57

9.7

3.2

65.23

66.80

g/l

0.33

124

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

148

1413

1.27

0.55

36.8

17.4

29.28

23.84

mg/l

0.82

130

1179

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.48

0.53

1.5

1.3

—

(40768443) Skin Pathology biopsy report

1.40

0.51

1.7

1.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

677

1.18

0.49

2.6

2.1

92.54

95.71

pmol/l

0.25

336

(4034850) Laboratory test

1.51

0.48

9.7

14.0

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

117

1098

1.19

0.48

5.3

4.2

14.99

14.89

pmol/l

0.19

111

990

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

827

1.18

0.47

3.3

3.0

—

(3004588) Protein electrophoresis panel - Serum or Plasma

112

1.37

0.46

9.0

2.6

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

326

1.21

0.43

3.1

2.7

2.48

2.46

mmol/l

0.41

291

(3009508) Creatinine [Moles/volume] in Urine

557

1.17

0.42

3.8

3.2

6.64

7.77

mmol/l

1.54

470

(3020682) Albumin/Creatinine [Ratio] in Urine

538

1.17

0.42

4.5

4.1

18.93

8.97

mg/mmol

0.43

345

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

1.37

0.41

6.1

2.0

99.25

457.46

ug/l

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

0.41

0.0

1.3

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.41

0.0

1.7

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.3

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.3

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.3

—

(3017569) Oxygen content in Arterial blood

0.00

0.41

0.0

5.4

—

16.59

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

1.48

0.40

1.0

1.4

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

1.48

0.40

1.0

1.4

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

1.48

0.40

1.0

1.4

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

299

0.81

0.39

3.5

3.1

0.68

0.79

ug/l

0.39

190

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.39

0.0

1.3

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.39

0.0

2.1

—

23.05

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

264

1.21

0.38

1.4

1.3

14.87

28.53

iu/ml

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

168

0.76

0.37

4.4

5.2

35.00

32.84

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.61

0.36

5.2

2.4

—

(3047181) Lactate [Moles/volume] in Blood

1.44

0.36

23.7

5.3

1.32

1.39

mmol/l

—

(1616796) Gas panel - Central venous blood

1.44

0.36

5.8

2.9

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.38

0.35

1.0

1.2

—

(3007566) Smooth muscle Ab [Titer] in Serum

1.34

0.34

1.2

—

78.57

—

(36660697) Celiac disease serology panel - Serum

132

0.74

0.33

1.2

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.31

0.33

1.5

1.2

—

(3019060) Gas panel - Arterial blood

110

1.30

0.33

12.4

3.4

—

(3012516) Albumin [Mass/volume] in Urine

522

1.13

0.30

4.0

3.4

93.58

56.95

mg/l

0.37

349

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

132

1365

0.88

0.29

5.8

5.3

6.11

6.03

mmol/l

0.30

123

1245

(3007164) IgA [Mass/volume] in Serum or Plasma

310

1.16

0.29

1.8

1.4

2.08

2.40

g/l

0.46

173

(3009343) pH of Capillary blood

122

1.25

0.28

4.3

2.8

7.43

7.42

0.28

100

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

178

1.20

0.27

4.8

3.5

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

104

1.27

0.27

3.9

2.9

0.56

2.06

mmol/l

—

(3019832) Treponema pallidum Ab [Presence] in Serum

123

1.24

0.26

2.2

1.7

—

(3037756) Immunofixation for Serum or Plasma

1.36

0.23

2.2

1.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

248

1.15

0.23

1.5

1.6

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.28

0.23

1.0

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

141

1373

1.12

0.22

5.1

1.43

1.45

mmol/l

0.10

132

1262

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

1.23

0.22

1.0

1.1

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

1.23

0.22

1.0

1.2

—

3.12

—

(3008898) HLA-B27 [Presence]

1.20

0.21

1.0

1.1

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

1.20

0.21

1.0

1.2

—

1.96

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.21

0.0

1.1

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.3

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.21

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.1

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.3

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

260

1.14

0.21

3.1

1.9

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.21

0.0

1.2

—

(3004451) EKG impression Narrative

0.00

0.21

0.0

1.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.4

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.20

0.0

1.3

—

8.21

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.20

0.0

1.9

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

338

1.12

0.20

2.0

1.8

1.06

1.45

mg/l

0.47

272

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.14

0.19

3.2

2.2

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

243

1.13

0.18

4.0

3.2

3.79

2.62

e6/l

—

129

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

234

1.13

0.18

1.4

1.3

1.75

7.32

u/ml

1.53

(40761536) Microorganisms panel - Urine sediment

129

1.18

0.17

3.3

3.7

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

965

0.92

0.17

3.7

3.3

48.41

49.76

u/l

0.07

908

(3007930) Methemoglobin/Hemoglobin.total in Blood

0.76

0.17

26.8

5.0

1.12

0.88

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

139

1.17

0.17

1.4

1.7

—

(4035726) Immunohistochemistry procedure

139

1.17

0.17

1.3

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

144

1411

1.10

0.16

6.0

2.51

2.64

mmol/l

1.00

135

1305

(1002224) Polysomnography panel

0.76

0.16

1.0

1.1

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

141

1382

1.09

0.15

5.2

4.42

4.54

mmol/l

0.66

132

1278

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

139

1362

1.09

0.15

7.8

6.7

40.68

40.03

mmol/mol

0.32

132

1274

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

344

1.10

0.15

1.2

1.3

0.64

1.04

u/ml

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

229

1.11

0.13

2.7

1.6

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

181

1.12

0.12

1.2

1.4

—

(3019225) pH of Specimen

126

1.12

0.09

8.2

4.3

7.36

7.31

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

0.82

0.08

22.7

4.8

1.75

1.54

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.08

0.07

1.1

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

128

1.10

0.07

2.6

2.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

140

1.08

0.04

2.5

2.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

459

0.97

0.02

3.6

3.5

0.00

estimate

-0.00

136

(40768797) Stomach Pathology biopsy report

197

0.96

0.01

1.5

1.3

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

136

1353

1.02

0.01

32.5

17.0

76.53

78.91

ml/min/173m2

0.51

129

1255

(3008152) Bicarbonate [Moles/volume] in Arterial blood

114

1.06

0.01

18.4

6.2

25.64

24.73

mmol/l

0.38

109

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

184

1.04

0.00

14.7

9.0

—

(40761511) CBC panel - Blood by Automated count

144

1446

0.98

0.00

27.7

15.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

126

1.03

0.00

1.7

1.5

—

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

152

1524

0.98

0.00

52.0

26.2

38.90

40.24

2.00

152

1510

(3035941) MCH [Entitic mass]

152

1524

0.98

0.00

51.1

25.8

30.40

30.32

0.20

152

1511

(3000963) Hemoglobin [Mass/volume] in Blood

152

1524

0.98

0.00

51.8

26.0

130.32

134.90

g/l

3.24

152

1509

(3003694) ABO and Rh group [Type] in Blood

391

1.00

0.00

1.4

1.5

—

(3024731) MCV [Entitic mean volume] in Red Blood Cells

152

1523

0.99

0.00

51.2

25.8

91.90

91.08

1.16

152

1510

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

405

0.98

0.00

4.6

4.7

19.27

22.56

0.54

203

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

515

1.01

0.00

5.8

5.4

1.95

2.13

ug/l

0.18

462

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

131

1308

1.01

0.00

4.4

1.27

1.28

mmol/l

0.05

124

1194

(3000492) Spirometry study

145

1.04

0.00

1.3

1.4

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.6

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.4

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

0.96

0.00

1.0

1.3

—

(3022313) Gas panel - Capillary blood

0.96

0.00

5.4

2.8

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

0.35

—

(3011544) Albumin [Mass/volume] in Pleural fluid

0.00

0.0

1.0

—

18.60

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

0.96

0.00

3.4

1.5

14.24

22.15

iu/l

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.2

—

(42529528) Centromere protein B Ab [Units/volume] in Serum by Line blot

0.00

-0.00

0.0

1.3

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

-0.00

0.0

1.0

—

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

0.00

-0.00

0.0

1.7

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.95

-0.00

3.2

2.3

—

(3014891) Appearance of Pleural fluid

0.00

-0.00

0.0

1.2

—

(3020650) Glucose [Presence] in Urine

0.00

-0.00

0.0

1.1

—

0.00

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.87

-0.00

1.6

2.7

6.28

10.26

g/l

—

(40758292) HTLV I+II Ab panel - Serum

0.00

-0.00

0.0

1.5

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(44813793) Dust mix specific IgE antibody measurement

0.00

-0.00

0.0

1.0

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3015076) Soybean IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3022689) Creatine [Moles/volume] in Urine

0.00

-0.00

0.0

1.4

—

11.06

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3014271) Vancomycin [Susceptibility]

0.00

-0.00

0.0

1.8

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.3

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3015024) Glucose [Moles/volume] in Serum or Plasma --1 hour post dose glucose

0.00

-0.00

0.0

1.5

—

8.14

—

(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.9

—

4.11

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

-0.00

0.0

1.0

—

6.21

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3020911) Cortisol [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.0

—

49.86

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

1.02

-0.00

1.5

3.0

0.08

0.22

g/l

—

Mortality – FinRegistry

↥

Association

Association between endpoint I9_RHEUFEVHRT and mortality.

Females

Parameter	HR [95% CI]	p-value
I9_RHEUFEVHRT	1.944 [1.55, 2.44]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.117

During the follow-up period (1.1.1998 — 31.12.2019), 159 out of 399 females with I9_RHEUFEVHRT died.

Males

Parameter	HR [95% CI]	p-value
I9_RHEUFEVHRT	1.889 [1.43, 2.5]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.004

During the follow-up period (1.1.1998 — 31.12.2019), 139 out of 376 males with I9_RHEUFEVHRT died.

Mortality risk

Mortality risk for people of age

years, who have I9_RHEUFEVHRT.

N-year risk	Females	Males
1	0.185%	0.435%
5	1.056%	2.189%
10	2.706%	5.49%
15	5.191%	10.508%
20	8.884%	17.473%

Relationships between endpoints

↥

Index endpoint: I9_RHEUFEVHRT – Rheumatic fever with heart involvement

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Rheumatic fever with heart involvement

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints