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Rheumatic valve diseases

DOID EFO Endpoint Browser PheWeb

I9_RHEUVALV

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I05, I06, I07, I08
  • Hospital discharge: ICD-9 — 39[4-6]
  • Hospital discharge: ICD-8 — 3940|3950|3960|3970
  • Cause of death: ICD-10 — I05, I06, I07, I08
  • Cause of death: ICD-9 — 39[4-6]
  • Cause of death: ICD-8 — 3940|3950|3960|3970

2 out of 7 registries used, show all original rules.

1031

4. Check minimum number of events

None

1031

5. Include endpoints

None

1031

6. Filter based on genotype QC (FinnGen only)

890

Control definitions (FinnGen only)

Control exclude
I9_RHEUFEV

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 16608 8594 7551
Only index persons 6507 3468 3039
Unadjusted period prevalence (%)
Whole population 0.24 0.25 0.21
Only index persons 0.12 0.13 0.12
Median age at first event (years)
Whole population 64.36 67.55 60.72
Only index persons 57.15 61.05 52.70

-FinnGen-

Key figures

All Female Male
Number of individuals 890 381 509
Unadjusted period prevalence (%) 0.19 0.14 0.23
Median age at first event (years) 56.70 52.43 59.89

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
934
Matched controls
9340
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
28.0
318.5
229
107
I06.9
ICD-10 Finland
Rheumatic aortic valve disease, unspecified
+∞
227.7
209
*
B01AA03
ATC
warfarin; systemic
5.6
151.4
556
1942
201
Kela drug reimbursment
Chronic cardiac insufficiency
6.7
140.1
278
559
I35.0
ICD-10 Finland
Aortic (valve) stenosis
6.5
126.3
249
494
I34.2
ICD-10 Finland
Nonrheumatic mitral (valve) stenosis
54.8
124.3
71
14
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
9.9
120.1
149
175
C01AA05
ATC
digoxin; systemic
4.9
111.5
339
975
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
7.4
109.3
178
288
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
12.7
106.1
108
95
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
19.7
104.8
83
46
5253
FHL
Cardiac lung machine
15.0
92.3
84
61
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
7.5
90.5
142
219
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
4.0
88.5
362
1269
K83
ICPC
Heart valve disease NOS
20.7
83.2
64
33
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
30.7
83.0
55
19
I05.0
ICD-10 Finland
Mitral stenosis
+∞
80.4
76
*
XF640, ,
NOMESCO Finland
8.9
79.6
104
129
5273
FHL
Repair with flap prosthesis or graft
149.6
78.3
82
6
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
5.9
76.1
151
294
I06.0
ICD-10 Finland
Rheumatic aortic stenosis
+∞
76.1
72
*
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
7.7
74.4
111
161
I48
ICD-10 Finland
Atrial fibrillation and flutter
3.4
73.4
474
2179
I08.0
ICD-10 Finland
Disorders of both mitral and aortic valves
+∞
72.9
69
*
3950A
ICD-9 Finland
Diseases of aortic valve, Rheumatic aortic stenosis
+∞
63.2
60
*
I34.1
ICD-10 Finland
Mitral (valve) prolapse
8.3
61.2
84
110
I50.9
ICD-10 Finland
Heart failure, unspecified
3.1
59.9
373
1636
I50.0
ICD-10 Finland
Congestive heart failure
3.6
58.2
239
812
I05.2
ICD-10 Finland
Mitral stenosis with insufficiency
+∞
57.9
55
*
62
HP
Catheterization and pressure measurement of the right side of the heart
24.5
55.9
40
17
39501
ICD-8 Finland
Diseases of aortic valve, Cum insufficientia (febris rheumatica inactiva)
+∞
55.8
53
*
C03CA01
ATC
furosemide; systemic
2.9
54.1
578
3346
I05.1
ICD-10 Finland
Rheumatic mitral insufficiency
+∞
53.7
51
*
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
5.6
50.7
102
199
I06.1
ICD-10 Finland
Rheumatic aortic insufficiency
+∞
50.5
48
*
C07AA07
ATC
sotalol; systemic
4.8
50.1
122
281
42700
ICD-8 Finland
Symptomatic heart disease, Congestive heart failure
13.8
48.8
46
35
C03DA01
ATC
spironolactone; oral
3.2
48.4
239
901
3952A
ICD-9 Finland
Diseases of aortic valve, Rheumatic aortic stenosis with insufficiency
+∞
48.3
46
*
3951A
ICD-9 Finland
Diseases of aortic valve, Rheumatic aortic insufficiency
+∞
47.3
45
*
I34.9
ICD-10 Finland
Nonrheumatic mitral valve disorder, unspecified
14.2
44.4
41
30
I06.2
ICD-10 Finland
Rheumatic aortic stenosis with insufficiency
+∞
42.0
40
*
42792
ICD-8 Finland
Symptomatic heart disease, Fibrillatio auricularis
9.5
41.6
50
55
39500
ICD-8 Finland
Diseases of aortic valve, Cum stenosi (febris rheumatica inactiva)
+∞
40.9
39
*
81
HP
Angiography of the heart and coronary arteries
3.5
40.9
162
529
I05.9
ICD-10 Finland
Mitral valve disease, unspecified
+∞
39.9
38
*
4241B
ICD-9 Finland
Other diseases of endocardium, Aortic valve disorders[STENOSIS VALVULAE AORTAE (NON RHEUMATICA)]
60.4
39.6
46
8
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
7.6
39.4
57
79
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
7.2
37.7
57
83
I50.1
ICD-10 Finland
Left ventricular failure
3.5
35.7
137
437
61
HP
Catheterization and pressure measurement of the left side of the heart
5.7
34.1
65
120
39401
ICD-8 Finland
Diseases of mitral valve, Cum insufficientia (febris rheumatica inactiva)
+∞
33.5
32
*
207
Kela drug reimbursment
Chronic arrhythmias
2.5
33.2
265
1261
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.4
33.1
308
1572
FKD00
NOMESCO Finland
Replacement of mitral valve using mechanical prosthesis
93.6
33.0
36
*
39502
ICD-8 Finland
Diseases of aortic valve, Cum stenosi et insufficientia (febris rheumatica inactiva)
+∞
32.5
31
*
4241A
ICD-9 Finland
Other diseases of endocardium, Aortic valve disorders[INSUFFICIENTIA VALVULAE AORTAE (NON RHEUMATICA)]
90.9
31.9
35
*
I34.0
ICD-10 Finland
Mitral (valve) insufficiency
6.7
30.1
49
77
21
HP
Aortic Valve Replacement (AVR)
58.7
29.3
34
6
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
3.3
28.5
116
382
3941A
ICD-9 Finland
Diseases of mitral valve, Rheumatic mitral insufficiency
+∞
28.3
27
*
TFP20
NOMESCO Finland
Cardiodefibrillation
3.2
28.3
127
444
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
7.0
27.4
42
62
C01BD01
ATC
amiodarone; systemic
5.0
27.0
60
127
FKD10
NOMESCO Finland
Replacement of mitral valve using biological prosthesis
45.7
25.7
31
7
I35.9
ICD-10 Finland
Aortic valve disorder, unspecified
8.9
25.5
32
37
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.2
25.5
271
1439
AB2
HP
AVR bio, stent
9.7
25.4
30
32
AN1
HP
Coronary angiography
2.6
25.2
178
789
I07.1
ICD-10 Finland
Tricuspid insufficiency
+∞
25.1
24
*
4241C
ICD-9 Finland
Other diseases of endocardium, Aortic valve disorders[INSUFFICIENTIA/STENOSIS VALVULAE AORTAE (NON RHEUM)]
133.6
24.7
26
*
3940A
ICD-9 Finland
Diseases of mitral valve, Mitral stenosis
+∞
24.1
23
*
C07AB07
ATC
bisoprolol; oral
2.0
24.0
569
4046
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
3.0
24.0
118
433
C07AB02
ATC
metoprolol; systemic
2.1
24.0
306
1741
XF400
NOMESCO Finland
ECG with 12 standard connections
2.3
23.9
223
1118
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
4.9
23.9
54
116
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.4
23.2
87
271
B01AB05
ATC
enoxaparin; parenteral
2.1
23.2
327
1926
39400
ICD-8 Finland
Diseases of mitral valve, Cum stenosi (febris rheumatica inactiva)
+∞
23.0
22
*
5284
FHL
Mitral defect correction with flap prosthesis or graft
235.5
22.7
23
*
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
2.8
22.7
127
500
3960A
ICD-9 Finland
Diseases of mitral and aortic valves, Mitral valve stenosis and aortic valve stenosis
+∞
20.9
20
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.2
19.8
214
1130
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
3.1
19.5
86
296
K84
ICPC
Heart disease other
4.2
19.5
53
132
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
16.0
19.4
31
20
K78
ICPC
Atrial fibrillation/flutter
2.5
19.0
132
576
39409
ICD-8 Finland
Diseases of mitral valve, Unspecified
+∞
18.8
18
*
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
3.1
18.8
81
275
WX872
NOMESCO Finland
Intensive care
3.3
18.8
74
238
4240A
ICD-9 Finland
Other diseases of endocardium, Mitral valve disorders[INSUFFICIENTIA VALVULAE MITRALIS (NON RHEUMATICA)]
25.6
18.3
25
10
AC2
HP
MVR bio
183.3
17.6
18
*
4130B
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),AHTAUTUNUT]
4.0
17.5
51
134
XFE00
NOMESCO Finland
Epicardial ultrasonography
4.2
17.0
46
114
I34.8
ICD-10 Finland
Other nonrheumatic mitral valve disorders
64.6
16.8
19
*
3942A
ICD-9 Finland
Diseases of mitral valve, Mitral stenosis with insufficiency
+∞
16.7
16
*
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
2.9
16.3
82
304
AP2
HP
Catheterization of the right side of the heart
25.0
16.1
22
9
M04AA01
ATC
allopurinol; systemic
2.0
16.0
195
1069
39402
ICD-8 Finland
Diseases of mitral valve, Cum stenosi et insufficientia (febris rheumatica inactiva)
+∞
15.7
15
*
XF404
NOMESCO Finland
Ambulatory ECG
2.5
15.5
107
464
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
4.2
15.5
41
100
M01AE01
ATC
ibuprofen; systemic, rectal
0.6
15.2
475
6007
C02EA02, ,
ATC
2.6
14.9
88
354
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.2
14.9
62
206
FCA60
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of composite graft with mechanical valve prosthesis
32.3
14.8
19
6
39509
ICD-8 Finland
Diseases of aortic valve, Unspecified
+∞
14.6
14
*
I08.1
ICD-10 Finland
Disorders of both mitral and tricuspid valves
+∞
14.6
14
*
39403
ICD-8 Finland
Diseases of mitral valve, Operata (febris rheumatica inactiva)
+∞
14.6
14
*
L04AA06
ATC
mycophenolic acid; systemic
6.5
14.6
24
38
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.2
14.5
127
611
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
4.0
14.4
42
110
42798
ICD-8 Finland
Symptomatic heart disease, Alia arrhytmia definita
6.3
14.3
24
39
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.3
14.2
115
536
FGC10
NOMESCO Finland
Annuloplasty of tricuspid valve using prosthetic ring
30.5
13.9
18
6
I33.9
ICD-10 Finland
Acute endocarditis, unspecified
30.5
13.9
18
6
4289X
ICD-9 Finland
Heart failure, unspecified
4.9
13.6
30
63
22
HP
Mitral valve Replacement (MVR)
76.3
13.6
15
*
42410
ICD-8 Finland
Chronic disease of endocardium, Aortae, non operata
+∞
13.6
13
*
I08.3
ICD-10 Finland
Combined disorders of mitral, aortic and tricuspid valves
+∞
13.6
13
*
I07.2
ICD-10 Finland
Tricuspid stenosis with insufficiency
+∞
13.6
13
*
C09AA02
ATC
enalapril; systemic
1.8
13.5
245
1526
A12BA01
ATC
potassium chloride; oral
2.3
13.3
104
477
I50
ICD-10 Finland
Heart failure
2.8
13.0
68
257
TFC20
NOMESCO Finland
Catheterisation of both sides of heart
19.4
12.9
19
10
J01DA01
ATC
[U] cefalexin
1.7
12.9
569
4498
R04.0
ICD-10 Finland
Epistaxis
2.3
12.9
103
477
C08DA01
ATC
verapamil; systemic
2.6
12.8
75
301
Z95.3
ICD-10 Finland
Presence of xenogenic heart valve
11.2
12.6
23
21
39503
ICD-8 Finland
Diseases of aortic valve, Operata (febris rheumatica inactiva)
+∞
12.5
12
*
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
16.1
12.2
19
12
R50.9
ICD-10 Finland
Fever, unspecified
2.0
12.0
153
848
C01BA03
ATC
disopyramide; systemic
5.5
11.9
23
43
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.8
11.8
36
98
25
HP
Valve and coronary artery bypass surgery
19.2
11.6
17
9
J01FF01
ATC
clindamycin; systemic
1.8
11.5
232
1482
24
HP
Multi-valve repair or other valve surgery
+∞
11.5
11
*
74673
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae aortae
+∞
11.5
11
*
I48.2
ICD-10 Finland
Chronic atrial fibrillation
2.5
11.4
73
305
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
11.4
445
3369
AD1
HP
TVP
35.5
11.3
14
*
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.6
11.1
316
2211
R06.0
ICD-10 Finland
Dyspnoea
1.7
11.0
277
1878
ZXD05
NOMESCO Finland
Urgent procedure
1.7
11.0
287
1964
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
4.8
10.8
24
51
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
2.8
10.6
53
196
I71.9
ICD-10 Finland
Aortic aneurysm of unspecified site, without mention of rupture
4.6
10.5
25
56
TK800
NOMESCO Finland
Hemodialysis
4.2
10.5
28
69
C02EA01, ,
ATC
4.2
10.5
28
69
4130X
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),MÄÄRITTELEMÄT]
2.8
10.4
51
186
42100
ICD-8 Finland
Acute and subacute endocarditis, Acute and subacute bacterial endocarditis
+∞
10.4
10
*
39604
ICD-8 Finland
Diseases of mitral and aortic valves, Non operata
+∞
10.4
10
*
127
Kela drug reimbursment
Transplant complication
8.3
10.4
22
27
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
10.7
10.3
19
18
J01CA04
ATC
amoxicillin; systemic
1.6
10.2
662
5590
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
10.1
259
1758
PD5AD
NOMESCO Finland
CT of aorta
3.5
9.9
34
100
ZSF00
NOMESCO Finland
Procedure related to previous procedure classified in chapter F
16.9
9.9
15
9
Z95.4
ICD-10 Finland
Presence of other heart-valve replacement
16.9
9.9
15
9
C01BA01
ATC
quinidine; oral
5.2
9.9
20
39
FPE00
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with ventricular electrode
2.8
9.8
50
187
4240X
ICD-9 Finland
Other diseases of endocardium, Mitral valve disorders[ALIUD VITIUM VALVULAE MITRALIS (NON RHEUMATICUM)]
55.6
9.7
11
*
7865A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Chest pain
3.3
9.5
35
108
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.4
9.5
66
287
42400
ICD-8 Finland
Chronic disease of endocardium, Mitralis, non-operata
101.0
9.4
10
*
42411
ICD-8 Finland
Chronic disease of endocardium, Aortae, operata
+∞
9.4
9
*
74679
ICD-8 Finland
Congenital anomalies of heart, Aliae malformationes valvulae aortae sive ventriculi sinistri
+∞
9.4
9
*
L04AA01
ATC
[U] ciclosporin
8.1
9.4
20
25
I42.0
ICD-10 Finland
Dilated cardiomyopathy
3.1
9.3
38
125
ZXE20
NOMESCO Finland
More than three and less than five hours
1.9
9.2
134
773
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
8.9
266
1867
K99
ICPC
Cardiovascular disease other
3.0
8.7
38
130
I44.2
ICD-10 Finland
Atrioventricular block, complete
2.5
8.7
53
217
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.0
8.7
97
511
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
2.9
8.6
39
137
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.5
8.5
314
2306
J01MA12
ATC
levofloxacin; systemic
1.7
8.5
185
1198
39609
ICD-8 Finland
Diseases of mitral and aortic valves, Unspecified
+∞
8.3
8
*
39601
ICD-8 Finland
Diseases of mitral and aortic valves, Mitralium operata
+∞
8.3
8
*
PD5BD
NOMESCO Finland
Extensive CT of aorta
3.7
8.3
26
72
250, ,
Kela drug reimbursment
3.6
8.2
26
73
Z2221
NOMESCO Finland
Medical doctor
1.6
8.1
231
1597
J01FA10
ATC
azithromycin; systemic
1.5
8.1
385
2979
I35
ICD-10 Finland
Nonrheumatic aortic valve disorders
9.0
8.1
16
18
Z94.1
ICD-10 Finland
Heart transplant status
22.2
8.0
11
5
R58
ICD-10 Finland
Haemorrhage, not elsewhere classified
3.6
8.0
26
74
GD1LA
NOMESCO Finland
GD
3.9
8.0
23
60
FCA50
NOMESCO Finland
Resection and reconstruction of ascending aorta using tube graft
15.2
7.7
12
8
C01DA14
ATC
isosorbide mononitrate; oral
1.6
7.6
249
1772
I38
ICD-10 Finland
Endocarditis, valve unspecified
18.5
7.6
11
6
AP3
HP
Catheterization of the right and left side of the heart
12.0
7.6
13
11
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
1.9
7.6
96
529
L04AX01
ATC
azathioprine; systemic
2.7
7.5
38
142
4660A
ICD-9 Finland
Acute bronchitis and bronchiolitis, Acute bronchitis
4.5
7.4
18
41
4210A
ICD-9 Finland
Acute and subacute endocarditis, Acute and subacute bacterial endocarditis
80.7
7.4
8
*
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
6.0
7.4
19
32
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.1
7.4
74
375
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
3.8
7.4
22
59
TFN04, ,
NOMESCO Finland
6.9
7.3
17
25
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
3.2
7.3
28
89
AC4
HP
MVP
11.0
7.3
13
12
I07.9
ICD-10 Finland
Tricuspid valve disease, unspecified
+∞
7.3
7
*
74659
ICD-8 Finland
Congenital anomalies of heart, Maleformatio valvulae mitralis
+∞
7.3
7
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
7.3
205
1409
D64.9
ICD-10 Finland
Anaemia, unspecified
1.7
7.3
137
850
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
1.5
7.3
261
1894
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
7.3
306
2296
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
7.2
179
1193
4412A
ICD-9 Finland
Aortic aneurysm, Thoracic aneurysm without mention of rupture
30.3
7.2
9
*
5311
FHL
Bypass surgery in one vein
20.2
7.1
10
5
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
7.1
184
1239
I34.01
ICD-10 Finland
Mitral (valve) regurgitation NOS or of specified cause, except rheumatic
8.0
7.1
15
19
L04AD01
ATC
ciclosporin; systemic
5.7
7.1
19
34
H02AB06
ATC
prednisolone; systemic
1.5
7.1
407
3242
J01FA06
ATC
roxithromycin; oral
1.5
7.1
337
2589
I40.9
ICD-10 Finland
Acute myocarditis, unspecified
8.9
7.1
14
16
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.5
7.0
245
1766
N05BA01
ATC
diazepam; systemic, rectal
1.7
7.0
123
750
I49.5
ICD-10 Finland
Sick sinus syndrome
2.1
6.9
61
294
N05CF01
ATC
zopiclone; oral
1.5
6.9
325
2488
H02AB07
ATC
prednisone; oral
1.7
6.9
136
855
M01AH05
ATC
etoricoxib; oral
0.7
6.9
253
3341
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
6.8
324
2483
H53.1
ICD-10 Finland
Subjective visual disturbances
2.2
6.8
58
276
I97.0
ICD-10 Finland
Postcardiotomy syndrome
11.0
6.8
12
11
AB1
HP
AVR mechanical
11.0
6.8
12
11
I48.1
ICD-10 Finland
Persistent atrial fibrillation
2.3
6.8
52
237
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
6.8
277
2061
I47.2
ICD-10 Finland
Ventricular tachycardia
3.2
6.8
26
83
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
3.6
6.7
22
63
A41.9
ICD-10 Finland
Sepsis, unspecified
2.3
6.7
48
212
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.8
6.7
99
572
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
6.7
322
2473
C09AA01
ATC
captopril; oral
2.6
6.7
37
145
I34
ICD-10 Finland
Nonrheumatic mitral valve disorders
22.7
6.7
9
*
73
HP
Initial pacemaker installation
3.8
6.7
20
54
Z94.0
ICD-10 Finland
Kidney transplant status
7.9
6.6
14
18
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.6
6.6
21
59
42799
ICD-8 Finland
Symptomatic heart disease, Other and unspecified disorders or heart rhythm
12.3
6.6
11
9
41399
ICD-8 Finland
Angina pectoris, Without mention of hypertensive disease
3.1
6.5
27
90
I49.3
ICD-10 Finland
Ventricular premature depolarization
2.1
6.5
58
281
I47.1
ICD-10 Finland
Supraventricular tachycardia
2.5
6.5
41
171
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
2.8
6.5
32
118
D59.4
ICD-10 Finland
Other nonautoimmune haemolytic anaemias
70.3
6.4
7
*
XFP02, ,
NOMESCO Finland
14.4
6.4
10
7
Z49.1
ICD-10 Finland
Extracorporeal dialysis
4.1
6.4
17
42
Z3231
NOMESCO Finland
Registered nurse
1.5
6.3
236
1720
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
6.3
152
1006
42401
ICD-8 Finland
Chronic disease of endocardium, Mitralis, operata
+∞
6.3
6
*
39602
ICD-8 Finland
Diseases of mitral and aortic valves, Aortae operata
+∞
6.3
6
*
AC1
HP
MVR mechanical
26.9
6.2
8
*
7806A
ICD-9 Finland
General symptoms, Pyrexia of unknown origin
6.3
6.2
15
24
X57
ICD-10 Finland
Unspecified privation
3.0
6.1
26
88
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
1.8
6.1
88
505
N05CD07
ATC
temazepam; oral
1.6
6.1
150
997
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.0
6.0
66
346
R02
ICPC
Shortness of breath/dyspnoea
1.7
6.0
119
748

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
389
2675
1.78
15.79
5.8
3.4
2643.40
2062.62
ng/l
1.23
356
2309
135
714
2.04
12.04
12.5
6.4
13.60
11.60
mmol/l
1.87
122
681
88
402
2.31
11.34
2.6
1.8
1.22
1.56
g/l
2.17
62
358
124
694
1.91
9.33
3.7
3.3
339.54
271.12
ng/l
0.65
114
636
59
252
2.43
8.85
2.7
3.4
0.90
0.86
nmol/l
0.18
45
208
124
715
1.85
8.49
2.2
2.6
14.33
6.58
ug/l
1.25
107
606
189
1269
1.61
7.43
4.7
2.5
2.26
2.24
g/l
0.21
171
1173
178
1184
1.62
7.26
4.9
2.5
20.05
21.45
%
0.84
164
1107
200
1369
1.59
7.24
4.6
2.5
11.05
11.89
umol/l
1.33
179
1272
457
3716
1.45
7.15
82.0
19.0
2.04
1.37
inr
46.77
399
3148
58
281
2.13
6.53
3.5
5.1
25.33
25.12
mmol/l
0.25
50
261
594
6671
0.70
6.18
47.9
28.8
128.40
131.59
g/l
4.61
583
6556
594
6671
0.70
6.18
47.5
28.6
6.99
7.03
e9/l
0.13
581
6479
594
6668
0.70
6.13
47.5
28.6
224.10
239.72
e9/l
6.50
581
6500
594
6668
0.70
6.13
47.5
28.6
4.32
4.37
e12/l
1.07
582
6476
594
6668
0.70
6.13
49.1
29.1
38.80
39.27
%
1.32
583
6547
594
6668
0.70
6.13
47.3
28.5
30.06
30.39
pg
3.78
583
6552
594
6666
0.70
6.10
47.3
28.5
91.19
91.67
fl
1.46
583
6552
144
970
1.57
5.50
10.5
6.3
7.41
7.42
ph
0.24
76
575
141
962
1.55
5.09
10.7
6.3
0.80
1.03
mmol/l
0.26
111
773
152
1055
1.53
5.07
9.5
5.2
1.07
1.04
mmol/l
0.84
132
955
108
693
1.63
5.04
15.0
7.3
—
—
—
0
0
593
6581
0.73
4.94
40.1
25.4
95.86
85.11
umol/l
4.19
578
6455
147
1026
1.51
4.77
3.4
2.5
1.81
1.80
%
0.02
131
915
579
6429
0.74
4.66
16.5
12.2
24.23
24.94
u/l
0.56
560
6190
140
979
1.51
4.50
10.6
6.2
5.22
5.08
kpa
0.91
130
929
140
980
1.50
4.48
10.5
6.2
12.16
11.49
kpa
0.53
130
933
125
854
1.54
4.48
2.4
1.7
—
—
—
0
0
81
499
1.68
4.44
14.9
7.7
24.09
24.35
mmol/l
0.28
75
479
38
183
2.12
4.42
1.1
1.2
—
—
—
0
0
52
282
1.89
4.37
5.5
3.3
69.00
73.08
mg/l
0.07
43
238
52
284
1.88
4.28
5.5
3.3
41.18
62.45
mg/l
0.80
43
241
283
2266
1.36
4.26
8.5
5.5
—
—
—
0
0
584
6445
0.75
4.24
39.5
23.6
4.03
4.01
mmol/l
1.16
569
6277
584
6440
0.75
4.18
39.1
23.4
139.18
139.52
mmol/l
2.34
570
6281
115
785
1.53
4.14
3.0
2.7
68.73
67.84
e9/l
0.09
85
595
63
370
1.75
4.11
4.0
4.5
—
—
—
0
0
83
529
1.62
4.01
3.9
4.2
7.42
7.41
ph
0.04
69
453
125
875
1.49
4.00
11.2
6.5
95.51
94.97
%
0.58
119
842
47
255
1.89
3.96
5.3
3.0
13.84
2.51
ratio
0.59
26
149
438
5004
0.77
3.96
42.7
25.1
328.92
331.05
g/l
4.56
432
4955
145
1933
0.70
3.68
3.2
3.4
—
—
—
0
0
83
541
1.59
3.67
3.9
4.2
5.20
5.16
kpa
0.14
75
521
539
5967
0.77
3.67
6.2
5.9
2.41
2.54
mmol/l
2.72
502
5388
26
117
2.26
3.60
1.7
1.4
—
—
—
0
0
520
5771
0.78
3.53
7.1
7.0
40.82
40.46
mmol/mol
0.34
483
5288
526
5827
0.78
3.51
5.4
5.1
4.21
4.42
mmol/l
4.49
491
5293
80
523
1.58
3.50
15.2
7.8
1.33
1.35
%
0.12
80
518
521
5777
0.78
3.49
5.4
5.0
1.36
1.43
mmol/l
3.68
482
5207
578
6326
0.77
3.48
28.8
17.5
—
—
—
0
0
101
705
1.49
3.29
3.3
2.5
65.40
66.04
g/l
0.35
94
636
145
1085
1.40
3.26
2.9
2.0
—
—
—
0
0
285
2361
1.30
3.25
6.1
4.4
—
—
—
0
0
261
2140
1.30
3.21
3.2
2.3
3.45
3.08
mg/l
1.50
232
1837
536
5884
0.79
3.08
5.6
5.4
6.10
6.08
mmol/l
0.10
485
5247
161
1238
1.36
3.07
5.2
3.0
0.83
0.82
mmol/l
0.59
152
1163
209
2564
0.76
3.00
4.7
5.8
2.82
3.70
ug/l
0.63
187
2260
452
5051
0.80
3.00
40.0
23.6
14.55
13.92
%
9.40
446
4979
72
480
1.54
2.93
5.8
3.3
23.63
23.98
mmol/l
0.39
67
473
361
3114
1.26
2.91
9.8
5.8
9.36
9.08
%
0.91
335
2902
360
3107
1.26
2.89
9.6
5.7
2.61
2.79
%
1.04
334
2895
360
3108
1.26
2.88
9.8
5.8
0.64
0.63
%
0.07
334
2887
6
9
6.70
2.87
5.0
2.1
—
—
—
0
0
87
607
1.48
2.86
6.1
3.7
140.08
94.87
ng/l
1.40
73
520
393
3436
1.25
2.79
9.6
5.9
0.19
0.20
e9/l
0.50
338
2959
36
203
1.80
2.77
4.1
3.7
2.92
1.49
index
0.68
25
111
18
78
2.33
2.76
1.1
1.2
—
—
—
0
0
581
6282
0.80
2.70
32.3
19.2
25.08
27.64
mg/l
1.31
532
5371
380
3322
1.24
2.67
9.4
5.7
0.66
0.62
e9/l
2.19
329
2810
504
5530
0.81
2.67
4.7
4.3
1.29
1.26
mmol/l
0.43
464
4927
12
43
2.81
2.65
2.1
1.8
35.96
39.04
%
0.20
12
43
8
20
4.03
2.57
1.8
1.6
—
—
—
0
0
35
201
1.77
2.55
3.2
2.5
60.86
60.11
%
0.06
30
194
6
11
5.48
2.54
1.0
1.0
—
—
—
0
0
380
3337
1.23
2.53
9.5
5.7
0.04
0.04
e9/l
0.12
331
2830
11
38
2.92
2.42
4.9
3.4
1.18
0.79
index
0.73
11
38
110
828
1.37
2.41
2.6
2.9
11.09
9.49
umol/l
0.31
92
723
17
77
2.23
2.38
3.0
2.1
—
—
—
0
0
10
33
3.05
2.36
2.4
1.4
—
—
—
0
0
428
4739
0.82
2.33
4.6
4.1
15.31
15.05
pmol/l
1.36
386
4227
22
112
1.99
2.32
1.4
1.3
12648.00
94583.15
e6/l
0.84
14
65
80
574
1.43
2.32
3.1
2.3
—
—
—
0
0
352
3091
1.22
2.29
9.6
5.8
61.33
58.99
%
3.18
331
2934
527
5708
0.82
2.24
5.7
5.2
2.12
2.01
mu/l
1.08
483
5142
382
3389
1.22
2.23
9.5
5.8
1.72
1.85
e9/l
0.56
332
2955
344
3022
1.22
2.21
6.5
4.4
53.34
77.30
ng/l
0.48
271
2354
97
727
1.37
2.20
6.2
2.9
4.31
4.35
kpa
0.08
91
700
113
868
1.34
2.19
7.2
3.5
7.36
7.38
ph
0.97
68
538
21
108
1.97
2.16
1.8
1.4
—
—
—
0
0
357
3154
1.21
2.16
9.7
5.9
23.25
25.61
%
3.66
338
2977
35
557
0.61
2.16
1.9
1.4
—
—
—
0
0
27
152
1.80
2.14
1.5
1.4
28.89
30.20
g/l
0.33
21
135
23
123
1.89
2.13
2.2
1.5
—
—
—
0
0
109
839
1.34
2.09
7.2
3.4
1.24
1.89
mmol/l
1.04
95
684
5
10
5.02
2.07
1.0
1.2
—
—
—
0
0
5
10
5.02
2.07
2.8
9.3
5.06
4.89
kpa
—
5
10
5
147
0.34
2.02
1.6
1.6
572.60
300.22
mu/l
—
5
137
100
771
1.33
1.91
4.6
3.2
5.89
5.30
e9/l
0.20
87
652
17
85
2.02
1.91
4.2
2.4
1.13
1.32
g/24h
—
10
48
86
649
1.36
1.89
2.4
2.4
38.61
34.09
u/l
0.44
70
543
214
2496
0.81
1.88
2.1
2.3
—
—
—
0
0
23
129
1.80
1.87
1.5
1.3
1180.60
1345.48
e6/l
0.11
15
87
110
863
1.31
1.87
7.1
3.4
5.95
5.80
kpa
0.81
104
832
0
54
0.00
1.85
0.0
1.4
—
—
—
0
0
21
115
1.85
1.84
1.4
1.4
—
—
—
0
0
30
183
1.66
1.83
1.9
1.6
—
—
—
0
0
5
12
4.18
1.82
3.0
1.6
—
—
—
0
0
47
320
1.49
1.82
2.6
2.3
0.00
0.01
estimate
0.49
15
90
78
584
1.37
1.81
1.9
1.5
—
—
—
0
0
99
769
1.32
1.81
1.4
1.3
638.40
440.69
titre
0.46
25
173
145
1186
1.26
1.79
1.9
1.4
2.91
2.67
g/l
0.47
81
687
121
1490
0.78
1.73
3.0
3.4
0.80
0.83
ug/l
0.13
83
1020
39
259
1.53
1.71
3.4
3.1
279.78
268.00
mg/l
0.04
18
103
207
1775
1.21
1.66
4.0
2.9
393.93
360.35
umol/l
3.33
174
1514
7
25
2.81
1.65
1.3
1.2
—
—
—
0
0
181
1532
1.23
1.65
5.3
4.3
243.99
279.10
ng/l
0.14
162
1324
64
853
0.73
1.64
1.3
1.4
—
—
—
0
0
201
1723
1.21
1.61
3.8
2.4
—
—
—
0
0
264
2322
1.19
1.61
3.8
2.5
—
—
—
0
0
14
70
2.02
1.59
1.8
2.0
—
—
—
0
0
7
26
2.70
1.58
1.0
1.1
—
—
—
0
0
157
1316
1.23
1.57
4.3
3.2
1.14
1.19
e6/l
0.04
90
723
137
1642
0.81
1.55
2.6
3.1
2.46
2.46
mmol/l
0.30
107
1448
339
3057
1.17
1.53
4.8
3.0
162.97
141.01
ug/l
0.51
315
2788
7
27
2.60
1.51
1.7
1.9
559.00
885.93
u/ml
—
7
27
11
51
2.17
1.51
2.0
1.2
—
—
—
0
0
13
65
2.01
1.49
4.2
1.6
11.28
10.38
%
0.34
13
65
16
280
0.56
1.49
1.6
1.8
3.65
3.47
mmol/l
—
10
206
17
94
1.82
1.48
1.3
1.8
88.21
89.83
%
0.44
17
94
36
246
1.48
1.42
1.3
1.2
—
—
—
0
0
18
103
1.76
1.41
1.6
1.2
203.42
266.72
u/ml
0.45
12
55
408
3753
1.15
1.39
11.4
8.8
4.59
4.36
e9/l
0.89
347
3240
5
17
2.95
1.36
1.4
1.4
25.80
28.41
%
—
5
17
147
1245
1.21
1.34
4.5
3.3
1.82
2.14
e6/l
0.25
78
651
18
108
1.68
1.23
1.4
1.3
—
—
—
0
0
34
239
1.44
1.19
2.1
2.0
19.25
8.78
iu/ml
—
6
61
67
528
1.29
1.17
3.6
4.0
—
—
—
0
0
51
387
1.34
1.16
1.5
1.4
—
—
—
0
0
8
39
2.06
1.15
1.0
1.2
—
—
—
0
0
21
319
0.65
1.15
1.5
1.4
—
—
—
0
0
141
1633
0.84
1.14
1.3
1.4
—
—
—
0
0
7
30
2.34
1.12
2.6
1.9
41.33
39.53
g/l
—
7
30
45
337
1.35
1.12
1.2
1.3
—
—
—
0
0
363
3914
0.88
1.11
4.0
3.3
75.86
53.60
u/l
2.38
338
3618
7
31
2.27
1.10
1.1
1.1
—
—
—
0
0
7
137
0.51
1.10
1.0
2.1
216.43
225.06
pmol/l
—
7
130
23
153
1.52
1.07
1.1
1.1
—
—
—
0
0
6
122
0.49
1.05
1.0
1.1
1.00
0.89
g/l
—
6
122
5
22
2.28
1.03
1.4
2.1
—
—
—
0
0
209
2327
0.87
1.03
2.0
1.9
1.31
1.30
mmol/l
0.10
175
1905
9
48
1.88
1.00
1.7
1.2
—
—
—
0
0
7
35
2.01
1.00
1.9
1.5
—
—
—
0
0
0
30
0.00
0.97
0.0
1.3
—
136.73
—
0
30
9
51
1.77
0.94
1.0
1.3
—
—
—
0
0
15
93
1.62
0.94
1.0
1.1
—
—
—
0
0
396
3714
1.11
0.90
7.9
6.2
14.36
12.43
umol/l
1.86
377
3524
150
1323
1.16
0.90
1.4
1.3
1.10
1.30
u/ml
0.18
35
346
5
102
0.49
0.89
1.0
1.1
—
0.68
—
0
16
76
633
1.22
0.87
2.4
2.2
0.00
0.03
estimate
0.50
20
118
83
698
1.21
0.87
2.4
2.4
167.69
140.84
ug/g
0.27
69
550
42
326
1.30
0.86
2.1
2.0
—
—
—
0
0
225
2048
1.13
0.85
4.9
3.4
—
0.00
estimate
—
0
14
6
115
0.52
0.83
1.0
1.1
1.50
1.55
g/l
—
6
115
17
113
1.51
0.82
1.2
1.2
—
—
—
0
0
208
2282
0.89
0.82
2.0
1.8
19.43
20.12
nmol/l
0.25
181
1912
362
3394
1.11
0.81
11.3
6.1
1.20
1.21
mmol/l
2.21
332
3093
18
122
1.48
0.80
1.8
1.6
—
—
—
0
0
0
25
0.00
0.79
0.0
5.3
—
37.99
—
0
17
8
48
1.67
0.79
2.9
1.7
—
—
—
0
0
12
74
1.63
0.78
1.2
1.1
—
—
—
0
0
23
314
0.73
0.77
2.3
3.3
43.12
12991.05
u/ml
0.85
17
268
12
75
1.61
0.75
1.2
1.1
—
—
—
0
0
69
816
0.83
0.74
3.8
4.1
6.70
27.12
ug/l
1.29
59
701
42
334
1.27
0.74
2.8
3.1
—
—
—
0
0
56
461
1.23
0.74
1.2
1.2
—
—
—
0
0
8
133
0.60
0.74
1.3
1.2
3.63
3.82
mmol/l
—
8
126
16
108
1.49
0.74
3.8
2.1
31.94
32.48
pg
0.19
16
108
11
171
0.64
0.72
1.2
2.0
39.64
41.36
nmol/l
0.12
11
162
25
185
1.36
0.72
4.9
4.0
—
—
—
0
0
82
705
1.18
0.70
1.9
1.6
—
—
—
0
0
15
101
1.49
0.70
3.0
1.4
—
—
—
0
0
177
1609
1.12
0.70
4.3
3.2
526.10
540.57
mosm/kgh2o
0.45
156
1405
9
58
1.56
0.70
2.7
1.1
—
—
—
0
0
24
178
1.36
0.69
1.2
1.2
—
880.00
—
0
5
13
85
1.54
0.69
1.7
3.9
—
—
—
0
0
45
550
0.81
0.68
2.2
3.2
6.03
6.11
ph
0.28
32
396
81
700
1.17
0.66
2.7
2.2
0.19
0.20
g/l
0.50
72
635
5
28
1.79
0.66
2.4
4.1
74.80
179.96
nmol/l
—
5
28
280
2985
0.91
0.64
3.1
2.4
81.21
78.46
nmol/l
0.90
254
2616
175
1600
1.12
0.63
1.9
1.8
1223.78
1173.05
nmol/l
0.29
135
1185
443
4236
1.09
0.62
8.4
4.9
6.86
6.85
mmol/l
0.03
421
4039
234
2179
1.10
0.60
5.1
3.5
0.72
0.50
e6/l
0.69
188
1660
315
3326
0.92
0.57
2.5
2.3
96.46
93.71
pmol/l
0.49
175
1763
20
150
1.34
0.56
1.6
1.2
—
—
—
0
0
63
728
0.86
0.55
1.3
1.3
—
—
—
0
0
149
1624
0.90
0.54
5.6
4.7
1.02
1.02
kg/l
1.09
109
1092
104
933
1.13
0.53
1.4
1.3
14.09
10.83
u/ml
0.18
28
329
177
1910
0.91
0.53
5.0
4.0
0.04
0.07
estimate
0.23
56
612
21
161
1.31
0.52
1.3
1.4
61.07
61.94
mmol/l
0.03
15
132
9
64
1.41
0.51
4.2
1.5
—
—
—
0
0
230
2158
1.09
0.50
3.6
3.2
35.58
35.22
u/l
0.03
217
2032
257
2719
0.92
0.49
5.6
4.5
0.02
0.05
estimate
1.15
65
657
64
559
1.16
0.49
1.6
1.5
—
—
—
0
0
235
2212
1.08
0.48
3.0
2.5
59.83
98.08
u/l
0.53
219
2050
10
143
0.70
0.48
6.3
3.4
59.89
2040.97
u/ml
—
10
135
7
47
1.49
0.47
2.1
1.8
372.86
96.42
ng/l
—
7
47
243
2293
1.08
0.47
4.3
4.2
17.24
9.53
mg/mmol
1.20
169
1493
48
557
0.85
0.46
1.8
1.6
—
—
—
0
0
17
129
1.32
0.46
2.8
1.4
—
—
—
0
0
150
1617
0.91
0.45
1.9
1.8
72656698.12
8979720.07
pmol/l
0.42
128
1303
15
112
1.34
0.45
2.3
3.2
4.08
4.54
e9/l
0.53
15
112
7
51
1.38
0.44
1.0
1.2
123.14
91.31
pmol/l
—
7
51
9
128
0.70
0.43
1.3
1.4
—
—
—
0
0
451
4659
0.94
0.43
6.9
5.5
1282.57
2914.42
e6/l
—
7
86
193
1811
1.08
0.43
3.8
2.8
6.34
5.01
e6/l
0.71
174
1648
29
349
0.83
0.43
1.9
1.6
—
—
—
0
0
17
131
1.30
0.42
6.1
3.1
17.54
10.47
pmol/l
0.63
17
131
347
3612
0.94
0.42
5.6
4.4
0.00
0.40
estimate
0.52
70
767
8
57
1.41
0.42
2.3
2.1
—
—
—
0
0
5
33
1.52
0.41
1.4
1.3
99.84
165.79
pmol/l
—
5
33
15
114
1.32
0.41
2.1
2.9
—
—
—
0
0
111
1019
1.10
0.40
1.4
1.3
43.71
32.53
iu/ml
0.44
34
326
74
665
1.12
0.40
4.7
4.3
7.38
7.35
ph
0.77
50
467
345
3586
0.94
0.40
5.6
4.4
0.00
4.30
estimate
0.80
74
815
24
196
1.23
0.39
1.6
1.4
240.98
287.12
ug/g
0.55
17
109
0
19
0.00
0.39
0.0
5.2
—
8.34
—
0
19
12
158
0.76
0.37
1.2
1.8
—
—
—
0
0
9
69
1.31
0.37
1.2
1.3
—
—
—
0
0
9
69
1.31
0.37
1.2
1.2
—
—
—
0
0
18
143
1.26
0.37
2.4
3.2
61.50
60.14
%
0.19
18
143
17
134
1.27
0.37
2.9
1.4
—
—
—
0
0
241
2298
1.07
0.36
2.8
2.1
162.04
253.03
u/l
1.56
230
2158
17
135
1.26
0.35
2.9
1.4
—
—
—
0
0
17
135
1.26
0.35
2.9
1.4
—
—
—
0
0
10
134
0.74
0.35
1.1
1.6
—
—
—
0
0
10
73
1.37
0.34
1.2
1.3
—
—
—
0
0
50
561
0.89
0.33
6.1
4.3
—
—
—
0
0
63
569
1.11
0.33
5.5
4.1
0.54
0.66
%
0.35
26
182
499
5108
0.95
0.32
10.8
8.0
86.85
82.14
u/l
0.91
471
4790
343
3543
0.95
0.31
5.7
4.4
0.00
0.00
estimate
-0.00
75
786
26
221
1.18
0.31
5.3
5.7
1.26
1.38
mmol/l
0.42
21
194
239
2292
1.06
0.30
3.9
3.4
7.00
7.29
mmol/l
0.50
196
1895
207
1977
1.06
0.30
8.0
6.2
—
—
—
0
0
388
3770
1.05
0.30
11.7
6.8
1.20
1.21
mmol/l
0.83
336
3212
24
204
1.18
0.29
1.6
1.6
50.86
14.76
u/ml
—
8
32
10
76
1.32
0.28
1.1
1.1
0.55
2.02
u/ml
—
5
39
8
62
1.29
0.28
1.8
1.1
—
—
—
0
0
19
226
0.84
0.27
1.2
1.4
0.20
0.32
mg/l
—
9
95
27
311
0.86
0.27
1.2
1.3
53.07
132.04
u/ml
1.17
12
116
8
65
1.23
0.27
1.3
1.1
1.06
1.81
nmol/l
—
8
55
12
150
0.80
0.27
1.3
1.3
370.92
482.41
mg/l
1.36
12
145
297
2875
1.05
0.26
4.8
3.9
6.41
6.26
ph
1.44
160
1597
10
77
1.30
0.26
1.7
2.2
3.80
1.54
u/field
—
5
37
63
580
1.09
0.25
6.1
4.1
0.12
0.13
%
0.07
26
175
18
212
0.85
0.24
24.5
11.6
—
—
—
0
0
12
97
1.24
0.23
1.7
1.1
—
—
—
0
0
7
91
0.77
0.22
1.1
1.1
—
14.00
—
0
25
35
314
1.12
0.22
1.3
1.2
—
—
—
0
0
5
40
1.25
0.22
2.0
1.5
34.08
30.35
u/l
—
5
33
345
3364
1.04
0.22
6.5
4.9
34.10
34.57
g/l
0.81
314
3122
261
2531
1.04
0.22
5.2
3.6
165.79
110.77
e6/l
0.21
208
1988
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
151.50
—
0
6
0
12
0.00
0.21
0.0
2.1
—
2.37
—
0
12
5
43
1.16
0.21
1.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
40.85
—
0
13
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
6
50
1.20
0.19
1.3
1.2
—
—
—
0
0
249
2561
0.96
0.19
2.8
3.3
2.34
2.35
mmol/l
0.36
205
2280
16
137
1.17
0.19
3.1
1.4
—
—
—
0
0
65
609
1.07
0.18
6.0
4.1
0.93
0.90
%
0.04
28
205
42
387
1.09
0.18
1.4
1.2
—
—
—
0
0
42
388
1.09
0.17
1.3
1.4
—
—
—
0
0
7
63
1.11
0.17
3.1
1.3
—
—
—
0
0
8
69
1.16
0.16
2.8
2.8
—
—
—
0
0
20
225
0.89
0.16
1.0
1.1
—
—
—
0
0
20
177
1.13
0.16
3.1
2.4
113.53
86.67
ug/min
0.19
15
107
8
70
1.14
0.16
1.3
1.2
—
—
—
0
0
8
72
1.11
0.16
1.6
1.2
—
98.12
—
0
6
6
76
0.79
0.15
1.7
2.3
—
—
—
0
0
6
77
0.78
0.15
1.2
1.2
—
—
—
0
0
224
2298
0.97
0.15
7.2
3.9
7.40
7.40
ph
1.04
170
1646
17
190
0.89
0.13
2.6
2.3
123.64
126.26
g/l
0.25
11
149
84
875
0.96
0.12
1.3
1.2
—
—
—
0
0
260
2556
1.02
0.10
4.1
3.7
—
—
—
0
0
210
2059
1.03
0.10
5.6
4.5
0.00
0.01
estimate
0.96
60
694
5
45
1.11
0.10
1.0
1.2
—
—
—
0
0
6
55
1.09
0.09
1.0
1.4
—
—
—
0
0
5
60
0.83
0.08
1.2
1.1
—
—
—
0
0
42
401
1.05
0.08
2.7
2.5
—
—
—
0
0
7
80
0.87
0.07
1.1
1.2
—
—
—
0
0
9
84
1.07
0.07
1.3
1.3
—
0.82
—
0
5
9
85
1.06
0.07
1.0
1.3
—
—
—
0
0
9
85
1.06
0.07
1.0
1.3
—
—
—
0
0
9
85
1.06
0.07
1.0
1.3
—
—
—
0
0
9
85
1.06
0.07
1.0
1.3
—
—
—
0
0
225
2224
1.02
0.06
4.0
3.4
69.55
54.73
mg/l
0.45
165
1498
311
3135
0.99
0.05
4.0
2.9
—
—
estimate
—
0
0
83
814
1.02
0.04
2.0
1.8
—
—
—
0
0
150
1481
1.02
0.04
2.1
1.7
1.20
1.51
mg/l
1.12
114
1177
178
1800
0.99
0.04
4.2
3.5
0.50
0.08
—
6
74
21
200
1.05
0.03
1.2
1.2
—
—
—
0
0
24
230
1.04
0.03
8.0
5.1
—
—
—
0
0
11
102
1.08
0.03
1.3
2.5
—
—
—
0
0
57
581
0.98
0.03
6.9
4.4
0.00
0.13
%
1.46
20
161
292
2908
1.01
0.02
17.9
11.9
0.00
0.00
e9/l
0.28
230
2359
11
117
0.94
0.01
2.5
1.3
—
—
—
0
0
66
653
1.01
0.01
1.7
1.9
362.95
395.94
nmol/l
0.79
59
598
17
164
1.04
0.00
1.1
1.1
—
—
—
0
0
134
1345
1.00
0.00
6.9
4.8
—
—
—
0
0
78
785
0.99
0.00
1.6
1.4
—
—
—
0
0
278
2779
1.00
0.00
6.3
4.2
182.07
160.43
e6/l
0.10
212
2052
6
60
1.00
0.00
1.2
2.8
9.85
8.44
mmol/l
—
6
60
6
60
1.00
0.00
1.0
1.1
—
—
—
0
0
5
57
0.88
0.00
3.4
2.3
562.20
557.69
ml
—
5
35
8
85
0.94
-0.00
5.1
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
6
67
0.89
-0.00
1.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
13.4
—
0.22
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
0.05
—
0
7
6
63
0.95
-0.00
1.3
1.3
19.82
26.99
ng/l
—
6
63
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
67.11
—
0
9
5
54
0.93
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
9
98
0.92
-0.00
1.0
1.1
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint I9_RHEUVALV and mortality.

Females

Parameter HR [95% CI] p-value
I9_RHEUVALV 2.207 [1.98, 2.46] < 0.001
Birth year 0.994 [0.99, 1.0] 0.169

During the follow-up period (1.1.1998 — 31.12.2019), 1537 out of 2635 females with I9_RHEUVALV died.

Males

Parameter HR [95% CI] p-value
I9_RHEUVALV 2.004 [1.75, 2.29] < 0.001
Birth year 0.991 [0.98, 1.0] 0.047

During the follow-up period (1.1.1998 — 31.12.2019), 1155 out of 2107 males with I9_RHEUVALV died.

Mortality risk

Mortality risk for people of age

years, who have I9_RHEUVALV.

N-year risk Females Males
1 0.171% 0.411%
5 1.219% 2.429%
10 2.95% 6.713%
15 5.653% 11.989%
20 10.282% 19.825%

Relationships between endpoints

↥

Index endpoint: I9_RHEUVALV – Rheumatic valve diseases

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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